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755 results on '"Giroud P"'

1. HARMONI-ELT instrument integral field unit test tools development

Author

Navarro, Ramón, Jedamzik, Ralf, Loupias, Magali, Richard, Johan, Remillieux, Alban, Migniau, Jean-Emmanuel, Laurent, Florence, Jeanneau, Alexandre, Jarno, Aurélien, Daguisé, Eric, Girardot, Adrien, Guibert, Matthieu, Giroud, Rémi, Boudon, Didier, Bouché, Nicolas, Wasley, Dawn, Melotte, Dave, Thatte, Niranjan A., Clarke, Fraser, and Tecza, Matthias

Published
2024
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3. The Blue Multi Unit Spectroscopic Explorer (BlueMUSE) on the VLT: science drivers and overview of instrument design (Erratum)

Author

Bryant, Julia J., Motohara, Kentaro, Vernet, Joël R. D., Richard, Johan, Giroud, Rémi, Laurent, Florence, Krajnović, Davor, Jeanneau, Alexandre, Bacon, Roland, Abreu, Manuel, Adamo, Angela, Araujo, Ricardo, Bouché, Nicolas, Brinchmann, Jarle, Cai, Zhemin, Castro, Norberto, Calcines, Ariadna, Chapuis, Diane, Claeyssens, Adélaïde, Cortese, Luca, Daddi, Emanuele, Davison, Christopher, Goodwin, Michael, Harris, Robert, Hayes, Matthew, Jauzac, Mathilde, Kelz, Andreas, Kneib, Jean-Paul, Lanotte, Audrey A., Lawrence, Jonathon, Le Bouteillier, Vianney, Lebreton, Remy, Lehnert, Matthew, Lopez Sanchez, Angel, McGregor, Helen, McLeod, Anna F., Monteiro, Manuel, Morris, Simon, Opitom, Cyrielle, Pécontal, Arlette, Roth, Martin M., Robertson, David, van de Sande, Jesse, Smith, Russell, Steinmetz, Matthias, Swinbank, Mark, Urrutia, Tanya, Verhamme, Anne, Weilbacher, Peter M., Wendt, Martin, Wildi, François, and Zheng, Jessica

Published
2024
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5. 4MOST low-resolution spectrographs AIT at AIP

Author

Bryant, Julia J., Motohara, Kentaro, Vernet, Joël R. D., Laurent, Florence, Boudon, Didier, Daguisé, Eric, Disseau, Karen, Frey, Steffen, Giroud, Rémi, Jarno, Aurélien, Krogager, Jens-Kristian, Migniau, Jean-Emmanuel, Lehnert, Matthew, Pecontal, Arlette, Pécontal, Emmanuel, Remillieux, Alban, Richard, Johan, Roje, Pasko, Rodriguez Alvarez, Carlos E., and Sobiella, Deborah

Published
2024
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7. Climate Change and Stroke: A Topical Narrative Review

Author

Ranta, Anna, Kang, Janice, Saad, Ali, Wasay, Mohammed, Béjot, Yannick, Ozturk, Serefnur, Giroud, Maurice, Reis, Jacques, and Douwes, Jeroen

Abstract

The impacts of accumulating atmospheric greenhouse gases on the earth’s climate are now well established. As a result, there have been increases in ambient temperatures and resultant higher frequency and duration of temperature extremes and other extreme weather events, which have been linked to a wide range of adverse health outcomes. This topical narrative review provides a summary of published evidence on the links between climate change and stroke. There is consistent evidence of associations between stroke incidence and mortality and increasing ambient temperature and air pollution. Associations have also been shown for changes in barometric pressure, wildfires, and desert dust and sandstorms, but current evidence is limited. Flooding and other extreme weather events appear to primarily cause service disruption, but more direct links to stroke may emerge. Synergies between dietary changes that reduce stroke risk and may also reduce carbon footprint are being explored. We also discuss the impact on vulnerable populations, proposed pathophysiologic mechanisms, mitigation strategies, and current research priorities. In conclusion, climate change increasingly impacts the stroke community, warranting elevated attention.

Published
2024
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9. Comparative transcriptomics of the garden dormouse hypothalamus during hibernation.

Author

Haugg, Elena, Borner, Janus, Stalder, Gabrielle, Kübber‐Heiss, Anna, Giroud, Sylvain, and Herwig, Annika

Subjects
GENE expression, TRANSCRIPTOMES, HYPOTHALAMUS, HIBERNATION, SMALL molecules, BODY temperature regulation
Abstract

Torpor or heterothermy is an energy‐saving mechanism used by endotherms to overcome harsh environmental conditions. During winter, the garden dormouse (Eliomys quercinus) hibernates with multiday torpor bouts and body temperatures of a few degrees Celsius, interrupted by brief euthermic phases. This study investigates gene expression within the hypothalamus, the key brain area controlling energy balance, adding information on differential gene expression potentially relevant to orchestrate torpor. A de novo assembled transcriptome of the hypothalamus was generated from garden dormice hibernating under constant darkness without food and water at 5 °C. Samples were collected during early torpor, late torpor, and interbout arousal. During early torpor, 765 genes were differentially expressed as compared with interbout arousal. Twenty‐seven pathways were over‐represented, including pathways related to hemostasis, extracellular matrix organization, and signaling of small molecules. Only 82 genes were found to be differentially expressed between early and late torpor, and no pathways were over‐represented. During late torpor, 924 genes were differentially expressed relative to interbout arousal. Despite the high number of differentially expressed genes, only 10 pathways were over‐represented. Of these, eight were also observed to be over‐represented when comparing early torpor and interbout arousal. Our results are largely consistent with previous findings in other heterotherms. The addition of a transcriptome of a novel species may help to identify species‐specific and overarching torpor mechanisms through future species comparisons. [ABSTRACT FROM AUTHOR]

Published
2024
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12. More Than 50 Percent Reduction in LDL Cholesterol in Patients With Target LDL <70 mg/dL After a Stroke.

Author

Amarenco, Pierre, Lavallée, Philippa C., Kim, Jong S., Labreuche, Julien, Charles, Hugo, Giroud, Maurice, Lee, Byung-Chul, Mahagne, Marie-Hélène, Meseguer, Elena, Nighoghossian, Norbert, Steg, Philippe Gabriel, Vicaut, Éric, Bruckert, Eric, Kim, Jong S, Touboul, Pierre-Jean, Leys, Didier, Béjot, Yannick, Pico, Fernando, Touzé, Emmanuel, and Ducrocq, Gregory

Published
2023
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13. Près de la moitié des personnes vivant avec un diabète de type 1 atteignent les objectifs internationaux de glucose 6 mois après l’initiation d’une boucle fermée hybride hors hôpital : résultats du CIRDIA

Author

Picard, S., Personeni, E., Dupont, J., Amiot-Chapoutot, F., Lecornet-Sokol, E., Courbebaisse, B., Bouché, C., Giroud, F., Lablanche, S., and Borot, S.

Abstract

L’initiation des boucles fermées hybrides (BFH) est habituellement hospitalière. Le CIRDIA est un centre initiateur multisites à prédominance libérale destiné à augmenter l’offre de soins en toute sécurité, sur la base de la prise de position SFD avec DIU d’insulinothérapie automatisée exigé pour les prescripteurs. Nous rapportons nos résultats en vie réelle.

Published
2024
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14. Progress with applications of three-ion ICRF scenarios for fusion research: A review

Author

Kazakov, Ye. O., Ongena, J., Nocente, M., Bobkov, V., Garcia, J., Kiptily, V. G., Schneider, M., Wukitch, S., Wright, J. C., Dreval, M., Kirov, K. K., Mazzi, S., Ochoukov, R., Sharapov, S. E., Štancar, Ž., Weisen, H., Baranov, Y., Baruzzo, M., Bierwage, A., Bilato, R., Chomiczewska, A., Coelho, R., Craciunescu, T., Crombé, K., Delabie, E., Luna, E. de la, Dumont, R., Dumortier, P., Durodié, F., Eriksson, J., Fitzgerald, M., Galdon-Quiroga, J., Gallart, D., Garcia-Munoz, M., Giacomelli, L., Giroud, C., Gonzalez-Martin, J., Hakola, A., Henriques, R., Jacquet, P., Jepu, I., Johnson, T., Kappatou, A., Keeling, D., King, D., Klepper, C., Lauber, Ph., Lennholm, M., Lerche, E., Lomanowski, B., Lowry, C., Mantsinen, M. J., Maslov, M., Menmuir, S., Monakhov, I., Nabais, F., Nave, M. F. F., Noble, C., Panontin, E., Pinches, S. D., Polevoi, A. R., Rigamonti, D., Sahlberg, A., Salewski, M., Schneider, P. A., Sheikh, H., Shinohara, K., Siren, P., Sumida, S., Thorman, A., Tinguely, R. A., Valcarcel, D., Van Eester, D., Schoor, M. Van, Varje, J., Weiland, M., and Wendler, N.

