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Courtz continued dropping music while studying mechanical engineering in college, where he'd been recruited in track and field; eventually, releases like his slick four-song EP Invierno led to a record deal with Pitbull's Mr. 305 label. "YELLOWSTONE" FEVER EARLIER THIS YEAR, some of country music's most gifted songwriters, from Miranda Lambert and Aaron Raitiere to Sunny Sweeney and Jonathan Terrell, assembled on Nashville's Music Row to write songs for country and roots music's unexpected starmaker: Yellowstone. The upbeat love song, written and produced in collaboration with New Delhi-based singer-songwriter Bharg, quickly reached a million views on YouTube and boasts more than 4 million streams on Spotify - promising numbers for an artist who's still new on India's independent-music scene. "It's a shame the city let the soul of a downtown music scene that supported original songs slip away for a price tag.". [Extracted from the article]

While attending cosmetology school as a teen, Brooks discovered drag on Tumblr and would sneak out to see the drag luminary Chevelle Brooks perform at local gay clubs. T.M. NOLWEN CIFUENTES Mistress Isabelle Brooks "TRADITIONAL DRAG is a dying art form", says Mistress Isabelle Brooks, "and I feel like it's my job to keep it alive." Kerri Colby FOR KERRI COLBY, drag was like the wardrobe in The Chronicles of Narnia: Once she stepped inside that world, she could embrace who she truly was. [Extracted from the article]

The article features several up-and-coming leaders in the music industry as of June 2021. YellowHeart founder and chief executive officer (CEO) Josh Katz focused on cryptocurrency and blockchain to establish a more direct relationship between artists and fans. Other featured personalities include Asylum Records' Dallas Martin, Peloton's Gwen Bethel Riley, and Hillman Grad Records founder Lena Waithe.

The article features 10 up-and-coming musicians as of February 2021, including British pop musician Rina Sawayama, rapper Saint Jhn, and Puerto Rican Rauw Alejandro. Also cited are the growing popularity of singers like Teddy Swims, Canada's Allison Russell, and Benee of New Zealand, as well as the music of British singer-songwriter Anna B. Savage and singer Olivia Kaplan.

The article features singer-songwriter Joy Oladokun and her music. Topics discussed include her regular practice of meditating as her way of dealing with anxiety, her debut album "In Defense of My own Happiness," her life as a Nigerian immigrant in the U.S. as reflected in her album, and her love for rock music.

Background/aimsChronic heart failure is a common condition with a poor prognosis, and its prevalence is increasing in the UK and elsewhere. Patients with heart failure require complex multidisciplinary care, with appropriate medicines optimisation, nursing support and management of comorbidities, ideally delivered via a multidisciplinary team integrated between the community and the hospital. This study aimed to investigate how heart failure care services are structured and delivered.MethodsA survey of 100 health professionals in 79 heart failure centres was conducted by post or telephone using the same structured question format.ResultsThere was widespread variability in the provision of key elements of heart failure nursing (specialist heart failure nurses, nurse prescriber, nurse consultant). A total of 15% of trusts had no local consultant with special interest in heart failure; 73% had no pharmacist; and 83% had no mental health specialist working in the heart failure healthcare team. Dedicated administrative support was absent in 24% of trusts. One-fifth (20%) did not offer exercise rehabilitation. A total of 68% reported insufficient resources available locally for individualised exercise rehabilitation, in accordance with guidelines from the National Institute for Health and Care Excellence.ConclusionsThe structure and provision of heart failure care is variable across the UK, and not always consistent with current guidelines. Reducing this variability across the UK is an urgent priority and will require increased resources, especially for specialist nurses embedded within the routine care of patients with chronic heart failure.

