341 results on '"Kivimäki P"'
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2. Dementia prevention, intervention, and care: 2024 report of the Lancetstanding Commission
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Livingston, Gill, Huntley, Jonathan, Liu, Kathy Y, Costafreda, Sergi G, Selbæk, Geir, Alladi, Suvarna, Ames, David, Banerjee, Sube, Burns, Alistair, Brayne, Carol, Fox, Nick C, Ferri, Cleusa P, Gitlin, Laura N, Howard, Robert, Kales, Helen C, Kivimäki, Mika, Larson, Eric B, Nakasujja, Noeline, Rockwood, Kenneth, Samus, Quincy, Shirai, Kokoro, Singh-Manoux, Archana, Schneider, Lon S, Walsh, Sebastian, Yao, Yao, Sommerlad, Andrew, and Mukadam, Naaheed
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- 2024
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3. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
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Schumacher, Austin E, Kyu, Hmwe Hmwe, Aali, Amirali, Abbafati, Cristiana, Abbas, Jaffar, Abbasgholizadeh, Rouzbeh, Abbasi, Madineh Akram, Abbasian, Mohammadreza, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdelwahab, Ahmed, Abdollahi, Mohammad, Abdoun, Meriem, Abdullahi, Auwal, Abdurehman, Ame Mehadi, Abebe, Mesfin, Abedi, Aidin, Abedi, Armita, Abegaz, Tadesse M, Abeldaño Zuñiga, Roberto Ariel, Abhilash, E S, Abiodun, Olugbenga Olusola, Aboagye, Richard Gyan, Abolhassani, Hassan, Abouzid, Mohamed, Abreu, Lucas Guimarães, Abrha, Woldu Aberhe, Abrigo, Michael R M, Abtahi, Dariush, Abu Rumeileh, Samir, Abu-Rmeileh, Niveen ME, Aburuz, Salahdein, Abu-Zaid, Ahmed, Acuna, Juan Manuel, Adair, Tim, Addo, Isaac Yeboah, Adebayo, Oladimeji M, Adegboye, Oyelola A, Adekanmbi, Victor, Aden, Bashir, Adepoju, Abiola Victor, Adetunji, Charles Oluwaseun, Adeyeoluwa, Temitayo Esther, Adeyomoye, Olorunsola Israel, Adha, Rishan, Adibi, Amin, Adikusuma, Wirawan, Adnani, Qorinah Estiningtyas Sakilah, Adra, Saryia, Afework, Abel, Afolabi, Aanuoluwapo Adeyimika, Afraz, Ali, Afyouni, Shadi, Afzal, Saira, Agasthi, Pradyumna, Aghamiri, Shahin, Agodi, Antonella, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Muayyad M, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadzade, Amir Mahmoud, Ahmadzade, Mohadese, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Luai A, Ahmed, Muktar Beshir, Ahmed, Syed Anees, Ajami, Marjan, Aji, Budi, Ajumobi, Olufemi, Akalu, Gizachew Taddesse, Akara, Essona Matatom, Akinosoglou, Karolina, Akkala, Sreelatha, Akyirem, Samuel, Al Hamad, Hanadi, Al Hasan, Syed Mahfuz, Al Homsi, Ammar, Al Qadire, Mohammad, Ala, Moein, Aladelusi, Timothy Olukunle, AL-Ahdal, Tareq Mohammed Ali, Alalalmeh, Samer O, Al-Aly, Ziyad, Alam, Khurshid, Alam, Manjurul, Alam, Zufishan, Al-amer, Rasmieh Mustafa, Alanezi, Fahad Mashhour, Alanzi, Turki M, Albashtawy, Mohammed, AlBataineh, Mohammad T, Aldridge, Robert W, Alemi, Sharifullah, Al-Eyadhy, Ayman, Al-Gheethi, Adel Ali Saeed, Alhabib, Khalid F, Alhalaiqa, Fadwa Alhalaiqa Naji, Al-Hanawi, Mohammed Khaled, Ali, Abid, Ali, Akhtar, Ali, Beriwan Abdulqadir, Ali, Hassam, Ali, Mohammed Usman, Ali, Rafat, Ali, Syed Shujait Shujait, Ali, Zahid, Alian Samakkhah, Shohreh, Alicandro, Gianfranco, Alif, Sheikh Mohammad, Aligol, Mohammad, Alimi, Rasoul, Aliyi, Ahmednur Adem, Al-Jumaily, Adel, Aljunid, Syed Mohamed, Almahmeed, Wael, Al-Marwani, Sabah, Al-Maweri, Sadeq Ali Ali, Almazan, Joseph Uy, Al-Mekhlafi, Hesham M, Almidani, Omar, Alomari, Mahmoud A, Alonso, Nivaldo, Alqahtani, Jaber S, Alqutaibi, Ahmed Yaseen, Al-Sabah, Salman Khalifah, Altaf, Awais, Al-Tawfiq, Jaffar A, Altirkawi, Khalid A, Alvi, Farrukh Jawad, Alwafi, Hassan, Al-Worafi, Yaser Mohammed, Aly, Hany, Alzoubi, Karem H, Amare, Azmeraw T, Ameyaw, Edward Kwabena, Amhare, Abebe Feyissa, Amin, Tarek Tawfik, Amindarolzarbi, Alireza, Aminian Dehkordi, Javad, Amiri, Sohrab, Amu, Hubert, Amugsi, Dickson A, Amzat, Jimoh, Ancuceanu, Robert, Anderlini, Deanna, Andrade, Pedro Prata, Andrei, Catalina Liliana, Andrei, Tudorel, Angappan, Dhanalakshmi, Anil, Abhishek, Anjum, Afifa, Antony, Catherine M, Antriyandarti, Ernoiz, Anuoluwa, Iyadunni Adesola, Anwar, Sumadi Lukman, Anyasodor, Anayochukwu Edward, Appiah, Seth Christopher Yaw, Aqeel, Muhammad, Arabloo, Jalal, Arabzadeh Bahri, Razman, Arab-Zozani, Morteza, Arafat, Mosab, Araújo, Ana Margarida, Aravkin, Aleksandr Y, Aremu, Abdulfatai, Ariffin, Hany, Aripov, Timur, Armocida, Benedetta, Arooj, Mahwish, Artamonov, Anton A, Artanti, Kurnia Dwi, Arulappan, Judie, Aruleba, Idowu Thomas, Aruleba, Raphael Taiwo, Arumugam, Ashokan, Asaad, Malke, Asgary, Saeed, Ashemo, Mubarek Yesse, Ashraf, Muhammad, Asika, Marvellous O, Athari, Seyyed Shamsadin, Atout, Maha Moh'd Wahbi, Atreya, Alok, Attia, Sameh, Aujayeb, Avinash, Avan, Abolfazl, Awotidebe, Adedapo Wasiu, Ayala Quintanilla, Beatriz Paulina, Ayanore, Martin Amogre, Ayele, Getnet Melaku, Ayuso-Mateos, Jose L, Ayyoubzadeh, Seyed Mohammad, Azadnajafabad, Sina, Azhar, Gulrez Shah, Aziz, Shahkaar, Azzam, Ahmed Y, Babashahi, Mina, Babu, Abraham Samuel, Badar, Muhammad, Badawi, Alaa, Badiye, Ashish D, Baghdadi, Soroush, Bagheri, Nasser, Bagherieh, Sara, Bah, Sulaiman, Bahadorikhalili, Saeed, Bai, Jianjun, Bai, Ruhai, Baker, Jennifer L, Bakkannavar, Shankar M, Bako, Abdulaziz T, Balakrishnan, Senthilkumar, Balogun, Saliu A, Baltatu, Ovidiu Constantin, Bam, Kiran, Banach, Maciej, Bandyopadhyay, Soham, Banik, Biswajit, Banik, Palash Chandra, Bansal, Hansi, Barati, Shirin, Barchitta, Martina, Bardhan, Mainak, Barker-Collo, Suzanne Lyn, Barone-Adesi, Francesco, Barqawi, Hiba Jawdat, Barr, Ronald D, Barrero, Lope H, Basharat, Zarrin, Bashir, Asma'u I J, Bashiru, Hameed Akande, Baskaran, Pritish, Basnyat, Buddha, Bassat, Quique, Basso, João Diogo, Basu, Saurav, Batra, Kavita, Batra, Ravi, Baune, Bernhard T, Bayati, Mohsen, Bayileyegn, Nebiyou Simegnew, Beaney, Thomas, Bedi, Neeraj, Begum, Tahmina, Behboudi, Emad, Behnoush, Amir Hossein, Beiranvand, Maryam, Bejarano Ramirez, Diana Fernanda, Belgaumi, Uzma Iqbal, Bell, Michelle L, Bello, Aminu K, Bello, Muhammad Bashir, Bello, Olorunjuwon Omolaja, Belo, Luis, Beloukas, Apostolos, Bendak, Salaheddine, Bennett, Derrick A, Bensenor, Isabela M, Benzian, Habib, Berezvai, Zombor, Berman, Adam E, Bermudez, Amiel Nazer C, Bettencourt, Paulo J G, Beyene, Habtamu B, Beyene, Kebede A, Bhagat, Devidas S, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhalla, Ashish, Bhandari, Dinesh, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhardwaj, Prarthna V, Bhargava, Ashish, Bhaskar, Sonu, Bhat, Vivek, Bhatti, Gurjit Kaur, Bhatti, Jasvinder Singh, Bhatti, Manpreet S, Bhatti, Rajbir, Bhutta, Zulfiqar A, Bikbov, Boris, Binmadi, Nada, Bintoro, Bagas Suryo, Biondi, Antonio, Bisignano, Catherine, Bisulli, Francesca, Biswas, Atanu, Biswas, Raaj Kishore, Bitaraf, Saeid, Bjørge, Tone, Bleyer, Archie, Boampong, Mary Sefa, Bodolica, Virginia, Bodunrin, Aadam Olalekan, Bolarinwa, Obasanjo Afolabi, Bonakdar Hashemi, Milad, Bonny, Aime, Bora, Kaustubh, Bora Basara, Berrak, Borodo, Safiya Bala, Borschmann, Rohan, Botero Carvajal, Alejandro, Bouaoud, Souad, Boudalia, Sofiane, Boyko, Edward J, Bragazzi, Nicola Luigi, Braithwaite, Dejana, Brenner, Hermann, Britton, Gabrielle, Browne, Annie J, Brunoni, Andre R, Bulamu, Norma B, Bulto, Lemma N, Buonsenso, Danilo, Burkart, Katrin, Burns, Richard A, Burugina Nagaraja, Sharath, Busse, Reinhard, Bustanji, Yasser, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cai, Tianji, Calina, Daniela, Cámera, Luis Alberto, Campos, Luciana Aparecida, Campos-Nonato, Ismael R, Cao, Chao, Cardenas, Carlos Alberto, Cárdenas, Rosario, Carr, Sinclair, Carreras, Giulia, Carrero, Juan J, Carugno, Andrea, Carvalho, Felix, Carvalho, Márcia, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Catalá-López, Ferrán, Catapano, Alberico L, Cattaruzza, Maria Sofia, Caye, Arthur, Cederroth, Christopher R, Cembranel, Francieli, Cenderadewi, Muthia, Cercy, Kelly M, Cerin, Ester, Cevik, Muge, Chacón-Uscamaita, Pamela R Uscamaita, Chahine, Yaacoub, Chakraborty, Chiranjib, Chan, Jeffrey Shi Kai, Chang, Chin-Kuo, Charalampous, Periklis, Charan, Jaykaran, Chattu, Vijay Kumar, Chatzimavridou-Grigoriadou, Victoria, Chavula, Malizgani Paul, Cheema, Huzaifa Ahmad, Chen, An-Tian, Chen, Haowei, Chen, Lingxiao, Chen, Meng Xuan, Chen, Simiao, Cherbuin, Nicolas, Chew, Derek S, Chi, Gerald, Chirinos-Caceres, Jesus Lorenzo, Chitheer, Abdulaal, Cho, So Mi Jemma, Cho, William C S, Chong, Bryan, Chopra, Hitesh, Choudhary, Rahul, Chowdhury, Rajiv, Chu, Dinh-Toi, Chukwu, Isaac Sunday, Chung, Eric, Chung, Eunice, Chung, Sheng-Chia, Cini, Karly I, Clark, Cain C T, Coberly, Kaleb, Columbus, Alyssa, Comfort, Haley, Conde, Joao, Conti, Sara, Cortesi, Paolo Angelo, Costa, Vera Marisa, Cousin, Ewerton, Cowden, Richard G, Criqui, Michael H, Cruz-Martins, Natália, Culbreth, Garland T, Cullen, Patricia, Cunningham, Matthew, da Silva e Silva, Daniel, Dadana, Sriharsha, Dadras, Omid, Dai, Zhaoli, Dalal, Koustuv, Dalli, Lachlan L, Damiani, Giovanni, D'Amico, Emanuele, Daneshvar, Sara, Darwesh, Aso Mohammad, Das, Jai K, Das, Saswati, Dash, Nihar Ranjan, Dashti, Mohsen, Dávila-Cervantes, Claudio Alberto, Davis Weaver, Nicole, Davletov, Kairat, De Leo, Diego, Debele, Aklilu Tamire, Degenhardt, Louisa, Dehbandi, Reza, Deitesfeld, Lee, Delgado-Enciso, Ivan, Delgado-Ortiz, Laura, Demant, Daniel, Demessa, Berecha Hundessa, Demetriades, Andreas K, Deng, Xinlei, Denova-Gutiérrez, Edgar, Deribe, Kebede, Dervenis, Nikolaos, Des Jarlais, Don C, Desai, Hardik Dineshbhai, Desai, Rupak, Deuba, Keshab, Devanbu, Vinoth Gnana Chellaiyan, Dey, Sourav, Dhali, Arkadeep, Dhama, Kuldeep, Dhimal, Mandira Lamichhane, Dhimal, Meghnath, Dhingra, Sameer, Dias da Silva, Diana, Diaz, Daniel, Dima, Adriana, Ding, Delaney D, Dirac, M Ashworth, Dixit, Abhinav, Dixit, Shilpi Gupta, Do, Thanh Chi, Do, Thao Huynh Phuong, do Prado, Camila Bruneli, Dodangeh, Masoud, Dokova, Klara Georgieva, Dolecek, Christiane, Dorsey, E Ray, dos Santos, Wendel Mombaque, Doshi, Rajkumar, Doshmangir, Leila, Douiri, Abdel, Dowou, Robert Kokou, Driscoll, Tim Robert, Dsouza, Haneil Larson, Dube, John, Dumith, Samuel C, Dunachie, Susanna J, Duncan, Bruce B, Duraes, Andre Rodrigues, Duraisamy, Senbagam, Durojaiye, Oyewole Christopher, Dutta, Sulagna, Dzianach, Paulina Agnieszka, Dziedzic, Arkadiusz Marian, Ebenezer, Oluwakemi, Eboreime, Ejemai, Ebrahimi, Alireza, Echieh, Chidiebere Peter, Ed-Dra, Abdelaziz, Edinur, Hisham Atan, Edvardsson, David, Edvardsson, Kristina, Efendi, Defi, Efendi, Ferry, Eghdami, Shayan, Eikemo, Terje Andreas, Eini, Ebrahim, Ekholuenetale, Michael, Ekpor, Emmanuel, Ekundayo, Temitope Cyrus, El Arab, Rabie Adel, El Morsi, Doaa Abdel Wahab, El Sayed Zaki, Maysaa, El Tantawi, Maha, Elbarazi, Iffat, Elemam, Noha Mousaad, Elgar, Frank J, Elgendy, Islam Y, ElGohary, Ghada Metwally Tawfik, Elhabashy, Hala Rashad, Elhadi, Muhammed, Elmeligy, Omar Abdelsadek Abdou, Elshaer, Mohammed, Elsohaby, Ibrahim, Emami Zeydi, Amir, Emamverdi, Mehdi, Emeto, Theophilus I, Engelbert Bain, Luchuo, Erkhembayar, Ryenchindorj, Eshetie, Tesfahun C, Eskandarieh, Sharareh, Espinosa-Montero, Juan, Estep, Kara, Etaee, Farshid, Eze, Ugochukwu Anthony, Fabin, Natalia, Fadaka, Adewale Oluwaseun, Fagbamigbe, Adeniyi Francis, Fahimi, Saman, Falzone, Luca, Farinha, Carla Sofia e Sá, Faris, MoezAlIslam Ezzat Mahmoud, Farjoud Kouhanjani, Mohsen, Faro, Andre, Farrokhpour, Hossein, Fatehizadeh, Ali, Fattahi, Hamed, Fauk, Nelsensius Klau, Fazeli, Pooria, Feigin, Valery L, Fekadu, Ginenus, Fereshtehnejad, Seyed-Mohammad, Feroze, Abdullah Hamid, Ferrante, Daniela, Ferrara, Pietro, Ferreira, Nuno, Fetensa, Getahun, Filip, Irina, Fischer, Florian, Flavel, Joanne, Flaxman, Abraham D, Flor, Luisa S, Florin, Bobirca Teodor, Folayan, Morenike Oluwatoyin, Foley, Kristen Marie, Fomenkov, Artem Alekseevich, Force, Lisa M, Fornari, Carla, Foroutan, Behzad, Foschi, Matteo, Francis, Kate Louise, Franklin, Richard Charles, Freitas, Alberto, Friedman, Joseph, Friedman, Sara D, Fukumoto, Takeshi, Fuller, John E, Gaal, Peter Andras, Gadanya, Muktar A, Gaihre, Santosh, Gaipov, Abduzhappar, Gakidou, Emmanuela, Galali, Yaseen, Galehdar, Nasrin, Gallus, Silvano, Gan, Quan, Gandhi, Aravind P, Ganesan, Balasankar, Garg, Jalaj, Gau, Shuo-Yan, Gautam, Prem, Gautam, Rupesh K, Gazzelloni, Federica, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Gebremariam, Tesfay Brhane, Gerema, Urge, Getachew, Motuma Erena, Getachew, Tamirat, Gething, Peter W, Ghafourifard, Mansour, Ghahramani, Sulmaz, Ghailan, Khalid Yaser, Ghajar, Alireza, Ghanbarnia, Mohammad Javad, Ghasemi, MohammadReza, Ghasemzadeh, Afsaneh, Ghassemi, Fariba, Ghazy, Ramy Mohamed, Ghimire, Sailaja, Gholamian, Asadollah, Gholamrezanezhad, Ali, Ghorbani Vajargah, Pooyan, Ghozali, Ghozali, Ghozy, Sherief, Ghuge, Arun Digambarrao, Gialluisi, Alessandro, Gibson, Ruth Margaret, Gil, Artyom Urievich, Gill, Paramjit Singh, Gill, Tiffany K, Gillum, Richard F, Ginindza, Themba G, Girmay, Alem, Glasbey, James C, Gnedovskaya, Elena V, Göbölös, Laszlo, Goel, Amit, Goldust, Mohamad, Golechha, Mahaveer, Goleij, Pouya, Golestanfar, Arefeh, Golinelli, Davide, Gona, Philimon N, Goudarzi, Houman, Goudarzian, Amir Hossein, Goyal, Anmol, Greenhalgh, Scott, Grivna, Michal, Guarducci, Giovanni, Gubari, Mohammed Ibrahim Mohialdeen, Gudeta, Mesay Dechasa, Guha, Avirup, Guicciardi, Stefano, Gunawardane, Damitha Asanga, Gunturu, Sasidhar, Guo, Cui, Gupta, Anish Kumar, Gupta, Bhawna, Gupta, Indarchand Ratanlal, Gupta, Rajat Das, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vijai Kumar, Gupta, Vivek Kumar, Gutiérrez, Reyna Alma, Habibzadeh, Farrokh, Habibzadeh, Parham, Hachinski, Vladimir, Haddadi, Mohammad, Haddadi, Rasool, Haep, Nils, Hajj Ali, Adel, Halboub, Esam S, Halim, Sobia Ahsan, Hall, Brian J, Haller, Sebastian, Halwani, Rabih, Hamadeh, Randah R, Hamagharib Abdullah, Kanaan, Hamidi, Samer, Hamiduzzaman, Mohammad, Hammoud, Ahmad, Hanifi, Nasrin, Hankey, Graeme J, Hannan, Md Abdul, Haque, Md Nuruzzaman, Harapan, Harapan, Haro, Josep Maria, Hasaballah, Ahmed I, Hasan, Faizul, Hasan, Ikramul, Hasan, M Tasdik, Hasani, Hamidreza, Hasanian, Mohammad, Hasanpour- Dehkordi, Ali, Hassan, Abbas M, Hassan, Amr, Hassanian-Moghaddam, Hossein, Hassanipour, Soheil, Haubold, Johannes, Havmoeller, Rasmus J, Hay, Simon I, Hbid, Youssef, Hebert, Jeffrey J, Hegazi, Omar E, Heidari, Golnaz, Heidari, Mohammad, Heidari-Foroozan, Mahsa, Heidari-Soureshjani, Reza, Helfer, Bartosz, Herteliu, Claudiu, Hesami, Hamed, Hettiarachchi, Dineshani, Heyi, Demisu Zenbaba, Hezam, Kamal, Hiraike, Yuta, Hoffman, Howard J, Holla, Ramesh, Horita, Nobuyuki, Hossain, Md Belal, Hossain, Md Mahbub, Hossain, Sahadat, Hosseini, Mohammad-Salar, Hosseinzadeh, Hassan, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Hsairi, Mohamed, Hsieh, Vivian Chia-rong, Hu, Chengxi, Huang, Junjie, Huda, Md Nazmul, Hugo, Fernando N, Hultström, Michael, Hussain, Javid, Hussain, Salman, Hussein, Nawfal R, Huy, Le Duc, Huynh, Hong-Han, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Idowu, Oluwatope Olaniyi, Ijo, Desta, Ikuta, Kevin S, Ilaghi, Mehran, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Immurana, Mustapha, Inbaraj, Leeberk Raja, Iradukunda, Arnaud, Iravanpour, Farideh, Iregbu, Kenneth Chukwuemeka, Islam, Md Rabiul, Islam, Mohammad Mainul, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Ismail, Nahlah Elkudssiah, Isola, Gaetano, Iwagami, Masao, Iwu, Chidozie C D, Iwu-Jaja, Chinwe Juliana, Iyer, Mahalaxmi, J, Linda Merin, Jaafari, Jalil, Jacob, Louis, Jacobsen, Kathryn H, Jadidi-Niaragh, Farhad, Jafarinia, Morteza, Jaggi, Khushleen, Jahankhani, Kasra, Jahanmehr, Nader, Jahrami, Haitham, Jain, Akhil, Jain, Nityanand, Jairoun, Ammar Abdulrahman, Jakovljevic, Mihajlo, Jalilzadeh Yengejeh, Reza, Jamshidi, Elham, Jani, Chinmay T, Janko, Mark M, Jatau, Abubakar Ibrahim, Jayapal, Sathish Kumar, Jayaram, Shubha, Jeganathan, Jayakumar, Jema, Alelign Tasew, Jemere, Digisie Mequanint, Jeong, Wonjeong, Jha, Anil K, Jha, Ravi Prakash, Ji, John S, Jiang, Heng, Jin, Yingzhao, Jin, Yinzi, Johnson, Olatunji, Jomehzadeh, Nabi, Jones, Darwin Phan, Joo, Tamas, Joseph, Abel, Joseph, Nitin, Joshua, Charity Ehimwenma, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kaambwa, Billingsley, Kabir, Ali, Kabir, Hannaneh, Kabir, Zubair, Kadashetti, Vidya, Kahe, Farima, Kakodkar, Pradnya Vishal, Kalani, Rizwan, Kalankesh, Leila R, Kaliyadan, Feroze, Kalra, Sanjay, Kamath, Ashwin, Kamireddy, Arun, Kanagasabai, Thanigaivelan, Kandel, Himal, Kanmiki, Edmund Wedam, Kanmodi, Kehinde Kazeem, Kantar, Rami S, Kapoor, Neeti, Karajizadeh, Mehrdad, Karami Matin, Behzad, Karanth, Shama D, Karaye, Ibraheem M, Karim, Asima, Karimi, Hanie, Karimi, Salah Eddin, Karimi Behnagh, Arman, Karkhah, Samad, Karna, Ajit K, Kashoo, Faizan Zaffar, Kasraei, Hengameh, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J, Kassel, Molly B, Katamreddy, Adarsh, Katikireddi, Srinivasa Vittal, Katoto, Patrick DMC, Kauppila, Joonas H, Kaur, Navjot, Kaydi, Neda, Kayibanda, Jeanne Françoise, Kayode, Gbenga A, Kazemi, Foad, Kazemian, Sina, Kazeminia, sara, Keikavoosi-Arani, Leila, Keller, Cathleen, Kempen, John H, Kerr, Jessica A, Kesse-Guyot, Emmanuelle, Keykhaei, Mohammad, Khadembashiri, Mohamad Mehdi, Khadembashiri, Mohammad Amin, Khafaie, Morteza Abdullatif, Khajuria, Himanshu, Khalafi, Mohammad, Khalaji, Amirmohammad, Khalid, Nauman, Khalil, Ibrahim A, Khamesipour, Faham, Khan, Asaduzzaman, Khan, Gulfaraz, Khan, Ikramullah, Khan, Imteyaz A, Khan, Maseer, Khan, Moien AB, Khan, Taimoor, Khan suheb, Mahammed Ziauddin, Khanmohammadi, Shaghayegh, Khatab, Khaled, Khatami, Fatemeh, Khavandegar, Armin, Khayat Kashani, Hamid Reza, Kheirallah, Khalid A, Khidri, Feriha Fatima, Khodadoust, Elaheh, Khormali, Moein, Khosrowjerdi, Mahmood, Khubchandani, Jagdish, Khusun, Helda, Kifle, Zemene Demelash, Kim, Grace, Kim, Jihee, Kimokoti, Ruth W, Kinzel, Kasey E, Kiross, Girmay Tsegay, Kisa, Adnan, Kisa, Sezer, Kiss, Juniper Boroka, Kivimäki, Mika, Klu, Desmond, Knudsen, Ann Kristin Skrindo, Kolahi, Ali-Asghar, Kompani, Farzad, Koren, Gerbrand, Kosen, Soewarta, Kostev, Karel, Kotnis, Ashwin Laxmikant, Koul, Parvaiz A, Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Kravchenko, Michael A, Krishan, Kewal, Krishna, Hare, Krishnamoorthy, Vijay, Krishnamoorthy, Yuvaraj, Krohn, Kris J, Kuate Defo, Barthelemy, Kubeisy, Connor M, Kucuk Bicer, Burcu, Kuddus, Md Abdul, Kuddus, Mohammed, Kuitunen, Ilari, Kujan, Omar, Kulimbet, Mukhtar, Kulkarni, Vishnutheertha, Kumar, Ashish, Kumar, Harish, Kumar, Nithin, Kumar, Rahul, Kumar, Shiv, Kumari, Madhulata, Kurmanova, Almagul, Kurmi, Om P, Kusnali, Asep, Kusuma, Dian, Kutluk, Tezer, Kuttikkattu, Ambily, Kyei, Evans F, Kyriopoulos, Ilias, La Vecchia, Carlo, Ladan, Muhammad Awwal, Laflamme, Lucie, Lahariya, Chandrakant, Lahmar, Abdelilah, Lai, Daphne Teck Ching, Laksono, Tri, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lám, Judit, Lamnisos, Demetris, Lan, Tuo, Lanfranchi, Francesco, Langguth, Berthold, Lansingh, Van Charles, Laplante-Lévesque, Ariane, Larijani, Bagher, Larsson, Anders O, Lasrado, Savita, Latief, Kamaluddin, Latif, Mahrukh, Latifinaibin, Kaveh, Lauriola, Paolo, Le, Long Khanh Dao, Le, Nhi Huu Hanh, Le, Thao Thi Thu, Le, Trang Diep Thanh, Lee, Munjae, Lee, Paul H, Lee, Sang-woong, Lee, Seung Won, Lee, Wei-Chen, Lee, Yo Han, Legesse, Samson Mideksa, Leigh, James, Lenzi, Jacopo, Leong, Elvynna, Lerango, Temesgen L, Li, Ming-Chieh, Li, Wei, Li, Xiaopan, Li, Yichong, Li, Zhihui, Libra, Massimo, Ligade, Virendra S, Likaka, Andrew Tiyamike Makhiringa, Lim, Lee-Ling, Lin, Ro-Ting, Lin, Shuzhi, Lioutas, Vasileios-Arsenios, Listl, Stefan, Liu, Jue, Liu, Simin, Liu, Xiaofeng, Livingstone, Katherine M, Llanaj, Erand, Lo, Chun-Han, Loreche, Arianna Maever, Lorenzovici, László, Lotfi, Mojgan, Lotfizadeh, Masoud, Lozano, Rafael, Lubinda, Jailos, Lucchetti, Giancarlo, 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- Abstract
Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period.
