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2. Post-mortem tetramorphism: Four morphological changes within the same corpse

Author

Zanovello, Claudia, Pallocci, Margherita, Passalacqua, Pierluigi, Mazzuca, Daniela, De Luca, Lucilla, Caparrelli, Valentina, Milano, Filippo, and Treglia, Michele

Abstract

Transformative processes generally occur singly and jointly involving the whole body. Rarely, they appear simultaneously as distinct transformative phenomena. The case study relates to a corpse found inside a storage tank in a rather unusual position, during the winter months. On external examination carried out at the crime scene, both legs and feet were out of the well bending over the storage tank and showing skeletonisation and tissue defects due to biting inflicted by the environmental macrofauna. The thighs were also skeletonised, inside the well but not immersed in the water, as was the torso which, however, was entirely corified. The colliquated shoulders, head and upper limbs were fully immersed into the water as well as the macerated hands. The corpse was exposed simultaneously to three different environmental conditions: the external setting with changes in temperature, rainfall and the action of the macro fauna, the unventilated and humid setting inside the tank, and lastly the stored water. The corpse, lying in a specific position and being exposed to different atmospheric conditions, underwent four post-mortem changes at the same time, making it challenging to estimate the time of death, based only on the available data and macroscopic findings.

Published
2024
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3. A MISSED OPPORTUNITY IN R V LANGAN: APPELLATE REVIEW OF PRIOR CONSISTENT STATEMENTS POST-KHAN.

Author

Mazzuca, Samuel

Abstract

Copyright of Canadian Bar Review is the property of Canadian Bar Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

6. Postprandial glucose metabolism in children and adolescents with type 1 diabetes mellitus: potential targets for improvement

Author

Maguolo, Alice, Mazzuca, Giorgia, Smart, Carmel E., and Maffeis, Claudio

Abstract

The main goal of therapeutic management of type 1 Diabetes Mellitus (T1DM) is to maintain optimal glycemic control to prevent acute and long-term diabetes complications and to enable a good quality of life. Postprandial glycemia makes a substantial contribution to overall glycemic control and variability in diabetes and, despite technological advancements in insulin treatments, optimal postprandial glycemia is difficult to achieve. Several factors influence postprandial blood glucose levels in children and adolescents with T1DM, including nutritional habits and adjustment of insulin doses according to meal composition. Additionally, hormone secretion, enteroendocrine axis dysfunction, altered gastrointestinal digestion and absorption, and physical activity play important roles. Meal-time routines, intake of appropriate ratios of macronutrients, and correct adjustment of the insulin dose for the meal composition have positive impacts on postprandial glycemic variability and long-term cardiometabolic health of the individual with T1DM. Further knowledge in the field is necessary for management of all these factors to be part of routine pediatric diabetes education and clinical practice. Thus, the aim of this report is to review the main factors that influence postprandial blood glucose levels and metabolism, focusing on macronutrients and other nutritional and lifestyle factors, to suggest potential targets for improving postprandial glycemia in the management of children and adolescents with T1DM.

Published
2024
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8. Making it abstract, making it contestable: politicization at the intersection of political and cognitive science

Author

Mazzuca, Claudia and Santarelli, Matteo

Abstract

The notion of politicization has been often assimilated to that of partisanship, especially in political and social sciences. However, these accounts underestimate more fine-grained, and yet pivotal, aspects at stake in processes of politicization. In addition, they overlook cognitive mechanisms underlying politicizing practices. Here, we propose an integrated approach to politicization relying on recent insights from both social and political sciences, as well as cognitive science. We outline two key facets of politicization, that we call partial indeterminationand contestability, and we show how these can be accounted for by appealing to recent literature in cognitive science concerned with abstract conceptual knowledge. We suggest that politicizing a concept often implies making its more abstract components more salient, hence legitimating its contestable character. Finally, we provide preliminary suggestions to test our proposal, using the concept of genderas case study.

Published
2023
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10. CT and Functional Outcomes of Primarily Ligamentous and Combined Ligamentous-Bony Lisfranc Injuries: A Retrospective Review.

Author

Huyke-Hernández, Fernando A., Lesmeister, Nicholas, Yonke, Bret, and Mazzuca, James

Abstract

Lisfranc injuries have been rising in incidence and can cause significant and lasting morbidity. There is no consensus on the optimal surgical treatment for these injuries, be they primarily ligamentous or combined (bony and ligamentous). No study has ever followed Lisfranc injury patients postoperatively using advanced imaging. The purpose of this study was to compare the functional and radiographic outcomes of primarily ligamentous and combined osseous and ligamentous Lisfranc injuries treated operatively with reduction and fixation. We performed a retrospective review of all Lisfranc injuries treated operatively in a single institution over a 6-year period. Injuries were classified as primarily ligamentous or combined by independent evaluation of available computed tomography (CT) or magnetic resonance imaging. Outcomes were measured using the Short Musculoskeletal Function Assessment (SMFA). CT of 29 patients was performed at last follow-up to evaluate reduction and degenerative changes. Of the 56 patients identified, 38 were available for follow-up. The average follow-up was 3.8 years. There were 26 combined injuries and 12 primarily ligamentous injuries. Outcomes were excellent in all patients and there was no statistical difference in SMFA scores in any category between the groups. On follow-up CT, all injuries were anatomically reduced, and 26 of 29 patients had degenerative changes. Our results support that reduction and stable fixation of Lisfranc injuries may be suitable treatment regardless of classification as combined or primarily ligamentous. Future larger-scale prospective studies should be pursued to supplement existing data. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Fructooligosacáridos, extracto de Cynara scolymus y cloruro de colina como suplementos dietario en la crianza de pollos parrilleros (Gallus gallus).

Author

Ocaña, J. G., Mazzuca Pizetti, A. J., Sarmiento, R. O., and Sánchez Negrette, O.

Subjects
BROILER chickens, ARTICHOKES, BIRD breeding, ONE-way analysis of variance, CHOLINE chloride, BODY weight, EUTECTICS
Abstract

Copyright of Revista Veterinaria is the property of Universidad Nacional del Nordeste and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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12. Codon-specific KRASmutations predict survival benefit of trifluridine/tipiracil in metastatic colorectal cancer

Author

van de Haar, Joris, Ma, Xuhui, Ooft, Salo N., van der Helm, Pim W., Hoes, Louisa R., Mainardi, Sara, Pinato, David J., Sun, Kristi, Salvatore, Lisa, Tortora, Giampaolo, Zurlo, Ina Valeria, Leo, Silvana, Giampieri, Riccardo, Berardi, Rossana, Gelsomino, Fabio, Merz, Valeria, Mazzuca, Federica, Antonuzzo, Lorenzo, Rosati, Gerardo, Stavraka, Chara, Ross, Paul, Rodriquenz, Maria Grazia, Pavarana, Michele, Messina, Carlo, Iveson, Timothy, Zoratto, Federica, Thomas, Anne, Fenocchio, Elisabetta, Ratti, Margherita, Depetris, Ilaria, Cergnul, Massimiliano, Morelli, Cristina, Libertini, Michela, Parisi, Alessandro, De Tursi, Michele, Zanaletti, Nicoletta, Garrone, Ornella, Graham, Janet, Longarini, Raffaella, Gobba, Stefania Maria, Petrillo, Angelica, Tamburini, Emiliano, La Verde, Nicla, Petrelli, Fausto, Ricci, Vincenzo, Wessels, Lodewyk F. A., Ghidini, Michele, Cortellini, Alessio, Voest, Emile E., and Valeri, Nicola

Abstract

Genomics has greatly improved how patients with cancer are being treated; however, clinical-grade genomic biomarkers for chemotherapies are currently lacking. Using whole-genome analysis of 37 patients with metastatic colorectal cancer (mCRC) treated with the chemotherapy trifluridine/tipiracil (FTD/TPI), we identified KRAScodon G12 (KRASG12) mutations as a potential biomarker of resistance. Next, we collected real-world data of 960 patients with mCRC receiving FTD/TPI and validated that KRASG12mutations were significantly associated with poor survival, also in analyses restricted to the RAS/RAFmutant subgroup. We next analyzed the data of the global, double-blind, placebo-controlled, phase 3 RECOURSE trial (n= 800 patients) and found that KRASG12mutations (n= 279) were predictive biomarkers for reduced overall survival (OS) benefit of FTD/TPI versus placebo (unadjusted interaction P= 0.0031, adjusted interaction P= 0.015). For patients with KRASG12mutations in the RECOURSE trial, OS was not prolonged with FTD/TPI versus placebo (n= 279; hazard ratio (HR) = 0.97; 95% confidence interval (CI) = 0.73–1.20; P= 0.85). In contrast, patients with KRASG13mutant tumors showed significantly improved OS with FTD/TPI versus placebo (n= 60; HR = 0.29; 95% CI = 0.15–0.55; P< 0.001). In isogenic cell lines and patient-derived organoids, KRASG12mutations were associated with increased resistance to FTD-based genotoxicity. In conclusion, these data show that KRASG12mutations are biomarkers for reduced OS benefit of FTD/TPI treatment, with potential implications for approximately 28% of patients with mCRC under consideration for treatment with FTD/TPI. Furthermore, our data suggest that genomics-based precision medicine may be possible for a subset of chemotherapies.

Published
2023
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13. Mutual interaction of pyrolysis operating conditions and surface morphology for the electrochemical performance of biochar-modified screen-printed electrodes

Author

Cancelliere, Rocco, Mele, Pietro, Bartolucci, Lorenzo, Cordiner, Stefano, da Silva Freitas, Williane, Mazzuca, Claudia, Mecheri, Barbara, Micheli, Laura, Mulone, Vincenzo, Paialunga, Elisa, and Severini, Leonardo

Abstract

The transition towards a low-emission economy requires advanced carbon-based materials for multiple applications.

