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A valid assessment tool that measures active play is not yet available due to the sporadic and spontaneous nature of play, as well as the potential differences in how active play is understood and measured across different age groups, cultures, and contexts. The purpose of this review was to identify the scope and gaps in the measurement of active play based on data gathered from 68 countries that participated in the Global Matrix (GM) initiative, led by the Active Healthy Kids Global Alliance (AHKGA). GM is the global-level, biennial evaluation system of physical activity related behaviors among children and youth, including the Active Play indicator, and the sources of influence using letter grades (ranging between "A" and "F"). Based on the identified scope and gaps, this study offers recommendations for future research dedicated to the measurement/surveillance of active play. Out of the 68 countries involved in the previous GM (2014–22), 55% of the grades remained unassigned due to insufficient data on the Active Play indicator. The high number of unassigned grades, combined with the absence of valid measurement tool, highlight a need for a standardized measurement tool for improved global data generation of active play among children and youth. Our findings emphasize the need to address challenges in measuring active play. This review offers future considerations, research recommendations specific to the GM initiative, and two sets of age- and location-specific (indoor and outdoor settings) questionnaire items along with guidelines for its use. Together, these elements provide a roadmap for guiding future research and evaluation efforts on active play. [ABSTRACT FROM AUTHOR]

• Less than 1% of Korean adolescents met the overall 24-h movement guidelines. • Meeting the individual and overall 24-h movement guidelines was generally low and largely gendered. • Social class manifests in different ways in conjunction with gender to shape patterns of movement behaviors. • Quantitative intersectionality is a useful statistical framework in identifying important correlates of 24-h movement behaviors. Grounded in intersectionality theory, this study examined the 6-year prevalence trend and correlates in meeting Canada's 24-Hour Movement Guidelines (Guidelines hereafter) in a nationally representative adolescent samples of South Korea (officially the Republic of Korea). Self-reported, annually repeated cross-sectional data collected between 2013 and 2018 were used (n = 372,433, 12–17 years old, 47.9% females). Adolescents were categorized as meeting or not meeting different sets of physical activity, screen time (ST), and sleep recommendations within the Guidelines, separately for weekdays and weekend days. Intersectional correlates included sex and social class (i.e., family economic status, parental education level, and academic performance). Multiple logistic regression analyses were performed. Overall, the proportion of adolescents meeting physical activity, ST, and sleep recommendations were 5.3%, 60.3%, and 10.2% on weekdays and 5.3%, 28.2%, and 46.4% on weekend days, respectively. Between 2013 and 2018, no substantial changes were observed for meeting the physical activity or sleep recommendation, while meeting the ST recommendation was markedly lower in 2018. The proportion of meeting all 3 recommendations were 0.5% for weekdays and 0.8% for weekend days. Overall, compared to female adolescents, male adolescents were consistently associated with more favorable patterns of meeting different sets of recommendations, regardless of social class. Among females only, social class appeared to be not important or even detrimental in meeting different sets of recommendations. Being male, compounded with social class, was associated with meeting the ST recommendation. Less than 1% of Korean adolescents met the overall Guidelines. Intersectionality-based analysis and intervention may be important in promoting healthy active lifestyles among South Korean adolescents. [Display omitted] [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to examine the mediating effects of clinical nurses' job crafting on organizational effectiveness based on the job demands-resources model proposed by Bakker and Demerouti (2017). Methods: The participants consisted of 393 nurses working in nursing units of a tertiary general hospital located in Cheongju region. The data, collected using questionnaire from August 9 to August 20, 2021, were analyzed using SPSS 23.0 and AMOS 27.0. Results: The goodness-of-fit (GoF) test results on the modified model (χ² = 2.7, GFI = .94, SRMR = .03, RMSEA = .06, NFI = .92, CFI = .94, TLI = .92, AGFI = .90), indicated that the GoF index satisfied the recommended level. Regarding the effects of each variable on organizational effectiveness, job crafting showed statistically significant direct (β = .48, p < .001), indirect (β = .23, p < .001), and total effects (β = .71, p < .001). Burnout showed statistically significant direct effect (β = - .17, p < .001). Work engagement showed statistically significant direct (β = .41, p < .001) and total effects (β = .41, p < .001). The factors explaining organizational effectiveness were job crafting, burnout, and work engagement, which had an explanatory power of 76.7%. Conclusion: Nurses' job crafting is an important mediating factor for enhancing the organizational effectiveness of nursing organizations. Hospitals should develop job-crafting success cases and related education and training programs as a strategy for enhancing the job crafting of nurses and, consequently organizational effectiveness. [ABSTRACT FROM AUTHOR]

