212 results on '"Martini, M."'
Search Results
2. Investigating the Impact of the Glycolipid Content on Aurein 1.2 Pores in Prokaryotic Model Bilayers: A Coarse-Grain Molecular Dynamics Simulation Study.
- Author
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Balatti, G. E., Martini, M. F., and Pickholz, M.
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- 2023
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3. Aristotle - Ἀριστοτέλης (ARISTOTÉLĒS, 384/3- 322/1 BCE) The revelation of tuberculosis in his zoological works
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Cilione, M., Martini, M., Zampieri, F., Riccardi, N., Brigo, F., and Gazzaniga, V.
- Abstract
ABSTRACTOne of the most challenging issues with the sources of ancient medicine is to be able to identify the correspondence between the diseases we know today and those reported in ancient medical texts. Ancient diseases’ definitions rarely help us, and the symptoms described often correspond to more than one disease. This is especially true about tuberculosis, a disease that historians of medicine habitually associates with the Greek words phthi(n)o (φθίνω), verb, phthisis/phthoe (φθίσις/φθόη), noun, phthinodes/phthisikos (φθινώδης/φθισικός), adjective, all etymologically linked to an Indo-European root that expresses the idea of consumption in a broad sense. This article aims to analyze a group of Greek words, branchos/branchia (βράγχος/βράγχια), krauros/kraurao (κραῦρος/κραυράω), and katarreo (καταρρέω), that appear in nosological contexts very close to the infectious disease that today we call tuberculosis. Moreover, the paper aims to focus on the transmission pathways of TB being via animal-human contact and some ancient strategies to cure it. The symptoms, transmission pathways and therapeutic approach of tuberculosis belong to a homogeneous pathological picture that emerges from a set of texts that date back to the period between the fifth century BC and the second century AD.
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- 2023
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4. Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy
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Barutta, F., Bellini, S., Kimura, S., Hase, K., Corbetta, B., Corbelli, A., Fiordaliso, F., Bruno, S., Biancone, L., Barreca, A., Papotti, M.G., Hirsh, E., Martini, M., Gambino, R., Durazzo, M., Ohno, H., and Gruden, G.
- Abstract
ABSTRACTPodocyte injury leading to albuminuria is a characteristic feature of diabetic nephropathy (DN). Hyperglycemia and advanced glycation end products (AGEs) are major determinants of DN. However, the underlying mechanisms of podocyte injury remain poorly understood. The cytosolic protein TNFAIP2/M-Sec is required for tunneling nanotubes (TNTs) formation, which are membrane channels that transiently connect cells, allowing organelle transfer. Podocytes express TNFAIP2 and form TNTs, but the potential relevance of the TNFAIP2-TNT system in DN is unknown. We studied TNFAIP2 expression in both human and experimental DN and the renal effect of tnfaip2deletion in streptozotocin-induced DN. Moreover, we explored the role of the TNFAIP2-TNT system in podocytes exposed to diabetes-related insults. TNFAIP2 was overexpressed by podocytes in both human and experimental DN and exposre of podocytes to high glucose and AGEs induced the TNFAIP2-TNT system. In diabetic mice, tnfaip2deletion exacerbated albuminuria, renal function loss, podocyte injury, and mesangial expansion. Moreover, blockade of the autophagic flux due to lysosomal dysfunction was observed in diabetes-injured podocytes both in vitroand in vivoand exacerbated by tnfaip2deletion. TNTs allowed autophagosome and lysosome exchange between podocytes, thereby ameliorating AGE-induced lysosomal dysfunction and apoptosis. This protective effect was abolished by tnfaip2deletion, TNT inhibition, and donor cell lysosome damage. By contrast, Tnfaip2overexpression enhanced TNT-mediated transfer and prevented AGE-induced autophagy and lysosome dysfunction and apoptosis. In conclusion, TNFAIP2 plays an important protective role in podocytes in the context of DN by allowing TNT-mediated autophagosome and lysosome exchange and may represent a novel druggable target.Abbreviations:AGEs: advanced glycation end products; AKT1: AKT serine/threonine kinase 1; AO: acridine orange; ALs: autolysosomes; APs: autophagosomes; BM: bone marrow; BSA: bovine serum albumin; CTSD: cathepsin D; DIC: differential interference contrast; DN: diabetic nephropathy; FSGS: focal segmental glomerulosclerosis; HG: high glucose; KO: knockout; LAMP1: lysosomal-associated membrane protein 1; LMP: lysosomal membrane permeabilization; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; PI3K: phosphoinositide 3-kinase; STZ: streptozotocin; TNF: tumor necrosis factor; TNFAIP2: tumor necrosis factor, alpha-induced protein 2; TNTs: tunneling nanotubes; WT: wild type.
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- 2023
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5. Solid phase extraction with rotating cigarette filter for determination of bisphenol A in source and drinking water: computational and analytical studies
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Saini, Shivender Singh, Copello, Guillermo J., and Martini, M. Florencia
- Abstract
Graphical abstract:
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- 2023
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6. Revisión sistemática y metaanálisis sobre CK20, CD44, Ki67 y p53 como marcadores inmunohistoquímicos en el carcinoma in situ vesical
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Straccia, P., Fiorentino, V., Martini, M., and Pierconti, F.
- Abstract
La displasia urotelial y el carcinoma in situ (CIS) están relacionados con la recurrencia y la progresión del carcinoma urotelial. Diferenciar el CIS y la displasia de la atipia reactiva suele ser difícil sobre la base de las características histológicas. La integración de los hallazgos histológicos con la inmunohistoquímica se utiliza en la práctica habitual para realizar el diagnóstico del CIS y, para ello, se utilizan los marcadores inmunohistoquímicos CK20, CD44, Ki67 y p53 como complemento al estudio histológico.
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- 2022
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7. CCT‘S CRYSTAL BALL: PREDICTING CARDIOVASCULAR RISK IN AORTIC VALVE STENOSIS PATIENTS UNDERGOING VALVE REPLACEMENT
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Savo, M, Pergola, V, Bariani, R, De Amicis, M, Cozza, E, Amato, F, Martini, M, Sonego, P, De Conti, G, Rigato, L, Mattesi, G, Bauce, B, Illiceto, S, and Motta, R
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- 2024
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8. Eccipienti cosmetici o ingredienti tecnologici
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Martini, M.-C.
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I prodotti cosmetici sono costituiti per il 20% da prodotti totalmente anidri e per circa il 20% da prodotti totalmente acquosi; il resto è rappresentato da prodotti emulsionati. Gli eccipienti si dividono quindi in due gruppi: lipofili e idrofili. Gli eccipienti lipofili sono idrocarburi, siliconi, trigliceridi, cere, alcoli grassi, acidi grassi, esteri grassi e gelificanti lipofili. Gli eccipienti idrofili sono acqua, umettanti e gelificanti idrofili. A questo insieme si possono aggiungere le polveri organiche e inorganiche, insolubili in entrambe le fasi, come gli ossidi inorganici, poi la silice e i silicati come talco e caolino, polveri di poliammide e amido. Gli additivi come coloranti e conservanti non sono inclusi in questo articolo e neppure i tensioattivi.
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- 2022
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9. Cct's Crystal Ball: Predicting Cardiovascular Risk In Aortic Valve Stenosis Patients Undergoing Valve Replacement.
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Pergola, V., Savo, M., Bariani, R., De Amicis, M., Cozza, E., Amato, F., Martini, M., Sonego, P., De Conti, G., Mattesi, G., Rigato, I., Bauce, B., Illiceto, S., and Motta, R.
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- 2024
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10. Differential Stability of Aurein 1.2 Pores in Model Membranes of Two Probiotic Strains.
