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A rapid Brønsted superbase catalysis for highly functionalized sulfur(VI)–fluoride exchange (SuFEx) hubs bearing all-carbon quaternary centers was developed. Remarkable functional group tolerance toward esters and nitriles was achieved by Michael addition of cyanoacetate derivatives to ethenesulfonyl fluoride with low catalyst loadings (∼0.5 mol %) within a short reaction time (0.5–30 min). Gram-scalability, water tolerance, and compatibility in polymeric catalysis showcase its unique practicability. SuFEx click conjugations were demonstrated using various amines, including DNA-tethered biomolecules.

IMPORTANCE: The discovery of the anti-GQ1b antibody has expanded the nosology of classic Miller Fisher syndrome to include Bickerstaff brainstem encephalitis, Guillain-Barré syndrome with ophthalmoplegia, and acute ophthalmoplegia without ataxia, which have been brought under the umbrella term anti-GQ1b antibody syndrome. It seems timely to define the phenotypes of anti-GQ1b antibody syndrome for the proper diagnosis of this syndrome with diverse clinical presentations. This review summarizes these syndromes and introduces recently identified subtypes. OBSERVATIONS: Although ophthalmoplegia is a hallmark of anti-GQ1b antibody syndrome, recent studies have identified this antibody in patients with acute vestibular syndrome, optic neuropathy with disc swelling, and acute sensory ataxic neuropathy of atypical presentation. Ophthalmoplegia associated with anti-GQ1b antibody positivity is complete in more than half of the patients but may be monocular or comitant. The prognosis is mostly favorable; however, approximately 14% of patients experience relapse. CONCLUSIONS AND RELEVANCE: Anti-GQ1b antibody syndrome may present diverse neurological manifestations, including ophthalmoplegia, ataxia, areflexia, central or peripheral vestibulopathy, and optic neuropathy. Understanding the wide clinical spectrum may aid in the differentiation and management of immune-mediated neuropathies with multiple presentations.

Volumetric muscle loss (VML) frequently results from traumatic incidents and can lead to severe functional disabilities. Hydrogels have been widely employed for VML tissue regeneration, which are unfortunately ineffective because of the lack of intimate contact with injured tissue for structural and mechanical support. Adhesive hydrogels allow for strong tissue connections for wound closure. Nevertheless, conventional adhesive hydrogels exhibit poor tissue adhesion in moist, bleeding wounds due to the hydration layer at the tissue–hydrogel interfaces, resulting in insufficient performance. In this study, we developed a novel, biocompatible, wet tissue adhesive powder hydrogel consisting of dextran-aldehyde (dex-ald) and gelatin for the regeneration of VML. This powder absorbs the interfacial tissue fluid and buffer solution on the tissue, spontaneously forms a hydrogel, and strongly adheres to the tissue via various molecular interactions, including the Schiff base reaction. In particular, the powder composition with a 1:4 ratio of dex-ald to gelatin exhibited optimal characteristics with an appropriate gelation time (258 s), strong tissue adhesion (14.5 kPa), and stability. Dex-ald/gelatin powder hydrogels presented strong adhesion to various organs and excellent hemostasis compared to other wet hydrogels and fibrin glue. A mouse VML injury model revealed that the dex-ald/gelatin powder hydrogel significantly improved muscle regeneration, reduced fibrosis, enhanced vascularization, and decreased inflammation. Consequently, our wet-adhesive powder hydrogel can serve as an effective platform for repairing various tissues, including the heart, muscle, and nerve tissues.

The organic molecular 2,2′,7,7′-tetrakis(4,4′-dimethoxy-3-methyldiphenylamino)-9,9′-spirobifluorene (Spiro-MeOTAD) is known as a typical hole transport material in the development of an all-solid-state perovskite solar cell (PSC). Spiro-MeOTAD requires additives of lithium bifurflimide (LiTFSI) and 4-tert-butylpyridine (tBP) to increase the conductivity and solubility for enhancing the photovoltaic performance of PSCs. However, those additives have an adverse effect on the thermal stability. We report on the origin of instability of additive-containing Spiro-MeOTAD at 85 °C and the methodology to solve the thermal instability. We have found that the interaction of LiTFSI with the underneath perovskite surface facilitated by diffusive tBP is responsible for thermal degradation. Degasification of tBP from the Spiro-MeOTAD film is found to be the key to achieving thermally stable PSCs, where the optimal degassing process achieves 90% of the initial power conversion efficiency (PCE) at 85 °C after 1000 h.