- Published
- 2024
- Full Text
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4. The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging
- Author
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Ungvari, Zoltan, Tabák, Adam G., Adany, Roza, Purebl, György, Kaposvári, Csilla, Fazekas-Pongor, Vince, Csípő, Tamás, Szarvas, Zsófia, Horváth, Krisztián, Mukli, Peter, Balog, Piroska, Bodizs, Robert, Ujma, Peter, Stauder, Adrienne, Belsky, Daniel W., Kovács, Illés, Yabluchanskiy, Andriy, Maier, Andrea B., Moizs, Mariann, Östlin, Piroska, Yon, Yongjie, Varga, Péter, Vokó, Zoltán, Papp, Magor, Takács, István, Vásárhelyi, Barna, Torzsa, Péter, Ferdinandy, Péter, Csiszar, Anna, Benyó, Zoltán, Szabó, Attila J., Dörnyei, Gabriella, Kivimäki, Mika, Kellermayer, Miklos, and Merkely, Bela
- Abstract
The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.
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- 2024
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5. Learning from fall-related interventions for older people at home: A scoping review.
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Palonen, Mira, Turja, Tuuli, Castano de la Rosa, Raúl, Ilomäki, Sakari, Kaasalainen, Tapio, Kivimäki Rantanen, Karoliina, Pelsmakers, Sofie, Ruusuvuori, Johanna, Valtonen, Annika, and Kaunonen, Marja
- Abstract
• The field of fall-related intervention studies is wide-ranging. • Considerable number of fall-related interventions with no-effect. • Fall risk reduction with multiple intervention components. This scoping review aims to provide a better understanding about the fall-related interventions, and the conditions which stand out as effective in decreasing fall risks of older people at home. A total of 28 peer-reviewed papers were included when they reported interventions with an incidence of falls or fall-risk as a primary outcome for older people, focusing on the home environment, from 8 databases. Qualitative examination was complemented by quantitative risk ratio analysis where it was feasible. The interventions regarding incidence of falls had a mean risk rate of 0.75; moreover, interventions using multiple strategies were found relatively successful. The interventions regarding fall risk had a mean hazard rate of 0.66. A considerable number of no-effect ratios were evident. Combining education, home assessment or improvement, and use of technology with implementation by health service experts appears to be the most promising intervention strategy to reduce falls. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Association Between Depression and Physical Conditions Requiring Hospitalization.
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Frank, Philipp, Batty, G. David, Pentti, Jaana, Jokela, Markus, Poole, Lydia, Ervasti, Jenni, Vahtera, Jussi, Lewis, Glyn, Steptoe, Andrew, and Kivimäki, Mika
- Subjects
MUSCULOSKELETAL system diseases ,MENTAL illness ,MYOCARDIAL ischemia ,CORONARY disease ,ENDOCRINE diseases - Abstract
This cohort study examines data from the UK Biobank and 2 Finnish cohorts to gauge the association between depression and an array of physical conditions requiring hospital treatment. Key Points: Question: What are the most common conditions requiring hospital treatment in people with depression? Findings: In this cohort study that included 240 433 individuals, depression was associated with an increased risk of 29 hospital-treated conditions. For 12 of these conditions, there was evidence for a bidirectional relationship with depression; the highest cumulative incidence was observed for diseases of the endocrine, musculoskeletal, and circulatory systems. Meaning: In this study, the main causes of excess hospitalizations in people with depression were endocrine, musculoskeletal, and vascular diseases. Importance: Depression is associated with an increased risk of physical illness, but the most common causes of hospitalization among people with depression are unclear. Objective: To examine the association of depression with an array of physical conditions requiring hospital treatment. Design, Setting, and Participants: In this outcomewide prospective multicohort study, primary analysis was based on data from the UK Biobank, a population-based study in the United Kingdom. Analyses were repeated in an independent data set of 2 cohorts in Finland, a population-based study and an occupational cohort. Data analysis was conducted between April and September 2022. Exposures: Self-reported depression, recurrent severe major depression, recurrent moderate major depression, and a single major depressive episode. Main Outcomes and Measures: A total of 77 common health conditions ascertained from linkage data to national hospital and mortality registries. Results: The analytical sample of UK Biobank participants consisted of 130 652 individuals (71 565 women [54.8%]; 59 087 men [45.2%]; mean [SD] age at baseline, 63.3 [7.8] years). The pooled data from the Finnish replication cohorts included 109 781 participants (82 921 women [78.6%]; 26 860 men [21.4%]; mean [SD] age, 42 [10.8] years). In the main analysis, severe/moderately severe depression was associated with the incidence of 29 nonoverlapping conditions requiring hospital treatment during a 5-year follow-up. Twenty-five of these associations remained after adjustment for confounders and multiple testing (adjusted hazard ratio [HR] range, 1.52-23.03) and were confirmed in the analysis of the Finnish cohorts. These included sleep disorders (HR, 5.97; 95% CI, 3.27-10.89), diabetes (HR, 5.15; 95% CI, 2.52-10.50), ischemic heart disease (HR, 1.76; 95% CI, 1.36-2.29), chronic obstructive bronchitis (HR, 4.11; 95% CI, 2.56-6.60), bacterial infections (HR, 2.52; 95% CI, 1.99-3.19), back pain (HR, 3.99; 95% CI, 2.96-5.38), and osteoarthritis (HR, 1.80; 95% CI, 1.46-2.20). The highest cumulative incidence was observed for endocrine and related internal organ diseases (245 per 1000 persons with depression; risk difference relative to unaffected individuals: 9.8%), musculoskeletal diseases (91 per 1000 persons; risk difference, 3.7%), and diseases of the circulatory system and blood (86 per 1000 persons; risk difference, 3.9%). The cumulative incidence was lower for hospital-treated mental, behavioral, and neurological disorders (20 in 1000 persons; risk difference, 1.7%). Depression was also associated with disease progression in people with prevalent heart disease or diabetes, and for 12 conditions, there was evidence of a bidirectional relationship. Conclusions and Relevance: In this study, the most common causes of hospitalization in people with depression were endocrine, musculoskeletal, and vascular diseases, not psychiatric disorders. These findings suggest that depression should be considered as a target for the prevention of physical and mental disease. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021
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Ong, Kanyin Liane, Stafford, Lauryn K, McLaughlin, Susan A, Boyko, Edward J, Vollset, Stein Emil, Smith, Amanda E, Dalton, Bronte E, Duprey, Joe, Cruz, Jessica A, Hagins, Hailey, Lindstedt, Paulina A, Aali, Amirali, Abate, Yohannes Habtegiorgis, Abate, Melsew Dagne, Abbasian, Mohammadreza, Abbasi-Kangevari, Zeinab, Abbasi-Kangevari, Mohsen, Abd ElHafeez, Samar, Abd-Rabu, Rami, Abdulah, Deldar Morad, Abdullah, Abu Yousuf Md, Abedi, Vida, Abidi, Hassan, Aboagye, Richard Gyan, Abolhassani, Hassan, Abu-Gharbieh, Eman, Abu-Zaid, Ahmed, Adane, Tigist Demssew, Adane, Denberu Eshetie, Addo, Isaac Yeboah, Adegboye, Oyelola A, Adekanmbi, Victor, Adepoju, Abiola Victor, Adnani, Qorinah Estiningtyas Sakilah, Afolabi, Rotimi Felix, Agarwal, Gina, Aghdam, Zahra Babaei, Agudelo-Botero, Marcela, Aguilera Arriagada, Constanza Elizabeth, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Danish, Ahmad, Rizwan, Ahmad, Sajjad, Ahmad, Aqeel, Ahmadi, Ali, Ahmadi, Keivan, Ahmed, Ayman, Ahmed, Ali, Ahmed, Luai A, Ahmed, Syed Anees, Ajami, Marjan, Akinyemi, Rufus Olusola, Al Hamad, Hanadi, Al Hasan, Syed Mahfuz, AL-Ahdal, Tareq Mohammed Ali, Alalwan, Tariq A, Al-Aly, Ziyad, AlBataineh, Mohammad T, Alcalde-Rabanal, Jacqueline Elizabeth, Alemi, Sharifullah, Ali, Hassam, Alinia, Tahereh, Aljunid, Syed Mohamed, Almustanyir, Sami, Al-Raddadi, Rajaa M, Alvis-Guzman, Nelson, Amare, Firehiwot, Ameyaw, Edward Kwabena, Amiri, Sohrab, Amusa, Ganiyu Adeniyi, Andrei, Catalina Liliana, Anjana, Ranjit Mohan, Ansar, Adnan, Ansari, Golnoosh, Ansari-Moghaddam, Alireza, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Aravkin, Aleksandr Y, Areda, Demelash, Arifin, Hidayat, Arkew, Mesay, Armocida, Benedetta, Ärnlöv, Johan, Artamonov, Anton A, Arulappan, Judie, Aruleba, Raphael Taiwo, Arumugam, Ashokan, Aryan, Zahra, Asemu, Mulu Tiruneh, Asghari-Jafarabadi, Mohammad, Askari, Elaheh, Asmelash, Daniel, Astell-Burt, Thomas, Athar, Mohammad, Athari, Seyyed Shamsadin, Atout, Maha Moh'd Wahbi, Avila-Burgos, Leticia, Awaisu, Ahmed, Azadnajafabad, Sina, B, Darshan B, Babamohamadi, Hassan, Badar, Muhammad, Badawi, Alaa, Badiye, Ashish D, Baghcheghi, Nayereh, Bagheri, Nasser, Bagherieh, Sara, Bah, Sulaiman, Bahadory, Saeed, Bai, Ruhai, Baig, Atif Amin, Baltatu, Ovidiu Constantin, Baradaran, Hamid Reza, Barchitta, Martina, Bardhan, Mainak, Barengo, Noel C, Bärnighausen, Till Winfried, Barone, Mark Thomaz Ugliara, Barone-Adesi, Francesco, Barrow, Amadou, Bashiri, Hamideh, Basiru, Afisu, Basu, Sanjay, Basu, Saurav, Batiha, Abdul-Monim Mohammad, Batra, Kavita, Bayih, Mulat Tirfie, Bayileyegn, Nebiyou Simegnew, Behnoush, Amir Hossein, Bekele, Alehegn Bekele, Belete, Melaku Ashagrie, Belgaumi, Uzma Iqbal, Belo, Luis, Bennett, Derrick A, Bensenor, Isabela M, Berhe, Kidanemaryam, Berhie, Alemshet Yirga, Bhaskar, Sonu, Bhat, Ajay Nagesh, Bhatti, Jasvinder Singh, Bikbov, Boris, Bilal, Faiq, Bintoro, Bagas Suryo, Bitaraf, Saeid, Bitra, Veera R, Bjegovic-Mikanovic, Vesna, Bodolica, Virginia, Boloor, Archith, Brauer, Michael, Brazo-Sayavera, Javier, Brenner, Hermann, Butt, Zahid A, Calina, Daniela, Campos, Luciana Aparecida, Campos-Nonato, Ismael R, Cao, Yin, Cao, Chao, Car, Josip, Carvalho, Márcia, Castañeda-Orjuela, Carlos A, Catalá-López, Ferrán, Cerin, Ester, Chadwick, Joshua, Chandrasekar, Eeshwar K, Chanie, Gashaw Sisay, Charan, Jaykaran, Chattu, Vijay Kumar, Chauhan, Kirti, Cheema, Huzaifa Ahmad, Chekol Abebe, Endeshaw, Chen, Simiao, Cherbuin, Nicolas, Chichagi, Fatemeh, Chidambaram, Saravana Babu, Cho, William C S, Choudhari, Sonali Gajanan, Chowdhury, Rajiv, Chowdhury, Enayet Karim, Chu, Dinh-Toi, Chukwu, Isaac Sunday, Chung, Sheng-Chia, Coberly, Kaleb, Columbus, Alyssa, Contreras, Daniela, Cousin, Ewerton, Criqui, Michael H, Cruz-Martins, Natália, Cuschieri, Sarah, Dabo, Bashir, Dadras, Omid, Dai, Xiaochen, Damasceno, Albertino Antonio Moura, Dandona, Rakhi, Dandona, Lalit, Das, Saswati, Dascalu, Ana Maria, Dash, Nihar Ranjan, Dashti, Mohsen, Dávila-Cervantes, Claudio Alberto, De la Cruz-Góngora, Vanessa, Debele, Gebiso Roba, Delpasand, Kourosh, Demisse, Fitsum Wolde, Demissie, Getu Debalkie, Deng, Xinlei, Denova-Gutiérrez, Edgar, Deo, Salil V, Dervišević, Emina, Desai, Hardik Dineshbhai, Desale, Aragaw Tesfaw, Dessie, Anteneh Mengist, Desta, Fikreab, Dewan, Syed Masudur Rahman, Dey, Sourav, Dhama, Kuldeep, Dhimal, Meghnath, Diao, Nancy, Diaz, Daniel, Dinu, Monica, Diress, Mengistie, Djalalinia, Shirin, Doan, Linh Phuong, Dongarwar, Deepa, dos Santos Figueiredo, Francisco Winter, Duncan, Bruce B, Dutta, Siddhartha, Dziedzic, Arkadiusz Marian, Edinur, Hisham Atan, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, Elgendy, Islam Y, Elhadi, Muhammed, El-Huneidi, Waseem, Elmeligy, Omar Abdelsadek Abdou, Elmonem, Mohamed A, Endeshaw, Destaw, Esayas, Hawi Leul, Eshetu, Habitu Birhan, Etaee, Farshid, Fadhil, Ibtihal, Fagbamigbe, Adeniyi Francis, Fahim, Ayesha, Falahi, Shahab, Faris, MoezAlIslam Ezzat Mahmoud, Farrokhpour, Hossein, Farzadfar, Farshad, Fatehizadeh, Ali, Fazli, Ghazal, Feng, Xiaoqi, Ferede, Tomas Y, Fischer, Florian, Flood, David, Forouhari, Ali, Foroumadi, Roham, Foroutan Koudehi, Masoumeh, Gaidhane, Abhay Motiramji, Gaihre, Santosh, Gaipov, Abduzhappar, Galali, Yaseen, Ganesan, Balasankar, Garcia-Gordillo, MA, Gautam, Rupesh K, Gebrehiwot, Mesfin, Gebrekidan, Kahsu Gebrekirstos, Gebremeskel, Teferi Gebru, Getacher, Lemma, Ghadirian, Fataneh, Ghamari, Seyyed-Hadi, Ghasemi Nour, Mohammad, Ghassemi, Fariba, Golechha, Mahaveer, Goleij, Pouya, Golinelli, Davide, Gopalani, Sameer Vali, Guadie, Habtamu Alganeh, Guan, Shi-Yang, Gudayu, Temesgen Worku, Guimarães, Rafael Alves, Guled, Rashid Abdi, Gupta, Rajeev, Gupta, Kartik, Gupta, Veer Bala, Gupta, Vivek Kumar, Gyawali, Bishal, Haddadi, Rasool, Hadi, Najah R, Haile, Teklehaimanot Gereziher, Hajibeygi, Ramtin, Haj-Mirzaian, Arvin, Halwani, Rabih, Hamidi, Samer, Hankey, Graeme J, Hannan, Md Abdul, Haque, Shafiul, Harandi, Hamid, Harlianto, Netanja I, Hasan, S M Mahmudul, Hasan, Syed Shahzad, Hasani, Hamidreza, Hassanipour, Soheil, Hassen, Mohammed Bheser, Haubold, Johannes, Hayat, Khezar, Heidari, Golnaz, Heidari, Mohammad, Hessami, Kamran, Hiraike, Yuta, Holla, Ramesh, Hossain, Sahadat, Hossain, Md Shakhaoat, Hosseini, Mohammad-Salar, Hosseinzadeh, Mehdi, Hosseinzadeh, Hassan, Huang, Junjie, Huda, Md Nazmul, Hussain, Salman, Huynh, Hong-Han, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ikeda, Nayu, Ilic, Irena M, Ilic, Milena D, Inbaraj, Leeberk Raja, Iqbal, Afrin, Islam, Sheikh Mohammed Shariful, Islam, Rakibul M, Ismail, Nahlah Elkudssiah, Iso, Hiroyasu, Isola, Gaetano, Itumalla, Ramaiah, Iwagami, Masao, Iwu, Chidozie C D, Iyamu, Ihoghosa Osamuyi, Iyasu, Assefa N, Jacob, Louis, Jafarzadeh, Abdollah, Jahrami, Haitham, Jain, Rajesh, Jaja, Chinwe, Jamalpoor, Zahra, Jamshidi, Elham, Janakiraman, Balamurugan, Jayanna, Krishnamurthy, Jayapal, Sathish Kumar, Jayaram, Shubha, Jayawardena, Ranil, Jebai, Rime, Jeong, Wonjeong, Jin, Yinzi, Jokar, Mohammad, Jonas, Jost B, Joseph, Nitin, Joseph, Abel, Joshua, Charity Ehimwenma, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Kaambwa, Billingsley, Kabir, Ali, Kabthymer, Robel Hussen, Kadashetti, Vidya, Kahe, Farima, Kalhor, Rohollah, Kandel, Himal, Karanth, Shama D, Karaye, Ibraheem M, Karkhah, Samad, Katoto, Patrick DMC, Kaur, Navjot, Kazemian, Sina, Kebede, Sewnet Adem, Khader, Yousef Saleh, Khajuria, Himanshu, Khalaji, Amirmohammad, Khan, Moien AB, Khan, Maseer, Khan, Ajmal, Khanal, Saval, Khatatbeh, Moawiah Mohammad, Khater, Amir M, Khateri, Sorour, khorashadizadeh, Fatemeh, Khubchandani, Jagdish, Kibret, Biruk Getahun, Kim, Min Seo, Kimokoti, Ruth W, Kisa, Adnan, Kivimäki, Mika, Kolahi, Ali-Asghar, Komaki, Somayeh, Kompani, Farzad, Koohestani, Hamid Reza, Korzh, Oleksii, Kostev, Karel, Kothari, Nikhil, Koyanagi, Ai, Krishan, Kewal, Krishnamoorthy, Yuvaraj, Kuate Defo, Barthelemy, Kuddus, Mohammed, Kuddus, Md Abdul, Kumar, Rakesh, Kumar, Harish, Kundu, Satyajit, Kurniasari, Maria Dyah, Kuttikkattu, Ambily, La Vecchia, Carlo, Lallukka, Tea, Larijani, Bagher, Larsson, Anders O, Latief, Kamaluddin, Lawal, Basira Kankia, Le, Thao Thi Thu, Le, Trang Thi Bich, Lee, Shaun Wen Huey, Lee, Munjae, Lee, Wei-Chen, Lee, Paul H, Lee, Sang-woong, Lee, Seung Won, Legesse, Samson Mideksa, Lenzi, Jacopo, Li, Yongze, Li, Ming-Chieh, Lim, Stephen S, Lim, Lee-Ling, Liu, Xuefeng, Liu, Chaojie, Lo, Chun-Han, Lopes, Graciliana, Lorkowski, Stefan, Lozano, Rafael, Lucchetti, Giancarlo, Maghazachi, Azzam A, Mahasha, Phetole Walter, Mahjoub, Soleiman, Mahmoud, Mansour Adam, Mahmoudi, Razzagh, Mahmoudimanesh, Marzieh, Mai, Anh Tuan, Majeed, Azeem, Majma Sanaye, Pantea, Makris, Konstantinos Christos, Malhotra, Kashish, Malik, Ahmad Azam, Malik, Iram, Mallhi, Tauqeer Hussain, Malta, Deborah Carvalho, Mamun, Abdullah A, Mansouri, Borhan, Marateb, Hamid Reza, Mardi, Parham, Martini, Santi, Martorell, Miquel, Marzo, Roy Rillera, Masoudi, Reza, Masoudi, Sahar, Mathews, Elezebeth, Maugeri, Andrea, Mazzaglia, Giampiero, Mekonnen, Teferi, Meshkat, Mahboobeh, Mestrovic, Tomislav, Miao Jonasson, Junmei, Miazgowski, Tomasz, Michalek, Irmina Maria, Minh, Le Huu Nhat, Mini, GK, Miranda, J Jaime, Mirfakhraie, Reza, Mirrakhimov, Erkin M, Mirza-Aghazadeh-Attari, Mohammad, Misganaw, Awoke, Misgina, Kebede Haile, Mishra, Manish, Moazen, Babak, Mohamed, Nouh Saad, Mohammadi, Esmaeil, Mohammadi, Mohsen, Mohammadian-Hafshejani, Abdollah, Mohammadshahi, Marita, Mohseni, Alireza, Mojiri-forushani, Hoda, Mokdad, Ali H, Momtazmanesh, Sara, Monasta, Lorenzo, Moniruzzaman, Md, Mons, Ute, Montazeri, Fateme, Moodi Ghalibaf, AmirAli, Moradi, Yousef, Moradi, Maryam, Moradi Sarabi, Mostafa, Morovatdar, Negar, Morrison, Shane Douglas, Morze, Jakub, Mossialos, Elias, Mostafavi, Ebrahim, Mueller, Ulrich Otto, Mulita, Francesk, Mulita, Admir, Murillo-Zamora, Efrén, Musa, Kamarul Imran, Mwita, Julius C, Nagaraju, Shankar Prasad, Naghavi, Mohsen, Nainu, Firzan, Nair, Tapas Sadasivan, Najmuldeen, Hastyar Hama Rashid, Nangia, Vinay, Nargus, Shumaila, Naser, Abdallah Y, Nassereldine, Hasan, Natto, Zuhair S, Nauman, Javaid, Nayak, Biswa Prakash, Ndejjo, Rawlance, Negash, Hadush, Negoi, Ruxandra Irina, Nguyen, Hau Thi Hien, Nguyen, Dang H, Nguyen, Phat Tuan, Nguyen, Van Thanh, Nguyen, Hien Quang, Niazi, Robina Khan, Nigatu, Yeshambel T, Ningrum, Dina Nur Anggraini, Nizam, Muhammad A, Nnyanzi, Lawrence Achilles, Noreen, Mamoona, Noubiap, Jean Jacques, Nzoputam, Ogochukwu Janet, Nzoputam, Chimezie Igwegbe, Oancea, Bogdan, Odogwu, Nkechi Martina, Odukoya, Oluwakemi Ololade, Ojha, Vivek Anand, Okati-Aliabad, Hassan, Okekunle, Akinkunmi Paul, Okonji, Osaretin Christabel, Okwute, Patrick Godwin, Olufadewa, Isaac Iyinoluwa, Onwujekwe, Obinna E, Ordak, Michal, Ortiz, Alberto, Osuagwu, Uchechukwu