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Objective: The aim of this study was to develop and test a prototype of a deep learning surgical guidance system [computer-assisted staging laparoscopy (CASL)] that can intraoperative identify peritoneal surface metastases on routine laparoscopy images. Background: For a number of cancer patients, operative resection with curative intent can end up in early recurrence of the cancer. Surgeons misidentifying visible peritoneal surface metastases is likely a common reason. Methods: CASL was developed and tested using staging laparoscopy images recorded from 132 patients with histologically confirmed adenocarcinoma involving the gastrointestinal tract. The data included images depicting 4287 visible peritoneal surface lesions and 3650 image patches of 365 biopsied peritoneal surface lesions. The prototype's diagnostic performance was compared with results from a national survey evaluating 111 oncologic surgeons in a simulated clinical environment. Results: In a simulated environment, surgeons' accuracy in correctly recommending a biopsy for metastases while omitting a biopsy for benign lesions was only 52%. In this environment, the prototype of a deep learning surgical guidance system demonstrated improved performance in identifying peritoneal surface metastases compared to oncologic surgeons with an area under the receiver operating characteristic curve of 0.69 (oncologic surgeon) versus 0.78 (CASL) versus 0.79 (human-computer combined). A proposed model would have improved the identification of metastases by 5% while reducing the number of unnecessary biopsies by 28% compared with current standard practice. Conclusions: Our findings demonstrate a pathway for an artificial intelligence system for intraoperative identification of peritoneal surface metastases but still require additional development and future validation in a multi-institutional clinical setting. [ABSTRACT FROM AUTHOR]

This study investigates the biological functions of Tripartite motif-containing 3 (TRIM3) in endometrial cancer (EC). The expression patterns of TRIM3 in EC using the UALCAN and Kaplan-Meier Plotter databases, and investigated the relationship with the progression of EC in patients. EC cell lines, Ishikawa and HEC-1A were transfected with a vector expressing TRIM3 after pre-treated with/without pifithrin-α (an inhibitor of p53). Subsequently, in vitro cell proliferation and apoptosis were evaluated. Overexpression of TRIM3 resulted in inhibition of cell viability and clone formation and induced G1 phase arrest in Ishikawa and HEC-1A cells. Additionally, after TRIM3 was overexpressed, cell apoptosis was increased, and higher levels of Bax and lower levels of B-cell lymphoma-2 (Bcl-2) were observed in cells. Furthermore, heightened levels of p53 and p21 proteins were observed in Ishikawa and HEC-1A cells overexpressing TRIM3. However, pifithrin-α could counteract the effects of TRIM3 overexpression on EC cells. These data indicate that TRIM3 exerts a tumor suppressor effect in EC by activating the p53/p21 pathway. [ABSTRACT FROM AUTHOR]

High water cut reservoirs and edge and bottom water reservoirs have become the focus of conventional oil and gas production research due to the defects of low recovery efficiency and reservoir dispersion. Based on the reservoir distribution characteristics of edge and bottom water reservoirs, this study studied a low polarity surfactant to study the influence of different factors on the special water drive efficiency of edge and bottom water reservoirs in Huanjiang Oilfield, and analyzed the microscopic mechanism of surfactant enhancing water drive efficiency. The research results show that compared with the traditional water drive, the enhanced water drive with surfactant can increase the oil displacement efficiency to 85%, which is far higher than 60% of the traditional water drive. In addition, the residual oil saturation of the core can be reduced to 0.35 by adding surfactant to the water drive system, which is much lower than 0.48 of the traditional water drive system. Optimizing the cross pattern of injection wells can also improve the water drive efficiency. When the injection wells cross, the displacement efficiency and remaining oil saturation of the edge and bottom water reservoirs reach 85% and 0.36 respectively, which are much higher than those of traditional water flooding. By changing the water drive system composition of edge and bottom water reservoirs, the oil displacement efficiency and crude oil recovery of edge and bottom water reservoirs can be improved to a certain extent, and the basic ideas for the exploration and development of edge and bottom water reservoirs can also be provided. [ABSTRACT FROM AUTHOR]

