46 results on '"Lecointre, Lise"'
Search Results
2. Ultrasound-guided robotic surgical procedures: a systematic review
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Pavone, Matteo, Seeliger, Barbara, Teodorico, Elena, Goglia, Marta, Taliento, Cristina, Bizzarri, Nicolò, Lecointre, Lise, Akladios, Cherif, Forgione, Antonello, Scambia, Giovanni, Marescaux, Jacques, Testa, Antonia C., and Querleu, Denis
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Introduction: Ultrasound has been nicknamed “the surgeon’s stethoscope”. The advantages of laparoscopic ultrasound beyond a substitute for the sense of touch are considerable, especially for robotic surgery. Being able to see through parenchyma and into vascular structures enables to avoid unnecessary dissection by providing a thorough assessment at every stage without the need for contrast media or ionising radiation. The limitations of restricted angulation and access within the abdominal cavity during laparoscopy can be overcome by robotic handling of miniaturised ultrasound probes and the use of various and specific frequencies will meet tissue- and organ-specific characteristics. The aim of this systematic review was to assess the reported applications of intraoperative ultrasound-guided robotic surgery and to outline future perspectives. Methods: The study adhered to the PRISMA guidelines. PubMed, Google Scholar, ScienceDirect and ClinicalTrials.gov were searched up to October 2023. Manuscripts reporting data on ultrasound-guided robotic procedures were included in the qualitative analysis. Results: 20 studies met the inclusion criteria. The majority (53%) were related to the field of general surgery during liver, pancreas, spleen, gallbladder/bile duct, vascular and rectal surgery. This was followed by other fields of oncological surgery (42%) including urology, lung surgery, and retroperitoneal lymphadenectomy for metastases. Among the studies, ten (53%) focused on locating tumoral lesions and defining resection margins, four (15%) were designed to test the feasibility of robotic ultrasound-guided surgery, while two (10.5%) aimed to compare robotic and laparoscopic ultrasound probes. Additionally two studies (10.5%) evaluated the robotic drop-in probe one (5%) assessed the hepatic tissue consistency and another one (5%) aimed to visualize the blood flow in the splenic artery. Conclusion: The advantages of robotic instrumentation, including ergonomics, dexterity, and precision of movements, are of relevance for robotic intraoperative ultrasound (RIOUS). The present systematic review demonstrates the virtue of RIOUS to support surgeons and potentially reduce minimally invasive procedure times.
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- 2024
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3. Full-field optical coherence tomography imaging for intraoperative microscopic extemporaneous lymph node assessment.
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Pavone, Matteo, Spiridon, Irene A., Lecointre, Lise, Seeliger, Barbara, Scambia, Giovanni, Venkatasamy, Aïna, and Querleu, Denis
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- 2023
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4. Comparison of retroperitoneal and transperitoneal surgical routes in laparoscopic nodal staging for locally advanced cervical cancers (FIGO IB3-IVA).
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Pécout, Marie, Phalippou, Jérôme, Azaïs, Henri, Ouldamer, Lobna, Bolze, Pierre Adrien, Ballester, Marcos, Huchon, Cyrille, Mimoun, Camille, Akladios, Cherif, Lecointre, Lise, Raimond, Emilie, Graesslin, Olivier, Carcopino, Xavier, Lavoué, Vincent, Bendifallah, Sofiane, Touboul, Cyril, Dabi, Yohan, Canlorbe, Geoffroy, Koskas, Martin, and Chauvet, Pauline
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LYMPHADENECTOMY ,CERVICAL cancer ,LENGTH of stay in hospitals ,REOPERATION ,LAPAROSCOPIC surgery ,SURGICAL complications - Abstract
This study compares morbidity and mortality associated with retroperitoneal and transperitoneal para-aortic lymphadenectomy (PAAL) for pretherapeutic nodal staging of locally advanced cervical cancers (FIGO IB3–IVA). Pre-, per- and postoperative data of patients treated for locally advanced stage cervical cancer between 1999 and 2018 in 12 French referral centers (FRANCOGYN Study Group) were retrospectively collected. The study was conducted using a sample of 448 patients, of whom 223 (49,8%) underwent retroperitoneal (group 1) and 225 (50,2%) had transperitoneal PAAL (group 2). No differences were noted concerning clinical and histological characteristics between the two groups. Among these 448 patients, 23 (5,1%) had an intraoperative complication (9 (2,0%) in group 1 and 14 (3,1%) in group 2, p = 0.28) and 47 (10,5%) had a postoperative complication (22 (4,9%) in group 1 and 25 (5,6%) in group 2, p = 0.44), only one of which required revision surgery but the patient died. The length of hospital stay was significantly shorter in group 1 than in group 2 (3.97 versus 4.88 days, p < 0.001). There was no significant difference in mortality between the two groups; 34 of 223 patients in group 1 (15.3%) and 40 of 225 patients in group 2 (15.6%) died (HR = 0.968, 95% CI [0.591–1.585]). There was no significant difference in recurrence-free or overall survival between the two groups. Retroperitoneal PAAL appears as a valuable and safety surgical route for nodal staging in locally advanced cervical cancer compared with standard transperitoneal PAAL. [ABSTRACT FROM AUTHOR]
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- 2022
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5. Exploring uterine involvement in hysterectomy samples following conization for adenocarcinoma in situ of the uterine cervix: Insights from a multicenter study by the FRANCOGYN group
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Le Gac, Marjolaine, Benoit, Louise, Koual, Meriem, Bentivegna, Enrica, Bolze, Pierre-Adrien, Kerbage, Yohan, Raimond, Emilie, Lecointre, Lise, Carcopino, Xavier, Canlorbe, Geoffroy, Philip, Charles-André, Nguyen-Xuan, Huyen-Thu, Bats, Anne-Sophie, and Azaïs, Henri
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Adenocarcinoma in situ (AIS) of the cervix can progress to invasive adenocarcinoma. While hysterectomy is standard, conservative management may be considered for women desiring future pregnancies. This study aimed to determine the prevalence of residual disease in hysterectomy specimens following excisional therapy with clear margins for AIS.
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- 2024
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6. Multicentric evaluation of a 3D-printed simulator for COVID- 19 nasopharyngeal swab collection in testing centers.
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Lecointre, Lise, Venkatasamy, Aïna, Wehr, Mégane, Koch, Antoine, Sananes, Axel, Debry, Christian, Lodi, Massimo, and Sananes, Nicolas
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- 2021
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7. Artificial intelligence-based radiomics models in endometrial cancer: A systematic review.
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Lecointre, Lise, Dana, Jérémy, Lodi, Massimo, Akladios, Chérif, and Gallix, Benoît
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RADIOMICS ,ARTIFICIAL intelligence ,ENDOMETRIAL cancer ,MAGNETIC resonance imaging ,DEEP learning - Abstract
Radiological preoperative assessment of endometrial cancer (EC) is in some cases not precise enough and its performances improvement could lead to a clinical benefit. Radiomics is a recent field of application of artificial intelligence (AI) in radiology. To investigate the contribution of radiomics on the radiological preoperative assessment of patients with EC; and to establish a simple and reproducible AI Quality Score applicable to Machine Learning and Deep Learning studies. We conducted a systematic review of current literature including original articles that studied EC through imaging-based AI techniques. Then, we developed a novel Simplified and Reproducible AI Quality score (SRQS) based on 10 items which ranged to 0 to 20 points in total which focused on clinical relevance, data collection, model design and statistical analysis. SRQS cut-off was defined at 10/20. We included 17 articles which studied different radiological parameters such as deep myometrial invasion, lympho-vascular space invasion, lymph nodes involvement, etc. One article was prospective, and the others were retrospective. The predominant technique was magnetic resonance imaging. Two studies developed Deep Learning models, while the others machine learning ones. We evaluated each article with SRQS by 2 independent readers. Finally, we kept only 7 high-quality articles with clinical impact. SRQS was highly reproducible (Kappa = 0.95 IC 95% [0.907–0.988]). There is currently insufficient evidence on the benefit of radiomics in EC. Nevertheless, this field is promising for future clinical practice. Quality should be a priority when developing these new technologies. • Current preoperative staging may be inaccurate and underestimate disease extension. • Radiomics may improve preoperative radiological assessment of endometrial carcinoma. • Radiomics models should follow high-quality standards to ensure generalizability. • Evidence of benefit of these model remains insufficient to be part of clinical practice. [ABSTRACT FROM AUTHOR]
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- 2021
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8. Robotically assisted augmented reality system for identification of targeted lymph nodes in laparoscopic gynecological surgery: a first step toward the identification of sentinel node
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Lecointre, Lise, Verde, Juan, Goffin, Laurent, Venkatasamy, Aïna, Seeliger, Barbara, Lodi, Massimo, Swanström, Lee L., Akladios, Chérif, and Gallix, Benoît
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Background: To prove feasibility of multimodal and temporal fusion of laparoscopic images with preoperative computed tomography scans for a real-time in vivo-targeted lymph node (TLN) detection during minimally invasive pelvic lymphadenectomy and to validate and enable such guidance for safe and accurate sentinel lymph node dissection, including anatomical landmarks in an experimental model. Methods: A measurement campaign determined the most accurate tracking system (UR5-Cobot versus NDI Polaris). The subsequent interventions on two pigs consisted of an identification of artificial TLN and anatomical landmarks without and with augmented reality (AR) assistance. The AR overlay on target structures was quantitatively evaluated. The clinical relevance of our system was assessed via a questionnaire completed by experienced and trainee surgeons. Results: An AR-based robotic assistance system that performed real-time multimodal and temporal fusion of laparoscopic images with preoperative medical images was developed and tested. It enabled the detection of TLN and their surrounding anatomical structures during pelvic lymphadenectomy. Accuracy of the CT overlay was > 90%, with overflow rates < 6%. When comparing AR to direct vision, we found that scores were significatively higher in AR for all target structures. AR aided both experienced surgeons and trainees, whether it was for TLN, ureter, or vessel identification. Conclusion: This computer-assisted system was reliable, safe, and accurate, and the present achievements represent a first step toward a clinical study. Graphical abstract:
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- 2022
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9. Randomized Study Comparing a Reusable Morcellator with a Resectoscope in the Hysteroscopic Treatment of Uterine Polyps: The RESMO Study.