Levi, Oulhaj, Abderrahim, Owolabi, Mayowa O, Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Palladino, Raffaele, Panagiotakos, Demosthenes, Panda-Jonas, Songhomitra, Pandey, Ashok, Pandey, Anamika, Pandi-Perumal, Seithikurippu R, Pantea Stoian, Anca Mihaela, Pardhan, Shahina, Parekh, Tarang, Parekh, Utsav, Pasovic, Maja, Patel, Jay, Patel, Jenil R, Paudel, Uttam, Pepito, Veincent Christian Filipino, Pereira, Marcos, Perico, Norberto, Perna, Simone, Petcu, Ionela-Roxana, Petermann-Rocha, Fanny Emily, Podder, Vivek, Postma, Maarten J, Pourali, Ghazaleh, Pourtaheri, Naeimeh, Prates, Elton Junio Sady, Qadir, Mirza Muhammad Fahd, Qattea, Ibrahim, Raee, Pourya, Rafique, Ibrar, Rahimi, Mehran, Rahimifard, Mahban, Rahimi-Movaghar, Vafa, Rahman, Md Obaidur, Rahman, Muhammad Aziz, Rahman, Mohammad Hifz Ur, Rahman, Mosiur, Rahman, Md Mosfequr, Rahmani, Mohamed, Rahmani, Shayan, Rahmanian, Vahid, Rahmawaty, Setyaningrum, Rahnavard, Niloufar, Rajbhandari, Bibek, Ram, Pradhum, Ramazanu, Sheena, Rana, Juwel, Rancic, Nemanja, Ranjha, Muhammad Modassar Ali Nawaz, Rao, Chythra R, Rapaka, Deepthi, Rasali, Drona Prakash, Rashedi, Sina, Rashedi, Vahid, Rashid, Ahmed Mustafa, Rashidi, Mohammad-Mahdi, Ratan, Zubair Ahmed, Rawaf, Salman, Rawal, Lal, Redwan, Elrashdy Moustafa Mohamed, Remuzzi, Giuseppe, Rengasamy, Kannan RR, Renzaho, Andre M N, Reyes, Luis Felipe, Rezaei, Nima, Rezaei, Nazila, Rezaeian, Mohsen, Rezazadeh, Hossein, Riahi, Seyed Mohammad, Rias, Yohanes Andy, Riaz, Muhammad, Ribeiro, Daniela, Rodrigues, Mónica, Rodriguez, Jefferson Antonio Buendia, Roever, Leonardo, Rohloff, Peter, Roshandel, Gholamreza, Roustazadeh, Abazar, Rwegerera, Godfrey M, Saad, Aly M A, Saber-Ayad, Maha Mohamed, Sabour, Siamak, Sabzmakan, Leila, Saddik, Basema, Sadeghi, Erfan, Saeed, Umar, Saeedi Moghaddam, Sahar, Safi, Sare, Safi, Sher Zaman, Saghazadeh, Amene, Saheb Sharif-Askari, Narjes, Saheb Sharif-Askari, Fatemeh, Sahebkar, Amirhossein, Sahoo, Soumya Swaroop, Sahoo, Harihar, Saif-Ur-Rahman, KM, Sajid, Mirza Rizwan, Salahi, Sarvenaz, Salahi, Saina, Saleh, Mohamed A, Salehi, Mohammad Amin, Salomon, Joshua A, Sanabria, Juan, Sanjeev, Rama Krishna, Sanmarchi, Francesco, Santric-Milicevic, Milena M, Sarasmita, Made Ary, Sargazi, Saman, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sawhney, Monika, Schlaich, Markus P, Schmidt, Maria Inês, Schuermans, Art, Seidu, Abdul-Aziz, Senthil Kumar, Nachimuthu, Sepanlou, Sadaf G, Sethi, Yashendra, Seylani, Allen, Shabany, Maryam, Shafaghat, Tahereh, Shafeghat, Melika, Shafie, Mahan, Shah, Nilay S, Shahid, Samiah, Shaikh, Masood Ali, Shanawaz, Mohd, Shannawaz, Mohammed, Sharfaei, Sadaf, Shashamo, Bereket Beyene, Shiri, Rahman, Shittu, Aminu, Shivakumar, K M, Shivalli, Siddharudha, Shobeiri, Parnian, Shokri, Fereshteh, Shuval, Kerem, Sibhat, Migbar Mekonnen, Silva, Luís Manuel Lopes Rodrigues, Simpson, Colin R, Singh, Jasvinder A, Singh, Paramdeep, Singh, Surjit, Siraj, Md Shahjahan, Skryabina, Anna Aleksandrovna, Sohag, Abdullah Al Mamun, Soleimani, Hamidreza, Solikhah, Solikhah, Soltani-Zangbar, Mohammad Sadegh, Somayaji, Ranjani, Sorensen, Reed J D, Starodubova, Antonina V, Sujata, Sujata, Suleman, Muhammad, Sun, Jing, Sundström, Johan, Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabatabaeizadeh, Seyed-Amir, Tabish, Mohammad, Taheri, Majid, Taheri, Ensiyeh, Taki, Elahe, Tamuzi, Jacques JL Lukenze, Tan, Ker-Kan, Tat, Nathan Y, Taye, Birhan Tsegaw, Temesgen, Worku Animaw, Temsah, Mohamad-Hani, Tesler, Riki, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Thapa, Rajshree, Tharwat, Samar, Thomas, Nihal, Ticoalu, Jansje Henny Vera, Tiyuri, Amir, Tonelli, Marcello, Tovani-Palone, Marcos Roberto, Trico, Domenico, Trihandini, Indang, Tripathy, Jaya Prasad, Tromans, Samuel Joseph, Tsegay, Guesh Mebrahtom, Tualeka, Abdul Rohim, Tufa, Derara Girma, Tyrovolas, Stefanos, Ullah, Sana, Upadhyay, Era, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Valizadeh, Rohollah, van Daalen, Kim Robin, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vaziri, Siavash, Verma, Madhur verma, Verras, Georgios-Ioannis, Vo, Danh Cao, Wagaye, Birhanu, Waheed, Yasir, Wang, Ziyue, Wang, Yanqing, Wang, Cong, Wang, Fang, Wassie, Gizachew Tadesse, Wei, Melissa Y Wei, Weldemariam, Abrha Hailay, Westerman, Ronny, Wickramasinghe, Nuwan Darshana, Wu, YiFan, Wulandari, Ratna DWI, Xia, Juan, Xiao, Hong, Xu, Suowen, Xu, Xiaoyue, Yada, Dereje Y, Yang, Lin, Yatsuya, Hiroshi, Yesiltepe, Metin, Yi, Siyan, Yohannis, Hunachew Kibret, Yonemoto, Naohiro, You, Yuyi, Zaman, Sojib Bin, Zamora, Nelson, Zare, Iman, Zarea, Kourosh, Zarrintan, Armin, Zastrozhin, Mikhail Sergeevich, Zeru, Naod Gebrekrstos, Zhang, Zhi-Jiang, Zhong, Chenwen, Zhou, Jingjing, Zielińska, Magdalena, Zikarg, Yossef Teshome, Zodpey, Sanjay, Zoladl, Mohammad, Zou, Zhiyong, Zumla, Alimuddin, Zuniga, Yves Miel H, Magliano, Dianna J, Murray, Christopher J L, Hay, Simon I, and Vos, Theo
- Abstract
Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050.
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- 2023
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8. Forming Bonds While Breaking Old Ones: Isomer-Dependent Formation of H3O+ from Aminobenzoic Acid During X‑ray-Induced Fragmentation.
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Abid, Abdul Rahman, Veteläinen, Onni, Boudjemia, Nacer, Pelimanni, Eetu, Kivimäki, Antti, Alatalo, Matti, Huttula, Marko, Björneholm, Olle, and Patanen, Minna
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- 2023
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9. Histories of Emotions and Experiences. Studying Soldiers' Letters, Poems, and Memoirs.
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Pahl, Kerstin Maria and Kivimäki, Ville
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The article focuses on merging the history of emotions with the history of experience, exploring the nuanced relationship between the two in historical research. It mentions analyzing war writing from different eras, the authors argue for a closer examination of genres where emotions and experiences intersect, highlighting the significance of understanding how norms for feeling and expressing intersect with one another.
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- 2023
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10. Association of sleep with cognitive function during retirement transition: the Whitehall II study.
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Teräs, Tea, Rovio, Suvi, Pentti, Jaana, Head, Jenny, Kivimäki, Mika, and Stenholm, Sari
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- 2023
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11. Severe Infection and Risk of Cardiovascular Disease: A Multicohort Study
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Sipilä, Pyry N., Lindbohm, Joni V., Batty, G. David, Heikkilä, Nelli, Vahtera, Jussi, Suominen, Sakari, Väänänen, Ari, Koskinen, Aki, Nyberg, Solja T., Meri, Seppo, Pentti, Jaana, Warren-Gash, Charlotte, Hayward, Andrew C., and Kivimäki, Mika
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- 2023
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12. Nurse Staffing Level, Length of Work Experience, and Risk of Health Care–Associated Infections Among Hospital Patients
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Peutere, Laura, Terho, Kirsi, Pentti, Jaana, Ropponen, Annina, Kivimäki, Mika, Härmä, Mikko, Krutova, Oxana, Ervasti, Jenni, Koskinen, Aki, and Virtanen, Marianna
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- 2023
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13. Forming Bonds While Breaking Old Ones: Isomer-Dependent Formation of H3O+from Aminobenzoic Acid During X-ray-Induced Fragmentation
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Abid, Abdul Rahman, Veteläinen, Onni, Boudjemia, Nacer, Pelimanni, Eetu, Kivimäki, Antti, Alatalo, Matti, Huttula, Marko, Björneholm, Olle, and Patanen, Minna
- Abstract
Intramolecular hydrogen transfer, a reaction where donor and acceptor sites of a hydrogen atom are part of the same molecule, is a ubiquitous reaction in biochemistry and organic synthesis. In this work, we report hydronium ion (H3O+) production from aminobenzoic acid (ABA) after core-level ionization with soft X-ray synchrotron radiation. The formation of H3O+during the fragmentation requires that at least two hydrogen atoms migrate to one of the oxygen atoms within the molecule. The comparison of two structural isomers, ortho- and meta-ABA, revealed that the production of H3O+depends strongly on the structure of the molecule, the ortho-isomer being much more prone to produce H3O+. The isomer-dependency suggests that the amine group acts as a donor in the hydrogen transfer process. In the case of ortho-ABA, detailed H3O+production pathways were investigated using photoelectron-photoion-photoion coincidence (PEPIPICO) spectroscopy. It was found that H3O+can result from a direct two-body dissociation but also from sequential fragmentation processes.
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- 2023
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14. The multiple roles of life stress in metabolic disorders
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Kivimäki, Mika, Bartolomucci, Alessandro, and Kawachi, Ichiro
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The activation of stress-related neuroendocrine systems helps to maintain homeostasis, but excessive stress can damage body functions. We review current evidence from basic sciences and epidemiology linking stress to the development and progression of metabolic disorders throughout life. Findings from rodents demonstrate that stress can affect features of metabolic dysfunction, such as insulin resistance, glucose and lipid homeostasis, as well as ageing processes such as cellular senescence and telomere length shortening. In human studies, stressors in the home, workplace and neighbourhood are associated with accelerated ageing and metabolic and immune alterations, both directly and indirectly via behavioural risks. The likelihood of developing clinical conditions, such as diabetes mellitus and hepatic steatosis is increased in individuals with adverse childhood experiences or long-term (years) or severe stress at work or in private life. The increased risk of metabolic disorders is often associated with other stress-related conditions, such as mental health disorders, cardiovascular disease and increased susceptibility to infections. Equally, stress can worsen prognosis in metabolic diseases. As favourable modifications in stressors are associated with reductions in incidence of metabolic disorders, further investigation of the therapeutic value of targeting stress in personalized medicine is warranted.
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- 2023
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15. Risk of Macrovascular and Microvascular Disease in Diabetes Diagnosed Using Oral Glucose Tolerance Test With and Without Confirmation by Hemoglobin A1c: The Whitehall II Cohort Study
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Tabák, Adam G., Brunner, Eric J., Lindbohm, Joni V., Singh-Manoux, Archana, Shipley, Martin J., Sattar, Naveed, and Kivimäki, Mika
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- 2022
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16. Association of plasma gelsolin with frailty phenotype and mortality among octogenarian community-dwelling men: a cohort study.
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Strandberg, Timo E., Levinson, Susan L., DiNubile, Mark J., Jyväkorpi, Satu, and Kivimäki, Mika
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Background: Biomarkers are needed for frailty, a common phenotype often associated with muscle loss in older people. Plasma gelsolin (pGSN) is a protein largely synthesized and secreted by skeletal muscle. Aims: To investigate whether pGSN could be a biomarker of the frailty phenotype and predict mortality. Methods: A homogenous cohort of males (born 1919–1934, baseline n = 3490) has been followed since the 1960s. In 2010/11, frailty phenotypes by modified Fried criteria were assessed. pGSN was measured in a convenience subset (n = 469, mean age 83) and re-measured in survivors (n = 127) in 2017. Mortality through December 31, 2018 was retrieved from national registers. Regression models were used for analyses. Results: Of 469 males, 152 (32.4%) were robust, 284 (60.6%) prefrail, and 33 (7.0%) frail in 2010/11. There was a graded (p = 0.018) association between pGSN (mean 58.1 ug/mL, SD 9.3) and frailty. After multivariable adjustment, higher pGSN levels were associated with lower odds of having contemporaneous phenotypic prefrailty (OR per 1 SD 0.73, 95% CI 0.58–0.92) and frailty (OR per 1 SD 0.70, 95% CI 0.44–1.11). By 2018, 179 males (38.2%) had died, and higher baseline pGSN predicted a lower 7-year mortality rate (HR per 1 SD 0.85, 95% CI 0.72–1.00). pGSN concentrations in 2010/11 and 2017 were correlated (n = 127, r = 0.34, p < 0.001). Discussion: Higher baseline pGSN concentrations were associated with a persistently robust phenotype and lower mortality rate over 7 years in a cohort of octogenarian males with high socioeconomic status and may be a promising laboratory biomarker for the development of a frailty phenotype. [ABSTRACT FROM AUTHOR]
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- 2022
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17. Plasma proteins, cognitive decline, and 20‐year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies.
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Lindbohm, Joni V., Mars, Nina, Walker, Keenan A., Singh‐Manoux, Archana, Livingston, Gill, Brunner, Eric J., Sipilä, Pyry N., Saksela, Kalle, Ferrie, Jane E., Lovering, Ruth C., Williams, Stephen A., Hingorani, Aroon D., Gottesman, Rebecca F., Zetterberg, Henrik, and Kivimäki, Mika
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Introduction: Plasma proteins affect biological processes and are common drug targets but their role in the development of Alzheimer's disease and related dementias remains unclear. We examined associations between 4953 plasma proteins and cognitive decline and risk of dementia in two cohort studies with 20‐year follow‐ups. Methods: In the Whitehall II prospective cohort study proteins were measured using SOMAscan technology. Cognitive performance was tested five times over 20 years. Linkage to electronic health records identified incident dementia. The results were replicated in the Atherosclerosis Risk in Communities (ARIC) study. Results: Fifteen non‐amyloid/non‐tau–related proteins were associated with cognitive decline and dementia, were consistently identified in both cohorts, and were not explained by known dementia risk factors. Levels of six of the proteins are modifiable by currently approved medications for other conditions. Discussion: This study identified several plasma proteins in dementia‐free people that are associated with long‐term risk of cognitive decline and dementia. [ABSTRACT FROM AUTHOR]
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- 2022
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18. Aortic Pulse Wave Velocity as Adjunct Risk Marker for Assessing Cardiovascular Disease Risk: Prospective Study.
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Valencia-Hernandez, Carlos A., Lindbohm, Joni V., Shipley, Martin J., Wilkinson, Ian B., McEniery, Carmel M., Ahmadi-Abhari, Sara, Singh-Manoux, Archana, Kivimaki, Mika, Brunner, Eric J., Valencia-Hernández, Carlos A, and Kivimäki, Mika
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Background: Aortic pulse wave velocity is a noninvasive measure of aortic stiffness and arterial aging. Its current value in cardiovascular risk estimation practice is unknown. We aimed to establish whether aortic pulse wave velocity identified individuals with higher risk of incident major adverse cardiovascular events and improved performance of the American Heart Association/American College of Cardiology atherosclerotic cardiovascular disease risk score.Methods: This prospective analysis included 3837 Whitehall II cohort participants screened in 2008 to 2009, and followed for 11.7 years (mean=10.3, SD=1.81), without history of stroke, myocardial infarction, or coronary heart disease.Results: Mean age of the sample was 65.0 years (SD=5.6), 2831 participants (73.8%) were male and mean atherosclerotic cardiovascular disease risk score was 13.8%. At the end of follow-up, 411 individuals (10.7%) had suffered a major cardiovascular event. Those in the highest aortic pulse wave velocity quartile were at high risk (hazard ratio, 2.99 [95% CI, 2.25-3.97]) and reached the threshold for statin medication (7.5% risk) after 5 years whereas others reached it after 10 years (difference P<0.001). The addition of aortic pulse wave velocity to the risk score improved the C statistic (0.68 versus 0.67, P=0.03) and net reclassification index (4.6%, P=0.04 and 11.3%, P=0.02).Conclusions: Our results show that aortic stiffness predicted major adverse cardiovascular events in a cohort of elderly individuals, improving the performance of a widely used cardiovascular disease risk estimator. Aortic pulse wave velocity measurement is scalable, radiation-free, and easy to perform. Further studies on its applicability in cardiovascular disease risk assessment in primary care settings are needed. [ABSTRACT FROM AUTHOR]- Published
- 2022
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19. Neighborhood Socioeconomic Disadvantage and Childhood Body Mass Index Trajectories From Birth to 7 Years of Age.