Published
2023
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15. More Than 50 Percent Reduction in LDL Cholesterol in Patients With Target LDL <70 mg/dL After a Stroke

Author

Amarenco, Pierre, Lavallée, Philippa C., Kim, Jong S., Labreuche, Julien, Charles, Hugo, Giroud, Maurice, Lee, Byung-Chul, Mahagne, Marie-Hélène, Meseguer, Elena, Nighoghossian, Norbert, Steg, Philippe Gabriel, Vicaut, Éric, Bruckert, Eric, Kim, Jong S, Touboul, Pierre-Jean, Leys, Didier, Béjot, Yannick, Pico, Fernando, Touzé, Emmanuel, Ducrocq, Gregory, Abtan, Jérémy, Varenne, Olivier, Touboul, Pierre-Jean, Kemmel, Agnes, Syana, Fausta, Ledra, Manele, Nagasara, Tharani, Ledjeroud, Mervette, Samia, Bahous, Hadia, Hafirassou, Hazare, Benyoub, Jaghouni, Ikrame El, Yelles, Nessima, Zemouri, Sofia, Ladjeroud, Mervette, Kerai, Salim, In, YunJeong, Hobeanu, Cristina, Guidoux, Celine, Cabrejo, Lucie, Lapergue, Bertrand, Sabben, Candice, Gonzalez-Valcarcel, Jaime, Rigual, Ricardo, Sirimarco, Gaia, Martin-Bechet, Anna, Viedma, Elena, Avram, Ioan, Samson, Yves, Rosso, Charlotte, Crozier, Sophie, Leder, Sara, Léger, Anne, Deltour, Sandrine, Mutlu, Gurkan, Yger, Marion, Zavanone, Chiara, Baronnet, Flore, Pires, Christine, Lapergue, Bertrand, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Bourdain, Frédéric, Lopez, Delphine, Pico, Fernando, de la Tour, Laetitia Bayon, Chadenat, Marie-Laure, Duong, Duc Long, Genty, Solène, Hirel, Catherine, Mutlu, Gurkan, Nifle, Chantal, Servan, Jérôme, Stanciu, Daniela, Sudacevschi, Veronica, Tir, Mélissa, Troussière, Anne-Cécile, Yeung, Jennifer, Zeghoudi, Anne-Céline, Tidafi-Bayou, Ikram, Lachaud, Sylvain, Cho, Tae-Hee, Mechtouff, Laura, Ritzenthaller, Thomas, Derex, Laurent, Albanesi, Carlo, Ong, Elodie, Benoit, Amandine, Berhoune, Nadia, Felix, Sandra, Esteban-Mader, Maud, Sibon, Igor, Kazadi, Annabelle, Rouanet, François, Renou, Pauline, Debruxelles, Sabrina, Poli, Mathilde, Sagnier, Sharmila, Mas, Jean-Louis, Domigo, Valérie, Lamy, Catherine, Bodiguel, Eric, Grimaud, Jérôme, Bohotin, Valentin, Obadia, Michael, Sabben, Candice, Morvan, Erwan, Rodier, Gilles, Vadot, Wilfried, Hénon, Hilde, Cordonnier, Charlotte, Dumont, Frédéric, Bodenant, Marie, Lucas, Christian, Moulin, Solène, Dequatre, Nelly, Alamowitch, Sonia, Muresan, Jean-Paul, Drouet, Thomas, Gallea, Magalie, Dalloz, Marie-Amélie, Delorme, Stephen, Yger, Marion, Béjot, Yannick, Loisel, Philippe, Bonnin, Carine, Bernigal, Virginie, Osseby, Guy Victor, Hervieu-BègueMarsac, Marie, Garnier, Pierre, Accassat, Sandrine, Epinat, Magali, Varvat, Jérôme, Marinescu, Doïna, Triquenot-Bagan, Aude, Ozkul- Wermester, Ozlem, Philippeau, Frédéric, Olaru, Angel, Vieillart, Anne, Lannuzel, Annie, Demoly, Alice, Wolff, Valérie, Diaconu, Mihaela, Bataillard, Marc, Montoro, Francisco Macian, Faugeras, Frédéric, Gimenez, Laeticia, Abdallah-Lebeau, Françoise, Timsit, Serge, Viakhireva-Dovganyuk, Irina, Tirel-Badets, Anne, Merrien, François-Mathias, Goas, Philippe, Rouhart, François, Jourdain, Aurore, Guillon, Benoit, Hérissson, Fanny, Sevin-Allouet, Mathieu, Nasr, Nathalie, Olivot, Jean-Marc, Lecluse, Alderic, Marc, Guillaume, Touzé, Emmanuel, de la Sayette, Vincent, Apoil, Marion, Lin, Li, Cogez, Julien, Guettier, Sophie, Godefroy, Olivier, Lamy, Chantal, Bugnicourt, Jean-Marc, Taurin, Grégory, Mérienne, Marc, Gere, Julien, Chessak, Anne-Marie, Habet, Tarik, Ferrier, Anna, Bourgois, Nathalie, Minier, Dominique, Caillier-Minier, Marie, Contégal- Callier, Fabienne, Vion, Philippe, Vaschalde, Yvan, Amrani, Mohammed El, Emilie, Zuber, Mathieu, Bruandet, Marie, Join- Lambert, Claire, Garcia, Pierre-Yves, Serre, Isabelle, Faucheux, Jean-Marc, Radji, Fatia, Leca-Radu, Elena, Debroucker, Thomas, Cumurcuc, Rodica, Cakmak, Serkan, Peysson, Stéphane, Ellie, Emmanuel, Bernady, Patricia, Moulin, Thierry, Montiel, Paola, Revenco, Eugeniu, Decavel, Pierre, Medeiros, Elisabeth, Bouveret, Myriam, Louchart, Pierre, Vaduva, Claudia, Couvreur, Grégory, Sartori, Eric, Carpentier, Alnajar, Levasseur, Michèle, Louchart, Pierre, Faucheux, Jean-Marc, Neau, Philippe, Vandamme, Xavier, Meresse, Isabelle, Stantescu, Bataillard, Marc, Ozsancak, Canan, Beauvais, Katell, Auzou, Pascal, Amevigbe, Joséphine, Vuillemet, Francis, Dugay-Arentz, Marie-Hélène, Carelli, Gabriela, Martinez, Mikel, Maillet-Vioud, Marcel, Escaillas, Jean-Pierre, Chapuis, Stéphane, Tardy, Jean, Manchon, Eric, Varnet, Olivier, Kim, Yong-Jae, Chang, Yoonkyung, Song, Tae-Jin, Kim, Jong Sung, Han, Jung-Hoon, Noh, Kyung Chul, Lee, Eun-Jae, Kang, Dong-Wha, Kwon, Sun Uck, Kwon, Boseoung, Park, Seongho, Lee, Dongwhane, Kwon, Hyuk Sung, Jeong, Daeun, Lee, MinHwan, Kim, Joonggoo, Lee, Hanbin, Nam, Hyo Jung, Lee, Sang Hun, Kim, Bum Joon, Cha, Jae-kwan, Kim, DaeHyun, Kim, Rae Young, Sohn, Sang Wuk, Shim, Dong-Hyun, Lee, Hyungjin, Nah, Hyun-Wook, Sung, Sang Min, Lee, Kyung Bok, Yoon Lee, Jeong, Yoon, Jee Eun, Kim, Eung-Gyu, Seo, Jung Hwa, Kim, Yong-Won, Hwang, Yangha, Park, Man Seok, Kim, Joon-Tae, Choi, Kang-Ho, Nam, Hyo Suk, Heo, Ji Hoe, Kim, Young Dae, Hwang, In Gun, Park, Hyung Jong, Kim, Kyoung Sub, Baek, Jang Hyun, Song, Dong Beom, Yoo, Joon Sang, Park, Jong-Moo, Kwon, Ohyun, Lee, Woong-Woo, Lee, Jung-Ju, Kang, Kyusik, Kim, Byung Kun, Lim, Jae-Sung, Oh, Mi Sun, Yu, Kyung-Ho, Hong, Bora, Jang, Mihoon, Jang, Seyoung, Jin, Jung Eun, Kim, Jei, Jeong, Hye Seon, Hong, Keun Sik, Park, Hong Kyun, Cho, Yong Jin, Bang, Oh Young, Seo, Woo-Keun, and Chung, Jongwon

Published
2023
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17. Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

Author

Londregan, Allyn T., Aitmakhanova, Karlygash, Bennett, James, Byrnes, Laura J., Canterbury, Daniel P., Cheng, Xiayun, Christott, Thomas, Clemens, Jennifer, Coffey, Steven B., Dias, João M., Dowling, Matthew S., Farnie, Gillian, Fedorov, Oleg, Fennell, Kimberly F., Gamble, Vicki, Gileadi, Carina, Giroud, Charline, Harris, Michael R., Hollingshead, Brett D., and Huber, Kilian