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Stoll, François, Lecointre, Lise, Meyer, Nicolas, Faller, Emilie, Host, Aline, Hummel, Michel, Boisrame, Thomas, Akladios, Cherif, and Garbin, Olivier
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Study Objective: To compare a reusable hysteroscopic morcellator and standard resectoscopes in the hysteroscopic management of uterine polyps.Design: Single-center randomized prospective single-blind trial (resectoscope-morcellator study).Setting: Centre Médico-chirurgical Obstétrique teaching hospital, Strasbourg University Hospitals, France.Patients: All patients presenting with a single endometrial polyp of size 1 cm or larger.Interventions: After consent, the patients were randomized into 2 groups: hysteroscopic morcellation (HM) group or standard resection (SR) group. Office-based review hysteroscopy was performed 6 weeks to 8 weeks after surgery. Primary end point: time of morcellation or resection.Secondary Outcomes: total operating time (minutes), volume of fluid used (mL), fluid deficit (mL), number of morcellator or resectoscope insertions, operator comfort (visual analog scale: 0 to 10) and quality of vision (0 to 5), perioperative complications, completeness of resection, need to convert to another technique, pain assessment (visual analog scale), and length of hospitalization. At review hysteroscopy, we noted whether the resection or morcellation had been effective and if synechiae were present or absent. Statistical analyses followed Bayesian methods.Measurements and Main Results: Ninety patients were randomized: 45 in the HM group and 45 in the SR group. The average size of polyps at hysteroscopy was 13.3 mm. Morcellation time was lower than resection time (6.1 minutes vs 9 minutes; p [HM < SR] = .996). This also applied to total operating time (12.7 minutes vs 15.6 minutes; p [HM < SR] = .985), number of device insertions (1.50 vs 6; p [HM < SR] > .999), volume of fluid used (766.9 mL vs 1118.9 mL; p [HM < SR] = .994), and fluid deficit (60.2 mL vs 169.8 mL; p [HM < SR] = .989). Operator comfort was better in the HM group (8.4 vs 7.4; p [HM > SR] = .999) as was visualization (4 vs 3.7; p [HM > SR] = .911, highly probable). Operative complications were higher in the SR group (5 vs 0; p [HM < SR] = .989]. One patient in the SR group died after surgery owing to an anesthetic complication (anaphylactic shock complicated by pulmonary embolism). No differences were noted between the groups for pain assessment, length of hospitalization, and outcome on review hysteroscopy.Conclusion: The reusable morcellator is quicker, uses less fluid with less deficit and fewer introductory maneuvers, and offers better comfort and visualization than the resectoscope while being as effective for the hysteroscopic treatment of uterine polyps. [ABSTRACT FROM AUTHOR]- Published
- 2021
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10. Augmented reality in gynecologic laparoscopic surgery: development, evaluation of accuracy and clinical relevance of a device useful to identify ureters during surgery
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Akladios, Cherif, Gabriele, Victor, Agnus, Vincent, Martel-Billard, Camille, Saadeh, Ralph, Garbin, Olivier, Lecointre, Lise, and Marescaux, Jacques
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Objective: To develop and evaluate a non-invasive surgical assistance based on augmented reality (AR) in the detection of ureters on animal model. Method: After an experimental prototyping step on two pigs to determine the optimal conditions for visualization of the ureter in AR, three pigs were operated three times at 1 week intervals. The intervention consisted of an identification of the ureter, with and without the assistance of AR. At the end of the intervention, a clip was placed on the AR-proposed ureter to evaluate its accuracy. By doing a cone beam computed tomography, we measured the distance between the contrasted ureter and the clips in the acquired volume. Thirteen videos were recorded, allowing subsequent evaluation of the clinical relevance of the device. Results: The feasibility of the technique has been confirmed. The margin of error was 1.77 mm (± 1.56 mm) for ureter localization accuracy. In order to evaluate the perceived relevance and accuracy in the detection of AR-assisted ureter, 58 gynecological surgeons were shown the videos then questioned. Of the 754 responses obtained (13 videos × 58 surgeons), the ureter was identified in direct vision in 31.2% of cases versus 81.7% in AR (pvalue 3.62 × 10
−7 ). When looking at pigs that had already had one or two operations, the ureter was identified in only 16% of cases with direct vision compared to 76.1% with AR (p-value 5.48 × 10−19 ). In addition, 67% of surgeons felt that AR allowed them to better identify the ureters and 61% that AR reconstruction was accurate. Conclusion: This first AR device showed a satisfactory precision in the detection of ureters with a favorable opinion of surgeons. This surgical assistance system could be helpful in the performance of difficult procedures, for example in the case of patients, which have undergone multiple surgeries in the past.- Published
- 2020
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11. Ovarian carcinoma in patients aged ≥80 years: A retrospective multicenter study of management and survival in the FRANCOGYN population
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Bulot, Anne–Lise, Dion, Ludivine, Timoh, Krystel Nyangoh, Dupré, Pierre François, Azaïs, Henri, Touboul, Cyril, Dabi, Yohann, Graesslin, Olivier, Raimond, Emilie, Costaz, Hélène, Kerbage, Yohan, Huchon, Cyrille, Mimoun, Camille, Koskas, Martin, Akladios, Cherif, Lecointre, Lise, Canlorbe, Geoffroy, Chauvet, Pauline, Ouldamer, Lobna, Carcopino, Xavier, Gauthier, Tristan, Bendifallah, Sofiane, Levêque, Jean, and Lavoué, Vincent
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The aims of this study were to describe survival outcomes in patients with ovarian cancer aged ≥80 years and to explore predictors of poor prognosis.
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- 2024
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12. A step-by- step demonstration of laparoscopic sentinel lymph node mapping according to current guidelines.
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Lecointre, Lise, Lodi, Massimo, Martel, Camille, Gallix, Benoît, Querleu, Denis, and Akladios, Chérif
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- 2022
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13. Impact of cervical excisional dimensions on endocervical margins status in adenocarcinoma in situ of the uterine cervix: A multicenter study from the FRANCOGYN group
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Bartin, Raphael, Delangle, Romain, Mergui, Jean-Luc, Azaïs, Henri, Bolze, Pierre-Adrien, Philip, Charles-Andre, Kerbage, Yohan, Raimond, Emilie, Lecointre, Lise, Carcopino, Xavier, Castela, Mathieu, Uzan, Catherine, and Canlorbe, Geoffroy
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Excisional procedures have a central role in the management of adenocarcinoma in situ of the cervix (AIS). We aimed to evaluate the relationship between the excisional specimen dimensions and the endocervical margin status.
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- 2023
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14. Bilateral posterior Richter sacrospinous fixation with native tissue: Anatomical and functional results and quality of life assessment over 10 years
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Gaultier, Victor, Martel, Camille, Boisramé, Thomas, Faller, Emilie, Lecointre, Lise, and Akladios, Cherif
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Pelvic organ prolapse (POP) is a common condition that affects 50% of women who have given birth in their lifetime. With stop of vaginal mesh sale in 2019, the sacrospinous fixation technique according to Richter with native tissue has seen its incidence tripled in 15 years. Classically, sacrospinous fixation according to Richter is performed unilaterally, however its unilateral or bilateral character is controversial. Objective of this work is to evaluate the efficacy and safety of bilateral sacrospinous fixation according to Richter by the posterior approach with native tissue (SSB).
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- 2023
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15. Deep infiltrating endometriosis: Laparoscopic nerve-sparing surgery and use of neutral argon plasma
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BUTTIGNOL, Megane, FALLER, Emilie, LECOINTRE, Lise, BOISRAME, Thomas, and AKLADIOS, Cherif
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To present a minimally approach to the management of deep pelvic endometriosis by nerve-sparing surgery and use of neutral argon plasma for extensive endometriotic lesions.
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- 2023
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16. Laparoscopic En Bloc Pelvic Resection with Rectosigmoid Resection and Anastomosis for Stage IIB Ovarian Cancer: Hudson's Procedure Revisited.
