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Cancer is one of the deadliest illnesses of the 21st century. Chemotherapy and radiation therapies both have considerable side effects. Antitumor antibiotics are one of them. Coughs, common colds, fevers, laryngitis, and infectious disorders have all been treated with Andrographis paniculatafor centuries. Extracts of Andrographiseffectively treat various ailments, as well as cancer. The most active molecule in Andrographis paniculatais andrographolide a, diterpene, and lactone. Andrographis paniculataand its derivatives have long been used to treat various ailments. Anti-inflammatory and cancerfighting characteristics have been observed in Andrographolide. Andrographolide, a diterpene lactone separated from Andrographis paniculata, has also been shown to have important criticalessential biological protective properties. It has also been suggested that it could be used to treat major human diseases like-rheumatoid like rheumatoid, colitis, and Parkinsons disease. This summary aims to highlight Andrographolide as a promising cancer treatment option. Several databases were searched for andrographolides cytotoxic/anti-cancer effects in pre-clinical and clinical research to serve this purpose. Several studies have shown that Andrographolide is helpful in cancer medication, as detailed in this review.

Several electronic-engagement-related questions arise at work due to the beginning of a new era of social distancing, lockdowns, quarantining, and sanitization. These terms were not so common before. What challenges do employees face while working from home? Why do they face those challenges? How are they overcoming these challenges? In summary, in a work-from-home setting, what are the issues and solutions in engaging remote workers electronically? To answer these questions, 23 Information Technology (IT) employees in India and four in the United Kingdom were interviewed, and data were analyzed using interpretive phenomenological analysis (IPA). Few Information Technology employees from the United Kingdom were also interviewed to ensure the transferability of the results. Along with a few suggestions, six challenges emerged. These may help employers formulate their electronic engagement strategies for employees in a better manner.

Recent years have been transformational for organisations owing to growing generational diversity and the associated challenges of managing the different generations working together. This issue of generational diversity invites significant attention in the context of studying organisations that are going through massive transformations with the presence of different generations within the organisations at the same time (Baby Boomers, Generation X and Generation Y or Millennials). Each of the three generations, with their understanding of the business context, technology, and industry-specific knowledge, are influencing organisational learning landscapes. With this, both the organisations and individuals benefit from the exchange of expertise suited to the learning preferences of different generational cohorts. This qualitative research is an attempt to explore the aforementioned phenomenon by focusing on the nuances of the traits of different generations, their respective learning preferences and the dynamics of intergenerational learning in the context of Indian IT companies. Insights that emerge seek to unravel the observed facets of intergenerational learning by three diverse generations of IT Industry.

Hip pain is one of the most common musculoskeletal presentations in general practice. There are multiples causes of hip pain, ranging from acute to chronic and traumatic to atraumatic. In general practice, it is important to identify the cause of hip pain, as management strategies vary depending on pathology. Some diagnoses need urgent referral to secondary care, whereas others can be managed in primary care. According to the RCGP, an estimated 1-in-5 consultations are for musculoskeletal conditions, so a good knowledge of management is important. In this article, we will discuss the anatomy of the hip, the most common causes of hip pain and their management.

Gamification, as a technique to engage members of the millennial generation, has gained considerable traction at workplace. The purpose of this study is to provide a contextual overview of gamification as an effective mechanism aligned with the learning preferences and characteristics of the millennial cohort. The suggested framework helps organizations effectively design and incorporate learning mechanisms appropriate to new cohort entering and dominating the workforce. The insights developed are critical for learning and development professionals and instructional designers in enabling them to create effective and gamified training modules for this cohort.

Peripheral arterial disease is a chronic condition that is increasingly encountered in primary care. Its symptoms not only affect the patient’s physical wellbeing, but also can have profound effects on mental health. With an ageing population, the prevalence of peripheral arterial disease is likely to increase. Early recognition and optimum medical management can minimise the progression of peripheral arterial disease, allowing patients to lead a pain-free life. This article aims to briefly summarise the common symptoms, suggest tools that can be used to aid diagnosis, and review the current literature on the management of peripheral arterial disease, including surgical options.

Objective: Defects in delivered software products not only have financial implications but also affect the reputation of the organisation and lead to wastage of time and human resources. This paper aims to detect defects in software modules. Methods: Our approach sequentially combines SMOTE algorithm with K - means clustering algorithm to deal with class imbalance problem to obtain a set of key features based on the interclass and intra-class coefficient of correlation and ensemble modeling to predict defects in software modules. After cautious examination, an ensemble framework of XGBoost, Decision Tree, and Random Forest is used for the prediction of software defects owing to numerous merits of the ensembling approach. Results: We have used five open-source datasets from NASA PROMISE repository for software engineering. The result obtained from our approach has been compared with that of individual algorithms used in the ensemble. A confidence interval for the accuracy of our approach with respect to performance evaluation metrics, namely accuracy, precision, recall, F1 score and AUC score, has also been constructed at a significance level of 0.01. Conclusion: Results have been depicted pictographically.