96 results on '"Isasi, Carmen R"'
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2. Hearing Loss and Associated 7-Year Cognitive Outcomes Among Hispanic and Latino Adults
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Stickel, Ariana M., Mendoza, Alonzo, Tarraf, Wassim, Kuwayama, Sayaka, Kaur, Sonya, Morlett Paredes, Alejandra, Daviglus, Martha L., Testai, Fernando D., Zeng, Donglin, Isasi, Carmen R., Baiduc, Rachael R., Dinces, Elizabeth, Lee, David J., and González, Hector M.
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IMPORTANCE: Hearing loss appears to have adverse effects on cognition and increases risk for cognitive impairment. These associations have not been thoroughly investigated in the Hispanic and Latino population, which faces hearing health disparities. OBJECTIVE: To examine associations between hearing loss with 7-year cognitive change and mild cognitive impairment (MCI) prevalence among a diverse cohort of Hispanic/Latino adults. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used data from a large community health survey of Hispanic Latino adults in 4 major US cities. Eligible participants were aged 50 years or older at their second visit to study field centers. Cognitive data were collected at visit 1 and visit 2, an average of 7 years later. Data were last analyzed between September 2023 and January 2024. EXPOSURE: Hearing loss at visit 1 was defined as a pure-tone average (500, 1000, 2000, and 4000 Hz) greater than 25 dB hearing loss in the better ear. MAIN OUTCOMES AND MEASURES: Cognitive data were collected at visit 1 and visit 2, an average of 7 years later and included measures of episodic learning and memory (the Brief-Spanish English Verbal Learning Test Sum of Trials and Delayed Recall), verbal fluency (word fluency—phonemic fluency), executive functioning (Trails Making Test–Trail B), and processing speed (Digit-Symbol Substitution, Trails Making Test–Trail A). MCI at visit 2 was defined using the National Institute on Aging-Alzheimer Association criteria. RESULTS: A total of 6113 Hispanic Latino adults were included (mean [SD] age, 56.4 [8.1] years; 3919 women [64.1%]). Hearing loss at visit 1 was associated with worse cognitive performance at 7-year follow-up (global cognition: β = −0.11 [95% CI, −0.18 to −0.05]), equivalent to 4.6 years of aging and greater adverse change (slowing) in processing speed (β = −0.12 [95% CI, −0.23 to −0.003]) equivalent to 5.4 years of cognitive change due to aging. There were no associations with MCI. CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that hearing loss decreases cognitive performance and increases rate of adverse change in processing speed. These findings underscore the need to prevent, assess, and treat hearing loss in the Hispanic and Latino community.
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- 2024
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3. Connections between reproductive health and cognitive aging among women enrolled in the HCHS/SOL and SOL‐INCA.
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Stickel, Ariana M., Tarraf, Wassim, Kuwayama, Sayaka, Wu, Benson, Sundermann, Erin E., Gallo, Linda C., Lamar, Melissa, Daviglus, Martha, Zeng, Donglin, Thyagarajan, Bharat, Isasi, Carmen R., Lipton, Richard B., Cordero, Christina, Perreira, Krista M., Gonzalez, Hector M., and Banks, Sarah J.
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INTRODUCTION: Reproductive health history may contribute to cognitive aging and risk for Alzheimer's disease, but this is understudied among Hispanic/Latina women. METHODS: Participants included 2126 Hispanic/Latina postmenopausal women (44 to 75 years) from the Study of Latinos‐Investigation of Neurocognitive Aging. Survey linear regressions separately modeled the associations between reproductive health measures (age at menarche, history of oral contraceptive use, number of pregnancies, number of live births, age at menopause, female hormone use at Visit 1, and reproductive span) with cognitive outcomes at Visit 2 (performance, 7‐year change, and mild cognitive impairment [MCI] prevalence). RESULTS: Younger age at menarche, oral contraceptive use, lower pregnancies, lower live births, and older age at menopause were associated with better cognitive performance. Older age at menarche was protective against cognitive change. Hormone use was linked to lower MCI prevalence. DISCUSSION: Several aspects of reproductive health appear to impact cognitive aging among Hispanic/Latina women. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Psychosocial factors associated with 7‐year change in cognition among middle‐aged and older Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos‐Investigation of Neurocognitive Aging (SOL‐INCA) and...
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Estrella, Mayra L., Tarraf, Wassim, Kuwayama, Sayaka, Gallo, Linda C., Wu, Benson, Marquine, María J., Perreira, Krista M., Vasquez, Priscilla M., Isasi, Carmen R., Lipton, Richard B., Mattei, Josiemer, González, Hector M., Daviglus, Martha L., and Lamar, Melissa
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INTRODUCTION: Few studies have examined the associations of psychosocial factors with cognitive change in Hispanics/Latinos. METHODS: Data from the Hispanic Community Health Study/Study of Latinos‐Investigation of Neurocognitive Aging (HCHS/SOL INCA) and Sociocultural studies were used (n = 2,155; ages ≥45 years). Psychosocial exposures included intrapersonal (ethnic identity, optimism, purpose in life), interpersonal (family cohesion, familism, social networks, social support), and social factors (ethnic discrimination, loneliness, subjective social status). Survey‐linear regression models examined associations between psychosocial exposures and 7‐year cognitive change (global cognition [GC], verbal learning, memory, word fluency [WF], and digit symbol substitution [DSS]). RESULTS: Familism predicted decline in GC, verbal learning, and memory; family cohesion predicted DSS decline; and loneliness predicted memory decline. Ethnic identity was protective against decline in GC and memory, optimism and social support were protective against decline in memory, and purpose in life was protective against WF decline. DISCUSSION: Psychosocial factors are differentially related to cognitive changes. Culturally relevant factors should be explored in Hispanic/Latino cognitive aging research. Highlights: Psychosocial factors are differentially related to cognitive changes in Latinos.Role of culturally relevant factors on cognition should be further explored.Familism predicted decline in global cognition, verbal learning, and memory.Ethnic identity predicted increase in global cognition and memory. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Sleep duration and brain MRI measures: Results from the SOL‐INCA MRI study.
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González, Kevin A., Tarraf, Wassim, Stickel, Ariana M., Kaur, Sonya, Agudelo, Christian, Redline, Susan, Gallo, Linda C., Isasi, Carmen R., Cai, Jianwen, Daviglus, Martha L., Testai, Fernando D., DeCarli, Charles, González, Hector M., and Ramos, Alberto R.
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INTRODUCTION: Sleep duration has been associated with dementia and stroke. Few studies have evaluated sleep pattern–related outcomes of brain disease in diverse Hispanics/Latinos. METHODS: The SOL‐INCA (Study of Latinos‐Investigation of Neurocognitive Aging) magnetic resonance imaging (MRI) study recruited diverse Hispanics/Latinos (35–85 years) who underwent neuroimaging. The main exposure was self‐reported sleep duration. Our main outcomes were total and regional brain volumes. RESULTS: The final analytic sample included n = 2334 participants. Increased sleep was associated with smaller brain volume (βtotal_brain = −0.05, p < 0.01) and consistently so in the 50+ subpopulation even after adjusting for mild cognitive impairment status. Sleeping >9 hours was associated with smaller gray (βcombined_gray = −0.17, p < 0.05) and occipital matter volumes (βoccipital_gray = −0.18, p < 0.05). DISCUSSION: We found that longer sleep duration was associated with lower total brain and gray matter volume among diverse Hispanics/Latinos across sex and background. These results reinforce the importance of sleep on brain aging in this understudied population. Highlights: Longer sleep was linked to smaller total brain and gray matter volumes.Longer sleep duration was linked to larger white matter hyperintensities (WMHs) and smaller hippocampal volume in an obstructive sleep apnea (OSA) risk group.These associations were consistent across sex and Hispanic/Latino heritage groups. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Sex Hormones and Diabetes in 45- to 74-year-old Men and Postmenopausal Women: The Hispanic Community Health Study
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Persky, Victoria, Abasilim, Chibuzor, Tsintsifas, Konstantina, Day, Tessa, Sargis, Robert M, Daviglus, Martha L, Cai, Jianwen, Freels, Sally, Unterman, Terry, Chavez, Noel, Kaplan, Robert, Isasi, Carmen R, Pirzada, Amber, Meyer, Michelle L, Talavera, Gregory A, Thyagarajan, Bharat, Peters, Brandilyn A, Madrigal, Jessica M, Grieco, Arielle, and Turyk, Mary E
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Previous studies demonstrated associations of endogenous sex hormones with diabetes. Less is known about their dynamic relationship with diabetes progression through different stages of the disease, independence of associations, and role of the hypothalamic-pituitary gonadal axis.The purpose of this analysis was to examine relationships of endogenous sex hormones with incident diabetes, prediabetes, and diabetes traits in 693 postmenopausal women and 1015 men aged 45 to 74 years without diabetes at baseline participating in the Hispanic Community Health Study/Study of Latinos and followed for 6 years. Baseline hormones included estradiol, luteinizing hormone (LH), follicle stimulating hormone (FSH), sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), and, in men, testosterone and bioavailable testosterone. Associations were analyzed using multivariable Poisson and linear regressions. In men, testosterone was inversely associated with conversion from prediabetes to diabetes (incidence rate ratio [IRR] for 1 SD increase in testosterone: 0.821; 95% CI, 0.676, 0.997; P= 0.046), but not conversion from normoglycemia to prediabetes. Estradiol was positively associated with increase in fasting insulin and homeostatic model assessment of insulin resistance. In women, SHBG was inversely associated with change in glycosylated hemoglobin, postload glucose, and conversion from prediabetes to diabetes (IRR = 0.62; 95% CI, 0.44, 0.86, P= 0.005) but not from normoglycemia to prediabetes. Relationships with other hormones varied across glycemic measures. Stronger associations of testosterone and SHBG with transition from prediabetes to diabetes than from normoglycemic to prediabetes suggest they are operative at later stages of diabetes development. Biologic pathways by which sex hormones affect glucose homeostasis await future studies.
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- 2023
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7. A Gene-Acculturation Study of Obesity Among US Hispanic/Latinos: The Hispanic Community Health Study/Study of Latinos
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Fernández-Rhodes, Lindsay, McArdle, Cristin E., Rao, Hridya, Wang, Yujie, Martinez-Miller, Erline E., Ward, Julia B., Cai, Jianwen, Sofer, Tamar, Isasi, Carmen R., and North, Kari E.
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- 2023
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8. Association of Acculturation and Hispanic/Latino Background with Endogenous Sex and Thyroid-Related Hormones Among Middle-Aged and Older Hispanic/Latino Adults: the HCHS/SOL Study
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Abasilim, Chibuzor, Persky, Victoria, Sargis, Robert M., Argos, Maria, Daviglus, Martha L., Freels, Sally, Tsintsifas, Konstantina, Day, Tessa, Cai, Jianwen, Isasi, Carmen R., Peters, Brandilyn A., Talavera, Gregory A., Thyagarajan, Bharat, and Turyk, Mary E.
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Background: Hormones are linked to cardiometabolic diseases and may be impacted by acculturation though multiple mechanisms. We evaluated associations of Hispanic/Latino background and acculturation with levels of sex- and thyroid-related hormones and the potential mediating effect of adiposity, lifestyle factors, and sleep apnea syndrome on these associations. Methods: We studied 1789 adults, aged 45–74, from a sub-cohort of the Hispanic Community Health Survey/Study of Latinos. Peri/pre-menopausal women and individuals on medications related to hormones were excluded. Our study assessed eleven sex- and thyroid-related hormones, Hispanic/Latino background, and five acculturation measures. Associations were assessed using multivariable linear and logistic regression adjusted for survey design and confounding variables. We explored potential mediation using a path analysis. Results: In postmenopausal women, acculturation score-MESA was associated with decreased thyroid-stimulating hormone (β= − 0.13;95%CI = − 0.22, − 0.03) while age at immigration greater than the median (vs US-born) was associated with decreased (β= − 14.6; 95%CI = − 28.2, − 0.99) triiodothyronine (T3). In men, language acculturation and acculturation score-MESA were associated with increased estradiol and sex hormone-binding globulin (SHBG) while age at immigration greater and lesser than the median (vs US-born) was associated with decreased SHBG. Hispanic/Latino background (Mexicans as reference) were selectively associated with sex- and thyroid-related hormone levels in both sexes. Current smoking and sleep apnea syndrome partially mediated the association of Cuban and Puerto Rican heritage (vs Mexican) with T3 levels in men and postmenopausal women, respectively. Conclusion: Selected acculturation measures were associated with thyroid-related hormones in postmenopausal women and sex-related hormones in men. Understanding the mechanisms involved in the relationship of acculturation and Hispanic/Latino background with hormones warrants additional investigation.
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- 2023
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9. Impact of COVID-19 pandemic on research and careers of early career researchers: a DOHaD perspective
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Bansal, Amita, Abruzzese, Giselle A., Hewawasam, Erandi, Hasebe, Kyoko, Hamada, Hirotaka, Hoodbhoy, Zahra, Diounou, Hanna, Ibáñez, Carlos A., Miranda, Rosiane A., Golden, Thea N., Miliku, Kozeta, and Isasi, Carmen R.
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AbstractThe COVID-19 pandemic has exposed several inequalities worldwide, including the populations' access to healthcare systems and economic differences that impact the access to vaccination, medical resources, and health care services. Scientific research activities were not an exception, such that scientific research was profoundly impacted globally. Research trainees and early career researchers (ECRs) are the life force of scientific discovery around the world, and their work and progress in research was dramatically affected by the COVID-19 pandemic. ECRs are a particularly vulnerable group as they are in a formative stage of their scientific careers, any disruptions during which is going to likely impact their lifelong career trajectory. To understand how COVID-19 impacted lives, career development plans, and research of Developmental Origins of Health and Disease (DOHaD) ECRs, the International DOHaD ECR committee formed a special interest group comprising of ECR representatives of International DOHaD affiliated Societies/Chapters from around the world (Australia and New Zealand, Canada, French Speaking DOHaD, Japan, Latin America, Pakistan and USA). The anecdotal evidence summarized in this brief report, provide an overview of the findings of this special interest group, specifically on the impact of the evolving COVID-19 pandemic on daily research activities and its effects on career development plans of ECRs. We also discuss how our learnings from these shared experiences can strengthen collaborative work for the current and future generation of scientists.