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Lecointre, Lise, Gabriele, Victor, Faller, Emilie, Boisramé, Thomas, Martel, Camille, Host, Aline, Garbin, Olivier, and Akladios, Chérif
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Study Objective: To demonstrate a systematic approach to the laparoscopic en bloc pelvic resection with rectosigmoid resection and anastomosis as part of ovarian cancer treatment in a tertiary gynecologic surgery referral center.Design: This video illustrates an en bloc pelvic resection performed par laparoscopy in 10 steps.Setting: A 56-year-old patient with an advanced high-grade serous ovarian cancer extending into the rectum was amenable to primary debulking surgery in accordance with the French guidelines [1]. In diagnostic laparoscopy, a bilateral adnexectomy was performed, and the pelvic carcinomatosis was considered primarily resectable. Histopathology of the subsequent en bloc resection was consistent with stage IIB high-grade serous ovarian cancer with an indication for adjuvant chemotherapy.Intervention: The Hudson's procedure revisited consists of a radical monobloc excision by way of a completely extraperitoneal dissection and total mobilization of the rectum. In this case, owing to rectal invasion, we achieved a laparoscopic radical resection including rectosigmoidectomy and primary anastomosis without the need for a defunctioning stoma [2].Conclusion: Traditionally, an en bloc pelvic resection with rectosigmoid resection and anastomosis was performed by laparotomy. The feasibility of performing laparoscopic optimal cytoreductive surgery in selected patients with advanced ovarian cancer was recently demonstrated without compromising survival in case of low residual disease. The prognosis depends rather on the resectability than on the operative access. However, the radicality and completeness of the cytoreduction, as well as the potential risk of tumor seeding, remain controversially discussed. Here, we demonstrate the minimally invasive approach following the same operative strategy as in open surgery. In this way, the radicality of the "en bloc resection" entailing avoidance of tumor rupture, less bleeding, and less urethral injury is combined with the benefits of a minimally invasive access. In expert hands, this procedure can be performed laparoscopically for other pelvic malignancies with peritoneal carcinomatosis. [ABSTRACT FROM AUTHOR]- Published
- 2022
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17. Adolescent Endometriosis: Report of a Series of 55 Cases With a Focus on Clinical Presentation and Long-Term Issues.
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Audebert, Alain, Lecointre, Lise, Afors, Karolina, Koch, Antoine, Wattiez, Arnaud, and Akladios, Cherif
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Study Objective To report the clinical presentation and long-term issues of adolescent endometriosis. Design Retrospective cohort study. Setting Single private clinical center, Bordeaux, France. Patients Adolescents with a confirmed diagnosis of endometriosis. Interventions Surgical excision or ablation or lesions performed at laparoscopy. Measurements and Main Results Fifty-five adolescents, ages from 12 to 19 years (mean age 17.8), who were diagnosed with endometriosis from March 1998 to April 2013 were included in the study. Pain of various types was the leading symptom in all patients, except 2. Twenty-three patients had an adnexal mass identified preoperatively, and 5 had an associated infertility issue at the time of diagnostic laparoscopy. Four patients had an associated genital malformation. Fifty-one percent of the patients had a history of appendectomy. A familial history of endometriosis was reported by 19 patients (34.5%), with a first-degree relative affected in 14 cases (25.45%), and 47.3% of patients were smoking at least 5 cigarettes a day. Superficial implants was encountered in 31 cases (56.4%), endometriomas in 18 cases (32.72%), and deep infiltrating endometriosis (DIE) in 6 cases (10.90%). Sixty percent of patients were scored as stages I to II and 40% as stages III to IV. Five patients were lost to follow-up, and 37 had a follow-up ranging from 36 to 315 months (mean follow-up 125.5 months). Among the 50 patients not lost to follow-up, 13 (26%) had either no pain, or improved and had acceptable pain with medical treatment. Seventeen patients of the 50 adolescents not lost to follow-up (34%) underwent a repeat laparoscopy. A subsequent laparoscopic and/or magnetic resonance imaging scan was performed in 35 patients because of persistent pain. Among these, there was 12 endometriomas (7 recurrences) and 12 DIEs (3 recurrences), giving recurrence rates for endometriomas and DIEs of 36.84% and 50%, respectively. During the study, 18 patients wished to have a child. Thirteen had a delivery (72.2%), and 9 pregnancies occurred in patients who initially presented with stage I to II endometriosis. Of the 11 patients who had subfertility, 6 successfully conceived (54.5%). Conclusions Adolescent endometriosis is not a rare condition. In our study a familial history was reported in more than one-third of patients. Among those patients treated for DIE, there was a trend for higher rates of recurrences (symptoms or lesions) that required repeat laparoscopy. However, the impact on subsequent fertility appeared to have been limited. [ABSTRACT FROM AUTHOR]
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- 2015
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18. Intérêts de la centralisation de la chirurgie du cancer de l’ovaire en France
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Meurette, Jacques, Daraï, Emille, Tajahmady, Ayden, Fouard, Annie, Ducastel, Anne, Collin-Bund, Virginie, Jochum, Floriane, Lecointre, Lise, Querleu, Denis, and Akladios, Chérif
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Faire un état des lieux de la chirurgie du cancer de l’ovaire, en France, de 2009 à 2016 et étudier l’impact du volume d’activité sur la morbidité et mortalité par établissement.
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- 2023
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19. Preliminary observational study of the implementation of hyperthermic intraperitoneal chemotherapy in ovarian cancer in the gynecological surgery department at the University Hospital of Strasbourg
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Collin-Bund, Virginie, Lecointre, Lise, Ross, Célia, Faller, Emilie, Boisramé, Thomas, Minella, Chris, Baldauf, Jean-Jacques, and Akladios, Chérif
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According to French guidelines, hyperthermic intraperitoneal chemotherapy (HIPEC) can be performed for Federation of Gynecology and Obstetrics stage III primary epithelial ovarian, tubal, and peritoneal cancers that are initially unresectable after 3 or 4 cycles of intravenous chemotherapy. The main objective of this preliminary study was to analyze the components necessary for the establishment of HIPEC in an expert gynecological oncological surgery center. The secondary objective was to compare HIPEC using conventional laparotomy and laparoscopic approaches.
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- 2023
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20. Feasibility and clinical value of virtual reality for deep infiltrating pelvic endometriosis: A case report
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Martel, Camille, Arnalsteen, Charlotte, Lecointre, Lise, Lapointe, Mathilde, Roy, Catherine, Faller, Emilie, Boisramé, Thomas, Soler, Luc, and Akladios, Cherif
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Deep infiltrating pelvic endometriosis and its surgical management is associated with a risk of major postoperative complications. Magnetic Resonance Imaging (MRI) is recommended preoperatively in order to obtain the most precise mapping of the extent of endometriotic lesions. The aim of this work was to assess the feasibility and clinical interest of 3D modeling by surface rendering as a preoperative planning tool in a patient with deep infiltrating pelvic endometriosis. We report on a 42 years old patient with history of endometriosis and persistent pain underwent pre operative imaging with MRI that was consistent with deep infiltrating endometriosis. A 3D model of the deep infiltrating endometriosis was generated from the MRI and retrospectively compared to the intra-operative findings. The nodule's location and relationship to the uterus and the rectum was clearly defined by the 3D model and correlated with surgical findings. Virtual reality based on 3D models could be an interesting tool to assist in the preoperative planning of complex surgeries.
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- 2023
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21. Impact of severe obesity in the management of patients with high-risk endometrial cancer: A FRANCOGYN study
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Simon, Ombline, Dion, Ludivine, Nyangoh Timoh, Krystel, Dupré, Pierre François, Azaïs, Henri, Bendifallah, Sofiane, Touboul, Cyril, Dabi, Yohan, Graesslin, Olivier, Raimond, Emilie, Costaz, Hélène, Kerbage, Yohan, Huchon, Cyrille, Mimoun, Camille, Koskas, Martin, Akladios, Cherif, Lecointre, Lise, Canlorbe, Geoffroy, Chauvet, Pauline, Ouldamer, Lobna, Levêque, Jean, and Lavoué, Vincent
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To assess the surgical management and survival of severely obese patients with high-risk endometrial cancer.
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- 2022
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22. Trachelectomy: How is it actually done? A review from FRANCOGYN group Titre: Trachélectomie: comment faire en pratique ? Revue de la littérature par le groupe FRANCOGYN
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Lefebvre, Alice, Raimond, Emilie, Chauvet, Pauline, Touboul, Cyril, Canlorbe, Geoffroy, Lavoué, Vincent, Ouldamer, Lobna, Collinet, Pierre, Bendifallah, Sofiane, Carcopino, Xavier, Lecointre, Lise, and Kerbage, Yohan
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Because of the peak incidence of cervical cancer between the ages of 35 and 44 and the increasing age of first pregnancy, the issue of fertility preservation in cases of early-stage cervical cancer in women in this reproductive age category arises. Early-stage cervical cancer patients have a good prognosis and are surgically treated in cases of mildly aggressive human papillomavirus-related histological type (squamous cell carcinoma, adenocarcinoma), FIGO stage IA to IB1 (i.e., <2 cm), with shallow stromal invasion (<10 mm) and without the presence of lymph-vascular space invasion or lymph node or regional involvement. Under these conditions, conservative treatment by trachelectomy, which has recurrence-free and overall survival rates equivalent to that of hysterectomy, may be considered. After a complete pre-therapeutic assessment, including pelvic lymphadenectomy, to eliminate all contraindications to conservative treatment, a simple or enlarged trachelectomy can be chosen. According to some authors, the route of entry (vaginal, simple or robot-assisted laparoscopy, laparotomy) has no significant effect on survival or fertility, although the literature on the subject is limited. Trachelectomy offers good results in terms of fertility, with an estimated pregnancy rate of between 23% and 55% and a live birth rate of 70%. The significant reduction of the cervix associated with the procedure increases the risk of prematurity. However, this can be prevented by the use of a permanent cerclage. Close follow-up of these patients is essential for a minimum period of 5 years in order to detect any recurrence or postoperative complications.
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- 2022
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23. Nerve Anatomy Around Lumbo-aortic Lymphadenectomy by Retroperitoneal Approach.
