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2. DSM-5 Criterion-A-Based Trauma Types in Service Members and Veterans Seeking Treatment for Posttraumatic Stress Disorder.

Author

Benfer, Natasha, Grunthal, Breanna, Dondanville, Katherine A., Young-McCaughan, Stacey, Blankenship, Abby, Abdallah, Chadi G., Back, Sudie E., Flanagan, Julianne, Foa, Edna B., Fox, Peter T., Krystal, John H., Marx, Brian P., McGeary, Donald D., McLean, Carmen P., Pruiksma, Kristi E., Resick, Patricia A., Roache, John D., Shiroma, Paulo, Sloan, Denise M., and Taylor, Daniel J.

Published
2024
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6. Efficacy and moderators of efficacy of cognitive behavioural therapies with a trauma focus in children and adolescents: an individual participant data meta-analysis of randomised trials

Author

de Haan, Anke, Meiser-Stedman, Richard, Landolt, Markus A, Kuhn, Isla, Black, Melissa J, Klaus, Kristel, Patel, Shivam D, Fisher, David J, Haag, Christina, Ukoumunne, Obioha C, Jones, Benjamin G, Flaiyah, Ashraf Muwafaq, Catani, Claudia, Dawson, Katie, Bryant, Richard A, de Roos, Carlijn, Ertl, Verena, Foa, Edna B, Ford, Julian D, Gilboa-Schechtman, Eva, Tutus, Dunja, Hermenau, Katharin, Hecker, Tobias, Hultmann, Ole, Axberg, Ulf, Jaberghaderi, Nasrin, Jensen, Tine K, Ormhaug, Silje M, Kenardy, Justin, Lindauer, Ramon J L, Diehle, Julia, Murray, Laura K, Kane, Jeremy C, Peltonen, Kirsi, Kangaslampi, Samuli, Robjant, Katy, Koebach, Anke, Rosner, Rita, Rossouw, Jaco, Smith, Patrick, Tonge, Bruce J, Hitchcock, Caitlin, and Dalgleish, Tim

Abstract

Existing clinical trials of cognitive behavioural therapies with a trauma focus (CBTs-TF) are underpowered to examine key variables that might moderate treatment effects. We aimed to determine the efficacy of CBTs-TF for young people, relative to passive and active control conditions, and elucidate putative individual-level and treatment-level moderators.

Published
2024
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7. Entangled States Induced by Electron–Phonon Interaction in Two-Dimensional Materials

Author

Mella, José D., Calvo, Hernán L., and Foa Torres, Luis E. F.

Abstract

We report on the effects of electron–phonon interaction in materials such as graphene, showing that it enables the formation of a gap bridged by unique edge states. These states exhibit a distinctive locking among propagation direction, valley, and phonon mode, allowing for the generation of electron–phonon entangled states whose parts can be easily split. We discuss the effect of the chiral atomic motion in the zone boundary phonons leading to this effect. Our findings shed light on how to harness these unconventional states in quantum research.

Published
2023
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8. Brief Imaginal Exposure for PTSD: Trajectories of Change in Distress.

Author

Zoellner, Lori A., Lehinger, Elizabeth A., Rosencrans, Peter L., Cornell-Maier, Sarah M., Foa, Edna B., Telch, Michael J., Gonzalez-Lima, Francisco, and Bedard-Gilligan, Michele A.

Subjects
PSYCHOLOGICAL distress, POST-traumatic stress disorder, EPISODIC memory, INDIVIDUALIZED medicine, MEDICAL protocols
Abstract

• Brief daily imaginal exposure only can be an effective treatment for PTSD. • Distress during imaginal exposure decreased linearly and predicted better outcome. • Mechanism of action may mirror extinction processes seen in full prolonged exposure. • Clinically, daily sessions may build on one another and facilitate gains. • Viable option for settings where brief PTSD treatment is needed. Preliminary evidence shows that brief, condensed imaginal exposure only interventions can be effective in the treatment of PTSD, but we need to understand its mechanisms of action. Consistent with extinction learning and retrieval processes, the present study examined whether a pattern of between-session distress reduction observed during standard prolonged exposure (PE) therapy would be observed and predict outcome. Sixty-three patients with PTSD were enrolled in two clinical trials using our treatment protocol consisting of six daily 50-min sessions focusing on imaginal exposure and processing only. Individual patient trajectories of distress reduction were examined over the course of the five imaginal exposure sessions (Sessions 2-6). Overall, significant linear distress reduction was observed for anticipatory (d = 1.18), peak (d = 1.83), and ending imaginal exposure distress (d = 1.21). Consistent with extinction learning, the steeper slope of peak distress (d = 1.03) and end distress (d = 0.68) across imaginal exposure sessions strongly predicted decreases in PTSD symptoms. Distress reduction across sessions was predicted by higher baseline avoidance and hyperarousal but not reexperiencing symptoms. This condensed format of daily 50-min sessions without in vivo exposure may be operating via similar extinction learning processes as longer protocols. Our clinical observations suggest that the brief daily format may offer the advantage of allowing each session to build on the previous one to promote meaningful shifts in the retrieval of the trauma memory. Brief imaginal exposure and processing may be a viable option for PTSD patients in settings where brief interventions are needed. Understanding potential change processes and baseline predictors of change brings us closer toward precision medicine in treating PTSD. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Prevalence of Fibromyalgia Syndrome in Active‐DutyMilitary Personnel

Author

Lawrence‐Wolff, Katrina M., Higgs, Jay B., Young‐McCaughan, Stacey, Mintz, Jim, Foa, Edna B., Resick, Patricia A., Kelly, Kevin M., Maurer, Douglas M., Borah, Adam M., Yarvis, Jeffrey S., Litz, Brett T., Hildebrand, Bernard A., Williamson, Douglas E., and Peterson, Alan L.

Abstract

Previous research with civilian populations has found strong associations between fibromyalgia (FM) and posttraumatic stress disorder (PTSD). We undertook this study to investigate the prevalence of FM in military service members with and without PTSD. Participants were active duty military personnel recruited into either an epidemiologic cohort study of service members before a military deployment or 1 of 3 PTSD treatment trials. Instruments used to document FM and PTSD included the PTSD Checklist–Stressor‐Specific Version, the PTSD Symptom Scale‐Interview, and the 2012 American College of Rheumatology FM questionnaire. Across the 4 studies, 4,376 subjects completed surveys. The prevalence of FM was 2.9% in the predeployment cohort, and the prevalence was significantly higher in individuals with PTSD (10.8%) compared with those without PTSD (0.8%). In the treatment trials, all of the participants met criteria for PTSD before starting treatment, and the prevalence of FM was 39.7%. The prevalence of FM in active duty service members preparing to deploy is similar to that reported for the general population of the US but is higher than expected for a predominantly male cohort. Furthermore, the prevalence of FM was significantly higher in service members with comorbid PTSD and was highest among those seeking treatment for PTSD. Further investigation is needed to determine the factors linking PTSD and FM.

Published
2023
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11. Intensive Outpatient Program Using Prolonged Exposure for Combat-Related PTSD: A Case Study.

Author

Straud, Casey L., Blount, Tabatha H., Foa, Edna B., Brown, Lily A., McLean, Carmen P., McGeary, Cindy A., Koch, Lauren M., Schobitz, Richard P., and Peterson, Alan L.