AFTER FORMING at Columbia University, the boat-shoe-wearing blog-loved indie-pop crew toned down the sunny globe-trotting guitars of their 2008 debut and stared down quarter-life crisis with a broodingly lovely album of reflections on morality, God, uncertainty, and romantic decay; fittingly, they debuted Modern Vampire's first single, "Unbelievers", dressed as skeletons on late-night TV just days after Hurricane Sandy shut down New York, and on songs like "Diane Young" and "Hannah Hunt", Ezra Koenig turns the search for faint glints of redemption in his own emotional wreckage into a drama of Dylan-esque grandeur. More impressive was the way she made her sonic wanderlust feel urgent, sculpting some of her most immediate songs, like the vulnerable, shimmering "Kiss It Better" and the Drake duet "Work", and how she capped off the album with a smoldering run of modern torch ballads. RECORDED in a secrecy that made the Manhattan Project look like a chill hang, Beyoncé's self- titled fifth album was the mother of all surprise releases when it hit in 2013 - an especially insane feat since Beyoncé came with a blockbuster visual album as well. My favorite album of the 2010s was: Beyoncé's 4, just because it has one of my favorite songs of all time, "Countdown.". [Extracted from the article]

Then Bieber hopped on the remix and the most popular mostlyin- Spanish song ever was born. IN THE EARLY 2010s, as R&B artists chased the hip-hop and EDM zeitgeist, this California upstart showed up out of nowhere sounding like a singer from another era; Miguel exuded the style and grace of a Motown romantic on his plush debut slow jam, a song that felt sweetly old-school right down to its anachronistic-sounding title. Considering the song's almost scientifically pop precision, it's no surprise its recording involved reworking the song "four or five" times to nail "that euphoric feeling of having a teenage love, all over again". WHERE WE HEARD IT Early in the decade, singers inexplicably started yelling "Wa-oh-wa-oh" in their songs - Katy Perry on "California Gurls", Kesha on "Tik Tok", Frank Ocean on "Ivy.". [Extracted from the article]

Like a lot of queer performers in country and folk music, Housman is working mainly on his own, without the help of major firms or even indie labels. WHEN BRANDY CLARK launched a country-music recording career in 2013, there wasn't any template for an openly gay artist in Nashville. " Chris Housman is one of a newer generation of young country songwriters who takes inspiration from Clark's and McAnally's work. [Extracted from the article]

For decades, historians have debated the origins of Einstein’s special theory of relativity. The derivation of the Lorentz Transformations given by Einstein in 1905 is studied in detail; and it is found to be mathematically inconsistent, and thus in error. Therefore, he must have been aware of the transformations at the time of writing the paper, which is an extremely minority opinion in the general literature. His attempt to rederive them starting from the synchronization condition is incorrect. Though the derivation is flawed, it does not affect many of the concepts he put forth that flow from the Lorentz Transformations. The observations given here will help resolve a long-standing dispute over the priority of the discovery of various parts of the theory. The priority, which is presently concentrated with Einstein, may need to be redistributed between Einstein, Lorentz, Poincaré, Larmor, Voigt, and others.

Dehydrosqualene and squalene synthases catalyze the redox neutral and the reductive, head-to-head dimerization of farnesyl diphosphate, respectively. In each case, the reaction is thought to proceed via an initial dissociation of farnesyl diphosphate to form an allylic carbocation-pyrophosphate ion pair. This work describes the synthesis and testing of inhibitors in which a guanidinium or amidinium moiety is flanked by a phosphonylphosphinate group and a hydrocarbon tail. These functional groups bear a planar, delocalized, positive charge and therefore should act as excellent mimics of an allylic carbocation. An inhibitor bearing a neutral urea moiety was also prepared as a control. The positively charged inhibitors acted as competitive inhibitors against Staphylococcus aureusdehydrosqualene synthase with Kivalues in the low micromolar range. Surprisingly, the neutral urea inhibitor was the most potent of the three. Similar trends were seen with the first half reaction of human squalene synthase. One interpretation of these results is that the active sites of these enzymes do not directly stabilize the allylic carbocation via electrostatic or π-cation interactions. Instead, it is likely that the enzymes use tight binding to the pyrophosphate and lipid moieties to promote catalysis and that electrostatic stabilization of the carbocation is provided by the bound pyrophosphate product. An alternate possibility is that these inhibitors cannot bind to the “ionization FPP-binding site” of the enzyme and only bind to the “nonionizing FPP-binding site”. In either case, all reported attempts to generate potent inhibitors with cationic FPP analogues have been unsuccessful to date.

The article profiles several musicians, singers, and bands including singer Amara La Negra, the punk rock band Dream Wife, and rapper Saba.

On the single "Free Yourself", Ware flips into disco-diva mode with an anthem of sexual liberation for queer and straight people alike. Sometimes Ware just embraces the feeling of being unabashedly horny. The title track - co-penned by Ware - opens with an orgy of breathy voices uttering the title phrase before transforming into a limber disco-funk jam somewhere between Prince and Stevie Wonder. [Extracted from the article]

How many LGBTQ+ researchers are there in the United States? The National Science Foundation should find out.

