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3. Oral fexinidazole for late-stage African Trypanosoma brucei gambiensetrypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial

Author

Mesu, Victor Kande Betu Ku, Kalonji, Wilfried Mutombo, Bardonneau, Clélia, Mordt, Olaf Valverde, Blesson, Séverine, Simon, François, Delhomme, Sophie, Bernhard, Sonja, Kuziena, Willy, Lubaki, Jean-Pierre Fina, Vuvu, Steven Lumeya, Ngima, Pathou Nganzobo, Mbembo, Hélène Mahenzi, Ilunga, Médard, Bonama, Augustin Kasongo, Heradi, Josué Amici, Solomo, Jean Louis Lumaliza, Mandula, Guylain, Badibabi, Lewis Kaninda, Dama, Francis Regongbenga, Lukula, Papy Kavunga, Tete, Digas Ngolo, Lumbala, Crispin, Scherrer, Bruno, Strub-Wourgaft, Nathalie, and Tarral, Antoine

Abstract

Few therapeutic options are available to treat the late-stage of human African trypanosomiasis, a neglected tropical disease, caused by Trypanosoma brucei gambiense(g-HAT). The firstline treatment is a combination therapy of oral nifurtimox and intravenous eflornithine that needs to be administered in a hospital setting by trained personnel, which is not optimal given that patients often live in remote areas with few health resources. Therefore, we aimed to assess the safety and efficacy of an oral regimen of fexinidazole (a 2-substituted 5-nitroimidazole with proven trypanocidal activity) versus nifurtimox eflornithine combination therapy in patients with late-stage g-HAT.

Published
2018
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