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Herein, we detail the synthesis, structure, and photoconductivity of the uranyl dithiophosphinate single crystal UO2[S2P(C6H5)2]2(CH3OH)·CH3OH (denoted as U-DPDPP). The formation of bonds between uranyl ions and sulfur-based ligands endows U-DPDPP with a distinct electronic absorption property with a broadband spectrum spanning from 250 to 550 nm, giving rise to a unique semiconductive property. Under X-ray illumination, U-DPDPP displays a distinctive photoconductivity response, with a charge carrier mobility lifetime (μτ) of 2.78 × 10–4cm2·V–1achieved, which contradicts the electronic-silence behavior of uranyl nitrate crystal.

All-day satellite observations are crucial for communications, navigation, and remote sensing. Current systems rely on large, long-focal-length telescopes that struggle with daytime surveillance. Compact, short-focal-length star trackers, which are designed for measuring stellar positions and determining satellite attitudes, offer flexibility and rapid tracking but typically cannot operate during the day. In this article, we present a novel optical beacon and a star tracker for all-day ground-based satellite observations. The parameters of the star tracker and the onboard beacon system are optimized by analyzing the signal-to-noise ratio (SNR) between the atmospheric background radiation and the flux from the illumination source. In experiments with a 70-W peak illumination power and a 15° divergence angle, all-day satellite observations were achieved for a satellite at 500 km using a 15° ground-based observation angle. At night, the brightest observed satellite magnitude reached 1.19 at a distance of 570 km, while during the daytime, the SNR reached 20.17 dB at a distance of 538 km. This study significantly enhances the all-day satellite observation capability, fills the gap in daytime monitoring of satellites using star trackers, and provides strong support for future satellite space applications.

Metallofullerenes are an important type of metallic nanomaterial with promising applications in several medical fields. Thermal ablation, including radiofrequency ablation (RFA) and microwave ablation (MWA), is an important treatment strategy for advanced hepatocellular carcinoma (HCC). The thermal expansion of fullerenes makes them good adjuncts to thermal ablation treatment of HCC. In this study, we used an innovative method of emulsification and cross-linking to produce CS-C60-Fe3O4(Chitosan-C60-Fe3O4) nanoparticles, which have the advantages of uniform particle size and high bioavailability, as a kind of novel nano-pharmaceutical. The CS-C60-Fe3O4nanoparticles were prepared by the cross-linking reaction from chitosan–acetic acid solution, Fe3O4nanoparticles by Fe2SO4·7H2O and FeCl3·6H2O, and C60. The average particle size of CS-C60-Fe3O4was 194.3 nm. Because CS-C60-Fe3O4is magnetic, it can achieve specific and tissue aggregation in HCC tumor tissues. Moreover, compared with normal soluble C60(EL35-C60), CS-C60-Fe3O4prolonged the retention time of C60in the blood of mice. CS-C60-Fe3O4alone is not cytotoxic to cultured cells or tumor tissues, but when combined with thermal ablation strategies (RFA and MWA), it significantly upregulates the antitumor effects of thermal ablation on HCC tissues, that is, it acts as a sensitiser to thermal ablation. In the presence of thermal ablation, CS-C60-Fe3O4interfered with iron metabolism in HCC cells and induced ferroptosis of HCC cells in the tumor tissues. These results not only expand our understanding of metallofullerenes but also provide additional options for the treatment of advanced HCC.

As the complexity of flight missions continues to increase, sending a timely warning or providing assistance to pilots helps to reduce the probability of operational errors and flight accidents. Monitoring pilots’ physiological data, real-time evaluation of mission load is a feasible technical way to achieve this. In this paper, a set of flight tasks including aircraft control, human-computer interaction and mental arithmetic tests are designed to simulate five mission loads at different flight difficulty levels. A sensitivity analysis method based on a comprehensive test is proposed to select a set of sensitive physiological factors. Then, based on the SVM hierarchical combination classification method, the pilot mission load real-time evaluation model is established. The test results show significant differences in EMG, respiration rate (abdomen), heart rate, blood oxygen saturation, pupil area, fixation duration, number of fixations, and saccades. The high accuracy obtained from experiments proved that the proposed real-time evaluation model is applicable to meet the requirements of real working environments. The findings can provide methodological references for mission load evaluation research in other fields.

