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22 results on '"Galicier, L."'

1. Prognosis of Lymphoma in Patients With Known Inflammatory Bowel Disease: A French Multicentre Cohort Study.

Author

Severyns, T, Kirchgesner, J, Lambert, J, Thieblemont, C, Amiot, A, Abitbol, V, Treton, X, Cazals-Hatem, D, Malamut, G, Coppo, P, Galicier, L, Walter-Petrich, A, Deau-Fischer, B, Besson, C, Aparicio, T, Beaugerie, L, Allez, M, and Gornet, J M

Abstract

Background and Aims The prognosis of lymphoma that occurs in patients with inflammatory bowel disease [IBD] is poorly known. Methods A multicentre retrospective cohort analysis was done in seven French tertiary centres from 1999 to 2019. Only lymphoma occurring in patients with previous established diagnosis of IBD were analysed. The primary outcome was progression-free survival at 3 years. Results A total of 52 patients [male 65%, Crohn's disease 79%, median age 48.3 years, median duration of IBD 10.1 years] were included, of whom 37 had been previously exposed to immunosuppressants and/or biologics for at least 3 months and 20 had primary intestinal lymphomas. The lymphoma histological types were: diffuse large B cell lymphomas [ N  = 17], Hodgkin lymphomas [ N  = 17], indolent B cell lymphomas [ N  = 12], and others including T cell lymphomas, mantle cell lymphomas, and unclassifiable B cell lymphoma [ N  = 6]. The median follow-up after lymphoma was 5.1 years (interquartile range [IQR] 4–7.8). Progression-free survival at 3 years was 85% in the overall population (95% confidence interval [CI] 75%–96%) with no significant difference between the exposed and unexposed group, 79% for patients exposed to immunosuppressants and/or biologics [95% CI 67%–94%], and 83% for patients diagnosed with primary intestinal lymphoma [95% CI 67%–100%]. No relapse of IBD has been observed during chemotherapy. The IBD relapse rate at the end of the last chemotherapy cycle was 23% at 3 years [95% CI 11%-39%] in the overall population. Conclusions In this large cohort, the prognosis for lymphomas occurring in IBD appears to be good and similar to what is expected, irrespective of the exposure to biologics and/or immunosuppressants. [ABSTRACT FROM AUTHOR]

Published
2020
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2. Exclusion of Patients with a Severe T-Cell Defect Improves the Definition of Common Variable Immunodeficiency

Author

Bertinchamp, Rémi, Gérard, Laurence, Boutboul, David, Malphettes, Marion, Fieschi, Claire, Oksenhendler, Eric, Oksenhendler, E., Fieschi, C., Malphettes, M., Galicier, L., Boutboul, D., Fermand, J.P., Viallard, J.F., Jaccard, A., Hoarau, C., Lebranchu, Y., Bérezné, A., Mouthon, L., Karmochkine, M., Schleinitz, N., Durieu, I., Nove-Josserand, R., Chanet, V., Le-Moing, V., Just, N., Salanoubat, C., Jaussaud, R., Suarez, F., Hermine, O., Solal-Celigny, P., Hachulla, E., Sanhes, L., Gardembas, M., Pellier, I., Tisserant, P., Pavic, M., Bonnotte, B., Haroche, J., Amoura, Z., Alric, L., Thiercelin, M.F., Tetu, L., Adoue, D., Bordigoni, P., Perpoint, T., Sève, P., Rohrlich, P., Pasquali, J.L., Korganow, A.S., Soulas, P., Couderc, L.J., Catherinot, E., Giraud, P., Baruchel, A., Deleveau, I., Chaix, F., Donadieu, J., Tron, F., Larroche, C., Blanc, A.P., Masseau, A., Hamidou, M., Kanny, G., Morisset, M., Millot, F., Fain, O., Borie, R., Perlat, A., Bienvenue, B., Autran, B., Gorochov, G., Garnier, J.L., Moins, H., Maki, G., Fieschi, C., Malphettes, M., Boutboul, D., and Gérard, L.