Despite the advancement of the Internet of Things (IoT) and portable devices, the development of zero-biased sensing systems for the dual detection of light and gases remains a challenge. As an emerging technology, direct energy conversion driven by intriguing physical properties of two-dimensional (2D) materials can be realized in nanodevices or a zero-biased integrated system. In this study, we unprecedentedly attempted to exploit the photostimulated pyrothermoelectric coupling of two-dimensional SnSe for use in zero-biased multimodal transducers for the dual detection of light and gases. We synthesized homogeneous, large-area 6 in SnSe multilayers via a rational synthetic route based on the thermal decomposition of a solution-processed single-source precursor. Zero-biased SnSe transducers for the dual monitoring of light and gases were realized by exploiting the synergistic coupling of the photostimulated pyroelectric and thermoelectric effects of SnSe. The extracted photoresponsivity at 532 nm and NO2gas responsivity of the SnSe-based transducers corresponded to 1.07 × 10–6A/W and 13263.6% at 0 V, respectively. To bring universal applicability of the zero-biased SnSe transducers, the wide operation bandwidth photoelectrical properties (visible to NIR) and dynamic current responses toward two NO2/NH3gases were systematically evaluated.

This paper reports chemiresistive multiarray gas sensors through the synthesized ternary nanocomposites, using a one-pot method to integrate two-dimensional MXene (Ti3C2Tx) with Ti-doped WO3(Ti-WO3/Ti3C2Tx) and Ti3C2Txwith Pd-doped SnO2(Pd-SnO2/Ti3C2Tx). The gas sensors based on Ti-WO3/Ti3C2Txand Pd-SnO2/Ti3C2Txexhibit exceptional sensitivity, particularly in detecting 70% at 1 ppm acetone and 91.1% at 1 ppm of H2S. Notably, our sensors demonstrate a remarkable sensing performance in the low-ppb range for acetone and H2S. Specifically, the Ti-WO3/Ti3C2Txsensor demonstrates a detection limit of 0.035 ppb for acetone, and the Pd-SnO2/Ti3C2Txsensor shows 0.116 ppb for H2S. Simultaneous measurements with Ti-WO3/Ti3C2Tx- and Pd-SnO2/Ti3C2Tx-based sensors enable the evaluation of both the concentration and type of unknown target gases, such as acetone or H2S. Furthermore, density functional theory calculations are performed to clarify the role of Ti and Pd doping in enhancing the performance of Ti-WO3/Ti3C2Txand Pd-SnO2/Ti3C2Txnanocomposites. Theoretical simulations contribute to a deeper understanding of the doping effects, providing essential insights into the mechanisms underlying the enhanced gas response of the gas sensors. Overall, this work provides valuable insights into the gas-sensing mechanisms and introduces a novel approach for high-performance multiarray gas sensing.

Perovskite solar cells (PSCs) have demonstrated a comparable efficiency to Si-based cells. However, the buried interface with weak adhesion remains a critical issue since the ion migration enhanced by the built-in electric field at this interface might lead to instability. We report here that adjusting the energy-level alignment at the weak adhesion homojunction interface can mitigate ion migration and thereby enhance the stability and photovoltaic performance of PSCs. Functional molecules with self-assembled monolayer characteristics were introduced to the surface of the SnO2layer using silane derivatives, which tuned the work function of the homojunction depending on the functional groups in the molecules and thereby significantly reduced the built-in electric field. The PSC exhibited a power conversion efficiency (PCE) of 25.3%. The maximum power point (MPP) tracking under continuous illumination confirmed that the device retained more than 97% of its initial PCE, even after 1,000 h.