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Balatti, Galo E., Domene, Carmen, Martini, M. Florencia, and Pickholz, Monica
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- 2020
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11. When a mimicker wears strange faces: description of an osteogenic melanoma arising within an ovarian teratoma with focus on its late peritoneal relapse.
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ANGELICO, G., SANTORO, A., INZANI, F., MARTINI, M., D'ALESSANDRIS, N., SPADOLA, S., VALENTE, M., ARCIUOLO, D., SFREGOLA, S., MULE, A., SCAMBIA, G., and ZANNONI, G. F.
- Abstract
Secondary malignancies arising within mature teratomas are a rare event, originating from malignant transformation of the tissues derived from one of the three germ cell layers. Osteogenic melanoma is exceedingly rare histologic variant of malignant melanoma, in which the melanoma is associated to an osteogenic sarcoma component. To the best of our knowledge, first case of osteogenic melanoma arising within mature ovarian teratoma in a 30-year-old woman without evidence of a primary cutaneous or visceral melanoma. The present case showed an unusual morphological and immunohistochemical pattern and was incorrectly diagnosed as undifferentiated carcinoma. After a 15 years follow-up period, the patient presented a peritoneal recurrence histologically constituted by epithelioid cells with prominent osteoid formation and with immunohistochemical expression of melanocytic markers (S100, HMB-45). Heterozygote Mutation V600E/E complex has been detected in the BRAF exon 15 sequence. The case was then interpreted as osteogenic melanoma. The present case contributes to widen the spectrum of neoplasms derived from malignant transformation of ovarian teratomas and provides also new insights about the clinical behavior of osteogenic melanoma when arising outside its usual anatomical location [ABSTRACT FROM AUTHOR]
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- 2020
12. Prodotti per il trucco del viso
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Martini, M.-C.
- Abstract
I prodotti per il trucco del viso includono rossetti, fondotinta, ciprie, fard e prodotti per il trucco degli occhi, eyeliner, ombretti, mascara, matite e kajal. Tutti questi prodotti contengono grandi quantità di coloranti di origine naturale e sintetica sotto forma insolubile di pigmenti o lacche. La natura, la legislazione e il nome dei coloranti sono dettagliati, così come la composizione dei vari prodotti che li contengono. Vengono discussi la tolleranza, la conservazione e gli eventuali controlli di ogni tipo di prodotto. Infine, il mercato francese di tutti i prodotti per il trucco è paragonato al mercato cosmetico globale.
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- 2021
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13. Differential Stability of Aurein 1.2 Pores in Model Membranes of Two Probiotic Strains
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Balatti, Galo E., Domene, Carmen, Martini, M. Florencia, and Pickholz, Monica
- Abstract
Aurein 1.2 is an antimicrobial peptide from the skin secretion of an Australian frog. In the previous experimental work, we reported a differential action of aurein 1.2 on two probiotic strains Lactobacillus delbrueckiisubsp. bulgaricus(CIDCA 331) and Lactobacillus delbrueckiisubsp. lactis(CIDCA 133). The differences found were attributed to the bilayer compositions. Cell cultures and CIDCA 331-derived liposomes showed higher susceptibility than the ones derived from the CIDCA 133 strain, leading to content leakage and structural disruption. Here, we used molecular dynamics simulations to explore these systems at the atomistic level. We hypothesize that if the antimicrobial peptides organized themselves to form a pore, it will be more stable in membranes that emulate the CIDCA 331 strain than in those of the CIDCA 133 strain. To test this hypothesis, we simulated preassembled aurein 1.2 pores embedded into bilayer models that emulate the two probiotic strains. It was found that the general behavior of the systems depends on the composition of the membrane rather than the preassemble system characteristics. Overall, it was observed that aurein 1.2 pores are more stable in the CIDCA 331 model membranes. This fact coincides with the high susceptibility of this strain against antimicrobial peptide. In contrast, in the case of the CIDCA 133 model membranes, peptides migrate to the water–lipid interphase, the pore shrinks, and the transport of water through the pore is reduced. The tendency of glycolipids to make hydrogen bonds with peptides destabilizes the pore structures. This feature is observed to a lesser extent in CIDCA 331 due to the presence of anionic lipids. Glycolipid transverse diffusion (flip-flop) between monolayers occurs in the pore surface region in all the cases considered. These findings expand our understanding of the antimicrobial peptide resistance properties of probiotic strains.
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- 2020
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14. Integrated Dating of the Construction and Restoration of the Modena Cathedral Vaults (Northern Italy): Preliminary Results
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Tirelli, G, Lugli, S, Galli, A, Hajdas, I, Lindroos, A, Martini, M, Maspero, F, Olsen, J, Ringbom, Å, Sibilia, E, Caroselli, M, Silvestri, E, Panzeri, L, Toffolo, Michael, Boaretto, Elisabetta, Chapoulie, Rémy, and Guibert, Pierre
- Abstract
ABSTRACTAfter the last damaging earthquake in 2012, an anti-seismic reinforcement project of the cathedral of Modena was designed giving us the opportunity to investigate and date the building materials. Radiocarbon (14C), optically stimulated luminescence (OSL), and thermoluminescence (TL) dating techniques were performed on the vaults with the aim to (1) clarify the construction timing, (2) define the history of the restorations, and (3) explore the possible correlation of the main restoration works to the earthquake chronology deduced from the historic catalog. Preliminary results show that medieval older bricks were reused for most of the original construction. Only lime and non-gypsum mortar was used for the original construction in the 15th century and for later repair of damage caused by earthquakes in the 16th and 17th centuries. Gypsum mortar was used for later repair in the 18th century. The results show much stronger damage due to earthquakes than previously thought.
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- 2020
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15. Déodorants et antitranspirants
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Martini, M.-C.
- Abstract
Les termes déodorants et antitranspirants sont très souvent confondus alors que les mécanismes d’action des uns et des autres ainsi que les substances actives employées sont totalement différents. Il est certain que les antitranspirants sont obligatoirement déodorants par manque de substrat à décomposer. Ils représentent cependant un groupe de produits bien particulier qui génère des problèmes spécifiques par suite de la présence d’aluminium chlorhydrate ou ACH (Al2(OH)5Cl, 2 H2O), d’aluminium sesquichlorhydrate ou de complexe d’aluminium-zirconium entraînant après hydrolyse une acidification intense de la peau, d’où l’importance des émollients et des régulateurs de pH dans les formulations. Par ailleurs, l’aluminium par voie systémique est soupçonné d’être génotoxique et de promouvoir l’apparition de cancers du sein, engendrant ainsi de nombreuses controverses scientifiques. Or, son éventuelle toxicité par voie topique est liée à sa capacité de pénétration cutanée encore mal connue mais estimée très faible, ce qui peut rassurer sur son utilisation dans les produits cosmétiques. Son implication dans la maladie d’Alzheimer n’a pas été prouvée. En revanche, les sels de zirconium sont considérés comme toxiques et partiellement réglementés en Europe. Les problèmes posés par les déodorants sont ceux de la présence d’antiseptiques (triclosan, acide usnique) pouvant induire des résistances bactériennes mais plus sûrement la présence de dermatites axillaires dues au potentiel allergène des constituants de parfums et des huiles essentielles (isoeugénol, citronellal, lyral, aldéhyde cinnamique, etc.).
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- 2020
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16. Mortar OSL and brick TL dating: The case study of the UNESCO world heritage site of Modena.
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Panzeri, L., Caroselli, M., Galli, A., Lugli, S., Martini, M., and Sibilia, E.
