1. Programmable Adaptive Anti-Retention Module for Capsule Endoscopy Based on Durable and Ultra-Wide Range Pressure Sensor
- Author
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Zhou, Cheng, Wang, Weicheng, Jiang, Jinlei, Wang, Wei, Tang, Ning, Liu, Yamin, Xue, Shenghao, Guo, Yiping, Cui, Daxiang, and Li, Qichao
- Abstract
Capsule endoscopy (CE) enables noninvasive examination of the gastrointestinal (GI) tract. However, there is still no viable way to solve capsule retention (CR), which is the most worrisome complication of CE in a clinic. The CR rate did not decrease with the continuous development of the CE. Here, we proposed a novel approach that fabricated a programmable adaptive anti-retention module (PARM) with a small size and integrated it into the capsules to alleviate the retention of the capsules in the GI tract. We developed a durable, ultrawide range and highly sensitive pressure sensor, along with four different trigger logic circuits, to construct four PARMs with diverse application potentials. The miniature PARM is capable of detecting pressure and adapting to trigger vibration at a very high frequency based on the preset pressure program, or alternatively, the vibration can be controlled wirelessly according to the pressure values. Ex vivo and in vivo experiments have demonstrated that PARM can effectively relieve the blockage of capsules in the intestines and promote intestinal peristalsis. The proposed PARM is a positive exploration and attempts to alleviate the CR problem, demonstrating the significant potential for reducing the CR rate in a clinic.
- Published
- 2024
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