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- 2022
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10. Chronic Stress, Genetic Risk, and Obesity in US Hispanic/Latinos: Results From the Hispanic Community Health Study/Study of Latinos
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Isasi, Carmen R., Moon, Jee-Young, Gallo, Linda C., Qi, Qibin, Wang, Tao, Sotres-Alvarez, Daniela, Llabre, Maria M., Khambaty, Tasneem, Daviglus, Martha, Estrella, Mayra L., Cai, Jianwen, and Kaplan, Robert
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- 2022
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11. Subjective cognitive decline and objective cognition among diverse U.S. Hispanics/Latinos: Results from the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA).
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Zlatar, Zvinka Z., Tarraf, Wassim, González, Kevin A., Vásquez, Priscilla M., Marquine, María J., Lipton, Richard B., Gallo, Linda C., Khambaty, Tasneem, Zeng, Donglin, Youngblood, Marston E., Estrella, Mayra L., Isasi, Carmen R., Daviglus, Martha, and González, Hector M.
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Introduction: Despite increased risk of cognitive decline in Hispanics/Latinos, research on early risk markers of Alzheimer’s disease in this group is lacking. Subjective cognitive decline (SCD) may be an early risk marker of pathological aging. We investigated associations of SCD with objective cognition among a diverse sample of Hispanics/Latinos living in the United States. Methods: SCD was measured with the Everyday Cognition Short Form (ECog-12) and cognitive performance with a standardized battery in 6125 adults aged ≥ 50 years without mild cognitive impairment or dementia (x̄
age = 63.2 years, 54.5% women). Regression models interrogated associations of SCD with objective global, memory, and executive function scores. Results: Higher SCD was associated with lower objective global (B = −0.16, SE = 0.01), memory (B = −0.13, SE = 0.02), and executive (B = −0.13, SE = 0.02, p’s < .001) function composite scores in fully adjusted models. Discussion: Self-reported SCD, using the ECog-12, may be an indicator of concurrent objective cognition in diverse middle-aged and older community-dwelling Hispanics/Latinos. [ABSTRACT FROM AUTHOR]- Published
- 2022
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12. MRI Statistical region of interest best differentiates impaired from non‐impaired in the Study of Latinos‐Investigation of Neurocognitive Aging‐MRI (SOL‐INCA‐MRI).
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Fletcher, Evan M, Gallo, Linda C, Talavera, Gregory A, Isasi, Carmen R, Kaplan, Robert, Lipton, Richard B., Daviglus, Martha L, Schneiderman, Neil, Gellman, Marc D, Stickel, Ariana M, Tarraf, Wassim, González, Hector M, and DeCarli, Charles S.
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Background: We developed a statistical region of interest (sROI) of gray matter (GM) for which cortical thickness (CT) significantly differed in a "training set" of 100 cognitively normal and 100 individuals with incident dementia in the Framingham Heart Study. sROI significantly predicts incident cognitive impairment and dementia in both FHS and the highly diverse UC Davis Alzheimer's disease longitudinal cohort. Here we describe a similar analysis of participants of Study of Latinos‐Investigation of Neurocognitive Aging‐MRI (SOL‐INCA‐MRI). Methods: Hispanics/Latinos (n=6,377 ages 50‐86) were enrolled in the Study of Latinos ‐ Investigation of Neurocognitive Aging (SOL‐INCA) of which 1,143 also participated in SOL‐INCA‐MRI ancillary study. Cognitive impairment (CI) was defined as any cognitive domain score falling below (<‐1.0 SD) the SOL‐INCA robust internal normative mean and significant cognitive decline (‐0.055 SD/yr), self‐reported cognitive decline and no or minimal functional impairment over 7 years. Participants with dementia were excluded. MRI CT was computed by the DiReCT method. sROI was derived from statistically significant (via 1,000 non‐parametric permutations) clusters of GM voxels having CT group difference t > 2 over the training set (Fig. 1). Extents of sROI overlap with standard atlas GM regions appear in Table 3. Group differences in variables were assessed by t‐test. Logistic regression assessed the impact on cognitive status of MRI factors: total brain, hippocampal, white matter hyperintensities (WMH), sROI volumes and infarction occurrence, controlling for age, sex, education, and background. Results: The cohort was 64.4 + 7 years of age, 69% female. Nearly 60% with high school or less education, and 21% CI. Table 1 summarizes demographic and MRI measures for CI and cognitively normal (CN). CI individuals were older, had less education, smaller brains, and greater amounts of WMH. Table 2 summarizes results of logistic regression. Education and sROI mean CT were the only significant predictors of cognitive status. Conclusion: Cortical thickness within the sROI was strongly associated with cognitive status, even when other commonly used MRI measures were not. sROI may therefore be a sensitive indicator of incipient CI within SOL‐INCA‐MRI where more traditional measures of Alzheimer's pathology and vascular disease appear insensitive. [ABSTRACT FROM AUTHOR]
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- 2022
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13. Association of Hispanic/Latino background and brain structure in Hispanics/Latinos from the SOL‐INCA MRI study.
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DeCarli, Charles S., Tarraf, Wassim, Gonzalez, Kevin A, Stickel, Ariana M, Fletcher, Evan M, Knaack, Alexander, Maillard, Pauline, Gallo, Linda C, Daviglus, Martha L, Testai, Fenando D, Isasi, Carmen R, Schneiderman, Neil, Sofer, Tamar, Fornage, Myriam, and Gonzalez, Hector M
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Background: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a representative, community‐based study of Hispanics and Latinos across the US that seeks to understand health disparities within this heterogeneous population. The Study of Latinos ‐ Investigation of Neurocognitive Aging MRI (SOL‐INCA MRI) is an ancillary MRI study to HCHS/SOL focused on the genetic influence and cognitive impact of age‐ and disease‐related brain measures. Brain structure undergoes substantial development and remodeling from birth through adulthood. Intracranial volume is a measure of maximum brain development, which is under substantial genetic and environmental influences, and is an independent marker of cognitive resilience. We report the influence of self‐described background on intracranial volume, brain tissue and cortical thickness measures for 1388 individuals studied to date. Method: Hispanics and Latinos (ages 35.9‐85.2 years; 66% female) underwent MRI and analysis at the Imaging of Dementia and Aging (IDeA) laboratory using previously published methods. MRI outcomes of interest included supratentorial intracranial volume (TCV), image segmentation into white matter, gray matter, total brain, and regional cortical thickness. Background was categorized as Cuban, Central American, Dominican, Mexican, Puerto Rican and South American. We performed association analysis using linear regression models accounting for sex, height, background, and their interactions. Result: Height was positively associated with TCV. Women had significantly smaller TCV than men (Table 1). TCV did not vary significantly with age. After adjusting for age, gender, height, and interactions, TCV measures varied significantly by background, and were greatest for Dominicans. Cuban’s and Mexican’s TCV measures were significantly smaller than Dominican’s (Figure 1). Cerebral gray matter volume as a residual of TCV was also significantly greater for Dominicans as compared to all other backgrounds (Table 2). Residuals of brain, gray and white matter varied significantly across backgrounds (Figure 2). Finally, cortical thickness measures varied significantly by background and brain region, being greatest for both Dominicans and Puerto Ricans (Figure 3). Conclusion: Brain development results from multiple factors including gene, environment, and gene‐environment interactions. Investigating the genetic and environmental causes of the heterogeneity of brain measures in SOL‐INCA‐MRI are likely to lead to discoveries related to both brain development and possibly brain aging. [ABSTRACT FROM AUTHOR]
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- 2021
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14. The association of childhood socio‐economic position with later life brain structure in individuals of Hispanic/Latino background. Preliminary results from the INCA‐MRI study.
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Isasi, Carmen R, Filigrana, Paola, Moon, Jee‐Young, Lipton, Richard B., Gallo, Linda C, Kaplan, Robert, Daviglus, Martha L, Testai, Fenando D, Marquine, Maria J., Cai, Jianwen, Schneiderman, Neil, Perreira, Krista M, Stickel, Ariana M, González, Hector M, and Decarli, Charles
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Background: Childhood is a period of brain plasticity when environmental influences may have long‐lasting effects. Early socio‐economic position (SEP) may influence brain development at vulnerable stages and set the stage for increased vulnerability to Alzheimer's Disease and related dementias (ADRD). In this study, we evaluated whether childhood SEP was related to brain structure in adulthood. Methods: This analysis included the first 1320 individuals (61% women, age range 50‐85) of diverse Hispanic/Latino background with brain magnetic resonance imaging (MRI) assessments from the HCHS/SOL INCA‐MRI study, conducted at four major urban areas (Bronx, NY; Chicago, IL; Miami, FL, and San Diego, CA). Childhood SEP was assessed by self‐reported maternal educational achievement. We also calculated the difference between attained height and genetically predicted height using height‐associated SNPs, sex, and genetic ancestry as a biomarker of early environmental exposures. Positive values indicate taller attained stature than the expected based on SNPs, suggesting favorable early environmental influence on height; negative values suggest environmental conditions limiting growth. Measures of brain structure [total intracranial volume (TICV), total gray matter volume (TGMV) and hippocampus volume (HV)] were obtained using MRI with standardized procedures. Survey linear regression models were conducted adjusting for potential confounders. Results: Low parental educational achievement was common, 55% of mothers completed less than a middle school education. In multivariable linear regression models, higher maternal educational achievement was associated with some measures of brain structure, such as greater TICV (b = 18.6, p<.001 for high school (HS) graduate; b = 26.2, p<.01 for > HS; reference <6 grade), higher TGMV (b = 5.8, p<.02 for HS graduate; b = 5.4, p<.10 for > HS), and higher HV (b = 0.14, p<.01 for HS graduate; b = 0.03, p = NS for greater than HS). Early life factors affecting height were associated with lower TICV (b = ‐18.9, p<.001), lower TGMV (b = ‐6.4, p<.001), and lower HV (b = ‐0.6, p<.01). Conclusion: This study showed associations of early childhood socio‐economic position with brain structure assessed in later adulthood. Findings suggest that height residual is a useful predictor of early life environment affecting later life brain volumes. [ABSTRACT FROM AUTHOR]
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- 2023
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15. Childhood and life‐course socioeconomic position and cognitive function in adult population of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
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Filigrana, Paola, Moon, Jee‐Young, Gallo, Linda C, Fernandez‐Rhodes, Lindsay E, Perreira, Krista M, Daviglus, Martha L, Thyagarajan, Bharat, Garcia‐Bedoya, Olga L, Cai, Jianwen, Lipton, Richard B., Kaplan, Robert C., González, Hector M, and Isasi, Carmen R
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Background: The Hispanic/Latino population experiences extensive socioeconomic adversity across the lifespan and is at greater risk of cognitive decline. Yet little is known about the role of life‐course socioeconomic position (SEP) and cognitive function in this population. We assessed the association between childhood SEP and cognitive function in Hispanic/Latino adults, whether this association is mediated by midlife SEP, and whether socioeconomic mobility is associated with cognitive function. Method: We used baseline data (2008‐2011) from 9556 adults aged 45‐74 years of the Hispanic Community Health Study/Study of Latino (HCHS/SOL), a multi‐center cohort study conducted in four major U.S cities. We determined childhood SEP using parental educational attainment. Midlife SEP was determined through an index combining participants' education and household income. We classified participants into socioeconomic mobility categories from childhood to adulthood (e.g., persisting low, upward mobility). Cognitive function was ascertained using neurocognitive tests, including the Six‐Item Screener; Brief‐Spanish English Verbal Learning Test Sum and Recall, Controlled Oral Word Association (or Word Frequency), and the Digit Symbol Substitution Test. Using confirmatory factor analysis and these tests we created a global cognition score. We also standardized z‐score of these neurocognitive measures. Survey linear regression models were performed adjusting for age, sex, Hispanic background, U.S born, smoking, depression, and cardiovascular factors. We also conducted mediation analysis to decompose the direct effect of childhood SEP on cognition and the indirect effect through midlife SEP. Result: Childhood SEP showed a graded association with cognitive function in adulthood with a dose‐response relationship across levels of parental education (β and [95% Confidence Interval (CI)]): Elementary/middle school vs. No schooling 0.34 [0.25‐0.43]; High school (HS) vs. No schooling: 0.53 [0.42‐0.64]; and >HS vs. No schooling: 0.68 [0.57‐0.79]). High midlife SEP was also associated with greater cognitive function relative to low midlife SEP. 37% (95% CI 32%‐44%) of the association between childhood SEP and cognition was mediated through midlife SEP. Holding a high SEP over the life‐course was associated with greater cognitive performance (β: 0.90, 95% CI: 0.79‐1.00) as compared with a persisting low SEP. Conclusion: This study provides evidence that childhood and life‐course SEP influence cognitive performance in adulthood [ABSTRACT FROM AUTHOR]
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- 2023
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16. Multimodal associations of physical exercise, diet, body mass index, and sleep on white matter injury: The SOL‐INCA‐MRI study.
