11 results on '"Lessmann V"'
Search Results
2. Nursing-bottle syndrome caused by prolonged drinking from vessels with bill-shaped extensions.
- Author
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Behrendt A, Sziegoleit F, Müler-Lessmann V, Ipek-Özdemir G, and Wetzel W
- Published
- 2001
3. BDNF: a regulator of learning and memory processes with clinical potential
- Author
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Brigadski, T. and Leßmann, V.
- Abstract
Memories are believed to be represented by facilitated synaptic transmission of electrical signals in neuronal networks. The ability to acquire new memories or to change old memory content results from the plastic properties of the brain. Molecular changes in synaptic plasticity of neuronal networks are considered to be the cellular correlates of learning and memory, and the neurotrophin brain-derived neurotropic factor (BDNF) plays an important role in these processes. This neurotrophic factor coordinates a multitude of biological functions. In addition to its role in neuronal plasticity processes, such as long-term potentiation of synaptic transmission, the protein regulates the differentiation of neuronal precursor cells, synaptogenesis, and neuronal survival. Cellular processes like BDNF protein processing, anterograde and retrograde transport, as well as exocytosis and endocytosis of BDNF vesicles are necessary to enable the protein to fulfill its neuroprotective and plasticity-related functions in its target areas. Therefore, deficits in one of these functions, resulting in a reduction or a lack of BDNF supply, can result in dysfunctional or reduced synaptic plasticity in virtually every brain area. Since cognitive processes and mental health require the intact formation and modification of memory traces, a change in BDNF turnover is considered as a contributing factor to a number of neurodegenerative and psychological disorders. This review summarizes the current knowledge regarding the connection between BDNF, its role in synaptic plasticity and its role in brain.
- Published
- 2014
- Full Text
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4. Cyclic AMP endogenously enhances synaptic strength of developing glutamatergic synapses in serum-free microcultures of rat hippocampal neurons
- Author
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Lessmann, V. and Heumann, R.
- Published
- 1997
- Full Text
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5. BDNF-GFP containing secretory granules are localized in the vicinity of synaptic junctions of cultured cortical neurons.
- Author
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Haubensak, W, Narz, F, Heumann, R, and Lessmann, V
- Abstract
The protein family of mammalian neurotrophins, comprising nerve-growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 and -4/5 (NT-3, NT-4/5), supports the survival and the phenotype of neurons from the central as well as the peripheral nervous system (CNS, PNS). In addition, exogenous application of neurotrophins has recently been found to modulate synaptic transmission in the rodent CNS. However, to provide evidence for a role of neurotophins as endogenous fast acting modulators of synaptic transmission, the synaptic localization and secretion of neurotrophins needs to be shown. We have now constructed a fusion protein consisting of N-terminal BDNF (the most abundant neurotrophin in the rodent hippocampus and neocortex) and C-terminal green fluorescent protein (GFP) to elucidate the cellular localization of BDNF in cortical neurons. Transient expression of BDNF-GFP in COS-7 cells revealed that the cellular localization in the trans-Golgi network (TGN), the processing of precursor proteins and the secretion of mature BDNF-GFP is indistinguishable from the properties of untagged BDNF. Upon transient transfection of primary rat cortical neurons, BDNF-GFP was found in secretory granules of the regulated pathway of secretion, as indicated by colocalization with the secretory granule marker secretogranin II. BDNF-GFP vesicles were found in the neurites of transfected neurons with a pattern reminiscent of the localization of endogenous BDNF in untransfected cortical neurons. BDNF-GFP vesicles were found predominantly in the somatodendritic compartment of the neurons, whereas additional axonal localization was found less frequently. Immunocytochemical staining of synaptic terminals with synapsin I antibodies revealed that the density of BDNF-GFP vesicles is elevated in the vicinity of synaptic junctions, indicating that BDNF is localized appropriately to function as an acute modulator of synaptic transmission. These data suggest that BDNF-GFP will be a useful tool to investigate synaptic release of BDNF during physiological synaptic stimulation, and will thereby allow us to elucidate the participation of neurotrophin release in activity dependent synaptic plasticity.
