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This article proposes a capacitor parameter estimation method based on wavelet transform and convolution neural network (CNN). By fully utilizing wavelet transforms and the inherently nonideal properties of bandpass filters, the low-frequency and midfrequency band features contained in capacitor voltages are extracted with high resolution. Leveraging these features, a subsequent CNN network simultaneously estimates two crucial aging indicators of capacitors, i.e., capacitance and equivalent series resistance (ESR). While most existing methods can only identify either capacitance or ESR, the proposed method stands out by addressing both. The integration of two different frequency features enables the proposed method to exhibit broader applicability across different modulation schemes and control strategies, and is less sensitive to load conditions and sampling frequency. Experiment results based on a modular multilevel converter case study prove the effectiveness of the proposed method.

The development of lithium metal batteries (LMBs) is severely hindered owing to the limited temperature window of the electrolyte, which renders uncontrolled side reactions, unstable electrolyte/electrode interface (EEI) formation, and sluggish desolvation kinetics for wide temperature operation condition. Herein, we developed an all-fluorinated electrolyte composed of lithium bis(trifluoromethane sulfonyl)imide, hexafluorobenzene (HFB), and fluoroethylene carbonate, which effectively regulates solvation structure toward a wide temperature of 160 °C (−50 to 110 °C). The introduction of thermostable HFB induces the generation of EEI with a high LiF ratio of 93%, which results in an inhibited side reaction and gas generation on EEI and enhanced interfacial ion transfer at extreme temperatures. Therefore, an unparalleled capacity retention of 88.3% after 400 cycles at 90 °C and an improved cycling performance at −50 °C can be achieved. Meanwhile, the practical 1.3 Ah-level pouch cell delivers high energy density of 307.13 Wh kg–1at 60 °C and 277.99 Wh kg–1at −30 °C after 50 cycles under lean E/C ratio of 2.7 g/Ah and low N/P ratio of 1.2. This work not only offers a viable strategy for wide-temperature-range electrolyte design but also promotes the practicalization of LMBs.

The immune checkpoint blockade represents a pivotal strategy for tumor immunotherapy. At present, various programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) monoclonal antibodies have been successfully applied to tumor treatment. Additionally, numerous small molecule inhibitors of the PD-1/PD-L1 interaction have also been developed, with some advancing into clinical trials. Here, a novel PD-L1 proteolysis-targeting chimera (PROTAC) library was designed and synthesized utilizing the PD-L1 inhibitor BMS202and the E3 ligand PGas foundational components. Among these, we identified a highly potent molecule PA8for PD-L1 degradation in 4T1 cells (DC50= 0.609 μM). Significantly, compound PA8potentially inhibits 4T1 cell growth both in vitroand in vivo. Further mechanistic studies revealed that PA8effectively promoted the immune activation of model mice. Thus, these results suggest that PA8could be a novel strategy for cancer immunotherapy in the 4T1 tumor model. Although PA8exhibits weaker degradation activity in some human cancer cells, it still provides a certain basis for further research on PD-L1 PROTAC.

Advancements in anticancer strategies spotlight proteolysis targeting chimera (PROTAC) technology, yet it is hindered by poor water solubility and bioavailability. This study introduces a novel amphiphilic PROTAC, B1-PEG, synthesized through PEGylation of an optimized PROTAC molecule, B1, to enhance its properties. B1-PEGis engineered to self-organize into micelles in water and releases its active form in response to the tumor-specific high GSH environment. Comparative pharmacokinetic analysis revealed B1-PEG’s superior bioavailability at 84.8%, outperforming the unmodified PROTAC molecule B1. When tested in a H3122 xenograft mouse model, B1-PEGsignificantly regressed tumors, underscoring its potential as a formidable candidate in targeted cancer therapy. Our findings offer a promising direction for overcoming bioavailability limitations in PROTAC drug design.