With intensifying air pollutant levels and the COVID-19 pandemic, physical inactivity of South Korean children and adolescents may be threatened. Therefore, monitoring and surveillance of physical activity (PA) and relevant indicators are important for policy making pertaining to health promotion. Report Card is a third comprehensive evaluation of PA-related behaviors among and the sources of influence for South Korean children and adolescents. To provide the outcome of the South Korea's 2022 Report Card on PA for children and adolescents. Based on a variety of sources including national surveys collected pre- and during-COVID-19 and information collected from government webpages, 11 indicators were graded by a committee of experts informed by the best available evidence. Data from during-COVID-19 were available for Overall PA, Sedentary Behavior, and Sleep and considered together in generating the overall grades. Grades were assigned to behavioral indicators (Overall PA: D -; Active Transportation: B+ ; Sedentary Behavior: D ; Sleep: F) and sources of Influence (Family and Peers: C -; School: A ; Community and Environment: B -; Government: A). Organized Sport and PA, Active Play, and Physical Fitness could not be graded due to the lack of data. The results largely indicated that children and adolescents show unfavorable behavioral grades even with favorable grades observed for the sources of influence indicators. Trivial differences were observed pre- and during-pandemic for Overall PA (≥60 min of MVPA for ≥4 d/wk: 20.8% vs 19.9%) and Sleep (met age-specific recommendation: 14.1% vs 15.0%); however, a marked increase in Sedentary Behavior was observed (≤2 h/d screen time: 28.8% vs 20.1%). A stark weekday vs weekend difference was observed in sleep duration. In terms of PA related sources of influence, high accessibility to PA facilities (81.1%) and high satisfaction of neighborhood public transit (74.6%) and safety (80.7%) were well reflected in our Active Transportation grade (B+). Nonetheless, perception of green environments including outdoor air quality (44.0%), noise (39.6%) and green space (56.5%) showed lower scores, suggesting that new barriers to active lifestyles are emerging for South Korean children and adolescents. Gender differences were also observed for overall PA (≥60 min of MVPA for ≥4 d/wk: 29.1% for boys vs 11.3% for girls) and sleep (met age-specific recommendations: 17.3% for boys vs 11.4% for girls), but not for sedentary behavior (≤2 h/d screen time: 26.4% for boys and 24.9% for girls). Government and school policies/programs and the built environment are, in general, conducive to physically active lifestyles for South Korean children and adolescents; however, behavioural indicators received poor grades except for Active Transportation. A thorough evaluation of policies/programs at government, local, and school levels is needed to ensure that the efforts to have PA-enhancing infrastructure and systems are actually being translated into the behavior of children and adolescents in South Korea. Furthermore, improving PA surveillance, monitoring, and advocacy to ultimately establish healthy lifestyle patterns among children and adolescents is a top priority. [ABSTRACT FROM AUTHOR]

