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We describe the case of a woman who came to our attention for acute onset and very rapidly worsening left hemiplegia, vision loss and cognitive impairment. MRI, laboratory and clinical investigations were highly suggestive of an active inflammatory demyelinating disease. Following exclusion of other possible etiologies, a diagnosis of Marburg's variant multiple sclerosis was made. After repeated high-dose steroids and plasma-exchange, the patient was treated with a first course of alemtuzumab followed by improvement of the clinical and MRI picture. This is the first reported case of Marburg type multiple sclerosis treated with alemtuzumab.

Additive manufacturing of large scale parts is an innovative, challenging research field, with the potential of producing parts with complex structures, specific functional and structural properties. In this study, binder jetting was employed using two different large scale printers to fabricate non-structural parts made of artificial stone. The printing bed was comprised of aggregates (River sand and Poraver expanded glass) and reactive magnesium oxide and potassium phosphate powders, which were activated by selectively depositing water, layer after layer. The exothermic reaction between reactive powders and water generates in situa hydraulic inorganic binder, that binds the aggregates in the bed. The reaction parameters were controlled to achieve a fast setting, enabling rapid printing at the macro-scale (in the range of tens of centimeters or meters). The influence of the voxel size of the printers on the microstructure and printing quality of the fabricated parts, their physical and mechanical properties as well as the in situformation of the cement phase were investigated by X-ray microtomography.