Abstract

In 2014, the European Society for Immune Deficiencies (ESID) revised the common variable immunodeficiency (CVID) diagnosis criteria by incorporating new clinical and biological markers. The new definition appeared more restrictive but had not yet been evaluated in a large cohort of patients.

Published
2016
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3. Acute renal failure is prevalent in patients with thrombotic thrombocytopenic purpura associated with low plasma ADAMTS13 activity

Author

Zafrani, L., Mariotte, E., Darmon, M., Canet, E., Merceron, S., Boutboul, D., Veyradier, A., Galicier, L., and Azoulay, E.

Abstract

Among patients with thrombotic microangiopathies, acute kidney injury (AKI) is the hallmark of hemolytic uremic syndrome (HUS) and is largely underestimated in patients with thrombotic thrombocytopenic purpura (TTP).

Published
2015
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4. Cardiac troponin‐I on diagnosis predicts early death and refractoriness in acquired thrombotic thrombocytopenic purpura. Experience of the French Thrombotic Microangiopathies Reference Center

Author

Benhamou, Y., Boelle, P.‐Y., Baudin, B., Ederhy, S., Gras, J., Galicier, L., Azoulay, E., Provôt, F., Maury, E., Pène, F., Mira, J.‐P., Wynckel, A., Presne, C., Poullin, P., Halimi, J.‐M., Delmas, Y., Kanouni, T., Seguin, A., Mousson, C., Servais, A., Bordessoule, D., Perez, P., Hamidou, M., Cohen, A., Veyradier, A., Coppo, P., Elie, Azoulay, Virginie, Barbay, Guy, Bonmarchand, Dominique, Bordessoule, Christophe, Charasse, Dominique, Chauveau, Gabriel, Choukroun, Jean‐Philippe, Coindre, Paul, Coppo, Elise, Corre, Yahsou, Delmas, Georges, Deschenes, Alain, Devidas, Olivier, Fain, Véronique, Frémeaux‐Bacchi, Lionel, Galicier, Bertrand, Guidet, Jean‐Michel, Halimi, Mohamed, Hamidou, Raoul, Herbrecht, Frédéric, Jacobs, Bérangère, Joly, Tarik, Kanouni, Alexandre, Lautrette, Véronique, Le Guern, Chantal, Loirat, Jean‐Paul, Mira, Bruno, Moulin, Christiane, Mousson, Mario, Ojeda Uribe, Abdelkader, Ouchenir, Nathalie, Parquet, Julie, Peltier, Pierre, Perez, Pascale, Poullin, Claire, Pouteil‐Noble, Claire, Presne, François, Provôt, Jean‐Antoine, Ribeil, Eric, Rondeau, Samir, Saheb, Benoît, Schlemmer, Amélie, Seguin, Alain, Stépanian, Jean‐Paul, Vernant, Agnès, Veyradier, Cécile, Vigneau, François, Vrtovsnick, Alain, Wynckel, Martine, Wolf, and Patricia, Zunic

Abstract

Cardiac involvement is a major cause of mortality in patients with thrombotic thrombocytopenic purpura (TTP). However, diagnosis remains underestimated and delayed, owing to subclinical injuries. Cardiac troponin‐I measurement (cTnI) on admission could improve the early diagnosis of cardiac involvement and have prognostic value.

Published
2015
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7. Common Variable Immunodeficiency Patient Classification Based on Impaired B Cell Memory Differentiation Correlates with Clinical Aspects

Author

Piqueras, B., Lavenu-Bombled, C., Galicier, L., Cruyssen, F.Bergeron-Van, Mouthon, L., Chevret, S., Debré, P., Schmitt, C., and Oksenhendler, E.