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QUARTZ ,BAYESIAN analysis ,BLEACHING (Chemistry) ,CHRONOLOGY - Abstract
Abstract In this study, TL and OSL dating were applied respectively to bricks and mortars taken from a few key structures of the UNESCO World Heritage Site of Modena (northern Italy). The samples came from the Cathedral and the Ghirlandina Tower, built between the end of the XII century and the first half of the XIV century AD. TL dating of bricks showed that we were dealing with the well-known phenomenon of re-use of ancient Roman bricks. However, it was also possible to discover and date quite precisely a previously unknown renovation phase in the Cathedral apse area (XVI century). Regarding the OSL mortar dating, both Multi-Grain and Single Grain techniques were applied on quartz grains, possibly well bleached during mortar preparation. OSL gave good results for one sample from the Cathedral and three from the Ghirlandina Tower. The other gave ages much older than expected, indicating the possible uncompleted bleaching of the quartz grains as the main problem of this dating application. Finally, the application of the Bayesian statistical approach, reducing the error associated with the data, supported a new building chronology, in particular for the Ghirlandina Tower. Highlights • TL bricks and OSL mortars dating. • Evidence of reuse of Roman bricks. • Uncompleted bleaching of the OSL signal of mortar. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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17. Applying the "pre-bleached with blue LEDs" protocol to date Umayyad mosaic tesserae by thermoluminescence.
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Galli, A., Caccia, M., Martini, M., Panzeri, L., Maspero, F., Fiorentino, S., Vandini, M., and Sibilia, E.
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CALIPHS ,TESSERAE ,THERMOLUMINESCENCE ,RADIATION dosimetry ,GLASS - Abstract
Abstract This paper deals with a Thermoluminescence (TL) study of ancient mosaic tesserae from the qasr (winter residence) of Khirbat al-Mafjar, amazing palace of the Islamic caliphs located in the plain of Jericho. In literature, works dealing with the dating of mosaic tesserae usually rely on the dosimetric properties of the microcrystalline inclusions in the silica matrix rather than on the matrix itself. On the other hand, in the last decades, commercial glasses have been demonstrated to be suitable for retrospective accidental dosimetry. In this work, we applied a protocol widely used for the mobile phones' glasses, the so-called "pre-bleached with blue LEDs" protocol, to evaluate the archeological dose absorbed by some Khirbat al-Mafjar tesserae in order to confirm their dating based on archaeological evidence. As for commercial glasses, the TL signal from ancient tesserae presents anomalous fading and it is light sensitive. The experimental protocol circumvents these problems isolating the thermally more stable TL signal with an optical pretreatment and allowing the determination of a fading curve for each analyzed sample. Using an integrative approach, we estimated the fading correction for these tesserae and we retrieved their ages. The results are partially in agreement with those hypothesized on historical ground and show good potentialities for the dating of amorphous archaeological glassy materials. Highlights • TL dating of ancient glass mosaic tesserae. • Specific experimental protocol studied for the mobile phones' display glasses. • Empirical correction for anomalous fading. [ABSTRACT FROM AUTHOR]
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- 2019
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18. Techno-economic analysis of a natural gas combined cycle integrated with a Ca-Cu looping process for low CO2 emission power production.
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Martínez, I., Martini, M., Riva, L., Gallucci, F., Van Sint Annaland, M., and Romano, M.C.
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NATURAL gas ,ELECTRIC power plants ,GAS analysis ,FIXED bed reactors ,CAPITAL costs - Abstract
Highlights • 1D simulation of the Ca-Cu fixed bed reactors and process integration study. • Economic optimization of the Ca-Cu reactors size and pressure drops through heat exchangers. • Net efficiency 0.5% points higher than benchmark with 89.1% of CO 2 capture efficiency. • ˜5% lower cost of CO 2 avoided cost than the benchmark. Abstract A techno-economic analysis of a natural gas combined cycle integrated with a pre-combustion CO 2 capture process based on the Ca-Cu process has been carried out. An extensive calculation of the balances of the entire power plant has been done, including the results obtained from a 1-D pseudo homogeneous model for the fixed bed reactors that compose the Ca-Cu process. Moreover, a methodology developed by the authors is here presented for calculating the cost of the electricity produced and of the CO 2 avoided. This methodology has been used to perform the economic analysis of the Ca-Cu based power plant and to optimize the size of the Ca-Cu reactors and the pressure drop in critical heat exchangers. An electricity cost of 82.6 €/MWh has been obtained for the Ca-Cu based power plant, which is 2.2 €/MWh below the benchmark power plant based on an Auto Thermal Reformer with an MDEA absorption process for CO 2 capture. The improved performance of the Ca-Cu based power plant in terms of electric efficiency and reduced capital cost expenditure is the reason for the reduced electricity costs. Moreover, a lower cost of CO 2 avoided is also obtained for the Ca-Cu plant with respect to the benchmark (80.75 €/t CO2 vs. 85.38 €/t CO2), which features 89% of CO 2 capture efficiency. [ABSTRACT FROM AUTHOR]
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- 2019
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19. N-haloacetyl phenothiazines and derivatives: Preparation, characterization and structure-activity relationship for antifungal activity.
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Sarmiento, Gabriela P., Martini, M. Florencia, Vitale, Roxana G., Fabian, Lucas E., Afeltra, Javier, Vega, Daniel, Moltrasio, Graciela Y., and Moglioni, Albertina G.
- Abstract
Graphical abstract The antifungal activity evaluation of all N -acetyl phenothiazines prepared and characterized was performed in vitro against 163 isolated human pathogenic yeasts and filamentous fungi. The most promising compounds were those bearing one chlorine or bromine atom attached to the N -acetyl group. These compounds were as active as 5-fluorocitosine or fluconazole, currently in clinical use. A qualitative and quantitative structure-activity relationship for antifungal activity was attempted to be established. Abstract A serie of N -acetyl phenothiazines and related compounds was synthesized by means of the acetylation reaction of the corresponding phenothiazine with the appropriate reagent using microwave irradiation. Structural elucidation of these heterocyclic derivatives was done using
1 H,13 C NMR spectra. The equilibra between conformationals enantiomers were studied as a possible atropisomerism case. The single crystal X-ray diffraction of some derivatives was also recorded and the presence of enantiomers could be confirmed. The antifungal activity evaluation of all N -acetyl phenothiazines prepared by us in this and in a previous work, was performed in vitro against 163 isolated human pathogenic yeasts and filamentous fungi, including: Cryptococcus neoformans, Candida albicans, Candida non-albicans, Aspergillus and Acremonium-Fusarium. The most promising compounds were those bearing one chlorine or bromine atom attached to the N -acetyl group. These compounds were as active as 5-fluorocitosine (5-FC) or fluconazole (FCZ), currently in clinical use. A structure-activity relationship (SAR) and a quantitative structure-activity relationship (QSAR) for antifungal activity of each genus were established. [ABSTRACT FROM AUTHOR]- Published
- 2019
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20. A surveillance system for diseases of companion animals in the Veneto region (Italy).
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Martini, M., Fenati, M., Agosti, M., Cassini, R., Drigo, M., Ferro, N., Guglielmini, C., Masiero, I., Signorini, M., and Busetto, R.
- Published
- 2017
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21. EPR investigation of the role of germanium centers in the production of the 110°C thermoluminescence peak in quartz.
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Vaccaro, G., Panzeri, L., Paleari, S., Martini, M., and Fasoli, M.