Published
2025
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14. What does “Internet” mean to us as we age? A multi-task investigation on the conceptualization of the technological domain across generations

Author

Falcinelli, Ilenia, Fini, Chiara, Mazzuca, Claudia, Alessandri, Guido, Alivernini, Fabio, Baiocco, Roberto, Chirico, Andrea, Filosa, Lorenzo, Palombi, Tommaso, Pistella, Jessica, Tavolucci, Simone, Lucidi, Fabio, and Borghi, Anna M.

Abstract

Technological progress is increasing rapidly, and keeping up is particularly challenging for older adults. Thus, adapting technological innovations to human needs has become urgent. The first step toward this aim is to understand how people conceptualize technology.Here, we asked 54 younger and 54 older adults to perform a Go/No-Go, a rating, and a feature generation task to investigate the processing and representation of Technological concepts (e.g., “Internet”) compared to Abstract (e.g., “logic”) and Concrete concepts (e.g., “bottle”). Younger adults showed an elaboration advantage for Technological upon Abstract and Concrete concepts. Technological concepts exhibited a hybridcharacter, but in older adults, they had a more abstract characterization. Finally, the semantic knowledge associated with Technology was differently organized in content across generations and less structurally robust in older adults. Overall, our results highlight how concepts flexibly change across life and can help societal policies to increase awareness in technology-use across generations.

Published
2024
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15. Forensic applications of hyperspectral imaging technique: a narrative review

Author

Pallocci, Margherita, Treglia, Michele, Passalacqua, Pierluigi, Luca, Lucilla De, Zanovello, Claudia, Mazzuca, Daniela, Guarna, Francesca, Gratteri, Santo, and Marsella, Luigi T

Abstract

Hyperspectral imaging (HSI) collects and processes information from the entire electromagnetic spectrum to obtain the spectrum of each pixel in the image of a scene, with the aim of finding objects and identifying materials. It is a non-contact, non-destructive technology that can be used without modifying or altering the analysed target. Forensic analysis and crime scene investigations are two of the most investigated fields of application, being able to detect and analyse many types of evidence.In this paper we analysed the most commonly reported forensic science applications.The literature indicates that the fields in which HSI appears most promising are the analysis of blood traces, document forgery, gunshot residues and the identification of fingerprints.

Published
2022
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17. Resectable gastric cancer: should we apply a tailored surgical strategy according to microsatellite status?

Author

Muttillo, Edoardo Maria, Di Cicco, Leonardo, La Franca, Alice, Lucarini, Alessio, Arrivi, Giulia, Li Causi, Francesco Saverio, Castagnola, Giorgio, Scarinci, Andrea, Pilozzi, Emanuela, Mazzuca, Federica, Balducci, Genoveffa, Meniconi, Roberto Luca, Ettorre, Giuseppe Maria, and Mercantini, Paolo

Abstract

High microsatellite instability (MSI) represents a small subgroup of gastric cancer (GC) with favorable prognostic and predictive significance. This study aimed to investigate locoregional lymph node (LN) involvement, overall survival (OS), disease-free survival (DFS), and the interplay between molecular subtypes and histologic profiles regarding survival outcomes in MSI GC vs microsatellite stability (MSS) GC.

Published
2025
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19. COVID-19 ARDS Is Characterized by Increased Dead Space Ventilation ComparedWith Non-COVID ARDS.

Author

Bertelli, Michele, Fusina, Federica, Prezioso, Chiara, Cavallo, Erika, Nencini, Niccolò, Crisci, Serena, Tansini, Francesca, Mari, Letizia Mazzuca, Hoxha, Laureta, Lombardi, Fabiana, and Natalini, Giuseppe

Subjects
INTENSIVE care units, STATISTICS, STATISTICAL significance, COVID-19, CONFIDENCE intervals, AIRWAY (Anatomy), MULTIVARIATE analysis, MULTIPLE organ failure, CONTINUING education units, RETROSPECTIVE studies, MANN Whitney U Test, FISHER exact test, REGRESSION analysis, ARTIFICIAL respiration, ADULT respiratory distress syndrome, MATHEMATICAL variables, DESCRIPTIVE statistics, POLYMERASE chain reaction, ELECTRONIC health records, LOGISTIC regression analysis, DATA analysis software, ODDS ratio, LONGITUDINAL method
Abstract

Background: ARDS in patients with coronavirus disease 2019 (COVID-19) is characterized by microcirculatory alterations in the pulmonary vascular bed, which could increase dead-space ventilation more than in non-COVID-19 ARDS. We aimed to establish if dead-space ventilation is different in patients with COVID-19 ARDS when compared with patients with non-COVID-19 ARDS. Methods: A total of 187 subjects with COVID-19 ARDS and 178 subjects with non-COVID-19 ARDS who were undergoing invasive mechanical ventilation were included in the study. The association between the ARDS types and dead-space ventilation, compliance of the respiratory system, subjects' characteristics, organ failures, and mechanical ventilation was evaluated by using data collected in the first 24 h of mechanical ventilation. Results: Corrected minute ventilation (VE), a dead-space ventilation surrogate, was higher in the subjects with COVID-19 ARDS versus in those with non-COVID-19 ARDS (median [interquartile range] 12.6 [10.2-15.8] L/min vs 9.4 [7.5-11.6] L/min; P < .001). Increased corrected VE was independently associated with COVID-19 ARDS (odds ratio 1.24, 95% CI 1.07-1.47; P = .007). The best compliance of the respiratory system, obtained after testing different PEEPs, was similar between the subjects with COVID-19 ARDS and the subjects with non-COVID-19 ARDS (mean ± SD 38 ± 11 mL/cm H2O vs 37 ± 11 mL/cm H2O, respectively; P = .61). The subjects with COVID-19 ARDS received higher median (interquartile range) PEEP (12 [10-14] cm H2O vs 8 [5-9] cm H2O; P < .001) and lower median (interquartile range) tidal volume (5.8 [5.5-6.3] mL/kg vs 6.6 [6.1-7.3] mL/kg; P < .001) than the subjects with non-COVID-19 ARDS, being these differences maintained at multivariable analysis. In the multivariable analysis, the subjects with COVID-19 ARDS showed a lower risk of anamnestic arterial hypertension (odds ratio 0.18, 95% CI 0.07-0.45; P < .001) and lower neurologic sequential organ failure assessment score (odds ratio 0.16, 95% CI 0.09-0.27; P < .001) than the subjects with non-COVID-19 ARDS. Conclusions: Indirect measurements of dead space were higher in subjects with COVID-19 ARDS compared with subjects with non-COVID-19 ARDS. The best compliance of the respiratory system was similar in both ARDS forms provided that different PEEPs were applied. A wide range of compliance is present in every ARDS type; therefore, the setting of mechanical ventilation should be individualized patient by patient and not based on the etiology of ARDS. [ABSTRACT FROM AUTHOR]

Published
2021
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22. Walking for subjects with type 2 diabetes: A systematic review and joint AMD/SID/SISMES evidence-based practical guideline.

Author

Moghetti, P., Balducci, S., Guidetti, L., Mazzuca, P., Rossi, E., Schena, F., Italian Society of Diabetology (SID),, Italian Association of Medical Diabetologists (AMD),, and Italian Society of Motor and Sports Sciences (SISMES)

Abstract

Aims: Regular exercise is considered a cornerstone in the management of type 2 diabetes mellitus (T2DM). It improves glucose control and cardiovascular risk factors, contributes to weight loss, and also improves general well-being, likely playing a role in the prevention of chronic complications of diabetes. However, compliance to exercise recommendations is generally inadequate in subjects with T2DM. Walking is the most ancestral form of physical activity in humans, easily applicable in daily life. It may represent, in many patients, a first simple step towards lifestyle changes. Nevertheless, while most diabetic patients do not engage in any weekly walking, exercise guidelines do not generally detail how to improve its use. The aims of this document are to conduct a systematic review of available literature on walking as a therapeutic tool for people with T2DM, and to provide practical, evidence-based clinical recommendations regarding its utilization in these subjects.Data Synthesis: Analysis of available RCTs proved that regular walking training, especially when supervised, improves glucose control in subjects with T2DM, with favorable effects also on cardiorespiratory fitness, body weight and blood pressure. Moreover, some recent studies have shown that even short bouts of walking, used for breaking prolonged sitting, can ameliorate glucose profiles in diabetic patients with sedentary behavior.Conclusions: There is sufficient evidence to recognize that walking is a useful therapeutic tool for people with T2DM. This document discusses theoretical and practical issues for improving its use. This article is co-published in the journals Sport Sciences for Health and Nutrition, Metabolism and Cardiovascular Diseases. [ABSTRACT FROM AUTHOR]

Published
2020
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23. Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Author