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Osada, Marine, Lecointre, Lise, Lodi, Massimo, Faller, Emilie, Boisrame, Thomas, Host, Aline, Gabriele, Victor, Garbin, Olivier, and Akladios, Cherif
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Study Objective: To describe the anatomy of the nerves during a laparoscopic retroperitoneal para-aortic lymphadenectomy with prioritization of their preservation.Design: Demonstration of a nerve-preserving para-aortic lymphadenectomy.Setting: A 65-year-old woman with no significant medical history underwent diagnostic laparoscopy for evaluation of a right ovarian mass. In the absence of peritoneal carcinomatosis, bilateral adnexectomy wasperformed with pathology revealing a high-grade tubo-ovarian serous carcinoma. In accordance with French Guidelines for management of ovarian cancer, operative staging including pelvic and para-aortic lymphadenectomy was recommended [1]. Final pathology following staging surgery was consistent with stage IA high-grade serous ovarian cancer prompting administration of adjuvant chemotherapy postoperatively.Interventions: We performed a lumbo-aortic lymphadenectomy with preservation of the following nerves: the superior hypogastric plexus, the lumbar splanchnic nerves and the sympathetic trunk.Conclusion: Although there are conflicting data as to the benefit of staging lymphadenectomy in women with presumed early stage high-grade serous ovarian cancer, current French Guidelines recommend its performance. When doing so, effort should be made to avoid injury to adjacent normal structures, and in doing so, minimize potential morbidity. The neural structures preserved in this case are part of the sympathetic contingent and participate in the innervation of the abdomen and pelvic viscera. The sympathetic contingent is responsible for the vasomotricity but is also involved in the contraction of the internal genitalia during orgasm and in the inhibition of the peristaltic contractions of the rectum. As such, its preservation may avoid certain postoperative complaints. When possible to do so without compromising essential elements of a cancer surgery, preservation of nerves should be considered. [ABSTRACT FROM AUTHOR]- Published
- 2022
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24. Bladder and Urinary Deep Pelvic Endometriosis: A Step-by-Step Standard Approach.
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Paté, Marie, Hauss, Anne-Sophie, Faller, Emilie, Colin, Jules, Lecointre, Lise, and Akladios, Cherif
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Study Objective: To demonstrate how to treat bladder and ureteral deep pelvic endometriosis using a laparoscopic approach with partial cystectomy and resection and end-to-end anastomosis of the ureter.Design: Step-by-step explanation of the surgery using a video approved by the local institutional review board.Setting: University Hospital of Strasbourg, France.Patients: A 27-year-old nulliparous woman with severe endometriosis stage IV (revised American Fertility Society classification score >40) of the bladder and left ureter. On pelvic magnetic resonance imaging, we found dilatation of the left ureter and left hydronephrosis induced by a 17-mm endometriosis nodule. A JJ probe was placed on the left ureter before the surgery because of dilatation of the ureter and decreased renal function.Interventions: During the exploration, we found an abdominal cavity free of adhesion. There was an endometriosis implant in the bladder in front of the uterus and a large nodule of the left uterosacral ligament that was compressing the ureter. In the first step, we made a section of the round ligament to perform anterior ureterolysis and progressive dissection of the nodule surrounding the ureter. Once the nodule was resected, tight stenosis was observed approximately 1 cm from the bladder. The vesicouterine and vesicovaginal spaces were then dissected to pass under the nodule to the vagina. We opened the dome of the bladder using the thunderbeat (Olympus) and dissected the bladder to remove the transfixing nodule while staying away from the ureters. The closure of the bladder was performed by 2 lateral sutures and a running suture using a braided suture (V-Loc) 2-0, with good tightness as checked by a blue test. Ureteral resection was performed around the JJ probe in place to remove the stenotic zone; thereafter, we performed an end-to-end anastomosis of the ureter using 4 sutures of monofilament (Monocryl) 4-0 with a good anatomic result. Finally, an omentoplasty was fixed around the ureter using a 2-0 monofilament suture (Monocryl).Measurements and Main Results: The postoperative course was uneventful. A Foley catheter was left in place for 10 days, and the JJ probe was removed 6 weeks later. The operative time was 140 minutes. The step-by-step explanation technique was simple with minimal operative difficulty and a low rate of morbidity.Conclusion: This video shows how deep urinary endometriosis can be treated laparoscopically. Mastering suturing is essential to avoid complications. [ABSTRACT FROM AUTHOR]- Published
- 2020
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25. Surgical Video Tutorial: Treatment of Congenital Vaginal Agenesis: Laparoscopic Modified Davydov in 8 Steps.
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Vermel, Muriel, Wehr, Mégane, Schwaab, Thomas, Lecointre, Lise, Host, Aline, Faller, Emilie, Akladios, Chérif, and Garbin, Olivier
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Objective: To describe the different steps of the Davydov surgical technique for creating a neovagina, emphasizing visualization of the rectovesical cleavage and peritoneal-vaginal anastomosis by laparoscopic and vaginal approaches.Design: Production of a step-by-step surgical video tutorial with narrative video footage.Setting: Uterovaginal agenesis is a rare congenital defect, observed in 1 case per 4000 to 5000 newborn female infants [1]. Vaginal agenesis treatment can be performed by different nonsurgical and surgical techniques that are based on neocavity creation. The Davydov intervention uses the pelvic peritoneum as "covering" tissue for a neocavity and avoids the use of allogenic or autologous transplants, traction devices, or specialized surgical equipment. It is a minimally invasive technique that provides long-term functionality and anatomically satisfying results [2].Interventions: We treated an 18-year-old patient with Mayer-Rokitansky-Küster-Hauser syndrome who underwent the Davydov procedure after dissatisfaction with the Franck self-expansion method. We created a neovagina using peritoneal flaps that were obtained after rectovesical cleavage by laparoscopic approach and were then fastened to the introitus by vaginal approach. Finally, the vaginal vault was reconstructed laparoscopically, and an intravaginal dilator was left in place. The result after 1 year showed the transition from a narrow vaginal dimple 2 cm in length to a neovagina 10 cm in length, permeable, well epithelialized, and correctly healed without associated stenosis. Sexual intercourse is satisfying for both partners.Conclusion: The Davydov technique is less invasive than other surgical techniques and allows good outcomes [3,4] without the invasive use of sigmoidal grafts, cutaneous flaps, or prostheses. It should be proposed to patients experiencing failure with the Franck nonsurgical method. [ABSTRACT FROM AUTHOR]- Published
- 2021
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26. Basics of immunotherapy for epithelial ovarian cancer
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Bund, Virginie, Azaïs, Henri, Bibi-Triki, Sabrina, Lecointre, Lise, Betrian, Sarah Bétrian, Angeles, Martina Aida, Eberst, Lauriane, Faller, Emilie, Boisramé, Thomas, Bendifallah, Sofiane, Akladios, Chérif, and Deluche, Élise
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Epithelial ovarian cancer (EOC) is the most lethal of all gynecological cancers.
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- 2022
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27. Sacrospinofixation of Richter in 8 Points: Original Contribution of the Laparoscopic Column in the Visualization of the Sacrospinous Ligaments.
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Zilliox, Marie, Lecointre, Lise, Boisramé, Thomas, and Akladios, Cherif
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Study Objective: Although the standard technique is currently based on laparoscopic promontofixation, the standard vaginal technique for the treatment of uterine prolapse is sacrospinofixation according to Richter [1-3]. Described by Kurt Richter in 1968, this intervention corrects the middle floor and consists of fixing the vaginal dome (after hysterectomy or not) on the sacrospinous ligament(s) [4,5]. The technique includes a wide dissection of the pararectal fossa using several Breisky valves to grip the sacrospinous ligament under strict visual control. This crucial step of the intervention implies optimal visual control for the operator but does not allow visual access to the operative assistants, which is regrettable for the purpose of teaching [2,4-6]. The aim of this surgical video is to describe the different stages of the sacrospinofixation surgical technique, showing sacrospinous ligaments during the crucial step thanks to a laparoscopic camera.Design: A step-by-step explanation of the surgery using a video (an instructive video [Video 1]) approved by the local ethics committee.Setting: Gynecological Surgery Unit, University Hospital of Strasbourg, Strasbourg, France.Patients: A 70-year-old woman with multicompartment pelvic organ prolapse.Interventions: Installation in the conventional gynecologic position with 2 operating assistants on both sides of the operator. The steps are as follows: step 1, posterior colpotomy; step 2, rectovaginal dissection and opening of the pararectal fossa; step 3, dissection of the sacrospinous ligament; and step 4, gripping of the sacrospinous ligament. The following 4 steps are realized bilaterally: step 5, suspension of the vaginal dome; step 6, beginning of vaginal closure; step 7, tightening the spinofixation threads; and step 8, ending the closure of the vaginal colpotomy.Measurements and Main Results: The operative time was 60 minutes. The operation was simple and shows precisely the sacrospinous ligaments. There were no intraoperative complications. The vaginal mesh urinary catheter was removed on day 1, and the patient was discharged on day 3.Conclusion: Thanks to a laparoscopic column, this video of the surgical technique of sacrospinofixation using the Richter procedure is an original approach to show sacrospinous ligaments. The latter is a crucial step of this surgery, which remains the reference vaginal technique for the treatment of a uterine prolapse. [ABSTRACT FROM AUTHOR]- Published
- 2019
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28. Pudendal Neurolysis by Laparoscopy.