- Subjects
QUARTZ ,THERMOLUMINESCENCE dosimetry ,THERMOLUMINESCENCE dating ,ELECTRON paramagnetic resonance ,ACTIVATION energy - Abstract
The identification of the center acting as electron source for the well-known 110 °C thermoluminescence (TL) peak of quartz is of fundamental importance for practical applications in dating and dosimetry. This TL peak was studied in parallel with the electron paramagnetic resonance (EPR) signal of the [GeO 4 ] − center on natural colourless quartz irradiated at room temperature. Immediately after irradiation, the signals of the 110 °C TL peak and of [GeO 4 ] − center decay exponentially in the same way, yielding a lifetime of 50.4 ± 0.9 min at room temperature. Besides, we acquired the isothermal decay curves for the 110 °C TL peak and [GeO 4 ] − center at different temperatures (the samples were held at the selected temperature in the range of 260–308 K). The lifetimes extracted by the isothermal decays were plotted as a function of reciprocal temperature, revealing again the same behavior of the 110 °C TL peak and [GeO 4 ] − center, both characterized by activation energies very close of 0.76 ± 0.07 eV and 0.77 ± 0.07 eV, respectively. All results of the present work clearly show the role of electron source of [GeO 4 ] − center in the emission mechanism of the 110 °C TL peak in quartz. [ABSTRACT FROM AUTHOR]
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- 2017
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22. MISERICORDIA Y JUSTICIA (A PARTIR DE LA BULA MISERICORDIAE VULTUS).
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De Martini, M. A.
- Published
- 2016
23. V-Shaped Molecular Configuration of Wax Esters of Jojoba Oil in a Langmuir Film Model
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Caruso, Benjamín, Martini, M. Florencia, Pickholz, Mónica, and Perillo, María A.
- Abstract
The aim of the present work was to understand the interfacial properties of a complex mixture of wax esters (WEs) obtained from Jojoba oil (JO). Previously, on the basis of molecular area measurements, a hairpin structure was proposed as the hypothetical configuration of WEs, allowing their organization as compressible monolayers at the air–water interface. In the present work, we contributed with further experimental evidence by combining surface pressure (π), surface potential (ΔV), and PM-IRRAS measurements of JO monolayers and molecular dynamic simulations (MD) on a modified JO model. WEs were self-assembled in Langmuir films. Compression isotherms exhibited πlift-offat 100 Å2/molecule mean molecular area (Alift-off) and a collapse point at πc≈ 2.2 mN/m and Ac≈ 77 Å2/molecule. The ΔVprofile reflected two dipolar reorganizations, with one of them at A> Alift-offdue to the release of loosely bound water molecules and another one at Ac< A< Alift-offpossibly due to reorientations of a more tightly bound water population. This was consistent with the maximal SP value that was calculated according to a model that considered two populations of oriented water and was very close to the experimental value. The orientation of the ester group that was assumed in that calculation was coherent with the PM-IRRAS behavior of the carbonyl group with the C═O oriented toward the water and the C–O oriented parallel to the surface and was in accordance with their orientational angles (∼45 and ∼90°, respectively) determined by MD simulations. Taken together, the present results confirm a V shape rather than a hairpin configuration of WEs at the air–water interface.
- Published
- 2018
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24. Recent QCD results from the NA48/2 experiment
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Anzivino, Giuseppina, Anzivino, G., Arcidiacono, R., Baldini, W., Balev, S., Batley, J.R., Behler, M., Bifani, S., Biino, C., Bizzeti, A., Bloch-Devaux, B., Bocquet, G., Cabibbo, N., Calvetti, M., Cartiglia, N., Ceccucci, A., Celeghini, E., Cenci, P., Cerri, C., Cheshkov, C., Chèze, J.B., Clemencic, M., Collazuol, G., Costantini, F., Cotta Ramusino, A., Coward, D., Cundy, D., Dabrowski, A., Dalpiaz, P., Damiani, C., De Beer, M., Derré, J., Dibon, H., DiLella, L., Doble, N., Eppard, K., Falaleev, V., Fantechi, R., Fidecaro, M., Fiorini, L., Fiorini, M., Fonseca Martin, T., Frabetti, P.L., Gatignon, L., Gersabeck, E., Gianoli, A., Giudici, S., Gonidec, A., Goudzovski, E., Goy Lopez, S., Hita-Hochgesand, M., Holder, M., Hristov, P., Iacopini, E., Imbergamo, E., Jeitler, M., Kalmus, G., Kekelidze, V., Kleinknecht, K., Kozhuharov, V., Kubischta, W., Lamanna, G., Lazzeroni, C., Lenti, M., Litov, L., Madigozhin, D., Maier, A., Mannelli, I., Marchetto, F., Marchevski, R., Marel, G., Markytan, M., Marouelli, P., Martini, M., Masetti, L., Mazzucato, E., Michetti, A., Mikulec, I., Misheva, M., Molokanova, N., Monnier, E., Moosbrugger, U., Morales Morales, C., Munday, D.J., Nappi, A., Neuhofer, G., Norton, A., Patel, M., Pepe, M., Peters, A., Petrucci, F., Petrucci, M.C., Peyaud, B., Piccini, M., Pierazzini, G., Polenkevich, I., Potrebenikov, Yu., Raggi, M., Renk, B., Rubin, P., Ruggiero, G., Savrié, M., Scarpa, M., Shieh, M., Shkarovskiy, S., Slater, M.W., Sozzi, M., Stoynev, S., Swallow, E., Szleper, M., Valdata-Nappi, M., Vallage, M., Velasco, M., Veltri, M., Venditti, S., Wache, M., Wahl, H., Walker, A., Wanke, R., Widhalm, L., Winhart, A., Winston, R., Wood, M.D., Wotton, S.A., Zinchenko, A., and Ziolkowski, M.
- Abstract
The NA48/2 experiment collected data in 2003 and 2004 with the main purpose to study direct CP violation in charged kaons decaying in three pions. Thanks to the huge statistics collected, other studies are also possible. In this paper two recent results, in the framework of QCD studies, are reported: the measurement of the K±→ π0e±νForm Factors and the first observation of the rare decay K±→ π±π0e+e−.
- Published
- 2018
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25. Autobronzants et bronzants artificiels
- Author
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Martini, M.-C.
- Abstract
Les autobronzants actuellement sur le marché sont pratiquement tous à base de dihydroxyacétone (DHA) associée ou non à l’érythrulose, à des dérivés de tyrosine, parfois à une naphtoquinone. La coloration obtenue, voisine du bronzage naturel, est due à la combinaison chimique de la DHA avec les acides aminés de la peau selon la réaction de Maillard. Il y a formation de mélanoïdines, pigments polymériques, fixés dans le stratum corneum qui y demeurent jusqu’à desquamation des cornéocytes. Cette coloration est donc semi-permanente, bien tolérée par la peau. La formulation des produits est délicate et leur conservation difficile mais aucune autre substance ne fournit de résultats plus satisfaisants et plus durables.
- Published
- 2017
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26. QUANTITIVE EVALUATION OF DENTIN SIALOPROTEIN (DSP) USING MICROBEADS - A POTENTIAL EARLY MARKER OF ROOT RESORPTION.
- Author
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LOMBARDO, L., CARINCI, F., MARTINI, M., GEMMATI, D., NARDONE, M., and SICILIANI, G.
- Subjects
DENTIN abnormalities ,SIALOGLYCOPROTEINS ,ORTHODONTICS - Abstract
Purpose. This study had the aim of comparing two different methods of analysing dentin sialoprotein (DSP) in the gingival crevicular fluid (GCF): the conventional eLISA approach and a new method involving the use of magnetic micro-beads coated with an antibody specific for DSP prior to eLISA analysis. Materials and methods. GCF was taken from six patients following twelve weeks of orthodontic treatment using paper strips inserted into the mesial and distal sulci of the upper incisors, and analysed using both methods. Results. Statistical analysis of the results using the Mann-Whitney non-parametric test showed that the micro-bead approach conferred more reliability and less variability on the conventional eLISA approach. Furthermore, this method, for the first time, enables the quantification of the DSP in the sample in ng/μl. Conclusions. The innovative micro-bead/eLISA approach proposed provides a reliable means of quantifying the DSP in the GCF. [ABSTRACT FROM AUTHOR]
- Published
- 2016
27. Postpartum pain in relation with Personal Meaning Organization.
- Author
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NARDI, B., MARTINI, M. G., ARIMATEA, E., VERNICE, M., BELLANTUONO, C., FRIZZO, H., NARDI, M., and VINCENZI, R.
