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Background: Electroacupuncture (EA) has been demonstrated to be efficacious and safe in patients with knee osteoarthritis (KOA), yet the optimal current intensity for pain control in KOA remains unspecified. The present meta-analysis aimed to compare the effects of high-intensity and low-intensity EA in terms of pain relief and functional improvement in KOA.Methods: A thorough and comprehensive literature search for randomized controlled trials (RCTs), all looking at the intensity of EA for KOA, was carried out in PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science Journal Citation Report (VIP) and Wanfang database, as well as ClinicalTrials.gov. All databases were searched from their inception until April 2022. Study quality was assessed using the Cochrane risk of bias (RoB)2 tool. Finally, a meta-analysis of all eligible RCTs was performed using Review Manager 5.3.Results: Three studies with 472 individuals were included in the meta-analysis. The pain intensity reductions were significantly different between the high-intensity EA group and low-intensity EA group (mean difference (MD) = −0.22, 95% confidence interval (CI) = −0.26 to −0.18, p< 0.00001). There was no significant difference between the two groups in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores (MD = −3.62, 95% CI = −12.22 to 4.98, p= 0.41). High-intensity EA significantly improved emotional scale (ES) scores compared to low-intensity EA (MD = −0.72, 95% CI = −0.76 to −0.67, p< 0.00001).Conclusion: The findings of this systematic review and meta-analysis indicated that high-intensity EA provides superior pain relief and has a bigger impact on emotional scale scores in patients with KOA.

The aim is to establish a model of nonalcoholic fatty liver disease (NAFLD) caused by feeding with high-fat, high-fructose, and high-cholesterol diet (HFFCD) in golden hamsters, and to investigate the characteristics of the NAFLD model and metabolite changes of liver tissue. Golden hamsters were fed HFFCD or control diets for six weeks. Body weight, abdominal fat index, and liver index was assessed, serum parameters, hepatic histology, and liver metabolites were examined. The results showed that body weight, abdominal fat, and liver index of hamsters were significantly increased in the model group, the level of serum total cholesterol (TC), triglyceride (TG), and low density lipoprotein-cholesterol (LDL-C) were significantly increased in model group as well, and high density lipoprotein-cholesterol (HDL-C) was significantly decreased. In addition, lipid deposition in liver tissue formed fat vacuoles of different sizes. Metabonomics analysis of the liver showed that the metabolic pathways of sphingolipid, glycerophospholipids, and arginine biosynthesis were disordered in the NAFLD model. The modeling method is simple, short time, and uniform. It can simulate the early fatty liver caused by common dietary factors, and provides an ideal model for the study of the initial pathogenesis and therapeutic drugs for NAFLD.

Increased expressions of miR-21 have been detected in ankylosing spondylitis (AS) patients. The current study was performed to examine the serum miR-21 expression with radiographic severity in AS patients, which was determined based on the modified New York (NY) criteria for sacroiliac joints assessment and modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) system for spine involvement. Bone mineral density at lumbar 1–4 and femoral neck were examined by dual-energy absorptiometry (DXA). Serum miR-21 expressions were determined by quantitative real-time PCR, and receiver operating characteristic curve analysis was performed to identify the diagnostic value of miR-21 expression levels regarding the NY criteria. Elevated levels of serum miR-21 expressions were detected in AS patients compared with healthy controls. AS patients with modified NY grade 4 showed significantly higher miR-21 expression than grade 3 and grade 2. AS patients with spinal syndesmophytes had significantly higher serum miR-21 expressions than non-syndesmophyte patients. Increased miR-21 expressions were significantly related to the disease radiographic severity. In addition, serum miR-21 expressions were negatively associated with lumbar 1–4 and femoral neck bone mineral density. In summary, serum miR-21 expressions were related to structural damage and radiological progression in AS, indicating that miR-21 may act as a switch between inflammation and new bone information and regulate different signal ways between lesioned enthesis and trabecular bone.

