Search

ABSTRACTCellulose nitrate artifacts from the collections of the Queen’s University Master of Art Conservation Program and Glanmore National Historic Site were examined and treated by graduate students in the Master of Art Conservation Program at Queen’s. Each object was in a varied state of degradation with unique condition problems. Under the supervision of the artifacts conservation professor, graduate students identified the materials constituting their objects and tested various treatment methods for consolidation and structural repair. Paraloid® B-67 in n-butanol and Aquazol® resins in isopropanol and distilled water were found to be effective in different roles, depending on the object and its state of degradation. This paper will discuss the factors that influenced decision-making for each object, with the aim of expanding interventive treatment strategies for cellulose nitrate objects.

Perspectives When Ashley Flowers was a child, she wanted to be a defense attorney. Prawat's husband composed the theme song, doing his best to interpret what Flowers meant when she asked for it to be "pingier"; Flowers's younger brother, David, then a college student, took on the editing the following summer. When it comes to true crime podcasts, though (or even shows like CSI), they clearly draw more women - one 2018 study coauthored by Boling found 73 percent of true crime podcast listeners were women. Flowers also gave Dalton final approval over what would be included; the true crime podcast The Murder Sheet later described Red Ball as "badly written 'copoganda.'" In some episodes of Crime Junkie, law enforcement comes off badly. [Extracted from the article]

The article looks at the failure of U.S. military in fixing violence against women by making reference to airman Natasha Aposhian who was shot dead by another airman Julian Torres after being in a relationship.

The article offers information on the blogger Clemmie Hooper, including her parenting under the influence of social media; Clemmie's mothering, her outfits, her weight and the decor of her home; and also mentions Mom 2.0 Summit, a professional conference for parenting influencers.

Acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic cell transplantation (HCT) is a primary cause of nonrelapse mortality and a major barrier to successful transplant outcomes. Itacitinib is a Janus kinase (JAK)1–selective inhibitor that has demonstrated efficacy in preclinical models of aGVHD. We report results from the first registered study of a JAK inhibitor in patients with aGVHD. This was an open-label phase 1 study enrolling patients aged ≥18 years with first HCT from any source who developed grade IIB to IVD aGVHD. Patients with steroid-naive or steroid-refractory aGVHD were randomized 1:1 to itacitinib 200 mg or 300 mg once daily plus corticosteroids. The primary endpoint was safety and tolerability; day 28 overall response rate (ORR) was the main secondary endpoint. Twenty-nine patients (200 mg, n = 14; 300 mg, n = 15) received ≥1 dose of itacitinib and were included in safety and efficacy assessments. One dose-limiting toxicity was reported (grade 3 thrombocytopenia attributed to GVHD progression in a patient receiving 300 mg itacitinib with preexisting thrombocytopenia). The most common nonhematologic treatment-emergent adverse event was diarrhea (48.3%, n = 14); anemia occurred in 11 patients (38%). ORR on day 28 for all patients in the 200-mg and 300-mg groups was 78.6% and 66.7%, respectively. Day 28 ORR was 75.0% for patients with treatment-naive aGVHD and 70.6% in those with steroid-refractory aGVHD. All patients receiving itacitinib decreased corticosteroid use over time. In summary, itacitinib was well tolerated and demonstrated encouraging efficacy in patients with steroid-naive or steroid-refractory aGVHD, warranting continued clinical investigations. This trial was registered at www.clinicaltrials.gov as #NCT02614612.

Acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic cell transplantation (HCT) is a primary cause of nonrelapse mortality and a major barrier to successful transplant outcomes. Itacitinib is a Janus kinase (JAK)1–selective inhibitor that has demonstrated efficacy in preclinical models of aGVHD. We report results from the first registered study of a JAK inhibitor in patients with aGVHD. This was an open-label phase 1 study enrolling patients aged ≥18 years with first HCT from any source who developed grade IIB to IVD aGVHD. Patients with steroid-naive or steroid-refractory aGVHD were randomized 1:1 to itacitinib 200 mg or 300 mg once daily plus corticosteroids. The primary endpoint was safety and tolerability; day 28 overall response rate (ORR) was the main secondary endpoint. Twenty-nine patients (200 mg, n = 14; 300 mg, n = 15) received ≥1 dose of itacitinib and were included in safety and efficacy assessments. One dose-limiting toxicity was reported (grade 3 thrombocytopenia attributed to GVHD progression in a patient receiving 300 mg itacitinib with preexisting thrombocytopenia). The most common nonhematologic treatment-emergent adverse event was diarrhea (48.3%, n = 14); anemia occurred in 11 patients (38%). ORR on day 28 for all patients in the 200-mg and 300-mg groups was 78.6% and 66.7%, respectively. Day 28 ORR was 75.0% for patients with treatment-naive aGVHD and 70.6% in those with steroid-refractory aGVHD. All patients receiving itacitinib decreased corticosteroid use over time. In summary, itacitinib was well tolerated and demonstrated encouraging efficacy in patients with steroid-naive or steroid-refractory aGVHD, warranting continued clinical investigations. This trial was registered at www.clinicaltrials.govas #NCT02614612.