While in the process of designing more effective synthetic opioid rescue agents, we serendipitously identified a new chemotype of potent synthetic opioid. Here, we report that conformational constraint of a piperazine ring converts a mu opioid receptor (MOR) antagonist into a potent MOR agonist. The prototype of the series, which we have termed atoxifent (2), possesses potent in vitro agonist activity. In mice, atoxifent displayed long-lasting antinociception that was reversible with naltrexone. Repeated dosing of atoxifent produced antinociceptive tolerance and a level of withdrawal like that of fentanyl. In rats, while atoxifent produced complete loss of locomotor activity like fentanyl, it failed to produce deep respiratory depression associated with fentanyl-induced lethality. Assessment of brain biodistribution demonstrated ample distribution of atoxifent into the brain with a Tmaxof approximately 0.25 h. These results indicate enhanced safety for atoxifent-like molecules compared to fentanyl.

Synthetic phenolic antioxidants (SPAs) and relevant transformation products (TPs) are potentially neurotoxic pollutants to which humans are widely exposed. However, their penetration behavior across the brain barrier and associated exposure to the central nervous system (CNS) remain unknown. This study is the first to investigate a wide range of 30 SPAs and TPs, including emerging SPAs, in matched serum and cerebrospinal fluid (CSF) samples from children in Guangzhou, China. Sixty-two children of either sex aged <14 years with nonbloody CSF and complete clinical information were included. The findings demonstrated the ubiquitous occurrence of many SPAs and TPs, particularly BHT, 2,4-di-tert-butylphenol (DBP), AO 1010, AO 1076, BHT-Q, and BHT-quinol, not only in serum but also in the CSF. Median total concentrations of SPAs and TPs were up to 22.0 and 2.63 ng/mL in serum and 14.5 and 2.11 ng/mL in CSF, respectively. On calculating the penetration efficiencies across the blood–CSF barrier (BCSFB) (RCSF/serum, CCSF/Cserum)for selected SPAs and TPs, their RCSF/serumvalues (median 0.52–1.41) were highly related to their physicochemical properties, indicating that passive diffusion may be the potential mechanism of BCSFB penetration. In addition, the RCSF/serumvalues were positively correlated with the barrier permeability index RAlb(AlbuminCSF/Albuminserum), indicating that barrier integrity is an important determinant of BCSFB penetration. Overall, these results will improve our perception of human internal exposure to SPAs and lay a solid foundation for assessing the risk of CNS exposure to various SPAs.

Resistance seam welding additive manufacturing (RSAM) is a new solid-state additive manufacturing technique that utilizes pulsed current and pressure to welding powders layer by layer. In this study, Al1060 powder was employed as the raw material to prepare R0 and R10 samples through RSAM technology and subsequent repeated welding processes, respectively. The results showed that, compared to R0, the grain size of the R10 sample decreased from 34.3 μm to 8.7 μm, and the dislocation density increased from 4.355 × 1014to 9.436 × 1014 m−2. Additionally, due to the additional heat and pressure from repeated welding, the porosity decreased from 0.998% to 0.017%, the ultimate tensile strength and elongation improved from 63.5 ± 0.5 MPa and 4.5 ± 0.1% in R0 to 93.3 ± 0.5 MPa and 34.3 ± 0.1% in R10. The improvement in mechanical properties is primarily due to the combined effects of grain refinement, dislocation strengthening, and pore self-healing. This study introduces a feasible new approach for additive manufacturing of aluminum alloys and other materials that is difficult to be additively manufactured by other methods.

Background: Individuals with mild cognitive impairment (MCI) frequently experience sleep disorders, which may elevate the risk of developing Alzheimer’s disease. Yet, sleep types in MCI patients and the factors influencing them have not been sufficiently investigated.Objective: The objective of this study was to explore potential sleep typing and its influencing factors in patients with MCI using latent class analysis.Methods: A cross-sectional survey was conducted in Jiangsu Province, China. Cognitive function in older adults was assessed using neuropsychological tests, including the Montreal Cognitive Assessment Scale-Beijing version (MoCA), the Mini-Mental State Examination (MMSE), the Activities of Daily Living Scale (ADL), and the Clinical Dementia Rating Scale (CDR). Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). Latent class analysis based on PSQI scores and multinomial logistic regression analyses were employed to explore the influencing factors of sleep typing.Results: The study included a total of 611 patients with MCI. Latent class analysis identified three latent classes to categorize the sleep patterns of MCI patients: the good sleep type (56.6%), the insufficient sleep type (29.6%), and the difficulty falling asleep type (13.7%). Potential sleep typing is influenced by gender, chronic disease, physical exercise, social activity, brain exercise, smoking, frailty, subjective cognitive status, and global cognitive function.Conclusions: The findings of this study underscore the notable heterogeneity in the sleep patterns of patients with MCI. Future research may provide targeted prevention and interventions to address the characteristics and influencing factors of patients with different subtypes of sleep MCI.