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Sapkota, Shraddha, Maillard, Pauline, Stickel, Ariana M, Tarraf, Wassim, Gonzalez, Kevin A, Ivanovic, Vladimir, Paredes, Alejandra Morlett, Zeng, Donglin, Cai, Jianwen, Isasi, Carmen R, Kaplan, Robert C., Lipton, Richard B., Daviglus, Martha L, Testai, Fernando Daniel, Lamar, Melissa, Gallo, Linda C, Talavera, Gregory A, Gellman, Marc D, Ramos, Alberto R, and González, Hector M
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Background: Everyday modifiable lifestyle factors play a crucial role in the development and maintenance of successful cognitive and neurodegenerative trajectories in later life. Although research has focused on independent associations of physical exercise (PE), diet, body mass index (BMI), and sleep, how all four factors simultaneously work in a larger multimodal association has not been studied. We examine the synergistic associations of all four risk factors to predict two markers of future white matter injury (cerebral free water [FW] content, a sensitive and early biomarker of white matter injury and white matter hyperintensities [WMH]) in Hispanic/Latino‐population. Method: We used cognitively normal older adults (n = 1386; mean age = 50.96(10.14) years; 66.2% female) with cross‐sectional data from the Study of Latinos‐Investigation of Neurocognitive Aging‐Magnetic Resonance Imaging (SOL‐INCA‐MRI). First, we applied path analyses to test independent associations of diet(Healthy‐Eating‐Index‐2010), PE(total activity), BMI, and sleep‐duration (measured 2008‐2015) on FW and WMH (measured 2018‐2022). Higher PE score represents lower exercise. Second, we tested mediations using significant independent predictors of FW and WMH. Third, we explored the best possible models that incorporated all six factors. We accounted for age, sex, and education in the final model. Result: First, lower PE predicted greater WMH (β = 0.171,SE = 0.064,p = 0.008) and FW (β = 0.004,SE = 0.002, p = 0.013). Higher BMI (β = 0.018,SE = 0.007, p = 0.017), and higher FW (β = 22.230,SE = 0.939, p<0.001) was associated with greater WMH. Second, we did not find that any of the three modifiable factors mediated the relationship between PE and FW. However, the association between PE and WMH was mediated by BMI (indirect model[borderline]:β = 0.012,SE = 0.006, p = 0.050) and by FW (indirect model:β = 0.066,SE = 0.025, p = 0.007). Third, the addition of diet and sleep in this double mediation model strengthened both mediations (PE→BMI→WMH:β = 0.012,SE = 0.006, p = 0.039; PE→FW→WMH:β = 0.065,SE = 0.025, p = 0.008) resulting in an overall indirect model (PE→BMI→WMH+ PE→FW→WMH:β = 0.077,SE = 0.025,p = 0.002) (Figure 1). Better diet was associated with lower BMI (β = ‐0.026,SE = 0.012,p = 0.029) and lower PE with more sleep (β = 0.190,SE = 0.061,p = 0.002). Conclusion: We observed that the association between PE and WMH is mediated by both BMI and FW, and the overall double mediation is clearer when diet and sleep are accounted for in the model. Our complex multimodal model provides a potential framework on how everyday modifiable risk factors synergistically predict WMH years later. [ABSTRACT FROM AUTHOR]
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- 2023
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17. Cognitive profiles are associated with brain morphometry years later in Hispanics/Latinos: Preliminary findings from the SOL‐INCA‐MRI study.
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Sapkota, Shraddha, Maillard, Pauline, Stickel, Ariana M, Tarraf, Wassim, Gonzalez, Kevin A, Ivanovic, Vladimir, Paredes, Alejandra Morlett, Zeng, Donglin, Cai, Jianwen, Isasi, Carmen R, Kaplan, Robert C., Lipton, Richard B., Daviglus, Martha L, Testai, Fernando Daniel, Lamar, Melissa, Gallo, Linda C, Talavera, Gregory A, Gellman, Marc D, Ramos, Alberto R, and González, Hector M
- Abstract
Background: Hispanics/Latinos are the largest and most diverse ethnoracial group at high risk for Alzheimer's disease and related dementias across the US. However, this population is largely understudied. We present preliminary findings on the association between cognitive profiles and brain morphometry measures in a large Hispanic/Latino cohort of older adults. Method: We used a longitudinal cohort of cognitively normal older adults (n = 2028; mean baseline age = 54.19 (6.75) years, 69.5% female) from the Study of Latinos‐Investigation of Neurocognitive Aging‐Magnetic Resonance Imaging (SOL‐INCA‐MRI). First, to establish a latent memory variable, we examined confirmatory factor analysis to test loadings of four manifest variables (Spanish‐English‐Verbal‐Learning Test learning and recall, digit symbol, word frequency) at the first (2008‐2015) and second (2015‐2021) cognitive visits. Second, we examined whether tertiles of our latent cognitive score were associated with two measures of brain integrity (white matter hyperintensities [WMH] and hippocampus) measured between 2018‐2022. The brain morphometry measures were regressed independently on cognitive tertiles at both visits. Age at each visit, sex, education, Hispanic/Latino background, and cognitive‐MRI lag time were included as covariates. Result: First, a two‐factor latent memory profile (episodic memory and working memory) best represented our four manifest variables at both visits 1 and 2. Each tertile corresponded to low (1), intermediate (2), and high (3) performing groups. Second, increase in cognitive tertile (from low to intermediate to high) on episodic memory (β = ‐0.157, SE = 0.040, p< 0.001) and working memory (β = ‐0.192, SE = 0.043, p< 0.001) at visit 1 was associated with lower WMH. Increase in cognitive tertile on episodic and working memory at visit 2 was associated with lower WMH (β = ‐0.241, SE = 0.036, p< 0.001 and β = ‐0.260, SE = 0.043, p< 0.001, respectively) and greater hippocampus (β = 0.051, SE = 0.015, p = 0.001 and β = 0.040, SE = 0.018, p = 0.025, respectively). Conclusion: Our preliminary findings showed that cognitive profiles and key brain integrity measures are associated years later in Hispanic/Latino adults. Careful monitoring of cognitive aging profiles in the Hispanic/Latino community may lead to early detection and intervention of older adults at high risk for future neurodegeneration. [ABSTRACT FROM AUTHOR]
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- 2023
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18. A saturated map of common genetic variants associated with human height
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Yengo, Loïc, Vedantam, Sailaja, Marouli, Eirini, Sidorenko, Julia, Bartell, Eric, Sakaue, Saori, Graff, Marielisa, Eliasen, Anders U., Jiang, Yunxuan, Raghavan, Sridharan, Miao, Jenkai, Arias, Joshua D., Graham, Sarah E., Mukamel, Ronen E., Spracklen, Cassandra N., Yin, Xianyong, Chen, Shyh-Huei, Ferreira, Teresa, Highland, Heather H., Ji, Yingjie, Karaderi, Tugce, Lin, Kuang, Lüll, Kreete, Malden, Deborah E., Medina-Gomez, Carolina, Machado, Moara, Moore, Amy, Rüeger, Sina, Sim, Xueling, Vrieze, Scott, Ahluwalia, Tarunveer S., Akiyama, Masato, Allison, Matthew A., Alvarez, Marcus, Andersen, Mette K., Ani, Alireza, Appadurai, Vivek, Arbeeva, Liubov, Bhaskar, Seema, Bielak, Lawrence F., Bollepalli, Sailalitha, Bonnycastle, Lori L., Bork-Jensen, Jette, Bradfield, Jonathan P., Bradford, Yuki, Braund, Peter S., Brody, Jennifer A., Burgdorf, Kristoffer S., Cade, Brian E., Cai, Hui, Cai, Qiuyin, Campbell, Archie, Cañadas-Garre, Marisa, Catamo, Eulalia, Chai, Jin-Fang, Chai, Xiaoran, Chang, Li-Ching, Chang, Yi-Cheng, Chen, Chien-Hsiun, Chesi, Alessandra, Choi, Seung Hoan, Chung, Ren-Hua, Cocca, Massimiliano, Concas, Maria Pina, Couture, Christian, Cuellar-Partida, Gabriel, Danning, Rebecca, Daw, E. Warwick, Degenhard, Frauke, Delgado, Graciela E., Delitala, Alessandro, Demirkan, Ayse, Deng, Xuan, Devineni, Poornima, Dietl, Alexander, Dimitriou, Maria, Dimitrov, Latchezar, Dorajoo, Rajkumar, Ekici, Arif B., Engmann, Jorgen E., Fairhurst-Hunter, Zammy, Farmaki, Aliki-Eleni, Faul, Jessica D., Fernandez-Lopez, Juan-Carlos, Forer, Lukas, Francescatto, Margherita, Freitag-Wolf, Sandra, Fuchsberger, Christian, Galesloot, Tessel E., Gao, Yan, Gao, Zishan, Geller, Frank, Giannakopoulou, Olga, Giulianini, Franco, Gjesing, Anette P., Goel, Anuj, Gordon, Scott D., Gorski, Mathias, Grove, Jakob, Guo, Xiuqing, Gustafsson, Stefan, Haessler, Jeffrey, Hansen, Thomas F., Havulinna, Aki S., Haworth, Simon J., He, Jing, Heard-Costa, Nancy, Hebbar, Prashantha, Hindy, George, Ho, Yuk-Lam A., Hofer, Edith, Holliday, Elizabeth, Horn, Katrin, Hornsby, Whitney E., Hottenga, Jouke-Jan, Huang, Hongyan, Huang, Jie, Huerta-Chagoya, Alicia, Huffman, Jennifer E., Hung, Yi-Jen, Huo, Shaofeng, Hwang, Mi Yeong, Iha, Hiroyuki, Ikeda, Daisuke D., Isono, Masato, Jackson, Anne U., Jäger, Susanne, Jansen, Iris E., Johansson, Ingegerd, Jonas, Jost B., Jonsson, Anna, Jørgensen, Torben, Kalafati, Ioanna-Panagiota, Kanai, Masahiro, Kanoni, Stavroula, Kårhus, Line L., Kasturiratne, Anuradhani, Katsuya, Tomohiro, Kawaguchi, Takahisa, Kember, Rachel L., Kentistou, Katherine A., Kim, Han-Na, Kim, Young Jin, Kleber, Marcus E., Knol, Maria J., Kurbasic, Azra, Lauzon, Marie, Le, Phuong, Lea, Rodney, Lee, Jong-Young, Leonard, Hampton L., Li, Shengchao A., Li, Xiaohui, Li, Xiaoyin, Liang, Jingjing, Lin, Honghuang, Lin, Shih-Yi, Liu, Jun, Liu, Xueping, Lo, Ken Sin, Long, Jirong, Lores-Motta, Laura, Luan, Jian’an, Lyssenko, Valeriya, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamakou, Vasiliki, Mangino, Massimo, Manichaikul, Ani, Marten, Jonathan, Mattheisen, Manuel, Mavarani, Laven, McDaid, Aaron F., Meidtner, Karina, Melendez, Tori L., Mercader, Josep M., Milaneschi, Yuri, Miller, Jason E., Millwood, Iona Y., Mishra, Pashupati P., Mitchell, Ruth E., Møllehave, Line T., Morgan, Anna, Mucha, Soeren, Munz, Matthias, Nakatochi, Masahiro, Nelson, Christopher P., Nethander, Maria, Nho, Chu Won, Nielsen, Aneta A., Nolte, Ilja M., Nongmaithem, Suraj S., Noordam, Raymond, Ntalla, Ioanna, Nutile, Teresa, Pandit, Anita, Christofidou, Paraskevi, Pärna, Katri, Pauper, Marc, Petersen, Eva R. B., Petersen, Liselotte V., Pitkänen, Niina, Polašek, Ozren, Poveda, Alaitz, Preuss, Michael H., Pyarajan, Saiju, Raffield, Laura M., Rakugi, Hiromi, Ramirez, Julia, Rasheed, Asif, Raven, Dennis, Rayner, Nigel W., Riveros, Carlos, Rohde, Rebecca, Ruggiero, Daniela, Ruotsalainen, Sanni E., Ryan, Kathleen A., Sabater-Lleal, Maria, Saxena, Richa, Scholz, Markus, Sendamarai, Anoop, Shen, Botong, Shi, Jingchunzi, Shin, Jae Hun, Sidore, Carlo, Sitlani, Colleen M., Slieker, Roderick C., Smit, Roelof A. J., Smith, Albert V., Smith, Jennifer A., Smyth, Laura J., Southam, Lorraine, Steinthorsdottir, Valgerdur, Sun, Liang, Takeuchi, Fumihiko, Tallapragada, Divya Sri Priyanka, Taylor, Kent D., Tayo, Bamidele O., Tcheandjieu, Catherine, Terzikhan, Natalie, Tesolin, Paola, Teumer, Alexander, Theusch, Elizabeth, Thompson, Deborah J., Thorleifsson, Gudmar, Timmers, Paul R. H. J., Trompet, Stella, Turman, Constance, Vaccargiu, Simona, van der Laan, Sander W., van der Most, Peter J., van Klinken, Jan B., van Setten, Jessica, Verma, Shefali S., Verweij, Niek, Veturi, Yogasudha, Wang, Carol A., Wang, Chaolong, Wang, Lihua, Wang, Zhe, Warren, Helen R., Bin Wei, Wen, Wickremasinghe, Ananda R., Wielscher, Matthias, Wiggins, Kerri L., Winsvold, Bendik S., Wong, Andrew, Wu, Yang, Wuttke, Matthias, Xia, Rui, Xie, Tian, Yamamoto, Ken, Yang, Jingyun, Yao, Jie, Young, Hannah, Yousri, Noha A., Yu, Lei, Zeng, Lingyao, Zhang, Weihua, Zhang, Xinyuan, Zhao, Jing-Hua, Zhao, Wei, Zhou, Wei, Zimmermann, Martina E., Zoledziewska, Magdalena, Adair, Linda S., Adams, Hieab H. H., Aguilar-Salinas, Carlos A., Al-Mulla, Fahd, Arnett, Donna K., Asselbergs, Folkert W., Åsvold, Bjørn Olav, Attia, John, Banas, Bernhard, Bandinelli, Stefania, Bennett, David A., Bergler, Tobias, Bharadwaj, Dwaipayan, Biino, Ginevra, Bisgaard, Hans, Boerwinkle, Eric, Böger, Carsten A., Bønnelykke, Klaus, Boomsma, Dorret I., Børglum, Anders D., Borja, Judith B., Bouchard, Claude, Bowden, Donald W., Brandslund, Ivan, Brumpton, Ben, Buring, Julie E., Caulfield, Mark J., Chambers, John C., Chandak, Giriraj R., Chanock, Stephen J., Chaturvedi, Nish, Chen, Yii-Der Ida, Chen, Zhengming, Cheng, Ching-Yu, Christophersen, Ingrid E., Ciullo, Marina, Cole, John W., Collins, Francis S., Cooper, Richard S., Cruz, Miguel, Cucca, Francesco, Cupples, L. Adrienne, Cutler, Michael J., Damrauer, Scott M., Dantoft, Thomas M., de Borst, Gert J., de Groot, Lisette C. P. G. M., De Jager, Philip L., de Kleijn, Dominique P. V., Janaka de Silva, H., Dedoussis, George V., den Hollander, Anneke I., Du, Shufa, Easton, Douglas F., Elders, Petra