The in-orbit network observation and data recording and playback of Fengyun-3 is limited by the configuration of domestic ground stations and the Antarctic station, which may potentially affect the integrity and timeliness of global data reception. This paper expounds the autonomous program control design of global data recording and playback of FY-3E satellite and the efficient data processing and transmission process, establishes a data timeliness simulation analysis model and analyzed the timeliness of payload data acquisition under different strategies of data playback toward Antarctic station. The analysis results and experimental verification show that the integrity and timeliness of global data acquisition can be ensured by optimizing the use frequency of the Antarctic station.

In wireless power transfer systems, the enhancement of dynamic response may result in inferior steady-state response. To deal with the contradictions, the weighting function in the robust control design systems should be chosen carefully. So the selection of designed parameters would become a complicated and practically time-consuming problem. In this paper, a multi-objective optimisation scheme for operator-based robust nonlinear control of wireless power transfer systems is proposed by using modified ant colony optimisation algorithm to determine the values of designed parameters. First, the evaluation function to estimate system performance is formulated to guarantee its robustness and tracking performance. Then modified ant colony optimisation (MACO) algorithm is applied to search optimal values for designed parameters. Finally, the simulations results are presented to show good dynamic and steady response of the WPT systems even when the uncertain term exists.

Background: Stem cells are undifferentiated cells with multilineage differentiation potential. They can be collected from bone marrow, fat, amniotic fluid, and teeth. Stem cell-based therapies have been widely used to treat multiple diseases, such as cardiac disease, and hematological disorders. The cells may also be beneficial for controlling the disease course and promoting tissue regeneration in oral and maxillofacial diseases. Oral-derived gingival mesenchymal stem cells are easy to access and the donor sites heal rapidly without a scar. Such characteristics demonstrate the beneficial role of GMSCs in oral and maxillofacial diseases. Objective: We summarize the features of GMSCs, including their self-renewal, multipotent differentiation, immunomodulation, and anti-inflammation properties. We also discuss their applications in oral and maxillofacial disease treatment and tissue regeneration. Conclusion: GMSCs are easily harvestable adult stem cells with outstanding proliferation, differentiation, and immunomodulation characteristics. A growing body of evidence indicates that GMSCs have strong potential use in accelerating wound healing and promoting the regeneration of bone defects, periodontium, oral neoplasms, salivary glands, peri-implantitis, and nerves. Moreover, alginate, polylactic acid and polycaprolactone can be used as biodegradable scaffolds for GMSC encapsulation. Various growth factors can be applied to the corresponding scaffolds to obtain the desired GMSC differentiation and phenotypes. Three-dimensional spheroid culture systems could optimize GMSC properties and improve the performance of the cells in tissue engineering. The immunomodulatory property of GMSCs in controlling oral and maxillofacial inflammation needs further research.

Targeting dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) has been verified to regulate the progression of tau pathology as a promising treatment for Alzheimer’s disease (AD), while the research progress on DYRK1A inhibitors seemed to be in a bottleneck period. In this work, we identified 32(ZJCK-6-46) as the most potential DYRK1A inhibitor (IC50= 0.68 nM) through rational design, systematic structural optimization, and comprehensive evaluation. Compound 32exhibited acceptable in vitroabsorption, distribution, metabolism, and excretion (ADME) properties and significantly reduced the expression of p-Tau Thr212 in Tau (P301L) 293T cells and SH-SY5Y cells. Moreover, compound 32showed favorable bioavailability, blood–brain barrier (BBB) permeability, and the potential of ameliorating cognitive dysfunction by obviously reducing the expression of phosphorylated tau and neuronal loss in vivo, which was deserved as a valuable molecular tool to reveal the role of DYRK1A in the pathogenesis of AD and to further promote the development of anti-AD drugs.