Wright, Naomi Jane, Leather, Andrew J.M., Ade-Ajayi, Niyi, Sevdalis, Nick, Davies, Justine, Poenaru, Dan, Ameh, Emmanuel, Ademuyiwa, Adesoji, Lakhoo, Kokila, Smith, Emily Rose, Douiri, Abdel, Elstad, Maria, Sim, Marcus, Riboni, Cristiana, Martinez-Leo, Bruno, Akhbari, Melika, Tabiri, Stephen, Mitul, Ashrarur, Aziz, Dayang Anita Abdul, Fachin, Camila, Niyukuri, Alliance, Arshad, Muhammad, Ibrahim, Fowzia, Moitt, Natalie, Doheim, Mohamed Fahmy, Thompson, Hannah, Ubhi, Harmony, Williams, Isabelle, Hashim, Sophia, Philipo, Godfrey Sama, Herrera, Laura, Yunus, Aayenah, Vervoort, Dominique, Parker, Samuel, Benaskeur, Yousra-Imane, Alser, Osaid H., Adofo-Ansong, Nana, Alhamid, Ahmad, Salem, Hosni khairy, Saleh, Mahmoud, Elrais, Safa Abdal, Abukhalaf, Sadi, Shinondo, Patricia, Nour, Ibrahim, Aydin, Emrah, Vaitkiene, Agota, Naranjo, Kelly, Dube, Andile Maqhawe, Ngwenya, Sodumisa, Yacoub, Mina A., Kwasau, Henang, Hyman, Gabriella, Elghazaly, Shrouk Mahmoud, Al-Slaibi, Ibrahim, Hisham, Intisar, Franco, Helena, Arbab, Hana, Samad, Lubna, Soomro, Aqil, Chaudhry, Muhammad Amjad, Karim, Safina, Khattak, Muhammad Adnan Khan, Nah, Shireen Anne, Dimatatac, Doris Mae, Choo, Candy SC, Maistry, Niveshni, Mitul, Ashrarur Rahman, Hasan, Samiul, Karim, Sabbir, Yousuf, Hina, Qureshi, Taimur, Nour, Ibrahim Rabi, Al-Taher, Raed Nael, Sarhan, Osama Abdul Kareem, Garcia-Aparicio, Luis, Prat, Jordi, Blazquez-Gomez, Eva, Tarrado, Xavier, Iriondo, Martí, Bragagnini, Paolo, Rite, Segundo, Hagander, Lars, Svensson, Emma, Owusu, Sheila, Abdul-Mumin, Alhassan, Bagbio, Dominic, Ismavel, Vijay Anand, Miriam, Ann, T, Shajin, Anaya Dominguez, Marlene, Ivanov, Monica, Serban, Andreea Madalina, Derbew, Miliard, Elfiky, Mahmoud, Olivos Perez, Maricarmen, Abrunhosa Matias, Marcia, Arnaud, Alexis P, Negida, Ahmed, King, Sebastian, Fazli, Mohamad Rafi, Hamidi, Nadia, Touabti, Souhem, Chipalavela, Rossana Francisco, Lobos, Pablo, Jones, Brendan, Ljuhar, Damir, Singer, Georg, Hasan, Samiul, Cordonnier, Annelien, Jáuregui, Lorena, Zvizdic, Zlatan, Wong, Janice, St-Louis, Etienne, Shu, Qiang, Lui, Yang, Correa, Catalina, Pos, Lucie, Alcántara, Elvyn, Féliz, Erick, Zea-Salazar, Luis Enrique, Ali, Liza, Peycelon, Matthieu, Anatole, Nzanzu Kipata, Jallow, Cherno S., Lindert, Judith, Ghosh, Dhruv, Adhiwidjaja, Cathline Freya, Tabari, Ahmad Khaleghnejad, Lotfollahzadeh, Saran, Mussein, Haidar Mohammad, Vatta, Fabrizio, Pasqua, Noemi, Kihiko, David, Gohil, Hetal, Nour, Ibrahim R., Elhadi, Muhammed, Almada, Suad Ahmed, Verkauskas, Gilvydas, Risteski, Toni, Peñarrieta Daher, Alejandro, Outani, Oumaima, Hamill, James, Lawal, Taiwo, Mulu, Jack, Yapo, Benjamin, Saldaña, Lily, Espineda, Beda, Toczewski, Krystian, Tuyishime, Eugene, Ndayishimiye, Isaac, Raboe, Enaam, Hammond, Philip, Walker, Gregor, Djordjevic, Ivona, Chitnis, Milind, Son, Joonhyuk, Lee, Sanghoon, Hussien, Muaad, Malik, Sawazen, Ismail, Enas Musa, Boonthai, Ampaipan, Dahman, Nesrine Ben Hadj, Hall, Nigel, Castedo Camacho, Fabiola Ruth, Sobrero, Helena, Butler, Marilyn, Makhmud, Aliev, Novotny, Nathan, Hammouri, Ahmad G., Al-Rayyes, Maisara, Bvulani, Bruce, Muraveji, Qais, Murzaie, Muhammad Yousuf, Sherzad, Ajmal, Haidari, Sayed Aman, Monawar, Abdul Baqi, Samadi, Dr. Ahmad Zia, Thiessen, Jesh, Venant, Ntakarutimana, Hospital, Sonia Inamuco, Jérémie, Niyonkuru, Mbonicura, Jean Claude, Vianney, Butoyi Jean Marie, Tadesse, Amezene, Negash, Samuel, Roberts, Charles A., Jabang, John N., Bah, Abdoulie, Camamra, Kajali, Correa, Armandou, Sowe, Babucarr, Gai, A., Jaiteh, Musa, Raymond, Kwizera Jean, Mvukiyehe, Jean Paul, Itangishaka, Innocent, Kayibanda, Emmanuel, Manirambona, Emery, Lule, Joseph, Costas-Chavarri, Ainhoa, Shyaka Gashugi, Ian, Ndata, Albert, Gasana, Georges, Nezerwa, Yves Castar, Simeon, Turatsinze, Muragijimana, Jean De Dieu, Rashid, Sakina, Msuya, David, Elisante, Joseph, Solanki, Meghna, Manjira, Emmanuel, Lodhia, Jay, Jusabani, Mubashir, Tarmohamed, Murad, Koipapi, Sengua, Souhem, Touabti, Sara, Nabti, Sihem, Brahimi, Dania, Bouguermouh, Toufik, Iaiche Achour, Mounira, Baghdadi Nour el islam, Habiba, Alouani, Aragão, Liliana, Gonçalves, Victor, Lino Urquizo, Marcelo Mauricio, Varela, Maria Florencia, Mercado, Pedro, Horacio, Bonavia, Damiani, Andrea, Mac, Carlos, Putruele, Daniel, Liljesthrom, Karen, Bernaus, Marianela, Jauri, Cesar, Cripovich, Alejandrina, Bianchin, Ezequiel, Puig, Maria Gabriela, Andreussi, Lorna, Iracelay, Susana, Marcos, Dolores, Herrera, Carina, Palacios, Nelly, Avile, Romina, Serezo, Belen, Montoya, Debora, Cepeda, Rodrigo, Vaquila, Justo, Veronica, Sofficci, Pardo, Liliana, Valeria, Pelussi, Julio, Lapalma, Martin, Aranda Diego, Lucio, Palazzi, Gabriel, Comba, Marianella, Depetrini, Calderón Arancibia, José Alfredo, Huespe, Enrique, Losa, Gabriela Natalia, Arancibia Gutiérrez, Elsa, Scherl, Humberto, Gonzalez, Daniel Emilio, Baistrocchi, Valentina, Silva, Yanina, Galdeano, Marcelo, Medard, Pablo, Sueiras, Ines, Romero Manteola, Enrique, Defago, Victor Hugo, Mieres, Carlos, Alberto, Carlos, Cornelli, Fabio, Molina, Marcelo, Ravetta, Pablo, Patiño Gonzalez, Celeste Carolina, Dallegre, Maria Belen, Szklarz, Maria Tatiana, Leyba, Marcos Federico, Rivarola, Nahuel Ignacio, Charras, Maria Delia, Morales, Adriana, Caseb, Paloma, Toselli, Luzia, Millán, Carolina, Junes, Maria del Carmen, Di Siervi, Oscar, Gilardi, Jose, Simon, Soledad, Contreras, Carla Sofia, Rojas, Nair, Arnoletto, Lucia Beatriz, Blain, Otilia Eva, Bravo, Mauro Nicolas, Sanchez, Nancy, Herrera Pesara, Luciana Martina, Moreno, Maria Eugenia, Sferco, Carlos Ariel, Huq, Umama, Ferdousi, Tamanna, Al-Mamun, Abdullah, Sultana, Sadia, Mahmud, Refoyez, Mahmud, Khalid, Sayeed, Fatema, Svirsky, Alexander, Sempertegui, Denisse, Negrete, Amalia, Teran, Araceli, Sadagurschi, Mariana, Popovic, Nusret, Karavdic, Kenan, Milisic, Emir, Jonuzi, Asmir, Mesic, Amira, Terzic, Sabina, Dendusic, Nejra, Biber, Elna, Sehic, Anesa, Zvizdic, Nada, Letic, Emina, Saracevic, Adna, Hamidovic, Ajla, Selak, Nejra, Horozic, Dzan, Hukic, Lamija, Muhic, Amila, Vanis, Nedim, Sokolovic, Emir, Sabic, Adnan, Becker, Karin, Novochadlo Klüppel, Elis, dos Santos Dias, André Iván Bradley, Agulham, Miguel Angelo, Bischoff, Cristiano, Sabbatini, Stella, Fernandes de Souza, Rachel, Souza Machado, Ana Beatriz, Werneck Raposo, Juliana, da Silva Augusto, Maria Lucia, Martins, Bianca M.R., de Souza Santos Ferreira, Mariana, Fernandes de Oliveira, Darli, Silva dos Santos, Carla, Ribeiro de Fernández y Alcázar, Fernanda, Alves Dutra da Silva, Érika, Furtado, Mariana, Tamada, Horácio, Silva Ferreira dos Santos, Marília, Lopes de Almeida, Thayná, Oliveira de Andrade, Susy, Gurgel do Amaral, Antonio Cipriano, Sartori Giovanoni, Lais, de Deus Passos Leles, Kamila, Corrêa Costa, Eduardo, Feldens, Leticia, Ferraz Schopf, Luciano, Soares de Fraga, José Carlos, Colombo de Holanda, Felipe, Brolin Santis Isolan, Paola Maria, Loyola Ferreira, Julia, Bruxel, Carla Luisa, Lopes Teixeira Ferdinando, Danielle, Zottis Barcelos, Fabricio, Baseggio, Natalia, Knorr Brenner, Nicole, Trindade Deyl, Rafael, Dure, Carolina, Nunes Kist, Iuri, Bueno Mazzuca, Rafael, Bueno Motter, Sarah, Ramos, Yna, Suzana Trein, Cristine, Rezende Rosa, Bianca, de Assis Silva, Murilo, Menin, Flavio Augusto, Semensato Carloni, Isabela Cristina, Norberto da Silva, Juliana Antinarelli, Gomes, Adriano Luis, Girão Tauffer, Mariana, Bassan Gonçalves, Paulo César, Nogueira Marques, Geraldo Magela, Moriya, Eliane, Labonia, Carla, Carrasco, Ana Lucia, Furtado Meyer, Karine, Farion-Aguiar, Luiz, Amado, Fernando, Antunes, Amanda, Silva, Elisângela, Telles, Leila, Almeida, Giovana, Belmino Gadelha, Aluísio Augusto, de Azevedo Belesa, Flavia, Gonçalves da Cunha, Acimar, Jr, Souza Barros, Beatriz, Zanellato, Josiane Bernartt, Guimarães, Patricia, Silva, Karina Ilheu da, Ribas, Bianca, Reuter, Cristina, Casado, Francis Tanise, Correa Leite, Mila Torii, Testoni, Daniela, Guinsburg, Ruth, de Campos Vieira Abib, Simone, Khodor Cury, Edson, Dornellas do Nascimento, Suely, Almeida Aguiar, Arthur, Melo Gallindo, Rodrigo, Gonçalves Borges, Carolina, Liu, Yang, Duote, Cai, Wang, Jinhu, Gao, Zhigang, Liang, Liang, Luo, Wenjuan, Zhao, Xiaoxia, Chen, Rui, Wang, Peng, Han, Yijiang, Huang, Ting, Donglai, Hu, Xiaodong, Guo, Junjie, Chen, Zhu, Libin, Wu, Guowei, Bao, Xiaozhou, Li, Haijing, Lv, Junying, Li, Zhongrong, Yong, Feng, Gao, Zhou Chong, Bai, Qiang, Tang, Weibing, Xie, Hua, Motee, Jethishka, Zhu, Jianming, Wen, Gang, Ruan, Weiwei, Li, Shungen, Chen, Lulu, Huang, Shungen, Lv, Zhibao, Lu, Jinjing, Huang, Liuming, Yu, Mengnan, Dajia, Wang, Bai, Yu Zuo, Rincon, Luis Carlos, Mancera, Juliana, Alzate Gallego, Edgar, Torres-Canchala, Laura, Silva Beltrán, Nathalia, Osorio Fory, Ghordana, Castaño Avila, Daniela, Forero Ladino, Angelica Maria, Gomez, Juanita, Jaramillo, Martha, Morales, Otto, Sanchez, Beatriz, Tinoco Guzmán, Nestor Julien, Castañeda Espinosa, Sergio, Prieto Vargas, Osbaldo, Pardo, Lina Maria, Toral, Eliana, Cáceres Aucatoma, Freud, Hinostroza, Daniel, Valencia, Santiago, Salinas, Vicente, Landivar