Published
2023
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18. Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

Author

Bakker, Mark K., Kanning, Jos P., Abraham, Gad, Martinsen, Amy E., Winsvold, Bendik S., Zwart, John-Anker, Bourcier, Romain, Sawada, Tomonobu, Koido, Masaru, Kamatani, Yoichiro, Morel, Sandrine, Amouyel, Philippe, Debette, Stéphanie, Bijlenga, Philippe, Berrandou, Takiy, Ganesh, Santhi K., Bouatia-Naji, Nabila, Jones, Gregory, Bown, Matthew, Rinkel, Gabriel J.E., Veldink, Jan H., Ruigrok, Ynte M., Hege Aamodt, Anne, Heidi Skogholt, Anne, Brumpton, Ben M, Willer, Cristen J, Sandset, Else C, Kristoffersen, Espen S, Ellekjær, Hanne, Heuch, Ingrid, Nielsen, Jonas B, Hagen, Knut, Hveem, Kristian, Fritsche, Lars G, Thomas, Laurent F, Pedersen, Linda M, Gabrielsen, Maiken E, Holmen, Oddgeir L, Børte, Sigrid, Zhou, Wei, Abboud, Shérine, Pandolfo, Massimo, Thijs, Vincent, Leys, Didier, Bodenant, Marie, Louillet, Fabien, Touzé, Emmanuel, Mas, Jean-Louis, Samson, Yves, Leder, Sara, Léger, Anne, Deltour, Sandrine, Crozier, Sophie, Méresse, Isabelle, Canaple, Sandrine, Godefroy, Olivier, Giroud, Maurice, Béjot, Yannick, Decavel, Pierre, Medeiros, Elizabeth, Montiel, Paola, Moulin, Thierry, Vuillier, Fabrice, Dallongeville, Jean, Metso, Antti J, Metso, Tiina, Tatlisumak, Turgut, Grond-Ginsbach, Caspar, Lichy, Christoph, Kloss, Manja, Werner, Inge, Arnold, Marie-Luise, Dos Santos, Michael, Grau, Armin, Dichgans, Martin, Thomas-Feles, Constanze, Weber, Ralf, Brandt, Tobias, Pezzini, Alessandro, De Giuli, Valeria, Caria, Filomena, Poli, Loris, Padovani, Alessandro, Bersano, Anna, Lanfranconi, Silvia, Beretta, Simone, Ferrarese, Carlo, Giacolone, Giacomo, Paolucci, Stefano, Lyrer, Philippe, Engelter, Stefan, Fluri, Felix, Hatz, Florian, Gisler, Dominique, Bonati, Leo, Gensicke, Henrik, Amort, Margareth, Markus, Hugh, Majersik, Jennifer, Worrall, Bradford, Southerland, Andrew, Cole, John, Kittner, Steven, Evangelou, Evangelos, Warren, Helen R, Gao, He, Ntritsos, Georgios, Dimou, Niki, Esko, Tonu, Mägi, Reedik, Milani, Lili, Almgren, Peter, Boutin, Thibaud, Ding, Jun, Giulianini, Franco, Holliday, Elizabeth G, Jackson, Anne U, Li-Gao, Ruifang, Lin, Wei-Yu, Luan, Jian’an, Mangino, Massimo, Oldmeadow, Christopher, Peter Prins, Bram, Qian, Yong, Sargurupremraj, Muralidharan, Shah, Nabi, Surendran, Praveen, Thériault, Sébastien, Verweij, Niek, Willems, Sara M, Zhao, Jing-Hua, Connell, John, de Mutsert, Renée, Doney, Alex SF, Farrall, Martin, Menni, Cristina, Morris, Andrew D, Noordam, Raymond, Paré, Guillaume, Poulter, Neil R, Shields, Denis C, Stanton, Alice, Thom, Simon, Abecasis, Gonçalo, Amin, Najaf, Arking, Dan E, Ayers, Kristin L, Barbieri, Caterina M, Batini, Chiara, Bis, Joshua C, Blake, Tineka, Bochud, Murielle, Boehnke, Michael, Boerwinkle, Eric, Boomsma, Dorret I, Bottinger, Erwin P, Braund, Peter S, Brumat, Marco, Campbell, Archie, Campbell, Harry, Chakravarti, Aravinda, Chambers, John C, Chauhan, Ganesh, Ciullo, Marina, Cocca, Massimiliano, Collins, Francis, Cordell, Heather J, Davies, Gail, de Borst, Martin H, de Geus, Eco J, Deary, Ian J, Deelen, Joris, Del Greco M, Fabiola, Yusuf Demirkale, Cumhur, Dörr, Marcus, Ehret, Georg B, Elosua, Roberto, Enroth, Stefan, Mesut Erzurumluoglu, A, Ferreira, Teresa, Frånberg, Mattias, Franco, Oscar H, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Goel, Anuj, Gow, Alan J, Gudnason, Vilmundur, Guo, Xiuqing, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B, Harris, Sarah E, Hartman, Catharina A, Havulinna, Aki S, Hicks, Andrew A, Hofer, Edith, Hofman, Albert, Hottenga, Jouke-Jan, Huffman, Jennifer E, Hwang, Shih-Jen, Ingelsson, Erik, James, Alan, Jansen, Rick, Jarvelin, Marjo-Riitta, Joehanes, Roby, Johansson, Åsa, Johnson, Andrew D, Joshi, Peter K, Jousilahti, Pekka, Wouter Jukema, J, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Keavney, Bernard D, Khaw, Kay-Tee, Knekt, Paul, Knight, Joanne, Kolcic, Ivana, Kooner, Jaspal S, Koskinen, Seppo, Kristiansson, Kati, Kutalik, Zoltan, Laan, Maris, Larson, Marty, Launer, Lenore J, Lehne, Benjamin, Lehtimäki, Terho, Liewald, David CM, Lin, Li, Lind, Lars, Lindgren, Cecilia M, Liu, YongMei, Loos, Ruth JF, Lopez, Lorna M, Lu, Yingchang, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamasoula, Chrysovalanto, Marrugat, Jaume, Marten, Jonathan, Milaneschi, Yuri, Morgan, Anna, Morris, Andrew P, Morrison, Alanna C, Munson, Peter J, Nalls, Mike A, Nandakumar, Priyanka, Nelson, Christopher P, Niiranen, Teemu, Nolte, Ilja M, Nutile, Teresa, Oldehinkel, Albertine J, Oostra, Ben A, O’Reilly, Paul F, Org, Elin, Padmanabhan, Sandosh, Palmas, Walter, Palotie, Aarno, Pattie, Alison, WJH Penninx, Brenda, Perola, Markus, Peters, Annette, Polasek, Ozren, Pramstaller, Peter P, Tri Nguyen, Quang, Raitakari, Olli T, Rettig, Rainer, Rice, Kenneth, Ridker, Paul M, Ried, Janina S, Riese, Harriëtte, Ripatti, Samuli, Robino, Antonietta, Rose, Lynda M, Rotter, Jerome I, Rudan, Igor, Ruggiero, Daniela, Saba, Yasaman, Sala, Cinzia F, Salomaa, Veikko, Samani, Nilesh J, Sarin, Antti-Pekka, Schmidt, Reinhold, Schmidt, Helena, Shrine, Nick, Siscovick, David, Smith, Albert V, Snieder, Harold, Sõber, Siim, Sorice, Rossella, Starr, John M, Stott, David J, Strachan, David P, Strawbridge, Rona J, Sundström, Johan, Swertz, Morris A, Taylor, Kent D, Teumer, Alexander, Tobin, Martin D, Tomaszewski, Maciej, Toniolo, Daniela, Traglia, Michela, Trompet, Stella, Tuomilehto, Jaakko, Tzourio, Christophe, Uitterlinden, André G, Vaez, Ahmad, van der Most, Peter J, van Duijn, Cornelia M, Verwoert, Germaine C, Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Vuckovic, Dragana, Watkins, Hugh, Wild, Sarah H, Willemsen, Gonneke, Wilson, James F, Wright, Alan F, Yao, Jie, Zemunik, Tatijana, Zhang, Weihua, Attia, John R, Butterworth, Adam S, Chasman, Daniel I, Conen, David, Cucca, Francesco, Danesh, John, Hayward, Caroline, Howson, Joanna MM, Laakso, Markku, Lakatta, Edward G, Langenberg, Claudia, Melander, Olle, Mook-Kanamori, Dennis O, Palmer, Colin NA, Risch, Lorenz, Scott, Robert A, Scott, Rodney J, Sever, Peter, Spector, Tim D, van der Harst, Pim, Wareham, Nicholas J, Zeggini, Eleftheria, Levy, Daniel, Munroe, Patricia B, Newton-Cheh, Christopher, Brown, Morris J, Metspalu, Andres, Psaty, Bruce M., Wain, Louise V, Elliott, Paul, Caulfield, Mark J, Gormley, Padhraig, Anttila, Verneri, Palta, Priit, Esko, Tonu, Pers, Tune H, Farh, Kai-How, Cuenca-Leon, Ester, Muona, Mikko, Furlotte, Nicholas A, Kurth, Tobias, Ingason, Andres, McMahon, George, Ligthart, Lannie, Terwindt, Gisela M, Kallela, Mikko, Freilinger, Tobias M, Ran, Caroline, Gordon, Scott G, Stam, Anine H, Steinberg, Stacy, Borck, Guntram, Koiranen, Markku, Quaye, Lydia, Adams, Hieab H H, Lehtimäki, Terho, Sarin, Antti-Pekka, Wedenoja, Juho, Hinds, David A, Buring, Julie E, Schürks, Markus, Ridker, Paul M, Gudlaug Hrafnsdottir, Maria, Stefansson, Hreinn, Ring, Susan M, Hottenga, Jouke-Jan, Penninx, Brenda W J H, Färkkilä, Markus, Artto, Ville, Kaunisto, Mari, Vepsäläinen, Salli, Malik, Rainer, Heath, Andrew C, Madden, Pamela A F, Martin, Nicholas G, Montgomery, Grant W, Kurki, Mitja I, Kals, Mart, Mägi, Reedik, Pärn, Kalle, Hämäläinen, Eija, Huang, Hailiang, Byrnes, Andrea E, Franke, Lude, Huang, Jie, Stergiakouli, Evie, Lee, Phil H, Sandor, Cynthia, Webber, Caleb, Cader, Zameel, Muller-Myhsok, Bertram, Schreiber, Stefan, Meitinger, Thomas, Eriksson, Johan G, Salomaa, Veikko, Heikkilä, Kauko, Loehrer, Elizabeth, Uitterlinden, Andre G, Hofman, Albert, van Duijn, Cornelia M, Cherkas, Lynn, Pedersen, Linda M, Stubhaug, Audun, Nielsen, Christopher S, Männikkö, Minna, Mihailov, Evelin, Milani, Lili, Göbel, Hartmut, Esserlind, Ann-Louise, Francke Christensen, Anne, Folkmann Hansen, Thomas, Werge, Thomas, Kaprio, Jaakko, Aromaa, Arpo J, Raitakari, Olli, Arfan Ikram, M, Spector, Tim, Järvelin, Marjo-Riitta, Metspalu, Andres, Kubisch, Christian, Strachan, David P, Ferrari, Michel D, Belin, Andrea C, Dichgans, Martin, Wessman, Maija, van den Maagdenberg, Arn M J M, Boomsma, Dorret I, Davey Smith, George, Stefansson, Kari, Eriksson, Nicholas, Daly, Mark J, Neale, Benjamin M, Olesen, Jes, Chasman, Daniel I, Nyholt, Dale R, Palotie, Aarno, Akiyama, Masato, Alg, Varinder S., Børte, Sigrid, Broderick, Joseph P., Brumpton, Ben M., Dauvillier, Jérôme, Desal, Hubert, Dina, Christian, Friedrich, Christoph M., Gaál-Paavola, Emília I., Gentric, Jean-Christophe, Hirsch, Sven, Hostettler, Isabel C., Houlden, Henry, Hveem, Kristian, Jääskeläinen, Juha E., Johnsen, Marianne Bakke, Li, Liming, Lin, Kuang, Lindgren, Antti, Martin, Olivier, Matsuda, Koichi, Millwood, Iona Y., Naggara, Olivier, Niemelä, Mika, Pera, Joanna, Redon, Richard, Rouleau, Guy A., Sandvei, Marie Søfteland, Schilling, Sabine, Shotar, Eimad, Slowik, Agnieszka, Terao, Chikashi, Verschuren, W. M. Monique, Walters, Robin G., Werring, David J., Willer, Cristen J., Woo, Daniel, Worrall, Bradford B., and Zhou, Sirui

