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This study delves into the micro-occurrence states and enrichment mechanisms of residual oil, pivotal for advancing the production from tight sandstone reservoirs, particularly from the Chang 8 Member of the Upper Triassic Yanchang Formation, Ordos Basin. Through an analysis of 23 core samples, employing high-pressure mercury injection, field emission scanning electron microscopy, thin section, and X-ray diffraction techniques, distinct reservoir types were categorized. The utilization of environmental scanning electron microscope, multi-solvent continuous extraction, and an oil components separation system facilitated an intricate analysis of residual oil micro-occurrence states and their subsequent effects on porosity and permeability reduction across varying reservoir types. The findings accentuate the integral role of reservoir type in determining residual oil distribution within tight sandstone reservoirs. Favorable pore throat sorting and connectivity in specified reservoir types are identified as conducive to residual oil enrichment with a higher concentration of light components. In contrast, elevated carbonatite and clay content in other reservoir types leads to adsorption of heavy components, disrupting pore throat connectivity, and impeding crude oil filling. The varied interactions between oil and rock, oil–oil, and pore throat sealing significantly impact the distribution of oil components of residual oil, culminating in a notable reduction of porosity and permeability by 2.63% and 0.197 mD, with corresponding reduction rates of 27.19% and 46.69%, respectively. The insights derived from this study furnish a theoretical foundation for augmenting tight oil recovery and comprehending the enrichment mechanism of residual oil driven by the heterogeneity of tight sandstone reservoirs.

Brachytherapy stands as an essential clinical approach for combating locally advanced tumors. Here, an injectable brachytherapy hydrogel is developed for the treatment of both local and metastatic tumor. Fe‐tannins nanoparticles are efficiently and stably radiolabeled with clinical used therapeutic radionuclides (such as 131I, 90Y, 177Lu, and 225Ac) without a chelator, and then chemically cross‐linked with 4‐armPEG‐SH to form brachytherapy hydrogel. Upon intratumoral administration, magnetic resonance imaging (MRI) signal from ferric ions embedded within the hydrogel directly correlates with the retention dosage of radionuclides, which can real‐time monitor radionuclides emitting short‐range rays in vivo without penetration limitation during brachytherapy. The hydrogel's design ensures the long‐term tumor retention of therapeutic radionuclides, leading to the effective eradication of local tumor. Furthermore, the radiolabeled hydrogel is integrated with an adjuvant to synergize with immune checkpoint blocking therapy, thereby activating potent anti‐tumor immune responses and inhibiting metastatic tumor growth. Therefore, this work presents an imageable brachytherapy hydrogel for real‐time monitoring therapeutic process, and expands the indications of brachytherapy from treatment of localized tumors to metastatic tumors. A brachytherapy hydrogel chelator‐freely radiolabeling various therapeutic radionuclides is developed. The hydrogel after local administration ensures long‐term tumor retention of radionuclides for magnetic resonance imaging guided oncolysis. In addition, the hydrogel loading adjuvant is combined with immune checkpoint inhibitors to activate anti‐tumor immune response for effective treatment of both primary and metastatic tumors.

Under extreme conditions of low temperature or fast charging, the side reaction of lithium (Li) plating can occur on the anode surface of lithium-ion batteries (LIBs), which may cause causing capacity fade. Alarmingly, in severe cases, dendrites will grow and pierce the separator. As a result, thermal runaway will be induced, which seriously affects the safety performance of LIBs. Along these lines, to avoid Li plating during the charging process, the safe charging strategy was thoroughly investigated in this work based on the implementation of the three-electrode equivalent circuit model (ECM). More specifically, for the three-electrode LIB implanted with a reference electrode (RE), its ECM was improved based on the traditional ECM. The cathode and anode of the LIB were decoupled through the RE, whereas combined with the heat generation, transfer, and aging characteristics, a first-order RC electro-thermal coupled model of three-electrode was established, and the semi-empirical aging model of the LIB was combined to analyse the coupling characteristics between the parameters of each model. According to the acquired experimental data, the key parameters of modelling were identified and the accuracy of the model was verified. In addition, aiming at the contradiction between the fast charging and aging speed, and combined with the NSGA-II optimization algorithm, the self-adaptive multi-stage constant current constant voltage (SMCCCV) charging strategy was also proposed to avoid Li plating on the anode surface. An optimization model was thus established with the charging time and aging loss as the objective functions, resulting in three charging strategies, namely minimum charging time, minimum aging, and balanced charging. From the simulated outcomes, it was demonstrated that the anode potential was strictly maintained above the safety threshold for these three strategies. On top of that, the balanced charging strategy reduced the aging loss by 11.5 %, while the relatively equivalent charging speed compared with the traditional constant current constant voltage (CCCV) strategy was maintained. The proposed safe charging strategy based on multi-objective optimization provides some valuable insights for next-generation fast charging techniques.

Myxoid leiomyosarcoma is a malignant tumor that originates from the mesenchymal tissue with extensive mucoid degeneration. It usually occurs in the uterus; occurrences from other tissues are extremely rare. Here we report the FDG PET/CT findings and clinicopathological of primary pleura myxoid leiomyosarcoma in a 51-year-old man.

Although bone involvement is reported as uncommon in hepatocellular carcinoma (HCC), its incidence has significantly increased in the last decade due to the improvement of overall survival of these patients. Bone metastasis is discovered as the first symptoms in about 5%–7% of the HCC patients, which would cause clinical misdiagnosis easily. In this case report, the patient was diagnosed as primary femoral benign tumor initially. Axial skeleton is the most frequent localization of bone metastases, but hip joint and femur metastases were rare reported. Bone scintigraphy can be an option for patients to reduce the misdiagnosis rate and to rule out the possibility of bone metastasis from HCC.

•A complete battery pack model is established.•The optimization objectives of time, aging, and energy loss are established.•A genetic algorithm is used to optimize current.•Optimization of battery pack charging strategy.