- Published
- 2015
28. A 3D morphometric follow-up analysis after frontoorbital advancement in non-syndromic craniosynostosis.
- Author
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Martini, M., Schulz, M., Röhrig, A., Nadal, J., and Messing-Jünger, M.
- Subjects
FOLLOW-up studies (Medicine) ,THREE-dimensional imaging ,MORPHOMETRICS ,CRANIOSYNOSTOSES ,PARAMETER estimation - Abstract
Objective Frontoorbital advancement (FOA) in patients with non-syndromic craniosynostosis mainly addresses the aesthetic and functional correction of the frontoorbital region. To help define the operative strategy and any follow-up assessments after surgical correction, objective parameters describing the critical regions of skull deformity are essential. Based on 3D morphometric analysis, new parameters for the documentation of changes of the frontoorbital bandeau were developed in a prospective study. Methods and materials In a prospective series, 13 children with non-syndromic craniosynostosis (seven metopic, four unilateral coronal, and two bilateral coronal) treated with frontoorbital advancement, underwent detailed morphometric and volumetric evaluation using a 3D light optical scan system (3D-Shape, Erlangen, Germany). Measurements were obtained preoperatively and at 3, 6 and 12 months postoperatively with newly developed parameters generated by cephalometric analysis software (Onyx Ceph, Image Instruments, Chemnitz, Germany). Results In most patients, frontoorbital advancement resulted in stable long-term results without growth inhibition and with normalization or improvement of ongoing skull development. The mean frontal angle was 145° and the frontoparietal angle 137–140°. The cephalic index was normalized or markedly improved. Head circumference and head height increased significantly ( p = 0.001 and p = 0.002, respectively). These changes were confirmed in all postoperative measurements. Conclusion During the 12-month follow-up period all angle parameters proved to be stable and no major impairment of normal skull growth was observed after FOA. The frontoorbital angle is a useful parameter in evaluating long-term outcome. The frontoparietal angle is important for the stability of the frontoparietal region, in which a certain growth inhibition may be observed postoperatively. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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29. Biophysical Analysis to Assess the Interaction of CRAC and CARC Motif Peptides of Alpha Hemolysin of Escherichia coliwith Membranes
- Author
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Cané, Lucía, Guzmán, Fanny, Balatti, Galo, Daza Millone, María Antonieta, Pucci Molineris, Melisa, Maté, Sabina, Martini, M. Florencia, and Herlax, Vanesa
- Abstract
Alpha hemolysin of Escherichia coli(HlyA) is a pore-forming protein, which is a prototype of the “Repeat in Toxins” (RTX) family. It was demonstrated that HlyA–cholesterol interaction facilitates the insertion of the toxin into membranes. Putative cholesterol-binding sites, called cholesterol recognition/amino acid consensus (CRAC), and CARC (analogous to CRAC but with the opposite orientation) were identified in the HlyA sequence. In this context, two peptides were synthesized, one derived from a CARC site from the insertion domain of the toxin (residues 341–353) (PEP 1) and the other one from a CRAC site from the domain between the acylated lysines (residues 639–644) (PEP 2), to study their role in the interaction of HlyA with membranes. The interaction of peptides with membranes of different lipid compositions (pure POPC and POPC/Cho of 4:1 and 2:1 molar ratios) was analyzed by surface plasmon resonance and molecular dynamics simulations. Results demonstrate that both peptides interact preferentially with Cho-containing membranes, although PEP 2 presents a lower KDthan PEP 1. Molecular dynamics simulation results indicate that the insertion and interaction of PEP 2 with Cho-containing membranes are more prominent than those caused by PEP 1. The hemolytic activity of HlyA in the presence of peptides indicates that PEP 2 was the only one that inhibits HlyA activity, interfering in the binding between the toxin and cholesterol.
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- 2023
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30. Investigating the Impact of the Glycolipid Content on Aurein 1.2 Pores in Prokaryotic Model Bilayers: A Coarse-Grain Molecular Dynamics Simulation Study
- Author
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Balatti, G. E., Martini, M. F., and Pickholz, M.
- Abstract
Aurein 1.2 is an antimicrobial peptide (AMP) with known lytic activity against bacterial membranes. Our previous studies revealed a differential action of aurein by both experimental and computational methods. This differential action was over membranes of two related probiotic strains, where the main difference between membranes was the number of glycolipids in the lipid composition. In this work, we aimed to investigate the interaction of aurein 1.2 with model bacterial membranes of varying glycolipid content. To this end, we performed extensive molecular dynamics simulations using the MARTINI coarse-grain force field and differential mixtures of phosphatidylglycerol (PG), phosphatidylethanolamine (PE), and monogalactosylglycerol (MG). We found a correlation between the presence of MG in PG/PE mixtures and the difficulty of aurein to stabilize pore structures, suggesting an AMP-resistance factor encoded in the lipid composition of the membrane. These findings may shed light on a possible mechanism of bacterial resistance to AMPs that is related to the glycolipid content of bacterial membranes.
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- 2023
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31. Profumi
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Parrot, I. and Martini, M.-C.
- Abstract
Che sia diffuso nell’aria che ci circonda, applicato in un cosmetico o presente in prodotti per la cura domestica o la pulizia, il profumo intriga. Il profumo intriga per la sua costruzione, la sua creazione e il segreto intorno alla sua composizione, ma preoccupa il consumatore. Se gli ingredienti naturali anche se ricchi di allergeni rassicurano, gli ingredienti di sintesi sono spesso, e a torto, denigrati. Ritorniamo in questa sede sulla composizione dei profumi, sulla loro legislazione o ancora sulla valutazione della loro tolleranza, ricordando il ruolo degli studi clinici e degli organismi di controllo.
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- 2023
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32. OC.08.3 IMPACT OF ENVIRONMENTAL CHANGES FORCED BY PANDEMIC RESTRICTIVE MEASURES ON THE DEVELOPMENT AND COURSE OF IRRITABLE BOWEL SYNDROME.
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Kayali, S., Furnari, M., Ziola, S., Giuliana, E., Casagrande, E., Djahandideh, A., Marabotto, E., Bodini, G., Martini, M., Marten Canavesio, Y., and Giannini, E.G.
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- 2022
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33. Autoabbronzanti e abbronzanti artificiali
- Author
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Martini, M.-C.
- Abstract
Gli agenti autoabbronzanti attualmente sul mercato sono praticamente tutti basati sul diidrossiacetone (DHA), associato o meno all⬢eritrulosio, a derivati della tirosina e, a volte, a un naftochinone. La colorazione ottenuta, vicina all⬢abbronzatura naturale, è dovuta alla combinazione chimica del DHA con gli aminoacidi della pelle secondo la reazione di Maillard. Vi sarà, dunque, la formazione di melanoidine, pigmenti polimerici, fissati nello strato corneo, che vi rimangono fino alla desquamazione dei corneociti. Questo colore è semipermanente e ben tollerato dalla pelle. La formulazione dei prodotti è delicata e la loro conservazione è difficile, ma nessun⬢altra sostanza fornisce risultati più soddisfacenti e duraturi.