Published
2023
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20. Automédication et mésusage

Author

Bagheri, H. and Giroud, J.P.

Abstract

L’automédication est définie comme la prise d’un ou plusieurs médicaments, sur sa propre initiative sans avis médical et sans le conseil d’un pharmacien. Le médicament peut être acheté sans ordonnance en pharmacie ou être présent dans la pharmacie familiale. Les médicaments utilisés en automédication sont utilisés pour le traitement des pathologies dites « mineures » avec un profil d’effet indésirable « sécurisant » lorsqu’ils sont utilisés de manière appropriée. Néanmoins, pour nombreux de ces médicaments, les informations concernant leur efficacité et leur risque s’avèrent insuffisantes et non transparentes. Les auteurs décrivent les dangers de l’automédication et leur mésusage à travers divers exemples, comme l’utilisation des décongestionnants oraux dans le rhume pouvant générer des effets indésirables rares mais graves (effets indésirables cardiovasculaires ou neurologiques). En effet, la porosité des frontières entre les différents statuts des produits de santé facilite leur changement de statut. L’augmentation des passages du « médicament » aux produits plus faiblement réglementés, la banalisation de leur utilisation par le public et leur consommation croissante nécessitent la sensibilisation des consommateurs, mais aussi des professionnels de santé. Durant la pandémie de la COVID-19, plusieurs produits ont été commercialisés comme dispositif médical comme agent virucide (spray nasal) sans aucune efficacité. En conclusion, face à une utilisation croissante des produits (médicament, complément alimentaire, dispositif médical…) en automédication, il est nécessaire de disposer d’une base d’informations grand public, indépendantes, présentant une recommandation de médicaments validés par des experts et de garantir le maintien sur le marché des médicaments avec un rapport bénéfice/risque favorable, grâce à une pharmacovigilance active pour la détection des effets indésirables graves ou rares.

Published
2023
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21. Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4

Author

Londregan, Allyn T., Aitmakhanova, Karlygash, Bennett, James, Byrnes, Laura J., Canterbury, Daniel P., Cheng, Xiayun, Christott, Thomas, Clemens, Jennifer, Coffey, Steven B., Dias, João M., Dowling, Matthew S., Farnie, Gillian, Fedorov, Oleg, Fennell, Kimberly F., Gamble, Vicki, Gileadi, Carina, Giroud, Charline, Harris, Michael R., Hollingshead, Brett D., Huber, Kilian, Korczynska, Magdalena, Lapham, Kimberly, Loria, Paula M., Narayanan, Arjun, Owen, Dafydd R., Raux, Brigitt, Sahasrabudhe, Parag V., Ruggeri, Roger B., Sáez, Laura Díaz, Stock, Ingrid A., Thuma, Benjamin A., Tsai, Andy, and Varghese, Alison E.

Abstract

A series of small-molecule YEATS4 binders have been discovered as part of an ongoing research effort to generate high-quality probe molecules for emerging and/or challenging epigenetic targets. Analogues such as 4dand 4edemonstrate excellent potency and selectivity for YEATS4 binding versus YEATS1,2,3 and exhibit good physical properties and in vitro safety profiles. A new X-ray crystal structure confirms direct binding of this chemical series to YEATS4 at the lysine acetylation recognition site of the YEATS domain. Multiple analogues engage YEATS4 with nanomolar potency in a whole-cell nanoluciferase bioluminescent resonance energy transfer assay. Rodent pharmacokinetic studies demonstrate the competency of several analogues as in vivo-capable binders.

Published
2023
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23. The cost of research: Lasting effects of capture, surgery and muscle biopsy on brown bear (Ursus arctos) movement and physiology.

Author

Thiel, Alexandra, Hertel, Anne G., Giroud, Sylvain, Friebe, Andrea, Fuchs, Boris, Kindberg, Jonas, Græsli, Anne Randi, Arnemo, Jon M., and Evans, Alina L.