Abstract

Common variable immunodeficiency (CVID) is a very heterogeneous syndrome defined by impaired immunoglobulin production. The functional classification of CVID patients on the basis of in vitroimmunoglobulin production is time consuming and has never shown any predictive value. We propose a classification based on the quantitative repartition of naive/memory B cells according to the dual expression of IgD and CD27. Fifty-seven patients were categorized into three groups: Group MB2 (11 patients, 19%) with normal memory B cells; Group MB1 (19 patients, 33%) with defective switched memory (IgD−CD27+) but normal nonswitched memory B cells (IgD+CD27+); Group MB0 (27 patients, 47%) with almost no memory B cells. In addition, a downexpression of activation markers (CD25, CD21, CD80, CD86) on B cells characterized the group MB1 patients and was associated with an upexpression of activation markers (HLA-DR, CD95, CD57) on T cells. This classification correlates with some clinical aspects showing a higher prevalence of splenomegaly (16/27, 59%), lymphoid proliferation (13/27, 48%) and granulomatous disease (12/27, 44%) in group MB0. Splenomegaly was also frequent in group MB1 (8/19, 42%). In contrast, autoimmunity was observed with similar prevalence in all three groups. Moreover, by analyzing B cell phenotype, immunoglobulin transcript expression, and somatic mutations, we propose different putative mechanisms responsible for impaired B cell activation and memory differentiation in this syndrome.

Published
2003
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8. Dysimmunité paranéoplasique dans les tumeurs à cellules dendritiques folliculaires : au-delà du syndrome auto-immun multi-organe paranéoplasique

Author

Coignard, E., Lepelletier, C., Frumholtz, L., Boutboul, D., Galicier, L., Lazaridou, I., Jachiet, M., Demeret, S., Maisonobe, T., Psimaras, D., Bagot, M., Bouaziz, J.-D., and Cassius, C.

Abstract

Le syndrome auto-immun multi-organe paranéoplasique (SAMP) est une entité hétérogène caractérisée par une atteinte cutanéomuqueuse proche du pemphigus associée à d’autres atteintes au premier rang desquelles la myasthénie et la bronchiolite oblitérante. La cause est une auto-immunité dirigée contre des cibles moléculaires cutanées (en particulier les plakines), dans un contexte d’hémopathie ou de tumeur solide. Le spectre dermatologique peut associer des lésions de pemphigus vulgaire, de pemphigoïde bulleuse, de lichen plan et de GVH cutanée. Sa physiopathologie est encore mal comprise. Les tumeurs à cellules dendritiques folliculaires (TCDF) sont une forme très rare de tumeurs dérivées des CDF et peuvent être à l’origine d’un SAMP mais aussi d’autres manifestation auto-immunes.

Published
2020
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9. Acute generalized exanthematous pustulosis induced by hydroxychloroquine prescribed for COVID-19

Author

Delaleu, Jérémie, Deniau, Benjamin, Battistella, Maxime, de Masson, Adèle, Bensaid, Benoit, Jachiet, Marie, Lazaridou, Ingrid, Bagot, Martine, Bouaziz, Jean-David, Archer, G., Benattia, A., Bergeron, A., Bondeelle, L., Bouaziz, J.D., Bouda, D., Boutboul, D., Brindel, Berthon I., Bugnet, E., Caillat Zucman, S., Cassonnet, S., Celli Lebras, K., Chabert, J., Chevret, S., Clément, M., Davoine, C., De Castro, N., De Kerviler, E., De Margerie-Mellon, C., Delaugerre, C., Depret, F., Denis, B., Djaghout, L., Dupin, C., Farge-Bancel, D., Fauvaux, C., Feredj, E., Feyeux, D., Fontaine, J.P., Fremeaux-Bacchi, V., Galicier, L., Harel, S., AL, Jegu, Kozakiewicz, E., Lebel, M., Baye, A., Le Goff, J., Le Guen, P., Lengline, E., Liegeon, G., Lorillon, G., Madelaine Chambrin, I., Martin de Frémont, G., Meunier, M., Molina, J.M., Morin, F., Oksenhendler, E., Peffault de la Tour, R., Peyrony, O., Plaud, B., Salmona, M., Saussereau, J., and Soret, J.

Published
2020
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10. Lésions cutanées type Crohn associées au syndrome lymphoprolifératif lié à l’X de type 2

Author

Seta, V., Saussine, A., Galicier, L., Fieschi, C., Bagot, M., Bouaziz, J.-D., and Rybojad, M.