The article discusses the ways to incorporate gardening in the home design to prevent unwanted lights from entring a house.

The Venue Group has plans to open a smaller club near downtown Huntsville, rounding out an ecosystem that now includes music stores like Vertical House and Tangled String Studios at Lowe Mill. ALABAMA SHAKING A world-class outdoor venue inspired by ancient Roman designs is probably the last thing you'd expect to find in Huntsville, Alabama, but the city's new ORION AMPHITHEATER is all about exceeding expectations. "Once I got it locked in, I was like, 'Man, this is what I wanted to show the people of Huntsville, what we're trying to achieve,'" says Ryan Murphy, GM of Orion and Huntsville Venue Group (a division of Lovett's TVG). [Extracted from the article]

The worst bit sounds like Pere Ubu doing ironic nightclub jazz. Black midi Hellfire Rough Trade BLACK SHITTY Once a very cool post-punk band, London's black midi take a serious detour into pretentious overreach here. [Extracted from the article]

PHOTO (BLACK & WHITE) Superorganism World Wide Pop Domino TOO-HYPER POP Psychedelic indie-pop crew Superorganism had a great hit a few years back with "Something for Your M.I.N.D." This fire hose of arch-pop cleverness will overload even the sharpest mind. [Extracted from the article]

Jack White Entering Heaven Alive Third Man LAID-BACK JACK White's second album of the year is a mostly acoustic set that reins in some of the zanier impulses of his recent work to make one of his more enjoyable LPs in a while. PHOTO (BLACK & WHITE). [Extracted from the article]

PHOTO (BLACK & WHITE) Tedeschi Trucks Band I Am the Moon Fantasy LONG HAUL This ambitious rock band is spreading its new 24-song release over a series of mini LPs, each worth your while; they make Southern-rock and classic-rock history seem present in our time. [Extracted from the article]

Amanda Shires Take It Like a Man ATO BIG COUNTRY One of Nashville's mostgifted singer-songwriters continues to expand her folk-based sound, mixing Radiohead-style atmospherics, Seventies pop melodies, and even a splash of soul. PHOTO (BLACK & WHITE). [Extracted from the article]

The article features masked country singer Orville Peck and his recording session with musicians at Neon Cross studio in East Nashville, Tennessee.

This study evaluated daytime alertness and performance with lisdexamfetamine dimesylate during acute sleep loss. In a randomized, double-blind study in healthy adult men (n = 135) undergoing 24-hour sleep loss, the alerting effects of single oral lisdexamfetamine dimesylate doses (20, 50, or 70 mg) were compared with a placebo and an active control (armodafinil 250 mg). Primary end point was mean unequivocal sleep latency on the 30-minute maintenance of wakefulness test taken every 2 hours from midnight to 8:00 A.M. Secondary end points included the Karolinska sleepiness scale and psychomotor vigilance task. Safety assessments included treatment-emergent adverse events (TEAEs) and vital signs. Least squares mean (SE) maintenance of wakefulness test unequivocal sleep latency (in minutes) was longer with lisdexamfetamine dimesylate 20, 50, and 70 mg, or armodafinil 250 mg (23.3 1.10, 27.9 0.64, 29.3 0.44, or 27.6 0.63, respectively) versus placebo (15.3 1.00; P< 0.0001). Longer mean unequivocal sleep latency was seen with lisdexamfetamine dimesylate 70 mg versus armodafinil (P= 0.0351) and armodafinil versus lisdexamfetamine dimesylate 20 mg (P= 0.0014). On Karolinska sleepiness scale, lisdexamfetamine dimesylate 50 and 70 mg improved estimated sleepiness versus placebo (P0.0002) and armodafinil (P0.03). Active treatments improved psychomotor vigilance task performance versus placebo (P< 0.0001). The TEAEs were mildmoderate. No serious adverse events occurred. The most common TEAE was headache with lisdexamfetamine dimesylate and armodafinil (7.4 each) versus placebo (3.7). Small mean increases in vital signs were observed with lisdexamfetamine dimesylate and armodafinil. In sleep-deprived healthy men, alertness was greater with lisdexamfetamine dimesylate and armodafinil versus placebo on the primary end point. Studies are needed in clinical populations and using longer durations of administration.