Subjects
BROWN bear, PHYSIOLOGY, BODY temperature, TRANSLATIONAL research, HIBERNATION
Abstract

Animal models are a key component of translational medicine, helping transfer scientific findings into practical applications for human health. A fundamental principle of research ethics involves weighing the benefits of the research to society against the burden imposed on the animals used for scientific purposes. The utilisation of wild animals for research requires evaluation of the effects of capture and invasive sampling. Determining the severity and duration of these interventions on the animal's physiology and behaviour allows for refining study methodology and for excluding or accounting for biased data. In this study, 39 Scandinavian brown bears (Ursus arctos) captured either while hibernating in winter or via helicopter in summer and that underwent surgery as part of a human health project had their movement, body temperature and timing of onset of hibernation compared with those of 14 control bears that had not been captured during the same period. Bears captured in winter and summer showed decreased movement from den exit until late summer, compared to those in the control group. Bears captured in summer showed reduced movement and body temperature for at least, respectively, 14 and 3 days, with an 11% decrease in hourly distance, compared to pre-capture levels, but did not differ in the timing of hibernation onset. We reveal that brown bear behaviour and physiology can be altered in response to capture and surgery for days to months, postcapture. This has broad implications for the conclusions of wildlife studies that rely upon invasive sampling. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Functional Connectome Analysis in Mild Cognitive Impairment: Comparing Alzheimer's Disease Continuum and Suspected Non-Alzheimer Pathology

Author

Brandes Lourenço, Rafael, Machado de Campos, Brunno, Rizzi, Liara, Sakzenian de Souza, Milene, Forlenza, Orestes Vicente, Giroud Joaquim, Helena, Leme Talib, Leda, Cendes, Fernando, and Figueredo Balthazar, Marcio Luiz

Abstract

Introduction:Research in brain resting-state functional connectivity (FC) analysis in mild cognitive impairment (MCI) has conflicting results. This work intends to find differences in resting-state FC of 2 groups of MCI subjects due to Alzheimer's disease (MCI-AD) continuum or to suspected non-Alzheimer pathology (MCI-SNAP).Materials and Methods:Ninety-two subjects older than 55 years were enrolled. MCI and controls were grouped using clinical dementia rating and neuropsychological data. Cerebrospinal fluid biomarkers were collected from MCI subjects, resulting in 32 MCI-AD, 25 MCI-SNAP, and 35 controls. A region of interest (ROI)-to-ROI analysis was carried out looking at inter- and intranetwork interactions selecting the following networks: default mode network (DMN), salience network (SN), visuospatial network (VN), and executive network. Pearson correlation coefficients, converted to Z-scores, were compared by T-tests with alpha set to 0.05, and false discovery rate corrected.Results:Groups were similar in age, education, and demographic measures, there were no differences in neuropsychological data between the MCI groups. The ROI-to-ROI analysis of MCI-AD versus MCI-SNAP showed no differences. MCI-AD versus controls showed decreased FC between ROIs of the SN and between ROIs from SN and VN. MCI-SNAP versus controls showed increased FC between an ROI of DMN and VN.Discussion:SN, DMN, and VN are multimodal networks with high value/high cost and may be more vulnerable to AD pathogenic processes. SN and VN were affected in the MCI-AD group, with maintained anticorrelation between DMN and VN. This may indicate subthreshold DMN dysfunction. The result in MCI-SNAP, although discrete, reflects a rearrangement of brain FC, as DMN and VN are expected to be anticorrelated. More research is necessary to confirm these findings.

Published
2022
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26. Intracranial Hemorrhage in the TST Trial.

Author

Amarenco, Pierre, Kim, Jong S., Labreuche, Julien, Charles, Hugo, Giroud, Maurice, Lavallée, Philippa C., Lee, Byung-Chul, Mahagne, Marie-Hélène, Meseguer, Elena, Nighoghossian, Norbert, Steg, Philippe Gabriel, Vicaut, Éric, Bruckert, Eric, and Treat Stroke to Target Investigators*

Published
2022
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28. Better speech-in-noise comprehension is associated with enhanced neural speech tracking in older adults with hearing impairment

Author

Schmitt, Raffael, Meyer, Martin, and Giroud, Nathalie

Abstract

The alignment between low-frequency activity in the brain and slow acoustic modulations in the speech signal depicts a core principle in present theories of speech perception—a process referred to as ‘neural speech tracking’. While most older adults, particularly those with highly prevalent age-related hearing loss, have difficulties with speech perception and comprehension, the impact of hearing loss on neural speech tracking is still unclear. In this study we investigated the effects of pure-tone hearing loss and different types of background noise on the neural tracking response in a large sample of older adults (N = 101). Furthermore, we examined whether the neural tracking response was predictive for speech comprehension. For this purpose, we obtained scalp EEG from our participants who had varying degrees of pure-tone hearing loss (7.5–59.6 dB HL for .5–8 kHz pure tones) while they listened to sentences in quiet, pink and multi-talker babble noise. Speech tracking was quantified by computing the cross-correlation between the EEG signal and the amplitude envelope of the sentences heard. A higher degree of pure-tone hearing loss was associated with greater neural speech tracking (i.e., greater cross-correlation). Additionally, neural speech tracking showed a positive association with speech comprehension. This relationship was modulated by the degree of pure-tone hearing loss with hearing-impaired participants benefitting more from greater neural speech tracking. Our results highlight the potential of neural speech tracking as an objective measure of speech comprehension and as a possible target mechanism for clinical interventions such as neurofeedback. Furthermore, the interaction between speech tracking and pure-tone hearing loss suggests a compensatory mechanism by which the hearing-impaired rely more on slow amplitude modulations in the speech signal.

Published
2022
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29. Molecular biomarkers quantified using the Single Molecule Array in Brazilian patients with mild Alzheimer's disease and mild cognitive impairment.

Author

Magalhaes, Thamires Naela Cardoso, Teixeira, Camila Vieira de Ligo, Moraes, Adriel Santos, Cassani, Ana Flavia M K C, Joaquim, Helena Passarelli Giroud, Talib, Leda Leme, Forlenza, Orestes Vicente, Balthazar, Marcio Luiz Figueredo, and Teunissen, Charlotte E.

Abstract

Background: The clinically diagnosed late‐onset Alzheimer's disease (AD) cases has the most heterogeneous pathology. The development of more sensitive biomarkers is essential to perform an early diagnosis, especially in the prodromal phase, mild cognitive impairment (MCI). Biomarkers such as glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) have emerged as potential markers of the pathophysiological process of AD. The objective of this study was to evaluate the concentrations of GFAP and NfL in blood serum and CSF of patients with MCI and mild AD in a Brazilian sample, never quantified using the Single Molecule Array technology (Simoa). Method: We used samples (blood serum and cerebrospinal fluid (CSF)) from 91 participants to perform molecular analyzes. These participants were recruited in the outpatient service of the UNICAMP Clinic Hospital. All participants underwent blood collection and only the patients, lumbar puncture, to analyze GFAP and NfL levels. All patients had pathophysiological evidence of AD (low Aβ1‐42 concentrations < 540pg/mL) and was considered Tau alteration: p‐Tau > 36.7 pg/mL and t‐Tau > 76.7 pg/mL. Result: Statistical analyzes were performed using SPSS software (version 25). We performed a multivariate analysis of covariance (MANCOVA) to compare the biomarkers levels between the groups. To compare CSF levels (Aβ42, t‐Tau, p‐Tau, GFAP and NfL) we used T‐test analyses and to correlate GFAP and NfL with CSF proteins we use partial correlations. We did not find statistical differences between the groups regarding GFAP and NfL levels, but we did find differences between Aβ1‐42 protein between MCI and mild AD (p = 0.003). We also found moderate correlations between t‐Tau, GFAP and NfL CSF levels (r =.625, p = 0.0; r =.508, p = 0.005, respectively), and p‐Tau with GFAP CSF levels (r =.373, p = 0.046). Conclusion: GFAP and NfL reflect neuro‐axonal damage and recent studies have demonstrated its effectiveness in tracking disease progression (5). Although we did not find differences between individuals in relation to GFAP and NfL markers, we were able to observe correlations between these markers at the CSF level and the proteins classically related to the pathological process of the disease. [ABSTRACT FROM AUTHOR]

Published
2023
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30. The Blue Multi Unit Spectroscopic Explorer (BlueMUSE) on the VLT: science drivers and overview of instrument design

Author

Bryant, Julia J., Motohara, Kentaro, Vernet, Joël R. D., Richard, Johan, Giroud, Rémi, Laurent, Florence, Krajnović, Davor, Jeanneau, Alexandre, Bacon, Roland, Abreu, Manuel, Adamo, Angela, Araujo, Ricardo, Bouché, Nicolas, Brinchmann, Jarle, Cai, Zhemin, Castro, Norberto, Calcines, Ariadna, Chapuis, Diane, Claeyssens, Adélaïde, Cortese, Luca, Daddi, Emanuele, Davison, Christopher, Goodwin, Michael, Harris, Robert, Hayes, Matthew, Jauzac, Mathilde, Kelz, Andreas, Kneib, Jean-Paul, Lanotte, Audrey A., Lawrence, Jon, Le Bouteillier, Vianney, Le Breton, Rémy, Lehnert, Matthew, Lopez Sanchez, Angel, McGregor, Helen, McLeod, Anna F., Monteiro, Manuel, Morris, Simon, Opitom, Cyrielle, Pécontal, Arlette, Roth, Martin M., Robertson, David, van de Sande, Jesse, Smith, Russel, Steinmetz, Matthias, Swinbank, Mark, Urrutia, Tanya, Verhamme, Anne, Weilbacher, Peter M., Wendt, Martin, Wildi, François, and Zheng, Jessica

Published
2024
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31. HARMONI at ELT: project status and instrument overview