Subjects
MILITARY personnel, POST-traumatic stress disorder, EXPOSURE therapy, VETERANS, MILITARY culture
Abstract

• PE can be effectively adapted to an intensive outpatient format. • IOP-PE can result in clinically significant reductions in PTSD over time. • Addressing multiple traumatic events may increase processing and new learning. • Feedback and booster sessions may help to enhance and maintain treatment gains. • Incorporation of significant others may mitigate accommodating behaviors. Although prolonged exposure (PE) has been identified as a first-line treatment for posttraumatic stress disorder (PTSD), research has found that military service members and veterans have smaller reductions in symptom severity compared to civilians. The nature of trauma in a deployed combat setting and the unique complexities of military culture have been proposed as explanations for greater rates of PTSD and poorer treatment response to first-line psychotherapies in military and veteran populations. This paper presents a case study to highlight how a novel, intensive outpatient program utilizing prolonged exposure therapy (IOP-PE) may benefit military personnel with combat-related PTSD. The patient is a Caucasian man in his early 40s seeking treatment for PTSD after more than 10 years of enlisted, active duty military service across two branches and three combat deployments. The IOP-PE includes the standard PE components and eight, nonstandard treatment augmentations tailored for military personnel. In contrast to standard PE, which typically is delivered weekly over several months, IOP-PE consists of 15 daily, 90-minute PE sessions conducted over 3 weeks. The patient demonstrated large reductions on the Clinician-Administered PTSD Scale (28 points) and PTSD Checklist (48 points) by the 6-month posttreatment follow-up point. Findings provide support for conducting further research that determines whether IOP-PE is effective and tolerable in military and veteran populations. [ABSTRACT FROM AUTHOR]

Published
2022
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12. The Efficacy of 90-Min Versus 60-Min Sessions of Prolonged Exposure for PTSD: A Randomized Controlled Trial in Active-Duty Military Personnel.

Author

Foa, Edna B., Bredemeier, Keith, Acierno, Ron, Rosenfield, David, Muzzy, Wendy, Tuerk, Peter W., Zandberg, Laurie J., Hart, Stephanie, Young-McCaughan, Stacey, Peterson, Alan L., and McLean, Carmen P.

Subjects
COURTS-martial & courts of inquiry, MILITARY personnel, RANDOMIZED controlled trials, POST-traumatic stress disorder, MENTAL illness
Abstract

Objective: Prolonged exposure (PE) therapy is a first-line posttraumatic stress disorder (PTSD) treatment, but the manualized 90-min session format constitutes a barrier to adopting PE in most settings because they use 60-min sessions for scheduling and billing. We examined whether 60-min PE sessions were as effective and efficient as 90-min PE sessions. Method: In total, 160 active-duty military personnel with PTSD were randomized to 8–15 sessions of 60- or 90-min PE sessions and assessed pre- and posttreatment, and 3- and 6-month posttreatment, using the Clinician Administered PTSD Scale for Diagnostic and Statistical Manual for Mental Disorders, 5th edition [DSM-5] (CAPS-5). Participants were also assessed weekly during treatment using the PTSD Checklist for DSM-5 (PCL-5). A 60-min PE was hypothesized to be noninferior to 90-min PE based on preliminary studies. Results: Using intent-to-treat analyses, the 95% CI for the difference between 60- and 90-min PE was less than the noninferiority margin (4.69 for the CAPS-5 and 7.38 for the PCL-5) at all three endpoints, suggesting that the efficacy of 60-min PE was noninferior to that of 90-min PE. Similarly, the rate of improvement per session for 60-min PE was noninferior to the rate for 90-min sessions for the PCL-5. Sensitivity analyses and Bayes factors were consistent with these results. Conclusions: 60-min sessions of PE are noninferior to 90-min sessions with regard to both efficacy and efficiency. Thus, PE can be effectively delivered in shorter sessions, making it easier for behavioral health providers to implement within the military health system and in other mental health systems that use 60-min session appointments. What is the public health significance of this article?: The 60- and 90-min sessions of PE had comparable efficacy and efficiency in reducing PTSD symptoms. The implementation of shorter sessions of PE may increase access to evidence-based PTSD care. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Maintenance of Wellness in Patients With Obsessive-Compulsive Disorder Who Discontinue Medication After Exposure/Response Prevention Augmentation: A Randomized Clinical Trial.

Author

Foa, Edna B., Simpson, Helen Blair, Gallagher, Thea, Wheaton, Michael G., Gershkovich, Marina, Schmidt, Andrew B., Huppert, Jonathan D., Imms, Patricia, Campeas, Raphael B., Cahill, Shawn, DiChiara, Christina, Tsao, Steven D., Puliafico, Anthony, Chazin, Daniel, Asnaani, Anu, Moore, Kelly, Tyler, Jeremy, Steinman, Shari A., Sanches-LaCay, Arturo, and Capaldi, Sandy

Subjects
OBSESSIVE-compulsive disorder, CLINICAL trials, HAMILTON Depression Inventory, TIC disorders, SEROTONIN uptake inhibitors, ACADEMIC medical centers, DIAGNOSIS of obsessive-compulsive disorder, RESEARCH, RESEARCH methodology, BEHAVIOR therapy, EVALUATION research, TREATMENT effectiveness, COMPARATIVE studies, RANDOMIZED controlled trials, QUESTIONNAIRES, RESEARCH funding, COMBINED modality therapy
Abstract

Importance: Serotonin reuptake inhibitors (SRIs) are the only medications approved for obsessive-compulsive disorder (OCD), yet most patients taking SRIs exhibit significant symptoms. Adding exposure/response prevention (EX/RP) therapy improves symptoms, but it is unknown whether patients maintain wellness after discontinuing SRIs.Objective: To assess whether patients with OCD who are taking SRIs and have attained wellness after EX/RP augmentation can discontinue their SRI with noninferior outcomes compared with those who continue their SRI therapy.Design, Setting, and Participants: A 24-week, double-blind, randomized clinical trial was performed from May 3, 2013, to June 25, 2018. The trial took place at US academic medical centers. Participants included 137 adults with a principal diagnosis of OCD (≥1 year) who were taking an SRI (≥12 weeks), had at least moderate symptoms (defined as Yale-Brown Obsessive-Compulsive Scale [Y-BOCS] score ≥18 points), and received as many as 25 sessions of EX/RP therapy. Those who attained wellness (Y-BOCS score ≤14 points; 103 patients [75.2%]) were study eligible. Data were analyzed from June 29, 2019, to October 2, 2021.Intervention: Participants were randomly assigned either to receive taper to placebo (taper group) or to continue their SRI (continuation group) and monitored for 24 weeks.Main Outcome and Measures: The Y-BOCS score (range, 0-40 points) was the primary outcome; the Hamilton Depression Rating Scale (HDRS; range, 0-52 points) and the Quality-of-Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF; range, 0%-100%) scores were secondary outcomes. Outcomes were assessed at 8 time points by independent evaluators who were blinded to randomization. The taper regimen was hypothesized to be noninferior to continuation at 24 weeks using a 1-sided α value of .05.Results: A total of 101 patients (mean [SD] age, 31.0 [11.2] years; 55 women [54.5%]) participated in the trial: 51 patients (50.5%) in the taper group and 50 patients (49.5%) in the continuation group. At 24 weeks, patients in the taper group had noninferior results compared with patients in the continuation group (mean [SD] Y-BOCS score: taper group, 11.47 [6.56] points; continuation group: 11.51 [5.97] points; difference, -0.04 points; 1-sided 95% CI, -∞ to 2.09 points [below the noninferiority margin of 3.0 points]; mean [SD] HDRS score: taper group, 5.69 [3.84] points; continuation group, 4.61 [3.46] points; difference, 1.08 points; 1-sided 95% CI, -∞ to 2.28 points [below the noninferiority margin of 2.5 points]; mean [SD] Q-LES-Q-SF score: taper group, 68.01% [15.28%]; continuation group, 70.01% [15.59%]; difference, 2.00%; 1-sided 95% CI, -∞ to 6.83 [below the noninferiority margin of 7.75]). However, the taper group had higher rates of clinical worsening (23 of 51 [45%] vs 12 of 50 [24%]; P = .04).Conclusions and Relevance: Results of this randomized clinical trial show that patients with OCD who achieve wellness after EX/RP therapy could, on average, discontinue their SRI with noninferior outcomes compared with those who continued their SRI. Those who tapered the SRI had higher clinical worsening rates. Future research should evaluate if SRI half-life alters these rates.Trial Registration: ClinicalTrials.gov Identifier: NCT01686087. [ABSTRACT FROM AUTHOR]

Published
2022
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14. Neurocognitive Predictors of Treatment Outcomes in Psychotherapy for Comorbid PTSD and Substance Use Disorders.