J. M., Eliassen, A. Heather, Ellinor, Patrick T., Elmståhl, Sölve, Erdmann, Jeanette, Evans, Michele K., Fatkin, Diane, Feenstra, Bjarke, Feitosa, Mary F., Ferrucci, Luigi, Ford, Ian, Fornage, Myriam, Franke, Andre, Franks, Paul W., Freedman, Barry I., Gasparini, Paolo, Gieger, Christian, Girotto, Giorgia, Goddard, Michael E., Golightly, Yvonne M., Gonzalez-Villalpando, Clicerio, Gordon-Larsen, Penny, Grallert, Harald, Grant, Struan F. A., Grarup, Niels, Griffiths, Lyn, Gudnason, Vilmundur, Haiman, Christopher, Hakonarson, Hakon, Hansen, Torben, Hartman, Catharina A., Hattersley, Andrew T., Hayward, Caroline, Heckbert, Susan R., Heng, Chew-Kiat, Hengstenberg, Christian, Hewitt, Alex W., Hishigaki, Haretsugu, Hoyng, Carel B., Huang, Paul L., Huang, Wei, Hunt, Steven C., Hveem, Kristian, Hyppönen, Elina, Iacono, William G., Ichihara, Sahoko, Ikram, M. Arfan, Isasi, Carmen R., Jackson, Rebecca D., Jarvelin, Marjo-Riitta, Jin, Zi-Bing, Jöckel, Karl-Heinz, Joshi, Peter K., Jousilahti, Pekka, Jukema, J. Wouter, Kähönen, Mika, Kamatani, Yoichiro, Kang, Kui Dong, Kaprio, Jaakko, Kardia, Sharon L. R., Karpe, Fredrik, Kato, Norihiro, Kee, Frank, Kessler, Thorsten, Khera, Amit V., Khor, Chiea Chuen, Kiemeney, Lambertus A. L. M., Kim, Bong-Jo, Kim, Eung Kweon, Kim, Hyung-Lae, Kirchhof, Paulus, Kivimaki, Mika, Koh, Woon-Puay, Koistinen, Heikki A., Kolovou, Genovefa D., Kooner, Jaspal S., Kooperberg, Charles, Köttgen, Anna, Kovacs, Peter, Kraaijeveld, Adriaan, Kraft, Peter, Krauss, Ronald M., Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lange, Leslie A., Langenberg, Claudia, Launer, Lenore J., Le Marchand, Loic, Lee, Hyejin, Lee, Nanette R., Lehtimäki, Terho, Li, Huaixing, Li, Liming, Lieb, Wolfgang, Lin, Xu, Lind, Lars, Linneberg, Allan, Liu, Ching-Ti, Liu, Jianjun, Loeffler, Markus, London, Barry, Lubitz, Steven A., Lye, Stephen J., Mackey, David A., Mägi, Reedik, Magnusson, Patrik K. E., Marcus, Gregory M., Vidal, Pedro Marques, Martin, Nicholas G., März, Winfried, Matsuda, Fumihiko, McGarrah, Robert W., McGue, Matt, McKnight, Amy Jayne, Medland, Sarah E., Mellström, Dan, Metspalu, Andres, Mitchell, Braxton D., Mitchell, Paul, Mook-Kanamori, Dennis O., Morris, Andrew D., Mucci, Lorelei A., Munroe, Patricia B., Nalls, Mike A., Nazarian, Saman, Nelson, Amanda E., Neville, Matt J., Newton-Cheh, Christopher, Nielsen, Christopher S., Nöthen, Markus M., Ohlsson, Claes, Oldehinkel, Albertine J., Orozco, Lorena, Pahkala, Katja, Pajukanta, Päivi, Palmer, Colin N. A., Parra, Esteban J., Pattaro, Cristian, Pedersen, Oluf, Pennell, Craig E., Penninx, Brenda W. J. H., Perusse, Louis, Peters, Annette, Peyser, Patricia A., Porteous, David J., Posthuma, Danielle, Power, Chris, Pramstaller, Peter P., Province, Michael A., Qi, Qibin, Qu, Jia, Rader, Daniel J., Raitakari, Olli T., Ralhan, Sarju, Rallidis, Loukianos S., Rao, Dabeeru C., Redline, Susan, Reilly, Dermot F., Reiner, Alexander P., Rhee, Sang Youl, Ridker, Paul M., Rienstra, Michiel, Ripatti, Samuli, Ritchie, Marylyn D., Roden, Dan M., Rosendaal, Frits R., Rotter, Jerome I., Rudan, Igor, Rutters, Femke, Sabanayagam, Charumathi, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sanghera, Dharambir K., Sattar, Naveed, Schmidt, Börge, Schmidt, Helena, Schmidt, Reinhold, Schulze, Matthias B., Schunkert, Heribert, Scott, Laura J., Scott, Rodney J., Sever, Peter, Shiroma, Eric J., Shoemaker, M. Benjamin, Shu, Xiao-Ou, Simonsick, Eleanor M., Sims, Mario, Singh, Jai Rup, Singleton, Andrew B., Sinner, Moritz F., Smith, J. Gustav, Snieder, Harold, Spector, Tim D., Stampfer, Meir J., Stark, Klaus J., Strachan, David P., ‘t Hart, Leen M., Tabara, Yasuharu, Tang, Hua, Tardif, Jean-Claude, Thanaraj, Thangavel A., Timpson, Nicholas J., Tönjes, Anke, Tremblay, Angelo, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Tusié-Luna, Maria-Teresa, Uitterlinden, Andre G., van Dam, Rob M., van der Harst, Pim, Van der Velde, Nathalie, van Duijn, Cornelia M., van Schoor, Natasja M., Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Völzke, Henry, Wacher-Rodarte, Niels H., Walker, Mark, Wang, Ya Xing, Wareham, Nicholas J., Watanabe, Richard M., Watkins, Hugh, Weir, David R., Werge, Thomas M., Widen, Elisabeth, Wilkens, Lynne R., Willemsen, Gonneke, Willett, Walter C., Wilson, James F., Wong, Tien-Yin, Woo, Jeong-Taek, Wright, Alan F., Wu, Jer-Yuarn, Xu, Huichun, Yajnik, Chittaranjan S., Yokota, Mitsuhiro, Yuan, Jian-Min, Zeggini, Eleftheria, Zemel, Babette S., Zheng, Wei, Zhu, Xiaofeng, Zmuda, Joseph M., Zonderman, Alan B., Zwart, John-Anker, Chasman, Daniel I., Cho, Yoon Shin, Heid, Iris M., McCarthy, Mark I., Ng, Maggie C. Y., O’Donnell, Christopher J., Rivadeneira, Fernando, Thorsteinsdottir, Unnur, Sun, Yan V., Tai, E. Shyong, Boehnke, Michael, Deloukas, Panos, Justice, Anne E., Lindgren, Cecilia M., Loos, Ruth J. F., Mohlke, Karen L., North, Kari E., Stefansson, Kari, Walters, Robin G., Winkler, Thomas W., Young, Kristin L., Loh, Po-Ru, Yang, Jian, Esko, Tõnu, Assimes, Themistocles L., Auton, Adam, Abecasis, Goncalo R., Willer, Cristen J., Locke, Adam E., Berndt, Sonja I., Lettre, Guillaume, Frayling, Timothy M., Okada, Yukinori, Wood, Andrew R., Visscher, Peter M., and Hirschhorn, Joel N.
- Abstract
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10–20% (14–24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.
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- 2022
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19. APOE alleles' association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos‐investigation of neurocognitive aging (HCHS/SOL).
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Granot‐Hershkovitz, Einat, Tarraf, Wassim, Kurniansyah, Nuzulul, Daviglus, Martha, Isasi, Carmen R., Kaplan, Robert, Lamar, Melissa, Perreira, Krista M., Wassertheil‐Smoller, Sylvia, Stickel, Ariana, Thyagarajan, Bharat, Zeng, Donglin, Fornage, Myriam, DeCarli, Charles S., González, Hector M., and Sofer, Tamar
- Abstract
Introduction: Apolipoprotein E (APOE) alleles are associated with cognitive decline, mild cognitive impairment (MCI), and Alzheimer's disease in Whites, but have weaker and inconsistent effects reported in Latinos. We hypothesized that this heterogeneity is due to ancestry‐specific genetic effects. Methods: We investigated the associations of the APOE alleles with significant cognitive decline and MCI in 4183 Latinos, stratified by six Latino backgrounds, and explored whether the proportion of continental genetic ancestry (European, African, and Amerindian) modifies these associations. Results: APOE ε4 was associated with an increased risk of significant cognitive decline (odds ratio [OR] = 1.15, P‐value = 0.03), with the strongest association in Cubans (OR = 1.46, P‐value = 0.007). APOE‐ε2 was associated with decreased risk of MCI (OR = 0.37, P‐value = 0.04) in Puerto Ricans. Amerindian genetic ancestry was found to protect from the risk conferred by APOE ε4 on significant cognitive decline. Discussion: Results suggest that APOE alleles' effects on cognitive outcomes differ across six Latino backgrounds and are modified by continental genetic ancestry. [ABSTRACT FROM AUTHOR]
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- 2021
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20. Identifying Key Determinants of Childhood Obesity: A Narrative Review of Machine Learning Studies
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LeCroy, Madison N., Kim, Ryung S., Stevens, June, Hanna, David B., and Isasi, Carmen R.
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Machine learning is a class of algorithms able to handle a large number of predictors with potentially nonlinear relationships. By applying machine learning to obesity, researchers can examine how risk factors across multiple settings (e.g.,school and home) interact to best predict childhood obesity risk. In this narrative review, we provide an overview of studies that have applied machine learning to predict childhood obesity using a combination of sociodemographic and behavioral risk factors. The objective is to summarize the key determinants of obesity identified in existing machine learning studies and highlight opportunities for future machine learning applications in the field. Of 15 peer-reviewed studies, approximately half examined early childhood (0–24 months of age) determinants. These studies identified child's weight history (e.g.,history of overweight/obesity or large increases in weight-related measures between birth and 24 months of age) and parental overweight/obesity (current or prior) as key risk factors, whereas the remaining studies indicated that social factors and physical inactivity were important in middle childhood and late childhood/adolescence. Across age groups, findings suggested that race/ethnic-specific models may be needed to accurately predict obesity from middle childhood onward. Future studies should consider using existing large data sets to take advantage of the benefits of machine learning and should collect a wider range of novel risk factors (e.g.,psychosocial and sociocultural determinants of health) to better predict childhood obesity. Ultimately, such research can aid in the development of effective obesity prevention interventions, particularly ones that address the disproportionate burden of obesity experienced by racial/ethnic minorities.
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- 2021
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21. Diet quality indices and risk of metabolic syndrome among postmenopausal women of Mexican ethnic descent in the Women’s Health Initiative Observational Study
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Santiago-Torres, Margarita, Shi, Zaixing, Tinker, Lesley F., Lampe, Johanna W., Allison, Matthew A., Barrington, Wendy, Crane, Tracy E., Garcia, David O., Hayden, Kathleen M., Isasi, Carmen R., Valdiviezo-Schlomp, Carolina I., Martin, Lisa W., and Neuhouser, Marian L.
- Abstract
The prevalence of metabolic syndrome is higher among minority populations, including individuals of Mexican ethnic descent. Whether alignment to healthy dietary patterns is associated with lower risk of metabolic syndrome in this population is largely unknown. To prospectively evaluate the associations between a prioridiet quality scores and risk of metabolic syndrome and its components among postmenopausal women of Mexican ethnic descent. A total of 334 women of Mexican ethnic descent who participated in the Women’s Health Initiative (WHI) observational study without metabolic syndrome or diabetes at baseline (1993–1998) were included. Baseline diets were scored with the Alternate Mediterranean Diet (aMED), the Dietary Approaches to Stop Hypertension (DASH), the Healthy Eating Index (HEI-2010), the Mediterranean Diet Score (MDS), and the traditional Mexican Diet (MexD) score. Multivariable linear and logistic regression models were used to test the associations between baseline diet quality and risk of metabolic syndrome and its individual components at follow-up (2012-2013). Approximately 16% of women met the criteria for metabolic syndrome at follow-up. None of the diet quality indices were associated with risk of metabolic syndrome. However, higher vs lower DASH scores were associated with lower waist circumference (85.2 vs 88.0 cm) and glucose concentrations (90.0 vs 95.1 mg/dL), and higher HDL cholesterol (62.6 vs 59.0 mg/dL), while higher vs lower HEI-2010 scores were associated with lower waist circumference (83.9 vs 88.1 cm), triglycerides (103 vs 117 mg/dL) and glucose concentrations (89.5 vs 94.4 mg/dL), and higher HDL cholesterol levels (63.9 vs 58.5 mg/dL). Diet quality was not associated with risk of metabolic syndrome in this population. However, the results suggest that alignment to DASH and HEI-2010 recommendations may be beneficial for reducing some individual components of metabolic syndrome among postmenopausal women of Mexican descent.
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- 2020
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22. Associations of sleep duration and social jetlag with cardiometabolic risk factors in the study of Latino youth
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Johnson, Dayna A., Reid, Michelle, Vu, Thanh-Huyen T., Gallo, Linda C., Daviglus, Martha L., Isasi, Carmen R., Redline, Susan, and Carnethon, Mercedes
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We investigated associations of sleep duration and social jetlag with cardiometabolic outcomes.
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- 2020
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23. Food Insecurity Among Hispanic/Latino Youth: Who Is at Risk and What Are the Health Correlates?