In-vitromeat production has entered into the phase of pilot-commercial scale production from the conceptual-laboratory phase. The main challenge for in-vitromeat production on a commercial scale is the very high cost of its production, mainly due to the cost of cell culture media, growth regulators, and the requirement of highly skilled manpower. The development of serum-free and animal-free culture media with plant, microbial, and fungi-derived compounds through recombinant technology and media recycling is crucial for scaling up in-vitromeat production and reducing the price of the end products. The proper design of bioreactors specific to in-vitromeat production, their automation, utilization of natural and edible scaffolds, and microcarriers made up of edible materials are the present focus of researchers. The co-culturing by proliferating various cells such as adipocytes, chondrocytes, fibroblasts, and endothelial cells are applied for imparting textural and organoleptic attributes to developed products similar to conventional meat. The industrial process to produce in-vitromeat needs a clear synergy between the biological, chemical, technical, and industrial fields because at the moment the main research focus is on the development and improvement of cell lines available to set up cell culture and culture media, bioreactors, cell lines, scaffolding, and biofabrication. The research on in-vitromeat is limited by the fact that from the industry the protocols are not properly divulgated.

In vitrovascularized cancer models utilizing microfluidics have emerged as a promising tool for mechanism study and drug screening. However, the lack of consideration and preparation methods for cancer cellular sources that are capable of adequately replicating the metastatic features of circulating tumor cells contributed to low relevancy with in vivoexperimental results. Here, we show that the properties of cancer cellular sources have a considerable impact on the validity of the in vitrometastasis model. Notably, with a hydrophobic surface, we can create highly metastatic spheroids equipped with aggressive invasion, endothelium adhesion capabilities, and activated metabolic features. Combining these metastatic spheroids with the well-constructed microfluidic-based extravasation model, we validate that these metastatic spheroids exhibited a distinct extravasation response to epidermal growth factor (EGF) and normal human lung fibroblasts compared to the 2D cultured cancer cells, which is consistent with the previously reported results of in vivoexperiments. Furthermore, the applicability of the developed model as a therapeutic screening platform for cancer extravasation is validated through profiling and inhibition of cytokines. We believe this model incorporating hydrophobic surface-cultured 3D cancer cells provides reliable experimental data in a clear and concise manner, bridging the gap between the conventional in vitromodels and in vivoexperiments.

We report the surface modification of nanochannels whose channels are formed from stacked and overlapping graphene oxide sheets, in which the high density of nitrogen/oxygen groups and networks of H bonds serve as excellent proton channels but block the transport of cations such as Li+and Na+. The membrane has excellent stability when immersed for long periods under water and has an NaCl rejection rate of approximately 99% while maintaining permeability to water and performs well for at least 400 h for desalination. Our straightforward approach to achieving this type of two-dimensional channel material for selective ion conduction, efficient ion separation, and water desalination might open a host of possible new uses.

Background: Securing a professional baseball career is a formidable task, and only a unique few can overcome the obstacles necessary to become a Major League player in the Korea Baseball Organization (KBO). When achieving a spot in a KBO Major League team, a player’s technical aspect may be influenced by their initial neuropsychological status.Hypothesis: Personality and neurocognitive functions influence long-term pro-baseball league success.Study Design: Cohort observational study.Level of Evidence: Level 3.Methods: From the start of each player’s career, we monitored the status and course of 153 baseball players in the KBO from 2009 to 2019 who agreed to participate in this study. The Korean versions of the Temperament and Character Inventory (TCI) and the State-Trait Anxiety Inventory-Y (STAI-KY) analyzed traits and estimated state and trait anxiety levels, respectively. The Trail Making Test (TMT) (parts A and B) assessed attention shifting, and, in the Wisconsin Card Sorting Test (WCST), perseverative errors determined cognitive flexibility. Hierarchical logistic regression models were used to predict player status variables, with TCI and neurocognitive function variables as covariates.Results: High novelty-seeking scores, low state anxiety, and short TMT A results reliably predict KBO Major League participation in a player’s third year. Similarly, low state anxiety scores and high harm avoidance, reward dependence, and self-transcendence scores accurately predict KBO Major League participation in a player’s fifth year. Lastly, short TMT A results, low perseverative error scores, and high novelty-seeking, harm avoidance, reward dependence, and self-transcendence efficiently predict KBO Major League participation in a player’s seventh year.Conclusion: Draft ranking, personality, and neurocognitive function are associated with pro-baseball league achievement. In particular, personality and neuropsychological functions are associated with long-term success.Clinical Relevance: Clinically, sound personality and neuropsychological functions determine KBO Major League success.