- Published
- 2016
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34. Precision tests of the Standard Model with Kaon decays at CERN
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Lamanna, G., Ambrosino, F., Antonelli, A., Anzivino, G., Arcidiacono, R., Baldini, W., Balev, S., Batley, J.R., Behler, M., Bifani, S., Biino, C., Bizzeti, A., Bloch-Devaux, B., Bocquet, G., Bolotov, V., Bucci, F., Cabibbo, N., Calvetti, M., Cartiglia, N., Ceccucci, A., Cenci, P., Cerri, C., Cheshkov, C., Chèze, J.B., Clemencic, M., Collazuol, G., Costantini, F., Cotta Ramusino, A., Coward, D., Cundy, D., Dabrowski, A., D'Agostini, G., Dalpiaz, P., Damiani, C., Danielsson, H., De Beer, M., Dellacasa, G., Derré, J., Dibon, H., Di Filippo, D., DiLella, L., Doble, N., Duk, V., Engelfried, J., Eppard, K., Falaleev, V., Fantechi, R., Fidecaro, M., Fiorini, L., Fiorini, M., Fonseca Martin, T., Frabetti, P.L., Fucci, A., Gallorini, S., Gatignon, L., Gersabeck, E., Gianoli, A., Giudici, S., Gonidec, A., Goudzovski, E., Goy Lopez, S., Gushchin, E., Hallgren, B., Hita-Hochgesand, M., Holder, M., Hristov, P., Iacopini, E., Imbergamo, E., Jeitler, M., Kalmus, G., Kekelidze, V., Kleinknecht, K., Kozhuharov, V., Kubischta, W., Kurshetsov, V., Lamanna, G., Lazzeroni, C., Lenti, M., Leonardi, E., Litov, L., Madigozhin, D., Maier, A., Mannelli, I., Marchetto, F., Marel, G., Markytan, M., Marouelli, P., Martini, M., Masetti, L., Massarotti, P., Mazzucato, E., Michetti, A., Mikulec, I., Misheva, M., Molokanova, N., Monnier, E., Moosbrugger, U., Morales Morales, C., Moulson, M., Movchan, S., Munday, D.J., Napolitano, M., Nappi, A., Neuhofer, G., Norton, A., Numao, T., Obraztsov, V., Palladino, V., Patel, M., Pepe, M., Peters, A., Petrucci, F., Petrucci, M.C., Peyaud, B., Piandani, R., Piccini, M., Pierazzini, G., Polenkevich, I., Popov, I., Potrebenikov, Yu., Raggi, M., Renk, B., Retière, F., Riedler, P., Romano, A., Rubin, P., Ruggiero, G., Salamon, A., Saracino, G., Savrié, M., Scarpa, M., Semenov, V., Sergi, A., Serra, M., Shieh, M., Shkarovskiy, S., Slater, M.W., Sozzi, M., Spadaro, T., Stoynev, S., Swallow, E., Szleper, M., Valdata-Nappi, M., Valente, P., Vallage, B., Velasco, M., Veltri, M., Venditti, S., Wache, M., Wahl, H., Walker, A., Wanke, R., Widhalm, L., Winhart, A., Winston, R., Wood, M.D., Wotton, S.A., Yushchenko, O., Zinchenko, A., and Ziolkowski, M.
- Abstract
Effects of new physics in flavor could be found both in Flavor Changing Neutral Current (FCNC) processes and in Lepton Flavor Violation (LFV) modes. The former offer the possibility to deeply test the standard model in a clean environment, while the latter are sensitive to contribution from several models beyond the standard model. In the Kaon sector both FCNC and LFV will be investigated in the NA62 experiment. In addition the kaons sector is an ideal place where to look for new particles and tiny effects, in the region of hundreds of MeV/c2. In this paper prospects for exotic searches in NA62 will be presented, together with recent results from NA48/2 and NA62-RK on LFV kaon decays modes.
- Published
- 2016
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35. A Sensitive, Reproducible, and Economic Real-Time Reverse Transcription PCR Detecting Avian Metapneumovirus Subtypes A and B.
- Author
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Franzo, G., Drigo, M., Lupini, C., Catelli, E., Laconi, A., Listorti, V., Bonci, M., Naylor, C. J., Martini, M., and Cecchinato, M.
- Subjects
ASSAYING apparatus ,FIRE assay ,BIRD diseases ,AVIAN medicine ,RNA viruses ,PARAMYXOVIRUSES - Abstract
The article reports on research which was conducted to develop and validate an SYBR Green I–based quantitative reverse transcription (RT)-PCR assay for the detection of the two most prevalent avian metapneumovirus (AMPV) subtypes (i.e., subtypes A and B). After analyzing their assay, researchers concluded that it was a sensitive, specific, and rapid tool, enabling contemporaneous detection, quantification, and discrimination of AMPV subtype A and B.
- Published
- 2014
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36. Profumi
- Author
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Martini, M.-C.
- Abstract
Dopo una breve storia dello sviluppo dell’utilizzo dei profumi nei paesi del contorno mediterraneo dall’antichità fino ai nostri giorni, sono ricordate le diverse metodiche di estrazione dei composti volatili, oli essenziali e assoluti. Si tratta, principalmente, dell’idrodistillazione, delle estrazioni con solventi volatili e non volatili e dell’estrazione meccanica. Vengono spiegate in dettaglio la composizione chimica e tecnologica dei profumi così come la legislazione e la tolleranza di alcune materie prime. Sono citati i principali componenti, in particolare quelli il cui utilizzo o il cui nome non sono particolarmente noti.
- Published
- 2015
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37. Tecnology innovation related to comfort on commercial vehicles.
- Author
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Martini, M. and Ferrero, D.
- Subjects
HUMAN comfort ,ERGONOMICS ,COMMERCIAL vehicles ,MOTOR vehicle drivers ,TECHNOLOGICAL innovations ,PASSENGERS ,SAFETY - Abstract
The article explores the efforts of the vehicle manufacturing company Iveco SpA to bring about comfort improvement in its products for drivers and passengers of commercial vehicles. It focuses on technological innovations and realization of tools to improve the life of drivers and maintain security. It also discusses vibrational comfort, thermal comfort, comfort related to ergonomics and after-treatment systems that improve comfort on vehicles.
- Published
- 2012
38. The Illegal Use of Synthetic Pharmaceuticals in Herbal Formulations: An Overview of Adulteration Practices and Analytical Investigations.
- Author
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de Carvalho, L. M., Moreira, A. P., Martini, M., and Falcão, T.
- Abstract
ABSTRACT: Alternative medicine has historically been very popular in developing countries. In this context, self-medication with herbal formulations has increased in both developing and developed nations in recent years. The adulteration of such formulations violates the laws of many countries because it can lead to unpredictable effects in the human body, either due to the isolated effects of an added pharmaceutical or to its interaction with other substances present in the formulation. The development of methodologies for the screening and quantification of adulterated samples should be of great interest for analytical, clinical, and forensic scientists. This review aims to provide a comprehensive approach to this topic and to discuss adulteration cases related to herbal formulations reported in the literature over the last few decades. Furthermore, a classification of the most commonly found synthetic adulterants that are linked to the active principle of herbal formulations was proposed according to their pharmacological action. The available analytical methodologies for the identification of adulteration practices are presented in a systematic and comprehensive way. [ABSTRACT FROM AUTHOR]
- Published
- 2011
39. Gene expression of oncogenes, antimicrobial peptides, and cytokines in the development of oral leukoplakia.
- Author
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Wenghoefer, M., Pantelis, A., Najafi, T., Deschner, J., Allam, J.P., Novak, N., Reich, R., Martini, M., Bergé, S., Fischer, H.P., Jepsen, S., and Winter, J.