Cino, Enrique, Ponce Fajardo, Gabriela Yulissa, Astudillo, Miguel, Garcia, Virginia, Muñoz, Guillermo, Verduga, Leonardo, Verduga, Ivan, Murillo, Ericka, Bucaram, Elena, Guayelema, Marisol, Marmol, Monica, Sanchez, Janina, Vergara, Carolina, Mena, Adriana, Velaña, Junior, Salazar, Karla, Lara, Sandra, Chiriboga, Elena, Silva, Julian, Gad, Dalia, Samy, Doaa, Elsadek, Menan Ahmed, Mohammed, Hanan Mahmoud, Abouheba, Mohamed, Ali, Karim Osamy, Rashwan, Hayssam, Fawzy, Omar Moustafa, Kamel, Tarek mohamed, Nemer, Rawan, Hassan, Mohamed Abada, Falah, Eyad Hassan, Abdelhady, Dina Sobhy, Zain, Mostafa, Ibrahim, Eman Abouzeid Abouzeid, Elsiraffy, Omar Ossama, Aboelela, Ahmed, Farag, Eman mohamed, Oshiba, Ahmed Mohamed, Emam, Omar Sameh, Attia, Alaa Mobarak, Laymouna, Moustafa A., Ghorab, Islam Abdelmonem, Mohammed, Mansour Mkayed, Soliman, Nourhan Akram, Ghaly, Khaled Abd elrahman, Sadek, Kareem, Elsherbiny, Mohamed, Saleh, Amr, Sheir, Hesham, Wafa, Tamer, Elmenam, Mohamed Abd, Abdelmaksoud, Sherif, Reda, Ahmed, Mansour, Islam, Elzohiri, Mohamed, Waseem, Basma, Elewaily, Mohamed, El-Ghazaly, Mohammed, Elhattab, Ahmad, Shalaby, Amr, Elsaied, Adham, Adawy, Ahmad, Sadek, Mirna, Ahmed, Mahmoud Abdelfattah, Herdan, Mohamed Omar, Elassall, Gena Mohamed Hamed, Mohammed, Azhar Arabi, Takrouney, Mohammed Hamada, Essa, Tarek Mohamed, Mahmoud, Ahmed Mokhtar, Saad, Alshaimaa M., Fouly, Mariam Albatoul Nageh, Ibrahim, Mahmoud abdelshakour, Nageh, Mohammad, Saad, Mahmoud M., Badr, Helmy, Fouda, Mohamed Fayez, Nofal, Ahmed Hassan, Almohamady, Hisham, Arafa, Mohamed Ahmed, Amad, Mohamed, Mansour, Mohamed Awad, O'Connor, Jennifer, O'Connor, Zachary, Anatole, Nzanzu, Nkunzimana, Elysé, Machemedze, Solomon, Dieudonné, Lemfuka, Appeadu-Mensah, William, Anyomih, Theophilus Teddy Kojo, Alhassan, Priscilla, Abantanga, Francis A., Michael, Vishal, Mary Koshy, Roshine, Raj, Ankit, Kumar, Vijay, PT, Sundeep, 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Saied, Tarek, Ahmed, Ahmed, Hazem, Essamilghi, Kamila Almabrouk Mohammed, Alfoghi, Mabroka, Abuhlega, Ma'aly A., Arrmali, Saddam, Abduljawad, Fatima Mousa, Alosta, Hasan Mustafa, Abuajaila, Abdulsalam, Abdelmutalib, Fakereldeen, Bashir, Fatma, Almengar, Inas, Annajjar, Mohammad hasan, Deyab, Abdelaziz, Elzowawi, Fathi, Krayem, Yousef, Drah, Weam, Meftah, Asma, Mohammed, Abobaker, Arrmalli, Lina Ali, Aljaboo, Hajir, Elayeb, Abdallah, Altomi, Mohamed, Altaweel, Ahmed, Tumi, Mohamed, Bazozi, Hana Milad, Shaklawoon, Aisha, Alglaib, Mohammed Meftah, Elkaloush, Abdullahn Abdousalam, Trainba, Sara, Swessi, Hisham, Alnaeri, Ali, Shnishah, Aya Essam, Mustufa, Hamassat, Gargum, Sondas Ali, Tarniba, Sara Ali, Shalluf, Hawa Ahmed, Shokri, Hajer Ali, Sarkaz, Taher L., Tababa, Osama, Elhadi, Ahmed, Naunova, Vesna Cvetanovska, Jovcheski, Laze, Kamilovski, Marjan, Gavrilovska-Brzanov, Aleksandra, Latiff, Zarina Abdul, Pauzi, Siti Farhan Moh, Osman, Marjmin, Lim, Felicia, Bakar, Ainal Huda Abu, Zaman, Azrina SK, Ishak, Shareena, Teo, Rufinah, Qi, Dr. Tammy Teoh Han, Othman, Mohd Yusran Bin, Zahari, Dato' Dr Zakaria bin, Hassan, Zulfitri bin Md, Shan, Cheah Hui, Lechmiannandan, Abhirrami, Tamaddun, Hafatin Fairos bt, Adanan, Mohd Fitri Shukri bin Mohamed, Abdullah, Mohd Yusof bin, Junyi, Wang, Nor, Mohd. Tarmizi Mohd, Noor, Wan Ruzaimie, Hassan, Mohd Razin bin, Dalek, Noor Fa'izatul Rahil Ambok, Hashim, Hidayah Hayati binti, Zarwawi, Ahmad Zulhisyam bin, Vellusamy, V Muthualhagi M, Yuen, Quah Soong, Kannessan, Hemasutha a/p, Ramli, Najua binti, Bujarimin, Ahmad Shafiee bin, Anntinea, Jessmine, Dass, Anthony, Khalid, Hazlina Mohd., Hanifah, Nur Atiqah binti Mohd, Jyun, Keily Wong Yue, Razak, Rahilah binti Abd, Naim, Nur Atifah binti Mohd, Hamzah, Siti Nur Aien binti Hamid, Vidal, Cristian R. 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Alkareem, Raghad mohammad abdu, Lahlooh, Raghad abdullateef, Halabi, Yasmeen Adly, Baker, Wisam, Almusleh, Tasneem Fathi Hasan, Tahyneh, Abdulraheem Adnan Abdulraheem, Atatri, Yazid yousef mahmoud, Jamie, Najlaa Abu, Massry, Nasrallah Ashraf Al, Lubbad, Walaa, A.Nemer, Ayoub, Alser, Mohammed, Salha, Aya Azmi Shehda, Alnahhal, Khaled, Elmzyyen, Aya Mahmoud, Ghabayen, Amir Talat Sheda, Alamrain, Abdulwhhab Ayman Abu, Al-Shwaikh, Samar H., Elshaer, Omar Adly, Shaheen, Nureddin, Fares, Jehad, Dalloul, Hisham, Qawwash, Anas, Jayyab, Mustafa abu, Ashour, Dina Ayman, Shaheen, Ahmad Ashraf, Naim, Samy Rafat Ramadan, Shiha, Eman Abu, Dammagh, Nagham Mohammed Al, Almadhoun, Walaa, Al-Salhi, Ashraf Ayman, Hammato, Abdalkarim Yhya, Salim, Jamal Mohammed, Hasanain, Doaa Khalil, Alwadia, Soha Marwan Salem, Nassar, Ismail, Al-Attar, Hala M., Alshaikhkhalil, Haya Abdulnasser Ali, Jamie, Yasmin Mohammed Khalil Abu, Ashour, Yara shareef, Alijla, Sharif S., Tallaa, Mohamed Anwer El, Abuattaya, Adham 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Virginie, Kohaut, Jules, Broch, Aline, Blanc, Thomas, Harper, Luke, Delefortrie, Thomas, Ballouhey, Quentin, Fourcade, Laurent, Grosos, Céline, Parmentier, Benoit, Levard, Guillaume, Grella, Maria Giovanna, Renaux Petel, Mariette, Grynberg, Lucie, Abbo, Olivier, Mouttalib, Sofia, Juricic, Mélodie, Scalabre, Aurelien, Haraux, Elodie, Rissmann, Anke, Krause, Hardy, Goebel, Peter, Patzer, Ludwig, Rolle, Udo, Schmedding, Andrea, Antunez-Mora, Alexandra, Tillig, Bernd, Bismarck, Sylvester von, Barbosa, Patricia Reis, Knorr, Christian, Stark, Domitille, Brunero, Marco, Avolio, Luigi, Manni, Francesco, Molinelli, Matilde, Guazzotti, Marinella, Raffaele, Alessandro, Romano, Piero Giovanni, Cavaiuolo, Silvia, Parigi, Gian Battista, Juhasz, Laszlo, Rieth, Anna, Strumila, Arunas, Dagilytė, Rūta, Liubsys, Arunas, Gurskas, Pranas, Malcius, Dalius, Mikneviciute, Agne, Vinskaite, Asta, Barauskas, Vidmantas, Vierboom, Liam, Hall, Timothy, Beasley, Spencer, Goddard, Lucy, Stringer, Mark, Weeratunga, Naveen, Adams, Stephen, Cama, Jitoko, Wong, Marilyn, Jayaratnam, Sridharan, Kukkady, Askar, Samarakkody, Udaya, Gerus, Sylwester, Patkowski, Dariusz, Wolny, Agnieszka, Koszutski, Tomasz, Tobor, Szymon, Osowicka, Marta, Czauderna, Piotr, Wyrzykowski, Dariusz, Garnier, Hanna, Anzelewicz, Stefan, Marta, Osowicka, Knurowska, Agata, Weiszewsk, Alicja, Grabowski, Andrzej, Korlacki, Wojciech, Pasierbek, Michal, Wolak, Przemyslaw, Piotrowska, Aneta, Roszkiewicz, Anna, Kalicińsk, Piotr, Trypens, Agata, Kowalewsk, Grzegorz, Sigalet, David, Alsaied, Amer, Ali, Mansour, Alsaggaf, Ameen, Ghallab, Alaa, Owiwi, Yazeed, Zeinelabdeen, Ali, Fayez, Mohamed, Atta, Ahmed, Zidan, Mazen, Radwan, Asaad saleh, Shalaby, Hanin, Abdelbaqi, Reem, Alattas, Khalid, Kano, Yar, Sindi, Omar, Alshehri, Abdullah, Altokhais, Tariq, Alturki, Fahad, Almosaibli, Mohammad, Krisanova, Dasha, Abbas, Wisam, Yang, Hee-Beom, Kim, Hyun-Young, Youn, Joong Kee, Chung, Jae Hee, Cho, Seok Hyeon, Hwang, In ji, Lee, Ju yeon, Song, Eung song, Arboleda, Jenny, Ruiz de Temiño Bravo, Mercedes, Siles Hinojosa, Alexander, García, Miriam, Casal Beloy, Isabel, Oliu San Miguel, Detlef, Molina Vazquez, Maria Elena, Alonso, Verónica, Sanchez, Alberto, Gomez, Oscar, Carrillo, Isabel, Wester, Tomas, Mesas Burgos, Carmen, Hagander, Lars, Salö, Martin, Omling, Erik, Rudolfson, Niclas, Granéli, Christina, Arnadóttir, Helena, Grottling, Emma, Abrahamsson, Kate, Gatzinsky, Vladimir, Dellenmark Blom, Michaela, Borbonet, Daniel, Puglia, Paul, Jimenez Morejon, Vinicio, Acuna, Gaston, Moraes, Mario, Chan, Jonathan, Brahmamdam, Pavan, Tom, Alan, Sherer, Karen, Gonzales, Brandy, Cunningham, Aaron, Krishnaswami, Sanjay, Baertschiger, Reto, Leech, Mary, Williams, Regan, Camp, Lauren, Gosain, Ankush, Mora, Maria, Lyttle, Bailey D., Chang, Jeremy, McColl Makepeace, Lydia, Fowler, Kathryn L, Mansfield, Sara, Hodgman, Erica, Amaechi, Chukwubinyelum, Beres, Alana, Pernik, Mark N., Dosselman, Luke J., Almasri, Murad, Jain, Sunil, Modi, Varun, Fernandez Ferrer, Marianelly, Coon, John, Gonzalez, Joann, Honhar, Medhavi, Ruzgar, Nensi, Coghill, Griffin, Ullrich, Sarah, Cheung, Maija, Løfberg, Katrine, Greenberg, Jodie, Davenport, Kate, Gadepalli, Samir, Fox, Sarah, Johnson, Stephanie, Pilkington, Mercedes, Hamilton, April, Lin, Nicole, Sola, Juan, Yao, Yang, Davis, Jenna Kylene, Langer, Monica, Vacek, Jonathan, Abdullah, Fizan, Khlevner, Julie, Middlesworth, William, Levitt, Marc, Ahmad, Hira, Siddiqui, Sabina M, Bowder, Alex, Derks, Terry, Amoabin, Afua Amoabin, Pinar, Brooke, Owusu-Sekyere, Frank, Saousen, Benmanseur, Naidoo, Rasika, Karamustafic, Azra, Oliveira, Danielle Paula de, Motter, Sarah Bueno, Andrade, Jerhy, Šafus, Antonín, Langley, Jason, Wilke, Alexandra, Deya, Corazone, Murtadi, Habib Mansour, Berzanskis, Mindaugas, Calistus, Nwachukwu, Ajiboye, Olalekan S., Felix, Michael, Olabisi, Osagie O, Erçin, Seçil, Muradi, Teymursha, Burks, Stephen S., Lerma, Sergio, Jacobson, Jillian, Calancea, Calin, Valerio-Vazquez, Rafael, Sikwete, Guigui, Sekyere, Owusu, Mbonisweni, Akhona, Syed, Shahnoor, Hyeon, Cho Seok, Pajouhandeh, Fatemeh, and Kunfah, Sheba Mary Pognaa