Author

Scott, J. Cobb, Lynch, Kevin G., Cenkner, David P., Kehle-Forbes, Shannon M., Polusny, Melissa A., Gur, Ruben C., Chen, Shirley, Foa, Edna B., and Oslin, David W.

Subjects
POST-traumatic stress disorder, PSYCHOTHERAPY, EXECUTIVE function, SUBSTANCE abuse, TREATMENT effectiveness, VERBAL memory
Abstract

Objective: Comorbidity between posttraumatic stress disorder (PTSD) and substance use disorders (SUD) is common, and both are associated with cognitive dysfunction. However, few studies examine the impact of cognitive deficits on treatment outcomes. Here, we leverage data from a randomized clinical trial of integrated versus phased psychotherapy for SUD and PTSD to examine the relation of cognitive functioning to treatment response. Method: One-hundred and thirteen veterans with co-occurring PTSD and SUD completed Penn Computerized Neurocognitive Battery tests assessing attention, executive control, memory, and spatial processing. Linear mixed-effects models examined interactions between cognitive functioning and time in predicting primary PTSD and SUD outcomes across both treatments. Results: Significant verbal immediate memory by time interactions were found for both PTSD symptoms (p =.01, f2 = 0.020) and percent heavy drinking or drug use days (p =.004, f2 = 0.020). There was a significant working memory by time interaction for percent heavy drinking or drug use days (p =.007, f2 = 0.016). Participants with better verbal memory had greater reductions across time in PTSD symptoms and drinking/drug use, while those with better working memory had lesser reductions in their drinking/drug use across time. Conclusions: Individuals with lower verbal memory functioning had less robust PTSD and SUD symptom reductions in PTSD/SUD psychotherapy, with differences that were generally small in magnitude. Those with better working memory functioning had worse SUD outcomes. Together with prior literature, findings suggest that neurocognitive functioning may impact the effectiveness of PTSD and SUD treatment. What is the public health significance of this article?: This study suggests that psychotherapy for veterans with PTSD and substance use disorders may be less effective in individuals with lower verbal memory functioning. [ABSTRACT FROM AUTHOR]

Published
2021
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15. Conducting Prolonged Exposure for PTSD During the COVID-19 Pandemic: Considerations for Treatment.

Author

Fina, Brooke A., Wright, Edward C., Rauch, Sheila A.M., Norman, Sonya B., Acierno, Ron, Cuccurullo, Lisa-Ann J., Dondanville, Katherine A., Moring, John C., Brown, Lily A., and Foa, Edna B.

Subjects
COVID-19 pandemic, POST-traumatic stress disorder, SOCIAL distancing, PSYCHOLOGICAL stress, EMDR (Eye-movement desensitization & reprocessing), MENTAL health, SOCIAL isolation
Abstract

• The impact of the COVID-19 pandemic may be especially potent for individuals with PTSD. • PE is a well-established and efficacious treatment for PTSD. • Clinical practice strategies aid in implementation of PE during the COVID-19 pandemic. The unprecedented effects and duration of the COVID-19 crisis are likely to elevate the population's level of anxiety due to psychological stress, economic hardship, and social isolation. This effect may be especially potent for individuals with preexisting mental health conditions, such as posttraumatic stress disorder (PTSD). Prolonged Exposure (PE) therapy is a highly effective treatment for PTSD across trauma-exposed populations, and has been implemented effectively via telehealth. Nevertheless, PE implementation via telehealth may require specific adaptations during the COVID-19 crisis due to public health mandates calling for sheltering in place and physical distancing. This paper discusses strategies for implementing PE for PTSD during the COVID-19 pandemic, which may also be applied to other situations in which physical distancing must be considered. [ABSTRACT FROM AUTHOR]

Published
2021
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17. Moral Injury and Moral Healing in Prolonged Exposure for Combat-Related PTSD: A Case Study.

Author

Evans, Wyatt R., Russell, Laurie H., Hall-Clark, Brittany N., Fina, Brooke A., Brown, Lily A., Foa, Edna B., Peterson, Alan L., and For the Consortium to Alleviate PTSD

Subjects
HARM (Ethics), POST-traumatic stress disorder, MILITARY personnel, HEALING, WHIPLASH injuries, SYMPTOMS
Abstract

• Prolonged Exposure (PE) may be targeted to facilitate moral healing in the course of PTSD treatment. • Emergent conceptualizations of moral injury are compatible with the PE model. • In vivo and imaginal exposure procedures may be expanded to meet patient needs. • This case example demonstrates positive functional outcomes in a soldier with PTSD and moral injury. Prolonged Exposure (PE) is a highly effective treatment for posttraumatic stress disorder (PTSD) across a variety of delivery formats and samples. However, for military service members, the treatment tends to be less effective than for civilians. One explanation for the reduced response to PE in military service members is the frequency, intensity, and heterogeneity of combat trauma. Combat trauma may yield a variety of posttraumatic responses, including moral injury, or the psychosocial-spiritual suffering consequent of exposure to moral injurious events. Despite rapidly increasing research on combat-related moral injury, little clinical guidance exists on how or if moral injury may be addressed via trauma-focused treatments such as PE. This case report describes the facilitation of moral healing for a U.S. Army soldier with combat-related PTSD in a 3-week intensive outpatient PE program. While PTSD symptoms were reduced from pre- to posttreatment, even more substantial treatment gains were observed in the soldier's functional changes, engagement with values-based activities, and his reported willingness to embrace moral pain. Although not explicit in the PE manual, targeting these latter outcomes in PE can facilitate moral healing in service members with PTSD. This case report provides a detailed description of how PE procedures were targeted to address moral injury and where theory-driven augmentations were included to facilitate moral healing. [ABSTRACT FROM AUTHOR]

Published
2021
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18. Successful treatment of acute spleno-porto-mesenteric vein thrombosis after ChAdOx1 nCoV-19 vaccine. A case report

Author

Umbrello, Michele, Brena, Nicola, Vercelli, Ruggero, Foa, Riccardo Alessandro, Femia, Marco, Rossi, Umberto, Podda, Gian Marco, Cortellaro, Francesca, and Muttini, Stefano

Abstract

Several cases of deep venous thrombosis in people who had recently received Vaxzevria (previously known as COVID-19 Vaccine AstraZeneca) have recently been reported, mainly presenting as cerebral vein/cerebral venous sinus thrombosis. This syndrome has been termed “vaccine-induced immune thrombotic thrombocytopenia (VITT)”. Acute spleno-porto-mesenteric vein thrombosis is an uncommon but serious condition with potential sequelae, such as small-bowel gangrene and end-stage liver failure. We describe a case of concomitant thrombosis of portal, superior mesenteric and splenic veins in a young female patient with no other risk factors who received Vaxzevria (previously ChAdOx1 nCoV-19 vaccine, AstraZeneca) 17 days before. The diagnostic workup and the successful endovascular treatment and systemic anticoagulation management is reported.