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The reduction process of pre-oxidized ilmenite concentrate powder in 30%CO–70%N2atmosphere was characterized by thermogravimetric and differential thermogravimetric (TG-DTG) analysis system at the temperature from 1073 to1223 K. The isothermal reduction results show that the reduction process is divided into three stages and the corresponding apparent activation energies are obtained by iso-conversional method and model-fitting method, respectively. For the first stage, the conversion degree increases sharply with increasing time, and the reduction process is controlled by the random nucleation and subsequent growth model (A2model). For the second stage, the conversion degree increases slowly with increasing time, and the reduction process is controlled by the diffusion of carbon monoxide in the reduced layer (D1model). For the third stage, the reduction processes at different temperatures are controlled by the diffusion of carbon monoxide in the reduced layer (1073 K and D1model), phase boundary chemical reaction (1123 K and R2model), random nucleation and subsequent growth (1173 to 1223 K, A2, and A3models), respectively. For the whole reduction process, the apparent activation energies obtained by iso-conversional method and model-fitting method are 71.72 and 31.92 kJ mol−1, respectively.

As a functional food, the unripe fruits of Rubus chingiiHu have been widely used in China for thousands of years. Twenty-five major ellagitannins (ETs) were identified from the unripe fruits, and a novel ellagitannin, chingiitannin A (1), together with four other known ETs (2–5) were isolated and identified by HPLC-QTOF-MS/MS and 2D-NMR. Chingiitannin A showed the highest α-glucosidase and α-amylase inhibitory activities (IC502.89 and 4.52 μM, respectively), which occurred in a reversible and noncompetitive manner. Static quenching was indicated in a fluorescence quenching assay. Molecular docking results revealed that chingiitannin A interacted with the enzymes mainly by hydrogen bonding and was bound in the allosteric site. Chingiitannin A was nontoxic, and it increased the glucose uptake in L6 myotubes. The results suggested that the unripe fruits of Rubus chingiiHu are rich sources of ETs, and chingiitannin A might be a good candidate for functional foods or antidiabetic drugs.

ABSTRACTThe reduction of chromium-bearing vanadium–titanium magnetite sinter (CVTMS) by CO was investigated at 1123–1223 K. The reduction degree increased with increasing temperature. The isothermal reduction kinetics of CVTMS was analysed, according to Sharp analysis and ln–ln analysis, the kinetic mechanism of reduction process for all samples in different basicity can be represented as f(α) = 1.61(1−α)[−ln(1−α)]1–1/1.61. The reaction activation energy of all samples (R = 1.9, 2.1, 2.3, obtained according to the components of the materials burdening used in sintering process) at different reaction degrees were calculated by the model-free method. And the pre-exponential factors of reaction also were calculated by the mathematical method. The rate controlling step for the reduction process under the present reduction condition was chemical reaction.

In this paper, we introduce and study differential graded (DG for short) polynomial algebras. In brief, a DG polynomial algebra Ais a connected cochain DG algebra such that its underlying graded algebra A#is a polynomial algebra $$\mathbb{K}[x_1, x_2, \ldots, x_{n}]$$K[x1,x2,…,xn]with |xi| = 1, for any i∈ {1, 2, ..., n}. We describe all possible differential structures on DG polynomial algebras; compute their DG automorphism groups; study their isomorphism problems; and show that they are all homologically smooth and Gorenstein DG algebras. Furthermore, it is proved that the DG polynomial algebra Ais a Calabi-Yau DG algebra when its differential ∂A≠ 0 and the trivial DG polynomial algebra (A, 0) is Calabi-Yau if and only if nis an odd integer.

OVERVIEW:Firms in emerging markets have traditionally followed one of two strategies to catch up with multinational enterprises (MNEs): developing customized products, services, or innovative business models or buying and absorbing technology from MNEs. In the era of globalization, these strategies are no longer effective. The new strategy to succeed is innovation-based differentiation, developing core technologies and advanced product offerings that are delivered at a low cost and with excellent customer service. Using this strategy, leading local firms are quickly catching up with MNEs in market development, technology development, or both.