- Published
- 1998
6. Abstract of the 68th Meeting (Spring Meeting) 6–9 March 1990, Heidelberg
- Author
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Sakmann, B., Schrader, J., Brenner, B., Murer, H., Boeckh, J., Handwerker, H. O., HonerjÄger, P., Dugas, M., Wang, G., DeLuca, A., Brinkmeier, H., Fakler, B., Pröbstle, T., Rüdel, R., Pohl, J. -A., Meves, H., Kroll, B., Bremer, S., Tümmler, B., Frömter, E., Schwegler, J. S., Steigner, W., Silbernagl, S., Pusch, Michael, Niemann, P., Schmidtmayer, J., Ulbricht, W., Hansen, G., Lönnendonker, U., Neumcke, B., Eickhorn, R., Hornung, D., Antoni, H., Penner, R., Neher, E., Takeshima, H., Nishimura, S., Numa, S., Melzer, W., Feldmeyer, D., Pohl, B., Zöllner, P., Müller, T. H., Swandulla, D., Misgeld, U, Ganitkevich, V. Ya., Isenberg, G., Cavalié, A., Allen, T. J. A., Trautwein, W., Pelzer, Siegried, Shuba, Yaroslav M., Asai, Tatsuya, Trautwein, Wolfgang, Brown, Arthur M., Birnbauner, Lutz, McDonald, Terence F., Pelzer, Dieter, Eckert, R., Hescheler, J., Rosenthal, W., Offermann, S., Krautwurst, D., Schultz, G., Kettenmahn, Helmut, Trotter, J., Verkhratsky, Alexe J N., Savtchenko, Alexej N., Verkhratsky, Alexej N., Schiefer, A., Klöckner, U., Partridge, L. D., SchÄfer, S., Jonas, P., Koh, D. S., Kampe, K., Hermsteiner, M., Vogel, W., Bauer, C. K., Schwarz, J. R., Fink, R. H. A., Wettwer, E., Weik, R., Schlatter, E., Bleich, M., Granitzer, M., Leal, T., Nagel, W., Crabbé, J., Lang, F., Kahn, E., Friedrich, F., Paulmichl, M., Hammerer, M., Maly, K., Grunicke, H., Böhm, T., Nilius, B., Gögelein, H., Dahlem, D., Weiss, H., Waldegger, S., Woell, E., Paulmichl, R., Ruppersberg, J. P., Schröter, K. H., Stocker, M., Pongs, O., Wittka, R., Boheim, G., Lichtinghagen, R, Augustine, C. K., Stühmer, W., Hoppe, Dorothe, Hoppe, D., Zittlau, K. E., Walther, C., Hatt, H., Franke, C., Quasthoff, S., Wischmeyer, E., Jockusch, H., Friedrich, M., Benndorf, K., Bollmann, G., Hirche, Hj., Hollunder-Reese, F., Mohrmann, M., Greger, R., Weber-Schürholz, S., Schürholz, T., Akabas, M., Landry, D., Al-Awqati, Q., Guse, A. H., Gercken, G., Meyerhof, W., Westphale, H. -J., Kerstins, U., Oberleithner, H., Tilmann, M., Kunzelmann, K., Klitsch, T., Siemen, D., Draguhn, A., Verdoorn, T. A., Pritchett, D. B., Seeburg, P. H., Malherbe, P., Möhler, H., Sakmann, B., Hatt, H., Dudel, J., Stern, P., Zufall, F., Rosenheimer, J., Smith, D. O., Dörner, R., Ballanyi, K., Schlue, W. -R., Kalthof, B., Pott, L., Busch, C., Konno, T., Stenql, M., Reinhardt, Ch., Kaiser, H., Baumann, R., Wilimzig, M., Eichenlaub, R., Neumann, E., Lessmann, V., Gottmann, K., Dietzel, I. D., Keller, B. U., Yaari, Y., Konnerth, A., Backus, K. H., Giller, T., Knoflach, F., Pflimlin, P., Trübe, G., von Blankenfeld, G., Ymer, S., Sontheimer, H., Ewert, M., Seeburg, P. H., Kettenmann, H., Schneggenburger, R., Paschke, D., Hülser, D. F., Ubl, J., Kolb, H. A., Ströttchen, J., Boheim, S., Wehner, F., Guth, D., Kinne, R. K. H., Hülser, D. F., Polder, H. R., Bödeker, D., Hoppe, Susanne, Höller, H., Hampe, W., Ruf, H., Schulz, I., Dehlinger-Kremer, M., Ozawa, T., Vasilets, L., Schmalzing, G., MÄdefessel, K., Biel, H., Schwarz, W., Burckhardt, B. C., Stallmach, N., MairbÄurl, H., Hoffman, J. F., Schömig, E., Heuner, A., Göbel, B. O., Siffert, W., Butke, A., Hoffmann, G., zu