Abstract

Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality.

Published
2021
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24. Ultrasound-Stimulated PVA Microbubbles for Adhesive Removal from Cellulose-Based Materials: A Groundbreaking Low-Impact Methodology

Author

D’Andrea, Alessia, Severini, Leonardo, Domenici, Fabio, Dabagov, Sultan, Guglielmotti, Valeria, Hampai, Dariush, Micheli, Laura, Placidi, Ernesto, Titubante, Mattia, Mazzuca, Claudia, Paradossi, Gaio, and Palleschi, Antonio

Abstract

In this work, we shed new light on ultrasound contrast agents applied to the field of cultural heritage as an invaluable fine-tune cleaning tool for paper artworks. In this context, one of the primary and challenging issues is the removal of modern adhesives from paper artifacts. Modern adhesives are synthetic polymers whose presence enhances paper degradation and worsens its optical features. A thorough analytical and high-spatial-resolution combined study was successfully performed to test the capability of poly(vinyl alcohol)-based microbubbles stimulated by a proper noninvasive 1 MHz ultrasound field exposure in removing these adhesives from paper surfaces, in the absence of volatile invasive and toxic chemicals and without damaging paper and/or leaving residues. We demonstrate that poly(vinyl alcohol)-shelled microbubbles are suitable for interacting with paper surfaces, targeting and boosting in a few minutes the nondamaging removal of adhesive particles from paper samples thanks to their peculiar shell composition together with their ultrasound dynamics.