Physical inactivity is a persistent and worsening population health concern in Asia. Led by the Active Healthy Kids Global Alliance, Global Matrix (GM) initiative provides an opportunity to explore how regional and cultural differences across 18 Asian countries relate to physical activity (PA) participation among children and adolescents. The purpose of study was to synthesize evidence from the GM2.0 to GM4.0 (2016–2022) in Asian countries. Report Card grades on behavioral/individual and sources of influence indicators were reported from 18 Asian countries. Letter grades were converted into numerical values for quantitative analyses. Based on this, cross-sectional and longitudinal analyses were conducted to investigate patterns and trends. Qualitative evidence synthesis was performed based on Report Card grades and published papers to identify gaps and suggest future recommendations. In total, 18 countries provided grades for at least one round of GM, 12 countries provided grades for at least two rounds, and seven countries provided grades for all three GMs. Of possible grades, 72.8%, 69.2%, and 76.9% of the grades were assigned from GM 2.0 to GM 4.0, respectively. In terms of the Report Card grades, there was a slight decrease in behavioral/individual indicators from "D+" in GM 2.0 to "D-" in GM 3.0 but this reverted to "D" in GM 4.0. For the sources of influence, a "C" grade was given in all three rounds of GM. Longitudinal observation of seven Asian countries that provided grades in all three rounds of GM revealed that grades are generally stable for all indicators with some country-specific fluctuations. In future GM initiatives and research, considerations should be made to provide more accurate and rich data and to better understand contextual challenges in evaluating certain indicators such as Active Transportation, Active Play, and Physical Fitness in particular. Further, macro level factors such as socioeconomic/cultural disparities and gender-specific barriers, ideology, or climate change should also be proactively considered in future research as these factors are becoming increasingly relevant to indicators of GM and United Nation's Sustainable Development Goals. Participation from Asian countries in GM has increased over the years, which demonstrates the region's enthusiasm, capacity, and support for global PA promotion efforts. The efforts to promote a physically active lifestyle among children and adolescents should be a collective interest and priority of the Asia region based on the gaps identified in this paper. [ABSTRACT FROM AUTHOR]

Studies regarding the impact of COVID-19 on breastfeeding have mostly used single- country samples or a qualitative design. The objective of this study was to examine breastfeeding intention during pregnancy and breastfeeding behaviour among postpartum women in five countries during the COVID-19 pandemic and the associated factors. An online questionnaire survey was conducted in Thailand, the United Kingdom, South Korea, Taiwan, and Brazil from July through November 2021. The study participants included 3253 mothers within six months of birth. About 90% of participants intended to breastfeed during pregnancy and 85.7% reported breastfeeding in the past 24 h. More than half reported their breastfeeding duration being as planned or longer despite COVID-19. Multivariate logistic regression models showed that being multiparous, ever tested COVID-19 positive, and having positive breastfeeding beliefs were associated with increased odds for intention to breastfeed during pregnancy. Lower maternal educational level, being primiparous, ever tested COVID-19 positive, and experiencing food insecurity were associated with decreased odds for breastfeeding duration being as planned or longer. Vaginal birth, currently working or on maternity leave, breastfeeding beliefs, breastfeeding support from spouse/partner/friend/relative, online support groups, and in-person or telephone contact with healthcare professionals were associated with increased odds for breastfeeding duration being as planned or longer. Breastfeeding intention and behaviour remained high during the COVID-19 pandemic. Online support groups and telephone contact with health professionals were effective during the pandemic. [ABSTRACT FROM AUTHOR]

To determine the association of first, second, and third-line biologic disease-modifying antirheumatic drugs (bDMARDs) and tofacitinib with drug survival among seropositive rheumatoid arthritis (RA) patients. The study population was composed of 8,018 seropositive RA patients who were prescribed bDMARDs or tofacitinib between January 2014 and January 2019 from the Korean Health Insurance Review and Assessment Service database. First, second, and third-line choice of tumor necrosis factor inhibitors (TNFi) including etanercept, infliximab, adalimumab, and golimumab, as well as non-TNFi including tocilizumab, rituximab, tofacitinib, and abatacept were assessed. Multivariate Cox proportional hazards regression was used to determine the adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for drug failure according to bDMARD or tofacitinib choice starting from the initial prescription date. Compared to first etanercept users, patients with first tocilizumab (aHR 0.56, 95% CI 0.46–0.68), tofacitinib (aHR 0.27, 95% CI 0.18–0.42), or abatacept (aHR 0.83, 95% CI 0.69–0.99) had lower risk of drug failure. Second choice of tocilizumab (aHR 0.38, 95% CI 0.25–0.55), tofacitinib (aHR 0.23, 95% CI 0.15–0.37), or abatacept (aHR 0.54, 95% CI 0.35–0.84) was associated with lower drug failure risk compared to second etanercept users. Finally, third choice of tocilizumab (aHR 0.32, 95% CI 0.16–0.62) or tofacitinib (aHR 0.35, 95% CI 0.19–0.63) was associated with lower drug failure risk compared to third TNFi users. First and second-line tocilizumab, tofacitinib, or abatacept may lead to improved drug survival. Third-line use of tocilizumab or tofacitinib may be beneficiary in reducing drug failure risk among seropositive RA patients. [Display omitted] • First and second-line toclizumab, tofacitinib, or abatacept use was associated with lower drug failure risk among rheumatoid arthritis (RA) patients. • Third-line choices of tocilizumab or tofacitinib was associated with improved drug survival for RA patients. • RA patients may benefit from improved survival upon tocilizumab or tofacitinib use for first, second, or third-line choices. [ABSTRACT FROM AUTHOR]