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Pélissié, Mathilde, Fischbach, Elodie, Lecointre, Lise, Faller, Emilie, and Akladios, Chérif
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Study Objective: To show how pudendal neurolysis can be managed safely with a laparoscopic approach.Design: Stepwise demonstration of the technique with narrated video footage.Setting: The pudendal nerve is formed from spinal roots at levels S2, S3, and S4. It passes through the pelvis parallel to the pudendal vein and artery. This nerve exits the pelvis between the sacrospinous and sacrotuberous ligaments then passes through Alcock's canal. It can be compressed and responsible for pain in the gluteal and perineal regions. After confirmation of the diagnosis by positive analgesic block with computed tomography infiltration of the pudendal nerve, surgical decompression may be considered. The usual access procedures are the transglutal and transischiorectal ways.Interventions: This video shows a total laparoscopic approach for a right pudendal neurolysis. It is a step-by-step didactic video. This technique of decompression of the right pudendal nerve by laparoscopy by means of dissection of the ischiorectal fossa along the right internal obturator muscle, after visualization of the obturator vessels and identification of the pudendal nerve, allowed the section of the right sacrospinous ligament and complete removal with repositioning of the nerve in its path. The nerve was followed until it passed freely through Alcock's canal. The procedure went well and without complications, with clinical improvement on waking up.Conclusion: Pudendal nerve neurolysis by laparoscopic technique is a reproducible and safe method for treating pudendal neuralgia, allowing good visualization and dissection of the entire pelvis toward the ischiorectal fossa. [ABSTRACT FROM AUTHOR]- Published
- 2021
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29. Surgical management of deep pelvic endometriosis in France: Do we need to be a pelvic surgeon to deal with DPE?
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Pellerin, Madeleine, Faller, Emilie, Minella, Chris, Garbin, Olivier, Host, Aline, Lecointre, Lise, and Akladios, Chérif
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Endometriosis is a common disease in women, which requires a medical and surgical approach. Surgical societies recommend a multidisciplinary management in tertiary referral centers. The objective of our study is to assess the surgical management of endometriosis in France by studying the surgeons’ attitude for bowel and urinary endometriosis.
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- 2021
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30. The impact of the COVID-19 coronavirus pandemic on the surgical management of gynecological cancers: Analysis of the multicenter database of the French SCGP and the FRANCOGYN group
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Jouen, Théo, Gauthier, Tristan, Azais, Henri, Bendifallah, Sofiane, Chauvet, Pauline, Fernandez, Herve, Kerbage, Yohan, Lavoue, Vincent, Lecointre, Lise, Mimoun, Camille, Ouldamer, Lobna, Seidler, Stéphanie, Siffert, Marc, Vallin, Anne-Lyse, Spiers, Andrew, Descamps, Philippe, Lacorre, Aymeline, and Legendre, Guillaume
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The coronavirus SARS-CoV-2 (COVID-19) pandemic has put tremendous pressure on the French healthcare system. Almost all hospital departments have had to profoundly modify their activity to cope with the crisis. In this context, the surgical management of cancers has been a topic of debate as care strategies were tailored to avoid any delay in treatment that could be detrimental to patient wellbeing while being careful not to overload intensive care units.
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- 2021
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31. Frozen Pelvis Surgical Strategy in 10 Steps.
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Pellerin, Madeleine, Faller, Émilie, Calabre, Charline, Boisramé, Thomas, Lecointre, Lise, and Akladios, Cherif
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Study Objective: To describe a 10-step strategy to treat severe endometriosis with a frozen pelvis by laparoscopy.Design: Educational video.Setting: University Hospital of Strasbourg, France.Interventions: The patient was a 33-year-old nulliparous woman suffering from endometriosis. Because of pain and a desire for pregnancy, she was scheduled for surgery. After setting the patient in gynecologic position, we used a uterine manipulator to facilitate exposure. We assessed the global situation and discovered a frozen pelvis. To treat the myoma, the surgeon should use traction and countertraction as much as possible. We started with the caecum and sigmoid detachment. Then we performed a bilateral ureterolysis. Once the ureters were identified, we could perform safely the adhesiolysis of the bowel from the uterus. The adnexas could be freed and suspended with a T-Lift device to facilitate exposure. After identifying the utero sacral ligament, we opened the para rectal fossa, leading to the opening of the recto vaginal space. The anatomy was then restored, and we could define the specific surgical strategies.Conclusion: Frozen pelvis is a situation where anatomy is distorted. The surgeon should find anatomic landmarks to restore anatomy and to establish specific strategies adapted to the patient. [ABSTRACT FROM AUTHOR]- Published
- 2020
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32. Ovarian Cortex Transplantation.
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Pellerin, Madeleine, Garbin, Olivier, Teletin, Marius, Lecointre, Lise, Akladios, Cherif, and Pirrello, Olivier
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Study Objective: To describe a laparoscopic technique for the transplantation of a cryopreserved ovarian cortex.Design: Educational video.Setting: University Hospital of Strasbourg, France.Interventions: A 28-year-old nulliparous woman presented with anaplastic T lymphoma and was then treated with chemotherapy. Before the treatment, the ovarian cortex was collected by laparoscopy to preserve fertility. Remission was achieved, but the patient suffered from premature ovarian failure. At the age of 32 years, she wished to become pregnant. The patient was thus included in the research protocol Development of Ovarian Tissue Autograft in Order to Restore Ovarian Function, and the transplantation site was chosen accordingly. The cortex was stored in liquid nitrogen at -196°C after slow congelation. To restore ovarian function and because of pregnancy desire, we transplanted the cryopreserved ovarian cortex in the right ovary and inside a pocket of the peritoneum of the left ovarian fossa. The first step included adhesiolysis to treat small adhesions developed after the first surgery. On the right, the ovarian cortex was opened by an antimesial incision with cold scissors. The cryopreserved ovarian cortex was placed through the cortex of the right ovary and fixed with stitches. On the left side, the peritoneum of the ovarian fossa was opened, and a subperitoneal pocket was dissected. The cortex was inserted. It was then closed with absorbable sutures or with a hemostatic pad. Six months after her surgery, the patient had natural cycles. We monitored an ovulation of both the sides. She underwent 3 in vitro fertilizations but with failures of embryo transfer. She conceived spontaneously a year after the surgery. She gave birth to a healthy child weighing 3300 g.Conclusion: For patients who have suffered from premature ovarian failure owing to chemotherapy, ovarian cortex transplantation can restore the ovulatory function, allow in vitro fertilization, and permit, as in our case, a spontaneous pregnancy. [ABSTRACT FROM AUTHOR]- Published
- 2020
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33. Retroperitoneal Lumboaortic Lymphadenectomy Using a Vessel-Sealing Device in 10 Steps.
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Schaub, Marie, Lecointre, Lise, Faller, Emilie, Boisramé, Thomas, Wattiez, Arnaud, Baldauf, Jean-Jacques, and Akladios, Cherif
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Study Objective: Lumboaortic lymphadenectomy is frequently performed in the surgical management of different gynecologic pelvic malignancies: cervical endometrial and ovarian cancer. The retroperitoneal access presents a real advantage, allowing direct access to vascular axes, thus avoiding bowel segments. The use of a vessel-sealing device could facilitate the technique by providing an ergonomic alternative to conventional tools such as a bipolar grasper and scissors. Here the surgical technique of laparoscopic retroperitoneal lumboaortic lymphadenectomy using a vessel-sealing device in 10 steps is described.Design: Educative video (Canadian Task Force classification III).Setting: Tertiary referral center in Strasbourg, France.Patients: Women undergoing lumboaortic lymphadenectomy.Intervention: Laparoscopic retroperitoneal lumboaortic lymphadenectomy using a vessel-sealing device. The local institutional review board approved the video.Measurements and Main Results: The surgeon and assistant are positioned on the left of the patient and the column is placed in front. After peritoneal exploration 3 trocars are introduced in the left flank according to a very precise arrangement. We use a camera scope with a zero-degree view angle. After development of the extraperitoneal space and identification of the vascular landmarks, lymphadenectomy using a vessel-sealing device involves several steps in an anticlockwise direction starting from the left common iliac group. We first start with the lateroaortic group of lymph nodes. We then continue with the preaortic, interaorticocaval, and precaval supramesenteric group. After that, we perform the inframesenteric dissection of lymph nodes, the bifurcation of the aorta, and finally the right common iliac group. At the end of the procedure, in the absence of signs of metastatic lymph nodes, we open the peritoneum.Conclusion: Retroperitoneal lumboaortic lymphadenectomy using a vessel-sealing device is useful because of better ergonomics of the multitasking instrument, avoiding alternating between scissors and bipolar forceps. The surgeon will be able to use both hands for exposure and for surgery. The presence of a metastatic ganglion is an important and decisive factor in the choice of adjuvant or neoadjuvant management of cancers, especially for cervical cancer. [ABSTRACT FROM AUTHOR]- Published
- 2018
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34. Laparoscopic Management of a Rudimentary Uterine Horn.