The comprehensive treatment of stripped and deficient wells is the only way to achieve the goal of increasing production in Huanjiang Chang 8 reservoirs. With the gradual exploitation of this oilfield, the water cut and the number of stripped and deficient wells increases day by day, which seriously affects the development effect of the research area. Based on the data of production dynamics in the research area, the causes of stripped and deficient wells were analyzed, and the wells were divided into high water cut type in the early stage of production, rapid increase in water cut type, low production fluid well in the early stage of production and continuous decrease in fluid volume. This research includes some static parameters such as permeability, oil thickness and initial water saturation of stripped and deficient wells in the research area, and some dynamic parameters such as pressure level, water injection intensity and injection-production pressure. Firstly, partial correlation analysis is used to analyze the correlation of the ten static and dynamic parameters. Secondly, the main causes leading to four types of stripped and deficient wells are sorted to provide theoretical basis for clarifying the causes of stripped and deficient wells. Finally, the corresponding treatment countermeasures are put forward according to the influence of different causes. The results show that the causes of stripped and deficient wells of high-water-bearing wells and water-bearing rapidly rising wells in the research area are mainly caused by the number of fractures per well, interlayer thickness and original water saturation. In order to control these two types of low-producing wells, separate injection and water plugging treatment can be carried out. However, the stripped and deficient wells with low production and continuous decrease of fluid volume are mainly caused by the heterogeneity of reservoir thickness, transformation intensity and reservoir permeability. This type of low production wells can be treated by filling holes, sidetracking and repeated fracturing measures. Taking the L area of Chang 8 Reservoir in Huanjiang Oilfield as an example, the above measures were implemented for four different low-producing Wells respectively. The results show overall water cut in the research area decreased 12.9% and the average single well production increased by 28.6% after the comprehensive treatment. [ABSTRACT FROM AUTHOR]

Evodiamine (EVO) exerts anti-cancer effect in a majority of cancer cells. BGC-823 and SGC-7901 cells were used to study EVO-induced cytotoxicity in human gastric cancer cell. Our results demonstrated that EVO exposure elicited cell vialibility decrease and G2/M arrest caused by induction of cdc2/cyclin B1 complex activation. EVO also induced caspase-dependent apoptosis and necroptosis caused by induction of actication of RIP, RIP3 and MLKL. Moreover, increase of reactive oxygen species (ROS) levels and cytotoxicity induced by EVO were significantly attenuated by co-treatment with a ROS scavenger, EUK134. In conclusion, EVO induced ROS-dependent cytotoxicity, which may involve apoptosis and necroptosis, in human gastric cancer cells. [ABSTRACT FROM AUTHOR]

This study was intended to determine the factors that affect employees’ green behavior. Accordingly, the authors developed a framework that depicts the relations between psychological contract fulfilment, job crafting, social relationships (guanxi), and employees’ green behavior. Convenience sampling was adopted, through which we obtained cross-sectional data on 688 salespersons from enterprises in Nanning, Guangxi. SPSS, AMOS, and SmartPLS were used in the data analysis. The results of this research have important reference value for business managers to improve enterprises’ sustainable development. They revealed that psychological contract fulfilment affected job crafting and employees’ green behavior positively, as well as job crafting’s mediating effect. Guanxi did not moderate the effect of transactional psychological contracts on employees’ green behavior, but did moderate the positive effect of relational psychological contracts on employees’ green behavior negatively. [ABSTRACT FROM AUTHOR]

Transient faults occur in computation units of a processor, which can cause control flow errors (CFEs) and compromise system reliability. The software-based methods perform illegal control flow detection by inserting redundant instructions and monitoring signature. However, the existing methods not only have drawbacks in terms of performance overhead, but also lack of configurability. We propose a configurable approach CCFCA for detecting CFEs. The configurability of CCFCA is implemented by analyzing the criticality of each region and tuning the detecting granularity. For critical regions, program blocks are divided according to space-time overhead and reliability constraints, so that protection intensity can be configured flexibly. For other regions, signature detection algorithms are only used in the first basic block and last basic block. This helps to improve the fault-tolerant efficiency of the CCFCA. At the same time, CCFCA also has the function of solving confusion and instruction self-detection. Our experimental results show that CCFCA incurs only 10.61% performance overhead on average for several C benchmark program and the average undetected error rate is only 9.29%. CCFCA has high error coverage and low overhead compared with similar algorithms. This helps to meet different cost requirements and reliability requirements. [ABSTRACT FROM AUTHOR]

Silent Data Corruptions (SDCs) is a serious reliability issue in many domains of computer system. The identification and protection of the program instructions that cause SDCs is one of the research hotspots in computer reliability field at present. A lot of solutions have already been proposed to solve this problem. However, many of them are hard to be applied widely due to time-consuming and expensive costs. This paper proposes an intelligent approach named SDCPredictor to identify the instructions that cause SDCs. SDCPredictor identifies SDC-causing Instructions depending on analyzing the static and dynamic features of instructions rather than fault injections. The experimental results demonstrate that SDCPredictor is highly accurate in predicting the SDCs proneness. It can achieve higher fault coverage than previous similar techniques in a moderate time cost. [ABSTRACT FROM AUTHOR]