AbstractBackgroundAt 9:28 pmon June 1, 2015, the cruise ship “Oriental Star” sank into Yangtze River in Jianli County, with 422 people killed. When the accident occurred, the Chinese government took immediate action and dispatched more than 9000 rescuers. The risk for outbreak of schistosomiasis was increased because of the shipwreck. Obviously it is critical to carry out risk assessment as soon as possible.MethodsBy means of the Delphi method, the situation was analyzed so that the government could fathom the severity of the accident. Then, through matrix and sigma-plotting (3-dimensional graphics) methods, related authorities performed risk assessment after site investigation.ResultsThe latest news reported that more than 9000 people were involved in the rescue. The affected river was analyzed and mapped using SigmaPlot software, according to which the possibility, harmfulness, and controllability of the accident were determined to be medium (6), medium (6), and poor (7), respectively.ConclusionThe site of the accident where the cruise ship sank and rescue operations were carried out is a schistosomiasis epidemic area with high mortality and morbidity. The chance of an outbreak of the schistosomiasis epidemic in Jianli County is quite high. To protect people in this county from the epidemic, relevant logistic services should be arranged and all remains should be cleared up carefully. (Disaster Med Public Health Preparedness. 2018;12:147–153)

AbstractObjective:The purpose of this study was to explore the level of coronavirus disease 2019 (COVID-19) vaccine hesitancy among medical students in Wuhan, China, and to identify the factors and barriers associated with their vaccination decision.Methods:A cross-sectional survey was launched with 612 medical students recruited by convenience sampling from 6 universities. Data collection measures mainly included a demographic questionnaire, COVID-19 vaccine knowledge questionnaire, and the vaccine hesitancy scale.Results:A total of 58.2% of medical students reported vaccine hesitancy. The most common reasons for this were worrying about the side effects of vaccines (44.4%), uncertainty about vaccine safety (40.4%), and underestimating the risk of exposure to COVID-19 (27.9%). The main factors associated with COVID-19 vaccine hesitancy among participants were their knowledge about COVID-19 vaccine, training related to COVID-19 vaccines, family address, and education level (P< 0.05).Conclusions:The government, health department and universities in China need to work together and actively communicate with vaccine-hesitant students, establish a standardized COVID-19 vaccine course, and provide on-campus vaccination services.

Background: The dynamic viscosity-temperature characteristics of lubricants are the main factors used to determine the oil film thickness and carrying capacity. There are few studies on the factors affecting the dynamic viscosity-temperature characteristics of lubricating oils and the dynamic viscosity-temperature model. Objective: This research aims to analyse the influences of lubricating oil type and initial kinematic viscosity on dynamic viscosity-temperature characteristics and present a new dynamic viscositytemperature model. Methods: The characteristic curves of dynamic viscosity versus temperature of polyol ester oil, paraffinic mineral oil, and five types of PAO (poly α-olefin) oils with different initial viscosities were obtained by using a kinematic viscosity test device and a density test device. The influences of lubricating oil type and lubricating oil viscosity on dynamic viscosity-temperature characteristics were analysed. A new dynamic viscosity-temperature model was presented based on our patent technology and repeated verification. Results: Viscosity-temperature curves of three different types of lubricating oils and viscositytemperature curves of PAO oils with different initial kinematic viscosities were obtained. A new dynamic viscosity-temperature model η = A x e(-T/n) + η0 was proposed. Conclusion: The dynamic viscosity-temperature characteristics of lubricating oils are not only determined by the type of oils but also determined by the initial kinematic viscosity. The variation of dynamic viscosity of lubricating oils with temperature in the scope of -40~110°C can be described by the following viscosity-temperature model: η = A x exp (-T/n) + η0 which can be used in a wider temperature range than the existing models.