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Rautava, Samuli, Turta, Olli, Vahtera, Jussi, Pentti, Jaana, Kivimäki, Mika, Pearce, Jamie, Kawachi, Ichiro, Rautava, Päivi, and Lagström, Hanna
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OBESITY ,RESEARCH ,CHILDHOOD obesity ,EVALUATION research ,SOCIOECONOMIC factors ,COMPARATIVE studies ,BODY mass index ,RESIDENTIAL patterns ,EDUCATIONAL attainment - Abstract
Background: The epidemic of increasing childhood overweight and obesity is a major global health concern, with local contextual factors identified as possible contributors. Robust research is needed to establish an evidence base supporting health policy decisions to reverse the trend. We aimed to examine the association between neighborhood socioeconomic disadvantage and trajectories of body mass index (BMI) from birth to age 7.Methods: The present study included 11,023 children born within the Southwest Finland Birth Cohort who were free of severe conditions affecting growth with adequate exposure and growth data. We obtained child growth data until school age from municipal follow-up clinics. We based cumulative childhood neighborhood socioeconomic disadvantage on the average annual income, unemployment, and level of education in a residential area defined using a geographic grid at a spatial resolution of 250 m by 250 m.Results: Cumulative neighborhood socioeconomic disadvantage was associated with distinct childhood BMI z score trajectories from birth to age 7. Despite being born in the lowest BMI z scores, children growing up in disadvantaged neighborhoods subsequently exhibited a trajectory of increasing BMI z scores starting at 4 years of age, ending up with a higher risk of overweight at the end of the follow-up (30%) as compared with children living in more affluent neighborhoods (22%). The corresponding risk of obesity was 5 % for those in affluent neighborhoods and 9 % and those in disadvantaged neighborhoods.Conclusion: Cumulative exposure to neighborhood socioeconomic disadvantage is independently associated with unfavorable BMI development and obesity in childhood. [ABSTRACT FROM AUTHOR]- Published
- 2022
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20. Work as a health risk
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Kivimäki, Mika and Batty, G David
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- 2024
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21. Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020
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Bryazka, Dana, Reitsma, Marissa B, Griswold, Max G, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abdoli, Amir, Abdollahi, Mohammad, Abdullah, Abu Yousuf Md, Abhilash, E S, Abu-Gharbieh, Eman, Acuna, Juan Manuel, Addolorato, Giovanni, Adebayo, Oladimeji M, Adekanmbi, Victor, Adhikari, Kishor, Adhikari, Sangeet, Adnani, Qorinah Estiningtyas Sakilah, Afzal, Saira, Agegnehu, Wubetu Yimam, Aggarwal, Manik, Ahinkorah, Bright Opoku, Ahmad, Araz Ramazan, Ahmad, Sajjad, Ahmad, Tauseef, Ahmadi, Ali, Ahmadi, Sepideh, Ahmed, Haroon, Ahmed Rashid, Tarik, Akunna, Chisom Joyqueenet, Al Hamad, Hanadi, Alam, Md Zakiul, Alem, Dejene Tsegaye, Alene, Kefyalew Addis, Alimohamadi, Yousef, Alizadeh, Atiyeh, Allel, Kasim, Alonso, Jordi, Alvand, Saba, Alvis-Guzman, Nelson, Amare, Firehiwot, Ameyaw, Edward Kwabena, Amiri, Sohrab, Ancuceanu, Robert, Anderson, Jason A, Andrei, Catalina Liliana, Andrei, Tudorel, Arabloo, Jalal, Arshad, Muhammad, Artamonov, Anton A, Aryan, Zahra, Asaad, Malke, Asemahagn, Mulusew A, Astell-Burt, Thomas, Athari, Seyyed Shamsadin, Atnafu, Desta Debalkie, Atorkey, Prince, Atreya, Alok, Ausloos, Floriane, Ausloos, Marcel, Ayano, Getinet, Ayanore, Martin Amogre ayanore, Ayinde, Olatunde O, Ayuso-Mateos, Jose L, Azadnajafabad, Sina, Azanaw, Melkalem Mamuye, Azangou-Khyavy, Mohammadreza, Azari Jafari, Amirhossein, Azzam, Ahmed Y, Badiye, Ashish D, Bagheri, Nasser, Bagherieh, Sara, Bairwa, Mohan, Bakkannavar, Shankar M, Bakshi, Ravleen Kaur, Balchut/Bilchut, Awraris Hailu, Bärnighausen, Till Winfried, Barra, Fabio, Barrow, Amadou, Baskaran, Pritish, Belo, Luis, Bennett, Derrick A, Benseñor, Isabela M, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhalla, Ashish, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhaskar, Sonu, Bhattacharyya, Krittika, Bhojaraja, Vijayalakshmi S, Bintoro, Bagas Suryo, Blokhina, Elena A Elena, Bodicha, Belay Boda Abule, Boloor, Archith, Bosetti, Cristina, Braithwaite, Dejana, Brenner, Hermann, Briko, Nikolay Ivanovich, Brunoni, Andre R, Butt, Zahid A, Cao, Chao, Cao, Yin, Cárdenas, Rosario, Carvalho, Andre F, Carvalho, Márcia, Castaldelli-Maia, Joao Mauricio, Castelpietra, Giulio, Castro-de-Araujo, Luis F S, Cattaruzza, Maria Sofia, Chakraborty, Promit Ananyo, Charan, Jaykaran, Chattu, Vijay Kumar, Chaurasia, Akhilanand, Cherbuin, Nicolas, Chu, Dinh-Toi, Chudal, Nandita, Chung, Sheng-Chia, Churko, Chuchu, Ciobanu, Liliana G, Cirillo, Massimo, Claro, Rafael M, Costanzo, Simona, Cowden, Richard G, Criqui, Michael H, Cruz-Martins, Natália, Culbreth, Garland T, Dachew, Berihun Assefa, Dadras, Omid, Dai, Xiaochen, Damiani, Giovanni, Dandona, Lalit, Dandona, Rakhi, Daniel, Beniam Darge, Danielewicz, Anna, Darega Gela, Jiregna, Davletov, Kairat, de Araujo, Jacyra Azevedo Paiva, de Sá-Junior, Antonio Reis, Debela, Sisay Abebe, Dehghan, Azizallah, Demetriades, Andreas K, Derbew Molla, Meseret, Desai, Rupak, Desta, Abebaw Alemayehu, Dias da Silva, Diana, Diaz, Daniel, Digesa, Lankamo Ena, Diress, Mengistie, Dodangeh, Milad, Dongarwar, Deepa, Dorostkar, Fariba, Dsouza, Haneil Larson, Duko, Bereket, Duncan, Bruce B, Edvardsson, Kristina, Ekholuenetale, Michael, Elgar, Frank J, Elhadi, Muhammed, Elmonem, Mohamed A, Endries, Aman Yesuf, Eskandarieh, Sharareh, Etemadimanesh, Azin, Fagbamigbe, Adeniyi Francis, Fakhradiyev, Ildar Ravisovich, Farahmand, Fatemeh, Farinha, Carla Sofia e Sá, Faro, Andre, Farzadfar, Farshad, Fatehizadeh, Ali, Fauk, Nelsensius Klau, Feigin, Valery L, Feldman, Rachel, Feng, Xiaoqi, Fentaw, Zinabu, Ferrero, Simone, Ferro Desideri, Lorenzo, Filip, Irina, Fischer, Florian, Francis, Joel Msafiri, Franklin, Richard Charles, Gaal, Peter Andras, Gad, Mohamed M, Gallus, Silvano, Galvano, Fabio, Ganesan, Balasankar, Garg, Tushar, Gebrehiwot, Mesfin Gebrehiwot Damtew, Gebremeskel, Teferi Gebru, Gebremichael, Mathewos Alemu, Gemechu, Tadele Regasa, Getacher, Lemma, Getachew, Motuma Erena, Getachew Obsa, Abera, Getie, Asmare, Ghaderi, Amir, Ghafourifard, Mansour, Ghajar, Alireza, Ghamari, Seyyed-Hadi, Ghandour, Lilian A, Ghasemi Nour, Mohammad, Ghashghaee, Ahmad, Ghozy, Sherief, Glozah, Franklin N, Glushkova, Ekaterina Vladimirovna, Godos, Justyna, Goel, Amit, Goharinezhad, Salime, Golechha, Mahaveer, Goleij, Pouya, Golitaleb, Mohamad, Greaves, Felix, Grivna, Michal, Grosso, Giuseppe, Gudayu, Temesgen Worku, Gupta, Bhawna, Gupta, Rajeev, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Hafezi-Nejad, Nima, Haj-Mirzaian, Arvin, Hall, Brian J, Halwani, Rabih, Handiso, Tiilahun Beyene, Hankey, Graeme J, Hariri, Sanam, Haro, Josep Maria, Hasaballah, Ahmed I, Hassanian-Moghaddam, Hossein, Hay, Simon I, Hayat, Khezar, Heidari, Golnaz, Heidari, Mohammad, Hendrie, Delia, Herteliu, Claudiu, Heyi, Demisu Zenbaba, Hezam, Kamal, Hlongwa, Mbuzeleni Mbuzeleni, Holla, Ramesh, Hossain, Md Mahbub, Hossain, Sahadat, Hosseini, Seyed Kianoosh, hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Hu, Guoqing, Huang, Junjie, Hussain, Salman, Ibitoye, Segun Emmanuel, Ilic, Irena M, Ilic, Milena D, Immurana, Mustapha, Irham, Lalu Muhammad, Islam, M Mofizul, Islam, Rakibul M, Islam, Sheikh Mohammed Shariful, Iso, Hiroyasu, Itumalla, Ramaiah, Iwagami, Masao, Jabbarinejad, Roxana, Jacob, Louis, Jakovljevic, Mihajlo, Jamalpoor, Zahra, Jamshidi, Elham, Jayapal, Sathish Kumar, Jayarajah, Umesh Umesh, Jayawardena, Ranil, Jebai, Rime, Jeddi, Seyed Ali, Jema, Alelign Tasew, Jha, Ravi Prakash, Jindal, Har Ashish, Jonas, Jost B, Joo, Tamas, Joseph, Nitin, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Ali, Kabthymer, Robel Hussen, Kamble, Bhushan Dattatray, Kandel, Himal, Kanno, Girum Gebremeskel, Kapoor, Neeti, Karaye, Ibraheem M, Karimi, Salah Eddin, Kassa, Bekalu Getnet, Kaur, Rimple Jeet, Kayode, Gbenga A, Keykhaei, Mohammad, Khajuria, Himanshu, Khalilov, Rovshan, Khan, Imteyaz A, Khan, Moien AB, Kim, Hanna, Kim, Jihee, Kim, Min Seo, Kimokoti, Ruth W, Kivimäki, Mika, Klymchuk, Vitalii, Knudsen, Ann Kristin Skrindo, Kolahi, Ali-Asghar, Korshunov, Vladimir Andreevich, Koyanagi, Ai, Krishan, Kewal, Krishnamoorthy, Yuvaraj, Kumar, G Anil, Kumar, Narinder, Kumar, Nithin, Lacey, Ben, Lallukka, Tea, Lasrado, Savita, Lau, Jerrald, Lee, Sang-woong, Lee, Wei-Chen, Lee, Yo Han, Lim, Lee-Ling, Lim, Stephen S, Lobo, Stany W, Lopukhov, Platon D, Lorkowski, Stefan, Lozano, Rafael, Lucchetti, Giancarlo, Madadizadeh, Farzan, Madureira-Carvalho, Áurea M, Mahjoub, Soleiman, Mahmoodpoor, Ata, Mahumud, Rashidul Alam, Makki, Alaa, Malekpour, Mohammad-Reza, Manjunatha, Narayana, Mansouri, Borhan, Mansournia, Mohammad Ali, Martinez-Raga, Jose, Martinez-Villa, Francisco A, Matzopoulos, Richard, Maulik, Pallab K, Mayeli, Mahsa, McGrath, John J, Meena, Jitendra Kumar, Mehrabi Nasab, Entezar, Menezes, Ritesh G, Mensink, Gert B M, Mentis, Alexios-Fotios A, Meretoja, Atte, Merga, Bedasa Taye, Mestrovic, Tomislav, Miao Jonasson, Junmei, Miazgowski, Bartosz, Micheletti Gomide Nogueira de Sá, Ana Carolina, Miller, Ted R, Mini, GK, Mirica, Andreea, Mirijello, Antonio, Mirmoeeni, Seyyedmohammadsadeq, Mirrakhimov, Erkin M, Misra, Sanjeev, Moazen, Babak, Mobarakabadi, Maryam, Moccia, Marcello, Mohammad, Yousef, Mohammadi, Esmaeil, Mohammadian-Hafshejani, Abdollah, Mohammed, Teroj Abdulrahman, Moka, Nagabhishek, Mokdad, Ali H, Momtazmanesh, Sara, Moradi, Yousef, Mostafavi, Ebrahim, Mubarik, Sumaira, Mullany, Erin C, Mulugeta, Beemnet Tekabe, Murillo-Zamora, Efrén, Murray, Christopher J L, Mwita, Julius C, Naghavi, Mohsen, Naimzada, Mukhammad David, Nangia, Vinay, Nayak, Biswa Prakash, Negoi, Ionut, Negoi, Ruxandra Irina, Nejadghaderi, Seyed Aria, Nepal, Samata, Neupane, Sudan Prasad Prasad, Neupane Kandel, Sandhya, Nigatu, Yeshambel T, Nowroozi, Ali, Nuruzzaman, Khan M, Nzoputam, Chimezie Igwegbe, Obamiro, Kehinde O, Ogbo, Felix Akpojene, Oguntade, Ayodipupo Sikiru, Okati-Aliabad, Hassan, Olakunde, Babayemi Oluwaseun, Oliveira, Gláucia Maria Moraes, Omar Bali, Ahmed, Omer, Emad, Ortega-Altamirano, Doris V, Otoiu, Adrian, Otstavnov, Stanislav S, Oumer, Bilcha, P A, Mahesh, Padron-Monedero, Alicia, Palladino, Raffaele, Pana, Adrian, Panda-Jonas, Songhomitra, Pandey, Anamika, Pandey, Ashok, Pardhan, Shahina, Parekh, Tarang, Park, Eun-Kee, Parry, Charles D H, Pashazadeh Kan, Fatemeh, Patel, Jay, Pati, Siddhartha, Patton, George C, Paudel, Uttam, Pawar, Shrikant, Peden, Amy E, Petcu, Ionela-Roxana, Phillips, Michael R, Pinheiro, Marina, Plotnikov, Evgenii, Pradhan, Pranil Man Singh, Prashant, Akila, Quan, Jianchao, Radfar, Amir, Rafiei, Alireza, Raghav, Pankaja Raghav, Rahimi-Movaghar, Vafa, Rahman, Azizur, Rahman, Md Mosfequr, Rahman, Mosiur, Rahmani, Amir Masoud, Rahmani, Shayan, Ranabhat, Chhabi Lal, Ranasinghe, Priyanga, Rao, Chythra R, Rasali, Drona Prakash, Rashidi, Mohammad-Mahdi, Ratan, Zubair Ahmed, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Renzaho, Andre M N, Rezaei, Negar, Rezaei, Saeid, Rezaeian, Mohsen, Riahi, Seyed Mohammad, Romero-Rodríguez, Esperanza, Roth, Gregory A, Rwegerera, Godfrey M, Saddik, Basema, Sadeghi, Erfan, Sadeghian, Reihaneh, Saeed, Umar, Saeedi, Farhad, Sagar, Rajesh, Sahebkar, Amirhossein, Sahoo, Harihar, Sahraian, Mohammad Ali, Saif-Ur-Rahman, KM, Salahi, Sarvenaz, Salimzadeh, Hamideh, Samy, Abdallah M, Sanmarchi, Francesco, Santric-Milicevic, Milena M, Sarikhani, Yaser, Sathian, Brijesh, Saya, Ganesh Kumar, Sayyah, Mehdi, Schmidt, Maria Inês, Schutte, Aletta Elisabeth, Schwarzinger, Michaël, Schwebel, David C, Seidu, Abdul-Aziz, Senthil Kumar, Nachimuthu, SeyedAlinaghi, SeyedAhmad, Seylani, Allen, Sha, Feng, Shahin, Sarvenaz, Shahraki-Sanavi, Fariba, Shahrokhi, Shayan, Shaikh, Masood Ali, Shaker, Elaheh, Shakhmardanov, Murad Ziyaudinovich, Shams-Beyranvand, Mehran, Sheikhbahaei, Sara, Sheikhi, Rahim Ali, Shetty, Adithi, Shetty, Jeevan K, Shiferaw, Damtew Solomon, Shigematsu, Mika, Shiri, Rahman, Shirkoohi, Reza, Shivakumar, K M, Shivarov, Velizar, Shobeiri, Parnian, Shrestha, Roman, Sidemo, Negussie Boti, Sigfusdottir, Inga Dora, Silva, Diego Augusto Santos, Silva, Natacha Torres da, Singh, Jasvinder A, Singh, Surjit, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sleet, David A, Solmi, Marco, SOLOMON, YONATAN, Song, Suhang, Song, Yimeng, Sorensen, Reed J D, Soshnikov, Sergey, Soyiri, Ireneous N, Stein, Dan J, Subba, Sonu Hangma, Szócska, Miklós, Tabarés-Seisdedos, Rafael, Tabuchi, Takahiro, Taheri, Majid, Tan, Ker-Kan, Tareke, Minale, Tarkang, Elvis Enowbeyang, Temesgen, Gebremaryam, Temesgen, Worku Animaw, Temsah, Mohamad-Hani, Thankappan, Kavumpurathu Raman, Thapar, Rekha, Thomas, Nikhil Kenny, Tiruneh, Chalachew, Todorovic, Jovana, Torrado, Marco, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Tran, Mai Thi Ngoc, Trias-Llimós, Sergi, Tripathy, Jaya Prasad, Vakilian, Alireza, Valizadeh, Rohollah, Varmaghani, Mehdi, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vos, Theo, Wagaye, Birhanu, Waheed, Yasir, Walde, Mandaras Tariku, Wang, Cong, Wang, Yanzhong, Wang, Yuan-Pang, Westerman, Ronny, Wickramasinghe, Nuwan Darshana, Wubetu, Abate Dargie, Xu, Suowen, Yamagishi, Kazumasa, Yang, Lin, Yesera, Gesila Endashaw E, Yigit, Arzu, Yiğit, Vahit, Yimaw, Ayenew Engida Ayenew Engida, Yon, Dong Keon, Yonemoto, Naohiro, Yu, Chuanhua, Zadey, Siddhesh, Zahir, Mazyar, Zare, Iman, Zastrozhin, Mikhail Sergeevich, Zastrozhina, Anasthasia, Zhang, Zhi-Jiang, Zhong, Chenwen, Zmaili, Mohammad, Zuniga, Yves Miel H, and Gakidou, Emmanuela
- Abstract
The health risks associated with moderate alcohol consumption continue to be debated. Small amounts of alcohol might lower the risk of some health outcomes but increase the risk of others, suggesting that the overall risk depends, in part, on background disease rates, which vary by region, age, sex, and year.