Brickwedde, M. -K. Meyer, Vetter, H., Düsing, R., Rosskopf, D., Osswald, U., Steffgen, J., Koepsell, H., Martens, H., Rübbelke, M., GÄbel, G., Arens, J., Stabel, J., Fischer, Y., Thomas, J., Rose, H., Kammermeier, H., Munsch, Thomas, Deitmer, Joachim W., Engelmann, B., Duhm, J., Deitmer, Joachim W., Gunzel, D., Galler, S., Fischer, H., Clauss, W., Van Driessche, W., Köckerling, A, Schulzke, JD, Sorgenfrei, D, Fromm, M, Simon, B., Ganapathy, V., Leibach, F. H., Burckhardt, G., Krattenmacher, R., Voigt, Rosita, Dietrich, S., Leyssens, A., Zhang, S. L., Weltens, R., Steels, P., Hoffmann, B., Heinz, M., Habura, B., Dörge, A., Rechkemmer, G., von Engelhardt, W., StrauB, O., Wiederholt, M., Margineanu, D. -G., Van Driessche, W., Kreusel, K. M., Fromm, M., Lempart, U., Sorgenfrei, D., Hegel, U., Augustin, A. J., . Goldstein, R., Purucker, E., Lutz, J., Illek, B., Thiele, K -P., Schwealer, JS., Dittmer, J., Bauer, C., Eckardt, K. -U., Dittmer, J., Neumann, R., Bauer, C., Kurtz, A., Fromm, H., Schulzke, J. D., Clausen, P., Krohn, A., Lüderitz, S., Hierholzer, K., Kersting, U., Woinowski, L., Gro\mann, R., Bin, X. U., Ellendorff, F., Nitschke, R., Fröbe, U., Scholz, H., della Bruna, R., Ehmke, H., Persson, P. B., Seyfarth, M., Kirchheim, H. R., Dietrich, M. S., Parekh, N., Steinhausen, M., Bührle, C. P., Nobiling, R., Ullrich, K. J., Rumrich, G., Klöss, S., Papavassiliou, F., Hoyer, J., Schmitt, C., Jungwirth, A., Ritter, M., Westphale, H. J., Bevan, C., Theiss, C., Denek, Liliana, Schwegler, Johann S., SchÄfer, Roland, Augustin, Albert J., Heidland, August, Nafz, B., Just, A., Steidl, M., Pinggera, G., Gerstberger, R., Schütz, H., Simon, E., Lohrmann, E., Masereel, B., Delarge, J., Lang, H. J., Englert, H. C., Caliebe, D., Mályusz, M., Wrigge, P., Gronow, G., Klause, N., Mályusz, M., Zinnert, H., Fagel, H., Jelkmann, W., Weiss, Ch., Augustin, A. J., Keil, R., Schmidt, W., Kröger, C., Brabant, E. G., Hilgendorf, A., Strauch, S., Lane, F., Prick, A., Golenhofen, N., Mildenberger, S., Schwegler, J. S., Flemming, B., Roloff, D., Wronski, T., Drews, G., Debuyser, A., Henquin, J. C., Jackson, M. B., DeRiemer, S. A., Schmid, A., Schnefel, S., Pröfrock, A., Hinsch, K. -D., Milz, J., Lamprecht, G., Seidler, U., Silen, W., Aziz, O., Reschke, W., Fischer, G., De Decker, N., Hayes, T., Coast, G., Van Kerkhove, E., von zur Mühlen, F., Eckstein, F., Hegel, U, Bentzel, CJ, Riecken, EO, Siemer, C., Rothenpieler, P., Smith, E., Lutnicki, K. R., Wróbel, J. T., Ledwożyw, A., PietraŚ, E., Sender, S., Jürgens, Klaus