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COVID-19 has affected the whole world drastically and led to a substantial loss of human life. Relentless research is underway to identify effective treatment to control the disease. Traditional systems are also being explored to search for a potent drug. Unani formulation ' Tiryāq-i-Wabāī' has long been used in cholera, plague and other epidemic diseases. This review is aimed at analysing the possible role of Tiryāq-i-Wabāī in the prevention and control of COVID-19. Unani classical texts and Pharmacopoeias available in the library of Regional Research Institute of Unani Medicine, Chennai were reviewed to collect information related to epidemics, commonly prescribed drugs during epidemics, and therapeutic uses of Tiryāq-i-Wabāī ingredients. ScienceDirect, Springer, PubMed and Google Scholar were searched to collect information regarding current pandemic and pharmacological activities of ingredients and phytoconstituents present in the formulation. The collected data was analyzed and interpreted. Tiryāq-i-Wabāī was found to be the most recommended prophylactic and curative drug during epidemics. The formulation ingredients, Sibr (Aloe vera (L.) Burm.f.), Murr Makki (Commiphora myrrha (T.Nees) Engl.) and Zāfrān (Crocus sativus L.) are categorized under Tiryāqi Advia (literally – antidote drugs) and are considered to be very effective in SARS related conditions. These ingredients have been reported to exhibit immunomodulatory, antioxidant, antiviral, antibacterial, antitussive, smooth muscle relaxant, antipyretic and anti-inflammatory activities corroborating the traditional use of Tiryāq-i-Wabāī. Scientific data imply great potential and utility of the formulation which could be a possible alternative approach for the prevention and control of current and future pandemics. • COVID-19 has become a global health menace with catastrophic social and economic consequences. • Intensive researches are underway to develop decisive treatment to control the diseases. • Unani medicine may play a major role in protecting, reducing disease burden and improving overall well-being of humanity. • Tiryāq-i-Wabāī has been widely used as prophylactic and curative drug during cholera, plague and other epidemic diseases. • Tiryāq-i-Wabāī may prove beneficial in augmenting immune resilience and protecting individuals from infection during pandemics. [ABSTRACT FROM AUTHOR]

The therapeutic approach to medicine has witnessed a shift during the last few decades and herbal drugs are now in great demand globally. Valuable research is being carried out to evaluate the safety and efficacy of herbal drugs, in search of a holistic cure for various ailments. Liver diseases, for instance, are a serious health issue. Available therapeutic options lead to noxious effects and hepatotoxicity. Cymbopogon martinii (Roxb.) Wats., commonly known as Izkhar , is a well-known drug in Unani medicine for the management of liver ailments. The review's core aim is to propose the traditional usage of Izkhar for liver disorders, as reported in ancient Unani medicine literature, as well as its scientific confirmation in light of recent studies. Critical assessment was carried out on the manuscripts of Unani medicine, like Al Qanoon Fit Tib , Khazain al-Advia, Makhzan al-Advia, Kitab al-Hawi, Muheete Azam, Al-Jami li Mufradat al-Advia wa'l Aghziya , etc. Pharmacological activities of C. martinii related to hepatic disorders were also cited from various research articles and databases, such as Science-Direct, Wiley Online Library and PubMed. The promising benefits of Izkhar were identified in respect to liver diseases. Monoterpenes, essential oils, flavonoids, phenolic acids and other chemical components were discovered during phytochemical analysis. On the basis of scientific studies, it may be concluded that C. martinii has great potential as a safe and effective drug for liver ailments. The identification of several phytoconstituents also substantiates the evidence. [Display omitted] • Liver diseases are a serious health issue and existing therapeutic options are often toxic in nature. • Challenge: Find a solution to manage hepatic disorders with effective and minimal side effects drug. • Solution: Cymbopogon martinii (Roxb.) Wats., commonly known as Izkhar in Unani medicine is a promising drug successfully used by Unani physicians for liver ailments and possess many active biomolecules proved by scientific researches. [ABSTRACT FROM AUTHOR]