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1. Comprehensive Genomic Characterization of Refractory Multiple Myeloma Reveals a Complex Mutational and Structural Landscape Associated with Drug Resistance

Author

Lehners, Nicola, Toprak, Umut H, Xu, Jing, Paramasivam, Nagarajan, Hübschmann, Daniel, Fröhlich, Martina, Hanafiah, Nur H Md, Mughal, Sadaf, Mai, Elias K, Jauch, Anna, Hillengass, Jens, Eils, Roland, Müller-Tidow, Carsten, Brors, Benedikt, Goldschmidt, Hartmut, Schlesner, Matthias, and Raab, Marc S

Abstract

Introduction: Despite the improvement in prognosis of multiple myeloma (MM), patients refractory to immunomodulatory agents (IMiDs) and proteasome inhibitors (PIs) still experience a very poor outcome. While sequencing endeavors in recent years have comprehensively described the genetic composition of newly diagnosed and relapsed MM, the mutational landscape of refractory MM (rMM) remains elusive.

Published
2017
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