Breast cancer is one of the major malignant tumors among women worldwide. Long noncoding RNAs (lncRNAs) have been documented as significant modulators in the development and progression of various cancers; however, the contribution of lncRNAs to breast cancer remains largely unknown. In this study, we found a novel lncRNA (NONHSAT137675) whose expression was significantly increased in the breast cancer tissues. We named the novel lncRNA as lncRNA PRBC (PABPC1-related lncRNA in breast cancer) and identified it as a key lncRNA associated with breast cancer progression and prognosis. Functional analysis displayed that lncRNA PRBC could promote autophagy and progression of breast cancer. Mechanistically, we verified that lncRNA PRBC physically interacted with PABPC1 through RIP assay, and PABPC1 overexpression could reverse the inhibiting effect of lncRNA PRBC knockdown on the malignant behaviors in breast cancer cells. Knockdown of lncRNA PRBC interfered the translocation of PABPC1 from nucleus to cytoplasm as indicated by western blot and IF assays. Significantly, the cytoplasmic location of PABPC1 was required for the interaction between PABPC1 and AGO2, which could be enhanced by lncRNA PRBC overexpression, leading to strengthened recruitment of mRNA to RNA-induced silencing complex (RISC) and thus reinforcing the inhibition efficiency of miRNAs. In general, lncRNA PRBC played a critical role in malignant progression of breast cancer by inducing the cytoplasmic translocation of PABPC1 to further regulate the function of downstream miRNAs. This study provides novel insight on the molecular mechanism of breast cancer progression, and lncRNA PRBC might be a promising therapeutic target and prognostic predictor for breast cancer.

Catalytic therapy based on piezoelectric nanoparticles has become one of the effective strategies to eliminate tumors. However, it is still a challenge to improve the tumor delivery efficiency of piezoelectric nanoparticles, so that they can penetrate normal tissues while specifically aggregating at tumor sites and subsequently generating large amounts of reactive oxygen species (ROS) to achieve precise and efficient tumor clearance. In the present study, we successfully fabricated tumor microenvironment-responsive assembled barium titanate nanoparticles (tma-BTO NPs): in the neutral pH environment of normal tissues, tma-BTO NPs were monodisperse and possessed the ability to cross the intercellular space; whereas, the acidic environment of the tumor triggered the self-assembly of tma-BTO NPs to form submicron-scale aggregates, and deposited in the tumor microenvironment. The self-assembled tma-BTO NPs not only caused mechanical damage to tumor cells; more interestingly, they also exhibited enhanced piezoelectric catalytic efficiency and produced more ROS than monodisperse nanoparticles under ultrasonic excitation, attributed to the mutual extrusion of neighboring particles within the confined space of the assembly. tma-BTO NPs exhibited differential cytotoxicity against tumor cells and normal cells, and the stronger piezoelectric catalysis and mechanical damage induced by the assemblies resulted in significant apoptosis of mouse breast cancer cells (4T1); while there was little damage to mouse embryo osteoblast precursor cells (MC3T3-E1) under the same treatment conditions. Animal experiments confirmed that peritumoral injection of tma-BTO NPs combined with ultrasound therapy can effectively inhibit tumor progression non-invasively. The tumor microenvironment-responsive self-assembly strategy opens up new perspectives for future precise piezoelectric-catalyzed tumor therapy.