Palomino, Lambert's eighth solo album, is full of departures too. Reviews Music Miranda Lambert Palomino RCA Nashville Rated 4 out of 5 stars MIRANDA LAMBERT'S 2021 collaborative album The Marfa Tapes, with Jack Ingram and Jon Randall, was a stripped-down set that helped resituate the Texas-born Lambert in the tradition of Lone Star singer-songwriters like Guy Clark and Robert Earl Keen. [Extracted from the article]

We have designed template‐assembled synthetic proteins (TASPs) with the intent of controlling their oligomeric state by stabilizing specific helical tertiary structures via histidine metal ion chelation or disulfide incorporation. In solution, cavitein Q4 was previously determined to interconvert between a four‐helix bundle monomer and an eight‐helix bundle dimer. In this paper, we show that judicious mutation of cavitein Q4 can stabilize either the monomeric parallel four‐helix bundle or the dimeric antiparallel eight‐helix bundle structure. Cavitein Q4‐E3H, designed to be dimeric, is indeed biased toward dimerization as a result of incorporation of histidines. Moreover, the addition of nickel was found to further increase the association constant of dimerization. Similarly, a cavitein designed to stabilize the monomeric structure via histidine metal ion chelation (Q4‐H) was found to favor a monomer in solution upon addition of nickel. Lastly, a cavitein intended to stabilize a monomeric structure via disulfide incorporation (Q4‐C2) is reported. Surprisingly, this disulfide cavitein yielded two products upon oxidation suggesting disulfide formation both above the cavitand template and below may be possible. Nevertheless, the two disulfide caviteins were shown to exist as monomers as per their design.

A template‐assembled de novo four‐helix bundle is used to examine the hydrophobic effect within the bundle interior. Leu to Ala variants of the basis sequence GG‐EELLKKLEELLKKG were characterized by GuHCl denaturation, NMR dispersion, and N‐H/D exchange experiments. The results show that the middle leucine (L7) is imperative in maintaining bundle stability. The average leucine was found to contribute 1.8 kcal mol−1 toward stability, whereas the middle leucines contribute 2.7 kcal mol−1 each. Substituting alanine into the middle position (7) constitutes a striking 95% reduction of the overall cavitein stability. © 2007 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 88: 725–732, 2007.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com

Modified‐release (MR) zolpidem was developed to maintain effective plasma concentrations during the 3‐ to 6‐hour post‐dosage interval, corresponding to the middle portion of the typical sleep interval. Modified‐release zolpidem (12.5 mg), standard immediate‐release (IR) zolpidem (10 mg), and placebo were compared in a double‐blind, single‐dose, 3‐way crossover daytime study of healthy volunteers (n = 70 completers). Effect areas for electroencephalographic β amplitude during 0 to 8 hours and 3 to 6 hours after dosage were greater for MR compared to IR (P<.001). The digit‐symbol substitution test and sedation rating scales behaved similarly. MR and IR did not differ in effects at 8 hours post‐dosage nor in half‐life or clearance. Time of peak plasma concentration (tmax) was significantly longer for MR (2.4 vs 2.0 hours, P<.004), and dose‐normalized peak plasma concentration (Cmax) was lower (12.2 vs 14.0 ng/mL/mg, P<.001). MR zolpidem also had greater area under the plasma concentration curve (AUC) during the 3‐ to 6‐hour interval (P<.001). Thus, MR zolpidem produces sustained plasma levels compared to IR, with resulting enhancement of pharmacodynamic effects in the 3‐ to 6‐hour post‐dosage interval.