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Potochnick, Stephanie, Perreira, Krista M., Bravin, Julia I., Castañeda, Sheila F., Daviglus, Martha L., Gallo, Linda C., and Isasi, Carmen R.
- Abstract
We examined the correlates and health implications of household food insecurity among Hispanic/Latino youth (aged 8–16 years), a high food insecurity–risk population. Using the Hispanic Community Children's Health/Study of Latino Youth (n = 1,362) and bivariate and multivariate analyses, we examined the correlates of household and child food insecurity and very low food security. We assessed the influence of four sets of risk/protective factors—child demographic, acculturation, socioeconomic, and family/social support. We then examined associations between food insecurity and four health indicators—body mass index, diet quality, depression, and anxiety—and used modification effects to assess whether these associations differed by sex, age, household income, parent nativity, and acculturative stress levels. We found high rates of food insecurity: 42% of Hispanic/Latino youth experienced household food insecurity and 33% child food insecurity. Moreover, 10% lived in a very low food secure household. Compared with their food secure peers, Hispanic/Latino youth in food insecure households experienced greater parent/child acculturative and economic stress and weakened family support systems. Associations of food insecurity with health outcomes varied by sex, age, household income, parent nativity, and child acculturative stress levels. Food insecurity is highly prevalent among Hispanic/Latino youth and has detrimental health implications, especially for girls, older youth, and youth experiencing acculturative stress. Reducing food insecurity and improving health among Hispanic/Latino youth will likely require comprehensive policies that address their multiple migration, familial, and economic stressors. [ABSTRACT FROM AUTHOR]
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- 2019
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24. Cardiovascular health and resilience to cognitive decline and impairment among diverse Hispanics/Latinos: Results from the Study of Latinos‐ Investigation of Neurocognitive Aging (SOL‐INCA).
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Tarraf, Wassim, Stickel, Ariana M, Wu, Benson, Brewer, James B., Gallo, Linda C, Talavera, Gregory A, Isasi, Carmen R, Kaplan, Robert, Lipton, Richard B., Daviglus, Martha L, Zeng, Donglin, Pike, James R., Schneiderman, Neil, Rundek, Tatjana, Sofer, Tamar, Fornage, Myriam, DeCarli, Charles S., Fletcher, Evan, Branch, Craig, and Zhou, Xiaohong
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Background: Cardiovascular disease contributes to cognitive impairment and dementia, particularly among populations facing health disparities. However, the long‐term effects of cardiovascular health on later cognitive health have not been examined among Hispanics/Latinos. Therefore, we examined relationships between cardiovascular health with change in cognition and mild cognitive impairment (MCI) among diverse Hispanics/Latinos. Method: Hispanics/Latinos (n = 6,223, ages 50‐86 years) were enrolled in the Study of Latinos ‐ Investigation of Neurocognitive Aging (SOL‐INCA), an ancillary study of the Hispanic Community Health Study/SOL (HCHS/SOL). Cardiovascular health was the primary exposure, measured using the American Heart Association's Life's Simple 7s (LS7). Outcomes of interest included 7‐year performance in cognition, change in cognition, and MCI prevalence. Cognitive outcomes included measures of learning and memory, verbal fluency, executive functioning and processing speed, and a global composite (average of the z‐scores on each test). Survey linear regressions were used to separately model the associations between LS7 with outcomes of interest, controlling for age, age2, education, language preference, Hispanic/Latino background, and income. Results: Better cardiovascular health (higher LS7 Score) was associated with higher global cognitive performance (βGlobal = 0.028 [SE = 0.005], p<0.001). These associations were evident in learning (βB‐SEVLT‐Sum = 0.024 [SE = 0.007], p<0.01), memory (β = 0.024B‐SEVLT‐Recall [SE = 0.008], p<0.01), verbal fluency (β = 0.039WF [SE = 0.008], p<0.001), executive functioning and processing speed (βDSS = 0.027 [SE = 0.007], p<0.001 and βTrails A = ‐0.022 [SE = 0.007], p<0.01). We also observed significant associations between better cardiovascular health and improved global cognitive change (β = 0.023 [SE = 0.008], p<0.01), evident also for learning (βB‐SEVLT‐Sum = 0.017 [SE = 0.008], p<0.05), executive functioning and processing speed (βDSS = 0.034 [SE = 0.008], p<0.001). Lastly, better cardiovascular health decreased the odds ratios for prevalent MCI (ORMCI = 0.90 [0.842, 0.959], p<0.01). Conclusion: Cardiovascular health was protective of 7‐year cognitive aging and associated with reduced MCI prevalence. Our findings suggest that cardiovascular health may improve resilience to cognitive decline and impairment amongst diverse Hispanics/Latinos, which could prove instrumental in public health efforts for reducing dementia disparities facing Hispanics/Latinos. [ABSTRACT FROM AUTHOR]
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- 2022
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25. Connections between reproductive health and cognitive aging among women enrolled in the HCHS/SOL and SOL‐INCA.
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Stickel, Ariana M, Tarraf, Wassim, Wu, Benson, Sundermann, Erin E., Gallo, Linda C, Lamar, Melissa, Daviglus, Martha L, Zeng, Donglin, Thyagarajan, Bharat, Isasi, Carmen R, Lipton, Richard B., Cordero, Christina, Perreira, Krista M, González, Hector M, and Banks, Sarah J
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Background: Lifetime risk for Alzheimer's disease is higher among women than men, and reproductive health factors may contribute to differential risk. Reproductive health and cognitive aging among Hispanic women/Latinas is understudied, so we examined such relationships in the Hispanic Community Healthy Study/Study of Latinos (HCHS/SOL) and the SOL‐Investigation of Neurocognitive Aging (SOL‐INCA). Method: The sample included Hispanic/Latina post‐menopausal women (n = 1,903, baseline age 44‐74 years). Exposures included oral contraceptive use, number of live births (parity), number of pregnancies, age at menarche, age at menopause, and reproductive span (years with menses). Outcomes included visit 2 cognitive performance (7‐years after baseline on average), 7‐year cognitive change (reliable change index), and NIA‐AA criteria mild cognitive impairment (MCI) prevalence. Cognitive measures included verbal learning and memory, verbal fluency, executive functioning (Trail B, higher scores = worse performance), and processing speed (Digit Symbol Substitution = DSS; Trail A, higher scores = worse performance), and a global composite (average of all individual z‐scores). Survey linear regressions were used to separately model the associations between reproductive health measures and outcomes, controlling for baseline age, education, language preference, Hispanic/Latina background, field center, income, birthplace, marital status, insurance status, and body mass index. Result: Performance at visit 2: Oral contraceptive use was associated with higher global cognitive performance (β = 0.129 [SE = 0.043], p<0.01), learning (β = 0.197 [SE = 0.062], p<0.01), and processing speed (βDSS = 0.147 [SE = 0.049], p<0.01 and βTrailA = ‐0.142 [SE = 0.071], p<0.05) than non‐use. Higher parity was associated with worse executive functioning (β = 0.035 [SE = 0.017], p<0.05) and processing speed (βDSS = ‐0.054 [SE = 0.015], p<0.001). 7‐year (average) cognitive change: Oral contraceptive use, higher parity, and higher pregnancies were each protective against change in learning (β = 0.147 [SE = 0.064], β = 0.040 [SE = 0.019], and β = 0.034 [SE = 0.014], respectively; all ps<0.05). Older age at menarche was protective against change in global cognition (β = 0.045 [SE = 0.016], p<0.01), learning (β = 0.035 [SE = 0.017], p<0.05) and memory (β = 0.037 [SE = 0.017], p<0.05). MCI: No exposures were associated with MCI. Conclusion: Reproductive health was linked to later life cognition among diverse Hispanic/Latina women. Future work should examine potential hormonal (e.g., estrogen) mechanisms. Although not associated with MCI In the present study, reproductive health may be linked to MCI status as the cohort ages and more women transition to MCI or dementia. [ABSTRACT FROM AUTHOR]
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- 2022
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26. Relationships between hearing impairment with 7‐year cognition and cognitive change: Results from the Study of Latinos‐ Investigation of Neurocognitive Aging (SOL‐INCA).
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Mendoza, Alonzo, Stickel, Ariana M, Tarraf, Wassim, Kuwayama, Sayaka, Kaur, Sonya, Paredes, Alejandra Morlett, Daviglus, Martha L, Testai, Fenando D, Zeng, Donglin, Isasi, Carmen R, Baiduc, Rachael R, Dinces, Elizabeth, Lee, David J, and González, Hector M
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Background: Hearing impairment among Hispanics/Latinos has been associated with poorer cognition, potentially increasing mild cognitive impairment (MCI) and dementia risk. We aimed to examine associations between baseline hearing impairment with 1) cognition at visit 2 (7‐years later, on average), 2) 7‐year average change in cognition, and 3) mild cognitive impairment (MCI) at visit 2 among diverse Hispanics/Latinos. Method: Hispanics/Latinos (n = 6031, average baseline age 56.4‐years) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were enrolled in the SOL ‐ Investigation of Neurocognitive Aging (SOL‐INCA) ancillary study. Hearing impairment was defined as a pure tone average (500, 1,000, 2,000, 4,000 Hz) >25 dBHL in the better ear. Cognitive testing was performed at Visit 1 and again an average of 7‐years later. Tests included measures of learning and memory, verbal fluency, and executive functioning and processing speed, and global cognition (a z‐score composite from averaging each test). MCI was calculated based on NIA‐AA criteria. Survey linear regressions were used to separately model the associations between hearing impairment with outcomes of interest, controlling for age, gender, education, Hispanic/Latino background, field center, marital status, depressive symptoms, income, and Framingham cardiovascular disease risk. Result: Performance at visit 2: In fully adjusted models, hearing impairment at baseline was associated with lower scores in global cognition (B = ‐0.12; SE = 0.03; p<0.0001) evident in learning, memory and verbal fluency, but not executive function or processing speed at visit 2 (7 years later). 7‐year (average) cognitive change: Hearing impairment was associated with significant change (declines) in processing speed (B = ‐0.12; SE = 0.06; p<0.05) but not with change in global cognition or other cognitive domains. MCI: Hearing impairment was not associated with prevalent MCI. Conclusion: We found that hearing impairment was related to lower cognitive function and increased cognitive decline compared to Hispanics/Latinos with normal hearing. Hearing impairment was not associated with MCI among Hispanics/Latinos, and further longitudinal data are needed to determine if this holds as the cohort continues to age. Future studies should also examine comorbid sensory impairments and type of hearing impairments (noise induced hearing loss, conductive, sensorineural) with cognitive trajectories and MCI risk. [ABSTRACT FROM AUTHOR]
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- 2022
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27. Associations between Depression and Subjective Cognitive Decline: Results from the Study of Latinos‐Investigation of Neurocognitive Aging (SOL‐INCA) and HCHS/SOL.
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Guareña, Lesley A., Paredes, Alejandra Morlett, Tarraf, Wassim, Kuwayama, Sayaka, Zlatar, Zvinka, Stickel, Ariana M, Gonzalez‐Pardo, Roberto, Perreira, Krista M, Wassertheil‐Smoller, Sylvia, Zeng, Donglin, Gallo, Linda C, Daviglus, Martha L, Isasi, Carmen R, and González, Hector M
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Background: Many aging Hispanic/Latino persons are worried about memory loss. Prior research suggests that subjective cognitive decline (SCD) and depression, might have common pathways, and could be precursors to cognitive impairment. We examined associations between depression and domains of SCD in a large sample of diverse Hispanics/Latinos. Methods: Data included n = 6,189 (unweighted) middle‐aged and older Hispanics/Latinos (Age M = 63.4‐years, SD = 8.2; 55% female; 40.5% with more than High School education) from 6‐heritage groups participating in the Study of Latinos‐Investigation of Neurocognitive Aging (SOL‐INCA), an ancillary study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We used survey generalized linear regression to model the associations between depressive symptoms, captured at baseline (2008‐2011) with the Center for Epidemiological Studies‐Depression 10‐Item Scale (CES‐D‐10), and SCD was measured, on average 7‐years later, via the Everyday Cognition Short‐Form (ECog‐12). Results: Higher depressive symptoms at baseline were linked to worse global (B =.37, SE =.02) and domain specific SCD [Memory (B =.34, SE =.02), Visual Spatial Planning (B =.28, SE =.02), Executive (B =.33, SE =.02)] (ps<0.001) after adjusting for cardiovascular risk and demographic covariates. These associations were more pronounced in individuals who were concerned about their attention, concentration or memory. Hispanic/Latino background (i.e., Dominican, Central American, Cuban, Mexican, Puerto‐Rican, South American, Other) did not modify the associations between depression symptoms and measures of SCD (ps>0.05). Conclusion: Elevated depressive symptoms were consistently linked to global and domain specific subjective cognitive decline across Hispanics/Latinos of diverse heritages, particularly in the presence of attention, concentration or memory concerns. Our findings underscore the importance of assessing depression when evaluating Hispanics/Latinos with cognitive complaints. [ABSTRACT FROM AUTHOR]
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- 2022
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28. Normative data for the Digit Symbol Substitution Test for diverse Hispanic/Latino adults: Results from the Study of Latinos‐Investigation of Neurocognitive Aging (SOL‐INCA).