D., Kleinschmidt, T., Werkmeister, F., Kiwull-Schöne, H., Kiwull, P., Vahle, J., Ott, M., Zimmermann, R. E., Elsing, J. G., Million, D., Zillner, P., Thiel, M., Bardenheuer, H., Peter, K., Fandrey, J., Siegers, C. P., Rupp, H., Elimban, V., Dhalla, N. S., Morano, I., Agostini, B., Mühleisen, M., Mommaerts, W. F. H. M., Ono, K., Wussling, M., Schenk, W., Boldt, W., Lipp, P., Schüttler, K., Szymanski, G., Wendt-Gallitelli, M. F., Herzig, J. W., Depersin, H., Grupp, G., Grupp, I., Glitsch, H. G., Pusch, H., Zylka, Ch., Brāndle, M., Jacob, R., Stein, T., Isselhard, W., Sturz, J., Minor, T., Wingenfeld, P., Siegmund, B., Klietz, T., Schwartz, P., Piper, H. M., Linder, Christa, SchÄfer, Stefan, Heusch, Gerd, Becker, B. F., Reinholz, N., Raschke, P., Leipert, B., Gerlach, E., Dierberger, B., Gülch, R. W., Leverkus, M., Mitsuiye, T., Pohl, U., Wang, S. Y., Meyer, R., Haas, H. G., Christmann, H. Ph, Dörner, Th, Hock, D., Hertel, R., Gagelmann, M., Forssmann, W. G., Leijendekker, W. J., Kissling, G., Michel, H., Goetz, A., Freya, M., Fleckenstein-Grün, G., Schipke, Jochen D., Harasawa, Yasuhiko, Sugiura, Seiryo, Alexander, Joe, Burkhoff, Daniel, Kling, L., Müller-Beckmann, B., Schroth, M., Sponer, G., Böhm, E., Strein, K., Dorszewski, A., Arnold, G., Pike, G. K., Bryant, D. J., Roberts, M. L., Fink, R. H., Ross, Ch., Skyschally, A., Schulz, R., Linder, C., Heusch, G., Schipke, J. D., Burkhoff, D., Alexander, J., Gollnick, F., Peter, Kh., Franken-Weyers, R., Borst, M. M., Deussen, A., Pöpping, S., Hose, H., Strotmann, K. H., Lukascek, B., Karnath, T., Güttier, K., Klaus, W., Haverkampf, K., Guhlmann, M., Schmidt-Ott, S., Heuschen, U., Mall, G., Pfitzer, G., Rösch, J., Arner, A., Rüegg, J. C., Kröger, K., Schipke, J. D., ThÄmer, V., Ehring, Thomas, ThÄmer, Volker, Guth, B. D., Schnabel, Ph A., Schmiedl, A., Gebhard, M. M., Richter, J., Bretschneider, H. J., Guth, B. D., Oudiz, R. J., Schnabel, Ph., Richter, J ., Watanabe, H., Spahr, R., Piper, H. M., Obst, O., Mertens, H., Mülsch, A., Busse, R., Lamontagne, D., Herlan, K., Huang, A., Bassenae, E., Mackert, J. R. L., Schilling, L., Parsons, A. A., Wahl, M., Hock, D., Christmann, M. Ph., Thimm, F., Frey, M., Fleckenstein, a. A., Theilen, H., Göbel, U., Kuschinsky, W., Elbert, Th., Tafil-Klawe, M., Rau, H., Lutzenberger, W., Fleckenstein, A., Forst, H., Haller, M., Santjohanser, C., Lauterjung, L., Smieško, Y., Lang, D. J., Johnson, P. C., Schröck, H., Rau, H., Elbert, T., Geiger, B, Lutzenberger, W., Koch, G., Koralewski, H. E., Perschel, F. H., Wagner, K., Krüger, U., Albrecht, M., Hohlbach, G., Maassen, N., Foerster, M., Mühling, J., Bari, F., Pleschka, K., Schmidt, H. D., Gro\, H., Loock, W., Stick, C., Diefenbacher, U., Gronewold, D., Tobinsky, M., Walther-Behrends, A., Witzleb, E., Brummermann, M., Reinertsen, R. E., Rogausch, H., Rohn, W. M., Acker, H., Delpiano, M., Dufau, E., Hentschel, J., Heller, H., Schuster, K. -D., Siekmeier, R., Kronenberger, H., Lintl, H., Schiller-Scotland, Ch. F., Gebhart, J., Heyder, J., Meier-Sydow, J., Stahlhofen, W., Mottaghy, K., Geisen, C., Richter, W., Beckman, J., Marek, W., Ulmer, W. T., Thiele, A. E., Raschke, F., Peter, J. H., Hildebrandt, G., Kullmer, T., Kozianka-Burghof, G., Thiele, A. E., Schlaefke, M. E., Gnuschke, H., Schaefer, T., Schaefer, D., Schaefer, C., Bradley, Ronald