MicroRNA-153 (miR-153) is considered to be a tumor regulator. Silencing of miR-153 expression induced apoptosis in breast cancer cells. Data on mechanism suggest that up-regulation of miR- 153 level promotes cell proliferation via the down regulation of the expression of PTEN or FOXO1, which attenuates the proliferation of cancerous cells. This study aims to identify the effect of miR-153 on the activity of chemotherapeutic and targeted agents in HCC cells and to investigate the mechanisms involved. MTT, soft agar, trans-well and flow cytometry assays were performed to examine whether miR-153 down-regulated the activity of the chemotherapeutic and targeted drugs, Sorafenib, Etoposide and Paclitaxel in HCC cells. The rate of proliferation inhibition, relative survival rates and IC50 values of each drug were calculated. Western blot and luciferase assays were performed to assess whether miR-153 modulates the expression of important genes related to cell proliferation, apoptosis or survival. Results showed that miR-153 attenuated the effect of Etoposide, Paclitaxel and Sorafenib on HepG2 cells; the IC50 value increased from 0.25±0.01μmol/L to 1.02±0.14μmol/L, 0.05±0.01μmol/L to 0.14±0.02μmol/L and from 1.09±0.15μmol/L to 5.18±0.99μmol/L, respectively. In addition, miR-153 also reduced the effect of these drugs on MHCC- 97H, MHCC-97 L and L-02 cells; and it also reduced the effects of Sorafenib, Etoposide and Paclitaxel on anchorindependent growth of HepG2 cells. Over-expression of miR-153 down-regulated the activity of Etoposide and Paclitaxel on cell cycle arrest of HepG2 cells and the effect of Sorafenib on the invasion and migration of HepG2 cells. Furthermore, overexpression of miR-153 also enhanced the growth of HepG2, MHCC-97H, MHCC-97 L and L-02 cells. Mechanisms data showed that overexpression of miR-153 down regulated the activity of luciferase reporters, p15-Luc and p21-Luc; and enhanced the protein level of pro-survival or anti-apoptosis proteins Survivin and BCL-2. These results show that overexpression of miR-153 protects HepG2 cells against the effects of these drugs via multiple mechanisms, and miR-153 may be a novel target for HCC in future diagnostic and therapeutic interventions.

The distribution of science and technology resources in China has encountered a series of problems including, for example, scattered resources, unnecessary duplication and ineffective management. To facilitate access to these valuable resources, the Beijing Science and Technology Committee, a local government agency, established the Beijing Science and Technology Resource Platform (BSTRP) in 2009. BSTRP introduced market-oriented professional service companies as third parties acting in cooperation with suppliers and end users of science and technology resources. The aim of BSTRP was to create a win–win mechanism without dramatically changing the existing institutional framework or disturbing the basic interests of the participants. In this paper the authors report on the development of BSTRP and its progress to date. They also discuss the theoretical implications of the BSTRP model.

The distribution of science and technology resources in China has encountered a series of problems including, for example, scattered resources, unnecessary duplication and ineffective management. To facilitate access to these valuable resources, the Beijing Science and Technology Committee, a local government agency, established the Beijing Science and Technology Resource Platform (BSTRP) in 2009. BSTRP introduced market-oriented professional service companies as third parties acting in cooperation with suppliers and end users of science and technology resources. The aim of BSTRP was to create a win–win mechanism without dramatically changing the existing institutional framework or disturbing the basic interests of the participants. In this paper the authors report on the development of BSTRP and its progress to date. They also discuss the theoretical implications of the BSTRP model.

Transforming new start-ups into well established firms is a complex process and contains the management of many complex and challenging tasks. In this paper, we examine the roles played by some Chinese cultural values in facilitating the development of effective strategies to manage these tasks and argue that these cultural values are of critical importance because they could be the cognitive basis for developing a paradoxical frame that helps managers to recognise and accept the simultaneous existence of contradictions, develop a more effective cognitive representation when facing a rugged landscape and identify effective management rules in complex environment.