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Paredes, Alejandra Morlett, Tarraf, Wassim, Gonzalez, Kevin A, Stickel, Ariana M, Graves, Lisa V., Salmon, David P., Kaur, Sonya, Gallo, Linda C, Isasi, Carmen R, Lipton, Richard B., Lamar, Melissa, Goodman, Zachary T, Zeng, Donglin, Garcia, Tanya P, and González, Hector M
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Background: Neuropsychological assessment plays an important role in identifying mild cognitive impairment and dementia; demographically appropriate norms are essential for interpreting test performance and maximizing diagnostic accuracy. Limited availability of normative data for cognitive tests administered to older Hispanic/Latino adults can lead to diagnostic error. Executive functioning and information processing speed are crucial elements of neuropsychological assessment. To meet the needs of the Hispanic/Latino population, we investigated the associations of age, education, ethnic background, gender, and language on the Digit Symbol Substitution (DSS) test – a subtest of the WAIS‐R – and to provide demographically adjusted norms for a diverse group of Hispanics/Latinos. Method: The target population for the Study of Latinos‐Investigation of Neurocognitive Aging (SOL‐INCA; 2015–2018) included individuals from Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American backgrounds (n = 6,172). Average age was 63.4±8.3 years, 54.5% were female, and mean education was 11.0±4.6 years. The DSS was administered as part of a larger cognitive protocol in participants' preferred language (English or Spanish). Lower scores on the DSS are associated with slower processing speed. Demographic adjusted DSS scores, and percentile cut‐points were created using survey‐adjusted regression and quantile regression models. Result: In covaried regression models, each year increase in age was associated with B = ‐0.54 (p<0.001) units decrease in DSS scores, and each additional year of education with B = 1.42 (p<0.001) units increase in performance. Males had, on average, lower DSS scores than females (B = ‐2.41; p<0.001), and individuals with English as their preferred language performed better than those preferring Spanish (B = 6.18; p<0.001). DSS performance varied significantly by Hispanic/Latino background with, predominantly, Mexicans scoring highest and Dominicans lowest on the DSS. Conclusion: While other norms for Hispanic/Latino populations exist, results from this study represent the largest and only norms for Hispanic/Latinos living in the US. Representative DSS test norms for diverse groups of US‐based Hispanics/Latinos will advance cognitive assessment and the accuracy of neurocognitive disorder diagnosis in this country. We have developed an online dashboard to facilitate potential clinical use and interpretation (https://solincalab.shinyapps.io/DSST/) [ABSTRACT FROM AUTHOR]
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- 2022
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29. Accuracy of Self-reported Weight in Hispanic/Latino Adults of the Hispanic Community Health Study/Study of Latinos.
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Fernández-Rhodes, Lindsay, Robinson, Whitney R., Sotres-Alvarez, Daniela, Franceschini, Nora, Castañeda, Sheila F., Buelna, Christina, Moncrieft, Ashley, Llabre, Maria, Daviglus, Martha L., Qibin Qi, Agarwal, Anita, Isasi, Carmen R., Smokowski, Paul, Gordon-Larsen, Penny, Northa, Kari E., Qi, Qibin, and North, Kari E
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AGE distribution ,BODY weight ,HISPANIC Americans ,IMMIGRANTS ,MULTIVARIATE analysis ,OBESITY ,RESEARCH funding ,SELF-evaluation ,SEX distribution ,DISEASE prevalence ,STANDARDS - Abstract
Background: Previous US population-based studies have found that body weight may be underestimated when self-reported. However, this research may not apply to all US Hispanics/Latinos, many of whom are immigrants with distinct cultural orientations to ideal body size. We assessed the data quality and accuracy of self-reported weight in a diverse, community-based, US sample of primarily foreign-born Hispanic/Latino adults.Methods: Using baseline data (2008-2011) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we described the difference between contemporaneous self-reported and measured current body weight (n = 16,119) and used multivariate adjusted models to establish whether the observed trends in misreporting in potential predictors of inaccuracy persisted after adjustment for other predictors. Last, we described the weighted percentage agreement in body mass classification using either self-reported or measured weight (n = 16,110).Results: Self-reported weight was well correlated with (r = 0.95) and on average 0.23 kg greater than measured weight. The range of this misreporting was large and several factors were associated with misreporting: age group, gender, body mass categories, nativity, study site by background, unit of self-report (kg or lb), and end-digit preference. The percentage agreement of body mass classification using self-reported versus measured weight was 86% and varied across prevalent health conditions.Conclusions: The direction of misreporting in self-reported weight, and thus the anticipated bias in obesity prevalence estimates based on self-reported weights, may differ in US Hispanic/Latinos from that found in prior studies. Future investigations using self-reported body weight in US Hispanic/Latinos should consider this information for bias analyses.See video abstract at, http://links.lww.com/EDE/B276. [ABSTRACT FROM AUTHOR]- Published
- 2017
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30. Socioeconomic Adversity, Social Resources, and Allostatic Load Among Hispanic/Latino Youth: The Study of Latino Youth
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Gallo, Linda C., Roesch, Scott C., Bravin, Julia I., Savin, Kimberly L., Perreira, Krista M., Carnethon, Mercedes R., Delamater, Alan M., Salazar, Christian R., Lopez-Gurrola, Maria, and Isasi, Carmen R.
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Supplemental digital content is available in the text.
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- 2019
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31. Associations of Insulin Resistance and Glycemia With Liver Enzymes in Hispanic/Latino Youths
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Parrinello, Christina M., Rudolph, Bryan J., Lazo, Mariana, Gallo, Linda C., Thyagarajan, Bharat, Cotler, Scott J., Qi, Qibin, Seeherunvong, Tossaporn, Vidot, Denise C., Strickler, Howard D., Kaplan, Robert C., and Isasi, Carmen R.
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Supplemental Digital Content is available in the text.
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- 2019
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32. The cross-sectional association of cognitive stimulation factors and cognitive function among Latino adults in Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
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Vásquez, Priscilla M., Tarraf, Wassim, Doza, Adit, Marquine, Maria J., Perreira, Krista M., Schneiderman, Neil, Zeng, Donglin, Cai, Jianwen, Isasi, Carmen R., Daviglus, Martha L., and González, Hector M.
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Higher cognitive stimulation (CS) is associated with improved cognition. Sources of CS among Hispanics/Latinos are understudied.
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- 2019
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33. Unheard, unseen and unprotected: DOHaD council’s call for action to protect the younger generation from the long-term effects of COVID-19
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Roseboom, Tessa J., Ozanne, Susan E., Godfrey, Keith M., Isasi, Carmen R., Itoh, Hiroaki, Simmons, Rebecca, Bansal, Amita, Barker, Mary, Plosch, Torsten, Sloboda, Deb M., Matthews, Stephen G., Fall, Caroline H. D., Poston, Lucilla, and Hanson, Mark A.
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- 2021
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34. Objectively Measured Sedentary Behavior, Physical Activity, and Cardiometabolic Risk in Hispanic Youth: Hispanic Community Health Study/Study of Latino Youth.
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Strizich, Garrett, Kaplan, Robert C, Sotres-Alvarez, Daniela, Diaz, Keith M, Daigre, Amber L, Carnethon, Mercedes R, Vidot, Denise C, Delamater, Alan M, Perez, Lilian, Perreira, Krista, Isasi, Carmen R, and Qi, Qibin
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Time spent in moderate-to-vigorous physical activity (MVPA), but not in sedentary behavior (SB), is related to cardiometabolic risk among non-Hispanic white youth.
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- 2018
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35. PCORnet Antibiotics and Childhood Growth Study: Process for Cohort Creation and Cohort Description
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Block, Jason P., Bailey, L. Charles, Gillman, Matthew W., Lunsford, Douglas, Boone-Heinonen, Janne, Cleveland, Lauren P., Finkelstein, Jonathan, Horgan, Casie E., Jay, Melanie, Reynolds, Juliane S., Sturtevant, Jessica L., Forrest, Christopher B., Adams, William, Appelhans, Brad, Brickman, Andrew, Bian, Jiang, Daley, Matthew F., Davidson, Arthur, Dempsey, Amanda, Dugas, Lara R., Eneli, Ihuoma, Fitzpatrick, Stephanie L., Heerman, William, Horberg, Michael, Hsia, Daniel S., Ingber, Jenny, Isasi, Carmen R., Janicke, David M., Kane, Doug, Kharbanda, Elyse, Meltzer, David, Messito, Mary Jo, Nadkarni, Prakash, O'Bryan, Kevin, Peay, Holly, Puro, Jon, Ranade, Daksha, Rao, Goutham, Tirado-Ramos, Alfredo, Rayas, Maria, Razzaghi, Hanieh, Ricket, Iben M., Rosenman, Marc, Siegel, Robert M., Solomonides, Tony, Taveras, Elsie M., Taylor, Bradley, Tolia, Veeral, Willis, Zachary, VanWormer, Jeffrey, Wysocki, Tim, and Zhou, Xiaobo
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The National Patient-Centered Clinical Research Network (PCORnet) supports observational and clinical research using health care data. The PCORnet Antibiotics and Childhood Growth Study is one of PCORnet's inaugural observational studies. We sought to describe the processes used to integrate and analyze data from children across 35 participating institutions, the cohort characteristics, and prevalence of antibiotic use.
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- 2018
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36. Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association
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Benjamin, Emelia J., Virani, Salim S., Callaway, Clifton W., Chamberlain, Alanna M., Chang, Alexander R., Cheng, Susan, Chiuve, Stephanie E., Cushman, Mary, Delling, Francesca N., Deo, Rajat, de Ferranti, Sarah D., Ferguson, Jane F., Fornage, Myriam, Gillespie, Cathleen, Isasi, Carmen R., Jiménez, Monik C., Jordan, Lori Chaffin, Judd, Suzanne E., Lackland, Daniel, Lichtman, Judith H., Lisabeth, Lynda, Liu, Simin, Longenecker, Chris T., Lutsey, Pamela L., Mackey, Jason S., Matchar, David B., Matsushita, Kunihiro, Mussolino, Michael E., Nasir, Khurram, O’Flaherty, Martin, Palaniappan, Latha P., Pandey, Ambarish, Pandey, Dilip K., Reeves, Mathew J., Ritchey, Matthew D., Rodriguez, Carlos J., Roth, Gregory A., Rosamond, Wayne D., Sampson, Uchechukwu K.A., Satou, Gary M., Shah, Svati H., Spartano, Nicole L., Tirschwell, David L., Tsao, Connie W., Voeks, Jenifer H., Willey, Joshua Z., Wilkins, John T., Wu, Jason HY., Alger, Heather M., Wong, Sally S., and Muntner, Paul
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- 2018
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37. Childhood and Adolescent Adversity and Cardiometabolic Outcomes: A Scientific Statement From the American Heart Association
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Suglia, Shakira F., Koenen, Karestan C., Boynton-Jarrett, Renée, Chan, Paul S., Clark, Cari J., Danese, Andrea, Faith, Myles S., Goldstein, Benjamin I., Hayman, Laura L., Isasi, Carmen R., Pratt, Charlotte A., Slopen, Natalie, Sumner, Jennifer A., Turer, Aslan, Turer, Christy B., and Zachariah, Justin P.
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Adverse experiences in childhood and adolescence, defined as subjectively perceived threats to the safety or security of the child’s bodily integrity, family, or social structures, are known to be associated with cardiometabolic outcomes over the life course into adulthood. This American Heart Association scientific statement reviews the scientific literature on the influence of childhood adversity on cardiometabolic outcomes that constitute the greatest public health burden in the United States, including obesity, hypertension, type 2 diabetes mellitus, and cardiovascular disease. This statement also conceptually outlines pathways linking adversity to cardiometabolic health, identifies evidence gaps, and provides suggestions for future research to inform practice and policy. We note that, despite a lack of objective agreement on what subjectively qualifies as exposure to childhood adversity and a dearth of prospective studies, substantial evidence documents an association between childhood adversity and cardiometabolic outcomes across the life course. Future studies that focus on mechanisms, resiliency, and vulnerability factors would further strengthen the evidence and provide much-needed information on targets for effective interventions. Given that childhood adversities affect cardiometabolic health and multiple health domains across the life course, interventions that ameliorate these initial upstream exposures may be more appropriate than interventions remediating downstream cardiovascular disease risk factor effects later in life.
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- 2018
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38. Stress and sleep: Results from the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study
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Alcántara, Carmela, Patel, Sanjay R., Carnethon, Mercedes, Castañeda, Sheila F., Isasi, Carmen R., Davis, Sonia, Ramos, Alberto R., Arredondo, Elva, Redline, Susan, Zee, Phyllis C., and Gallo, Linda C.
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Hispanics/Latinos face specific sociocultural stressors associated with their marginalized status in the United States. While stress is known to cause poor sleep, the differential effects of the specific stressors faced by Hispanics/Latinos have not been evaluated. Using cross-sectional data from the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study, we conducted weighted generalized linear models to evaluate the associations of acculturation stress, ethnic discrimination, and chronic moderate/severe stress with self-reported sleep outcomes (insomnia symptoms, daytime sleepiness, sleep duration) in individual and aggregate models adjusted for site, socio-demographics, behavioral, and medical conditions. Participants included 5313 Hispanic/Latino adults; 43.5% ≥ age 45, 54.8% female, and 22.0% US-born. Chronic moderate/severe stress, ethnic discrimination, and acculturation stress were each positively associated with sleep. In the adjusted aggregate model, only chronic moderate/severe stress was associated with insomnia symptoms (exp(b) = 1.07 for each additional stressor, 95% CI = 1.05, 1.09). Both acculturation stress (exp(b) = 1.05 for each additional SD, 95% CI = 1.02, 1.10) and ethnic discrimination (exp(b) = 1.05 for each additional SD, 95% CI = 1.01, 1.08) were associated with daytime sleepiness. Each SD increase in ethnic discrimination related to a 16% and 13% increased prevalence of short (< 7h) (RRR = 1.16, 95% CI = 1.02, 1.31) and long sleep duration (> 9h) (RRR = 1.13, 95% CI = 1.00, 1.27), respectively. These associations were consistent across sex. Acculturation stress and ethnic discrimination are associated with poor sleep in Hispanics/Latinos. Future research should explore whether behavioral sleep interventions minimize the impact of sociocultural stressors on sleep.
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- 2017
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39. Psychosocial factors associated with changes in cognition among middle‐aged and older Hispanics/Latinos: Findings from the HCHS/SOL and the sociocultural and SOL‐Investigation of Neurocognitive Aging (SOL‐INCA) ancillary studies.