This study was aimed at generating and investigating the efficacy of a novel monoclonal bispecific antibody (BsAb) for the combined inhibition of tumor necrosis factor-α (TNF-α) and CXCL10 as a treatment option for rheumatoid arthritis (RA). A novel BsAb targeting TNF-α and CXCL10 was generated by conjugating a single-chain variable fragment (scFv) of the anti-CXCL10 monoclonal antibody to the Fc region of adalimumab (ADA). The effects of the BsAb on the inflammatory response in the in vitro and in vivo development of arthritis and joint destruction were evaluated in human TNF transgenic (hTNF-Tg) mice, and K/BxN serum transfer arthritis models. The BsAb inhibited CXCL10-mediated CD8+ T cell migration. The binding affinity of the BsAb to TNF-α was comparable to that of ADA and suppressed TNF-α induced cell death and inhibited TNF-α induced ICAM-1 and VCAM-1 in RA fibroblast-like synoviocytes (FLSs). The BsAb decreased the expression of TNFSF11 and the production of IL-6 in RA-FLS cells stimulated with TNF-α and CXCL10. Treatment with the BsAb attenuated the development of arthritis in hTNF-Tg mice and suppressed LPS-induced bone erosion. In the K/BxN serum transfer model, BsAb effectively attenuated ankle swelling, synovial inflammation, cartilage damage, and bone destruction, reducing the activation of osteoclasts. The additional neutralization of TNF-α and CXCL10 from treatment with the novel BsAb was more effective than TNF-α inhibition alone in the in vitro and in vivo models of RA. Thus, the BsAb, targeting both TNF-α and CXCL10, may provide a new therapeutic opportunity for RA patients who fail to respond to the blockade of a single cytokine. [ABSTRACT FROM AUTHOR]

