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2. Characterization of RNA aptamers against SRP19 protein having sequences different from SRP RNA

Author

Haraguchi, Yuki, Kuwasako, Kanako, Muto, Yutaka, Bessho, Yoshitaka, Nishimoto, Madoka, Yokoyama, Shigeyuki, Kanai, Akio, Kawai, Gota, and Sakamoto, Taiichi

Abstract

SELEX is a conventional method to obtain high affinity nucleic acids to target molecules. In this study, high affinity RNA molecules against SRP19 protein were selected by using a randomized library. The primary and predicted secondary structures of the aptamers are different from those of S-domain RNA which is the natural target of SRP19 protein. Comparison of structural features between S-domain RNA and aptamers might enhance our understanding on RNA-protein interaction.

Published
2009
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