High power conversion efficiency (PCE) and mechanical robustness are dual requisites for wearable applications of organic solar cells (OSCs). Here, we simultaneously achieve high electronic and mechanical performances in OSCs using conjugated polymer donors (PDs) consisting of electroactive rigid and soft blocks. Specifically, we integrate rigid and soft blocks to synthesize block-copolymerized PDs (D180.8-s-PEHDT0.2) having an appropriate molecular weight of D18 blocks to reach the effective conjugation length and of PEHDT blocks to achieve high mechanical properties. As a result, the D180.8-s-PEHDT0.2OSCs achieve excellent PCE (19.0%) and stretchability (crack-onset strain [COS] = 17.2%), thus overcoming the trade-off between the photovoltaic and mechanical properties in D18- (PCE = 18.1% and COS = 1.5%) and PEHDT-based OSCs (PCE = 5.0% and COS = 30.7%). Consequently, the D180.8-s-PEHDT0.2-based intrinsically stretchable (IS)-OSCs achieve both a high PCE (14.3%) and excellent stretchability (preserving 80% of the initial PCE at 31% strain).

Lake surface temperatures are projected to increase under climate change, which could trigger shifts in the future distribution of thermally sensitive aquatic species. Of particular concern for lake ecosystems are when temperatures increase outside the range of natural variability, without analogue either today or in the past. However, our knowledge of when such no-analogue conditions will appear remains uncertain. Here, using daily outputs from a large ensemble of SSP3-7.0 Earth system model projections, we show that these conditions will emerge at the surface of many northern lakes under a global warming of 4.0 °C above pre-industrial conditions. No-analogue conditions will occur sooner, under 2.4 °C of warming, at lower latitudes, primarily due to a weaker range of natural variability, which increases the likelihood of the upper natural limit of lake temperature being exceeded. Similar patterns are also projected in subsurface water, with no-analogue conditions occurring first at low latitudes and occurring last, if at all, at higher latitudes. Our study suggests that global warming will induce changes across the water column, particularly at low latitudes, leading to the emergence of unparalleled climates with no modern counterparts, probably affecting their habitability and leading to rearrangements of freshwater habitats this century.

ObjectivesThis study systematically reviewed the literature on the effect of home-based supportive care (HbSC) programmes on the quality of life (QoL) of patients with advanced cancer.MethodsThe research question ‘Do home-based supportive care programmes for patients with advanced cancer improve their QoL?’ was addressed. After registering the plan with PROSPERO (CRD42022341237), literature published from 1 January 1990 to 30 May 2023 was searched on PubMed, Embase, Cochrane database, CINAHL and Web of Science, and reviewed for inclusion based on predefined criteria. This review only included trial studies published in English.ResultsOf 5,276 articles identified, 17 studies were judged suitable for inclusion in this review. The components of HbSC programmes included home visits, patient and caregiver education, home nursing, psychotherapy, exercise, telephone consultation, and multidisciplinary team meetings. Nine studies reported improvements in QoL, including social functioning, emotional functioning, and subjective QoL.ConclusionHbSC programmes appear to enable the improvement of the QoL of patients with advanced cancer. The area of QoL that shows improvement could vary depending on the HbSC components. More studies that address HbSC programmes are needed to select patients at the proper time and provide suitable programmes for patients to benefit most.