Objective: This study determined the prevalence of adolescents meeting the individual and combinations of the Australian 24-Hour Movement Guidelines, and their associations with the health related quality of life (HRQoL).Methods: The participants were 3096 adolescents (mean age: 12.4 years; 49% female) from wave 7 of the birth-cohort of the Longitudinal Study of Australian Children. The outcome was parent-reported HRQoL. Meeting the 24-Hour Movement Guidelines was defined as: ≥60 min/day of moderate to vigorous physical activity (MVPA), ≤2 hour/day of recreational screen time, and 9-11 hour/night of sleep. Generalised estimating equations were used to examine the associations between meeting vs. not meeting recommendations and HRQoL outcomes.Results: The prevalence of adolescents meeting all three recommendations was 2.4%, with 23% meeting two, and 57% meeting one recommendation. Meeting all three recommendations was associated with higher overall HRQoL score (β = 4.96, 95% CI: 2.54-7.38) as well as physical (β = 5.22, 95% CI: 2.61-7.83) and psychosocial (β = 4.76, 95% CI: 1.77-7.75) scores. Meeting combinations of screen time with MVPA or sleep recommendations were associated with higher scores for all HRQoL outcomes, while meeting MVPA and sleep recommendations was associated with overall HRQoL score. Compared to meeting no recommendation, meeting more recommendations was significantly and incrementally associated with higher scores for all HRQoL outcomes (ptrend<0.001).Conclusions: Overall, meeting more recommendations within the 24-Hour Movement Guidelines was associated with better HRQoL outcomes. However, only a small percentage of adolescents met all the recommendations, which underscores the need for promoting and supporting adherence to these behaviours. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to investigate the different clinical characteristics among elderly coronavirus disease 2019 (COVID-19) patients with and without mental disorders in South Korea and determine if these characteristics have an association with underlying mental disorders causing mortality.Method: A population-based comparative cohort study was conducted using the national claims database. Individuals aged ≥65 years with confirmed COVID-19 between January 1, 2020 and April 10, 2020 were assessed. The endpoints for evaluating mortality for all participants were death, 21 days after diagnosis, or April 10, 2020. The risk of mortality associated with mental disorders was estimated using Cox hazards regression.Results: We identified 814 elderly COVID-19 patients (255 [31.3%] with mental disorder and 559 [68.7%] with nonmental disorder). Individuals with mental disorders were found more likely to be older, taking antithrombotic agents, and had diabetes, hypertension, chronic obstructive lung disease, and urinary tract infections than those without mental disorders. After propensity score stratification, our study included 781 patients in each group (236 [30.2%] with mental disorder and 545 [69.8%] with nonmental disorder). The mental disorder group showed higher mortality rates than the nonmental disorder group (12.7% [30/236] versus 6.8% [37/545]). However, compared to patients without mental disorders, the hazard ratio (HR) for mortality in elderly COVID-19 patients with mental disorders was not statistically significant (HR: 1.57, 95%CI: 0.95-2.56).Conclusion: Although the association between mental disorders in elderly individuals and mortality in COVID-19 is unclear, this study suggests that elderly patients with comorbid conditions and those taking psychiatric medications might be at a higher risk of COVID-19. [ABSTRACT FROM AUTHOR]

This study examined the validity of the FitnessGram® criterion-reference cut-points for cardiorespiratory fitness (CRF) based on two samples of US adolescents (aged 12–15 years). This study also established the CRF cut-points for metabolically healthy weight status based on a recent national fitness survey for the purposes of cross-validating with pre-existing cut-points including FitnessGram. Two cross-sectional data from the 2003–2004 National Health and Nutrition Examination Survey (NHANES) (n = 378) and 2012 NHANES National Youth Fitness Survey (NNYFS) (n = 451) were used. CRF (estimated V ˙ O 2max in mL/kg/min) was estimated from a submaximal exercise test. CRF categories based on FitnessGram cut-points, a clustered cardiometabolic risk factors score and weight status were used. A series of Receiver Operating Characteristic (ROC) curve analyses were conducted to identify age- and sex-specific CRF cut-points that were optimal for metabolically healthy weight status. Based on FitnessGram cut-points, having high risk CRF, but not low risk CRF, was associated with high cardiometabolic risk (OR = 3.17, 95% CI = 1.14–8.79) and unhealthy weight status (OR = 5.81, 95% CI = 3.49–9.68). The optimal CRF cut-points for 12-13-year-olds and 14-15-year-olds were 40 and 43 mL/kg/min in males and 39 and 34 mL/kg/min in females, respectively. Compared to meeting new CRF cut-points, not meeting new CRF cut-points was associated with higher odds of showing high cardiometabolic risk (OR = 2.91, 95% CI = 1.47–5.77) and metabolically unhealthy weight status (OR = 4.47, 95% CI = 2.83–7.05). FitnessGram CRF cut-point itself has rarely been scrutinized in previous literature. Our findings provide partial support for FitnessGram based on two samples of US adolescents. CRF cut-points established in this study supports international criterion-referenced cut-points as well as FitnessGram cut-points only for males. FitnessGram should be continuously monitored and scrutinized using different samples. [ABSTRACT FROM AUTHOR]