Hepatocyte-like cells (HLCs) that are differentiated from mesenchymal stem cells (MSCs) provide a valuable resource for drug screening and cell-based regeneration therapy. Differentiating HLCs into 3D spheroids enhances their phenotypes and functions. However, the molecular mechanisms underlying MSCs hepatogenic differentiation are not fully understood. In this study, we generated HLCs from human adipose-derived mesenchymal stem cells (hADMSCs) in both 2D and 3D cultures. We performed an acetyl-proteomics assay on the HLCs derived from both 2D and 3D differentiation and identified a differential change in H3K56 acetylation between the 2 differentiated cells. Our findings revealed that 3D differentiation activated ALB gene transcription by increasing the acetylation level of H3K56, thereby enhancing the phenotypes and functions of HLCs and further promoting their maturation. Notably, inhibiting p300 reduced the acetylation level of H3K56 during hepatogenic differentiation, leading to decreased phenotypes and functions of HLCs, whereas activation of p300 promoted hepatogenic differentiation, suggesting that p300 plays a critical role in this process. In summary, our study demonstrates a potential mechanism through which 3D spheroids differentiation facilitates hADMSCs differentiation into HLCs by promoting p300-mediated H3K56 acetylation, which could have significant clinical applications in liver regeneration and disease modeling.Graphical Abstract

The diagnostic value of cerebrospinal fluid chemokine c-x-c motif ligand 13 (CSF CXCL13) for neurosyphilis was assessed by meta-analysis in this study. PubMed, Web of Science and Embase databases were searched to identify relevant articles by using MeSH and free terms of CXCL13 and neurosyphilis. A total of 720 syphilis and 338 neurosyphilis individuals in 6 articles were involved in this meta-analysis. The pooled sensitivity and specificity were 0.82 (95% confidence intervals (CI), 0.77–0.87) and 0.84 (95% CI, 0.79–0.87). The pooled positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and the area under receiver operating characteristic curve were 5.10 (95% CI, 3.90–6.60), 0.21 (95% CI, 0.16–0.28), 24.00 (95% CI, 14.00–39.00) and 0.88 (95% CI, 0.84–0.90), respectively. In subgroup analysis, human immunodeficiency virus infection and diagnostic criteria for neurosyphilis were identified to be associated with heterogeneity. Based on limited evidence, CSF CXCL13 can be helpful in diagnosing neurosyphilis.

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid (CSF) flow by beating their motile cilia coordinately. The ependymal denudation or ciliary dysfunction causes hydrocephalus. Here, we report that the deficiency of regulator of G-protein signaling 22 (RGS22) results in severe congenital hydrocephalus in both mice and rats. Interestingly, RGS22 is specifically expressed in ependymal cells within the brain. Using conditional knock-out mice, we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce hydrocephalus. Mechanistically, we show that Rgs22 deficiency leads to the ependymal denudation and impaired ciliogenesis. This phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor (LPAR) signaling under Rgs22-/-condition, as the LPAR blockade effectively alleviates hydrocephalus in Rgs22-/-rats. Therefore, our findings unveil a previously unrecognized role of RGS22 in the central nervous system, and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

Clinical ethics consultations (CECs) play an important role in resolving ethical issues in clinical practice worldwide. The government has encouraged the development of CECs in China to address the ethical challenges arising in prenatal diagnosis. So far, the current state and challenges facing CEC remain understudied. This study aimed to explore the perspectives of employees on ethics committees for prenatal diagnosis in 13 medical institutions in Hunan Province, China. Twenty-eight employees participated in interviews. Our qualitative approach employed content analysis to identify major themes in interviewees’ responses, which covered the composition and vision of their prenatal diagnosis ethics committee, as well as the challenges they faced. The results show that CEC in China is in an exploratory stage, with models for CEC composition, and workflow varying significantly. Therefore, we propose the future direction of efforts to improve CECs, including improving CEC working mechanisms and operating procedures, strengthening ethical training for healthcare workers and ethics committee employees, and developing more specific ethical guidance based on the accumulated experiences of ethics committee employees in the early development of CEC for prenatal diagnosis.

