Search

Your search keyword '"Landras, Caroline"' showing total 1 results
Start Over Author "Landras, Caroline" Database Supplemental Index

Refine your results

1 results on '"Landras, Caroline"'

1. New tetrahydronaphthalene derivatives as combined thromboxane receptor antagonists and thromboxane synthase inhibitors

Author

Cimetière, Bernard, Dubuffet, Thierry, Landras, Caroline, Descombes, Jean-Jacques, Simonet, Serge, Verbeuren, Tony J., and Lavielle, Gilbert

Abstract

A pyridine group was linked to the tetrahydronaphthalene moiety of the derivatives described in the preceding paper, to afford new combined thromboxane receptor (TP-receptor) antagonists and synthase inhibitors. The most interesting compound 2finhibits TXA2 synthase with an IC50 value of 0.64 μM and the aggregation of human platelets with an IC50 value of 0.063 μM and shows a long duration of action in different species after oral administration.

Published
1998
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results