The Naturaliste Plateau is a submarine continental ribbon rifted from the southwest Australian margin during the Early Cretaceous breakup of East Gondwana. It occupied a key position near the juncture of Greater India and the boundary between Australia and Antarctica. However, details of the Early Cretaceous evolution of the plateau are not well known because of limited data. Drilling at Site U1513 during IODP Expedition 369 recovered the first complete Lower Cretaceous succession on the eastern Naturaliste Plateau. The succession includes syn-rift volcanic rocks, Hauterivian to early Aptian volcaniclastic-rich sedimentary rocks, and Albian claystone strata. The 235-m thick volcaniclastic-rich sequence represents the missing post-breakup record in the southwest Australian rifted margin. It spans the transition from syn- to post-rift phase during the final stages of breakup between Greater India and Australia-Antarctica. We report the lithological, petrophysical, geochemical, paleontological, and paleomagnetic characteristics of the sequence, and then synthesize the results to define the Early Cretaceous depositional environment and subsidence history of the Naturaliste Plateau. From the early Hauterivian, weathered volcanic products were eroded and re-deposited locally as a volcaniclastic-rich sequence, with a major contribution from the southern Naturaliste Plateau. The depositional environment evolved from a shelf to upper bathyal condition during the Hauterivian through early Barremian with a decreasing sedimentation rate. This period is defined as a late syn-rift subsidence phase by NW-SE trending extension. After the final breakup with Greater India, the plateau remained at upper bathyal depths with little deposition until the early Aptian. Mid–lower bathyal depths inferred from the Albian claystone strata suggest that the post-rift thermal subsidence commenced during the late Aptian. This two-phase post-rift subsidence reflects the proximity or high temperature of mantle plume, possibly the Kerguelen plume, and its westward migration relative to the southwest Australian rifted margin. Unlabelled Image • Lower Cretaceous strata at IODP Site U1513 on the Naturaliste Plateau span breakup. • Volcaniclastic-rich strata have a deepening record from shelf to upper bathyal depths. • A late syn-rift phase to two-phase post-rift subsidence history is revealed. [ABSTRACT FROM AUTHOR]

Nepal's Report Card on Physical Activity for Children and Youth summarises the available evidence on ten physical activity-related indicators among Nepalese children and youth. Published scientific papers on physical activity of Nepalese children and youth (5–17 years) were searched systematically in four databases (Medline, Embase, PsycINFO, and PubMed Central) while some survey reports were manually searched. Letter grades were assigned to ten indicators (Overall Physical Activity, Organized Sport Participation, Active Play, Active Transportation, Sedentary Behaviours, Physical Fitness, Family and Peers, School, Community and Environment, and Government) by the country's report card team based on available data. Among the ten indicators, five indicators were successfully graded based on available data. Overall Physical Activity was graded as D+. Active Transportation and Family and Peers were assigned as A- and A, respectively. Community and Environment was graded as C-. The other five indicators could not be graded due to insufficient data. Though a majority of Nepalese children and youth use active modes of transport and have adequate support for physical activity from family and peers, overall participation in physical activity appears to be low. Lack of data identified with five incomplete indicators reflects the need for further research. Studies with larger sample, more rigorous study design and objective assessment of physical activity is recommended for future physical activity surveillance in Nepal. [ABSTRACT FROM AUTHOR]

HLA genes are a major genetic risk factor for myositis and myositis specific antibodies (MSAs), exhibiting unique HLA backgrounds for myositis in different ethnic groups. This is the first large scale Korean study to genotype the HLA-DRB1 and -DPB1 alleles and to examine their association with myositis and MSAs. HLA-DRB1 and HLA-DPB1 alleles and MSAs were examined in 179 patients with dermatomyositis (DM, n = 129) or polymyositis (PM, n = 50) and healthy controls (n = 800 for HLA-DRB1, n = 548 for HLA-DPB1). Associations between individual HLA alleles and myositis/MSA were examined. Bonferroni correction was applied for multiple testing comparing patients and controls. A total of 33 HLA-DRB1 and 24 HLA-DPB1 alleles were genotyped in patients and controls. MSAs were found in 67.0% of patients. Anti-MDA5 (26.8%) and anti-aminoacyl-tRNA synthetase antibodies (15.6%) were most common, followed by anti-Mi2 (9.5%) and anti-TIF1γ antibodies (8.9%). HLA-DRB1*12:02 and HLA-DRB1*14:03 were associated with DM and PM, respectively. HLA-DRB1*12:02 was associated with anti-MDA5, HLA-DRB1*08:03 with anti-ARS, HLA-DRB1*14:03 with anti-SRP, and HLA-DRB1*07:01 with anti-Mi2 antibodies. Although HLA-DRB1*13:01 was associated with anti-TIF1γ antibodies, the frequency of HLA-DRB1*13:01 was rare. HLA-DPB1*02:01 was negatively associated with myositis and PM while HLA-DPB1*17:01 was associated with anti-Mi2 positive DM. Unique immunogenetic background was observed for Korean patients with myositis. Novel myositis susceptibility alleles, HLA-DRB1*12:02 and HLA-DRB1*14:03, were identified, together with MSA-associated HLA alleles unique to Korean patients with myositis. [ABSTRACT FROM AUTHOR]