Published
2021
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25. Haematological and protein profile of goat rodeo in extensive productions of different regions in the province of Salta, Argentina

Author

Mazzuca Pizetti, Analía Josefina, Sarmiento, Ricardo Oscar, Pintos, Lucía Alejandra, Trova, Gabriela Beatríz, Binda, Javier Alejandro, and Sánchez Negrette, Olga

Abstract

ABSTRACTThe proposal of this study was to determine the haematological and protein parameters of goats raised extensively in three regions of different orography and climate in the province of Salta. Haematological parameters were determined: haematocrit (Hct), red blood cell (RBC), mean corpuscular volume (MCV), heamoglobin (Hb), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), white blood cell (WBC), lymphocyte (L), neutrophil (N), eosinophil (E), basophil (B) and monocyte (M), and serological parameters: proteins, albumin and A/G ratio. Blood samples were taken by the jugular puncture from 61 animals of the mountain range region, 253 from the region of the valleys and Sub-Andean Mountain and 299 from the Chaco region. In general, the values obtained are within the reference parameters of the goat species. The study of one-way analysis of variance (ANOVA) showed there was a significant effect of altitude on the following parameters: Hct, Hg, being higher in the animals from the mountain range environment. The values determined contribute to the knowledge of the reference range of haematological and protein values for goat raised in Salta, and can be used as health control.

Published
2021
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26. Experimental Evidence of the Coexistence of Proper Magnetic and Structural Incommensurability on the [CH3NH3][Ni(COOH)3] Compound

Author

Cañadillas-Delgado, Laura, Mazzuca, Lidia, Fabelo, Oscar, Rodríguez-Carvajal, Juan, and Petricek, Vaclav

Abstract

The present work is dedicated to characterization of the structural phase transition and incommensurate magnetic structure of the [CH3NH3][Ni(COOH)3] (1) perovskite-like metal–organic compound. The structural and magnetic characterization has been performed through variable-temperature single-crystal and powder neutron diffraction. Compound 1crystallizes in the orthorhombic Pnmaspace group at room temperature. Below 84 K, a new phase has been observed. The occurrence of new reflections, which can be indexed with a wavevector along the caxis [q= 0.1426(2)c*], suggests the occurrence of an incommensurately modulated crystal structure. The structure was determined using the superspace group formalism on the Pnma(00γ)0s0 space group. This incommensurate phase remains unchanged with a decrease of the temperature up to the base temperature (ca. 2 K). Moreover, the magnetic susceptibility data, collected under zero-field-cooled and field-cooled conditions at different applied magnetic fields, show that compound 1exhibits antiferromagnetic behavior below 34 K. In the current paper, we have confirmed that compound 1presents the coexistence of nuclear and proper magnetic incommensurability below TN.

Published
2020
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28. A completely green approach to the synthesis of dendritic silver nanostructures starting from white grape pomace as a potential nanofactory.

Author

Carbone, Katya, Paliotta, Mariano, Micheli, Laura, Mazzuca, Claudia, Cacciotti, Ilaria, Nocente, Francesca, Ciampa, Alessandra, and Dell'Abate, Maria Teresa

Abstract

A simple, eco-friendly, cost-effective and rapid microwave-assisted method has been developed to synthetize dendritic silver nanostructures, composed of silver nanoparticles (AgNPs), using white grape pomace aqueous extract (WGPE) as both reducing and capping agent. With this aim, WGPE and AgNO 3 (1 mM) were mixed at different ratio, and microwave irradiated at 700 W, for 40 s. To understand the role of bioactive compounds involved in the green synthesis of AgNPs, preliminary chemical characterization, FT-IR analysis and 1H NMR metabolite profiling of WGPE were carried out. The effects of bioactive extract concentration and stability over time on AgNPs formation were also evaluated. WGPE-mediated silver nanostructures were then characterized by UV–vis, FTIR analyses, and scanning electron microscopy. Interestingly, the formation of dendritic nanostructures, originated from the self-assembly of Ag rounded nanoparticles (average diameter of 33 ± 6 nm), was observed and ascribed to the use of microwave power and the presence of organic components within the used WGPE, inducing an anisotropic crystal growth and promoting a diffusion-limited aggregation mechanism. The bio-dendritic synthetized nanostructures were also evaluated for potential applications in bio-sensing and agricultural fields. Cyclic voltammetry measurements in 0.5 M phosphate + 0.1 M KCl buffer, pH 7.4 showed that green AgNPs possess the electroactive properties typical of AgNPs produced using chemical protocol. The biological activity of synthetized AgNPs was evaluated by in-vitro antifungal activity against F. graminearum. Additionally, a phytotoxicity evaluation of synthetized green nanostructures was carried out on wheat seed germination. Results highlighted the potential of WGPE as green agent for bio-inspired nanomaterial synthesis, and of green Ag nanostructures, which can be used as antifungal agent and in biosensing applications. [ABSTRACT FROM AUTHOR]

Published
2019
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30. How technology can help in oncologic patient management during COVID-19 outbreak.

Author

Mercantini, Paolo, Lucarini, Alessio, Mazzuca, Federica, Osti, Mattia Falchetto, and Laghi, Andrea

Subjects
COVID-19 pandemic, SARS-CoV-2, MEDICAL practice, MEDICAL research
Abstract

Keywords: Gastrointestinal cancer; Multidisciplinary team; Oncology; COVID-19 EN Gastrointestinal cancer Multidisciplinary team Oncology COVID-19 1189 1191 3 06/04/20 20200601 NES 200601 Every country in the world is now facing the new pandemic disease caused by the SARS-CoV-2 virus, which is known to spread using droplets. We would like to briefly report how the GI oncology MultiDisciplinary Team (MDT) of Sant'Andrea University Hospital, Sapienza University of Rome, Italy, reacted to the COVID-19 outbreak thanks to the implementation of a new technology. [Extracted from the article]

Published
2020
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31. Is fatigue a cause of work disability in Systemic Lupus Erythematosus? Results from a systematic literature review.

Author

BASTA, F., MARGIOTTA, D. P. E., VADACCA, M., VERNUCCIO, A., MAZZUCA, C., AFELTRA, A., and DIAMANTI, A. PICCHIANTI

Abstract

OBJECTIVE: Fatigue affects the almost totality of Systemic Lupus Erythematous (SLE) patients impairing physical function and leading to a strong reduction of health-related quality of life (HRQoL). Similarly, SLE patients have an increased rate of work loss and work limitations. The aim of our paper was to systematically assess the relationship between fatigue and work disability in SLE. MATERIALS AND METHODS: We performed a systematic review using the terms "fatigue" and "employment", "work disability", "work impairment", "presenteeism" and "absenteeism". RESULTS: 19 studies were identified. Fatigue was involved in the development of work loss. In employed patients, fatigue led to impairment of work productivity and presenteeism with a parallel increase of both direct and indirect health costs. Fatigue also affected parenting and household productivity. CONCLUSIONS: An adequate control of fatigue could improve physical and work performance in SLE patients thus reducing rates of work loss. [ABSTRACT FROM AUTHOR]

Published
2018

33. Patients with asthma have reduced functional capacity and sedentary behavior

Author

Reimberg, Mariana Mazzuca, Pachi, Jessyca Rodrigues Selman, Scalco, Rebeca Souza, Serra, Andrey Jorge, Fernandes, Leandro, Politti, Fabiano, Wandalsen, Gustavo Falbo, Solé, Dirceu, Dal Corso, Simone, and Lanza, Fernanda Cordoba

Abstract

The modified shuttle test is a field test that avoids the ceiling effect, and there are no reports of a multidimensional assessment concerning physical activity in asthmatic patients. Thus, the aim was to evaluate functional capacity by MST, additionally to perform a multidimensional assessment as physical activity in daily life, muscle strength, and cytokine levels in children and adolescents with asthma, and to correlate these variables.

Published
2020
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34. Patients with asthma have reduced functional capacity and sedentary behavior

Author

Reimberg, Mariana Mazzuca, Pachi, Jessyca Rodrigues Selman, Scalco, Rebeca Souza, Serra, Andrey Jorge, Fernandes, Leandro, Politti, Fabiano, Wandalsen, Gustavo Falbo, Solé, Dirceu, Dal Corso, Simone, and Lanza, Fernanda Cordoba

Abstract

The modified shuttle test is a field test that avoids the ceiling effect, and there are no reports of a multidimensional assessment concerning physical activity in asthmatic patients. Thus, the aim was to evaluate functional capacity, physical activity in daily life, muscle strength, and cytokine levels in children and adolescents with asthma, and to correlate these variables.

Published
2020
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35. Obstructive sleep apnea and comorbidities: a dangerous liaison

Author

Bonsignore, Maria, Baiamonte, Pierpaolo, Mazzuca, Emilia, Castrogiovanni, Alessandra, and Marrone, Oreste

Abstract

Obstructive sleep apnea (OSA) is a highly prevalent disease, and is traditionally associated with increased cardiovascular risk. The role of comorbidities in OSA patients has emerged recently, and new conditions significantly associated with OSA are increasingly reported. A high comorbidity burden worsens prognosis, but some data suggest that CPAP might be protective especially in patients with comorbidities. Aim of this narrative review is to provide an update on recent studies, with special attention to cardiovascular and cerebrovascular comorbidities, the metabolic syndrome and type 2 diabetes, asthma, COPD and cancer. Better phenotypic characterization of OSA patients, including comorbidities, will help to provide better individualized care. The unsatisfactory adherence to CPAP in patients without daytime sleepiness should prompt clinicians to examine the overall risk profile of each patient in order to identify subjects at high risk for worse prognosis and provide the optimal treatment not only for OSA, but also for comorbidities.