Individuals with Parkinson’s disease (PD) experience speech and voice-related symptoms that diminish communication and quality of life. Semi-occluded vocal tract (SOVT) exercises are targeted interventions that, when combined with the positive psychosocial benefits of therapeutic group singing (TGS), may affect outcomes. The purpose of this study was to explore the effectiveness of SOVT exercises, specifically straw phonation combined with TGS, to improve voice quality and mood for individuals with PD. We used a true experimental pretest–posttest between-subjects design (i.e., randomized controlled trial) facilitated by a board-certified music therapist. All participants (N= 27) were randomly assigned to one of three groups (a) straw phonation combined with TGS (SP + TGS, n= 10), (b) TGS (n= 10), and (c) speaking-only control group (n= 7). Participants completed voice recordings for acoustic measures and the Visual Analogue Mood Scale for mood analysis before and after a 30-min intervention. The results demonstrated significant improvement in voice quality evidenced by decreasing Acoustic Voice Quality Index scores following a single session for both SP + TGS and TGS intervention groups when compared to the control. Happiness scores improved in the experimental groups when compared to control. Although not statistically significant, participants in the experimental groups (SP + TGS, TGS) demonstrated better mean mood scores on happiness, anxiety, and angry when compared to control, indicating a positive psychological response to the singing interventions. Overall, this study indicated the effectiveness of SP + TGS and TGS as promising therapeutic interventions for voice quality and mood in individuals with PD.

This paper presents a new machine vision framework for the efficient examination and classification of surface textures on medium- and large-sized mold products, such as used for automobiles, TVs, and refrigerators. Existing techniques, which are based on the hands and eyes of skilled workers, are inconsistent and time-consuming. Although there are many types of precise surface inspection and measurement methods, most are difficult to apply at industrial sites or by finishing robots due to problems such as speed, setup limitations, and robustness. This paper proposes two techniques based on image processing that aims to automate surface inspection during an unmanned lapping process that is mainly employed to eliminate milling tool marks. First, both the shape of the reflected light and the intensity of the captured near-field contrast image right after the reflected specular are used to determine the machined surface state, and the presence of tool marks as the line light source scans counter-clockwise. Second, the photometric stereo technique is used to detect surface scratches through the normal map that recovers the surface. The proposed techniques show localized machined patterns and classify them with high accuracy.

This communication proposes a novel design method for a quasi-2-bit reconfigurable metasurface antenna (RMA) to improve aperture efficiency using a simple bias circuit. The quasi-2-bit RMA is designed by combining two types of 1-bit unit cells to achieve four quantized phase states, which results in quantization efficiencies similar to an ideal 2-bit for a specific direction while maintaining a simple 1-bit bias circuit. Furthermore, this RMA can also be designed for multiple beam directions by optimizing the combination of the 1-bit unit cells using the least square method. The quasi-2-bit RMA is then experimentally verified by fabricating a structure optimized for two beam switching angles of ±18° in the E-plane. The aperture efficiencies of the quasi-2-bit RMA are measured to be 25.1% for - 18° and 28.1% for 18°, respectively. Compared to 1-bit RMAs, the measured aperture efficiency of the quasi-2-bit RMA is improved by 61.49% for the - 18° beam and by 114.2% for the 18° beam, respectively.

This study examined daily affective dynamic indices among individuals with a major depressive disorder (MDD) diagnosis in the past one year at the time of the interview, focusing on affective variability and change in affect in response to daily events (affective reactivity). Data were from the main survey and daily diary project of the Midlife in the United States (MIDUS) study. Participants (N= 1,970; nMDD= 202; nnon-MDD= 1,768) completed structured clinical interviews on mental health and telephone interviews about their daily experiences spanning eight consecutive days. Multilevel models revealed that the MDD group experienced greater positive (PA) and negative affect (NA) variability than the non-MDD group. On days that at least one stressful event was reported, the MDD group experienced a greater decrease in PA and a greater increase in NA. On days that at least one positive event was reported, the MDD group experienced a greater increase in PA and a greater decrease in NA. Changes in affect to daily events, particularly the mood brightening effect, may be indicators of depression and potential targets for intervention. Limitations of the study include a community sample, reliance on self-reported measures of daily stressors and positive events, inclusion of remitted and current MDD participants, and the DSM-III-R based criteria for MDD diagnosis.