This study aimed to examine the levels and correlates of 24-h movement behaviors (i.e., physical activity, sedentary time, and sleep), and different patterns of these behaviors in a nationally representative sample of South Koreans aged 12 years and older. This study also aimed to examine the sociodemographic correlates of 24-h movement behaviors stratified by age groups. Self-reported, repeated cross-sectional data from 10,708 participants in the 2014 and 2015 Korea National Health and Nutrition Examination surveys were used. Key variables included moderate-to-vigorous intensity physical activity, muscular strengthening exercises, walking, active transportation, sedentary time, and sleep. Sociodemographic variables included age, sex, household income, area of residence, and education level. Descriptive statistics by sex and age as well as general linear models by age group were performed. The proportions of individuals meeting the moderate-to-vigorous intensity physical activity, muscular strengthening exercises, and sleep guidelines were, respectively, 21.6%, 22.1%, and 32.5% in male youth; 6.9%, 4.5%, and 22.8% in female youth; 55.5%, 30.8%, and 54.0% in male adults; 48.8%, 14.4%, and 57.6% in female adults; 44.0%, 30.6%, and 45.5% in male older adults; and 29.5%, 8.9%, and 37.3% in female older adults. The proportions of individuals showing the most ideal combinations of 24-h movement behaviors were only 3.2% in youth, 0.4% in adults, and 0 in older adults. Universally, older age, female sex, or living in metro Seoul were associated with unfavorable patterns of 24-h movement behaviors across different age groups. However, the associations of income and education with movement behaviors were mixed across age groups. Overall, the proportion of South Koreans with a healthy 24-h movement behavior pattern is low. The sociodemographic correlates of different types of 24-h movement behaviors should be considered when designing targeted interventions for the promotion of healthy active living for South Koreans. • This study provides the most up-to-date prevalence estimates of physical activity, sedentary time, and sleep duration among a nationally representative sample of South Koreans aged 12 years and older. • The proportions of South Korean youth, adults, and older adults showing the most ideal combinations of 24-h movement behaviors are 3.2%, 0.4%, and 0, respectively. • In each age group, individuals who are older, female, or living in metro Seoul generally show unfavorable patterns of 24-h movement behaviors. • Many South Koreans do not engage in healthy 24-h movement behaviors. • When 24-h movement behaviors are considered together and separately, youth, compared with adults and older adults, show the most unfavorable behavioral patterns. [ABSTRACT FROM AUTHOR]