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Estrella, Mayra L, Tarraf, Wassim, Wu, Benson, Gallo, Linda C, Marquine, Maria J, Perreira, Krista M, Vasquez, Priscilla M, Isasi, Carmen R, Zeng, Donglin, Lipton, Richard B, Gonzalez, Hector M, Daviglus, Martha L, and Lamar, Melissa
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Background: Psychosocial factors including intrapersonal and interpersonal resources and social stressors are associated with changes in cognition in older non‐Hispanic whites and Blacks. Few studies have examined these associations in Hispanics/Latinos, the largest ethnic/racial group in the US, or evaluated ethnically‐based psychosocial factors that may be more relevant to this population. We examined whether psychosocial factors predict seven‐year cognitive changes among US Hispanics/Latinos. Method: Data from the parent HCHS/SOL, and Sociocultural and SOL‐Investigation of Neurocognitive Aging ancillary studies were used (n= 2,158; ages 45+). Baseline psychosocial factors included: intrapersonal factors (optimism; purpose in life), interpersonal factors (family cohesion; social network embeddedness; social support), social stressors (loneliness; subjective social status), and ethnically‐based factors (ethnic identity; familism; perceived ethnic discrimination). Outcomes were changes in individual test scores for episodic learning and memory (B‐SEVLT‐Sum and SEVLT‐Recall), word fluency (WF), and processing speed (Digit Symbol Substitution, DSS) derived using regressions adjusting for time between assessments. Survey linear regression models were used to examine the associations between each psychosocial factor (z‐scores) and 7‐year changes in cognitive outcomes adjusting for age, sex, education, income, Hispanic/Latino background, language preference, and depressive symptoms. Result: Mean age was 55.9±7.9 years; females 54% of target population. Higher (baseline) levels of familism [(βSEVLT‐Sum (SE))= ‐0.08 (0.03), P<0.05)] predicted seven‐year decline in verbal learning. Higher optimism [βSEVLT‐Recall= 0.09 (0.03), P<0.01], social support [βSEVLT‐Recall= 0.07 (0.03), P<0.05], and ethnic identity [βSEVLT‐Recall= 0.06 (0.03), P<0.05] each predicted increase in memory. Higher familism [βSEVLT‐Recall= ‐0.08 (0.03), P<0.05] and loneliness [βSEVLT‐Recall= ‐0.06 (0.03), P<0.05] each predicted decline in memory. Higher purpose in life [βWF= 0.07 (0.03), P<0.05] predicted increase in word fluency. Higher family cohesion [βDSS= ‐0.08 (0.03, P<0.01) predicted decline in processing speed. Social network embeddedness, subjective social status, and perceived ethnic discrimination were not associated with any outcome. Conclusion: Psychosocial factors differentially related to changes in cognition. Results confirm previous studies in non‐Hispanic whites on associations of optimism, purpose in life, social support, and loneliness with select cognitive tests. They also highlight that ethnic identity and familism are ethnically‐based psychosocial factors that should be considered when examining healthy cognitive aging in US Hispanics/Latinos. [ABSTRACT FROM AUTHOR]
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- 2021
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40. Links between acculturation and level and change in cognition among middle‐aged and older Hispanics/Latinos: Findings from the HCHS/SOL and SOL‐INCA.
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Stickel, Ariana M, Tarraf, Wassim, Gonzalez, Kevin A, Breton, Jordana, Keamy, Alexandra J, Morlett, Alejandra, Gallo, Linda C, Medina, Luis D, Cai, Jianwen, Pirzada, Amber, Daviglus, Martha L, Isasi, Carmen R, Kaplan, Robert, Wassertheil‐Smoller, Sylvia, Lamar, Melissa, and Gonzalez, Hector M
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Background: Hispanics/Latinos in the United States vary widely in their levels of acculturation (adoption of Anglo‐American culture) which may have implications for cognitive functioning in older age. We aimed to characterize the relationships of acculturation with cognition and cognitive change among diverse U.S. Hispanics/Latinos. Method: Selected Hispanics/Latinos (unweighted n=5,901; ages 50+ years) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were enrolled in the Study of Latinos ‐ Investigation of Neurocognitive Aging (SOL‐INCA) ancillary study. Three measures of acculturation were collected at baseline (Short Acculturation Scale for Hispanics (SASH) – Social and Language subscales (Marin et al., 1987) and MESA Acculturation score (Kandula et al., 2008). On all measures higher scores reflect greater acculturation. Cognition was measured at two time‐points, on average, 7‐years apart. Global cognition based on a composite measure from learning and memory, executive functioning, and processing speed tests at the second testing was the main outcome of interest in addition to change in global scores. Survey linear regressions were used to separately model the associations between acculturation measures (quartiles) and cognitive outcomes (z‐scores), controlling for baseline age, sex, education, Hispanic/Latino background, field center, income, marital status, and insurance status. Result: Average age of the target population was 63.3 ± 8.3(SD) years, 55% were female, 39% reported less than high school education, and 43% were currently uninsured. Adjusting for covariates, the least acculturated (lowest quartile) according to the SASH had lower global cognition compared to all other groups (all p‐values<0.01; Social subscale: b=0.10; SE=0.03, b=0.15; SE=0.03, and b=0.13; SE=0.03, for the 2nd, 3rd, and 4th quartiles respectively; Language subscale: b=0.15; SE=0.03, b=0.12; SE=0.03, and b=0.23; SE=0.03). Individuals with the lowest MESA acculturation quartile had lower global cognition relative to those with scores in the highest quartile only (b=0.13; SE=0.04; p<0.01). None of the acculturation indices were associated with global cognitive change. Associations with domain specific cognitive outcomes were largely similar in pattern. Conclusion: Acculturation may be indicative of baseline differences in cognition rather than risk for cognitive change. Alternatively, acculturation‐based distinctions in cognition may be related to differences in familiarity with testing environments or approaches to cognitive tasks. [ABSTRACT FROM AUTHOR]
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- 2021
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41. Stroke and cardiovascular disease risk exacerbate brain aging among middle‐age and older Hispanics/Latinos: Preliminary findings from the Study of Latinos‐Investigation of Neurocognitive Aging‐MRI (SOL‐INCA‐MRI)
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Stickel, Ariana M., Tarraf, Wassim, Gonzalez, Kevin A., Paredes, Alejandra Morlett, Zeng, Donglin, Cai, Jianwen, Isasi, Carmen R., Kaplan, Robert, Lipton, Richard B., Daviglus, Martha L., Testai, Fenando D., Lamar, Melissa, Gallo, Linda C., Talavera, Gregory A., Gellman, Marc D., Ramos, Alberto R., Gonzalez, Hector M., and DeCarli, Charles S.
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Background: Hispanics/Latinos have high prevalence of cardiovascular disease (CVD) risk factors which increases risk for stroke. However, the downstream impacts of CVD risk and stroke on brain structure in aging Hispanics/Latinos remains largely unknown. We compared Hispanic/Latino brain aging by CVD risk and stroke. Method: Hispanics/Latinos (nunweighted=1,156, 50‐85 years) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) underwent magnetic resonance imaging (MRI) as part of the Study of Latinos ‐ Investigation of Neurocognitive Aging‐MRI (SOL‐INCA‐MRI) ancillary study. Outcomes included global (gray matter, total brain) and regional (lobar cortices, hippocampal) brain, lateral ventricle (log‐transformed), and total white matter hyperintensity (WMH; log‐transformed) volumes residualized for total cranial volume. Ten‐year CVD risk at visit 2 (before MRI) was determined by Framingham Risk Score and recoded into three groups (Low (<10%), Medium (10‐<20%) and High (20+%)). Stroke (yes, no) was based on self‐report of ≥1 strokes or transient ischemic attacks at visit 1 and/or 2. Linear regression models tested 1) whether CVD risk or presence of stroke modified the relationship between age and MRI outcomes, and 2) whether CVD risk or stroke related brain aging differed by sex. All models adjusted for height and Hispanic/Latino background. Result: Sample was 64.3± 7.1 years old on average (nunweighted=798 women). High CVD risk was inversely associated with total brain (standardized beta β=–0.26; p<0.001), total gray (β=‐0.23; p=0.006), frontal (β = ‐0.33; p<0.001) and parietal cortical gray (β =‐0.28; p=0.002) matter volumes and positively associated with (log) lateral ventricle (β log=0.23; p=0.006) and (log) WMH (βlog =0.42; p<0.001) volumes. Stroke/TIA (nunweighted=48) showed a similar profile of associations but only the associations with (log) lateral ventricle (βlog=0.27; p=0.049) and (log) WMH (βlog=0.44; p=0.001) reached significance. Accelerated brain aging (age slope modification) through CVD risk and stroke was evident for total brain volume but less so for other MRI outcomes, and equivalently so across sexes. Conclusion: Among Hispanics/Latinos, CVD risk and stroke are associated with poorer brain health across brain MRI indicators. Additionally, CVD risk and stroke may accelerate overall brain aging for both Hispanic/Latino men and women as determined by total brain volumes. [ABSTRACT FROM AUTHOR]
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- 2021
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42. Characterizing brain structure among middle‐age and older Hispanics/Latinos in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and SOL‐Investigation of Neurocognitive Aging (SOL‐INCA): Preliminary findings.
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Stickel, Ariana M., Tarraf, Wassim, Gonzalez, Kevin A., Paredes, Alejandra Morlett, Zeng, Donglin, Cai, Jianwen, Isasi, Carmen R., Kaplan, Robert, Lipton, Richard B., Daviglus, Martha L., Testai, Fenando D., Lamar, Melissa, Gallo, Linda C., Talavera, Gregory A., Gellman, Marc D., Ramos, Alberto R., Gonzalez, Hector M., and DeCarli, Charles S.
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Background: The older Hispanic/Latino population in the U.S. is projected to grow faster than any racial/ethnic group in the country. Little is known about brain aging in this population, and we remain poorly equipped to detect and track brain changes in this population. We characterized brain aging in a sample of Hispanics/Latinos from diverse backgrounds and investigated differences by sex. Method: Nunweighted=1,389 Hispanics/Latinos (ages 39‐85 years; 66% female) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) underwent brain magnetic resonance imaging (MRI) as part of the Study of Latinos ‐ Investigation of Neurocognitive Aging MRI (SOL‐INCA MRI) ancillary study. MRI outcomes of interest included global (gray matter, total brain) and regional (lobar cortices, hippocampus) brain volumes, lateral ventricle volume, and total white matter hyperintensity (WMH) volume. All MRI measures were residualized for total cranial volume prior to calculating brain aging trajectories using linear regressions that included sex, height, and Hispanic/Latino background as terms in the model. We also tested for effect modification by sex. Result: Mean age was 60.8± 10.3 years. Age was associated with decrements in total (βtotal=‐0.66; p<0.001) and hippocampal volumes (βhippocampus=‐0.20; p<0.001) as well as incremental enlargements in lateral ventricle and WMH volumes (βlog_lateralvent=0.48; p<0.001; βlog_WMH=0.54; p<0.001). Age was also inversely linked to total brain gray matter as well as all lobar cortical gray matter volumes. Age‐related decrements in total and regional brain volumes, but not lateral ventricle or WMH, were exacerbated in men relative to women (all p<0.05). Adjusting for height and background, women had larger total brain (standardized beta βtotal=0.27; p<0.001), frontal (βfrontal=0.27; p<0.001), and parietal (βparietal=0.17; p=0.025) volumes, smaller hippocampal and lateral ventricle volumes, and larger gray matter volumes, but did not differ in WMH as compared to men. Conclusion: These findings suggest that increasing age is associated with smaller regional MRI brain measures in Hispanic/Latino individuals. Aging patterns in gray matter volumes appeared to be exacerbated among men compared to women whereas age‐related differences in lateral ventricular volume and white matter hyperintensities were consistent between sexes. Our findings help establish the trajectories of brain aging among middle‐aged and older Hispanics/Latinos. [ABSTRACT FROM AUTHOR]
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- 2021
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43. The Association of Parental/Caregiver Chronic Stress with Youth Obesity: Findings from the Study of Latino Youth and the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study
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Isasi, Carmen R., Hua, Simin, Jung, Molly, Carnethon, Mercedes R., Perreira, Krista, Vidot, Denise C., Salazar, Christian R., McCurley, Jessica L., Sotres-Alvarez, Daniela, Van Horn, Linda, Delamater, Alan M., Llabre, Maria M., and Gallo, Linda C.
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AbstractBackground:Prior studies indicate that chronic stress is associated with obesity in adults. However, whether parental/caregiver stress is associated with obesity in their offspring has not been widely examined in Hispanic/Latino populations. In this study, we evaluated the role of caregiver chronic stress on child obesity and whether home food environment or child lifestyle behaviors explained the association.Methods:The study included a sample of Hispanic/Latino youth and their caregivers (n= 473) from the Study of Latinos (SOL) Youth study and the Hispanic Community Health Study/SOL Sociocultural Study, which enrolled children aged 8–16 years from four cities (Bronx, Chicago, Miami, and San Diego), and provided assessments of adult chronic stress. Poisson regression models were used to assess the association between parental/caregiver stress and child obesity, adjusting for potential confounders.Results:Twenty-two percent of caregivers did not report any chronic stressors, 48% reported 1–2, and 29% reported ≥3 stressors. The prevalence of obesity in youth increased with number of caregiver stressors from 23% among those without caregiver stressors to 35% among those with ≥3 stressors (pfor trend 0.03). After model adjustment, youths whose caregivers reported ≥3 stressors were more likely to be obese than youths whose caregivers reported no stressors (prevalence ratio = 1.53; 95% confidence interval 1.01–2.32). This association was independent of food home environment, child diet quality, and child physical activity, but it was not independent of caregiver obesity.Conclusions:These findings suggest that parental/caregiver chronic stress is related to obesity in their children. Future research is needed to confirm this association in longitudinal studies and in other population groups.
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- 2017
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44. Childhood Trauma and Adult Risk Factors and Disease in Hispanics/Latinos in the US: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Sociocultural Ancillary Study
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Llabre, Maria M., Schneiderman, Neil, Gallo, Linda C., Arguelles, William, Daviglus, Martha L., Gonzalez, Franklyn, Isasi, Carmen R., Perreira, Krista M., and Penedo, Frank J.
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- 2017
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45. Sex Differences in Associations of Adiposity Measures and Insulin Resistance in US Hispanic/Latino Youth: The Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth).