Abstract

Le syndrome lymphoprolifératif lié à l’X de type 2 (XLP-2) est une cause rare de déficit immunitaire primitif liée à une mutation du gène XIAP(X-linked inhibitor of apoptosis) décrit en 2006, classiquement défini par une triade : risque élevé de lymphohistiocytose hémophagocytique EBV induite, splénomégalie récidivante, atteinte inflammatoire de l’intestin pseudo-Crohn. Sur les plus de 70 cas rapportés, environ 7 % avaient une atteinte cutanée associée.

Published
2016
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12. Campylobacter infection in adult patients with primary antibody deficiency

Author

Dion, Jérémie, Malphettes, Marion, Bénéjat, Lucie, Mégraud, Francis, Wargnier, Alain, Boutboul, David, Galicier, Lionel, Le Moing, Vincent, Giraud, Patrick, Jaccard, Arnaud, Nove-Josserand, Raphaële, Fieschi, Claire, Oksenhendler, Eric, Gérard, Laurence, Oksenhendler, E., Fieschi, C., Malphettes, M., Galicier, L., Georgin, S., Fermand, J.P., Viallard, J.F., Jaccard, A., Hoarau, C., Lebranchu, Y., Bérezné, A., Mouthon, L., Karmochkine, M., Schleinitz, N., Durieu, I., Nove-Josserand, R., Chanet, V., Le-Moing, V., Just, N., Salanoubat, C., Jaussaud, R., Suarez, F., Hermine, O., Solal-Celigny, P., Hachulla, E., Condette-Wojtasik, G., Sanhes, L., Gardembas, M., Pellier, I., Tisserant, P., Pavic, M., Bonnotte, B., Haroche, J., Amoura, Z., Alric, L., Thiercelin, M.F., Tetu, L., Adoue, D., Bordigoni, P., Perpoint, T., Sève, P., Rohrlich, P., Pasquali, J.L., Soulas-Sprauel, P., Couderc, L.J., Giraud, P., Baruchel, A., Deleveau, I., Chaix, F., Donadieu, J., Tron, F., Larroche, C., Blanc, A.P., Masseau, A., Hamidou, M., Gorochov, G., Garnier, J.L., Moins, H., Fieschi, C., Malphettes, M., and Gérard, L.

Published
2019
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13. Pemphigus paranéoplasiques associés aux hémopathies : facteurs de risque de mortalité et de survie

Author

Ouedraogo, E.C., Gottlieb, J., De Masson, A., Lepelletier, C., Jachiet, M., Salle De Chou, C., Galicier, L., Bagot, M., Chevret, S., and Bouaziz, J.-D.

Abstract

Les pemphigus paranéoplasiques (PPN) sont plus associés à des hémopathies malignes (HM) qu’à des cancers solides. La bronchiolite oblitérante (BO) est une complication sévère du PPN.

Published
2018
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14. Association exceptionnelle d’un érythème noueux et d’un paragranulome de Poppema et Lennert

Author

Lepelletier, C., Galicier, L., Vignon-Pennamen, M.-D., Meignin, V., Battistella, M., Bagot, M., Rybojad, M., and Bouaziz, J.-D.

Abstract

Le paragranulome de Poppema et Lennert, ou maladie de Hodgkin nodulaire à prédominance lymphocytaire (MHNPL), est une entité rare, distincte de la maladie de Hodgkin classique. Nous décrivons ici un cas exceptionnel d’érythème noueux (EN) récidivant révélant une MHNPL.

Published
2015
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17. Localisation cutanée de lymphome de Burkitt : 3 cas et revue de la littérature

Author

Velter, C., de Masson, A., Galicier, L., Meignin, V., Gerard, L., Boutboul, D., Cuccuini, W., Feugeas, J.P., Oksenhendler, E., Bagot, M., Janin, A., and Battistella, M.

Abstract

Le lymphome de Burkitt est un lymphome B agressif. Les localisations cutanées de lymphome de Burkitt ont rarement été rapportées et leur intérêt pronostique n’est pas connu.

Published
2014
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