There is a paucity of empirical data establishing the efficacy of electroconvulsive therapy (ECT) in patients with mental retardation and psychiatric disorders. This study examines the efficacy of ECT on specific symptoms and between psychiatric diagnoses in patients with mental retardation who are psychiatrically ill. A chart review was performed on 20 inpatients who had received ECT on a dedicated Mental Retardation-Dual Diagnosis Unit and were divided into 3 categories: mood disorders (n = 12), psychotic disorders (n = 6), and intermittent explosive disorder (n = 2). Ratings were performed 1 week before ECT treatment and 1-week after its termination using the Aberrant Behavior Checklist and the Clinical Global Impressions Severity Scale. A repeated-measures analysis of variance comparing Aberrant Behavior Checklist scale scores revealed a significant time-by-treatment interaction (F = 75.43, df = 1,9, P= 0.000, 2 t). The mood disorder and psychotic disorder groups had significantly lower irritability and hyperactivity scores after treatment compared with the intermittent explosive disorder group. The Clinical Global Impressions Severity Scale rating scores showed significant improvement in the mood disorders group (67%), in contrast to the intermittent explosive disorder group (0%). Our data suggests the utility of ECT for patients with mental retardation who also have treatment-resistant mood disorders and psychotic disorders, particularly with symptoms of hyperactivity and irritability. The data are sufficiently encouraging to justify prospective research of this question.

In a study of acute sleep deprivation in healthy male volunteers randomized to double-blind treatment with lisdexamfetamine dimesylate (20, 50, or 70 mg), placebo control, or an active control (armodafinil 250 mg), Maintenance of Wakefulness Test data were compared using a generalized estimating equation analysis to eliminate the need for unequivocal sleep latency imputation. Compared with placebo across all Maintenance of Wakefulness Tests, all active treatments were associated with lower risk of falling asleep (risk ratio 95 confidence interval): 0.45 (0.27–0.76; P= 0.0026), 0.10 (0.05–0.20; P< 0.0001), and 0.05 (0.02–0.14; P< 0.0001) for 20, 50, and 70 mg lisdexamfetamine dimesylate, respectively, and 0.11 (0.06–0.21; P< 0.0001) for the active control. Sleep-risk ratios were similar for lisdexamfetamine dimesylate 50 or 70 mg and for the active control, but lisdexamfetamine 20 mg was associated with a greater risk of falling asleep compared with the active control (4.13 1.97–8.67; P= 0.0002). Generalized estimating equation analysis detected wake-promoting effects of active treatments and eliminating data imputation, suggesting model utility in future studies.

This study examined whether patients with major depressive disorder manifest deficits in intelligence during affective episodes and following clinical improvement. WAIS-R scores were contrasted in 100 patients in an episode of major depression with 50 normal controls, matched to the patient sample in terms of demographic variables and estimates of premorbid IQ. The groups were equivalent in verbal IQ, but, in line with previous studies, the depressed patients had a pronounced deficit in performance IQ. A patient subsample was administered the WAIS-R under unlimited time conditions to determine whether the time constraints of performance IQ subtests contributed to the magnitude of the verbal-performance IQ discrepancy. This discrepancy was only slightly reduced with untimed scoring. Subgroups of depressed patients were retested with the WAIS-R within one week (n = 26) or two months (n = 33) following treatment with electroconvulsive therapy. In both subsamples, IQ scores were improved at posttreatment testing relative to pretreatment, but with little change in the verbal-performance IQ discrepancy. These and related findings suggested that a performance IQ deficit is characteristic of depressed patients regardless of affective state.

The article profiles Nashville, Tennessee-based singers and married couple Jason Isbell and Amanda Shires, dealing with topics including his prior work in the band Drive-By Truckers and her new LP, "To the Sunset."

We propose an inexpensive novel rapid prototyping approach to a maskless and fully adaptive photolithographic process. Phase-only computer-generated holograms of lithographic masks displayed on a liquid-crystal-on-silicon spatial light modulator were used in a holographic optical lithography system. Using holographic projection allows diffraction-limited performance within the given parameters of the optical system, adaptive software refocusing, and a continuous, pixel-free pattern. With the demonstrator, we have successfully proven the concept for micrometer-size lithographic features.

The article features Kentucky singer-songwriter S. G. Goodman.

After being featured in Netflix rom-com Someone Great, "Truth Hurts" became the summer's most unstoppable breakup anthem, and with punchlines like "You're 'posed to hold me down, but you're holding me back/And that's the sound of me not calling you back", a self-love declaration for the ages. LIKE SO MANY songs in the Swift's pantheon, "Cruel Summer" rides the knife edge of a crush - reckless, anticipating the crash, but consumed by the feeling. "I FEEL THIS is the first time there is pure Afro-beats from Nigeria in the pop scene", Nigerian singer Mr Eazi said of "Como Un Bebe", his killer collaboration with Bad Bunny and Colombian reggaeton king J Balvin. [Extracted from the article]