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Feasibility studies of various architectural projects lead to an analysis of planar configurations possessing a maximal number of adjacent-relations. This work extends current understanding of the properties of such configurations and describes a method for their creation. In practice, only those figures which meet the preconditions and expectations (with respect to adjacency-relations) are useful. In conclusion, a way of constructing these configurations is shown and the maximal number of different forms is established.

This paper is a description of a model of building systems in architecture. The general aim of this paper is to show how a construction system can be analyzed and planned by the help of rules derived from the topological and geometrical properties of its elements. First are presented some general problems which arise in construction from prefabricated elements. Because orthogonal construction systems are used most frequently, consideration is confined to these. More concretely, a model is constructed which represents feasible construction systems; the construction rules of this model are generalizable to other orthogonal systems.The model is built up from square slabs of four kinds. All possible different cells generated by the slabs are obtained and the cells are put together totally filling the space in a compact way. Because of the importance of building systems which have only a few kind of elements or connecting parts, consideration is restricted to cell systems with only one kind of slab.

Purpose: To determine the dose response of low-dose oral naltrexone (NTX) on the analgesia produced from 10 mg of hydrocodone (HYIR) in healthy subjects with thermally induced hyperalgesia.Methods: Subjects first received a thermal discomfort test to determine hyperalgesic response and their responsiveness to opioid analgesic effects. Subjects who qualified entered a 5-treatment, 5-period crossover, double-blind phase in which they received placebo HYIR plus placebo NTX, HYIR plus placebo, or HYIR + 0.125, 0.250, or 0.500 mg of NTX.Results: A suggested dose response was observed among the NTX doses on reducing thermal discomfort scores. Mean values among the different doses of NTX in thermal discomfort scores did not reveal any clinically relevant differences. Other measures of opioid effects such as 'drug liking' and 'feel the drug' revealed no differences among NTX doses. Observed adverse events were those commonly associated with opioids.Conclusion: Increasing doses of naltrexone appear to slightly attenuate the analgesia from hydocodone; however, the effects do not appear to be relevant in this model.Clinical Pharmacology & Therapeutics (2004) 75, P71–P71; doi: 10.1016/j.clpt.2003.11.268