Published
2019
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36. Impact of tumor site on the prognosis of small bowel adenocarcinoma

Author

Falcone, Rosa, Romiti, Adriana, Filetti, Marco, Roberto, Michela, Righini, Riccardo, Botticelli, Andrea, Pilozzi, Emanuela, Ghidini, Michele, Pizzo, Claudio, Mazzuca, Federica, and Marchetti, Paolo

Abstract

Background: Because of a lack of large-scale prospective studies there is no clear indication about the management of patients with small bowel adenocarcinoma (SBA). This study evaluated clinical outcome of patients diagnosed with SBA at our institution.Methods: Clinicopathologic features, treatments, and clinical outcome of patients diagnosed with SBA between 2006 and 2017 were retrospectively analyzed. Median time of survival was calculated and compared using the log-rank test. Multivariate Cox regression was used to test independence of significant factors in univariate analysis.Results: Forty patients were included in the study; the majority (82.5%) had a tumor in the duodenum (including ampulla of Vater) and an early stage disease at the diagnosis. Median overall survival (OS) in the whole study population was 26.5 months. Patients with a tumor of the lower part of the small intestine (jejunum, ileum, and appendix) showed a better OS compared with that of patients with upper SBA (40 months vs 26 months, respectively; P=0.09). Primary tumor site and stage were independent predictors of OS.Conclusions: Our results suggest a prognostic role for the primary tumor site. This finding deserves to be further investigated to ensure better classification as well as more effective management strategies for SBA.

Published
2019
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37. An evaluation of Alberta pharmacists’ practices, views and confidence regarding prescription drug abuse and addiction within their practice setting

Author

Necyk, Candace, Cor, Ken, Mazzuca, Arianna, and Meleshko, Lauren

Abstract

Background: Pharmacists play an important role in managing patients with prescription drug abuse and addiction (PDAA). The objective of this study was to explore Alberta pharmacists’ practices, views and confidence in the management of patients at risk of or living with PDAA in their practice setting.Methods: A 26-question online questionnaire was distributed to 4261 pharmacists across Alberta, of whom 656 (15%) participated. The questionnaire consisted of 17 multiple-choice, 6 multipart and 3 free-response questions. Questionnaire responses were collected and analyzed in Qualtrics.Results: Sixty-six percent (n= 408) of pharmacists indicated that PDAA was prevalent in their practice setting, with 55% (n= 340) of respondents encountering more than 6 patients with suspected or known PDAA a month. Thirty-five percent (n= 198) of pharmacists indicated they were moderately confident at identifying patients with potential PDAA. However, 41% (n= 235) of the pharmacists indicated that they only discuss PDAA with identified patients less than half of the time. Pharmacists lacked confidence in their ability to discuss PDAA treatment options with their patients as well as collaborate with addiction treatment facilities. Lack of training or knowledge in PDAA (48%) and uncertainty of how to initiate discussion or effectively communicate with patients about PDAA (39%) were identified as barriers that significantly or very significantly hindered respondents from managing PDAA in their practice.Conclusions: Although many pharmacists are moderately confident in identifying patients with potential PDAA, several barriers hinder intervention. Providing pharmacists with additional training and resources may better equip them to manage PDAA within their practice settings. Can Pharm J (Ott)2019;152:xx-xx.

Published
2019
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38. Ethnic differences in body composition, sociodemographic characteristics and lifestyle in people with type 2 diabetes mellitus living in Italy

Author

Toselli, Stefania, Gualdi-Russo, Emanuela, Mazzuca, Paolo, and Campa, Francesco

Abstract

This study aimed to compare immigrants and Italian natives with type 2 diabetes mellitus (DM2) in terms of anthropometric parameters and lifestyle-related characteristics and to investigate the relationship between ethnicity and glycemic control in men and women with DM2 living in Italy. The sample included 100 immigrants (55 Albanians and 45 Africans) and 100 Italians, followed by the Public Health Clinics of Rimini. The association of ethnicity with sex, socioeconomic status, anthropometric and hematological characteristics, and lifestyle were examined. In addition, differences among groups in glycemic control were evaluated. Among males, African participants presented significantly lower values than other groups in adiposity parameters and triglycerides. The highest percentage of obesity and of normal weight was found in Italians and in Africans, respectively. Among females, there were scanty differences, but Italians presented higher WHR values than the other groups. No statistical differences appeared in hematological parameters among groups. There were no significant differences in glycemic control among groups and sexes. Also considering the differences between subjects with optimal (L) or nonoptimal (H) glycemic control, the differences in lifestyle, anthropometric, and hematological variables remained scarce. Among all groups, significantly higher values of glucose were detected in H than in L. A similar condition appeared for triglycerides in males. Immigrant and native Italian diabetics did not present any difference in their clinical characteristics, but Italians generally presented worst lifestyle habits. The percentage of subjects with poor metabolic control of diabetes was not low, but similar in immigrants and natives. There is a clear necessity to acquire knowledge of diabetes in immigrants through better data collection, especially in view of the scarcity of epidemiological studies evaluating the importance of this problem in EU countries.The percentage of subjects with poor metabolic control of diabetes is high, and generally comparable between immigrants and natives.

Published
2019
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39. Empirically Corrected Electronic Structure Calculations Applied to the Enthalpy of Combustion Physical Chemistry Laboratory

Author

Mazzuca, James W., Downing, Alexis R., and Potter, Christopher

Abstract

A method for using electronic structure calculations to predict the standard molar enthalpy of combustion for hydrocarbons is presented. In this approach, simple geometry optimizations can be used to accurately compute the enthalpy of combustion within 3% of the experimental value using Hartree–Fock, MP2, or virtually any functional in density functional theory calculations. This approach keeps the electronic structure calculations conceptually simple and computationally cheap, making this method accessible for a teaching lab with only minimal computational resources. This method is especially applicable to the bomb calorimeter experiment that typically appears in the physical chemistry teaching laboratory, and we provide an example of how our electronic structure calculations can be integrated into the laboratory curriculum.

Published
2019
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40. Molecular Sponge: pH-Driven Reversible Squeezing of Stimuli-Sensitive Peptide Monolayers

Author

Messina, Grazia M. L., Di Napoli, Benedetta, De Zotti, Marta, Mazzuca, Claudia, Formaggio, Fernando, Palleschi, Antonio, and Marletta, Giovanni

Abstract

The cyclic change of structure, thickness, and density, with pH switching from acidic (pH = 3) to basic (pH = 11) condition, has been revealed for chemisorbed monolayers of the peptide Lipo-Aib-Lys-Leu-Aib-Lys-Lys-Leu-Aib-Lys-Ile-Lol, a trichogin GA IV-analogue carrying Lys residues instead of Gly ones at positions 2, 5, 6, and 9, while a homologous peptide not containing Lys residues does not show any response to pH changes. Experimental and theoretical results, obtained by means of quartz crystal microbalance with dissipation monitoring, surface plasmon resonance, nanoplasmonic sensing technique, Fourier transform infrared-reflection attenuated spectroscopy and dynamic force spectroscopy, and molecular dynamics simulations provide detailed information on the overall monolayer structure changes with pH, including the analysis of the intra- and interchain peptide dynamics, the structure of the peptide layer/water/solid interface, as well as the position and role of solvation and nonsolvation water. The observed stimuli-responsive behavior of L1 peptide monolayers is accounted in terms of the occurrence of a pH-induced wetting/dewetting process, due to the pH-induced switching of the hydrophilic character of charged lysine groups to hydrophobic one of the same uncharged groups, along the peptide chain. This behavior in turn promotes the collective change of the aggregation state of the peptide chains. The present results may pave the way to critically reexamine the mechanism of stimuli-responsive systems.

Published
2019
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41. Adaptive responses along a depth and a latitudinal gradient in the endemic seagrass Posidonia oceanica

Author

Jahnke, Marlene, D’Esposito, Daniela, Orrù, Luigi, Lamontanara, Antonella, Dattolo, Emanuela, Badalamenti, Fabio, Mazzuca, Silvia, Procaccini, Gabriele, and Orsini, Luisa

Abstract

Seagrass meadows provide important ecosystem services and are critical for the survival of the associated invertebrate community. However, they are threatened worldwide by human-driven environmental change. Understanding the seagrasses’ potential for adaptation is critical to assess not only their ability to persist under future global change scenarios, but also to assess the persistence of the associated communities. Here we screened a wild population of Posidonia oceanica, an endemic long-lived seagrass in the Mediterranean Sea, for genes that may be target of environmental selection, using an outlier and a genome-wide transcriptome analysis. We identified loci where polymorphism or differential expression was associated with either a latitudinal or a bathymetric gradient, as well as with both gradients in an effort to identify loci associated with temperature and light. We found the candidate genes underlying growth and immunity to be divergent between populations adapted to different latitudes and/or depths, providing evidence for local adaptation. Furthermore, we found evidence of reduced gene flow among populations including adjacent populations. Reduced gene flow, combined with low sexual recombination, small effective population size, and long generation time of P. oceanicaraises concerns for the long-term persistence of this species, especially in the face of rapid environmental change driven by human activities.

Published
2019
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42. Intermediate-catalyzed mechanism for the bromination of alkenes.

Author

Mazzuca, James W., Reilly, Kayleigh S., Weber, Byron P., Spaulding, Brayden T., and Gottschalk, Grace M.