Sedentary behavior (SB) is known to be detrimental to the overall health of adolescents. However, it is less understood if mental health outcomes differ by different types of SB. The objective of this study was to examine the association between different types of SB and mental health outcomes among South Korean adolescents. Self-reported, nation-wide, cross-sectional data from 2018 to 2019 Korea Web-based Youth Risk Behavior Surveys (N = 122,923) were used. Different types of SB were categorized into quartiles. Mental health outcomes were dichotomized (yes/no). Multivariate logistic regressions were performed after adjusting for relevant covariates. Of 97,171 (age:12–18yrs; girls:49.4%) eligible adolescents, the overall prevalence of sadness/hopelessness, suicidal thoughts, and suicide plan/attempt were 26.8%, 12.6%, and 4·9%, respectively. Overall, prolonged total and non-academic SB (4th quartile) were associated with sadness/hopelessness and suicidal thoughts for both genders and suicidal plan/attempt for girls only. Academic SB was not associated with any of the mental health outcomes. Prolonged Internet use (4th quartile) was also associated with sadness/hopelessness (OR:1.26, 95%CI:1.19–1.34), suicidal thoughts (OR:1.42, 95%CI:1.32–1.53), and suicidal plan/attempt (OR:1.26, 95%CI:1.13–1.40) among girls, but only with suicidal thoughts (OR:1.24, 95%CI:1.13–1.36) among boys. In contrast, the 2nd and 3rd quartiles of Internet use were inversely associated with sadness/hopelessness (OR:0.91, 95%CI:0.85–0.97, 3rd quartile) and suicidal plan/attempt (OR:0.69, 95%CI:0.59–0.80, 3rd quartile) among boys. Prolonged total and non-academic SB are detrimental to mental health outcomes among Korean adolescents. More consistent negative associations were found between Internet use and mental health outcomes among girls. • Prolonged non-academic sedentary time was correlated with adverse mental health. • Prolonged academic sedentary time was not correlated with adverse mental health. • Associations between non-academic Internet use and mental health differed by gender. • Gender-specific distinctions regarding sedentary time guidelines are warranted. [ABSTRACT FROM AUTHOR]

Objective Pancreatic β-cell mass and function are critical in glucose homeostasis. Their regulatory mechanisms have been studied principally under experimental conditions of reduced β-cell numbers, such as β-cell ablation and partial pancreatectomy. In the present study, we generated an opposite mouse model with an excessive amount of ectopic β-cells, and analyzed its consequence on β-cell mass and survival. Methods Mice underwent sub-renal transplantation (SRT) of pseudo-islets generated from a pancreatic β-cell line MIN6 or intra-pancreatic transplantation (IPT) of MIN6 cells, and morphological and functional changes of their endocrine pancreata were analyzed. Cellular fate of pancreatic β-cells after transplantation was traced using RipCre:Rosa26-tdTomato mice. By using MIN6 cells, we evaluated the roles of extracellular glucose, membrane potential, and insulin signaling on β-cell survival. Results SRT mice developed severe, progressive hypoglycemia associated with marked reduction in insulin-positive (Ins + ) cell mass and apparent increase in apoptotic Ins + cells. In in vitro experiments of MIN6 cells, insulin signaling blockade potently induced cell death, suggesting that local insulin action is required for β-cell survival. In fact, IPT ( i.e. transplantation close to endogenous β-cells) resulted in fewer apoptotic Ins + cells compared with those induced by SRT. On the other hand, β-cell mass was decreased in proportion to the decrease in blood glucose levels in both SRT and IPT mice, suggesting a contribution of hypoglycemia induced by systemic hyperinsulinemia. Conclusion Insulin plays distinct roles in β-cell survival and β-cell mass regulation through its local and systemic actions on β-cells, respectively. [ABSTRACT FROM AUTHOR]

Zygoma reduction malarplasty is a standard procedure primarily performed in Asia on patients who prefer an oval facial shape. The technique is well established and standardized. However, the esthetic results are frequently unsatisfactory or accompanied by complications such as nonunion, malunion, and cheek drooping. These complications are generally attributed to postoperative bone fragment movement. In this study, we present an improvement to this standard procedure that involves modifying the surgical technique. With our suggested modification, the chance of displacement is decreased because of increased locking resulting from greater surface-to-surface contact between the posterior bone segments. Moreover, the prominence of the anterior zygoma is maintained, whereas posterior zygoma width is slightly decreased. In our technique, fixation is performed only in the zygoma body area, and posterior fixation can be avoided. In addition, in cases where fixation is not performed, the protrusion of the posterior aspect of the articular tubercle can be decreased by grinding. We believe that the modified technique has the potential to markedly improve the treatment outcomes of zygoma reduction malarplasty. [ABSTRACT FROM AUTHOR]