Understanding the interplay between the surface structure and the passivation materials and their effects associated with surface structure modification is of fundamental importance; however, it remains an unsolved problem in the perovskite passivation field. Here, we report a surface passivation principle for efficient perovskite solar cells via a facet-dependent passivation phenomenon. The passivation process selectively occurs on facets, which is observed with various post-treatment materials with different functionality, and the atomic arrangements of the facets determine the alignments of the passivation layers. The profound understanding of facet-dependent passivation leads to the finding of 2-amidinopyridine hydroiodide as the material for a uniform and effective passivation on both (100) and (111) facets. Consequently, we achieved perovskite solar cells with an efficiency of 25.10% and enhanced stability. The concept of facet-dependent passivation can provide an important clue on unidentified passivation principles for perovskite materials and a novel means to enhance the performance and stability of perovskite-based devices.

We present an electrochemical method to functionalize single-crystal graphene grown on copper foils with a (111) surface orientation by chemical vapor deposition (CVD). Graphene on Cu(111) is functionalized with 4-iodoaniline by applying a constant negative potential, and the degree of functionalization depends on the applied potential and reaction time. Our approach stands out from previous methods due to its transfer-free method, which enables more precise and efficient functionalization of single-crystal graphene. We report the suggested effects of the Cu substrate facet by comparing the reactivity of graphene on Cu(111) and Cu(115). The electrochemical reaction rate changes dramatically at the potential threshold for each facet. Kelvin probe force microscopy was used to measure the work function, and the difference in onset potentials of the electrochemical reaction on these two different facets are explained in terms of the difference in work function values. Density functional theory and Monte Carlo calculations were used to calculate the work function of graphene and the thermodynamic stability of the aniline functionalized graphene on these two facets. This study provides a deeper understanding of the electrochemical behavior of graphene (including single-crystal graphene) on Cu(111) and Cu(115). It also serves as a basis for further study of a broad range of reagents and thus functional groups and of the role of metal substrate beneath graphene.

Germline commitment following primordial germ cell (PGC) specification during early human development establishes an epigenetic programme and competence for gametogenesis. Here we follow the progression of nascent PGC-like cells derived from human embryonic stem cells in vitro. We show that switching from BMP signalling for PGC specification to Activin A and retinoic acid resulted in DMRT1 and CDH5 expression, the indicators of migratory PGCs in vivo. Moreover, the induction of DMRT1 and SOX17 in PGC-like cells promoted epigenetic resetting with striking global enrichment of 5-hydroxymethylcytosine and locus-specific loss of 5-methylcytosine at DMRT1 binding sites and the expression of DAZL representing DNA methylation-sensitive genes, a hallmark of the germline commitment programme. We provide insight into the unique role of DMRT1 in germline development for advances in human germ cell biology and in vitro gametogenesis.

Background: In the elderly, diagnostic findings of pneumonia are often atypical. Computed tomography was recommended for the diagnosis of pneumonia in elderly patients. Recently, the usage of computed tomography as a screening tool for pneumonia in emergency departments has increased. Sarcopenia is defined as the loss of skeletal muscle mass and strength with aging. In this study, the association between sarcopenia and prognosis measured through computed tomography was evaluated compared to CURB-65.Methods: This study was conducted on patients diagnosed with pneumonia through computed tomography from 1 March 2018 to 31 March 2020. The paraspinous muscle size and attenuation were measured at a level located at the T12 pedicle level on axial computed tomography images. Paraspinous muscle size was presented as paraspinous muscle index. Differences in the prognostic performance among the paraspinous muscle size and attenuation, and CURB-65 were evaluated by the area under the receiver operating characteristic curve.Results: A total of 509 patients were included and 132 patients (25.9%) were admitted to the ICU, and 58 patients (11.4%) died in hospital. Paraspinous muscle index was the significant factor for predicting in-hospital mortality and ICU admission. The area under the receiver operating characteristic value of paraspinous muscle index for prediction of mortality was 0.738 and CURB-65 was 0.707. The area under the receiver operating characteristic of paraspinous muscle index and CURB-65 for predicting ICU admission were 0.766 and 0.704, respectively.Conclusion: As a method of measuring sarcopenia, paraspinous muscle index was superior to CURB-65 in elderly pneumonia patients. The use of computed tomography in predicting prognosis for elderly pneumonia patients will ease the economic burden.