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Faller, Emilie, Baldauf, Jean Jacques, Becmeur, François, Lehn, Anne, Akladios, Cherif Youssef, and Lecointre, Lise
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Study Objective: To demonstrate a technique of laparoscopic management of a rudimentary horn in a 12-year-old girl.Design: A step-by-step explanation of the surgery using a video (instructive video) approved by the local institutional review board.Setting: A university hospital (University Hospital of Strasbourg, Strasbourg, France).Patient: A 12-year-old girl with a uterine rudimentary horn.Intervention: We describe a case of a 12-year-old girl who had no medical history. She had her first menstruation at 11 years old with major left pelvic pain occurring each month. Ultrasonography showed a duplication of the uterus with a liquid collection on the left side; this type of malformation is called an accessory and cavitated uterine mass. Medical treatment was initiated with progestin. Magnetic resonance imaging showed a left noncommunicating rudimentary horn with a unicornuate uterus. No other malformation was present, particularly in the kidneys. A primary vaginal endoscopy was performed showing a single cervix without vaginal malformation. It was decided to perform a laparoscopic excision of the left rudimentary horn. We placed a 10-mm optical port into the umbilicus and 3 accessory 5-mm trocars. Evaluation of the abdominal cavity showed 2 normal adnexas with normal ovaries. We decided to start with a left salpingectomy using the Ligasure device (Medtronic, Minneapolis, MN), staying close to the tube to preserve ovarian vascularization. The remnant fimbria must be removed to avoid cancerization. Then, the vesicouterine septum was divided until we reached the cervix to dissect the bladder from the rudimentary horn. The broad ligament was fenestrated in order to push the left ureter laterally .The utero-ovarian pedicle was transected with the Ligasure device; the left ovary was preserved and vascularized by the left infundibulopelvic ligament. We then dissected the left uterine artery. The posterior peritoneum was opened. The resection of the rudimentary horn was performed by means of a monopolar hook. The dissection was performed slowly with selective coagulation until we reached the cavity of the horn, with old blood flowing out. The entire cavity was removed, and we confirmed the absence of communication with the other part of the uterus. Uterine reconstruction was performed with inverted separated stiches of a 2-0 braided suture, and, finally, an antiadhesion barrier was placed.Conclusions: Laparoscopic management of a uterine rudimentary horn is feasible with satisfactory uterine reconstruction. This is not the first case of this surgery performed by laparoscopy. A similar case has been published in 2015 [1], and recently another video [2] has been published describing 2 other cases. [ABSTRACT FROM AUTHOR]- Published
- 2018
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35. Laparoscopic Transperitoneal Para-Aortic Lymphadenectomy in 10 Steps.
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Martel-Billard, Camille, Goillot, Vinciane, Jacquin, Alice, Lecointre, Lise, Faller, Emilie, Boisramé, Thomas, Baldauf, Jean-Jacques, Akladios, Cherif Youssef, and Wattiez, Arnaud
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Study Objective: Laparoscopic transperitoneal lymphadenectomy has a few advantages. First, it is a minimally invasive approach, and the transperitoneal approach is also the best option when intra-abdominal surgery is indicated. Although the procedure was described more than 2 decades ago, there is a lack of diffusion of the technique. The main objective of this video is standardization and a simple description of the technique. We described this procedure in 10 logical steps, which should help to understand and perform this procedure.Methods: This video presents a systematic approach to transperitoneal lumboaortic lymphadenectomy, which is clearly divided in 10 steps ordered in a counterclockwise direction.Results: The 10 steps are as follows: step 1, retroperitoneal access; step 2, creating a space for subsequent lymphadenectomy and identification of anatomic landmarks; step 3, left common iliac lymph node dissection; step 4, right common iliac lymph node dissection; step 5, presacral lymph node dissection; step 6, lateroaortal lymph node dissection; step 7, laterocaval lymph node dissection; step 8, aortocaval lymph node dissection; step 9, vaginal extraction of bags with specimens; and step 10, vaginal suture.Conclusions: Laparoscopic transperitoneal access to lumboaortic lymph nodes is an effective method of lymphadenectomy, which may bring benefits to a patient and physician. The presented 10 steps help to perform each part of surgery in a logical sequence, making the procedure ergonomic and easier to adopt and learn. Standardization of laparoscopic techniques could help to reduce the learning curve. [ABSTRACT FROM AUTHOR]- Published
- 2018
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36. Transvaginal Resection of an Infected Sacrocolpopexy Mesh by Single-Port Trocar.
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Schaub, Marie, Lecointre, Lise, Faller, Emilie, Boisramé, Thomas, Baldauf, Jean-Jacques, and Akladios, Cherif Youssef
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Study Objective: Laparoscopy using a single port improves morbidity while keeping the same level of requirement. This technique has been evaluated in gynecology for salpingectomy, ovarian surgery, and hysterectomy. Here, the authors illustrate a new use of a single port using the transvaginal approach.Design: Case report (Canadian Task Force classification III).Setting: Tertiary referral center in Strasbourg, France.Patient: Woman age 59 years.Intervention: Single-port platform used in the transvaginal approach for resection of sacrocolpopexy mesh. The local institutional review board approved the video.Measurements and Main Results: A 59-year-old woman suffering from insulin-dependent diabetes and a tobacco user had 2 laparoscopic sacrocolpopexies for recurrent rectocele, the first in 2007 and the second in 2012. The sequences were marked by mesh erosion and granuloma in the vagina, requiring its surgical excision in 2016. The patient was then symptomatic, with an increasingly foul-smelling vaginal discharge with recurrent mesh erosion. Magnetic resonance imaging showed an abscess formation along the length of the mesh to the promontory. The patient then underwent surgery, realized under probabilistic antibiotic therapy, consisting of complete excision of the sacrocolpopexy mesh by the transvaginal approach. After putting the single-port trocar (GelPoint; Applied Medical, Rancho Santa Margarita, CA) into the vagina and obtaining distension with the insufflator (AirSeal; Conmed, Utica, NY), classic laparoscopic instruments were introduced by the single-port trocar. The mesh was entirely resected in the retroperitoneal space. Mesh was again used because the exposed space is almost always surrounded by loose granulation tissue that facilitates dissection and also prevents injury to adjacent structures such as bladder, rectum, and peritoneum. Moreover, the opening of adjacent structures will manifest gas leaks and, consequently, loss of the pneumovagina. At the end of procedure, the vagina is not closed to permit optimal drainage with a multitubular drain in the dissection space. The surgery lasted 60 minutes. The mesh excision was completed with relative ease, and there was no blood loss. Bacteriologic examination revealed the presence of Streptococcus anginosus, Klebsiella pneumoniae, and Bacteroides fragili. The operating suites were simple with great cicatrization after 6 weeks. The principal difficulties of this surgery were obtaining a good seal by the creation of cutaneous sutures. Finally, there are less conflicts between the instruments inside the single-port trocar used in transvaginally because of a more limited dissection space. Indeed, the rate of mesh erosion reached 2.4% and, in case of infection, justifies this excision.Conclusion: The transvaginal use of a single-port trocar represents a good alternative, allowing easy resection of the sacrocolpopexy mesh while remaining in the retroperitoneal space. [ABSTRACT FROM AUTHOR]- Published
- 2018
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37. Cesarean Scar Ectopic Pregnancy: Laparoscopic Resection and Total Scar Dehiscence Repair.
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Mahgoub, Sara, Gabriele, Victor, Faller, Emilie, Langer, Bruno, Wattiez, Arnaud, Lecointre, Lise, and Akladios, Cherif
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Study Objective: To illustrate a laparoscopic technique for the resection of cesarean scar ectopic pregnancy, associated with isthmocele repair.Design: Case report (Canadian Task Force classification III).Setting: A tertiary referral center in Strasbourg, France.Background: Cesarean scar pregnancy is a rare form of ectopic pregnancy. The major risk of this type of pregnancy is the early uterine rupture with massive, sometimes life-threatening, bleeding. Thus, active management of these pregnancies starting immediately after diagnosis is crucial. Therapeutic options can be medical, surgical, or a combination. Numerous case reports or case series can be found in the literature, but there are few clinical studies, which are difficult to conduct because of case rarity and inconclusiveness. A 2016 meta-analysis that included 194 articles published between 1978 and 2014 (126 case reports, 45 cases series, and 23 clinical studies) concluded that hysteroscopy or laparoscopic hysterotomy seems to be the best first-line approach to treating cesarean scar ectopic pregnancy, with uterine artery embolization reserved for significant bleeding and/or a high suspicion index for arteriovenous malformation [1]. There is no consensus on the treatment of reference, however.Patient: The case involves a 38-year-old primiparous women who underwent a cesarean section delivery in 2010 and who was diagnosed by ultrasound scan at 7 weeks gestation with cesarean scar ectopic pregnancy, which was confirmed by pelvic magnetic resonance imaging. The patient initially received medical treatment with 2 intramuscular injections of methotrexate and one local intragestational injection of KCl. Her initial human chorionic gonadotropin (hCG) level was 82 000 IU/L. Rigorous weekly biological and ultrasound monitoring revealed an involution of the ectopic pregnancy associated with decreasing hCG. No bleeding or infectious complications occurred during this period. After 10 weeks of monitoring, her hCG had stabilized at 300 IU/L, and a residual image persisted next to the cesarean scar, and thus surgical treatment was considered.Intervention: This video illustrates the laparoscopic resection of a cesarean scar ectopic pregnancy associated with isthmocele repair. The originality of this video lies in the fact that it is the first demonstration of the laparoscopic treatment of total caesarean scar dehiscence.Measurements and Main Results: The total operative time was 180 minutes. First, hysteroscopic evaluation revealed the cesarean scar dehiscence and the posterior pole of the ectopic pregnancy. Then the diagnosis of cesarean scar ectopic pregnancy was confirmed laparoscopically. The utero-ombilical truncs were clamped bilaterally. Complete enucleation of pregnancy was achieved after dissection of the vesicouterine peritoneum. Isthmocele repair was performed with closure in 2 planes. A blue dye test confirmed the tightness of the stitches. The utero-ombilical truncs were unclamped, and antiadhesion gel was applied to the new uterine scar [1]. The operation was performed successfully without complications. Intraoperative blood loss was <100 mL. The patient was discharged on postoperative day 3. No immediate complications were noticed. At 1 month after the intervention, ultrasound was normal.Conclusion: Surgical management of caesarean scar ectopic pregnancy with total dehiscence of hysterotomy can be performed safely and efficiently under laparoscopy. [ABSTRACT FROM AUTHOR]- Published
- 2018
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38. Cesarean scar pregnancy: Two case report and therapeutic management algorithm
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Legris, Marie-Laure, Gabriele, Victor, Host, Aline, Akladios, Chérif, Garbin, Olivier, and Lecointre, Lise
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We aimed to present two cases of cesarean scar pregnancy (CSP) and a literature review to discuss their management.