Objective To investigate SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 (SPOCK1) gene expression across The Cancer Genome Atlas (TCGA) cancers, both in cancer versus normal tissues and in different stages across the cancer types.Methods This integrated bioinformatics study used data from several bioinformatics databases (Cancer Cell Line Encyclopedia, Genotype-Tissue Expression, TCGA, Tumor Immune Estimation Resource [TIMER]) to define the expression pattern of the SPOCK1gene. A survival analysis was undertaken across the cancers. The search tool for retrieval of interacting genes (STRING) database was used to identify proteins that interacted with SPOCK1. Gene Set Enrichment Analysis was conducted to determine pathway enrichment. The TIMER database was used to explore the correlation between SPOCK1and immune cell infiltration.Results This multiomic analysis showed that the SPOCK1gene was expressed differently between normal tissues and tumours in several cancers and that it was involved in cancer progression. The overexpression of the SPOCK1gene was associated with poor clinical outcomes. Analysis of gene expression and tumour-infiltrating immune cells showed that SPOCK1correlated with several immune cells across cancers.Conclusions This research showed that SPOCK1might serve as a new target for several cancer therapies in the future.

Dietary fiber from Lentinula edodes(LEDF) residues were obtained using various extrusion conditions and their physicochemical and functional properties, such as glucose adsorption capacity (GAC), water holding capacity, oil holding capacity, glucose retardation (GRI) and bile acid retardation index (BRI) were measured. Based on principal component analysis, the optimal extrusion conditions were determined, i.e., extrusion temperature 130 °C, moisture content 40% and screw speed 125 r/min. The dietary fiber contained 3.6% soluble and 88% insoluble dietary fiber and the major components were cellulose (26%) and hemicellulose (42%). Compared with untreated fibers, GAC and BRI of LEDF with optimal extrusion conditions increased 0.46 mg/mg and 28%, respectively. Regression analysis suggested that GRI and hemicellulose showed a significant positive correlation (p≤0.05). Overall, it could be suggested that the LEDF obtained with the optimized extrusion condition might be used as a potential ingredient in functional foods.

ABSTRACTDespite the success of CD20 antibody rituximab in immunotherapy, acquired resistance is one of the prime obstacles for the successful treatment of B-cell malignancies. There is an urgent need to intensify efforts against resistance in cancer treatment. Growing evidence indicated that lysosomes may form an “Achilles heel” for cancer cells by sensitizing them to death pathways. Here, we uncover an important role of CD20 in initiation of ceramide/lysosomal membrane permeabilization (LMP)-mediated cell death, showing that colocalization of CD20-TNFR1 after type II CD20 antibody ligation can stimulate de novoceramide synthesis by ceramide synthase and consequently induce remarkable lysosomal permeabilization (LMP) and lysosome-mediated cell death. Further studies show that the potent lysosome-mediated cell death induced by CD20 antibodies exhibits a profound killing effect against both rituximab-sensitive and -resistant (RR) lymphoma. Furthermore, engineering of rituximab by introducing a point mutation endows it with the ability to induce potent ceramide/LMP-mediated cell death in both RR lymphoma and primary B-cell malignancies from patients with rituximab-refractory, suggesting the potential clinical application to combat rituximab resistance.

Although trastuzumab has succeeded in breast cancer treatment, acquired resistance is one of the prime obstacles for breast cancer therapies. There is an urgent need to develop novel HER2 antibodies against trastuzumab resistance. Here, we first rational designed avidity-imporved trastuzumab and pertuzumab variants, and explored the correlation between the binding avidity improvement and their antitumor activities. After characterization of a pertuzumab variant L56TY with potent antitumor activities, a bispecific immunoglobulin G-like CrossMab (Tras-Permut CrossMab) was generated from trastuzumab and binding avidity-improved pertuzumab variant L56TY. Although, the antitumor efficacy of trastuzumab was not enhanced by improving its binding avidity, binding avidity improvement could significantly increase the anti-proliferative and antibody-dependent cellular cytotoxicity (ADCC) activities of pertuzumab. Further studies showed that Tras-Permut CrossMab exhibited exceptional high efficiency to inhibit the progression of trastuzumab-resistant breast cancer. Notably, we found that calreticulin (CRT) exposure induced by Tras-Permut CrossMab was essential for induction of tumor-specific T cell immunity against tumor recurrence. These data indicated that simultaneous blockade of HER2 protein by Tras-Permut CrossMab could trigger CRT exposure and subsequently induce potent tumor-specific T cell immunity, suggesting it could be a promising therapeutic strategy against trastuzumab resistance.