J., Sterz, Raimund, Peper, Klaus, Benterbusch, R., Kraft, Th., Yu, L. C., Kuhn, H. J., Blankenbach, K., Asmussen, G., Kunze, I., Pieper, K. -S., Steinmetz, J., Schmidt, H., Krippeit-Drews, P., Hübschen, U., Nacimiento, A. C., Günzel, D., Rathmayer, W., Gaunitz, U., Költgen, D., Zachar, E., Soltau, B., De Martino, L., Hasselbach, W., Kössler, F., Lange, P., Küchler, G., Zeugner, C., Van Eyk, J., Hodges, R. S., Lorkovic, H., Clemens, N., Scheid, P., Noack, Th., Deitmer, P., Golenhofen, K., Lammel, E., Welling, Andrea, Felbel, Jochen, Hofmann, Franz, Katoch, S., Watanabe, T., Mandrek, K., Milenov, K., Hammer, K., Rössler, W., Sann, H., Pierau, Fr -K., Nguyen-Duong, H., Schneider, P., Stahl, F., Lepple-Wienhues, A., Korbmacher, C., Haller, H., Gebauer, M., Willner, U., Bialojan, C., Lengsfeld, M., Kyrtatas, V., Dartsch, Peter C., Boels, P. J., Fischer, W., Lenz, T., Thei\, U., Kreye, V. A. W., Ohkubo, T., Kupp, H., Vonderlage, M., Schreiner, V., Dorlöchter, M., Brinkers, M., Irintchev, A., Wernig, A., Langenfeld, B., Finger, W., Wolburg, H., Beer, A., Schwejda, Ch., Scheller, D., Heister, U., Tegtmeier, F., Knöpfel, Thomas, Spuler, Andreas, Grafe, Peter, GÄhwiler, Beat, Bijak, M., Misgeld, U., Müller, W., Rausche, G., Leweke, F M., Bingmann, D., Moraidis, I., Speckmann, E. -J., Madeja, M., Mu\hoff, U., Lehmenkühler, A, Kuhlmann, D., Hans, M., Lux, H. D., StrÄub, H., Waiden, J., Baker, R. E., Grantyn, R., Perouansky, M., Kraszewski, K, Lehmenkühler, Chr, Dodt, H. U., ZieglgÄnsberger, W., Pawelzik, H., ZieglgÄngsberger, W., Mann, K., Wiethölter, H., Albrecht, D., Dreier, J., Ficker, E., Beck, H., Corrette, B J., Dreyer, F., Repp, H., Dreessen, J., Augustine, G. J., Lehmenkühler, A., Büsselberg, D., Heimrich, B., Haas, H. L., Birnstiel, S., Haas, H. L., Schönrock, B., Altrup, U., Reith, H., Speckmann, E. -J., Alzheimer, C., Bruagencate, G. ten, Fruhstorfer, B., Mignot, E., Nishino, S., Dement, W. C., Guilleminault, C., Simon-Oppermann, Christa, Günther, Olaf, Stehle, J., Reuss, S., Seidel, A., Riemann, R., Vollrath, L., Reimer, Susanne, HölIt, Volker, Sonnhof, U., Krupp, J., Claus, H, Hinckel, P., Dick, H. B. H., Hiemke, C., Jussofie, A., Dorn, T., Uhlig, S., Witte, O. W., Bother, B., Eiselt, M., Witte, H., Zwiener, ö, Rother, M, Eiseit, H., Taghavy, A., KrÄtzer, A., Clusmann, H., Heinemann, U., Block, F., Sonatg, K. -H., Falkeristein, M., Hohnsbein, J., Hoormann, J., Frieling, A., Tarkka, I. M., Kullmann, W., Bromm, B., Hirsch, M. Chr, Wissing, H., Braun, H. A., Igelmund, P., Klu\mann, F. W., Ehrenstein, W. H., Yakimoff, N., Mateeff, S., Zeise, M. L., Arriagada, J., Teschemacher, A., ZieglgÄnsberger, W., Pöppelmann, T., Köhling, R., Boerrigter, P., Reith, H., Anders, K., Ohndorf, W., Dermietzel, R., Richter, D. W., Tölle, T. R., Castro-Lopes, J. M., Neuropharmakologie, Klinische, Sandkühler, J., Leah, J. D., Herdegen, T., Zimmermann, M., Vaitl, D., Gnippe, H., Herbert, M. K., Mengel, M. K. C., Kniffki, K. -D., Linke, R., Vahle-Hinz, C., Schenda, J., Matsumura, K., Herdegen, T., fu, Q. -G., Forster, C., Hutchison, W. D., Morton, C. R., Aschoff, J., Wilhelm, Z., Schwarzacher, S. W., Wasserschaff, M, Hörner, M., Kümmel, H., Windhorst, U., Feldman, J. L., Schmid, K., Foutz, A. S., Denavit-Saubié, M., Pak, M. A., Wehling, P., Evans, C., Bandara, G., Awiszus, F., Feistner, H., Heinze, H. -J., Illert, M., Wasserschaff, M., Kleinebeckel, D., Böhmer, G., Schauer, W., Abel, H. -H., Klü\endorf, D., Koepchen, H. P., Jarolimek, W, König, St, Czachurski, J., Seller, H., Meckler, R. L., McLachlan, E. M., Boczek-Funcke, A., HÄbler, H. -J., JÄnig, W., Michaelis, M., Dembowsky, K., Königr, S., Rau, Harald, HÄbler, H. -J., Unger, M., Merker, G., Roth, J., Zeisberger, E., Gao, H., Hunold, M., Kirchner, F., Takano, K., Schulze, K., Pokorski, M., Sakakibara, Y., Masuda, A., Morikawa, T., Ahn, B., Takaishi, S., Paulev, P. -E., Honda, Y., Flügge, G., Fuchs, E., König, S., Eysel, U. Th., Schmidt-Kastner, R., Skrandies, W., Geib, T., Baumann, C., Schmidt, K. -F., Knapp, A. G., Dowling, J. E., Kuba, M., Toyonaga, N., Kubová, Z., Ehrenstein, W. H., Jacobi, P., Schmidt, K. -F., Nöll, G. N., Baumann, Ch., Tabata, M., Martin, Ch., Meissl, H., Knottenberg, Th., Scheibner, H., Zenner, Hans P., Zimmennann, Ulrike, Gitter, Alfred H., Ding, D., Smolders, J. W. T., Klinke, R., Boekhoff, I., Raming, K., Krieger, J., Tareilus, E., Strotinann, J., Breer, H., Schild, D., DeSimone, J. A., Hellwig, S., Gitter, A. H., Plinkert, P. K., Zenner, H. P., Koltzenbwg, M., Pinter, E., SchÄfer, K., Braun, H. A., Necker, R., Hanesch, U., Heppelmann, B., Schmidt, R. F., Mense, S., Hoheisel, U., Steen, K. H., Anton, F., Reek, P. W., Handwerker, H. O., Lewin, G. R., McMahon, S. B., Heyer, G., Hornstein, O. P., Klement, W., Arndt, J. O., Maeerl, W., GrÄmer, G., Schepelmann, K., Me\linger, K., Schaible, H. -G., Treede, R. D., Meyer, R. A., Campbell, J. N., Claus, D., Neundörfer, B., Ernst, R., Tick-Waider, A. M., Bretschneider, F., Peters, R. C., Tennis, P. F. M., Teunis, P. F. M., Hoheisel, D., Scherotzke, R., Bub, A., Manzl, G., Forssmann, W. G., Jessen, C., Nuesslein, B., Schmidt, I., Wetzig, J., Reiser, M., Bregenzer, N., von Baumgarten, R. J., Mohr, E., Krzywanek, H., Warncke, G., Schuchmann, K. -L., Linow, H., Klu\mann, F. H., Redlin, U., Heldmaier, G., Bamler, A, Koller, A., Felber, S., Haid, C., Wicke, K., Raas, E., Xuemin, Wang, Kerning, Chen, Ying, Shi, Hanping, Shi, Warncke, Günther, Voisord, R., Dortsch, P. C., Betz, E., Karbach, U., Walenta, S., Gross, M. W., Mueller-Klieser, W., Vaupel, P., Okunieff, P., Mayer, W. -K., Stohrer, M., Krüger, W., Müller-Klieser, W., Strupp, M., Weial, P., Bostock, H., Piwernetz, K., Renner, R., Grafe, P., Lankers, J., Zangemeister, W., Kunze, K., Tries, S., Heinle, H., Beckerath, N. V., Maier-Rudolph, W., Mehrke, G., Günther, K., Goedel-Meinen, L., Daut, J., Piper, H. M., Kopp, A., Noll, T., Goellner, A., Gerlach, S., Teutsch, H. F., Schienger, K., Schwab, R., Höckel, M., Fotev, Z., Nienhaus, M., Kaczmarczyk, Gabriele, Richter, Dinah, Korte, Gabriele, Förther, J., Reinhardt, H. W., Schreiber, R., Rupp, J., Murphy, G., Fingerle, J., Kloiber, O., Miyazawa, T., Höhn-Berlage, M., Hossmann, K. -A., Schad, H., Heimisch, W., Blasini, R., Haas, F., Mendier, M., Spuler, A., Lehmann-Hom, F., Wolfram, U., Fenske, M., Sachser, N., Weis, Ch., Marktl, W., Kopta, B., Klammer, N., Rudas, B., Pohl, H., Nienartowicz, A., Moll, W., Klempt, M., Blum, S., Bühler, H., Lichtenstein, I., Novak, A., Siebe, H., Hierholzer, K., and Peper, K.