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- 2021
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39. Borderline ovarian tumors: French guidelines from the CNGOF. Part 1. Epidemiology, biopathology, imaging and biomarkers
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Huchon, Cyrille, Bourdel, Nicolas, Abdel Wahab, Cendos, Azaïs, Henri, Bendifallah, Sofiane, Bolze, Pierre-Adrien, Brun, Jean-Luc, Canlorbe, Geoffroy, Chauvet, Pauline, Chereau, Elisabeth, Courbiere, Blandine, De La Motte Rouge, Thibault, Devouassoux-Shisheboran, Mojgan, Eymerit-Morin, Caroline, Fauvet, Raffaele, Gauroy, Elodie, Gauthier, Tristan, Grynberg, Michael, Koskas, Martin, Larouzee, Elise, Lecointre, Lise, Levêque, Jean, Margueritte, Francois, Mathieu D’argent, Emmanuelle, Nyangoh-Timoh, Krystel, Ouldamer, Lobna, Raad, Jade, Raimond, Emilie, Ramanah, Rajeev, Rolland, Lucie, Rousset, Pascal, Rousset-Jablonski, Christine, Thomassin-Naggara, Isabelle, Uzan, Catherine, Zilliox, Marie, and Daraï, Emile
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The incidence (rate per 100 000) of borderline ovarian tumors (BOTs) increases progressively with age, starting at 15–19 years and peaking at around 4.5 cases per 100 000 at an age of 55–59 years (LE3) with a median age of 46 years. The five year survival for FIGO stages I, II, III and IV is 99.7 % (95 % CI: 96.2–100 %), 99.6 % (95 % CI: 92.6–100 %), 95.3 % (95 % CI: 91.8–97.4 %) and 77.1 % (95 % CI: 58.0–88.3 %), respectively (LE3).
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- 2021
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40. Borderline ovarian tumors: French guidelines from the CNGOF. Part 2. Surgical management, follow-up, hormone replacement therapy, fertility management and preservation
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Bourdel, Nicolas, Huchon, Cyrille, Abdel Wahab, Cendos, Azaïs, Henri, Bendifallah, Sofiane, Bolze, Pierre-Adrien, Brun, Jean-Luc, Canlorbe, Geoffroy, Chauvet, Pauline, Chereau, Elizabeth, Courbiere, Blandine, De La Motte Rouge, Thibault, Devouassoux-Shisheboran, Mojgan, Eymerit-Morin, Caroline, Fauvet, Raffaele, Gauroy, Elodie, Gauthier, Tristan, Grynberg, Michael, Koskas, Martin, Larouzee, Elise, Lecointre, Lise, Levêque, Jean, Margueritte, Francois, D’argent Mathieu, Emmanuelle, Nyangoh-Timoh, Krystel, Ouldamer, Lobna, Raad, Jade, Raimond, Emilie, Ramanah, Rajeev, Rolland, Lucie, Rousset, Pascal, Rousset-Jablonski, Christine, Thomassin-Naggara, Isabelle, Uzan, Catherine, Zilliox, Marie, and Daraï, Emile
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In the Early Stages (ES) of Borderline Ovarian Tumor (BOT), if surgery without risk of tumor rupture is possible, then laparoscopy with protected extraction is recommended over laparotomy (Grade C). In case of bilateral serous ES BOT treatment with a strategy to preserve fertility and/or endocrine function, bilateral cystectomy is recommended if possible (Grade B). In case of mucinous BOT treatment with a strategy to preserve fertility and/or endocrine function, unilateral adnexectomy is recommended (grade C). In the case of a mucinous BOT in a patient who has had an initial cystectomy, unilateral adnexectomy is recommended (grade C). In the case of treatment of a serous ES BOT in a patient who has had an initial cystectomy, with a strategy to preserve fertility and/or endocrine function, restaging surgery for adnexectomy is not recommended in the absence of suspicious residual lesions at the time of surgery and/or postoperative imaging (reference ultrasonography or pelvic MRI) (grade C). For serous or mucinous ES BOTs, routine hysterectomy is not recommended (Grade C). In cases of ES BOTs, lymphadenectomy is not recommended (Grade C). For ES BOTs, appendectomy is recommended only if there is a macroscopically pathological aspect to the appendix (Grade C). Restaging surgery is recommended in case of a serous BOT with a micropapillary aspect and an unsatisfactory inspection of the abdominal cavity during initial surgery (Grade C). Restaging surgery is recommended in cases of mucinous BOT if only a cystectomy has been performed or if the appendix has not been evaluated (Grade C). If restaging surgery is decided for an ES BOT, the following procedures should be performed: peritoneal cytology (grade C), omentectomy (there is no data in literature to recommend which type of omentectomy should be performed) (grade B), complete exploration of the abdominal cavity with peritoneal biopsies (grade C), visualization of the appendix +/- appendectomy in case of pathological macroscopic appearance (grade C) and unilateral adnexectomy in case of a mucinous BOT (grade C). In advanced stages of BOT it is not recommended to perform a lymphadenectomy as a routine procedure (Grade C). In cases of an advanced stage BOT, in a patient with a desire to fall pregnant, conservative treatment involving preservation of the uterus and all or part of the ovary may be proposed after a multidisciplinary meeting (Grade C). Second surgery aimed at removing all lesions, if not performed initially, is recommended in cases of advanced stage BOT (Grade C). It is not recommended to perform completion surgery after conservative treatment (preservation of the ovaries and the uterus) and after the achievement of fertility desire for a serous BOT (Grade B). After treatment for a BOT, follow-up beyond 5 years is recommended due to the median time to recurrence (Grade B). It is recommended that a systematic clinical examination be carried out during follow-up of a treated BOT (Grade B). In the particular case of an initial elevation of CA 125 levels, it is recommended to monitor CA 125 during follow up (Grade B). In cases treated conservatively (ovarian and uterine conservation), it is recommended to use endovaginal and transabdominal ultrasonography during the follow up period (Grade B). In the event of a recurrence of a BOT, in a woman of childbearing age, a conservative treatment strategy can again be proposed (Grade C). In the presence of non-invasive BOT implants, conservative treatment may be considered after a first non-invasive recurrence in women who wish to preserve their fertility (Grade C). Pelvic MRI is recommended after 12 weeks of amenorrhea in case of an undetermined adnexal mass and should be concluded with a diagnostic score (Grade C). The injection of gadolinium, in case of pregnancy, should be discussed on a case-by-case basis due to the proven risks for the foetus (Grade C). If feasible, a laparoscopic approach should be preferred during pregnancy (Grade C). A consultation with a specialist reproductive physician should be offered to patients with a BOT and of childbearing age (Grade C). It is recommended that patients be provided with full information on the risk of decreased ovarian reserve following to surgical treatment. It is recommended that the ovarian reserve be evaluated prior to surgical management of a suspected BOT (Grade C). When possible, a conservative surgical strategy is recommended to preserve fertility in women of childbearing age (Grade C). There is no specific data on the management of infertility following to conservative treatment of BOT. In case of durable infertility following to conservative treatment of BOT, a consultation with a specialist reproductive physician is required (Grade C). In the case of optimally treated BOT, there is no evidence in literature to contraindicate the use of Assisted Reproductive Techniques (ART). The use of hormonal contraception after serous or mucinous BOT is not contraindicated (Grade C). After treatment of a mucinous BOT, for women aged under 45 years, given the benefit of hormonal replacement therapy (HRT) on cardiovascular and bone risks, and the lack of hormone-sensitivity of mucinous BOTs, it is recommended to offer HRT (Grade C). After treatment of a mucinous BOT, for women over 45 years of age, there is no argument to contraindicate the use of HRT. HRT can be prescribed in case of a climacteric syndrome, as part of an individual benefit to risk assessment (Grade C).
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- 2021
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41. Prospective evaluation of the connected biofeedback EMY Kegel trainer in the management of stress urinary incontinence
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JOCHUM, Floriane, GARBIN, Olivier, GODET, Julien, RAGUENEAU, Mathilde, MEYER, Chantal, BILLECOCQ, Sylvie, LECOINTRE, Lise, AKLADIOS, Chérif, and HOST, Aline
- Abstract
•Perineal rehabilitation with EMY Kegel trainer might improve the quality of life.•An improvement of the urinary symptoms was also observed in this study.•The playfulness, practicality, and efficiency of the probe were positively rated by the patients.
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- 2021
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42. Laparoscopic Sacral Colpopexy: The "6-Points" Technique.