- Abstract
Objective: The aim of this study was to investigate the expression pattern of oncogenes, antimicrobial peptides, and genes involved in inflammation in leukoplakia of the oral cavity compared with healthy gingiva. Study design: Biopsies of healthy gingiva (n = 20) and leukoplakia (n = 20), were obtained during routine surgical procedures. RNA was extracted according to standard protocols. Transcript levels of α-defensin (DEFA) 1/3, DEFA-4, S100-A7, deleted-in-oral-cancer (Doc) 1, interleukin (IL) 1β, IL-6, IL-8, IL-10, tumor necrosis factor (TNF) α, cyclooxygenase (Cox) 2, epidermal growth factor (EGF), keratinocyte growth factor (KGF), transforming growth factor (TGF) β1, TGF-α, collagen-IA1 (Col-1), and tenascin-c were analyzed by real-time reverse-transcription polymerase chain reaction. The proteins encoded by the different genes were visualized by immunostaining. Results: Compared with healthy gingiva (set as 1), there was an increased gene expression of DEFA-4 (179.2-fold), S100-A7 (25.4-fold), EGF (24.8-fold), TGF-β1 (25.2-fold), and tenascin-c (34.3-fold) in oral leukoplakia. The expression of IL-1β and Doc-1 was decreased (0.01-fold and 0.2-fold, respectively). Conclusions: The combination of an increased expression of the antimicrobial peptide DEFA-4, the oncogene S100-A7, EGF, and tenascin-c, and a decreased Doc-1 expression in oral leukoplakia might characterize its potency of malignant transformation. Chronic inflammation seems not to be involved in the development of this lesion. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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40. Continuity relief in pediatric physiotherapy: model transition support hospital -- territory.
- Author
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Gallino F, Guenza MC, and Martini M
- Abstract
Copyright of Scienza Riabilitativa is the property of Associazione Italiana Fisioterapisti and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2010
41. Polarization Analysis in the Discrete Wavelet Domain: An Application to Volcano Seismology.
- Author
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D'Auria, L., Giudicepietro, F., Martini, M., Orazi, M., Peluso, R., and Scarpato, G.
- Subjects
WAVELETS (Mathematics) ,POLARIZATION interferometers ,SEISMIC prospecting ,ALGORITHMS ,ORTHOGONALIZATION - Abstract
We propose a method for analyzing the polarization of three-component digital recordings using the discrete wavelet transform (DWT). This method allows for the automatic detection and separation of seismic phases that have a coherent linear or elliptical polarization. It can be correctly used in the analysis of seismic signals relating to volcanic activity because they arise from a complex wave field that consists of near-field and far-field components that have frequency-dependent polarization. First, the analytic extension of the signal is decomposed using DWT, then each single component is used to determine a local complex polarization vector in the timescale domain. This analysis reveals the presence of seismic phases with coherent polarization over a range of DWT scales and finite temporal intervals. Using the orthogonality property of the DWT, it is possible to isolate a single coherent component, reconstructing it in the time domain and computing the full polarization tensor. This procedure can be fully automated, introducing a quantitative definition of wavelet polarization coherence on the DWT dyadic grid. A recursive algorithm (called POLWAV) starts from the wavelet coefficient with the highest modulus, and then selects all of the neighbors that show coherence with it above a given threshold. We show how the POLWAV algorithm can be used for separating wave-field components and for detecting coherent seismic phases on continuous recordings. Example applications to actual seismic recordings at Stromboli Volcano (Tyrrhenian Sea) are presented. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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42. Pain assessment in non-communicative patients: the Italian version of the Non-Communicative Patient's Pain Assessment Instrument (NOPPAIN)
- Author
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Ferrari R, Martini M, Mondini S, Novello C, Palomba D, Scacco C, Toffolon M, Valerio G, Vescovo G, and Visentin M
- Abstract
Background and aims: Although pain in the elderly is a common and important problem, it is frequently underestimated and undertreated. Pain assessment in elderly people is often more difficult than in the general population, because of the occurrence of dementia and other cognitive impairments that may compromise the ability to communicate the presence and the intensity of pain to hospital staff. Recently, several observational tools have been developed in order to assess pain behaviors in non-communicative patients. The aim of the present study was to verify if the Italian version of the Non-Communicative Patient's Pain Assessment Instrument (NOPPAIN) could be used in a hospital setting. Methods: Sixty severely demented patients (MMSE = 12, language test score =3) and 42 cognitively were selected on the basis of their cognitive status and language skills. NOPPAIN forms were filled in at the same time by two nursing staff members after patients' daily care activities; behavioral indicators of the affective state and communicative patients' reports of pain were also collected. Results: Significant interrater agreement was found in the subscores of the four main sections of the NOPPAIN and also in the total score. In addition, in cognitively intact patients there was a moderate (about 0.50) but significant correlation between NOPPAIN ratings and pain self-reports. A positive correlation between pain scores and negative affective state scores was also found, especially in cognitively impaired patients. Conclusions: The preliminary data of the present study support the reliability and validity of the Italian version of the NOP-PAIN, which appears to be an easy-to-use tool in the assessment of pain in hospitalized non-communicative patients. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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43. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer.
- Author
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Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, De Dosso S, Mazzucchelli L, Frattini M, Siena S, Bardelli A, Di Nicolantonio, Federica, Martini, Miriam, Molinari, Francesca, Sartore-Bianchi, Andrea, Arena, Sabrina, Saletti, Piercarlo, De Dosso, Sara, Mazzucchelli, Luca, and Frattini, Milo
- Published
- 2008
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44. Unsupervised Neural Analysis of Very-Long-Period Events at Stromboli Volcano Using the Self-Organizing Maps.
- Author
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Esposito, A. M., Giudicepietro, F., D'Auria, L., Scarpetta, S., Martini, M. G., Coltelli, M., and Marinaro, M.
- Subjects
SELF-organizing maps ,ARTIFICIAL neural networks ,EXPLOSIVE volcanic eruptions ,VOLCANIC eruptions ,VOLCANOES - Abstract
We have implemented a method based on an unsupervised neural network to cluster the waveforms of very-long-period (VLP) events associated with explosive activity at the Stromboli volcano (southern Italy). Stromboli has several active vents in the summit area producing together more than 200 explosions/day. We applied this method to investigate the relationship between each vent and its associated VLP explosive waveform. We selected 147 VLP events recorded between November and December 2005, when digital infrared camera recordings were available. From a visual inspection of the infrared camera images, we classified the VLPs on the basis of which vent produced each explosion. We then applied the self-organizing map (SOM), an unsupervised neural technique widely applied in data exploratory analysis, to cluster the VLPs on the basis of their waveform similarity. Our analysis demonstrates that the most recurrent VLP waveforms are usually generated by the same vent. Some exceptions occurred, however, in which different waveforms are associated with the same vent, as well as different vents generating similar waveforms. This suggests that the geometry of the upper conduit-vent system plays a role in shaping the recurring VLP events, whereas occasional modest changes in the source process dynamics produce the observed exceptions. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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45. Decreased gene expression of human β-defensin-1 in the development of squamous cell carcinoma of the oral cavity.
- Author
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Wenghoefer, M., Pantelis, A., Dommisch, H., Reich, R., Martini, M., Allam, J.-P., Novak, N., Bergé, S., Jepsen, S., and Winter, J.
- Subjects
GENE expression ,INTERLEUKIN-1 ,TUMOR necrosis factors ,POLYMERASE chain reaction - Abstract
Abstract: The aim of this study was to investigate the gene expression of human β-defensin-1, -2, -3 (hBD-1, -2, -3), interleukin-1β, tumour necrosis factor-α and cyclooxygenase-2 in oral squamous cell carcinoma (OSCC) compared to benign and premalignant lesions as well as healthy controls. Biopsies of healthy gingiva (n=5), irritation fibroma (n=5), leukoplakia (n=5) and OSCC (n=5) were obtained during routine surgical procedures. RNA was extracted according to standard protocols and transcripts of hBD-1, -2, -3, interleukin-1β, tumour necrosis factor-α and cyclooxygenase-2 were analysed by real-time polymerase chain reaction. The expression of hBD-1 was reduced in all lesions (5-fold in irritation fibroma and 2.5-fold in leukoplakia), but most significantly (50-fold) in OSCC. hBD-1 appears to play a role in the development of OSCC. The loss of its function might contribute to the malignant progression of these tumours. [Copyright &y& Elsevier]
- Published
- 2008
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46. Trans-sinusoidal maxillary distraction in three cleft patients.