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Qi, Qibin, Hua, Simin, Perreira, Krista M, Cai, Jianwen, Van Horn, Linda, Schneiderman, Neil, Thyagarajan, Bharat, Delamater, Alan M, Kaplan, Robert C, and Isasi, Carmen R
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US Hispanic/Latino youth are disproportionally affected by the obesity and diabetes.
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- 2017
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46. Abstract P542: Classifying COVID-19 Related Hospitalizations and Deaths in the Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study
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Krishnaswamy, Akshaya, Ali, Tauqeer, Arynchyn, Alex, Chang, Harry, Chen, Lucas, Elkind, Mitchell, Isasi, Carmen R, Jager, Lauren, Jin, Ling, Kelly, Maureen R, Kucharska-Newton, Anna, Ortega, Victor E, Patel, Ashmi A, Reeves, Lisa, Ring, Kimberly B, Tarlton, Cheryl, Tse, Janis, Urbina, Elman, Vankineni, Maya, Morganroth, Sally E, Yang, Jihyun, Zhang, Ying, Post, Wendy S, and Oelsner, Elizabeth C
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Objectives:Administrative criteria are often used to define COVID-19 outcomes despite challenges in differentiating hospitalization “for” vs “with” COVID-19 and unknown reliability for identifying COVID-related cardiopulmonary complications. We implemented a protocol to adjudicate COVID-related events across 14 studies participating in C4R.Methods:C4R cohorts ascertained COVID-related hospitalizations and deaths via questionnaires or ongoing surveillance. Medical records were reviewed by C4R physicians using a standardized protocol to assign COVID-related diagnoses as definite or probable. C4R diagnoses were compared against ICD codes assigned to the events. This report includes data from events centrally adjudicated by C4R as of September 2022.Results:Among 144 events ascertained across 7 cohorts as potentially COVID-related, SARS-CoV-2 infection was confirmed in 107/117 (91%) non-fatal hospitalizations and 26/27 (96%) deaths. Of confirmed infections, COVID-19 illness was diagnosed as the cause of 101/107 (94%) hospitalizations and 24/26 (92%) deaths (Table). Of non-fatal hospitalizations with infection, 72% were diagnosed with severe or critical COVID-19, 78% with COVID-associated pneumonia, and 29% with renal failure; other complications were less common. C4R review did not validate diagnoses indicated by ICD codes for 1 COVID-19 infection, 5 pneumonias, 1 stroke, and 7 renal failure cases. C4R review did identify diagnoses that were not ICD-coded for 13 infections, 31 pneumonias, 6 myocardial infarctions, 5 venous thromboses, and 21 renal failure cases.Conclusions:Protocolized medical records review by C4R confirmed COVID-19 as the cause of hospitalization or death in 87% of events ascertained as potentially COVID-related and 94% of those in which SARS-CoV-2 infection was confirmed. Both false-positive and false-negative misclassification by ICD criteria was observed. Protocolized review may be useful to identify and validate COVID-related events for epidemiologic research.
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- 2023
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47. Abstract P518: Distinctive Blood Metabolomic Profiles Between US-Born and Foreign-Born Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
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Li, Yang, Peters-Samuelson, Brandilyn, Yu, Bing, Isasi, Carmen R, Perreira, Krista, Daviglus, Martha L, Chan, Queenie M, Knight, Rob, Burk, Robert, Kaplan, Robert, Wang, Tao, and Qi, Qibin
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Introduction:US-born Hispanics have a worse cardiometabolic profile compared to foreign-born Hispanics, but the underlying mechanisms are not fully understood.Hypothesis:We hypothesize that, compared to foreign-born Hispanics, US-born Hispanics have a distinctive blood metabolomic profile, which might be related to diet/lifestyle and gut microbiota and associated with health outcomes.Methods:Serum levels of 634 metabolites were profiled in US Hispanics in the Hispanic Community Health Study/Study of Latinos (N=3941 in discovery dataset; N=2368 in replication dataset). We used multiple linear regression to identify metabolites associated with US nativity. Machine-learning algorithms were used to identify potential determinants of metabolites based on genetics, sociodemographic factors, diet, lifestyle, clinical parameters, and gut microbiota. We examined prospective associations of baseline metabolites with risk of incident diseases during a 6-year follow-up using Poisson regression.Results:We identified 158 metabolites associated with US nativity in discovery dataset (FDR<0.05), 135 of which were validated in replication dataset (87 higher and 48 lower in US born vs foreign-born). A metabolomic score showed a high discriminatory ability for US-born vs foreign-born Hispanics (AUC = 0.84 and 0.82 in discovery and replication datasets, respectively) and a dose-response relationship with longer duration of US residence. Variations of these US-nativity related metabolites were explained more by nongenetic factors, especially diet and gut microbiota, compared to those unrelated to US nativity, while variations explained by genetics between these two groups of metabolites were similar. Specifically, the US-born related metabolomic profile was characterized by lower levels of many metabolites in amino acid and xenobiotic pathways (e.g., ergothioneine, phenylpropionate, indole propionate, β-cryptoxanthin, carotene diol). These metabolites were positively associated with plant-based food intake (e.g., whole grain, fruits, vegetables) and beneficial fiber-utilizing bacteria (e.g., Eubacterium, Roseburia, Oscillibacter).Cardiometabolic and kidney function traits showed stronger overall associations with US-nativity related metabolites compared to other clinical traits (e.g., liver function, lung function). Prospective analyses showed that metabolites higher in US-born Hispanics were generally associated with higher risk of server obesity, hypertension, diabetes, chronic kidney disease and asthma, while those higher in foreign-born Hispanics were generally associated with lower risk of these diseases.Conclusion:Compared to foreign-born Hispanics, US-born Hispanics showed an unfavorable blood metabolomic profile associated with multiple chronic diseases, which might be partially related to diet and gut microbiota acculturation.
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- 2023
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48. Abstract P655: Childhood and Lifecourse Socioeconomic Position and Cardiovascular Health in Hispanic/Latino Adults of the Hispanic Community Health Study/Study of Latinos
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Filigrana, Paola, Moon, Jee-Young, Gallo, Linda C, Fernández-Rhodes, Lindsay, Perreira, Krista M, Daviglus, Martha L, Thyagarajan, Bharat, Garcia, Olga L, Cai, Jianwen, Kaplan, Robert C, Suglia, Shakira F, and Isasi, Carmen R
- Abstract
Introduction:The Hispanic/Latino population experiences extensive socioeconomic adversity across the lifespan. Yet little is known about the role of lifecourse socioeconomic position (SEP) on cardiovascular health (CVH) in this population.Hypothesis:Childhood and adulthood SEP as well as socioeconomic mobility are associated with changes in CVH over time in Hispanic/Latino adults.Methods:We used longitudinal data (N = 14,604) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a population-based cohort study conducted in four major U.S cities. We determined childhood SEP using participant-reported parental education classified as No schooling; Elementary, middle, or high school; and more than high school (HS). Adulthood SEP was determined through an index with a score ranging from 0 to 9 combining participants’ education, occupation, annual household income, and assets, and classified as low (0), middle (1-4), and high SEP (5-9). Using childhood and adulthood SEP, we classified participants into socioeconomic mobility categories (e.g., persisting low, downward, or upward mobility, etc.). Using the four-health metrics of the American Heart Association “Life’s Essential 8” (i.e., body mass index, non-HDL cholesterol, fasting blood glucose or HbA1c, and blood pressure) we built a score of ideal CVH ranging from 0 to 100. CVH was assessed at baseline and at the 6-year follow-up. Since changes in CVH over time differed by CVH at baseline, we conducted linear mixed effects models stratifying by CVH at baseline, with random intercept and slope, adjusting for age, sex, Hispanic/Latino background, study center, U.S or foreign-born, years in the U.S, as well as baseline health insurance, diet, physical activity, hours of sleep per night, smoking, alcohol consumption, and antihypertensive and cholesterol medication use.Results:8% of parents did not have any formal education, 11% of the population had low SEP in adulthood, and 37% showed upward socioeconomic mobility. Among those with low (CVH score <50) and moderate to high (CVH score 50-100) baseline CVH, there was no association between childhood SEP and CVH at baseline. However, among those with moderate to high baseline CVH, high childhood SEP was associated with greater CVH over time (Coefficient for >HS: 0.24, 95% CI: 0.00, 0.47). There was no longitudinal association among those with low baseline CVH. High adulthood SEP was associated with greater CVH at baseline for those with low (Coefficient: 2.55 95% CI: 1.25, 3.85) and moderate to high CVH (Coefficient: 1.36 95% CI: 0.09, 2.62). However, it was not associated with changes in CVH. Socioeconomic mobility was associated with greater baseline CVH as well as with improvements in CVH over time.Conclusion:Among Hispanic/Latino population with high initial CVH, high childhood SEP and socioeconomic mobility were associated with better CVH over time.
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- 2023
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49. Abstract P128: Predicting BMI Percentile in Hispanic/Latino Youth Using a Machine Learning Approach: Findings From the Hispanic Community Children’s Health Study/Study of Latino Youth
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LeCroy, Madison N, Kim, Ryung S, Hanna, David B, Perreira, Krista M, Gallo, Linda C, Llabre, Maria M, Van Horn, Linda, Daviglus, Martha L, Talavera, Gregory A, Sotres-Alvarez, Daniela, and Isasi, Carmen R
- Abstract
Introduction:Among 2-19-year-olds in the United States (US), 26.2% of Hispanic/Latino youth vs. 16.6% of non-Hispanic White youth experience obesity (body mass index [BMI] percentile ≥age- and sex-specific 95thBMI percentile). While health behaviors are important, psychological and sociocultural measures vary across racial/ethnic groups and may underpin obesity disparities. Machine learning is one statistical approach that can be used to identify determinants of obesity. However, few studies have applied these methods to childhood obesity research, with most studies only examining traditional risk factors and creating a single model across all racial/ethnic groups. Our objective was to identify key predictors of BMI percentile in Hispanic/Latino youth to help design childhood obesity interventions that reduce health disparities.Hypothesis:We hypothesized that a BMI percentile prediction model developed for Hispanic/Latino youth would identify both traditional and novel risk factors as important determinants.Methods:Hispanic/Latino 8-16-year-olds from the 4 US sites of the Hispanic Community Children’s Health Study/Study of Latino Youth (SOL Youth) were examined (n=1,466). BMI percentiles were determined via measured height and weight and CDC growth charts. A supervised machine learning approach, Least Absolute Shrinkage and Selection Operator (LASSO) regression, was used with BMI percentile as the outcome. There were 98 predictor variables examined spanning demographics; health behaviors; and environmental, psychological, and sociocultural measures. LASSO-selected variables were entered into a multivariable linear regression model to obtain effect estimates. P-values were adjusted for both multiple testing and the variable selection process and assessed with α<0.025. Models incorporated survey weights, and missing data were imputed.Results:A LASSO model with 30 variables yielded the optimum mean squared error (MSE; R2=0.37), but a 12-variable solution was selected based on MSE and parsimony. Four associations were statistically significant. Perception of being larger than the “ideal” body weight (β=8.75 [95% CI: 8.21, 12.13]), reporting disordered eating (β=12.61 [95% CI: 10.64, 14.91]), and having a parent with obesity (β=4.90 [95% CI: 3.49, 17.75]) were associated with a higher BMI percentile. Spending >$5 weekly on snacks/beverages/fast food (β=-4.62 [95% CI: -19.18, -2.09]) was associated with a lower BMI percentile.Conclusions:Psychological and parental factors predicted higher BMI percentile and greater money spent on snacks/beverages/fast food predicted lower BMI percentile among Hispanic/Latino youth in the US. Addressing Hispanic/Latino youth’s relationships with food, body weight, and parents may be important in obesity interventions. Longitudinal research is needed to clarify directionality and replicate novel findings.
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- 2023
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50. Abstract P266: Complex Patterns of Early Life Adversity Vary by Gender: Associations With Cardiometabolic Health and Pre-Heart Failure Among Hispanics/Latinos in the Midlife
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April-Sanders, Ayana K, Gallo, Linda, Lee, Un Jung, Hurwitz, Barry E, Daviglus, Martha L, Talavera, Gregory A, Shook-Sa, Bonnie, Isasi, Carmen R, and Rodriguez, Carlos J
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Background:Early life adversities (ELA) are known risk factors for cardiovascular disease, but less understood is how distinct configurations of ELA impart differential risks for cardiometabolic health and heart failure (HF) in adulthood.Objective:To determine distinct profiles of ELA and assess whether there are associations between the resultant profiles and multiple indicators of cardiometabolic disease and pre-HF among Hispanic/Latino adults.Methods:Data from the Hispanic Community Health Study/Study of Latinos SCAS and ECHO-SOL (N=1143, mean age 55.9±0.4 years, 58.2% female) were used. Latent class analysis was used to identify the optimal number of classes characterizing ELA co-occurrence overall and by gender. Prevalent pre-HF was defined as systolic dysfunction (left ventricular (LF) ejection fraction <50%/ global longitudinal strain >15%) or diastolic dysfunction (≥ Grade 1) or LV remodeling (LV mass index >115 for males, >95 for females/ relative wall thickness >0.42). Weighted multivariable logit models were used to examine associations.Results:The best fitting latent classes and characterization are shown in Figure 1. By gender, ELA profiles were associated with cardiometabolic factors. E.g., females with high adversity had greater odds of obesity than those with a low adversity (OR=2.27, 95% CI: 1.39 - 3.72). Alternatively, males experiencing household dysfunction had lower odds of high cholesterol than those with low adversity (OR=0.39, 95% CI: 0.19 - 0.80). Associations were not explained by age, childhood economic hardship, nativity, and Hispanic/Latino background. ELA profiles were not associated with pre-HF (e.g., high adversity OR=0.60, household dysfunction OR=0.75; all p>0.05).Conclusions:Distinct patterns of ELA among Hispanic/Latino adults vary by gender; females experience more complex and varied patterns of adversity. Exposure to specific patterns of ELA were associated with several cardiometabolic outcomes, but no associations were found with any measures of pre-HF.
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- 2023
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