Peripheral nerve injury (PNI) is a common clinical challenge, requiring timely and orderly initiation of synergistic anti-inflammatory and reparative therapy. Although the existing cascade drug delivery system can realize sequential drug release through regulation of the chemical structure of drug carriers, it is difficult to adjust the release kinetics of each drug based on the patient's condition. Therefore, there is an urgent need to develop a cascade drug delivery system that can dynamically adjust drug release and realize personalized treatment. Herein, we developed a responsive cascade drug delivery scaffold (RCDDS) which can adapt to the therapeutic time window, in which Vitamin B12 is used in early controllable release to suppress inflammation and nerve growth factor promotes regeneration by cascade loading. The RCDDS exhibited the ability to modulate the drug release kinetics by hierarchically opening polymer chains triggered by ultrasound, enabling real-time adjustment of the anti-inflammatory and neuroregenerative therapeutic time window depending on the patient's status. In the rat sciatic nerve injury model, the RCDDS group was able to achieve neural repair effects comparable to the autograft group in terms of tissue structure and motor function recovery. The development of the RCDDS provides a useful route toward an intelligent cascade drug delivery system for personalized therapy.

Triple-negative breast cancer (TNBC) is an exceptionally aggressive subtype of breast cancer. Despite the recognized interplay between tumors and tumor-associated macrophages in fostering drug resistance and disease progression, the precise mechanisms leading these interactions remain elusive. Our study revealed that the upregulation of collagen type V alpha 1 (COL5A1) in TNBC tissues, particularly in chemoresistant samples, was closely linked to an unfavorable prognosis. Functional assays unequivocally demonstrated that COL5A1 played a pivotal role in fueling cancer growth, metastasis, and resistance to doxorubicin, both in vitro and in vivo. Furthermore, we found that the cytokine IL-6, produced by COL5A1-overexpressing TNBC cells actively promoted M2 macrophage polarization. In turn, TGFβ from M2 macrophages drived TNBC doxorubicin resistance through the TGFβ/Smad3/COL5A1 signaling pathway, establishing a feedback loop between TNBC cells and macrophages. Mechanistically, COL5A1 interacted with TGM2, inhibiting its K48-linked ubiquitination-mediated degradation, thereby enhancing chemoresistance and increasing IL-6 secretion. In summary, our findings underscored the significant contribution of COL5A1 upregulation to TNBC progression and chemoresistance, highlighting its potential as a diagnostic and therapeutic biomarker for TNBC.

Modular multilevel converters (MMC) have the characteristics of high modularity, good availability and high-power quality. Thus, they are widely used in medium and high-power applications. To meet large capacity application requirements, a large number of capacitors is applied in parallel and series. However, capacitors are one of the most vulnerable components in MMCs. To identify abnormal capacitors, a condition monitoring method for capacitors is proposed in this paper using the cumulative sum detection of the sliding window algorithm. First, the bilateral cumulative sum algorithm of the sliding window is proposed to extract the switch-on time and switch-off time of the submodules (SMs). Second, the capacitance is calculated using the monitored capacitor voltage and arm current during the switch-on status. Finally, the accuracy and effectiveness of the proposed method are verified by an MMC system operating condition simulated experiment platform. The proposed condition monitoring method simplifies the calculation of capacitance with a high accuracy by removing the requirement of measuring the switching signal. In addition, it does not have an adverse influence on the normal operation of MMC systems.

The heat transfer of power devices has the characteristics of multitimescale. However, the traditional thermal network model is difficult to predict the temperature information of power devices at multitimescale accurately. This article proposes a multitimescale thermal network model for power devices, with metal-oxide-semiconductor field-effect-transistor (mosfet) as an example. First, we establish a finite-element model for temperature calculation of power devices and then reduce the order of the finite-element model based on the proper orthogonal decomposition algorithm. The reduced-order model is converted into an equivalent circuit model by the node voltage method and integrated into the circuit simulation software. To demonstrate its general applicability, this article also establishes thermal network models for both insulated gate bipolar transistor (IGBT) and SiC mosfet devices, and validates the multitimescale thermal network models through ANSYS/transient thermal software and experiments. The temperature calculation results of the three power devices all indicate that the proposed multitimescale thermal network model can calculate the temperature of power devices faster than the ANSYS/transient thermal model and has less than 5% error under test conditions. This article is accompanied by a video demonstrating a comparison of the computational speed of the multitimescale thermal network model with a finite-element model. Finally, a case study of junction temperature calculation in a buck converter is presented to illustrate the application method of the thermal network model.