Published
2021
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20. Review of current intracranial aneurysm flow diversion technology and clinical use

Author

Dandapat, Sudeepta, Mendez-Ruiz, Alan, Martínez-Galdámez, Mario, Macho, Juan, Derakhshani, Shahram, Foa Torres, Gustavo, Pereira, Vitor M, Arat, Anil, Wakhloo, Ajay K, and Ortega-Gutierrez, Santiago

Abstract

Endovascular treatment of intracranial aneurysms (IAs) has evolved considerably over the past decades. The technological advances have been driven by the experience that coils fail to completely exclude all IAs from the blood circulation, the need to treat the diseased parent vessel segment leading to the aneurysm formation, and expansion of endovascular therapy to treat more complex IAs. Stents were initially developed to support the placement of coils inside wide neck aneurysms. However, early work on stent-like tubular braided structure led to a more sophisticated construct that then later was coined as a flow diverter (FD) and found its way into clinical application. Although FDs were initially used to treat wide-neck large and giant internal carotid artery aneurysms only amenable to surgical trap with or without a bypass or endovascular vessel sacrifice, its use in other types of IAs and cerebrovascular pathology promptly followed. Lately, we have witnessed an explosion in the application of FDs and subsequently their modifications leading to their ubiquitous use in endovascular therapy. In this review we aim to compile the available FD technology, evaluate the devices’ peculiarities from the authors’ perspective, and analyze the current literature to support initial and expanded indications, recognizing that this may be outdated soon.

Published
2021
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21. Impact of exogenous estradiol on task-based and resting-state neural signature during and after fear extinction in healthy women

Author

Wen, Zhenfu, Hammoud, Mira Z., Scott, J. Cobb, Jimmy, Jagan, Brown, Lily, Marin, Marie-France, Asnaani, Anu, Gur, Ruben C., Foa, Edna B., and Milad, Mohammed R.

Abstract

Fluctuations of endogenous estrogen modulates fear extinction, but the influence of exogenous estradiol is less studied. Moreover, little focus has been placed on the impact of estradiol on broad network connectivity beyond the fear extinction circuit. Here, we examined the effect of acute exogenous estradiol administration on fear extinction-induced brain activation, whole-brain functional connectivity (FC) during the fear extinction task and post-extinction resting-state. Ninety healthy women (57 using oral contraceptives [OC], 33 naturally cycling [NC]) were fear conditioned on day 1. They ingested an estradiol or placebo pill prior to extinction learning on day 2 (double-blind design). Extinction memory was assessed on day 3. Task-based functional MRI data were ascertained on days 2 and 3 and resting-state data were collected post-extinction on day 2 and pre-recall on day 3. Estradiol administration significantly modulated the neural signature associated with fear extinction learning and memory, consistent with prior studies. Importantly, estradiol administration induced significant changes in FC within multiple networks, including the default mode and somatomotor networks during extinction learning, post-extinction, and during extinction memory recall. Exploratory analyses revealed that estradiol impacted ventromedial prefrontal cortex (vmPFC) activation and FC differently in the NC and OC women. The data implicate a more diffused and significant effect of acute estradiol administration on multiple networks. Such an effect might be beneficial to modulating attention and conscious processes in addition to engaging neural processes associated with emotional learning and memory consolidation.

Published
2021
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22. Bortezomib, thalidomide, and dexamethasone followed by double autologous haematopoietic stem-cell transplantation for newly diagnosed multiple myeloma (GIMEMA-MMY-3006): long-term follow-up analysis of a randomised phase 3, open-label study

Author

Tacchetti, Paola, Pantani, Lucia, Patriarca, Francesca, Petrucci, Maria Teresa, Zamagni, Elena, Dozza, Luca, Galli, Monica, Di Raimondo, Francesco, Crippa, Claudia, Boccadoro, Mario, Barbato, Simona, Tosi, Patrizia, Narni, Franco, Montefusco, Vittorio, Testoni, Nicoletta, Spadano, Antonio, Terragna, Carolina, Pescosta, Norbert, Marzocchi, Giulia, Cellini, Claudia, Galieni, Piero, Ronconi, Sonia, Gobbi, Marco, Catalano, Lucio, Lazzaro, Antonio, De Sabbata, Giovanni, Cangialosi, Clotilde, Ciambelli, Fabrizio, Musto, Pellegrino, Elice, Francesca, Cavo, Michele, Cavo, Michele, Fanin, Renato, Foa', Roberto, Rambaldi, Alessandro, Di Raimondo, Francesco, Rossi, Giuseppe, Boccadoro, Mario, Leoni, Pietro, Corradini, Paolo, Torelli, Giuseppe, Fioritoni, Giuseppe, Cortelazzo, Sergio, Lambertenghi Deliliers, Giorgio, La Nasa, Giorgio, Zaccaria, Alfonso, De Fabritiis, Paolo, Cascavilla, Nicola, Bosi, Alberto, Semenzato, Gianpietro, Gugliotta, Luigi, Gherlinzoni, Filippo, Angelucci, Emanuele, Martelli, Massimo Fabrizio, Petti, Maria Concetta, Leone, Giuseppe, Carella, Angelo Michele, Ciceri, Fabio, Santoro, Armando, Ferrara, Felicetto, Nobile, Francesco, D'Arco, Alfonso Maria, Levis, Alessandro, Guardigni, Luciano, Gallamini, Andrea, Musto, Pellegrino, Fattori, Pier Paolo, Galieni, Piero, Morandi, Sergio, Amadori, Dino, Gobbi, Marco, Rotoli, Bruno, Mirto, Salvatore, Lazzaro, Antonio, Paladini, Giorgio, Mozzana, Ruggero, Pinotti, Graziella, Rodeghiero, Francesco, Cantore, Nicola, Pavone, Vincenzo, Pogliani, Enrico Maria, Liberati, Anna Marina, Majolino, Ignazio, Amadori, Sergio, Lauria, Francesco, Aglietta, Massimo, Quarta, Giovanni, Storti, Sergio, Morabito, Fortunato, Capalbo, Silvana Franca, Gianni, Alessandro Massimo, Mettivier, Vincenzo, Rizzoli, Vittorio, Bernasconi, Carlo, Visani, Giuseppe, Pizzuti, Michele, La Verde, Giacinto, Avvisati, Giuseppe, Longinotti, Maurizio, Gallo, Eugenio, Dammacco, Franco, Russo, Domenico, Bacigalupo, Andrea, and Musolino, Caterina

Abstract

The phase 3 GIMEMA-MMY-3006 trial, which compared bortezomib, thalidomide, and dexamethasone (VTD) combination therapy with thalidomide and dexamethasone (TD) as induction therapy before and consolidation therapy after double autologous haematopoietic stem-cell transplantation (HSCT) for newly diagnosed multiple myeloma, showed the superiority of the triplet regimen over the doublet in terms of increased complete response rate and improved progression-free survival. We report the results from the final analysis of the study.

Published
2020
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23. In Transit: Edgar Degas and the Matter of Cotton, between New World and Old

Author

Foa, Michelle

Abstract

AbstractEdgar Degas’s stay in New Orleans in 1872–73, which marked his only visit to the New World, resulted in two remarkable paintings of a cotton office. Linking Southern cotton to the French textiles he frequently depicted and to his works’ paper supports demonstrates the centrality of the material to the artist’s corpus. More broadly, Degas’s cotton office paintings, as well as drawings and letters produced during his time abroad, reflect his meditation on the connections that bound the Old and New Worlds together and the transportation technology that facilitated the global circulation of people, goods, and communications.

Published
2020
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24. Decision of adjuvant chemotherapy in intermediate risk luminal breast cancer patients: A prospective multicenter trial assessing the clinical and psychological impact of EndoPredict® (EpClin) use (UCBG 2–14).