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- 2022
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22. Estimates, trends, and drivers of the global burden of type 2 diabetes attributable to PM2·5air pollution, 1990–2019: an analysis of data from the Global Burden of Disease Study 2019
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Burkart, Katrin, Causey, Kate, Cohen, Aaron J, Wozniak, Sarah S, Salvi, Devashri Digvijay, Abbafati, Cristiana, Adekanmbi, Victor, Adsuar, Jose C, Ahmadi, Keivan, Alahdab, Fares, Al-Aly, Ziyad, Alipour, Vahid, Alvis-Guzman, Nelson, Amegah, Adeladza Kofi, Andrei, Catalina Liliana, Andrei, Tudorel, Ansari, Fereshteh, Arabloo, Jalal, Aremu, Olatunde, Aripov, Timur, Babaee, Ebrahim, Banach, Maciej, Barnett, Anthony, Bärnighausen, Till Winfried, Bedi, Neeraj, Behzadifar, Masoud, Béjot, Yannick, Bennett, Derrick A, Bensenor, Isabela M, Bernstein, Robert S, Bhattacharyya, Krittika, Bijani, Ali, Biondi, Antonio, Bohlouli, Somayeh, Breitner, Susanne, Brenner, Hermann, Butt, Zahid A, Cámera, Luis Alberto, Cantu-Brito, Carlos, Carvalho, Felix, Cerin, Ester, Chattu, Vijay Kumar, Chauhan, Bal Govind, Choi, Jee-Young Jasmine, Chu, Dinh-Toi, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Daryani, Ahmad, Davletov, Kairat, de Courten, Barbora, Demeke, Feleke Mekonnen, Denova-Gutiérrez, Edgar, Dharmaratne, Samath Dhamminda, Dhimal, Meghnath, Diaz, Daniel, Djalalinia, Shirin, Duncan, Bruce B, El Sayed Zaki, Maysaa, Eskandarieh, Sharareh, Fareed, Mohammad, Farzadfar, Farshad, Fattahi, Nazir, Fazlzadeh, Mehdi, Fernandes, Eduarda, Filip, Irina, Fischer, Florian, Foigt, Nataliya A, Freitas, Marisa, Ghashghaee, Ahmad, Gill, Paramjit Singh, Ginawi, Ibrahim Abdelmageed, Gopalani, Sameer Vali, Guo, Yuming, Gupta, Rajat Das, Habtewold, Tesfa Dejenie, Hamadeh, Randah R, Hamidi, Samer, Hankey, Graeme J, Hasanpoor, Edris, Hassen, Hamid Yimam, Hay, Simon I, Heibati, Behzad, Hole, Michael K, Hossain, Naznin, Househ, Mowafa, Irvani, Seyed Sina Naghibi, Jaafari, Jalil, Jakovljevic, Mihajlo, Jha, Ravi Prakash, Jonas, Jost B, Jozwiak, Jacek Jerzy, Kasaeian, Amir, Kaydi, Neda, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khan, Ejaz Ahmad, Khan, Junaid, Khan, Md Nuruzzaman, Khatab, Khaled, Khater, Amir M, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Adnan, Kivimäki, Mika, Knibbs, Luke D, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Kuate Defo, Barthelemy, Kugbey, Nuworza, Lauriola, Paolo, Lee, Paul H, Leili, Mostafa, Lewycka, Sonia, Li, Shanshan, Lim, Lee-Ling, Linn, Shai, Liu, Yong, Lorkowski, Stefan, Mahasha, Phetole Walter, Mahotra, Narayan B, Majeed, Azeem, Maleki, Afshin, Malekzadeh, Reza, Mamun, Abdullah A, Manafi, Navid, Martini, Santi, Meharie, Birhanu Geta, Menezes, Ritesh G, Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Miller, Ted R, Mini, GK, Mirica, Andreea, Mirrakhimov, Erkin M, Mohajer, Bahram, Mohammed, Shafiu, Mohan, Viswanathan, Mokdad, Ali H, Monasta, Lorenzo, Moraga, Paula, Morrison, Shane Douglas, Mueller, Ulrich Otto, Mukhopadhyay, Satinath, Mustafa, Ghulam, Muthupandian, Saravanan, Naik, Gurudatta, Nangia, Vinay, Ndwandwe, Duduzile Edith, Negoi, Ruxandra Irina, Ningrum, Dina Nur Anggraini, Noubiap, Jean Jacques, Ogbo, Felix Akpojene, Olagunju, Andrew T, Onwujekwe, Obinna E, Ortiz, Alberto, Owolabi, Mayowa O, P A, Mahesh, Panda-Jonas, Songhomitra, Park, Eun-Kee, Pashazadeh Kan, Fatemeh, Pirsaheb, Meghdad, Postma, Maarten J, Pourjafar, Hadi, Radfar, Amir, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahman, Muhammad Aziz, Rai, Rajesh Kumar, Ranabhat, Chhabi Lal, Raoofi, Samira, Rawal, Lal, Renzaho, Andre M N, Rezapour, Aziz, Ribeiro, Daniela, Roever, Leonardo, Ronfani, Luca, Sabour, Siamak, Saddik, Basema, Sadeghi, Ehsan, Saeedi Moghaddam, Sahar, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Salimzadeh, Hamideh, Salvi, Sundeep Santosh, Samy, Abdallah M, Sanabria, Juan, Sarmiento-Suárez, Rodrigo, Sathish, Thirunavukkarasu, Schmidt, Maria Inês, Schutte, Aletta Elisabeth, Sepanlou, Sadaf G, Shaikh, Masood Ali, Sharafi, Kiomars, Sheikh, Aziz, Shigematsu, Mika, Shiri, Rahman, Shirkoohi, Reza, Shuval, Kerem, Soyiri, Ireneous N, Tabarés-Seisdedos, Rafael, Tefera, Yonatal Mesfin, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Thankappan, Kavumpurathu Raman, Topor-Madry, Roman, Tudor Car, Lorainne, Ullah, Irfan, Vacante, Marco, Valdez, Pascual R, Vasankari, Tommi Juhani, Violante, Francesco S, Waheed, Yasir, Wolfe, Charles D A, Yamada, Tomohide, Yonemoto, Naohiro, Yu, Chuanhua, Zaman, Sojib Bin, Zhang, Yunquan, Zodpey, Sanjay, Lim, Stephen S, Stanaway, Jeffrey D, and Brauer, Michael
- Abstract
Experimental and epidemiological studies indicate an association between exposure to particulate matter (PM) air pollution and increased risk of type 2 diabetes. In view of the high and increasing prevalence of diabetes, we aimed to quantify the burden of type 2 diabetes attributable to PM2·5originating from ambient and household air pollution.
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- 2022
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23. Trajectories of Worktime Control From Midlife to Retirement and Working Beyond Retirement Age
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Virtanen, Marianna, Myllyntausta, Saana, Kauppi, Maarit, Kivimäki, Mika, Pentti, Jaana, Ervasti, Jenni, Prakash, K C, Vahtera, Jussi, and Stenholm, Sari
- Abstract
The extent to which long-term individual-oriented flexibility in working hours is associated with working beyond retirement age is not known. The aims of the present study were to identify trajectories of worktime control (WTC) and to examine whether the membership of WTC trajectories was associated with working beyond individual’s pensionable age. A total of 1,953 older employees participated in the study and had data up to 16 years before pensionable age. Group-based latent trajectory modeling was used to identify WTC trajectories and Cox proportional hazard regression models were used to examine the associations of WTC trajectories with duration of employment. Seven trajectories described WTC: “Stable very low” (7%), “Stable low” (21%), “Declined” (12%), “Stable mid-low” (28%), “Improved” (10%), “Stable high” (16%), and “Stable very high” (5%). When compared with the lowest WTC trajectory groups, trajectories of “Stable high/very high” (hazard ratio [HR] 1.34, 95% confidence interval [CI] 1.17–1.54) and “Improved” WTC (HR 1.49, 95% CI 1.25–1.78) were associated with longer duration of employment. Although the memberships of the “Stable high/very high” and “Improved” WTC trajectories correlated with gender, marital status, occupational position, and self-rated health, the association between WTC and duration of employment was not fully confounded or mediated by these factors. These findings support the hypothesis that having improved or constantly high control over working times from midlife to retirement age may prolong working lives at retirement age.
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- 2022
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24. Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019
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Armocida, Benedetta, Monasta, Lorenzo, Sawyer, Susan, Bustreo, Flavia, Segafredo, Giulia, Castelpietra, Giulio, Ronfani, Luca, Pasovic, Maja, Hay, Simon, Armocida, Benedetta, Monasta, Lorenzo, Sawyer, Susan M, Bustreo, Flavia, Segafredo, Giulia, Castelpietra, Giulio, Ronfani, Luca, Pasovic, Maja, Hay, Simon I, Abila, Derrick Bary, Abolhassani, Hassan, Accrombessi, Manfred Mario Kokou, Adekanmbi, Victor, Ahmadi, Keivan, Al Hamad, Hanadi, Aldeyab, Mamoon A, Al-Jumaily, Adel, Ancuceanu, Robert, Andrei, Catalina Liliana, Andrei, Tudorel, Arumugam, Ashokan, Attia, Sameh, Aujayeb, Avinash, Ausloos, Marcel, Baker, Jennifer L, Barone-Adesi, Francesco, Barra, Fabio, Barteit, Sandra, Basu, Sanjay, Baune, Bernhard T, Béjot, Yannick, Belo, Luis, Bennett, Derrick A, Bikbov, Boris, Bikov, Andras, Blyuss, Oleg, Breitner, Susanne, Brenner, Hermann, Carreras, Giulia, Carvalho, Márcia, Catapano, Alberico L, Chandan, Joht Singh, Charalampous, Periklis, Chen, Simiao, Conde, Joao, Cruz-Martins, Natália, Damiani, Giovanni, Dastiridou, Anna, de la Torre-Luque, Alejandro, Dianatinasab, Mostafa, Dias da Silva, Diana, Douiri, Abdel, Dragioti, Elena, Engelbert Bain, Luchuo, Fagbamigbe, Adeniyi Francis, Fereshtehnejad, Seyed-Mohammad, Ferrara, Pietro, Ferreira de Oliveira, José Miguel P, Ferrero, Simone, Ferro Desideri, Lorenzo, Fischer, Florian, Fonseca, Diogo A, Gaewkhiew, Piyada, Gaihre, Santosh, Gallus, Silvano, Gaspar Fonseca, Mariana, Gill, Paramjit Singh, Glasbey, James C, Gorini, Giuseppe, Gupta, Vijai Kumar, Gurara, Mekdes Kondale, Haro, Josep Maria, Hasan, M Tasdik, Havmoeller, Rasmus J, Heibati, Behzad, Hellemons, Merel E, Herteliu, Claudiu, Hussain, Salman, Isola, Gaetano, Johnson, Olatunji, Jonas, Jost B, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Zubair, Karch, André, Kauppila, Joonas H, Kayode, Gbenga A, Khan, Moien AB, Khatab, Khaled, Kivimäki, Mika, Klugar, Miloslav, Klugarová, Jitka, Koly, Kamrun Nahar, Koyanagi, Ai, Kurmi, Om P, Kusuma, Dian, La Vecchia, Carlo, Lacey, Ben, Lallukka, Tea, Lamnisos, Demetris, Langguth, Berthold, Larsson, Anders O, Lauriola, Paolo, Lee, Paul H, Leonardi, Matilde, Li, An, Linehan, Christine, López-Bueno, Rubén, Lorkowski, Stefan, Loureiro, Joana A, Lunevicius, Raimundas, Magee, Laura A, Magnani, Francesca Giulia, Majeed, Azeem, Makris, Konstantinos Christos, Mathioudakis, Alexander G, Mathur, Manu Raj, McGrath, John J, Menezes, Ritesh G, Mentis, Alexios-Fotios A, Meretoja, Atte, Mestrovic, Tomislav, Miao Jonasson, Junmei, Miazgowski, Tomasz, Mirica, Andreea, Moccia, Marcello, Mohammed, Shafiu, Molokhia, Mariam, Mondello, Stefania, Mueller, Ulrich Otto, Mulita, Francesk, Munblit, Daniel, Negoi, Ionut, Negoi, Ruxandra Irina, Nena, Evangelia, Noor, Nurulamin M, Nowak, Christoph, Ntaios, George, Nwatah, Vincent Ebuka, Oancea, Bogdan, Oguntade, Ayodipupo Sikiru, Ortiz, Alberto, Otoiu, Adrian, Padron-Monedero, Alicia, Palladino, Raffaele, Pana, Adrian, Panagiotakos, Demosthenes, Panda-Jonas, Songhomitra, Pardhan, Shahina, Patel, Jay, Pedersini, Paolo, Peñalvo, José L, Pensato, Umberto, Pereira, Renato B, Perico, Norberto, Petcu, Ionela-Roxana, Polinder, Suzanne, Postma, Maarten J, Rabiee, Mohammad, Rabiee, Navid, Raggi, Alberto, Rahimzadeh, Shadi, Rawaf, David Laith, Rawaf, Salman, Rehman, Faizan Ur, Remuzzi, Giuseppe, Riad, Abanoub, Rodriguez, Alina, Sacco, Simona, Saeb, Mohammad Reza, Safdarian, Mahdi, Sathian, Brijesh, Sattin, Davide, Saxena, Sonia, Scarmeas, Nikolaos, Schlee, Winfried, Schwendicke, Falk, Shamsizadeh, Morteza, Sharew, Nigussie Tadesse, Shiri, Rahman, Shivalli, Siddharudha, Shivarov, Velizar, Silva, João Pedro, Simpson, Colin R, Skou, Søren T, Socea, Bogdan, Soyiri, Ireneous N, Steiropoulos, Paschalis, Straif, Kurt, Sun, Xiaohui, Tabarés-Seisdedos, Rafael, Thiyagarajan, Arulmani, Topouzis, Fotis, Tovani-Palone, Marcos Roberto, Truelsen, Thomas Clement, Unim, Brigid, Van den Eynde, Jef, Vasankari, Tommi Juhani, Veroux, Massimiliano, Villafaina, Santos, Vinko, Matej, Violante, Francesco S, Volovici, Victor, Wang, Yanzhong, Westerman, Ronny, Yadegarfar, Mohammad Esmaeil, Yaya, Sanni, Zadnik, Vesna, Zumla, Alimuddin, Perel, Pablo, Beran, David, Perel, Pablo, and Beran, David
- Abstract
Disability and mortality burden of non-communicable diseases (NCDs) have risen worldwide; however, the NCD burden among adolescents remains poorly described in the EU.
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- 2022
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25. The relationships between hippocampal cerebrovascular reactivity, hippocampal volume, and episodic memory in healthy ageing.
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Wang, Congxiyu, Jobbins, Lucy, Reid, Graham, Hobden, Georgina, Mackay, Clare, Ebmeier, Klaus P, Rieger, Sebastian, Patel, Raihaan, Kivimäki, Mika, Singh‐Manoux, Archana, Bulte, Daniel, and Suri, Sana
- Abstract
Background: Cerebrovascular biomarkers such as cerebrovascular reactivity (CVR) have previously been associated with episodic memory. However, the relationship between memory and regional CVR within the hippocampus is not well studied. Moreover, whether this association is affected by hippocampal volume remains to be investigated. This study investigated the associations between hippocampal physiology, structure, and memory in ageing. Method: Data from 104 participants (Age: Mean = 77±4.9 years) of the ongoing Oxford Heart and Brain Study was analysed for this study. CVR was assessed by a compensatory change in the blood oxygenation level dependent magnetic resonance imaging (MRI) signal in response to a 5% CO2 challenge, hippocampus volume was measured by structural MRI, and episodic memory was assessed with the Hopkins Verbal Learning Test Revised (HVLT‐R). Result: Mean hippocampal CVR decreased with age (β = ‐0.004, p = 0.006). Mean hippocampal CVR was positively associated with mean hippocampal volume (β = 0.11, p = 0.010), and this association was driven by the left hippocampus after correcting for age and sex. Higher hippocampal CVR was also associated with better performance on the HVLT (β = 13.8, p = 0.035). This association was fully mediated by hippocampal volume, suggesting a path from cerebrovascular reactivity to episodic memory (Sobel's z = 2.16, p = 0.030, see Figure 1). Conclusion: This study presents novel findings showing that hippocampal CVR was associated with episodic memory, and this association was mediated by hippocampal volume. This suggests a pathway by which impairments in hippocampal CVR are associated with worse episodic memory via smaller hippocampal volumes. [ABSTRACT FROM AUTHOR]
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- 2023
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26. Phenotypic frailty and multimorbidity are independent 18-year mortality risk indicators in older men: The Helsinki Businessmen Study (HBS).
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Strandberg, Timo E., Lindström, Linda, Jyväkorpi, Satu, Urtamo, Annele, Pitkälä, Kaisu H., and Kivimäki, Mika
- Abstract
Key summary points: Objective: Multimorbidity, phenotypic prefrailty and frailty are frequent in ageing populations Findings: This long-term follow-up of home-dwelling older men reveals the relationship of phenotypic frailty to long-term prognosis, independently of the presence of significant chronic diseases and disability. Message: Assessment of phenotypic frailty and already prefrailty provides extra clinical value for the assessment of prognosis in old age. Purpose: Multimorbidity, prefrailty, and frailty are frequent in ageing populations, but their independent relationships to long-term prognosis in home-dwelling older people are not well recognised. Methods: In the Helsinki Businessmen Study (HBS) men with high socioeconomic status (born 1919–1934, n = 3490) have been followed-up from midlife. In 2000, multimorbidity (≥ 2 conditions), phenotypic prefrailty and frailty were determined in 1365 home-dwelling men with median age of 73 years). Disability was assessed as a possible confounder. 18-year mortality follow-up was established from registers and Cox regression used for analyses. Results: Of the men, 433 (31.7%) were nonfrail and without multimorbidity at baseline (reference group), 500 (36.6%) and 82 (6.0%) men had prefrailty or frailty, respectively, without multimorbidity, 84 (6.2%) men had multimorbidity only, and 201 (14.7%) and 65 (4.8%) men had prefrailty or frailty together with multimorbidity. Only 30 (2.2%) and 86 (6.3%) showed signs of ADL or mobility disability. In the fully adjusted analyses (including ADL disability, mental and cognitive status) of 18-year mortality, frailty without multimorbidity (hazard ratio 1.62, 95% confidence interval 1.13–2.31) was associated with similar mortality risk than multimorbidity without frailty (1.55, 1.17–2.06). The presence of both frailty and multimorbidity indicated a strong mortality risk (2.93, 2.10–4.07). Conclusion: Although multimorbidity is generally considered a substantial health problem, our long-term observational study emphasises that phenotypic frailty alone, independently of disability, may be associated with a similar risk, and a combination of multimorbidity and frailty is an especially strong predictor of mortality. [ABSTRACT FROM AUTHOR]
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- 2021
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27. Contribution of 20-year body mass index and waist circumference history to poor cardiometabolic health in overweight/obese and normal weight adults: A cohort study.
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Robson, Ellie, Norris, Tom, Costa, Silvia, Kivimäki, Mika, Hamer, Mark, and Johnson, William
- Abstract
Background and Aims: We investigated the associations of 20-year body mass index (BMI) and waist circumference (WC) histories with risk of being 1) metabolically unhealthy overweight/obese (MUOO) vs metabolically healthy overweight/obese (MHOO) and 2) metabolically unhealthy normal weight (MUNW) vs metabolically healthy normal weight (MHNW).Methods and Results: Participants comprised 3018 adults (2280 males; 738 females) with BMI and WC measured, every ~5 years, in 1991-1994, 1997-1999, 2002-2004, 2007-2009, and 2012-2013. Mean age in 2012-2013 was 69.3 years, with a range of 59.7-82.2 years. Duration was defined as the number of times a person was overweight/obese (or centrally obese) across the 5 visits, severity as each person's mean BMI (or WC), and variability as the within-person standard deviation of BMI (or WC). At the 2013-2013 visit, participants were categorised based on their weight (overweight/obese or normal weight; body mass index (BMI) ≥25 kg/m2) and health status (healthy or unhealthy; two or more of hypertension, low high-density lipoprotein cholesterol, high triglycerides, high glucose, and high homeostatic model assessment of insulin resistance). Logistic regression was used to estimate associations with the risk of being MUNW (reference MHNW) and MUOO (reference MHOO) at the last visit. BMI and WC severity were each related to increased risk of being unhealthy, with estimates being stronger among normal weight than overweight/obese adults. The estimates for variability exposures became null upon adjustment for severity. Individuals who were overweight/obese at all 5 time points had a 1.60 (0.96-2.67) times higher risk of being MUOO than MHOO compared to those who were only overweight/obese at one (i.e., the last) time point. The corresponding estimate for central obesity was 4.20 (2.88-6.12). Greater duration was also related to higher risk of MUNW than MHNW.Conclusion: Being overweight/obese yet healthy seems to be partially attributable to lower exposure to adiposity across 20 years of adulthood. The results highlight the importance of maintaining optimum and stable BMI and WC, both in adults who become and do not become overweight/obese. [ABSTRACT FROM AUTHOR]- Published
- 2021
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28. Association of plasma gelsolin with frailty phenotype and mortality among octogenarian community-dwelling men: a cohort study
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Strandberg, Timo E., Levinson, Susan L., DiNubile, Mark J., Jyväkorpi, Satu, and Kivimäki, Mika
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Background: Biomarkers are needed for frailty, a common phenotype often associated with muscle loss in older people. Plasma gelsolin (pGSN) is a protein largely synthesized and secreted by skeletal muscle. Aims: To investigate whether pGSN could be a biomarker of the frailty phenotype and predict mortality. Methods: A homogenous cohort of males (born 1919–1934, baseline n= 3490) has been followed since the 1960s. In 2010/11, frailty phenotypes by modified Fried criteria were assessed. pGSN was measured in a convenience subset (n= 469, mean age 83) and re-measured in survivors (n= 127) in 2017. Mortality through December 31, 2018 was retrieved from national registers. Regression models were used for analyses. Results: Of 469 males, 152 (32.4%) were robust, 284 (60.6%) prefrail, and 33 (7.0%) frail in 2010/11. There was a graded (p= 0.018) association between pGSN (mean 58.1 ug/mL, SD 9.3) and frailty. After multivariable adjustment, higher pGSN levels were associated with lower odds of having contemporaneous phenotypic prefrailty (OR per 1 SD 0.73, 95% CI 0.58–0.92) and frailty (OR per 1 SD 0.70, 95% CI 0.44–1.11). By 2018, 179 males (38.2%) had died, and higher baseline pGSN predicted a lower 7-year mortality rate (HR per 1 SD 0.85, 95% CI 0.72–1.00). pGSN concentrations in 2010/11 and 2017 were correlated (n= 127, r= 0.34, p< 0.001). Discussion: Higher baseline pGSN concentrations were associated with a persistently robust phenotype and lower mortality rate over 7 years in a cohort of octogenarian males with high socioeconomic status and may be a promising laboratory biomarker for the development of a frailty phenotype.
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- 2022
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29. Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study
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Kivimäki, Mika, Strandberg, Timo, Pentti, Jaana, Nyberg, Solja T, Frank, Philipp, Jokela, Markus, Ervasti, Jenni, Suominen, Sakari B, Vahtera, Jussi, Sipilä, Pyry N, Lindbohm, Joni V, and Ferrie, Jane E
- Abstract
The accumulation of disparate diseases in complex multimorbidity makes prevention difficult if each disease is targeted separately. We aimed to examine obesity as a shared risk factor for common diseases, determine associations between obesity-related diseases, and examine the role of obesity in the development of complex multimorbidity (four or more comorbid diseases).