The article focuses on miscellaneous information on topics including painter Loie Hollowell, hospitality industry and sculptor Huma Bhabha. Topics discussed include exhibition show "Holyfuck" by Hollowell, hospitality industry which has been offering curatorial programs exhibiting art exhibitions such as "Rain Room" and figures in art as character decribed by Bhabha.

The article focuses on career of several woman artists, creators, and advocates; including information on performance of actress Kaitlyn Dever in film "Booksmart;" Tony Awards to stage director Rachel Chavkin; and gun violence policy by Jacinda Ardern, Prime Minister of New Zealand.

In this article, several women celebrities including Nicole Kidman, Scarlett Johansson, and Natalie Portman shares their success story in Hollywood, California motion picture industry.

The article offers information on author and environmental activist Naomi Klein, her efforts for climate change mitigation and her book "On Fire: The (Burning) Case for a Green New Deal."

The article offers information on architect Neri Oxman, her design Aguahoja I, and dating hedge funder Bill Ackman.

The article offers wok and life of Hope Solo, an American soccer player who has now become a vocal advocate for equal pay in women's soccer.

This article discusses the backlash to mom-shaming, the practice of women being criticized for their child-rearing behaviors.

The mantle sources of mid-ocean ridge basalts beneath the Indian and Pacific oceans have distinct isotopic compositions with a long-accepted boundary at the Australian–Antarctic Discordance along the Southeast Indian Ridge. This boundary has been widely used to place constraints on large-scale patterns of mantle flow and composition in the Earth’s upper mantle. Sampling between the Indian and Pacific ridges, however, has been lacking, especially along the remote 2,000 km expanse of the Australian–Antarctic Ridge. Here we present Sr, Nd, Hf and Pb isotope data from this region that show the Australian–Antarctic Ridge has isotopic compositions distinct from both the Pacific and Indian mantle domains. These data define a separate Zealandia–Antarctic domain that appears to have formed in response to the deep mantle upwelling and ensuing volcanism that led to the break-up of Gondwana 90 million years ago, and currently persists at the margins of the Antarctic continent. The relatively shallow depths of the Australian–Antarctic Ridge may be the result of this deep mantle upwelling. Large offset transforms to the east may be the boundary with the Pacific domain.

In this paper we consider a much-quoted phrase published by the essayist Charles Lamb (1775–1834) in the London Magazinein 1822 about a desirable quality in books: that they should be ‘strong-backed and neat-bound’. We identify meanings of modifier neatas evidenced by different communities of practice in early nineteenth-century newspapers, and in particular we present meanings of neatas used in certain Quaker writings known to have been read with approval by Lamb. By this method we assemble a series of nuanced meanings that the phrase neat-boundwould have conveyed to contemporary readers – specifically, the readership of the London Magazine.

The article profiles Jane Mayer, who is one of the most prominent investigative reporters in the U.S.

Introduction:Corticosteroids (CS) are the standard first-line treatment for patients (pts) with chronic graft-versus-host disease (cGvHD), but pts can be unresponsive or become refractory to or dependent on CS (SR/D).Ruxolitinib (RUX), a JAK1/2 inhibitor, is approved for the treatment of pts ≥12 years of age with SR/D-cGVHD, based on the primary outcomes from the randomized, phase III REACH3 (NCT03112603) study, which demonstrated the superior efficacy of RUX vs best available treatment (BAT) in pts with SR/D-cGVHD. Here, we present the final, long-term efficacy and safety outcomes from REACH3.

The article offers information on the wildfire in the Amazon rain forest and Australia, includes views of Gerardo Huertas, who leads disaster operations and risk reduction worldwide for the global nonprofit World Animal Protection, on issue.

The article features several women executives including photographer Deana Lawson, feminist artist Judy Chicago and art gallery owner Bridget Donahue.

The article focuses on the American actress and former fashion model Mia Farrow, who was nominated for several awards following her role as Rosemary in the film "Rosemary's Baby," and had gained recognition for the television soap opera "Peyton Place."

The article reflects on Cara Mund, who was crowned Miss America 2018 in Atlantic City, New Jersey, mentions the positive impact being made by the Miss America Organization (MAO) such as providing scholarships, and presents the views of Gretchen Carlson, chairwomen of MAO, on the competition.

The article features broadcast journalist Ainsley Earhardt with topics including her book "The Light Within Me: An Inspirational Memoir," her contribution on the increase of television program "Fox & Friend" rating, and her support to U.S. President Donald Trump.

The author shares her experience of how the gloom of being pregnant was a weight instead of a thought, and was the same to how she had felt after two miscarriages.

The article talks about women artists including work of Toyin Ojih Odutola and Rujeko Hockley presented at Manhattan's Whitney Museum; use of art by Shirin Neshat for depicting social issues; and Paula Cooper Gallery's first show for the Student Mobilization Committee to End the War in Vietnam.