- Published
- 1990
- Full Text
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7. Fast desensitization of glutamate activated AMPAkainate receptors in rat thalamic neurones
- Author
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Leßmann, V. and Gottmann, K.
- Abstract
An essential part of the excitatory afferent input to the thalamus is mediated by glutamate receptors of the AMPA/kainate type. In contrast to other regions of the mammalian CNS, the biophysical properties of these receptors have not been investigated in thalamic neurones. Using a fast transmitter application system we studied L-glutamate activated currents of cultured neurones in the whole cell and outside-out patch configuration. Current–voltage relationships and dose–response curves of whole cell recordings were in close correspondence to results obtained from other brain areas. Analysis of outside-out patch currents revealed two types of desensitization time constants of 3.0 and 10.2 ms, with the former close to the time constant of decay of miniature glutamatergic synaptic currents.
- Published
- 1994
8. Modulation of unitary glutamatergic synapses by neurotrophin-4/5 or brain-derived neurotrophic factor in hippocampal microcultures: presynaptic enhancement depends on pre-established paired-pulse facilitation
- Author
-
Lessmann, V. and Heumann, R.
- Published
- 1998
- Full Text
- View/download PDF
9. Enhancement of postsynaptic serotonin-activated Cl− currents by depolarization-induced Ca2+ entry into leech neurons
- Author
-
Lessmann, V. and Dietzel, I.D.
- Abstract
Postsynaptic Ca2+ signals are a precondition for many types of synapse modification, including long-term potentiation. Here we describe a postsynaptic mechanism that augments synaptic currents at the serotonergic Retzius-P cell synapse of the leech. Depolarizations large enough to elicit Ca2+ currents evoked an increase in the amplitude of serotonin-activated Cl− currents in isolated embryonic neurons as well as at the Retzius-P cell synapse. The effect on embryonic whole cell currents lasted for up to one hour and was abolished in solutions containing Cd2+ as a Ca2+ channel blocker. Hence, Ca2+ influx into the postsynaptic neuron may be a common step regulating the plasticity of various vertebrate as well as invertebrate synapses.
- Published
- 1995
- Full Text
- View/download PDF
10. Neurotrophin-dependent modulation of glutamatergic synaptic transmission in the mammalian CNS
- Author
-
Lessmann, V.
- Published
- 1998
- Full Text
- View/download PDF
11. Evans blue reduces macroscopic desensitization of non-NMDA receptor mediated currents and prolongs excitatory postsynaptic currents in cultured rat thalamic neurons
- Author
-
Lessmann, V., Gottmann, K., and Lux, H. D.
- Published
- 1992
- Full Text
- View/download PDF
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