Author

Penault-Llorca, Frédérique, Kwiatkowski, Fabrice, Arnaud, Antoine, Levy, Christelle, Leheurteur, Marianne, Uwer, Lionel, Derbel, Olfa, Le Rol, Annick, Jacquin, Jean-Philippe, Jouannaud, Christelle, Quenel-Tueux, Nathalie, Girre, Véronique, Foa, Cyril, Guardiola, Emmanuel, Lortholary, Alain, Catala, Stéphanie, Guiu, Séverine, Valent, Alexander, Boinon, Diane, and Lemonnier, Jérome

Subjects
ADJUVANT treatment of cancer, CLINICAL trials, BREAST cancer, CANCER patients
Abstract

Genomic tests can identify ER-positive HER2-negative localized breast cancer patients who may not benefit from adjuvant chemotherapy. Such tests seem especially interesting in "intermediate" clinico-pathological risk categories. The psychological impact of the decision uncertainty in these women remains largely unexplored. We assessed the clinical and psychological impact of EndoPredict® (EpClin), a clinico-genomic test, in these patients. This multicenter, single arm prospective study (NCT02773004) enrolled patients for which adjuvant chemotherapy was uncertain, based on predefined criteria. The primary endpoint was the proportion of change between initial adjuvant decision and final administration of chemotherapy. Secondary endpoints included post-test (Day 17) and 1-year patient reported outcomes. One third of 200 evaluable patients had a high EpClin score (≥3.32867; 10 years cumulative risk of distance failure ≥10%). The overall change rate of chemotherapy decision was 72/200 (35.8%, 95% CI 29.2–42.4). Chemotherapy was withdrawn in 57 cases (28.4% [22.2–34.8]) and added in 15 (7.5% [3.8–11.2]. 6 changes (8%) were based on patients' decisions. Anxiety and distress levels increased at Day 17 when adding chemotherapy after the test result (p < 10−7 and 0.00022 respectively), while stable in other situations. At 1-year, all patients had returned to the baseline anxiety and distress levels (mean anxiety 51.5, +/− SD = 2.5 [max. 80], mean distress 3±1 [max. 10]). EndoPredict ® (EpClin) is clinically useful in deciding whether or not to administer adjuvant chemotherapy in patients with intermediate risk. A single-step decision is preferable since adding chemotherapy at a later stage increases anxiety and distress. • EndoPredict ® (EpClin) allowed a chemotherapy decision modification in 35% of the patients included in the Adendom trial. • Patient-physician concertation is important: 8% of treatment changes are based on patients' will. • A single-step decision including the test appears preferable to limit anxiety and distress. [ABSTRACT FROM AUTHOR]

Published
2020
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26. Patterns and Predictors of Change in Trauma-Focused Treatments for War-Related Posttraumatic Stress Disorder.

Author

Litz, Brett T., Berke, Danielle S., Kline, Nora K., Grimm, Kevin, Rusowicz-Orazem, Luke, Resick, Patricia A., Foa, Edna B., Wachen, Jennifer S., McLean, Carmen P., Dondanville, Katherine A., Borah, Adam M., Roache, John D., Young-McCaughan, Stacey, Yarvis, Jeffrey S., Mintz, Jim, and Peterson, Alan L.

Subjects
POST-traumatic stress disorder, COGNITIVE therapy, MILITARY personnel
Abstract

Objective: We evaluated patterns and predictors of change from three efficacy trials of trauma-focused cognitive–behavioral treatments (TF-CBT) among service members (N = 702; mean age = 32.88; 89.4% male; 79.8% non-Hispanic/Latino). Rates of clinically significant change were also compared with other trials. Method: The trials were conducted in the same setting with identical measures. The primary outcome was symptom severity scores on the PTSD Symptom Scale—Interview Version (PSS-I; Foa, Riggs, Dancu, & Rothbaum, 1993). Results: Symptom change was best explained by baseline scores and individual slopes. TF-CBT was not associated with better slope change relative to Present-Centered Therapy, a comparison arm in 2 trials. Lower baseline scores (β =.33, p <.01) and higher ratings of treatment credibility (β = −.22, p <.01) and expectancy for change (β = −.16, p <.01) were associated with greater symptom change. Older service members also responded less well to treatment (β =.09, p <.05). Based on the Jacobson and Truax (1991) metric for clinically significant change, 31% of trial participants either recovered or improved. Conclusions: Clinicians should individually tailor treatment for service members with high baseline symptoms, older patients, and those with low levels of credibility and expectancy for change. Three randomized trials demonstrated that trauma-focused cognitive–behavioral therapies for war-related posttraumatic stress disorder in active duty military personnel had rates of clinically significant change that were substantially smaller than in studies of civilians and not different from Present-Centered Therapy. This study highlights the importance of tailoring treatment for service members with high baseline symptoms, older patients, and those with lower levels of credibility and expectancy for change. [ABSTRACT FROM AUTHOR]

Published
2019
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29. La política ambiental internacional y el discurso del papa Francisco: ¿hacia una ecología del pueblo?

Author

Foa Torres, Jorge and Tuninetti, Luis

Abstract

Copyright of Letras Verdes is the property of FLACSO - Ecuador (Facultad Latinoamericana de Ciencias Sociales) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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32. Changes in Posttraumatic Stress Disorder (PTSD) and Depressive Symptoms Over the Course of Prolonged Exposure.

Author

Brown, Lily A., Jerud, Alissa, Asnaani, Anu, Petersen, Julie, Zang, Yinyin, and Foa, Edna B.

Subjects
TREATMENT of post-traumatic stress disorder, BEHAVIOR therapy, MENTAL depression
Abstract

Objective: Prior studies of prolonged exposure therapy (PE) suggested that reduction of posttraumatic stress disorder (PTSD) precedes reduction in depression, yet no research has collapsed data across multiple studies to examine whether the directionality of reduction remains consistent in larger and diagnostically diverse samples. Thus, the objective of this study is to conduct an evaluation of bidirectional associations between PTSD and depression in PE. Method: Participants (n = 216) from three randomized controlled trials of PE alone. PE + alcohol use disorder treatment, and PE + nicotine use disorder treatment completed weekly PTSD and depression severity measures. First, we analyzed the directional relationship between PTSD and depression over time in 2 single models to separately examine the effects of PTSD on depression and vice versa. Second, we analyzed a combined model to examine the simultaneous effects of reduction in PTSD on reduction in depression over and above the effects of reduction in depression on reduction in PTSD, and vice versa. Results: Two single models suggested that reductions in PTSD lead to reductions in depression and vice versa. The combined models suggested that both directions of change are important and reciprocal. The strength of predictive power from PTSD to depression, and vice versa, is approximately equal. Most significant prediction of PTSD from depression and vice versa occurred early in treatment. Conclusion: The relationship between reductions in PTSD and depression during PE is transactional. Regardless of whether PTSD or depression decreases first, reduction in the other symptom cluster is likely to follow. [ABSTRACT FROM AUTHOR]

Published
2018
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34. Hematopoietic stem cell transplantation for adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission: a position statement of the European Working Group for Adult Acute Lymphoblastic Leukemia (EWALL) and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)

Author

Giebel, Sebastian, Marks, David I., Boissel, Nicolas, Baron, Frederic, Chiaretti, Sabina, Ciceri, Fabio, Cornelissen, Jan J., Doubek, Michael, Esteve, Jordi, Fielding, Adele, Foa, Robin, Gorin, Norbert-Claude, Gökbuget, Nicola, Hallböök, Helene, Hoelzer, Dieter, Paravichnikova, Elena, Ribera, Josep-Maria, Savani, Bipin, Rijneveld, Anita W., Schmid, Christoph, Wartiovaara-Kautto, Ulla, Mohty, Mohamad, Nagler, Arnon, and Dombret, Hervé

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) in first complete remission is a standard of care for adult patients with Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL) and high risk of relapse. However, the stratification systems vary among study groups. Inadequate response at the level of minimal residual disease is the most commonly accepted factor indicating the need for alloHSCT. In this consensus paper on behalf of the European Working Group for Adult Acute Lymphoblastic Leukemia and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we summarize available evidence and reflect current clinical practice in major European study groups regarding both indications for HSCT and particular aspects of the procedure including the choice of donor, source of stem cells and conditioning. Finally, we propose recommendations for daily clinical practice as well as for planning of prospective trials.