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- 2022
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30. Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019
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Cousin, Ewerton, Duncan, Bruce B, Stein, Caroline, Ong, Kanyin Liane, Vos, Theo, Abbafati, Cristiana, Abbasi-Kangevari, Mohsen, Abdelmasseh, Michael, Abdoli, Amir, Abd-Rabu, Rami, Abolhassani, Hassan, Abu-Gharbieh, Eman, Accrombessi, Manfred Mario Kokou, Adnani, Qorinah Estiningtyas Sakilah, Afzal, Muhammad Sohail, Agarwal, Gina, Agrawaal, Krishna K, Agudelo-Botero, Marcela, Ahinkorah, Bright Opoku, Ahmad, Sajjad, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadi, Sepideh, Ahmadi, Ali, Ahmed, Ali, Ahmed Salih, Yusra, Akande-Sholabi, Wuraola, Akram, Tayyaba, Al Hamad, Hanadi, Al-Aly, Ziyad, Alcalde-Rabanal, Jacqueline Elizabeth, Alipour, Vahid, Aljunid, Syed Mohamed, Al-Raddadi, Rajaa M, Alvis-Guzman, Nelson, Amini, Saeed, Ancuceanu, Robert, Andrei, Tudorel, Andrei, Catalina Liliana, Anjana, Ranjit Mohan, Ansar, Adnan, Antonazzo, Ippazio Cosimo, Antony, Benny, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Arizmendi, Damian, Armocida, Benedetta, Artamonov, Anton A, Arulappan, Judie, Aryan, Zahra, Asgari, Samaneh, Ashraf, Tahira, Astell-Burt, Thomas, Atorkey, Prince, Atout, Maha Moh'd Wahbi, Ayanore, Martin Amogre, Badiye, Ashish D, Baig, Atif Amin, Bairwa, Mohan, Baker, Jennifer L, Baltatu, Ovidiu Constantin, Banik, Palash Chandra, Barnett, Anthony, Barone, Mark Thomaz Ugliara, Barone-Adesi, Francesco, Barrow, Amadou, Bedi, Neeraj, Belete, Rebuma, Belgaumi, Uzma Iqbal, Bell, Arielle Wilder, Bennett, Derrick A, Bensenor, Isabela M, Beran, David, Bhagavathula, Akshaya Srikanth, Bhaskar, Sonu, Bhattacharyya, Krittika, Bhojaraja, Vijayalakshmi S, Bijani, Ali, Bikbov, Boris, Birara, Setognal, Bodolica, Virginia, Bonny, Aime, Brenner, Hermann, Briko, Nikolay Ivanovich, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cámera, Luis Alberto, Campos-Nonato, Ismael R, Cao, Yin, Cao, Chao, Cerin, Ester, Chakraborty, Promit Ananyo, Chandan, Joht Singh, Chattu, Vijay Kumar, Chen, Simiao, Choi, Jee-Young Jasmine, Choudhari, Sonali Gajanan, Chowdhury, Enayet Karim, Chu, Dinh-Toi, Corso, Barbara, Dadras, Omid, Dai, Xiaochen, Damasceno, Albertino Antonio Moura, Dandona, Lalit, Dandona, Rakhi, Dávila-Cervantes, Claudio Alberto, De Neve, Jan-Walter, Denova-Gutiérrez, Edgar, Dhamnetiya, Deepak, Diaz, Daniel, Ebtehaj, Sanam, Edinur, Hisham Atan, Eftekharzadeh, Sahar, El Sayed, Iman, Elgendy, Islam Y, Elhadi, Muhammed, Elmonem, Mohamed A, Faisaluddin, Mohammed, Farooque, Umar, Feng, Xiaoqi, Fernandes, Eduarda, Fischer, Florian, Flood, David, Freitas, Marisa, Gaal, Peter Andras, Gad, Mohamed M, Gaewkhiew, Piyada, Getacher, Lemma, Ghafourifard, Mansour, Ghanei Gheshlagh, Reza, Ghashghaee, Ahmad, Ghith, Nermin, Ghozali, Ghozali, Gill, Paramjit Singh, Ginawi, Ibrahim Abdelmageed, Glushkova, Ekaterina Vladimirovna, Golechha, Mahaveer, Gopalani, Sameer Vali, Guimarães, Rafael Alves, Gupta, Rajat Das, Gupta, Rajeev, Gupta, Vivek Kumar, Gupta, Veer Bala, Gupta, Sapna, Habtewold, Tesfa Dejenie, Hafezi-Nejad, Nima, Halwani, Rabih, Hanif, Asif, Hankey, Graeme J, Haque, Shafiul, Hasaballah, Ahmed I, Hasan, Syed Shahzad, Hashi, Abdiwahab, Hassanipour, Soheil, Hay, Simon I, Hayat, Khezar, Heidari, Mohammad, Hossain, Mohammad Bellal Hossain, Hossain, Sahadat, Hosseini, Mostafa, Hoveidamanesh, Soodabeh, Huang, Junjie, Humayun, Ayesha, Hussain, Rabia, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ikuta, Kevin S, Inbaraj, Leeberk Raja, Iqbal, Usman, Islam, Md Shariful, Islam, Sheikh Mohammed Shariful, Islam, Rakibul M, Ismail, Nahlah Elkudssiah, Isola, Gaetano, Itumalla, Ramaiah, Iwagami, Masao, Iyamu, Ihoghosa Osamuyi, Jahani, Mohammad Ali, Jakovljevic, Mihajlo, Jayawardena, Ranil, Jha, Ravi Prakash, John, Oommen, Jonas, Jost B, Joo, Tamas, Kabir, Ali, Kalhor, Rohollah, Kamath, Ashwin, Kanchan, Tanuj, Kandel, Himal, Kapoor, Neeti, Kayode, Gbenga A, Kebede, Sewnet Adem, Keshavarz, Pedram, Keykhaei, Mohammad, Khader, Yousef Saleh, Khajuria, Himanshu, Khan, Moien AB, Khan, Md Nuruzzaman, Khan, Maseer, Khater, Amir M, Khoja, Tawfik Ahmed Muthafer, Khubchandani, Jagdish, Kim, Min Seo, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Sezer, Kisa, Adnan, Kivimäki, Mika, Korshunov, Vladimir Andreevich, Korzh, Oleksii, Koyanagi, Ai, Krishan, Kewal, Kuate Defo, Barthelemy, Kumar, G Anil, Kumar, Nithin, Kusuma, Dian, La Vecchia, Carlo, Lacey, Ben, Larsson, Anders O, Lasrado, Savita, Lee, Wei-Chen, Lee, Chiachi Bonnie, Lee, Paul H, Lee, Shaun Wen Huey, Li, Ming-Chieh, Lim, Stephen S, Lim, Lee-Ling, Lucchetti, Giancarlo, Majeed, Azeem, Malik, Ahmad Azam, Mansouri, Borhan, Mantovani, Lorenzo Giovanni, Martini, Santi, Mathur, Prashant, McAlinden, Colm, Mehedi, Nafiul, Mekonnen, Teferi, Menezes, Ritesh G, Mersha, Amanual Getnet, Miao Jonasson, Junmei, Miazgowski, Tomasz, Michalek, Irmina Maria, Mirica, Andreea, Mirrakhimov, Erkin M, Mirza, Agha Zeeshan, Mithra, Prasanna, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mohammed, Arif, Mokdad, Ali H, Molokhia, Mariam, Monasta, Lorenzo, Moni, Mohammad Ali, Moradpour, Farhad, Moradzadeh, Rahmatollah, Mostafavi, Ebrahim, Mueller, Ulrich Otto, Murray, Christopher J L, Mustafa, Ahmad, Nagel, Gabriele, Nangia, Vinay, Naqvi, Atta Abbas, Nayak, Biswa Prakash, Nazari, Javad, Ndejjo, Rawlance, Negoi, Ruxandra Irina, Neupane Kandel, Sandhya, Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Noubiap, Jean Jacques, Nowak, Christoph, Oancea, Bogdan, Odukoya, Oluwakemi Ololade, Oguntade, Ayodipupo Sikiru, Ojo, Temitope T, Olagunju, Andrew T, Onwujekwe, Obinna E, Ortiz, Alberto, Owolabi, Mayowa O, Palladino, Raffaele, Panda-Jonas, Songhomitra, Pandi-Perumal, Seithikurippu R, Pardhan, Shahina, Parekh, Tarang, Parvizi, Mojtaba, Pepito, Veincent Christian Filipino, Perianayagam, Arokiasamy, Petcu, Ionela-Roxana, Pilania, Manju, Podder, Vivek, Polibin, Roman V, Postma, Maarten J, Prashant, Akila, Rabiee, Navid, Rabiee, Mohammad, Rahimi-Movaghar, Vafa, Rahman, Muhammad Aziz, Rahman, Md. Mosfequr, Rahman, Mosiur, Rahmawaty, Setyaningrum, Rajai, Nazanin, Ram, Pradhum, Rana, Juwel, Ranabhat, Kamal, Ranasinghe, Priyanga, Rao, Chythra R, Rao, Satish, Rawaf, Salman, Rawaf, David Laith, Rawal, Lal, Renzaho, Andre M N, Rezaei, Nima, Rezapour, Aziz, Riahi, Seyed Mohammad, Ribeiro, Daniela, Rodriguez, Jefferson Antonio Buendia, Roever, Leonardo, Rohloff, Peter, Rwegerera, Godfrey M, Ryan, Paul MacDaragh, Saber-Ayad, Maha Mohamed, Sabour, Siamak, Saddik, Basema, Saeedi Moghaddam, Sahar, Sahebkar, Amirhossein, Sahoo, Harihar, Saif-Ur-Rahman, KM, Salimzadeh, Hamideh, Samaei, Mehrnoosh, Sanabria, Juan, Santric-Milicevic, Milena M, Sathian, Brijesh, Sathish, Thirunavukkarasu, Schlaich, Markus P, Seidu, Abdul-Aziz, Šekerija, Mario, Senthil Kumar, Nachimuthu, Seylani, Allen, Shaikh, Masood Ali, Shamshad, Hina, Shawon, Md Shajedur Rahman, Sheikhbahaei, Sara, Shetty, Jeevan K, Shiri, Rahman, Shivakumar, K M, Shuval, Kerem, Singh, Jasvinder A, Singh, Ambrish, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sofi-Mahmudi, Ahmad, Soheili, Amin, Sun, Jing, Szerencsés, Viktória, Szócska, Miklós, Tabarés-Seisdedos, Rafael, Tadbiri, Hooman, Tadesse, Eyayou Girma, Tariqujjaman, Md., Thankappan, Kavumpurathu Raman, Thapar, Rekha, Thomas, Nihal, Timalsina, Binod, Tobe-Gai, Ruoyan, Tonelli, Marcello, Tovani-Palone, Marcos Roberto, Tran, Bach Xuan, Tripathy, Jaya Prasad, Tudor Car, Lorainne, Tusa, Biruk Shalmeno, Uddin, Riaz, Upadhyay, Era, Valadan Tahbaz, Sahel, Valdez, Pascual R, Vasankari, Tommi Juhani, Verma, Madhur, Villalobos-Daniel, Victor E, Vladimirov, Sergey Konstantinovitch, Vo, Bay, Vu, Giang Thu, Vukovic, Rade, Waheed, Yasir, Wamai, Richard G, Werdecker, Andrea, Wickramasinghe, Nuwan Darshana, Winkler, Andrea Sylvia, Wubishet, Befikadu Legesse, Xu, Xiaoyue, Xu, Suowen, Yahyazadeh Jabbari, Seyed Hossein, Yatsuya, Hiroshi, Yaya, Sanni, Yazie, Taklo Simeneh Yazie, Yi, Siyan, Yonemoto, Naohiro, Yunusa, Ismaeel, Zadey, Siddhesh, Zaman, Sojib Bin, Zamanian, Maryam, Zamora, Nelson, Zastrozhin, Mikhail Sergeevich, Zastrozhina, Anasthasia, Zhang, Zhi-Jiang, Zhong, Chenwen, Zmaili, Mohammad, Zumla, Alimuddin, Naghavi, Mohsen, and Schmidt, Maria Inês
- Abstract
Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019.
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- 2022
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31. Organizational Justice and Long-term Metabolic Trajectories: A 25-Year Follow-up of the Whitehall II Cohort
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Varga, Tibor V, Xu, Tianwei, Kivimäki, Mika, Mehta, Amar J, Rugulies, Reiner, and Rod, Naja H
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- 2022
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32. Neighborhood Socioeconomic Disadvantage and Childhood Body Mass Index Trajectories From Birth to 7 Years of Age
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Rautava, Samuli, Turta, Olli, Vahtera, Jussi, Pentti, Jaana, Kivimäki, Mika, Pearce, Jamie, Kawachi, Ichiro, Rautava, Päivi, and Lagström, Hanna
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Supplemental Digital Content is available in the text.
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- 2022
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33. Associations of coffee drinking with physical performance in the oldest-old community-dwelling men The Helsinki Businessmen Study (HBS).
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Jyväkorpi, Satu K., Urtamo, Annele, Kivimäki, Mika, and Strandberg, Timo E.
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Background: Habitual coffee drinking has been associated with lower risk of various chronic diseases linked to poor physical performance. Objective: We explored cross-sectional associations between coffee consumption and physical performance among oldest-old community-dwelling men in the Helsinki Businessmen Study (HBS). Methods: A random sample of HBS survivors (n = 126, mean age 87 years) attended a clinic visit in 2017/2018, including measurements of body composition, physical performance [Short Physical Performance Battery (SPPB)], and cognition. Coffee consumption was retrieved from 3-day food diaries. Results: Coffee consumption was positively associated with higher gait speed (p = 0.003), SPPB score (p = 0.035), and chair rise points (p = 0.043). Association of coffee with gait speed remained after adjustment for age, waist circumference, physical activity, pulse rate, and high-sensitivity C-reactive protein. Conclusion: Higher coffee consumption was independently associated with better physical performance reflected as faster gait speed in oldest-old men. [ABSTRACT FROM AUTHOR]
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- 2021
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34. Subjective Cognitive Complaints Given in Questionnaire: Relationship With Brain Structure, Cognitive Performance and Self-Reported Depressive Symptoms in a 25-Year Retrospective Cohort Study.
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Topiwala, Anya, Suri, Sana, Allan, Charlotte, Zsoldos, Enikő, Filippini, Nicola, Sexton, Claire E., Mahmood, Abda, Singh-Manoux, Archana, Mackay, Clare E., Kivimäki, Mika, and Ebmeier, Klaus P.
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Background: Subjective cognitive complaints are common but it is unclear whether they indicate an underlying pathological process or reflect affective symptoms.Method: 800 community-dwelling older adults were drawn from the Whitehall II cohort. Subjective cognitive complaint inquiry for memory and concentration, a range of neuropsychological tests and multimodal MRI were performed in 2012-2016. Subjective complaints were again elicited after 1 year. Group differences in grey and white matter, between those with and without subjective complaints, were assessed using voxel-based morphometry and tract-based spatial statistics, respectively. Mixed effects models assessed whether cognitive decline or depressive symptoms (over a 25-year period) were associated with later subjective complaints. Analyses were controlled for potential confounders and multiple comparisons.Results: Mean age of the sample at scanning was 69.8 years (±5.1, range: 60.3-84.6). Subjective memory complaints were common (41%) and predicted further similar complaints later (mean 1.4 ± 1.4 years). There were no group differences in grey matter density or white matter integrity. Subjective complaints were not cross-sectionally or longitudinally associated with objectively assessed cognition. However, those with subjective complaints reported higher depressive symptoms ("poor concentration": odds ratio = 1.12, 95% CI 1.07-1.18; "poor memory": odds ratio = 1.18, 1.12-1.24).Conclusions: In our sample subjective complaints were consistent over time and reflected depressive symptoms but not markers of neurodegenerative brain damage or concurrent or future objective cognitive impairment. Clinicians assessing patients presenting with memory complaints should be vigilant for affective disorders. These results question the rationale for including subjective complaints in a spectrum with Mild Cognitive Impairment diagnostic criteria. [ABSTRACT FROM AUTHOR]- Published
- 2021
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35. Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019
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Ward, Joseph L, Azzopardi, Peter S, Francis, Kate Louise, Santelli, John S, Skirbekk, Vegard, Sawyer, Susan M, Kassebaum, Nicholas J, Mokdad, Ali H, Hay, Simon I, Abd-Allah, Foad, Abdoli, Amir, Abdollahi, Mohammad, Abedi, Aidin, Abolhassani, Hassan, Abreu, Lucas Guimarães, Abrigo, Michael R M, Abu-Gharbieh, Eman, Abushouk, Abdelrahman I, Adebayo, Oladimeji M, Adekanmbi, Victor, Adham, Davoud, Advani, Shailesh M, Afshari, Khashayar, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Keivan, Ahmed, Anwar E, Aji, Budi, Akombi-Inyang, Blessing, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alcalde-Rabanal, Jacqueline Elizabeth, Alemu, Biresaw Wassihun, Al-Hajj, Samar, Alhassan, Robert Kaba, Ali, Saqib, Alicandro, Gianfranco, Alijanzadeh, Mehran, Aljunid, Syed Mohamed, Almasi-Hashiani, Amir, Almasri, Nihad A, Al-Mekhlafi, Hesham M, Alonso, Jordi, Al-Raddadi, Rajaa M, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amini, Saeed, Aminorroaya, Arya, Amit, Arianna Maever L, Amugsi, Dickson A, Ancuceanu, Robert, Anderlini, Deanna, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Fereshteh, Ansari, Iman, Antonio, Carl Abelardo T, Anvari, Davood, Anwer, Razique, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-Zozani, Morteza, Ärnlöv, Johan, Asaad, Malke, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A, Atout, Maha Moh'd Wahbi, Ausloos, Marcel, Avenyo, Elvis Korku, Avila-Burgos, Leticia, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Aynalem, Yared Asmare, Azari, Samad, Azene, Zelalem Nigussie, Bakhshaei, Mohammad Hossein, Bakkannavar, Shankar M, Banach, Maciej, Banik, Palash Chandra, Barboza, Miguel A, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Basu, Sanjay, Baune, Bernhard T, Bayati, Mohsen, Bedi, Neeraj, Beghi, Ettore, Bekuma, Tariku Tesfaye, Bell, Arielle Wilder, Bell, Michelle L, Benjet, Corina, Bensenor, Isabela M, Berhe, Abadi Kidanemariam, Berhe, Kidanemaryam, Berman, Adam E, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhattacharyya, Krittika, Bhattarai, Suraj, Bhutta, Zulfiqar A, Bijani, Ali, Bikbov, Boris, Biondi, Antonio, Birhanu, Tesega Tesega Mengistu, Biswas, Raaj Kishore, Bohlouli, Somayeh, Bolla, Srinivasa Rao, Boloor, Archith, Borschmann, Rohan, Boufous, Soufiane, Bragazzi, Nicola Luigi, Braithwaite, Dejana, Breitborde, Nicholas J K, Brenner, Hermann, Britton, Gabrielle B, Burns, Richard A, Burugina Nagaraja, Sharath, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cámera, Luis Alberto, Campos-Nonato, Ismael R, Campuzano Rincon, Julio Cesar, Cárdenas, Rosario, Carreras, Giulia, Carrero, Juan J, Carvalho, Felix, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Catalá-López, Ferrán, Cerin, Ester, Chandan, Joht Singh, Chang, Hsing-Yi, Chang, Jung-Chen, Charan, Jaykaran, Chattu, Vijay Kumar, Chaturvedi, Sarika, Choi, Jee-Young Jasmine, Chowdhury, Mohiuddin Ahsanul Kabir, Christopher, Devasahayam J, Chu, Dinh-Toi, Chung, Michael T, Chung, Sheng-Chia, Cicuttini, Flavia M, Constantin, Traian Vasile, Costa, Vera Marisa, Dahlawi, Saad M A, Dai, Haijiang, Dai, Xiaochen, Damiani, Giovanni, Dandona, Lalit, Dandona, Rakhi, Daneshpajouhnejad, Parnaz, Darwesh, Aso Mohammad, Dávila-Cervantes, Claudio Alberto, Davletov, Kairat, De la Hoz, Fernando Pio, De Leo, Diego, Dervenis, Nikolaos, Desai, Rupak, Desalew, Assefa, Deuba, Keshab, Dharmaratne, Samath Dhamminda, Dhungana, Govinda Prasad, Dianatinasab, Mostafa, Dias da Silva, Diana, Diaz, Daniel, Didarloo, Alireza, Djalalinia, Shirin, Dorostkar, Fariba, Doshi, Chirag P, Doshmangir, Leila, Doyle, Kerrie E, Duraes, Andre Rodrigues, Ebrahimi Kalan, Mohammad, Ebtehaj, Sanam, Edvardsson, David, El Tantawi, Maha, Elgendy, Islam Y, El-Jaafary, Shaimaa I, Elsharkawy, Aisha, Eshrati, Babak, Eskandarieh, Sharareh, Esmaeilnejad, Saman, Esmaeilzadeh, Firooz, Esteghamati, Sadaf, Faro, Andre, Farzadfar, Farshad, Fattahi, Nazir, Feigin, Valery L, Ferede, Tomas Y, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Ferrara, Pietro, Filip, Irina, Fischer, Florian, Fisher, James L, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Foroutan, Masoud, Fukumoto, Takeshi, Gad, Mohamed M, Gaidhane, Abhay Motiramji, Gallus, Silvano, Gebre, Teshome, Gebremedhin, Ketema Bizuwork, Gebremeskel, Gebreamlak Gebremedhn, Gebremeskel, Leake, Gebreslassie, Assefa Ayalew, Gesesew, Hailay Abrha, Ghadiri, Keyghobad, Ghafourifard, Mansour, Ghamari, Farhad, Ghashghaee, Ahmad, Gilani, Syed Amir, Gnedovskaya, Elena V, Godinho, Myron Anthony, Golechha, Mahaveer, Goli, Srinivas, Gona, Philimon N, Gopalani, Sameer Vali, Gorini, Giuseppe, Grivna, Michal, Gubari, Mohammed Ibrahim Mohialdeen, Gugnani, Harish Chander, Guimarães, Rafael Alves, Guo, Yuming, Gupta, Rajeev, Haagsma, Juanita A, Hafezi-Nejad, Nima, Haile, Teklehaimanot Gereziher, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hall, Brian J, Hamadeh, Randah R, Hamagharib Abdullah, Kanaan, Hamidi, Samer, Handiso, Demelash Woldeyohannes, Hanif, Asif, Hankey, Graeme J, Haririan, Hamidreza, Haro, Josep Maria, Hasaballah, Ahmed I, Hashi, Abdiwahab, Hassan, Amr, Hassanipour, Soheil, Hassankhani, Hadi, Hayat, Khezar, Heidari-Soureshjani, Reza, Herteliu, Claudiu, Heydarpour, Fatemeh, Ho, Hung Chak, Hole, Michael K, Holla, Ramesh, Hoogar, Praveen, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hsairi, Mohamed, Huda, Tanvir M, Humayun, Ayesha, Hussain, Rabia, Hwang, Bing-Fang, Iavicoli, Ivo, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Inbaraj, Leeberk Raja, Intarut, Nirun, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Islam, M Mofizul, Islam, Sheikh Mohammed Shariful, Iso, Hiroyasu, Ivers, Rebecca Q, Jahani, Mohammad Ali, Jakovljevic, Mihajlo, Jalali, Amir, Janodia, Manthan Dilipkumar, Javaheri, Tahereh, Jeemon, Panniyammakal, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S, Jonas, Jost B, Jones, Kelly M, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Juliusson, Petur B, Jürisson, Mikk, Kabir, Ali, Kabir, Zubair, Kalankesh, Leila R, Kalhor, Rohollah, Kamyari, Naser, Kanchan, Tanuj, Karch, André, Karimi, Salah Eddin, Kaur, Supreet, Kayode, Gbenga A, Keiyoro, Peter Njenga, Khalid, Nauman, Khammarnia, Mohammad, Khan, Maseer, Khan, Md Nuruzzaman, Khatab, Khaled, Khater, Mona M, Khatib, Mahalaqua Nazli, Khayamzadeh, Maryam, Khazaie, Habibolah, Khoja, Abdullah T, Kieling, Christian, Kim, Young-Eun, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Adnan, Kisa, Sezer, Kivimäki, Mika, Koolivand, Ali, Kosen, Soewarta, Koyanagi, Ai, Krishan, Kewal, Kugbey, Nuworza, Kumar, G Anil, Kumar, Manasi, Kumar, Nithin, Kurmi, Om P, Kusuma, Dian, La Vecchia, Carlo, Lacey, Ben, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lan, Qing, Landires, Iván, Lansingh, Van Charles, Larsson, Anders O, Lasrado, Savita, Lassi, Zohra S, Lauriola, Paolo, Lee, Paul H, Lee, Shaun Wen Huey, Leigh, James, Leonardi, Matilde, Leung, Janni, Levi, Miriam, Lewycka, Sonia, Li, Bingyu, Li, Ming-Chieh, Li, Shanshan, Lim, Lee-Ling, Lim, Stephen S, Liu, Xuefeng, Lorkowski, Stefan, Lotufo, Paulo A, Lunevicius, Raimundas, Maddison, Ralph, Mahasha, Phetole Walter, Mahdavi, Mokhtar Mahdavi, Mahmoudi, Morteza, Majeed, Azeem, Maleki, Afshin, Malekzadeh, Reza, Malta, Deborah Carvalho, Mamun, Abdullah A, Mansouri, Borhan, Mansournia, Mohammad Ali, Martinez, Gabriel, Martinez-Raga, Jose, Martins-Melo, Francisco Rogerlândio, Mason-Jones, Amanda J, Masoumi, Seyedeh Zahra, Mathur, Manu Raj, Maulik, Pallab K, McGrath, John J, Mehndiratta, Man Mohan, Mehri, Fereshteh, Memiah, Peter T N, Mendoza, Walter, Menezes, Ritesh G, Mengesha, Endalkachew Worku, Meretoja, Atte, Meretoja, Tuomo J, Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Michalek, Irmina Maria, Miller, Ted R, Mini, GK, Mirica, Andreea, Mirrakhimov, Erkin M, Mirzaei, Hamed, Mirzaei, Maryam, Moazen, Babak, Mohammad, Dara K, Mohammadi, Shadieh, Mohammadian-Hafshejani, 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Mohammad sadegh, Riahi, Seyed Mohammad, Rickard, Jennifer, Roever, Leonardo, Ronfani, Luca, Roth, Gregory A, Rubagotti, Enrico, Rumisha, Susan Fred, Rwegerera, Godfrey M, Sabour, Siamak, Sachdev, Perminder S, Saddik, Basema, Sadeghi, Ehsan, Saeedi Moghaddam, Sahar, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sajadi, S Mohammad, Salem, Marwa Rashad, Salimzadeh, Hamideh, Samy, Abdallah M, Sanabria, Juan, Santric-Milicevic, Milena M, Saraswathy, Sivan Yegnanarayana Iyer, Sarrafzadegan, Nizal, Sarveazad, Arash, Sathish, Thirunavukkarasu, Sattin, Davide, Saxena, Deepak, Saxena, Sonia, Schiavolin, Silvia, Schwebel, David C, Schwendicke, Falk, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Sha, Feng, Shafaat, Omid, Shahabi, Saeed, Shaheen, Amira A, Shaikh, Masood Ali, Shakiba, Saeed, Shamsi, MohammadBagher, Shannawaz, Mohammed, Sharafi, Kiomars, Sheikh, Aziz, Sheikhbahaei, Sara, Shetty, B Suresh Kumar, Shi, Peilin, Shigematsu, Mika, Shin, Jae Il, Shiri, Rahman, Shuval, Kerem, Siabani, Soraya, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silva, Diego Augusto Santos, Silva, João Pedro, Simonetti, Biagio, Singh, Jasvinder A, Singh, Virendra, Sinke, Abiy H, Skryabin, Valentin Yurievich, Slater, Helen, Smith, Emma U R, Sobhiyeh, Mohammad Reza, Sobngwi, Eugene, Soheili, Amin, Somefun, Oluwaseyi Dolapo, Sorrie, Muluken Bekele, Soyiri, Ireneous N, Sreeramareddy, Chandrashekhar T, Stein, Dan J, Stokes, Mark A, Sudaryanto, Agus, Sultan, Iyad, Tabarés-Seisdedos, Rafael, Tabuchi, Takahiro, Tadakamadla, Santosh Kumar, Taherkhani, Amir, Tamiru, Animut Tagele, Tareque, Md Ismail, Thankappan, Kavumpurathu Raman, Thapar, Rekha, Thomas, Nihal, Titova, Mariya Vladimirovna, Tonelli, Marcello, Tovani-Palone, Marcos Roberto, Tran, Bach Xuan, Travillian, Ravensara S, Tsai, Alexander C, Tsatsakis, Aristidis, Tudor Car, Lorainne, Uddin, Riaz, Unim, Brigid, Unnikrishnan, Bhaskaran, Upadhyay, Era, Vacante, Marco, Valadan Tahbaz, Sahel, Valdez, Pascual R, Varughese, Santosh, Vasankari, Tommi Juhani, Venketasubramanian, Narayanaswamy, Villeneuve, Paul J, Violante, Francesco S, Vlassov, Vasily, Vos, Theo, Vu, Giang Thu, Waheed, Yasir, Wamai, Richard G, Wang, Yafeng, Wang, Yanzhong, Wang, Yuan-Pang, Westerman, Ronny, Wickramasinghe, Nuwan Darshana, Wu, Ai-Min, Wu, Chenkai, Yahyazadeh Jabbari, Seyed Hossein, Yamagishi, Kazumasa, Yano, Yuichiro, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Yeshitila, Yordanos Gizachew, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Yousefinezhadi, Taraneh, Yu, Chuanhua, Yu, Yong, Yuce, Deniz, Zaidi, Syed Saoud, Zaman, Sojib Bin, Zamani, Mohammad, Zamanian, Maryam, Zarafshan, Hadi, Zarei, Ahmad, Zastrozhin, Mikhail Sergeevich, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhao, Xiu-Ju George, Zhu, Cong, Patton, George C, and Viner, Russell M
- Abstract
Documentation of patterns and long-term trends in mortality in young people, which reflect huge changes in demographic and social determinants of adolescent health, enables identification of global investment priorities for this age group. We aimed to analyse data on the number of deaths, years of life lost, and mortality rates by sex and age group in people aged 10–24 years in 204 countries and territories from 1950 to 2019 by use of estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019.