Author

Bryant, Julia J., Motohara, Kentaro, Vernet, Joël R. D., Thatte, Niranjan A., Melotte, Dave, Neichel, Benoit, Le Mignant, David, Rees, Phil, Clarke, Fraser, Ferraro-Wood, Vanessa, Gonzalez, Oscar, Jones, Maia, Álvarez Urueña, Alonso, Argelaguet Vilaseca, Heribert, Arribas Mocoroa, Santiago, Caballero, José Antonio, Carracedo Carballal, Gonzalo José, Estrada Piqueras, Alberto, Ferro, Irene, García García, Miriam, Lamperti, Isabella, Pereira Santaella, Miguel, Perna, Michele, Piqueras Lopez, Javier, Bouché, Nicolas, Boudon, Didier, Daguise, Eric, Domenis, Nicola, Fensch, Jérémy, Olivier Flasseur, Olivier, Giroud, Rémi, Guibert, Matthieu, Jarno, Aurelien, Jeanneau, Alexandre, Krogager, Jens-Kristian, Langlois, Maud, Laurent, Florence, Loupias, Magali, Migniau, Jean-Emmanuel, Nguyen, Dieu, Piqueras, Laure, Remillieux, Alban, Richard, Johan, Pecontal, Arlette, Bardou, Lisa, Barr, David, Cetre, Sylvain, Dimoudi, Sofia, Dubbeldam, Marc, Dunn, Andrew, Gadotti, Dimitri, Guy, Joss, King, David, McLeod, Anna, Morris, Simon, Morris, Tim, O'Brien, Kieran, Ronson, Emily, Smith, Russell, Staykov, Lazar, Swinbank, Mark, Accardo, Matteo, Alvarez Mendez, Domingo, Fuerte Rodriguez, Pablo Alberto, George, Elizabeth, Ives, Derek, Mehrgan, Leander, Mueller, Eric, Reyes, Javier, Conzelmann, Ralf, Gutierrez Cheetham, Pablo, Alonso Sanchez, Angel, Battaglia, Giuseppina, Cagigas, Miguel, Castro-Almazán, Julio A., Chulani, Haresh, Delgado-García, Graciela, Fernandez Izquierdo, Patricia, Esparza-Arredondo, Donaji, García-Lorenzo, Begoña, Hernández González, Alberto, Hernández Suárez, Elvio, Licandro, Javier, Joven, Enrique, López López, Roberto, Lujan Gonzalez, Alejandro Antonio, Martín Hernando, Yolanda, Martín-Navarro, Ignacio, Mediavilla, Evencio, Menéndez Mendoza, Saúl, Montoya Martínez, Luz Maria, Peñate Castro, José, Murgas, Felipe, Pallé, Enric, Pérez, Álvaro, Rasilla, Jose Luis, Rebolo, Rafael, Rodríguez, Horacio, Rodríguez Ramos, Luis Fernando, Sánchez Béjar, Victor, Shahbaz, Tariq, Vega Moreno, Afrodisio, Viera, Teodora, Bonnefoy, Mickaël, Bret, Tony, Carlotti, Alexis, Correia, Jean-Jacques, Curaba, Stéphane, Delboulbé, Alain, Guieu, Sylvain, Hours, Adrien, Hubert, Zoltan, Jocou, Laurent, Magnard, Yves, Michaud, Laurence, Moulin, Thibaut, Pancher, Fabrice, Rabou, Patrick, Rochat, Sylvain, Stadler, Eric, Contini, Thierry, Larrieu, Marie, Mamessier, Sébastien, Boebion, Olivier, Fantei-Caujolle, Yan, Lecron, Daniel, Amram, Philippe, Blanchard, Patrick, Bon, William, Bonnefoi, Anne, Bozier, Alexandre, Ceria, William, Challita, Zalpha, Charles, Yannick, Choquet, Elodie, Costille, Anne, Delsanti, Audrey, Dohlen, Kjetil, Ducret, Franck, El Hadi, Kacem, Foulon, Benjamin, Gimenez, Jean-Luc, Groussin, Olivier, Jaquet, Marc, Renault, Edgard, Rouquette, Paul, Sanchez, Patrice, Vigan, Arthur, Zavagno, Annie, Fétick, Romain, Fusco, Thierry, Héritier, Cedric, Sauvage, Jean-Francois, Vedrenne, Nicolas, Aksoy, Demet, Caldwell, Martin, Fitzpatrick, Ann, Geddert, Carl, Hiscock, Peter, Johnson, Emma, Nalagatla, Murali, Saraff, Louise, Shreeves, Joe, Tildesley, Matthew, Wells, Mark, Aretos, Anastasios, Barrett, Lee, Black, Martin, Bond, Charlotte, Brierley, Saskia, Bryson, Ian, Calderhead, Amelia, Campbell, Kenny, Carruthers, James, Chapman, Lee, Cochrane, William, Gillespie, Rory, Harman, Joel, Harvey, Douglas, Harvey, Eamonn, Johnson, Bethany, Louth, Tom, MacIntosh, Mike, MacIver, Anna, Miller, Chris, Montgomery, David, Murali, Meenu, Murray, John, O'Malley, Norman, Sanchez-Janssen, Ruben, Schwartz, Noah, Smith, Patrick, Strachan, Jonathan, Todd, Stephen, Wasley, Dawn, Wilson, Sandi, Zhou, Junyi, Bell, Eric, Gnedin, Oleg, Gultekin, Kayhan, Mateo, Mario, Meyer, Michael, Birkby, Jayne, Boland, Liam, Cappellari, Michele, Castillo Dominguez, Edgar, Gooding, David, Grisdale, Kearn, Hidalgo, Andrea, Kariuki, James, Lewis, Ian, McCall, Kieran, Meyer, R. Elliot, Muslimov, Eduard, Lowe, Adam, Ozer, Zeynep, Paszynska, Sophie, Rigopoulou, Dimitra, Tecza, Matthias, and York, Alec

Published
2024
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32. Intracranial Hemorrhage in the TST Trial

Author

Amarenco, Pierre, Kim, Jong S., Labreuche, Julien, Charles, Hugo, Giroud, Maurice, Lavallée, Philippa C., Lee, Byung-Chul, Mahagne, Marie-Hélène, Meseguer, Elena, Nighoghossian, Norbert, Steg, Philippe Gabriel, Vicaut, Éric, and Bruckert, Eric

Abstract

Supplemental Digital Content is available in the text.

Published
2022
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33. High efficiency and clinical relevance of exome sequencing in the daily practice of neurogenetics

Author

Thomas, Quentin, Vitobello, Antonio, Tran Mau-Them, Frederic, Duffourd, Yannis, Fromont, Agnès, Giroud, Maurice, Daubail, Benoit, Jacquin-Piques, Agnès, Hervieu-Begue, Marie, Moreau, Thibault, Osseby, Guy-Victor, Garret, Philippine, Nambot, Sophie, Delanne, Julian, Bruel, Ange-Line, Sorlin, Arthur, Callier, Patrick, Denomme-Pichon, Anne-Sophie, Faivre, Laurence, Béjot, Yannick, Philippe, Christophe, Thauvin-Robinet, Christel, and Moutton, Sébastien

Abstract

ObjectiveTo assess the efficiency and relevance of clinical exome sequencing (cES) as a first-tier or second-tier test for the diagnosis of progressive neurological disorders in the daily practice of Neurology and Genetic Departments.MethodsSixty-seven probands with various progressive neurological disorders (cerebellar ataxias, neuromuscular disorders, spastic paraplegias, movement disorders and individuals with complex phenotypes labelled ‘other’) were recruited over a 4-year period regardless of their age, gender, familial history and clinical framework. Individuals could have had prior genetic tests as long as it was not cES. cES was performed in a proband-only (60/67) or trio (7/67) strategy depending on available samples and was analysed with an in-house pipeline including software for CNV and mitochondrial-DNA variant detection.ResultsIn 29/67 individuals, cES identified clearly pathogenic variants leading to a 43% positive yield. When performed as a first-tier test, cES identified pathogenic variants for 53% of individuals (10/19). Difficult cases were solved including double diagnoses within a kindred or identification of a neurodegeneration with brain iron accumulation in a patient with encephalopathy of suspected mitochondrial origin.ConclusionThis study shows that cES is a powerful tool for the daily practice of neurogenetics offering an efficient (43%) and appropriate approach for clinically and genetically complex and heterogeneous disorders.

Published
2022
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35. Stroke in women: When gender matters

Author

Thomas, Q., Crespy, V., Duloquin, G., Ndiaye, M., Sauvant, M., Béjot, Y., and Giroud, M.

Abstract

Stroke in women may be considered as a distinct entity due to numerous differences compared with men, including specific epidemiological, etiological, and outcome features along with unique pathophysiological mechanisms. Stroke is the second cause of death in women worldwide with sex-specific causes of stroke in youger women such as pregnancy, post-partum period, oral contraception and migraine. Substitutive hormone treatment in older women is no more recommended in regard of the increased thromboembolic risk it generates. Venous thrombolysis with rtPA and mechanical thrombectomy are now proven to be as efficacious in women as in men. After a stroke, women present poorer quality of life than men attributable to age, more severe stroke, pre-stroke dependency and depression. Recent data concerning the latest epidemiological surveys reveal a shift in trends with the rise of incidence of strokes in young women (≤55 years and 64 years) contrasting with the stability of incidence rates in older women. As science is unvealing sex-related differences in cardiovascular disorders, health policies need to be adapted accordingly to improve stroke prevention and pre-stroke health in women. In the meantime, therapeutical trials should include more women in order to be able to formulate adequate management.