Published
2019
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35. Predictors of EX/RP alone versus EX/RP with medication for adults with OCD: Does medication status moderate outcomes?

Author

Wheaton, Michael G., Rosenfield, Benjamin, Rosenfield, David, Marsh, Rachel, Foa, Edna B., and Simpson, H. Blair

Abstract

Exposure and response prevention (EX/RP) can be delivered as monotherapy or to augment serotonin reuptake inhibitors (SRIs). While both options are considered effective OCD treatments, responses are heterogenous. Substantial work has investigated EX/RP predictors to account for this variability, with mixed findings. Little research has studied whether EX/RP predictors may differ in medicated versus non-medicated samples (i.e., medication status as a moderator). We pooled data from two clinical trials conducted concurrently in the same specialty OCD clinic. One enrolled patients who were on stable SRI doses (EX/RP as SRI augmentation, n = 58) while the other enrolled non-medicated patients (EX/RP monotherapy, n = 38). Both trials used the same manualized EX/RP protocol and blinded independent evaluators. LASSO regression derived predictors and moderators of outcome. Improvement did not significantly differ between the EX/RP alone group and the SRI + EX/RP group. In both groups, higher baseline OCD severity and worse quality of life predicted poorer outcome. OCPD traits moderated results: Patients with more severe OCPD traits had better outcomes from EX/RP monotherapy than those receiving EX/RP with SRIs. Patient adherence to EX/RP homework mediated the associations between the baseline variables and outcome. The effect of OCPD traits on outcome warrants future study to improve care. • We studied predictors of EX/RP in medicated and non-medicated adults with OCD. • OCD improvement did not differ between the EX/RP alone and EX/RP + SRI groups. • Baseline OCD severity and quality of life predicted improvement in both groups. • OCPD traits related to outcomes only in the EX/RP alone group. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Floquet Engineering of a Diatomic Molecule through a Bichromatic Radiation Field

Author

Barriga, Edgar, Foa Torres, Luis E. F., and Cárdenas, Carlos

Abstract

We report on a theoretical study of a Cs2molecule illuminated by two lasers and show how this can result in novel quantum dynamics. We reveal that these interactions facilitate the bypass of the non-crossing rule, forming light-induced conical intersections and modifiable avoided crossings. Our findings show how laser field orientation and strength, along with initial phase differences, can control molecular-state transitions, especially on the micromotionscale. We also extensively discuss how the interaction of radiation with matter gives rise to the emergence of potential energy surfaces of hybrids of radiation and molecular states. This research advances a technique for manipulating photoassociation processes in Cs2molecules, offering potential new avenues in quantum control.

Published
2024
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39. Concurrent Varenicline and Prolonged Exposure for Patients With Nicotine Dependence and PTSD: A Randomized Controlled Trial.

Author

Foa, Edna B., Asnaani, Anu, Rosenfield, David, Zandberg, Laurie J., Gariti, Peter, and Imms, Patricia

Subjects
VARENICLINE, POST-traumatic stress disorder, NICOTINE addiction, PATIENTS
Abstract

Background: Prevalence of smoking among individuals with posttraumatic stress disorder (PTSD) is disproportionately high, and PTSD is associated with especially poor response to smoking cessation treatment. Objective: The current study examined whether integrating treatments for smoking cessation (varenicline plus smoking cessation counseling; VARCC) and PTSD (prolonged exposure therapy; PE) enhances smoking outcomes among smokers diagnosed with PTSD. Method: 142 adults with nicotine dependence (ND) and PTSD were randomized to a treatment program consisting of varenicline, smoking cessation counseling, and PE (VARCC + PE) or to VARCC only. Seven-day point prevalence abstinence (PPA) at posttreatment (3-months postquit day) and follow-up (6-months postquit day), verified by serum cotinine levels and exhaled carbon monoxide, was the primary smoking outcome. Psychological outcomes were PTSD and depression severity. Mixed effects models included baseline PTSD severity as a moderator of treatment condition effects. Results: Overall, VARCC + PE participants did not show greater PPA than VARCC participants. However, treatment effects were moderated by baseline PTSD severity. For participants with moderate and high PTSD severity, VARCC + PE led to significantly higher PPA than VARCC alone (ps<.05). No differences between treatment conditions emerged for participants with low baseline PTSD severity. Participants who received PE showed significantly greater reduction of PTSD and depression symptoms than those who did not receive PE. Conclusions: Integrating psychological treatment for PTSD and smoking cessation treatment enhances smoking cessation for participants with moderate or severe PTSD symptom severity, but does not enhance smoking cessation for participants with low baseline PTSD severity. [ABSTRACT FROM AUTHOR]

Published
2017
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40. Degas: A New Vision.

Author

Foa, Michelle

Subjects
IMPRESSIONIST exhibitions
Abstract

The article reviews the exhibition "Degas: A New Vision" at the Museum of Fine Arts in Houston, Texas and "Seurat's Circus Sideshow" at the Metropolitan Museum of Art in New York City.

Published
2017
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41. Protestants et catholiques n'ont-ils rien en commun ? Politisations ordinaires au temps des guerres civiles de Religion.

Author

FOA, Jérémie

Abstract

Copyright of Politix is the property of De Boeck Universite and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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42. Factor Structure and Measurement Invariance of the Obsessive-Compulsive Inventory - Child Version (OCI-CV) in General Population.

Author

Rodríguez-Jiménez, Tíscar, Godoy, Antonio, Piqueras, José A., Gavino, Aurora, Martínez-González, Agustín E., and Foa, Edna B.

Subjects
OBSESSIVE-compulsive disorder in children, OBSESSIVE-compulsive disorder in adolescence, PSYCHOLOGICAL tests, PSYCHODIAGNOSTICS, GENDER differences (Psychology)
Abstract

Evidence-based assessment is necessary as a first step for developing psychopathological studies and assessing the effectiveness of empirically validated treatments. There are several measures of obsessive-compulsive disorder (OCD) and/or symptomatology in children and adolescents, but all of them present some limitations. The Obsessive-Compulsive Inventory-Revised (OCI-R) by Foa and her colleagues has showed to be a good self-report measure to capture the dimensionality of OCD in adults and adolescents. The child version of the OCI (OCI-CV) was validated for clinical children and adolescents in 2010, showing excellent psychometric properties. The objective of this study was to examine the factor structure and invariance of the OCI-CV in the general population. Results showed a six-factor structure with one second-order factor, good consistency values, and invariance across region, age, and sex. The OCI-CV is an excellent inventory for assessing the dimensions of OCD symptomatology in general populations of children and adolescents. The invariance across sex and age warrants its utilization for research purposes. [ABSTRACT FROM AUTHOR]

Published
2017
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44. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry