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- 2021
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36. Associations of sleep quality, quantity and nutrition in oldest-old men The Helsinki Businessmen Study (HBS).
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Jyväkorpi, Satu K., Urtamo, Annele, Kivimäki, Mika, and Strandberg, Timo E.
- Abstract
Key summary points: Aim: To investigate associations of sleep quality and quantity and nutrition in oldest-old men. Findings: Sleep quality was associated with nutritional status and vegetable intakes, whereas sleep quantity was linked to fish intake. Message: Healthy nutrition may be an important contributor of sleep hygiene in oldest-old men. Introduction: Sleep quality and quantity often decline as people age, which may negatively impact health. We examined how nutrition is associated with self-reported sleep quality and quantity in oldest-old community-dwelling men. Methods: In this cross-sectional analysis of the Helsinki Businessmen Study (HBS), a random sample of 130 surviving participants underwent a clinical examination in 2017–2018. Food and nutrient intakes were retrieved from 3-day food diaries in 126 men, and sleep quality and quantity were determined with a questionnaire. Nutritional status was assessed using Mini Nutritional Assessment Short Form (MNA-SF), General Health and Vitality were measured with RAND-36/SF-36 health-related quality of life instrument, and albumin and creatinine levels were analyzed from fasting serum samples. Results: Mean age of the survivors was 87 years (range 83–99). Self-reported sleep quality and quantity were highly correlated (p < 0.001, η
2 = 0.693). Nutritional status (MNA-SF) (p = 0.006, η2 = 0.076), vegetable intake (p = 0.030. η2 = 0.041) and vitality (p = 0.008, η2 = 0.101) were associated with better sleep quality and fish (p = 0.028, η2 = 0.051) intake was associated with longer sleep duration. This association remained after adjusting for age, sleep quality, carbohydrate energy %, and albumin levels. Conclusion: Healthy nutrition may be an important contributor to sleep hygiene in oldest-old men. [ABSTRACT FROM AUTHOR]- Published
- 2021
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37. Soft X‑ray Induced Production of Neutral Fragments in High-Rydberg States at the O 1s Ionization Threshold of the Water Molecule.
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Kivimäki, Antti, Wasowicz, Tomasz J., and Richter, Robert
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- 2021
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38. Long‐term risk of dementia following hospitalization due to physical diseases: A multicohort study.
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Sipilä, Pyry N, Lindbohm, Joni V, Singh‐Manoux, Archana, Shipley, Martin J., Kiiskinen, Tuomo, Havulinna, Aki S, Vahtera, Jussi, Nyberg, Solja T, Pentti, Jaana, and Kivimäki, Mika
- Abstract
Introduction: Conventional risk factors targeted by prevention (e.g., low education, smoking, and obesity) are associated with a 1.2‐ to 2‐fold increased risk of dementia. It is unclear whether having a physical disease is an equally important risk factor for dementia. Methods: In this exploratory multicohort study of 283,414 community‐dwelling participants, we examined 22 common hospital‐treated physical diseases as risk factors for dementia. Results: During a median follow‐up of 19 years, a total of 3416 participants developed dementia. Those who had erysipelas (hazard ratio = 1.82; 95% confidence interval = 1.53 to 2.17), hypothyroidism (1.94; 1.59 to 2.38), myocardial infarction (1.41; 1.20 to 1.64), ischemic heart disease (1.32; 1.18 to 1.49), cerebral infarction (2.44; 2.14 to 2.77), duodenal ulcers (1.88; 1.42 to 2.49), gastritis and duodenitis (1.82; 1.46 to 2.27), or osteoporosis (2.38; 1.75 to 3.23) were at a significantly increased risk of dementia. These associations were not explained by conventional risk factors or reverse causation. Discussion: In addition to conventional risk factors, several physical diseases may increase the long‐term risk of dementia. [ABSTRACT FROM AUTHOR]
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- 2020
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39. Association between change in cardiovascular risk scores and future cardiovascular disease: analyses of data from the Whitehall II longitudinal, prospective cohort study
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Lindbohm, Joni V, Sipilä, Pyry N, Mars, Nina, Knüppel, Anika, Pentti, Jaana, Nyberg, Solja T, Frank, Philipp, Ahmadi-Abhari, Sara, Brunner, Eric J, Shipley, Martin J, Singh-Manoux, Archana, Tabak, Adam G, Batty, G David, and Kivimäki, Mika
- Abstract
Evaluation of cardiovascular disease risk in primary care, which is recommended every 5 years in middle-aged and older adults (typical age range 40–75 years), is based on risk scores, such as the European Society of Cardiology Systematic Coronary Risk Evaluation (SCORE) and American College of Cardiology/American Heart Association Atherosclerotic Cardiovascular Disease (ASCVD) algorithms. This evaluation currently uses only the most recent risk factor assessment. We aimed to examine whether 5-year changes in SCORE and ASCVD risk scores are associated with future cardiovascular disease risk.
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- 2021
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40. Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019
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Reitsma, Marissa B, Kendrick, Parkes J, Ababneh, Emad, Abbafati, Cristiana, Abbasi-Kangevari, Mohsen, Abdoli, Amir, Abedi, Aidin, Abhilash, E S, Abila, Derrick Bary, Aboyans, Victor, Abu-Rmeileh, Niveen ME, Adebayo, Oladimeji M, Advani, Shailesh M, Aghaali, Mohammad, Ahinkorah, Bright Opoku, Ahmad, Sohail, Ahmadi, Keivan, Ahmed, Haroon, Aji, Budi, Akunna, Chisom Joyqueenet, Al-Aly, Ziyad, Alanzi, Turki M, Alhabib, Khalid F, Ali, Liaqat, Alif, Sheikh Mohammad, Alipour, Vahid, Aljunid, Syed Mohamed, Alla, François, Allebeck, Peter, Alvis-Guzman, Nelson, Amin, Tarek Tawfik, Amini, Saeed, Amu, Hubert, Amul, Gianna Gayle Herrera, Ancuceanu, Robert, Anderson, Jason A, Ansari-Moghaddam, Alireza, Antonio, Carl Abelardo T, Antony, Benny, Anvari, Davood, Arabloo, Jalal, Arian, Nicholas D, Arora, Monika, Asaad, Malke, Ausloos, Marcel, Awan, Asma Tahir, Ayano, Getinet, Aynalem, Getie Lake, Azari, Samad, B, Darshan B, Badiye, Ashish D, Baig, Atif Amin, Bakhshaei, Mohammad Hossein, Banach, Maciej, Banik, Palash Chandra, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barqawi, Hiba Jawdat, Basu, Sanjay, Bayati, Mohsen, Bazargan-Hejazi, Shahrzad, Behzadifar, Masoud, Bekuma, Tariku Tesfaye, Bennett, Derrick A, Bensenor, Isabela M, Berfield, Kathleen S Sachiko, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhattacharyya, Krittika, Bibi, Sadia, Bijani, Ali, Bintoro, Bagas Suryo, Biondi, Antonio, Birara, Setognal, Braithwaite, Dejana, Brenner, Hermann, Brunoni, Andre R, Burkart, Katrin, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cámera, Luis Alberto, Car, Josip, Cárdenas, Rosario, Carreras, Giulia, Carrero, Juan J, Castaldelli-Maia, Joao Mauricio, Cattaruzza, Maria Sofia Sofia, Chang, Jung-Chen, Chen, Simiao, Chu, Dinh-Toi, Chung, Sheng-Chia, Cirillo, Massimo, Costa, Vera Marisa, Couto, Rosa A S, Dadras, Omid, Dai, Xiaochen, Damasceno, Albertino Antonio Moura, Damiani, Giovanni, Dandona, Lalit, Dandona, Rakhi, Daneshpajouhnejad, Parnaz, Darega Gela, Jiregna, Davletov, Kairat, Derbew Molla, Meseret, Dessie, Getenet Ayalew, Desta, Abebaw Alemayehu, Dharmaratne, Samath Dhamminda, Dianatinasab, Mostafa, Diaz, Daniel, Do, Hoa Thi, Douiri, Abdel, Duncan, Bruce B, Duraes, Andre Rodrigues, Eagan, Arielle Wilder, Ebrahimi Kalan, Mohammad, Edvardsson, Kristina, Elbarazi, Iffat, El Tantawi, Maha, Esmaeilnejad, Saman, Fadhil, Ibtihal, Faraon, Emerito Jose A, Farinha, Carla Sofia e Sá, Farwati, Medhat, Farzadfar, Farshad, Fazlzadeh, Mehdi, Feigin, Valery L, Feldman, Rachel, Fernandez Prendes, Carlota, Ferrara, Pietro, Filip, Irina, Filippidis, Filippos, Fischer, Florian, Flor, Luisa Sorio, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Foroutan, Masoud, Gad, Mohamed M, Gaidhane, Abhay Motiramji, Gallus, Silvano, Geberemariyam, Biniyam Sahiledengle, Ghafourifard, Mansour, Ghajar, Alireza, Ghashghaee, Ahmad, Giampaoli, Simona, Gill, Paramjit Singh, Glozah, Franklin N, Gnedovskaya, Elena V, Golechha, Mahaveer, Gopalani, Sameer Vali, Gorini, Giuseppe, Goudarzi, Houman, Goulart, Alessandra C, Greaves, Felix, Guha, Avirup, Guo, Yuming, Gupta, Bhawna, Gupta, Rajat Das, Gupta, Rajeev, Gupta, Tarun, Gupta, Vin, Hafezi-Nejad, Nima, Haider, Mohammad Rifat, Hamadeh, Randah R, Hankey, Graeme J, Hargono, Arief, Hartono, Risky Kusuma, Hassankhani, Hadi, Hay, Simon I, Heidari, Golnaz, Herteliu, Claudiu, Hezam, Kamal, Hird, Thomas R, Hole, Michael K, Holla, Ramesh, Hosseinzadeh, Mehdi, Hostiuc, Sorin, Househ, Mowafa, Hsiao, Thomas, Huang, Junjie, Iannucci, Vincent C, Ibitoye, Segun Emmanuel, Idrisov, Bulat, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Inbaraj, Leeberk Raja, Irvani, Seyed Sina Naghibi, Islam, Jessica Y, Islam, Rakibul M, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Iso, Hiroyasu, Itumalla, Ramaiah, Iwagami, Masao, Jaafari, Jalil, Jain, Vardhmaan, Jakovljevic, Mihajlo, Jang, Sung-In, Janjani, Hosna, Jayaram, Shubha, Jeemon, Panniyammakal, Jha, Ravi Prakash, Jonas, Jost B, Joo, Tamas, Jürisson, Mikk, Kabir, Ali, Kabir, Zubair, Kalankesh, Leila R, Kanchan, Tanuj, Kandel, Himal, Kapoor, Neeti, Karimi, Salah Eddin, Katikireddi, Srinivasa Vittal, Kebede, Hafte Kahsay, Kelkay, Bayew, Kennedy, Ryan David, Khoja, Abdullah T, Khubchandani, Jagdish, Kim, Gyu Ri, Kim, Young-Eun, Kimokoti, Ruth W, Kivimäki, Mika, Kosen, Soewarta, Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Krishan, Kewal, Kugbey, Nuworza, Kumar, G Anil, Kumar, Nithin, Kurmi, Om P, Kusuma, Dian, Lacey, Ben, Lam, Jennifer O, Landires, Iván, Lasrado, Savita, Lauriola, Paolo, Lee, Doo Woong, Lee, Yo Han, Leung, Janni, Li, Shanshan, Lin, Hualiang, Linn, Shai, Liu, Wei, Lopez, Alan D, Lopukhov, Platon D, Lorkowski, Stefan, Lugo, Alessandra, Majeed, Azeem, Maleki, Afshin, Malekzadeh, Reza, Malta, Deborah Carvalho, Mamun, Abdullah A, Manjunatha, Narayana, Mansouri, Borhan, Mansournia, Mohammad Ali, Martinez-Raga, Jose, Martini, Santi, Mathur, Manu Raj, Medina-Solís, Carlo Eduardo, Mehata, Suresh, Mendoza, Walter, 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Andrew T, Oren, Eyal, Otstavnov, Nikita, Otstavnov, Stanislav S, Owolabi, Mayowa O, P A, Mahesh, Pakhale, Smita, Pakshir, Keyvan, Palladino, Raffaele, Pana, Adrian, Panda-Jonas, Songhomitra, Pandey, Ashok, Parekh, Utsav, Park, Eun-Cheol, Park, Eun-Kee, Pashazadeh Kan, Fatemeh, Patton, George C, Pawar, Shrikant, Pestell, Richard G, Pinheiro, Marina, Piradov, Michael A, Pirouzpanah, Saeed, Pokhrel, Khem Narayan, Polibin, Roman V, Prashant, Akila, Pribadi, Dimas Ria Angga, Radfar, Amir, Rahimi-Movaghar, Vafa, Rahman, Azizur, Rahman, Mohammad Hifz Ur, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rajai, Nazanin, Ram, Pradhum, Ranabhat, Chhabi Lal, Rathi, Priya, Rawal, Lal, Renzaho, Andre M N, Reynales-Shigematsu, Luz Myriam, Rezapour, Aziz, Riahi, Seyed Mohammad, Riaz, Mavra A, Roever, Leonardo, Ronfani, Luca, Roshandel, Gholamreza, Roy, Ambuj, Roy, Bedanta, Sacco, Simona, Saddik, Basema, Sahebkar, Amirhossein, Salehi, Sana, Salimzadeh, Hamideh, Samaei, Mehrnoosh, Samy, Abdallah M, Santos, Itamar S, Santric-Milicevic, Milena M, Sarrafzadegan, Nizal, Sathian, Brijesh, Sawhney, Monika, Saylan, Mete, Schaub, Michael P, Schmidt, Maria Inês, Schneider, Ione Jayce Ceola, Schutte, Aletta Elisabeth, Schwendicke, Falk, Seidu, Abdul-Aziz, Senthil Kumar, Nachimuthu, Sepanlou, Sadaf G, Seylani, Allen, Shafaat, Omid, Shah, Syed Mahboob, Shaikh, Masood Ali, Shalash, Ali S, Shannawaz, Mohammed, Sharafi, Kiomars, Sheikh, Aziz, Sheikhbahaei, Sara, Shigematsu, Mika, Shiri, Rahman, Shishani, Kawkab, Shivakumar, K M, Shivalli, Siddharudha, Shrestha, Roman, Siabani, Soraya, Sidemo, Negussie Boti, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silva, Diego Augusto Santos, Silva, João Pedro, Singh, Ambrish, Singh, Jasvinder A, Singh, Virendra, Sinha, Dhirendra Narain, Sitas, Freddy, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Soboka, Matiwos, Soriano, Joan B, Soroush, Ali, Soshnikov, Sergey, Soyiri, Ireneous N, Spurlock, Emma Elizabeth, Sreeramareddy, Chandrashekhar T, Stein, Dan J, Steiropoulos, Paschalis, Stortecky, Stefan, Straif, Kurt, Suliankatchi Abdulkader, Rizwan, Sulo, Gerhard, Sundström, Johan, Tabuchi, Takahiro, Tadakamadla, Santosh Kumar, Taddele, Biruk Wogayehu, Tadesse, Eyayou Girma, Tamiru, Animut Tagele, Tareke, Minale, Tareque, Md Ismail, Tarigan, Ingan Ukur, Temsah, Mohamad-Hani, Thankappan, Kavumpurathu Raman, Thapar, Rekha, Tichopad, Ales, Tolani, Musliu Adetola, Topouzis, Fotis, Tovani-Palone, Marcos Roberto, Tran, Bach Xuan, Tripathy, Jaya Prasad, Tsegaye, Gebiyaw Wudie, Tsilimparis, Nikolaos, Tymeson, Hayley D, Ullah, Anayat, Ullah, Saif, Unim, Brigid, Updike, Rachel L, Vacante, Marco, Valdez, Pascual R, Vardavas, Constantine, Varona Pérez, Patricia, Vasankari, Tommi Juhani, Venketasubramanian, Narayanaswamy, Verma, Madhur, Vetrova, Marina V, Vo, Bay, Vu, Giang Thu, Waheed, Yasir, Wang, Yanzhong, Welding, Kevin, Werdecker, Andrea, Whisnant, Joanna L, Wickramasinghe, Nuwan Darshana, Yamagishi, Kazumasa, Yandrapalli, Srikanth, Yatsuya, Hiroshi, Yazdi-Feyzabadi, Vahid, Yeshaw, Yigizie, Yimmer, Mohammed Zewdu, Yonemoto, Naohiro, Yu, Chuanhua, Yunusa, Ismaeel, Yusefzadeh, Hasan, Zahirian Moghadam, Telma, Zaman, Muhammed Shahriar, Zamanian, Maryam, Zandian, Hamed, Zar, Heather J, Zastrozhin, Mikhail Sergeevich, Zastrozhina, Anasthasia, Zavala-Arciniega, Luis, Zhang, Jianrong, Zhang, Zhi-Jiang, Zhong, Chenwen, Zuniga, Yves Miel H, and Gakidou, Emmanuela
- Abstract
Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally.
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- 2021
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41. Core and Valence Level Photoelectron Spectroscopy of Nanosolvated KCl
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Pelimanni, Eetu, Hautala, Lauri, Hans, Andreas, Kivimäki, Antti, Kook, Mati, Küstner-Wetekam, Catmarna, Marder, Lutz, Patanen, Minna, and Huttula, Marko
- Abstract
The solvation of alkali and halide ions in the aqueous environment has been a subject of intense experimental and theoretical research with multidisciplinary interests; yet, a comprehensive molecular-level understanding has still not been obtained. In recent years, electron spectroscopy has been increasingly applied to study the electronic and structural properties of aqueous ions with implications, especially in atmospheric chemistry. In this work, we report core and valence level (Cl 2p, Cl 3p, and K 3p) photoelectron spectra of the common alkali halide, KCl, doped in gas-phase water clusters in the size range of a few hundred water molecules. The results indicate that the electronic structure of these nanosolutions shows a distinct character from that observed at the liquid–vapor interface in liquid microjets and ambient pressure setups. Insights are provided into the unique solvation properties of ions in a nanoaqueous environment, emerging properties of bulk electrolyte solutions with growing cluster size, and sensitivity of the electronic structure to varying solvation configurations.