The article reviews the television program "She's Gotta Have It," starring DeWanda Wise, the theatrical production "Mean Girls" to premier on October 31, 2017 at Washington, DC's National Theatre, as well as the book "Manhattan Beach" by Jennifer Egan.

The article offers information on women executives in technology including Belinda Johnson of Airbnb, Jess Lee of Sequoia Capital, and Kimberly Bryant of nonprofit Black Girls CODE.

The author looks at the contemporary art revolution in China by discussing topics including views of Max Mara Creative Director Ian Griffiths, on underground art, and teaching of fashion design by Griffiths at London's Kingston University.

The article offers information on six top models including Bella Hadid, Hailey Baldwin and Jasmine Tookes, who have several things in common like good genes, professional discipline, and the kind of star power.

The article discusses the impact of fat intake on human body; suggests taking low-fat meals; and reports that monounsaturated fats in nuts and olive oil had health advantages while most other fats were best consumed in moderation.

The article focuses on the roles and experiences of actors Thandie Newton in television series Westworld, Issa Rae in television series Insecure and Mandy Moore in television series This Is Us.

The article presents career profile of several freelance artists including painter Chloe Wise, puppet maker Laurie Simmons and videographer Pipilotti Rist, detailing their individual passion for their craft, interest in freelance arts and passion for innovative art and technology.

The processes that lead to the fourfold variation in arc-averaged compositions of mafic arc lavas remain controversial. Control by the mantle-wedge thermal structure is supported by chemical correlations with the thickness of the underlying arc crust, which affects the thermal state of the wedge. Control by down-going slab temperature is supported by correlations with the slab thermal parameter. The Chilean Southern Volcanic Zone provides a test of these hypotheses. Here we use chemical data to demonstrate that the Southern Volcanic Zone and global arc averages define the same chemical trends, both among elements and between elements and crustal thickness. But in contrast to the global arc system, the Southern Volcanic Zone is built on crust of variable thickness with a constant slab thermal parameter. This natural experiment, along with a set of numerical simulations, shows that global arc compositional variability is dominated by different extents of melting that are controlled by the thermal structure of the mantle wedge. Slab temperatures play a subordinate role. Variations in the subducting slab’s fluid flux and sediment compositions, as well as mantle-wedge heterogeneities, produce second-order effects that are manifested as distinctive trace element and isotopic signatures; these can be more clearly elucidated once the importance of wedge thermal structure is recognized.

The article presents several updates related to the U.S. film and music industry and newly released books including selection of actor Joe Alwyn for the film "Billy Lynn's Long Halftime Walk" and information on the book "The Mothers" by Brit Bennett.

The article profiles several women executives in technology industry including Marcela Sapone, cofounder and chief executive officer (CEO) of technology company Hello Alfred, Whitney Wolfe, founder and CEO of dating app Bumble, and Jen Fitzpatrick, vice president of web mapping app Google Maps.

The article discusses the sexual harassmen in the restaurant industry, highlighting the pastry sexual harassment case filed by pastry chef Kate Burnham against Weslodge, an eatery in Toronto, Ontario and a study revealing that male chefs are regarded as control-freak workaholics.

Sea level changes associated with Pleistocene glacial cycles have been hypothesized to modulate melt production and hydrothermal activity at ocean ridges, yet little is known about fluctuations in hydrothermal circulation on time scales longer than a few millennia. We present a high‐resolution record of hydrothermal activity over the past 50 ka using elemental flux data from a new sediment core from the Mir zone of the TAG hydrothermal field at 26°N on the Mid‐Atlantic Ridge. Mir sediments reveal sixfold to eightfold increases in hydrothermal iron and copper deposition during the Last Glacial Maximum, followed by a rapid decline during the sea level rise associated with deglaciation. Our results, along with previous observations from Pacific and Atlantic spreading centers, indicate that rapid sea level changes influence hydrothermal output on mid‐ocean ridges. Thus, climate variability may discretize volcanic processing of the solid Earth on millennial time scales and subsequently stimulate variability in biogeochemical interactions with volcanic systems. New TAG sediment core used to examine hydrothermal response to sea level changeHydrothermal Fe and Cu deposition peak during Last Glacial Maximum and decline during deglaciationGlobal hydrothermal Fe flux and subsequent carbon export may vary across glacial cycles

The article reviews an art exhibition featuring work of artist Petra Cortright held at UTA Artist Space in Los Angeles, California as of June 2018.

A personal narrative is presented in which the author describes his travel to Teton Village in Jackson Hole valley.

The article offers information on 14 women artists in New York City who are ruling the art world including painter Carmen Herrera, visual artist Joan Jones, and an American contemporary artist Xaviera Simmons.

The article focuses on the low sexual desire in women, the approval of the drug flibanserin for the treatment of female desire and the division among the activists over the support for the drug.