Aims: To explore the associations between visit-to-visit lipid variability and risk of ischemic heart disease (IHD) in a population-based cohort in China. Methods: We evaluated lipid variability in 30,217 individuals from the Yinzhou Health Information System who had ≥3 recorded lipid measurements during 2010–2014. We used various indicators including standard deviation (SD), coefficient of variation (CV), variability independent of the mean (VIM), and average real variability (ARV) to quantify the variability in triglycerides, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Overall, a total of 1305 participants with IHD were identified during the follow-up of 194,421 person-years. Subjects in Q4 had a 21% elevated risk of IHD (HR = 1.21, 95% CI: 1.03–1.41) for LDL-C variability (CV) compared with the reference (Q1). The HRs for Q4 vs Q1 were 1.21 (95% CI: 1.04–1.42) for HDL-C variability, and 1.28 (95% CI: 1.10–1.50) for TC variability. However, no association was observed between triglycerides variability and risk of IHD. Conclusions: Higher variability in LDL-C, HDL-C, and TC levels was associated with an elevated risk of IHD, suggesting that lipid variability could be considered as an independent risk factor of IHD.

The ever-growing application of miniaturized electric devices calls for the manufacturing of energy storage systems with a high areal energy density. Thick electrode design is a promising strategy to acquire high areal energy density by enhancing active mass loading and minimizing inactive components. However, the sluggish reaction kinetics and poor electrode mechanical stability that are accompanied by the increased electrode thickness remain unsolved problems. Herein, for the first time, we propose a novel chemical cross-linking strategy to fabricate GeP thick electrodes with adjustable electrode thicknesses and active mass loadings for high areal capacity sodium-ion batteries (SIBs). The chemical cross-linking between carboxylic multiwalled carbon nanotubes (CNTs) and pyrolysis cellulose nanofibers (CNFs) forms a 3D network that encloses GeP nanoparticles, which guarantees fast charge transfer, efficient stress relief, and alleviated volume expansion/shrinkage of the electrode. The hierarchical porous structure generates numerous interconnected channels for unfettered Na+diffusion, ensuring uncompromised reaction kinetics as the electrode thickness increases. As a result, the ultrathick 1031 μm GeP@C–CNTs-CNFs electrode featuring a mass loading of 18.3 mg cm–2delivers an ultrahigh areal capacity of 10.58 mAh cm–2accompanied by superior cycling stability, which outperforms all reported Ge-based electrodes (generally below 1.5 mAh cm–2). This work sheds insightful light on designing high areal capacity flexible thick electrodes for the applications of miniaturized electric devices.

Biodegradable polymers (BPs), as fundamental materials for implantable biodegradable medical electronic device (IBMED) fabrication, can be used to prepare the encapsulation layer, substrate, and sensing materials of IBMEDs and the triboelectric materials of implantable triboelectric nanogenerators (TENGs) in particular. The basic properties of these materials determine IBMED performance and application. However, few studies have compared the basic properties of a comprehensive range of BPs, especially in terms of their triboelectric performances and related laws. Here, a comprehensive range of 40 kinds of triboelectric BP films were prepared and tested for triboelectric polarities and degradation in a uniform state. Particularly, we developed a triboelectric series based on these BPs and innovatively summarized the regularities and principles of influence of various main- or side-chain chemical groups on the triboelectric polarities of BPs. This study can not only help researchers to gain insight into the underlying mechanisms of triboelectrification of polymers but also provides important guidance for material selection, especially for the selection of triboelectric BPs for TENG-based IBMEDs in regard to basic research and application.

Cross‐affiliation emerges as a new and fast‐developing means to promote collaboration in financial research. We find that the average number of affiliations reported per author in the top‐three finance journals increases steadily from 1.1 to 1.3 from 1995 to 2016. Scale‐free power laws characterize the resulting highly‐skewed distributions of top finance journal publications of worldwide institutions. We propose an explanation of the scale‐invariance, based on a network model featuring nonlinear growth and linear preferential attachment. The model indicates that success‐breeds‐success engenders 87% of total publications and hence the dispersion in research output, while accelerated growth of collaboration reduces the heterogeneity.

A proton corridor environment was regulated in Zn@Cu nanowire arrays catalyst with ZnO top hats, leading a superior ethane selectivity and high current density and revealing the mechanisms affecting the selective conversion between ethane and ethylene.