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- 2021
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42. Leisure activity participation and risk of dementia: An 18-year follow-up of the Whitehall II Study.
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Sommerlad, Andrew, Sabia, Séverine, Livingston, Gill, Kivimäki, Mika, Lewis, Glyn, and Singh-Manoux, Archana
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- 2020
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43. Associations of protein source, distribution and healthy dietary pattern with appendicular lean mass in oldest-old men: the Helsinki Businessmen Study (HBS).
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Jyväkorpi, S. K., Urtamo, A., Kivimäki, M., and Strandberg, T. E.
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Key summary points: Aim: To investigate how food and dietary intakes, protein daily distribution and source were associated with appendicular lean mass (ALM)/m
2 in the oldest-old community-dwelling men. Findings: ALM/m2 was associated with total protein intake, source and distribution as well as fruit and vegetable intakes. Message: Not only protein intake, but also source and distribution as well as healthy overall diet characterized by abundant amounts of fruits and vegetables were important in maintaining muscle mass in the oldest-old men in our study. Purpose: We explored how food and dietary intakes, protein daily distribution and source are associated with appendicular lean mass (ALM)/m2 of the oldest-old community-dwelling men. Methods: Cross-sectional analyses of Helsinki Businessmen Study (HBS, mean age 87 years) participants who came to clinic visit in 2017/2018. Nutritional status, physical performance and fasting blood samples were measured. Food and dietary intakes were retrieved from 3-day food diaries. Body composition was measured and appendicular lean mass (ALM) per m2 was dichotomized as ALM/m2 < 7 kg/m2 and ≥ 7 kg/m2 . Differences between lower and higher ALM were analyzed using t test or Mann–Whitney U test. Analysis of covariance was used to investigate independent associations with ALM/m2 . Results: Random sample of 130 participants took part in the medical examinations, 126 returned food diaries, and 102 underwent DXA-scan. ALM/m2 was associated with total protein (p = 0.033), animal protein (p = 0.043) and meat protein (p = 0.033) intakes. Protein distribution between daily meals differed at lunch; those with higher ALM/m2 ate more protein (p =.047) at lunch. Consumption of fruits, vegetables (p = 0.022) and meat (p = 0.006) was associated with ALM/m2 . Conclusion: Protein intake, source and distribution as well fruit and vegetable intakes were associated with higher ALM in oldest-old men. Study registration: The study is registered with ClinicalTrials.gov identifier: NCT02526082. [ABSTRACT FROM AUTHOR]- Published
- 2020
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44. Associations of overweight and metabolic health with successful aging: 32-year follow-up of the Helsinki Businessmen Study.
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Jyväkorpi, Satu K., Urtamo, Annele, Strandberg, Arto Y., von Bonsdorff, Mikaela, Salomaa, Veikko, Kivimäki, Mika, Luotola, Kari, and Strandberg, Timo E.
- Abstract
Prognostic significance of metabolically healthy overweight and obesity (MHO) is under debate. However the relationship between MHO and health-related quality of life (HRQoL) is less studied. We compared successful aging (longevity plus HRQoL) in men with MHO, metabolically healthy normal weight (MHN) and metabolically unhealthy overweight and obesity (MUO). In the Helsinki Businessmen Study longitudinal cohort, consisting of men born 1919 to 1934. In 1985/86, overweight (BMI≥25 kg/m
2 ) and metabolic health were determined in 1309 men (median age 60 years). HRQoL was assessed using RAND-36/SF-36 in 2000 and 2007, and all-cause mortality retrieved from registers up to 2018. The proportion of men reaching 90 years was also calculated. Of the men, 469 (35.8%), 538 (41.1%), 276 (21.1%), and 26 (2.0%) were MHN, MHO, MUO and MUN, respectively. During the 32-year follow-up, 72.3% men died. With MHN as reference, adjusted hazard ratio with all-cause mortality was 1.08 (95% confidence interval [CI] 0.93 to 1.27) for MHO, and 1.18 (95% CI 0.95 to 1.47) for MUO. During follow-up, 273 men reached 90 years. With MHN as reference, adjusted odds ratio for MHO was 0.82 (95% CI 0.59 to 1.14) and 0.62 (95% CI 0.41 to 0.95) for MUO. Men in MHN group scored generally highest in RAND-36 HRQoL subscales in 2000 and 2007, of those significantly better in Physical functioning, Role physical, Role emotional, Bodily Pain, and General health sub-scales compared to MHO group in 2000. As compared to MHN, MHO in late midlife does not increase mortality, but impairs odds for successful aging. • Metabolically unhealthy obesity (MHO) in late midlife did not increase mortality in this study. • MHO impaired odds for successful aging defined as longevity and Health Related Quality of Life. • Those with metabolically healthy normal weight (MHN) at baseline had better quality of life at old age than those with MHO. • Men with MHN had higher odds of reaching 90 years than those men with MHO or MUO at baseline. [ABSTRACT FROM AUTHOR]- Published
- 2020
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45. Associations of coffee drinking with physical performance in the oldest-old community-dwelling men The Helsinki Businessmen Study (HBS)
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Jyväkorpi, Satu K., Urtamo, Annele, Kivimäki, Mika, and Strandberg, Timo E.
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Background: Habitual coffee drinking has been associated with lower risk of various chronic diseases linked to poor physical performance. Objective: We explored cross-sectional associations between coffee consumption and physical performance among oldest-old community-dwelling men in the Helsinki Businessmen Study (HBS). Methods: A random sample of HBS survivors (n= 126, mean age 87 years) attended a clinic visit in 2017/2018, including measurements of body composition, physical performance [Short Physical Performance Battery (SPPB)], and cognition. Coffee consumption was retrieved from 3-day food diaries. Results: Coffee consumption was positively associated with higher gait speed (p= 0.003), SPPB score (p= 0.035), and chair rise points (p= 0.043). Association of coffee with gait speed remained after adjustment for age, waist circumference, physical activity, pulse rate, and high-sensitivity C-reactive protein. Conclusion: Higher coffee consumption was independently associated with better physical performance reflected as faster gait speed in oldest-old men.
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- 2021
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46. Subjective Cognitive Complaints Given in Questionnaire: Relationship With Brain Structure, Cognitive Performance and Self-Reported Depressive Symptoms in a 25-Year Retrospective Cohort Study
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Topiwala, Anya, Suri, Sana, Allan, Charlotte, Zsoldos, Enikő, Filippini, Nicola, Sexton, Claire E., Mahmood, Abda, Singh-Manoux, Archana, Mackay, Clare E., Kivimäki, Mika, and Ebmeier, Klaus P.
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What is the primary question addressed by this study?• Subjective cognitive complaints are common but it is unclear whether they indicate an underlying pathological process or reflect affective symptoms.What is the main finding of this study?• This study found no relation between subjective complaints and objective cross-sectional or longitudinal cognitive deficits or neuroimaging markers.• Subjective cognitive complaints were however associated with self-reported depressive symptoms.What is the meaning of the finding?• Psychiatrists should be vigilant for affective disorders in those presenting complaining of poor memory.
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- 2021
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47. Soft X-ray Induced Production of Neutral Fragments in High-Rydberg States at the O 1s Ionization Threshold of the Water Molecule
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Kivimäki, Antti, Wasowicz, Tomasz J., and Richter, Robert
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Dissociation of water molecules after soft X-ray absorption can yield neutral fragments in high-Rydberg (HR) states. We have studied the production of such fragments by field ionization and ion time-of-flight (TOF) spectrometry. Neutral HR fragments are created at all resonances below the O 1s ionization potential (IP) and particularly within 1 eV above the O 1s IP. The latter effect is due to the recapture of the O 1s photoelectrons into HR orbitals of the molecular water ion after the emission of a fast Auger electron. H2O+(HR) fragments subsequently dissociate, yielding neutral H(HR) and O(HR) fragments, as were found by measuring the TOF spectra by pulsed field ionization. Such measurements were carried out at the O 1s → 4a1and 2b2resonances as well as just above the O 1s IP. The TOF spectra also reveal two series of oscillatory structures that are attributed to quantum beats involving Lyman emission in one of the series and field ionization of H(HR) fragments in the other series.
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- 2021
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48. Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory
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Brunner, Eric J., Maruyama, Koutatsu, Shipley, Martin, Cable, Noriko, Iso, Hiroyasu, Hiyoshi, Ayako, Stallone, Daryth, Kumari, Meena, Tabak, Adam, Singh-Manoux, Archana, Wilson, John, Langenberg, Claudia, Wareham, Nick, Boniface, David, Hingorani, Aroon, Kivimäki, Mika, and Llewellyn, Clare
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Background/objectives: The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of genetic susceptibility and appetite to weight gain. Subjects/methods: We followed the body-mass index (BMI) trajectories of 2464 adults from 45 to 65 years of age by measuring weight and height on four occasions at 5-year intervals. Genetic risk of obesity (gene risk score: GRS) was ascertained, comprising 92 BMI-associated single-nucleotide polymorphisms and split at a median (=high and low risk). At the baseline, the Eating Inventory was used to assess appetite-related traits of ‘disinhibition’, indicative of opportunistic eating or overeating and ‘hunger’ which is susceptibility to/ability to cope with the sensation of hunger. Roles of the GRS and two appetite-related scores for BMI trajectories were examined using a mixed model adjusted for the cohort effect and sex. Results: Disinhibition was associated with higher BMI (β= 2.96; 95% CI: 2.66–3.25 kg/m
2 ), and accounted for 34% of the genetically-linked BMI difference at age 45. Hunger was also associated with higher BMI (β= 1.20; 0.82–1.59 kg/m2 ) during mid-life and slightly steeper weight gain, but did not attenuate the effect of disinhibition. Conclusions: Appetite disinhibition is most likely to be a defining characteristic of genetic susceptibility to obesity. High levels of appetite disinhibition, rather than hunger, may underlie genetic vulnerability to obesogenic environments in two-thirds of the population of European ancestry.- Published
- 2021
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49. Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019
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Wang, Haidong, Abbas, Kaja M, Abbasifard, Mitra, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd-Allah, Foad, Abdelalim, Ahmed, Abolhassani, Hassan, Abreu, Lucas Guimarães, Abrigo, Michael R M, Abushouk, Abdelrahman I, Adabi, Maryam, Adair, Tim, Adebayo, Oladimeji M, Adedeji, Isaac Akinkunmi, Adekanmbi, Victor, Adeoye, Abiodun Moshood, Adetokunboh, Olatunji O, Advani, Shailesh M, Afshin, Ashkan, Aghaali, Mohammad, Agrawal, Anurag, Ahmadi, Keivan, Ahmadieh, Hamid, Ahmed, Muktar Beshir, Al-Aly, Ziyad, Alam, Khurshid, Alam, Tahiya, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alcalde-Rabanal, Jacqueline Elizabeth, Ali, Muhammad, Alicandro, Gianfranco, Alijanzadeh, Mehran, Alinia, Cyrus, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Allebeck, Peter, Almadi, Majid Abdulrahman Hamad, Almasi-Hashiani, Amir, Al-Mekhlafi, Hesham M, Altirkawi, Khalid A, Alumran, Arwa Khalid, Alvis-Guzman, Nelson, Amini-Rarani, Mostafa, Aminorroaya, Arya, Amit, Arianna Maever L, Ancuceanu, Robert, Andrei, Catalina Liliana, Androudi, Sofia, Angus, Colin, Anjomshoa, Mina, Ansari, Fereshteh, Ansari, Iman, Ansari-Moghaddam, Alireza, Antonio, Carl Abelardo T, Antony, Catherine M, Anvari, Davood, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-Zozani, Morteza, Aravkin, Aleksandr Y, Aremu, Olatunde, Ärnlöv, Johan, Aryal, Krishna K, Asadi-Pooya, Ali A, Asgari, Samaneh, Asghari Jafarabadi, Mohammad, Atteraya, Madhu Sudhan, Ausloos, Marcel, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel Gbenato Arthur, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Azarian, Ghasem, Babaee, Ebrahim, Badiye, Ashish D, Bagli, Eleni, Bahrami, Mohammad Amin, Bakhtiari, Ahad, Balassyano, Shelly, Banach, Maciej, Banik, Palash Chandra, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barzegar, Akbar, Basu, Sanjay, Baune, Bernhard T, Bayati, Mohsen, Bazmandegan, Gholamreza, Bedi, Neeraj, Bell, Michellr L, Bennett, Derrick A, Bensenor, Isabela M, Berhe, Kidanemaryam, Berman, Adam E, Bertolacci, Gregory J, Bhageerathy, Reshmi, Bhala, Neeraj, Bhattacharyya, Krittika, Bhutta, Zulfiqar A, Bijani, Ali, Biondi, Antonio, Bisanzio, Donal, Bisignano, Catherine, Biswas, Raaj Kishore, Bjørge, Tone, Bohlouli, Somayeh, Bohluli, Mehdi, Bolla, Srinivasa Rao Rao, Borzì, Antonio Maria, Borzouei, Shiva, Brady, Oliver J, Braithwaite, Dejana, Brauer, Michael, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Bumgarner, Blair R, Burugina Nagaraja, Sharath, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cai, Tianji, Callender, Charlton SKH, Cámera, Luis LA Alberto, Campos-Nonato, Ismael R, Cárdenas, Rosario, Carreras, Giulia, Carrero, Juan J, Carvalho, Felix, Castaldelli-Maia, Joao Mauricio, Castelpietra, Giulio, Castro, Franz, Catalá-López, Ferrán, Cederroth, Christopher R, Cerin, Ester, Chattu, Vijay Kumar, Chin, Ken Lee, Chu, Dinh-Toi, Ciobanu, Liliana G, Cirillo, Massimo, Comfort, Haley, Costa, Vera Marisa, Cowden, Richard G, Cromwell, Elizabeth A, Croneberger, Andrew J, Cunningham, Matthew, Dahlawi, Saad M A, Damiani, Giovanni, D'Amico, Emanuele, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, Darwesh, Aso Mohammad, Daryani, Ahmad, Das Gupta, Rajat, das Neves, José, Davletov, Kairat, De Leo, Diego, Denova-Gutiérrez, Edgar, Deribe, Kebede, Dervenis, Nikolaos, Desai, Rupak, Dhungana, Govinda Prasad, Dias da Silva, Diana, Diaz, Daniel, Dippenaar, Ilse N, Djalalinia, Shirin, Do, Hoa Thi, Dokova, Klara, Doku, David Teye, Dorostkar, Fariba, Doshi, Chirag P, Doshmangir, Leila, Doyle, Kerrie E, Dubljanin, Eleonora, Duraes, Andre Rodrigues, Edvardsson, David, Effiong, Andem, El Sayed, Iman, El Tantawi, Maha, Elbarazi, Iffat, El-Jaafary, Shaimaa I, Emamian, Mohammad Hassan, Eskandarieh, Sharareh, Esmaeilzadeh, Firooz, Estep, Kara, Farahmand, Mohammad, Faraj, Anwar, Fareed, Mohammad, Faridnia, Roghiyeh, Faro, Andre, Farzadfar, Farshad, Fattahi, Nazir, Fazaeli, Ali Akbar, Fazlzadeh, Mehdi, Feigin, Valery L, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Ferreira, Manuela L, Filip, Irina, Fischer, Florian, Flohr, Carsten, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Freitas, Marisa, Fukumoto, Takeshi, Fuller, John E, Furtado, João M, Gad, Mohamed M, Gakidou, Emmanuela, Gallus, Silvano, Gebrehiwot, Abiyu Mekonnen, Gebremedhin, Ketema Bizuwork, Gething, Peter W, Ghamari, Farhad, Ghashghaee, Ahmad, Gholamian, Asadollah, Gilani, Syed Amir, Gitimoghaddam, Mojgan, Glushkova, Ekaterina Vladimirovna, Gnedovskaya, Elena V, Gopalani, Sameer Vali, Goulart, Alessandra C, Gugnani, Harish Chander, Guo, Yuming, Gupta, Rajeev, Gupta, Subodh Sharan, Haagsma, Juanita A, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Halvaei, Iman, Hamadeh, Randah R, Hamagharib Abdullah, Kanaan, Han, Chieh, Handiso, Demelash Woldeyohannes, Hankey, Graeme J, Haririan, Hamidreza, Haro, Josep Maria, Hasaballah, Ahmed I, Hassanipour, Soheil, Hassankhani, Hadi, Hay, Simon I, Heibati, Behzad, Heidari-Soureshjani, Reza, Henny, Kiana, Henry, Nathaniel J, Herteliu, Claudiu, Heydarpour, Fatemeh, Hole, Michael K, Hoogar, Praveen, Hosgood, H Dean, Hossain, Naznin, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hoy, Damian G, Hu, Guoqing, Huda, Tanvir M, Ibitoye, Segun Emmanuel, Ikuta, Kevin S, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Imani-Nasab, Mohammad Hasan, Islam, MdMohaimenul, Iso, Hiroyasu, Iwu, Chinwe Juliana, Jaafari, Jalil, Jacobsen, Kathryn H, Jahagirdar, Deepa, Jahanmehr, Nader, Jalali, Amir, Jalilian, Farzad, James, Spencer L, Janjani, Hosna, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S, Jonas, Jost B, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Zubair, Kalani, Hamed, Kalankesh, Leila R, Kamiab, Zahra, Kanchan, Tanuj, Kapoor, Neeti, Karch, André, Karimi, Salah Eddin, Karimi, Seyed Asaad, Kassebaum, Nicholas J, Katikireddi, Srinivasa Vittal, Kawakami, Norito, Kayode, Gbenga A, Keiyoro, Peter Njenga, Keller, Cathleen, Khader, Yousef Saleh, Khalid, Nauman, Khan, Ejaz Ahmad, Khan, Maseer, Khang, Young-Ho, Khater, Amir M, Khater, Mona M, Khazaei, Salman, Khazaie, Habibolah, Khodayari, Mohammad Taghi, Khubchandani, Jagdish, Kianipour, Neda, Kim, Cho-il, Kim, Young-Eun, Kim, Yun Jin, Kinfu, Yohannes, Kisa, Adnan, Kisa, Sezer, Kissimova-Skarbek, Katarzyna, Kivimäki, Mika, Komaki, Hamidreza, Kopec, Jacek A, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Kravchenko, Michael A, Krishan, Kewal, Krohn, Kris J, Kuate Defo, Barthelemy, Kumar, G Anil, Kumar, Manasi, Kumar, Pushpendra, Kumar, Vivek, Kusuma, Dian, Kyu, Hmwe Hmwe, La Vecchia, Carlo, Lacey, Ben, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lami, Faris Hasan, Lansky, Sonia, Larson, Samantha Leigh, Larsson, Anders O, Lasrado, Savita, Lassi, Zohra S, Lazarus, Jeffrey V, Lee, Paul H, Lee, Shaun Wen Huey, Leever, Andrew T, LeGrand, Kate E, Leonardi, Matilde, Li, Shanshan, Lim, Lee-Ling, Lim, Stephen S, Linn, Shai, Lodha, Rakesh, Logroscino, Giancarlo, Lopez, Alan D, Lopukhov, Platon D, Lotufo, Paulo A, Lozano, Rafael, Lu, Alton, Lunevicius, Raimundas, Madadin, Mohammed, Maddison, Emilie R, Magdy Abd El Razek, Hassan, Magdy Abd El Razek, Muhammed, Mahasha, Phetole Walter, Mahdavi, Mokhtar Mahdavi, Malekzadeh, Reza, Mamun, Abdullah A, Manafi, Navid, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Mapoma, Chabila Christopher, Martini, Santi, Martins-Melo, Francisco Rogerlândio, Masaka, Anthony, Mastrogiacomo, Claudia I, Mathur, Manu Raj, May, Erin A, McAlinden, Colm, McGrath, John J, McKee, Martin, Mehndiratta, Man Mohan, Mehri, Fereshteh, Mehta, Kala M, Meitei, Wahengbam Bigyananda, Memiah, Peter T N, Mendoza, Walter, Menezes, Ritesh G, Mengesha, Endalkachew Worku, Mensah, George A, Meretoja, Atte, Meretoja, Tuomo J, Mestrovic, Tomislav, Michalek, Irmina Maria, Mihretie, Kebadnew Mulatu, Miller, Ted R, Mills, Edward J, Milne, George J, Mirrakhimov, Erkin M, Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei-Alavijeh, Mehdi, Misganaw, Awoke 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W, Younis, Mustafa Z, Younker, Theodore Patrick, Yousefi, Zabihollah, Yousefinezhadi, Taraneh, Yousuf, Abdilahi Yousuf, Yusefzadeh, Hasan, Zahirian Moghadam, Telma, Zakzuk, Josefina, Zaman, Sojib Bin, Zamani, Mohammad, Zamanian, Maryam, Zandian, Hamed, Zhang, Zhi-Jiang, Zheng, Peng, Zhou, Maigeng, Ziapour, Arash, and Murray, Christopher J L
- Abstract
Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019.
- Published
- 2020
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50. Five insights from the Global Burden of Disease Study 2019
- Author
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Murray, Christopher J L, Abbafati, Cristiana, Abbas, Kaja M, Abbasi, Mohammad, Abbasi-Kangevari, Mohsen, Abd-Allah, Foad, Abdollahi, Mohammad, Abedi, Parisa, Abedi, Aidin, Abolhassani, Hassan, Aboyans, Victor, Abreu, Lucas Guimarães, Abrigo, Michael R M, Abu-Gharbieh, Eman, Abu Haimed, Abdulaziz Khalid, Abushouk, Abdelrahman I, Acebedo, Alyssa, Ackerman, Ilana N, Adabi, Maryam, Adamu, Abdu A, Adebayo, Oladimeji M, Adelson, Jaimie D, Adetokunboh, Olatunji O, Afarideh, Mohsen, Afshin, Ashkan, Agarwal, Gina, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadi, Mehdi, Ahmed, Muktar Beshir, Aji, Budi, Akinyemiju, Tomi, Akombi, Blessing, Alahdab, Fares, Alam, Khurshid, Alanezi, Fahad Mashhour, Alanzi, Turki M, Albertson, Samuel B, Alemu, Biresaw Wassihun, Alemu, Yihun Mulugeta, Alhabib, Khalid F, Ali, Muhammad, Ali, Saqib, Alicandro, Gianfranco, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Alla, François, Allebeck, Peter, Almadi, Majid Abdulrahman Hamad, Almasi-Hashiani, Amir, 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- Abstract
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3·5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimatesare publicly available and adhere to the Guidelineson Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.
- Published
- 2020
- Full Text
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