Published
2021
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36. Determination of radial profiles of wood properties using a near infrared scanning system

Author

Giroud, Guillaume, Defo, Maurice, and Bégin, Jean

Abstract

A near infrared (NIR) spectrometer, equipped with a 2-mm diameter fiber optic probe, was used to develop a rapid and automated method for determining the radial profiles of wood properties for six tree species of the boreal forest of eastern Canada. Partial least squares regressions were performed using individual spectra, collected every 5 mm, from the pith to the bark, using 1,538 samples previously scanned by SilviScan to provide reference data. Results obtained for density (r2of 0.57 to 0.65; SE of 21 to 33 kg/m3), microfibril angle (0.56 to 0.82, 2.3 to 4.8°) and modulus of elasticity (0.71 to 0.85, 1.3 to 1.8 GPa) were suitable for the purpose of this study. This method was then applied to more than 30,000 tree cores and the resulting radial profiles of the properties were consistent with literature. Area-weighted average predictions also gave reliable estimates at the disk scale. NIR-estimated values were strongly correlated to the measured density (r of 0.83 to 0.93) and modulus of elasticity (0.82 to 0.88) and moderately correlated to measured microfibril angle (0.64 to 0.78). Radial profiles of wood properties are needed to characterize the proportions of juvenile and mature wood. The developed method therefore offers interesting opportunities for estimating the quality of wood fiber in trees growing in plantation or natural forest.

Published
2021
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37. Nomenclature for Pediatric and Congenital Cardiac Care: Unification of Clinical and Administrative Nomenclature – The 2021 International Paediatric and Congenital Cardiac Code (IPCCC) and the Eleventh Revision of the International Classification of Diseases (ICD-11)

Author

Jacobs, Jeffrey P., Franklin, Rodney C. G., Béland, Marie J., Spicer, Diane E., Colan, Steven D., Walters, Henry L., Bailliard, Frédérique, Houyel, Lucile, St. Louis, James D., Lopez, Leo, Aiello, Vera D., Gaynor, J. William, Krogmann, Otto N., Kurosawa, Hiromi, Maruszewski, Bohdan J., Stellin, Giovanni, Weinberg, Paul Morris, Jacobs, Marshall Lewis, Boris, Jeffrey R., Cohen, Meryl S., Everett, Allen D., Giroud, Jorge M., Guleserian, Kristine J., Hughes, Marina L., Juraszek, Amy L., Seslar, Stephen P., Shepard, Charles W., Srivastava, Shubhika, Cook, Andrew C., Crucean, Adrian, Hernandez, Lazaro E., Loomba, Rohit S., Rogers, Lindsay S., Sanders, Stephen P., Savla, Jill J., Tierney, Elif Seda Selamet, Tretter, Justin T., Wang, Lianyi, Elliott, Martin J., Mavroudis, Constantine, and Tchervenkov, Christo I.

Abstract

AbstractSubstantial progress has been made in the standardization of nomenclature for paediatric and congenital cardiac care. In 1936, Maude Abbott published her Atlas of Congenital Cardiac Disease, which was the first formal attempt to classify congenital heart disease. The International Paediatric and Congenital Cardiac Code(IPCCC) is now utilized worldwide and has most recently become the paediatric and congenital cardiac component of the Eleventh Revision of the International Classification of Diseases(ICD-11). The most recent publication of the IPCCCwas in 2017. This manuscript provides an updated 2021 version of the IPCCC.The International Society for Nomenclature of Paediatric and Congenital Heart Disease(ISNPCHD), in collaboration with the World Health Organization (WHO), developed the paediatric and congenital cardiac nomenclature that is now within the eleventh version of the International Classification of Diseases (ICD-11). This unification of IPCCCand ICD-11 is the IPCCC ICD-11 Nomenclatureand is the first time that the clinical nomenclature for paediatric and congenital cardiac care and the administrative nomenclature for paediatric and congenital cardiac care are harmonized. The resultant congenital cardiac component of ICD-11 was increased from 29 congenital cardiac codes in ICD-9 and 73 congenital cardiac codes in ICD-10 to 318 codes submitted by ISNPCHDthrough 2018 for incorporation into ICD-11. After these 318 terms were incorporated into ICD-11 in 2018, the WHOICD-11 team added an additional 49 terms, some of which are acceptable legacy terms from ICD-10, while others provide greater granularity than the ISNPCHDthought was originally acceptable. Thus, the total number of paediatric and congenital cardiac terms in ICD-11 is 367. In this manuscript, we describe and review the terminology, hierarchy, and definitions of the IPCCC ICD-11 Nomenclature. This article, therefore, presents a global system of nomenclature for paediatric and congenital cardiac care that unifies clinical and administrative nomenclature.The members of ISNPCHDrealize that the nomenclature published in this manuscript will continue to evolve. The version of the IPCCCthat was published in 2017 has evolved and changed, and it is now replaced by this 2021 version. In the future, ISNPCHDwill again publish updated versions of IPCCC, as IPCCCcontinues to evolve.

Published
2021
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38. Affiche et recherche historique contemporaine en Suisse. Un potentiel remarquable mais délicat.

Author

Giroud, Jean-Charles

Subjects
HISTORICAL research, COLLEGE teachers, ART historians, ART critics, SOCIAL sciences, POSTERS, INTERACTIVE art
Abstract

Ephemera are increasingly attracting the interest of academics and historians. The illustrated poster is one of them, as far as the Western 20th century is concerned. In Switzerland, despite certain eclipses, it has been the subject of public collections for more than a century and of works marked by an essentially artistic and then graphic approach, most often from critics and art historians. However, the field is much broader and is situated first and foremost in economics and social sciences, which provide the key elements for contextualizing the illustrated poster and better understanding it in its artistic and graphic dimensions. The crossing of disciplines is particularly fruitful in poster history. Whatever his speciality, the historian who approaches it must take certain precautions because this world is so complex and interactive. He must be particularly attentive to the establishment of his corpus and to the precise dating of posters, a field that is still little explored but particularly rich, given the international distinction of Switzerland in this field. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Benefit of Targeting a LDL (Low-Density Lipoprotein) Cholesterol <70 mg/dL During 5 Years After Ischemic Stroke.

Author

Amarenco, Pierre, Kim, Jong S., Labreuche, Julien, Charles, Hugo, Giroud, Maurice, Lee, Byung-Chul, Mahagne, Marie-Hélène, Nighoghossian, Norbert, Gabriel Steg, Philippe, Vicaut, Éric, Bruckert, Eric, Touboul, Pierre-Jean, Leys, Didier, Béjot, Yannick, Lavallée, Philippa, Pico, Fernando, Touzé, Emmanuel, Ducrocq, Gregory, Abtan, Jérémy, and Varenne, Olivier

Published
2020
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44. High Prevalence of Social Cognition Disorders and Mild Cognitive Impairment Long Term After Stroke.

Author

Sensenbrenner, Bénédicte, Rouaud, Olivier, Graule-Petot, Anny, Guillemin, Sophie, Piver, Ariane, Giroud, Maurice, Béjot, Yannick, and Jacquin-Piques, Agnès

Abstract

Purpose: Social cognition disorders after stroke are poorly described. Yet, rehabilitation difficulties are frequent after stroke. This study aimed to evaluate the frequency of social cognition disorders 3 years after a first-ever stroke and to assess the factors associated with this condition. The second aim was to describe all the cognitive domains altered in the same population.Methods: Patients who suffered from a first-ever ischemic or hemorrhagic stroke underwent clinical and neuropsychological assessment, which included the mini-Social cognition and Emotional Assessment (SEA) for evaluating social cognition.Results: The 43 included patients were 67±15 years old, with a median Neurological Institute of Health Stroke Scale (NIHSS) (± interquartile range) at 0±1, and a median modified Rankin Scale (± interquartile range) at 1±1. Twenty patients (46.5%) had poor results in the facial emotions subtest; this factor was associated with a low educational grade (P=0.001). Fourteen patients (34.2%) had poor results on the "faux-pas" recognition subtest; this factor was associated with nonverbal episodic memory disorders (P=0.01). Thirty four patients (79.1%) had cognitive impairment, with at least 1 cognitive domain affected.Conclusions: The study demonstrates the high frequency of social cognition impairment 3 years after the first-ever stroke in young patients. Doctors and nurses should be sensitized to cognitive handicap after stroke because of difficulties for rehabilitation and returning to work. [ABSTRACT FROM AUTHOR]

Published
2020
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45. Modelling wood density and modulus of elasticity in white spruce plantations in Eastern Québec.