Objective Our study was performed to investigate whether micro-223 promotes diabetic Osteoarthritis (OA) progression by regulating cartilage degeneration and subchondral bone remodeling.Methods The expression of miR-223 in human normal cartilage, OA cartilage, and subchondral bone tissue with or without DM was detected by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). miR-223 mimic or inhibitor was transfected into chondrocytes. Cell viability and apoptosis were assessed by 3-(4,5)-dimethylthiahiazo(-2)-3,5-diphenyltetrazolium bromide (MTT) and Terminal Deoxynucleotidyl Transferase(TdT)-mediated dUTP nick end labeling (TUNEL) assay, respectively.Results miR-223 was significantly higher in human diabetic OA cartilage and subchondral bone compared with normal OA and healthy control. Overexpression of miR-223 accelerated cartilage degeneration and subchondral bone sclerosis in diabetic OA mice, whereas miR-223 inhibition had the opposite effect. In vitroupregulation of miR-223 decreased proliferation and enhanced apoptosis of chondrocytes. Meanwhile, downregulation of miR-223 promoted glycosaminoglycan (GAG) production in chondrocytes.Conclusion miR-223 promotes diabetic OA progression by regulating cartilage degeneration and subchondral bone remodeling both in vitroand in vivo.

The common point coordinate precision affect accuracy of coordinate transformation. In order to overcome the individual common point coordinate precision is too low or the error is large under some condition, a new method of high-precision coordinate transformation based on bursa model was discussed, which used the theory of robust resistance estimation to solve and calculate the high-precision coordinate transformation parameters, finally achieved the purpose of high-precision coordinate transformation. By calculation and comparison with experimental date, the result show that the method is practical and effective, so it is completely feasible in application surveying engineering.

Bi2O3 Chaplet-like Nanoparticles have been fabricated. Most of them have the average inner diameter of 200nm and the mean rim thickness of 20nm. Photoluminescence spectra of the nanorings at room temperature were investigated, which demonstrated that the rings present excellent optical properties. The influence of aging time on the morphology and structure of β-Bi2O3 superstructures was also studied, indicating that the nanorings superstructures were transformed into nanoplates after a long aging time. The formation mechanism of the β-Bi2O3 superstructures was also explored. This approach will be further extended to solvent-controlled fabrication of related minerals with novel complex superstructures.

Bi2O3 Chaplet-like Nanoparticles have been fabricated. Most of them have the average inner diameter of 200nm and the mean rim thickness of 20nm. Photoluminescence spectra of the nanorings at room temperature were investigated, which demonstrated that the rings present excellent optical properties. The influence of aging time on the morphology and structure of β-Bi2O3 superstructures was also studied, indicating that the nanorings superstructures were transformed into nanoplates after a long aging time. The formation mechanism of the β-Bi2O3 superstructures was also explored. This approach will be further extended to solvent-controlled fabrication of related minerals with novel complex superstructures.

The consensus problems of two situations for singular multi-agent systems with fixed topology are discussed: directed graph without spanning tree and the disconnected undirected graph. A sufficient and necessary condition is obtained by applying the stability theory and the system is reachable asymptotically. But for normal systems, this can’t occur in upper two situations. Finally a simulation example is provided to verify the effectiveness of our theoretical result.

Consensus of singular multi-agent systems is studied, where the dynamics of each agent is described by a continuous-time singular system. Based on the controllability theory of singular systems, the consensus problem under consideration is transformed into the stability problem of a low-order normal system. Moreover, a sufficient and necessary condition for consensus is obtained by applying the stability theory. Finally, simulation examples are provided to validate the theoretical results.

Noise identification is one of the most important issues in radar and sonar engineering, in which Kolmogorov–Smirnov (KS) statistic is widely adopted. Although KS statistic is the most reliable method till now, it does not have high precision as people believe. The performance of KS statistic is studied in this work, while an experiment is carried out to show the precision of KS statistic, including both test and recognition. The result could help researchers decreasing error of using KS statistic in the future.