Subjects
ALKENES, DENSITY functional theory, BROMINE, DOUBLE bonds
Abstract

A mechanism is proposed for the fast product-forming step of the bromination of alkenes in which a bromonium ion catalyzes the formation of a vicinial dihalide product. Energy profiles for this step of the syn and anti addition of molecular bromine to alkenes with various levels of substitution at the double bond were investigated using density functional theory calculations. Our calculations were able to reproduce experimentally observed trends in reactivity as a function of double-bond substitution. We additionally demonstrate that the anti addition is kinetically more favorable and results in the trans product, in agreement with experiment. The mechanism described here provides another route to the halogenated product which does not necessitate the formation of a new counteranion for each product molecule that is formed, and the highly exothermic nature of this step could serve to drive other reactions forward in a similar way. [Display omitted] • Mechanism for the product-forming step of the bromination of alkenes. • Bromonium ion intermediate acts as a catalyst. • Double-bond substitution can inhibit product formation. • Anti addition is preferred over syn addition. • Calculated trends in agreement with experimental observations. [ABSTRACT FROM AUTHOR]

Published
2023
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43. The stock price of European insurance companies: What is the role of ESG factors?

Author

Di Tommaso, Caterina and Mazzuca, Maria

Abstract

• We study the effect of ESG ratings on the value of insurance firms using cumulative abnormal returns (CAR) as a proxy for corporate value. To measure the stock market's reaction to the upgrade or downgrade announcements, we apply an event study methodology (MacKinlay, 1997). We first identify all insurance companies included in Refinitiv ESG Europe, we extract the daily time series of ESG ratings from Refinitiv ESG Europe from 2011 to 2021. For each insurance company, we retrieved the corresponding stock daily price denominated in euros from Datastream. Our final dataset is composed of 56 insurance companies located in 15 countries. We identify 210 ESG rating announcements divided into 72 downgrades and 138 upgrades. • We focus on the insurance industry for two main reasons: i) because this sector plays a key-role in the transition to a low-carbon economy; ii) because the physical risks related to global warming can have a direct impact on the insurance industry due to their special activity. We contribute to the limited literature on the impact of ESG factors on insurance stock prices and on environmental disclosure in the insurance sector. • Our results show that the impact of ESG rating announcements on stock prices varies over time. The market was more sensitive during the Pre-Paris period (2015-2016). This confirms the significance of this Agreement in shaping investors' perceptions of the companies' sustainability performance and the importance of considering the broader socio-political context in which ESG rating announcements are made. • We find that the environmental pillar score is the most important factor for investors, with a greater reaction to a downgrade in this score than in the social or governance pillars. These findings could help raise insurers' awareness of the need to manage climate-related risks, strategically and from a disclosure perspective. • Our findings have implications for rating agencies, policymakers, and market participants. Rating agencies should review their methodologies to consider both the potential distortive effect of downgrades and the specificity of sectors. Increased credibility and transparency of ESG ratings could help promote efficient mobilization of capital in support of climate-related goals (OECD, 2022). Our findings also support policy makers and regulators in their efforts to improve market efficiency by confirming the effectiveness of public intervention mechanisms. It is essential to continue promoting concrete strategies and actions to promote ESG culture and objectives. Market participants should consider the potential impact of ESG rating announcements on the value of insurers. The results demonstrate the presence and functioning of the market discipline desired by the regulators. This discipline is capable of sanctioning or rewarding insurance companies, also in the context of climate risk management. The study investigates the effect of environmental, social, and governance (ESG) ratings on the stock price of European insurance companies using the event study methodology. ESG ratings play an important role in the pricing of insurance firms, and an upgrade results in a stock price increase, while a downgrade leads to a decrease. The market is particularly responsive to ESG rating upgrades and downgrades during the Pre-Paris period, suggesting that ESG ratings can have a significant impact on the equilibrium and efficiency of the stock market. ESG factors are important in investment decision-making and in promoting sustainable business practices. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Behavior of a Peptide During a Langmuir–Blodgett Compression Isotherm: A Molecular Dynamics Simulation Study

Author

Di Napoli, Benedetta, Mazzuca, Claudia, Conflitti, Paolo, Venanzi, Mariano, and Palleschi, Antonio

Abstract

A detailed characterization of the behavior of the amphiphilic antimicrobial peptide Trichogin GA IV (TRIC) at the air/water interface during a Langmuir–Blodgett (LB) isotherm is reported. By means of molecular dynamics simulations, experimental data are explained in terms of the conformational changes and aggregate features adopted by TRIC. We show that, due to compression, different structural changes occur: initially formed drop-like aggregates coalesce, forming nanofibers; on increasing the surface tension further, these nanofibers constitute a web-like structure in which meshes are filled by water pools. During these transitions, the peptide chains lie almost parallel to the surface mostly adopting a helical conformation. At high peptide concentration, reaching the maximum of the allowed surface pressure, a monolayer of TRICs in nonhelical conformation and vertically aligned with respect to the air/water interface is formed.

Published
2024
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45. Hydrolates and Gellan: An Eco-innovative Synergy for Safe Cleaning of Paper Artworks.

Author

Di Vito, Maura, Bellardi, Maria Grazia, Colaizzi, Piero, Ruggiero, Daniele, Mazzuca, Claudia, Micheli, Laura, Sotgiu, Silvia, Iannuccelli, Simonetta, Michelozzi, Marco, Mondello, Francesca, Mattarelli, Paola, and Sclocchi, Maria Carla

Subjects
PRESERVATION of paper art, GELLAN gum, ESSENTIAL oils, CLEANING, FUNGAL growth, DILUTION
Abstract

The gellan hydrogel is used as a cleaning agent for paper artworks. The purposes of this work were to give the gellan hydrogel both a microbial resistance and a cytocidal action against the biodeteriogens using hydrolates. Broth microdilution assays were performed to identify the fungicidal action of 16 hydrolatesvs3 fungal strains. The study concerned the Minimal Fungicidal Concentration and pH, colour, and ultra-structural variations on all paper samples, by placing them in contact with GELYD (GELlan + hYDrolat). Thein vitrotests showed that eight out of 16 hydrolates strongly inhibited fungal growth, but only two of them (Monarda fistulosa,Citrus aurantiumsubspamara) showedin situfungicidal action. Data indicate a new and interesting eco-innovative use of hydrolates, since GELYD is able not only to clean paper artworks, but also to kill the fungal cells present on paper that are potentially harmful for paper and operators. [ABSTRACT FROM AUTHOR]

Published
2018
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46. Forensic investigation of a failed connecting rod from a motorcycle engine.

Author

Bari, K., Rolfe, A., Christofi, A., Mazzuca, C., and Sudhakar, K.V.

Subjects
MOTORCYCLE engines, ROOT cause analysis, SCANNING electron microscopes
Abstract

In the present work, a failed connecting rod from a motorcycle engine was investigated for the root cause of and possible mechanisms leading to its premature failure. In addition to finding the root cause, the expectation from this study was to possibly improve the existing designs or practices to avoid similar failures in future. These results were validated using a finite element analysis (FEA) simulation. A Scanning Electron Microscope was used for investigating the mechanisms of fracture modes, optical microscopy for studying the microstructures and visual inspection were primarily utilised to determine the root cause of the failure. In conclusion, it was determined that the root cause for the premature failure of the connecting rod was the presence of scale build-up inclusions, which led to micro cracking during fatigue loading of the component. [ABSTRACT FROM AUTHOR]

Published
2017
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48. Systemic Chemotherapy for Advanced Rare Pancreatic Histotype Tumors

Author

Brunetti, Oronzo, Aprile, Giuseppe, Marchetti, Paolo, Vasile, Enrico, Casadei Gardini, Andrea, Scartozzi, Mario, Barni, Sandro, Delfanti, Sara, De Vita, Fernando, Di Costanzo, Francesco, Milella, Michele, Cella, Chiara Alessandra, Berardi, Rossana, Cataldo, Ivana, Scarpa, Aldo, Basile, Debora, Mazzuca, Federica, Graziano, Giusi, Argentiero, Antonella, Santini, Daniele, Reni, Michele, Cascinu, Stefano, and Silvestris, Nicola

Published
2018
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50. Varus malalignment negates the structure-modifying benefits of doxycycline in obese women with knee osteoarthritis.

Author

Mazzuca SA, Brandt KD, Chakr R, Lane KA, Mazzuca, S A, Brandt, K D, Chakr, R, and Lane, K A

Abstract

Objective: To estimate the extent to which varus malalignment, a source of abnormal intra-articular stresses in the medial tibiofemoral compartment and risk factor for progression of knee osteoarthritis (OA), may have diminished the structure-modifying benefit of doxycycline in knee OA.Methods: Post hoc treatment group comparisons from a randomized, placebo-controlled trial of the effect of doxycycline (100mg, twice daily) on medial joint space narrowing (JSN) in subgroups of varus and non-varus OA knees. Subjects (N=379 with X-ray follow-up) were obese 45-64-year-old women with unilateral knee OA at baseline. JSN was measured manually in semiflexed anteroposterior (AP) radiographs acquired with standardized fluoroscopic positioning. The anatomic-axis angle (AAA) was measured in each baseline radiograph and transformed to an estimate of the mechanical-axis angle (MAA(est)) using a validated regression equation. Knees with MAA(est)<178 degrees were classified as varus.Results: In our original comparison with placebo, doxycycline slowed the rate of medial JSN in OA knees by 38% at 16 months and by 33% at 30 months. Among non-varus OA knees, 16-month JSN in the doxycycline group was 44% slower than in the placebo group (0.09 vs 0.16 mm/year, P=0.080), and 39% slower at month 30 (0.10 vs 0.17 mm/year, P=0.026). JSN in varus knees (0.20-0.27 mm/year) was more rapid than in non-varus knees (P=0.083) and unaffected by doxycycline.Conclusion: Varus malalignment negated the slowing of structural progression of medial-compartment OA by doxycycline. To our knowledge, this is the first report documenting that static varus angulation can negate a pharmacologic structure-modifying effect. [ABSTRACT FROM AUTHOR]

Published
2010
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