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Schaub, Marie, Lecointre, Lise, Faller, Emilie, Boisramé, Thomas, Baldauf, Jean-Jacques, Wattiez, Arnaud, and Akladios, Cherif Youssef
- Abstract
Study Objective: To illustrate laparoscopic sacral colpopexy for pelvic organ prolapse, a new method using a simplified mesh fixation technique, with only 6 fixing points.Design: Step-by-step explanation of the surgery using video (educative video). The video was approved by the local institutional review board.Setting: University Hospital of Strasbourg, France (Canadian Task Force Classification III).Patients: Women with multicompartment prolapse.Intervention: We first dissected the promontorium and vertically incise the posterior parietal peritoneum on the right pelvic sidewall up the pouch of Douglas. We then dissect the rectovaginal septum up to the anal cap, laterally exposing the puborectalis muscle on each side. Middle rectal vessels can be coagulated and cut without increasing the risk of digestive disorders (especially constipation), but it is preferable to conserve them if the space is sufficient for suture. Then, we dissect the vesicovaginal space and realized the subtotal hysterectomy. Finally, we realized the fastening of the anterior and posterior meshes. The particularity is that we performed only 6 points for fixing the meshes: 1 on the puborectalis muscle on each side without tension (to reduce the risk of mesh contracture, dyspareunia, and chronic pelvic pain), 1 for the fixing of the anterior mesh on the anterior vaginal wall at the level of the bladder neck, and 1 on each side of the cervix for the reconstitution of the pericervical ring gathering together the anterior mesh, the pubocervical fascia, and the insertion of the uterosacral ligament at the level of the cervix and the posterior mesh. The sixth stitch fastened 1 of 2 meshes to the anterior paravertebral ligament at the level of the sacral promontory. We finished with the peritonization.Main Results: The duration of surgery lasts approximately 120 minutes in well-experienced hands. Based on our experience the 6-point technique was relatively simple (few laparoscopic stiches) with few operative difficulties and was also associated with a low rate of reintervention.Conclusion: Surgical management of middle compartment prolapse could be performed quickly and efficiently under laparoscopy with the "6-points" technique. [ABSTRACT FROM AUTHOR]- Published
- 2017
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43. Recommendations for the surgical management of gynecological cancers during the COVID-19 pandemic - FRANCOGYN group for the CNGOF
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Akladios, Cherif, Azais, Henri, Ballester, Marcos, Bendifallah, Sofiane, Bolze, Pierre-Adrien, Bourdel, Nicolas, Bricou, Alexandre, Canlorbe, Geoffroy, Carcopino, Xavier, Chauvet, Pauline, Collinet, Pierre, Coutant, Charles, Dabi, Yohann, Dion, Ludivine, Gauthier, Tristan, Graesslin, Olivier, Huchon, Cyrille, Koskas, Martin, Kridelka, Frederic, Lavoue, Vincent, Lecointre, Lise, Mezzadri, Matthieu, Mimoun, Camille, Ouldamer, Lobna, Raimond, Emilie, and Touboul, Cyril
- Abstract
In the context of the COVID-19 pandemic, specific recommendations are required for the management of patients with gynecologic cancer.
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- 2020
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44. Two Surgical Techniques for Essure Device Ablation: The Hysteroscopic Way and the Laparoscopic Way by Salpingectomy with Tubal Interstitial Resection.
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Tissot, Marion, Petry, Solène, Lecointre, Lise, Faller, Emilie, Baldauf, Jean-Jacques, Akladios, Chérif, and Boisrame, Thomas
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Study Objective: To describe 2 different surgical techniques for Essure removal on the same patient: the hysteroscopic and laparoscopic techniques.Design: An educational video approved by the local institutional review board (Canadian Task Force classification III).Setting: A university hospital (University Hospital of Strasbourg, Strasbourg, France).Patient: A 46-year-old woman with many symptoms after Essure device implantation. An ultrasound found a right implant in the uterine cavity and a left intratubal implant.Interventions: The first step was the hysteroscopic removal of the right implant. We viewed the 2 internal and external spirals, allowing the gripping of the whole device without risking any fragmentation or tubal lesion. The second step was bilateral salpingectomy with resection of the left interstitial tubal portion. We longitudinally incised the antimesial edge of the fallopian tube 2 to 3 cm from the tubal serous to the implant contact. A circumferential incision was performed at the uterine horn to circumscribe the interstitial tubal portion. The implant was released from the surrounding tissue. It was gently pulled to completely extract it and avoid spiral fragmentation. Then, we performed a bilateral total salpingectomy. An X-ray of the implants and pelvis was performed to ensure complete removal of the device. We made an X-stitch in the uterine horn to avoid the risk of fistula.Conclusion: More and more patients are asking for the removal of their implants. The surgical technique has to be adapted to the location of the implants and has to allow their complete removal to avoid leaving fragments that can cause the persistence of side effects. [ABSTRACT FROM AUTHOR]- Published
- 2019
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45. Type B Laparoscopic Radical Trachelectomy with Uterine Artery Preservation for Stage IB1 Cervical Cancer.
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Gabriele, Victor, Lecointre, Lise, Faller, Emilie, and Akladios, Cherif
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Study Objective: Radical trachelectomy has emerged as a valuable fertility-preserving treatment option for young women with early-stage cervical cancer [1]. Laparoscopic radical trachelectomy performed by trained surgeons can be a feasible and safe therapeutic option as a fertility-sparing surgical technique [2,3]. To the best of our knowledge, this is the first time the total laparoscopic approach of radical trachelectomy is being published. In this video, rather than the description of the technique step by step, we show how to conserve uterine arteries even if the importance of such conservation is questionable.Design: A case report.Setting: A tertiary referral center in Strasbourg, France.Patient: A 37-year-old patient with no medical history who presented with stage IB1 invasive epidermoid cervical cancer.Intervention: In this video, we describe the fertility-sparing surgical procedure consisting of type B total laparoscopic radical trachelectomy with uterine artery preservation. The procedure consists of the following 10 steps: step 1, bilateral pelvic lymphadenectomy and opening of the para vesical fossa; step 2, opening of the pararectal fossa in between the ureter and the internal iliac artery on each side; step 3, ureteric dissection up to the ureteric canal; step 4, opening of the vesicouterine space and section of the vesicouterine ligament; step 5, posterior dissection with division of the uterosacral ligament approximately 20 mm from the uterine insertion; step 6, section of the descending branch of the uterine artery and skeletonization of the ascending branch up to the uterine isthmus level; step 7, trachelectomy with a monopolar hook; step 8, laparoscopic isthmovaginal stitches; step 9, laparoscopic cerclage; and step 10, peritoneal closure.Measurements and Main Results: The operative time was 420 minutes. The intraoperative blood loss was <200 mL. The operation was performed successfully with no intraoperative complications. The resection margins were safe. The patient was discharged on day 4. After 2 months, no late complications or recurrence were detected, and the patient had normal menstruation.Conclusion: Type B laparoscopic radical trachelectomy with uterine artery preservation appears to be a safe option for women who intend to maintain their desire for a future pregnancy. [ABSTRACT FROM AUTHOR]- Published
- 2019
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46. Predicting the difficulty of operative vaginal delivery by ultrasound measurement of fetal head station.
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Kasbaoui, Sidi, Séverac, François, Aïssi, Germain, Gaudineau, Adrien, Lecointre, Lise, Akladios, Chérif, Favre, Romain, Langer, Bruno, and Sananès, Nicolas
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FETAL imaging ,DELIVERY (Obstetrics) ,VAGINAL surgery ,MEDICAL records ,CONFIDENCE intervals ,BIRTH weight ,FETAL presentation ,FETAL ultrasonic imaging ,HEAD ,LONGITUDINAL method ,OBSTETRICAL extraction ,OBSTETRICAL forceps ,PERINEUM ,PROBABILITY theory ,PREDICTIVE tests ,PARITY (Obstetrics) - Abstract
Background: Clinical assessment of fetal head station is difficult and subjective; it is mandatory before attempting operative vaginal delivery.Objective: The principal objective of our study was to assess whether measurement of the perineum-to-skull ultrasound distance was predictive of a difficult operative vaginal delivery. Secondary objectives included evaluation of the interobserver reproducibility of perineum-to-skull ultrasound distance and comparison of this measurement and digital examination in predicting a difficult operative delivery.Study Design: This was a prospective cohort study including all cases of operative vaginal deliveries in singleton pregnancies in cephalic presentation >34 weeks' gestation, from 2012 through 2015. All data were entered prospectively in a medical record system specially devised to meet the requirements of this study.Results: Of the 659 patients in whom perineum-to-skull ultrasound distance was measured prior to operative vaginal delivery, 120 (18%) met the composite criterion for a difficult extraction. Perineum-to-skull ultrasound distance measurement of ≥40 mm was significantly associated with the occurrence of a difficult extraction based on the composite criterion, after adjustment for parity, presentation type, and fetal macrosomia (odds ratio, 2.38; 95% confidence interval, 1.51-3.74; P = .0002). The intraclass correlation coefficient between the perineum-to-skull ultrasound distance measured by the first operator and that measured by the second operator was 0.96 (95% confidence interval, 0.95-0.97; P < .0001). Based on the receiver operating characteristic curve analyses, perineum-to-skull ultrasound distance was a more accurate predictor of difficult operative delivery than digital vaginal examination (P = .036).Conclusion: Measurement of the perineum-fetal skull ultrasound distance is a reproducible and predictive index of the difficulty of instrumental extraction. Ultrasound is a useful supplementary tool to the usual clinical findings. [ABSTRACT FROM AUTHOR]- Published
- 2017
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