- Author
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Wenghoefer, M., Martini, M., Nadjmi, N., Schutyser, F., Jagtman, A.K., and Bergé, S.
- Subjects
CLEFT palate ,PALATE abnormalities ,OSTEOTOMY ,BONE surgery - Abstract
Abstract: The trans-sinusoidal maxillary distractor (TS-MD) was used to achieve maxillary advancement in three patients with repaired cleft lip and palate. After preoperative computer-aided planning of the distraction vectors, each TS-MD was bent on a stereolithographic model of the maxilla of the patient. The devices were intraoperatively positioned using a methyl-methacrylate template. After standard Le Fort I osteotomy the devices were intraorally activated. After distraction the devices remained in situ for 3 months as rigid internal fixation of the maxilla. All patients were successfully distracted according to protocol. Maxillary advancement was 12, 8 and 11mm. In two patients, additional maxillary widening of 6 and 8mm was achieved by choosing divergent distraction vectors. After distraction a clockwise rotation of the maxilla was observed in two patients. There was no relapse during the 3 months of consolidation and 12-month follow-up. The TS-MD allows not only distraction but also rigid internal fixation after distraction. It was easy to apply but difficult to remove. Owing to preoperative 3D planning of the distraction vectors, the results were predictable, but clockwise rotation of the maxilla during distraction should be considered in planning. The distractor did not interfere with function or social activities during distraction and retention periods. After removal it left no extraoral scars. [Copyright &y& Elsevier]
- Published
- 2006
- Full Text
- View/download PDF
47. Automatic Discrimination among Landslide, Explosion-Quake, and Microtremor Seismic Signals at Stromboli Volcano Using Neural Networks.
- Author
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Esposito, A. M., Giudicepietro, F., Scarpetta, S., D'Auria, L., Marinaro, M., and Martini, M.
- Subjects
LANDSLIDES ,EARTHQUAKE zones ,TSUNAMIS ,VOLCANOES ,ARTIFICIAL neural networks - Abstract
In this article we report on the implementation of an automatic system for discriminating landslide seismic signals on Stromboli island (southern Italy). This is a critical point for monitoring the evolution of this volcanic island, where at the end of 2002 a violent tsunami occurred, triggered by a big landslide. We have devised a supervised neural system to discriminate among landslide, explosion-quake, and volcanic microtremor signals. We first preprocess the data to obtain a compact representation of the seismic records. Both spectral features and amplitude-versus-time information have been extracted from the data to characterize the different types of events. As a second step, we have set up a supervised classification system, trained using a subset of data (the training set) and tested on another data set (the test set) not used during the training stage. The automatic system that we have realized is able to correctly classify 99% of the events in the test set for both explosion-quake/ landslide and explosion-quake/microtremor couples of classes, 96% for landslide/ microtremor discrimination, and 97% for three-class discrimination (landslides/ explosion-quakes/microtremor). Finally, to determine the intrinsic structure of the data and to test the efficiency of our parametrization strategy, we have analyzed the preprocessed data using an unsupervised neural method. We apply this method to the entire dataset composed of landslide, microtremor, and explosion-quake signals. The unsupervised method is able to distinguish three clusters corresponding to the three classes of signals classified by the analysts, demonstrating that the parametrization technique characterizes the different classes of data appropriately. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
48. Immunohistochemical Study of STAT3 Expression in Feline Injection-site Fibrosarcomas.
- Author
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Petterino, C., Martano, M., Cascio, P., Cerruti, F., Martini, M., Morello, E., Bruno, R., Castagnaro, M., and Buracco, Paolo
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IMMUNOREGULATION ,CELLULAR immunity ,PREVENTIVE medicine ,TUMORS - Abstract
Summary: STAT3 (signal transducer and activator of transcription 3) is a cytoplasmic transcription factor that plays a role in the G1 to S phase cell-cycle transition and is induced by cytokines and growth factors. In the present study, the relation between histological grade and anti-STAT3 immunoreactivity was evaluated in 39 feline injection-site sarcomas treated surgically, 24 of the cats having received preoperative treatment with doxorubicin. Anti-STAT3 immunoreactivity was significantly lower in cases receiving preoperative doxorubicin, specifically with regard to nuclear localization. Moreover, STAT3 expression (intranuclear) was significantly correlated with mitotic activity in the animals that did not receive doxorubicin (P=0.019), and with differentiation score (P=0.009). STAT3 expression was correlated with the histological grade in both doxorubicin-treated and -untreated cats; in the treated cats, however, this correlation applied only to cytoplasmic STAT3 (P=0.018). Doxorubicin treatment induced a significant decrease in STAT3 expression (nuclear, P<0.0001; cytoplasmic, P=0.033) as compared with cases treated by surgery alone. These findings support existing evidence from human and experimental pathology on the potential role of STAT3 in oncogenesis and tumour progression. [Copyright &y& Elsevier]
- Published
- 2006
- Full Text
- View/download PDF
49. Automatic Classification of Seismic Signals at Mt. Vesuvius Volcano, Italy, Using Neural Networks.
- Author
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Scarpetta, S., Giudicepietro, F., Ezin, E. C., Petrosino, S., Del Pezzo, E., Martini, M., and Marinaro, M.
- Subjects
AUTOMATIC classification ,SEISMIC prospecting ,GEOPHYSICAL prospecting ,EARTHQUAKES ,VOLCANOES - Abstract
We present a new strategy for reliable automatic classification of local seismic signals and volcano-tectonic earthquakes (VT). The method is based on a supervised neural network in which a new approach for feature extraction from short period seismic signals is applied. To reduce the number of records required for the analysis we set up a specialized neural classifier, able to distinguish two classes of signals, for each of the selected stations. The neural network architecture is a multi-layer perceptron (MLP) with a single hidden layer. Spectral features of the signals and the parameterized attributes of their waveform have been used as input for this network. Feature extraction is done by using both the linear predictor coding technique for computing the spectrograms, and a function of the amplitude for characterizing waveforms. Compared to strategies that use only spectral signatures, the inclusion of properly normalized amplitude features improves the performance of the classifiers, and allows the network to better generalize. To train the MLP network we compared the performance of the quasi-Newton algorithm with the scaled conjugate gradient method. We found that the scaled conjugate gradient approach is the faster of the two, with quite equally good performance. Our method was tested on a dataset recorded by four selected stations of the Mt. Vesuvius monitoring network, for the discrimination of low magnitude VT events and transient signals caused by either artificial (quarry blasts, underwater explosions) and natural (thunder) sources. In this test application we obtained 100% correct classification for one of the possible pairs of signal types (VT versus quarry blasts). Because this method was developed independently of this particular discrimination task, it can be applied to a broad range of other applications. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
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50. P392 A MULTIMODALITY IMAGING DIAGNOSIS OF A CHALLENGING CASE OF CONCOMITANT GROUP 1 PULMONARY HYPERTENSION AND PARADOXICALLY LOW–FLOW, LOW–GRADIENT AORTIC STENOSIS
- Author
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Martini, M, Zupa, F, Mancuso, D, Baritussio, A, Famoso, G, Perazzolo Marra, M, Iliceto, S, and Rigato, I
- Published
- 2022
- Full Text
- View/download PDF
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