Author

Tony, Franceschini, Thibaut, Ferraille, Guillaume, Giroud, Julie, Barrette, and Robert, Schneider

Subjects
MODULUS of elasticity, WHITE spruce, PLANTATIONS, WOOD quality, TREE growth, FOREST management
Abstract

Copyright of Forestry Chronicle is the property of Canadian Institute of Forestry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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46. A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor.

Author

Giroud-Gerbetant, Judith, Joffraud, Magali, Giner, Maria Pilar, Cercillieux, Angelique, Bartova, Simona, Makarov, Mikhail V., Zapata-Pérez, Rubén, Sánchez-García, José L., Houtkooper, Riekelt H., Migaud, Marie E., Moco, Sofia, and Canto, Carles

Abstract

A decay in intracellular NAD+ levels is one of the hallmarks of physiological decline in normal tissue functions. Accordingly, dietary supplementation with NAD+ precursors can prevent, alleviate, or even reverse multiple metabolic complications and age-related disorders in diverse model organisms. Within the constellation of NAD+ precursors, nicotinamide riboside (NR) has gained attention due to its potent NAD+ biosynthetic effects in vivo while lacking adverse clinical effects. Nevertheless, NR is not stable in circulation, and its utilization is rate-limited by the expression of nicotinamide riboside kinases (NRKs). Therefore, there is a strong interest in identifying new effective NAD+ precursors that can overcome these limitations. Through a combination of metabolomics and pharmacological approaches, we describe how NRH, a reduced form of NR, serves as a potent NAD+ precursor in mammalian cells and mice. NRH acts as a more potent and faster NAD+ precursor than NR in mammalian cells and tissues. Despite the minor structural difference, we found that NRH uses different steps and enzymes to synthesize NAD+, thus revealing a new NRK1-independent pathway for NAD+ synthesis. Finally, we provide evidence that NRH is orally bioavailable in mice and prevents cisplatin-induced acute kidney injury. Our data identify a new pathway for NAD+ synthesis and classify NRH as a promising new therapeutic strategy to enhance NAD+ levels. • A reduced form of nicotinamide riboside (NRH) is a potent NAD+ precursor in cultured cells and mouse tissues. • NRH leads to NAD+ synthesis through a new, independent path to that of NR. • NRH is orally bioavailable and not degraded in plasma. • NRH alleviates cisplatin-induced acute kidney injury. [ABSTRACT FROM AUTHOR]

Published
2019
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47. The potential of immersive auditory‐cognitive training as a platform for studying hearing‐loss and cognitive decline.

Author

Frei, Vanessa Laura and Giroud, Nathalie

Abstract

Background: Hearing loss (HL) is considered one of the top modifiable risk factors for cognitive decline and dementia. However, modifiability is still a challenge, with auditory‐cognitive training (ACT) representing a promising approach on top of hearing devices, although generalizability and transfer effects of such trainings remain a challenge. Method: The objective of this study is to gain insights into the benefits of an ACT in audio‐visual immersion with the goal to improve speech comprehension in older adults at‐risk for dementia. Participants (with varying degrees of cognitive capacity and pure‐tone HL) answer questions about spoken content in a three‐dimensional immersive (virtual reality and stereoscopic stimulus presentation) conversation. Electroencephalography is used to measure neural responses simultaneously. Speech comprehension is measured on a behavioral level and concurrently cortical responses to speech as a function of baseline cognitive capacity, audiometric measures and varying cognitive demand is assessed. We address the challenge of generalizability and transferability by enriching our training with natural, relatable speech content, and increased immersion simulating day‐by‐day speech situations. Result: We predict improved speech comprehension post immersive ACT and simultaneously gain a deeper understanding of the associated neural responses to speech with varying cognitive demands. We further intend to model these effects as a function of baseline cognitive capacity and degree of pure‐tone HL (data collection will start February 2022). Conclusion: The central objective is whether immersive ACT has the potential to improve speech comprehension and to what extent such benefits depend on individual cognitive capacity and pure‐tone HL in older adults at‐risk for dementia. The design allows for both a within‐ and a between‐person perspective, whereby individual prerequisites, environmental and motivational factors will be considered. Finally, it allows for valuable considerations for future trainings, particularly regarding transferability and generalizability, while enabling increased engagement of individuals. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Speech processing in the brain at risk for dementia.

Author

Bolt, Elena and Giroud, Nathalie

Abstract

Background: Given the close relationship between hearing and cognitive function in older age, characterization of speech processing deficits along the auditory pathway is of great importance for the brain at risk of dementia. In the ascending, primary auditory pathway, signals pass through subcortical relay stations in the brainstem and midbrain before being integrated into cortical areas. A recent study suggests that the pathophysiology of MCI extends to speech encoding in the brainstem and that both cortical and subcortical markers of speech processing have predictive potential for putative Mild Cognitive Impairment (MCI). In this project, we are testing these neural speech processing markers to see if they can distinguish healthy older adults with age‐related hearing loss from those at risk for dementia. Methods: Electroencephalography (EEG, 32 channels, sampling rate = 16 384 Hz) will be recorded from N = 40 older participants (age ≥ 60 years, retired) while listening to excerpts from an audiobook. We use a novel EEG paradigm that allows us to simultaneously measure cortical and subcortical responses to natural running speech. Based on their Montreal Cognitive Assessment (MoCA) score, participants are divided into an experimental group with "putative MCI" (MoCA < 26) and a control group (MoCA ≥ 26). In addition, we perform audiometric testing with pure tones (PTA) and speech‐in‐noise (SiN) tests to assess participants' hearing function. Results: We are currently in the middle of data collection and will be able to present preliminary results at AAIC. We expect to see altered speech processing in the experimental group, particularly driven by slower and weaker encoding at the subcortical level. In a next step, we aim to use the neural markers of speech processing that emerge from this framework as features for a diagnostic model that predicts MCI using a binary classifier, considering the hearing status of the participants. Conclusion: The main goal of this study is to investigate neural markers of speech processing for their differential diagnostic potential for the brain at risk for dementia. Depending on the results, such neurophysiological markers could prove useful for early diagnosis in the clinic in the longer term. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Determination of radial profiles of wood properties using a near infrared scanning system

Author

Giroud, Guillaume, Defo, Maurice, and Bégin, Jean

Abstract

A near infrared (NIR) spectrometer, equipped with a 2-mm diameter fiber optic probe, was used to develop a rapid and automated method for determining the radial profiles of wood properties for six tree species of the boreal forest of eastern Canada. Partial least squares regressions were performed using individual spectra, collected every 5 mm, from the pith to the bark, using 1,538 samples previously scanned by SilviScan to provide reference data. Results obtained for density (r^2 of 0.57 to 0.65; SE of 21 to 33 kg/m^3), microfibril angle (0.56 to 0.82, 2.3 to 4.8°) and modulus of elasticity (0.71 to 0.85, 1.3 to 1.8 GPa) were suitable for the purpose of this study. This method was then applied to more than 30,000 tree cores and the resulting radial profiles of the properties were consistent with literature. Area-weighted average predictions also gave reliable estimates at the disk scale. NIR-estimated values were strongly correlated to the measured density (r of 0.83 to 0.93) and modulus of elasticity (0.82 to 0.88) and moderately correlated to measured microfibril angle (0.64 to 0.78). Radial profiles of wood properties are needed to characterize the proportions of juvenile and mature wood. The developed method therefore offers interesting opportunities for estimating the quality of wood fiber in trees growing in plantation or natural forest.

Published
2021

50. EEG Resting-State and Event-Related Potentials as Markers of Learning Success in Older Adults Following Second Language Training: A Pilot Study

Author

Kliesch, Maria, Giroud, Nathalie, and Meyer, Martin

Abstract

In this pilot study, we evaluated the use of electrophysiological measures at rest as paradigm-independent predictors of second language (L2) development for the first time in older adult learners. We then assessed EEG correlates of the learning outcome in a language-switching paradigm after the training, which to date has only been done in younger adults and at intermediate to advanced L2 proficiency. Ten (Swiss) German-speaking adults between 65–74 years of age participated in an intensive 3-week English training for beginners. A resting-state EEG was recorded before the training to predict the ensuing L2 development (Experiment 1). A language-switching ERP experiment was conducted after the training to assess the learning outcome (Experiment 2). All participants improved their L2 skills but differed noticeably in their individual development. Experiment 1 showed that beta1 oscillations at rest (13–14.5 Hz) predicted these individual differences. We interpret resting-state beta1 oscillations as correlates of attentional capacities and semantic working memory that facilitate the extraction and processing of novel forms and meanings from the L2 input. In Experiment 2, we found that language switching from the L2 into the native language (L1) elicited an N400 component, which was reduced in the more advanced learners. Thus, for learners beginning the acquisition of an L2 in third age, language switching appears to become less effortful with increasing proficiency, suggesting that the lexicons of the L1 and L2 become more closely linked. In sum, our findings extend the available evidence of neurological processes in L2 learning from younger to older adults, suggesting that electrophysiological mechanisms are similar across the lifespan.

Published
2021
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