Abstract In smart grid, smart meter (SM) samples users' energy consumption at high frequency. By analyzing the fine-grained smart metering data, users' behavior patterns can be recognized thus threatening consumers' privacy. In this paper, the protection of SM privacy is studied in the presence of solar energy generation system and a rechargeable battery (RB). Solar energy plays the role of an alternative electricity provider for users except power grid. RB can be used to partially hide the real appliance consumption while cut down the electricity bills. A "privacy safe-cost friendly optimal model" is developed aimed at minimizing the weighted sum of privacy leakage and financial cost, with constraints of battery physical conditions and solar radiation amount. In order to solve the optimal problem, we formulate a novel inner-outer optimal algorithm. Simulations demonstrate the efficacy of the proposed algorithm using real data. The impact of the battery capacity and the amount of solar energy on the privacy protection is also studied. [ABSTRACT FROM AUTHOR]

Objective: To study the distribution of human papillomavirus (HPV) genotypes in population of hospital opportunistic screening and the relationship with cervical intraepithelial neoplasia (CIN) among women. Materials and Methods:A retrospective analysis was performed in 14,991 women who were undergoing HPV genotype testing and 253 inpatients who were undergoing conization pathological with CIN and with pre-HPV test at Jiangsu University Hospital between July 2013 and July 2015. Results: Of these, 25.99% were infected by HPV and 20.37% for high-risk HPV (hr-HPV), the highest prevalence of hr-HPV and multiple hr-HPV were all in the 55- to 64-year-old group (Χ² = 37.125, p < 0.01, Χ² = 43.668, p < 0.01). The most prevalent genotype is HPV52, then descending order were HPV16 and 58. On the basis of 253 inpatients, CIN I were 78, CIN II were 67, CIN III were 108. Before conization, hr-HPV positive in CIN I lesions were 74.36% (58/78) and CIN II were 94.03% (63/67), while in CIN III lesions there were 94.44% (102/108) (Χ² =17.936, p < 0.01). The most frequent HPV genotype was HPV 16, followed by HPV 58 and 52. Infection with multiple- hr-HPV seemed to have no relationship with the severity of pathology increased (Χ² =1.888, p > 0.01). Conclusion: This study established the prevalence of HPV genotypes that is similar to the population of CIN, except HPV 16 and HPV 52, 58 were also found in a large proportion of women, HPV 18 was not the most important. Therefore, in the future, a HPV vaccine covering HPV 52/16/58 should be used in this region compared to the currently available vaccine for the prevention strategy in the population [ABSTRACT FROM AUTHOR]

Dynamically checking the integrity of software at run-time is always a hot and difficult spot for trusted computing. Control-flow integrity is a basic and important safety property of software integrity. Many classic and emerging security attacks who introduce illegal control-flow to applications can cause unpredictable behaviors of computer-based systems. In this paper, we present a software-based approach to checking violation of control flow integrity at run-time. This paper proposes a high-performance and low-overhead software control flow checking solution, control flow checking at virtual edges (CFCVE). CFCVE assigns a unique signature to each basic block and then inserts a virtual vertex into each edge at compile time. This together with insertion of signature updating instructions and checking instructions into corresponding vertexes and virtual vertexes. Control flow faults can be detected by comparing the run-time signature with the saved one at compile time. Our experimental results show that CFCVE incurs only 10.61% performance overhead on average for several C benchmark programs and the average undetected error rate is only 9.29%. Compared with previous techniques, CFCVE has the characteristics of both high fault coverage and low memory and performance overhead. [ABSTRACT FROM AUTHOR]

Ball milling process has an important effect on the microstructure and the morphology of final powder products and the corresponding as-sintered samples. In the present study, Ti-7Al-0.2B (wt%) mixed powder was ball-milled by low-energy and high-energy types of ball mills, and then the milled powder was sintered by hot-pressing. On this basis, the morphology evolution of the powder was analyzed, and the microstructures of the reinforcements in the as-sintered composite were investigated. Research results show that in the low-energy ball milling process, mechanical alloying occurs between the powder particles. TiB whiskers formed in sintering process are long and thin without linked coarse crystals bars or clusters. Under the high-energy milling, the average particle size of the powder is refined remarkably to 1 μm, and Ti(Al) supersaturated solid solution or even amorphous structure is formed during the milling process. In the following sintering process, nano-scale TiB whiskers are synthesized and they are uniformly distributed in the matrix. [ABSTRACT FROM AUTHOR]