Author

Sawhney, Jitendra PS., Kothiwale, Veerappa A., Bisne, Vikas, Durgaprasad, Rajashekhar, Jadhav, Praveen, Chopda, Manoj, Vanajakshamma, Velam, Meena, Ramdhan, Vijayaraghavan, Govindan, Chawla, Kamaldeep, Allu, Jagan, Pieper, Karen S., John Camm, A., Kakkar, Ajay K., Kakkar, Ajay K., Bassand, Jean-Pierre, John Camm, A., Fitzmaurice, David A., Goldhaber, Samuel Z., Goto, Shinya, Haas, Sylvia, Hacke, Werner, Mantovani, Lorenzo G., Misselwitz, Frank, Pieper, Karen S., Turpie, Alexander G.G., van Eickels, Martin, Verheugt, Freek W.A., John Camm, A., Bassand, Jean-Pierre, Goldhaber, Samuel Z., Haas, Sylvia, Kayani, Gloria, Mantovani, Lorenzo G., Fox, Keith A.A., Gersh, Bernard J., Luciardi, Hector Lucas, Gibbs, Harry, Brodmann, Marianne, Cools, Frank, Barretto, Antonio Carlos Pereira, Connolly, Stuart J., Spyropoulos, Alex, Eikelboom, John, Corbalan, Ramon, Hu, Dayi, Jansky, Petr, Nielsen, Jørn Dalsgaard, Ragy, Hany, Raatikainen, Pekka, Le Heuzey, Jean-Yves, Darius, Harald, Keltai, Matyas, Kakkar, Sanjay, Sawhney, Jitendra Pal Singh, Agnelli, Giancarlo, Ambrosio, Giuseppe, Koretsune, Yukihiro, Sánchez Díaz, Carlos Jerjes, Ten Cate, Hugo, Atar, Dan, Stepinska, Janina, Panchenko, Elizaveta, Lim, Toon Wei, Jacobson, Barry, Oh, Seil, Viñolas, Xavier, Rosenqvist, Marten, Steffel, Jan, Angchaisuksiri, Pantep, Oto, Ali, Parkhomenko, Alex, Al Mahmeed, Wael, Fitzmaurice, David, Goldhaber, Samuel Z., Hu, D.Y., Chen, K.N., Zhao, Y.S., Zhang, H.Q., Chen, J.Z., Cao, S.P., Wang, D.W., Yang, Y.J., Li, W.H., Yin, Y.H., Tao, G.Z., Yang, P., Chen, Y.M., He, S.H., Wang, Ying, Wang, Yong, Fu, G.S., Li, X., Wu, T.G., Cheng, X.S., Yan, X.W., Zhao, R.P., Chen, M.S., Xiong, L.G., Chen, P., Jiao, Y., Guo, Y., Xue, L., Wang, F.Z., Li, H., Yang, Z.M., Bai, C.L., Chen, J., Chen, J.Y., Chen, X., Feng, S., Fu, Q.H., Gao, X.J., Guo, W.N., He, R.H., He, X.A., Hu, X.S., Huang, X.F., Li, B., Li, J., Li, L., Li, Y.H., Liu, T.T., Liu, W.L., Liu, Y.Y., Lu, Z.C., Luo, X.L., Ma, T.Y., Peng, J.Q., Sheng, X., Shi, X.J., Sun, Y.H., Tian, G., Wang, K., Wang, L., Wu, R.N., Xie, Q., Xu, R.Y., Yang, J.S., Yang, L.L., Yang, Q., Yang, Y.J., Ye, Y., Yu, H.Y., Yu, J.H., Yu, T., Zhai, H., Zhan, Q., Zhang, G.S., Zhang, Q., Zhang, R., Zhang, Y., Zheng, W.Y., Zhou, B., Zhou, Z.H., Zhu, X.Y., Kakkar, S., Sawhney, J.P.S., Jadhav, P., Durgaprasad, R., Ravi Shankar, A.G., Rajput, R.K., Bhargava, K., Sarma, R., Srinivas, A., Roy, D., Nagamalesh, U.M., Chopda, M., Kishore, R., Kulkarni, G., Chandwani, P., Pothiwala, R.A., Padinhare Purayil, M., Shah, S., Chawla, K., Kothiwale, V.A., Raghuraman, B., Vijayaraghavan, G., Vijan, V.M., Bantwal, G., Bisne, V., Khan, A., Gupta, J.B., Kumar, S., Jain, D., Abraham, S., Adak, D., Barai, A., Begum, H., Bhattacharjee, P., Dargude, M., Davies, D., Deshpande, B., Dhakrao, P., Dhyani, V., Duhan, S., Earath, M., Ganatra, A., Giradkar, S., Jain, V., Karthikeyan, R., Kasala, L., Kaur, S., Krishnappa, S., Lawande, A., Lokesh, B., Madarkar, N., Meena, R., More, P., Naik, D., Prashanth, K., Rao, M., Rao, N.M., Sadhu, N., Shah, D., Sharma, M., Shiva, P., Singhal, S., Suresh, S., Vanajakshamma, V., Panse, S.G., Koretsune, Y., Kanamori, S., Yamamoto, K., Kumagai, K., Katsuda, Y., Sadamatsu, K., Toyota, F., Mizuno, Y., Misumi, I., Noguchi, H., Ando, S., Suetsugu, T., Minamoto, M., Oda, Hiroshi, Shiraishi, K., Adachi, S., Chiba, K., Norita, H., Tsuruta, M., Koyanagi, T., Yamamoto, K., Ando, H., Higashi, T., Okada, K., Azakami, S., Komaki, S., Kumeda, K., Murayama, T., Matsumura, J., Oba, Y., Sonoda, R., Goto, K., Minoda, K., Haraguchi, Y., Suefuji, H., Miyagi, H., Kato, H., Nakamura, Tadashi, Nakamura, Tsugihiro, Nandate, H., Zaitsu, R., Fujiura, Yoshihisa, Yoshimura, A., Numata, H., Ogawa, J., Tatematsu, H., Kamogawa, Y., Murakami, K., Wakasa, Y., Yamasawa, M., Maekawa, H., Abe, S., Kihara, H., Tsunoda, S., Saito, Katsumi, Saito, Kazuyuki, Fudo, T., Obunai, K., Tachibana, H., Oba, I., Kuwahata, T., Higa, S., Gushiken, M., Eto, T., Yoshida, H., Ikeda, D., Fujiura, Yoshitake, Ishizawa, M., Nakatsuka, M., Murata, K., Ogurusu, C., Shimoyama, M., Akutsu, M., Takamura, I., Hoshino, F., Yokota, N., Iwao, T., Tsuchida, K., Takeuchi, M., Hatori, Y., Kitami, Y., Nakamura, Yoichi, Oyama, R., Ageta, M., Oda, Hiroyuki, Go, Y., Mishima, K., Unoki, T., Morii, S., Shiga, Yuhei, Sumi, H., Nagatomo, T., Sanno, K., Fujisawa, K., Atsuchi, Y., Nagoshi, T., Seto, T., Tabuchi, T., Kameko, M., Nii, K., Oshiro, K., Takezawa, H., Nagano, S., Miyamoto, N., Iwaki, M., Nakamura, Yuichiro, Fujii, M., Okawa, M., Abe, Masahiko, Abe, Masatake, Abe, Mitsunori, Saito, T., Mito, T., Nagao, K., Minami, J., Mita, T., Sakuma, I., Taguchi, T., Marusaki, S., Doi, H., Tanaka, M., Fujito, T., Matsuta, M., Kusumoto, T., Kakinoki, S., Ashida, K., Yoshizawa, N., Agata, J., Arasaki, O., Manita, M., Ikemura, M., Fukuoka, S., Murakami, H., Matsukawa, S., Hata, Y., Taniguchi, T., Ko, T., Kubo, H., Imamaki, M., Akiyama, M., Inagaki, M., Odakura, H., Ueda, T., Katsube, Y., Nakata, A., Watanabe, H., Techigawara, M., Igarashi, M., Taga, K., Kimura, T., Tomimoto, S., Shibuya, M., Nakano, M., Ito, K., Seo, T., Hiramitsu, S., Hosokawa, H., Hoshiai, M., Hibino, M., Miyagawa, K., Horie, Hajime, Sugishita, N., Shiga, Yukio, Soma, A., Neya, K., Yoshida, Tetsuro, Yoshida, Tomoki, Mizuguchi, M., Ishiguro, M., Minagawa, T., Wada, M., Mukawa, H., Okuda, F., Nagasaka, S., Abe, Y., Adachi, Sen, Adachi, Susumu, Adachi, T., Akahane, K., Amano, T., Aoki, K., Aoyama, T., Arai, H., Arima, S., Arino, T., Asano, H., Asano, T., Azuma, J., Baba, T., Betsuyaku, T., Chibana, H., Date, H., Doiuchi, J., Emura, Y., Endo, M., Fujii, Y., Fujiki, R., Fujisawa, A., Fujisawa, Y., Fukuda, T., Fukui, T., Furukawa, N., Furukawa, T., Furumoto, W., Goto, T., Hamaoka, M., Hanazono, N., Hasegawa, K., Hatsuno, T., Hayashi, Y., Higuchi, K., Hirasawa, K., Hirayama, H., Hirose, M., Hirota, S., Honda, M., Horie, Hideki, Ido, T., Iiji, O., Ikeda, H., Ikeda, K., Ikeoka, K., Imaizumi, M., Inaba, H., Inoue, T., Iseki, F., Ishihara, A., Ishioka, N., Ito, N., Iwase, T., Kakuda, H., Kamata, J., Kanai, H., Kanda, H., Kaneko, M., Kano, H., Kasai, T., Kato, T., Kato, Y., Kawada, Y., Kawai, K., Kawakami, K., Kawakami, S., Kawamoto, T., Kawano, S., Kim, J., Kira, T., Kitazawa, H., Kitazumi, H., Kito, T., Kobayashi, T., Koeda, T., Kojima, J., Komatsu, H., Komatsu, I., Koshibu, Y., Kotani, T., Kozuka, T., Kumai, Y., Kumazaki, T., Maeda, I., Maeda, K., Maruyama, Y., Matsui, S., Matsushita, K., Matsuura, Y., Mineoi, K., Mitsuhashi, H., Miura, N., Miyaguchi, S., Miyajima, S., Miyamoto, H., Miyashita, A., Miyata, S., Mizuguchi, I., Mizuno, A., Mori, T., Moriai, O., Morishita, K., Murai, O., Nagai, Sho, Nagai, Shunichi, Nagata, E., Nagata, H., Nakagomi, A., Nakahara, S., Nakamura, M., Nakamura, R., Nakanishi, N., Nakayama, T., Nakazato, R., Nanke, T., Nariyama, J., Niijima, Y., Niinuma, H., Nishida, Y., Nishihata, Y., Nishino, K., Nishioka, H., Nishizawa, K., Niwa, I., Nomura, K., Nomura, S., Nozoe, M., Ogawa, T., Ohara, N., Okada, M., Okamoto, K., Okita, H., Okuyama, M., Ono, H., Ono, T., Onuki Pearce, Y., Oriso, S., Ota, A., Otaki, E., Saito, Y., Sakai, H., Sakamoto, N., Sakamoto, Y., Samejima, Y., Sasagawa, Y., Sasaguri, H., Sasaki, A., Sasaki, T., Sato, Kazuki, Sato, Kiyoharu, Sawano, M., Seki, S., Sekine, Y., Seta, Y., Sezaki, K., Shibata, N., Shiina, Y., Shimono, H., Shimoyama, Y., Shindo, T., Shinohara, H., Shinohe, R., Shinozuka, T., Shirai, T., Shiraiwa, T., Shozawa, Y., Suga, T., Sugimoto, C., Suzuki, Kazuo, Suzuki, Keita, Suzuki, Shu, Suzuki, Shunji, Suzuki, Susumu, Suzuki, Y., Tada, M., Taguchi, A., Takagi, T., Takagi, Y., Takahashi, K., Takahashi, S., Takai, H., Takanaka, C., Take, S., Takeda, H., Takei, K., Takenaka, K., Tana, T., Tanabe, G., Taya, K., Teragawa, H., Tohyo, S., Toru, S., Tsuchiya, Y., Tsuji, T., Tsuzaki, K., Uchiyama, H., Ueda, O., Ueda, T., Ueyama, Y., Wakaki, N., Wakiyama, T., Washizuka, T., Watanabe, M., Yamada, T., Yamagishi, T., Yamaguchi, H., Yamamoto, Kenichi, Yamamoto, Kentaro, Yamamoto, Kunihiko, Yamamoto, T., Yamaura, M., Yamazoe, M., Yasui, K., Yokoyama, Y., Yoshida, K., Lim, T.W., Ching, C.K., Foo, C.G., Chow, J.H., Chen, D.D., Jaufeerally, F.R., Lee, Y.M., Li, H., Lim, G., Lim, W.T., Thng, S., Yap, S.Y., Yeo, C., Oh, S., Pak, H.N., Kim, J.-B., Kim, J.H., Jang, S.-W., Kim, D.H., Kim, J., Ryu, D.R., Park, S.W., Kim, D.-K., Choi, D.J., Oh, Y.S., Cho, M.-C., Kim, S.-H., Jeon, H.-K., Shin, D.-G., Park, J.S., Park, H.K., Han, S.-J., Sung, J.H., Cho, J.-G., Nam, G.-B., On, Y.K., Lim, H.E., Kwak, J.J., Cha, T.-J., Hong, T.J., Park, S.H., Yoon, J.H., Kim, N.-H., Kim, K.-S., Jung, B.C., Hwang, G.-S., Kim, C.-J., Park, J.S., Kim, D.B., Ahn, J.J., An, H.J., Bae, H., Baek, A.L., Chi, W.J., Choi, E.A., Choi, E.H., Choi, H.K., Choi, H.S., Han, S., Heo, E.S., Her, K.O., Hwang, S.W., Jang, E.M., Jang, H.-S., Jang, S., Jeon, H.-G., Jeon, S.R., Jeon, Y.R., Jeong, H.K., Jung, I.-A., Kim, Hyeon Jeong, Kim, Hyun Ju, Kim, Ji Seon, Kim, 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Ferleyko, L., Fournier, D., Fox, B., Grenier, M.-C., Gulliver, W., Haveman, K., Hines, C., Hines, K., Jackson, A.M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., Ragy, H., Abd El-Aziz, A., Abou Seif, S.K., El Din, M.G., El Etriby, S., Elbahry, A., El-Etreby, A., Elkhadem, M., Katta, A., Khairy, T., Mowafy, A., Nawar, M., Ohanissian, A., Reda, A., Reda, M., Salem, H., Sami, N., Samir, S., Setiha, M., Sobhy, M., Soliman, A., Taha, N., Tawfik, M., Zaatout, E., Jacobson, B., Kettles, D., Bayat, J., Siebert, H., Horak, A., Kelfkens, Y., Garda, R., Pillay, T., Guerra, M., van Zyl, L., Theron, H., Murray, A., Louw, R., Greyling, D., Mntla, P., Ueckermann, V., Loghdey, R., Ismail, S., 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S., Beach, S., Sharma, N., Alfieri, A., Gutowski, T., Haque, I., Reddy, R., Ahmed, W., Delafontaine, P., Diercks, D., Theodoro, D., Remmel, K., Alberts, M., Ison, R., Noveck, H., Duffy, P., Pitta, S., Nishijima, D., Treasure, C., Asafu-Adjaye, N., Ball, K., Bartlett, M., Bentley, M., Bowers, S., Brown, A., Browne, A., Cameron-Watts, J., Canova, M., Cassidy, D., Cervellione, K., Congal, S., DePauw, J., Dickerson, A., Eley, M., Evans, L., Felpel, S., Ferdinand, K., Fielder, D., Gentry, P., Haideri, A., Hakimi, F., Harbour, T., Hartranft, E., Hawkins, B., Headlee, M., Henson, L., Herrick, C., Hicks, T., Jasinski, S., Johnson, K., Jones, A., Jones, L., Jones, P., Karl, S., Keeling, M., Kerr, J., Knowles, P., Langdon, J., Lay, M., Lee, J.A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.

Abstract

The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry.

Published
2018
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45. Silk flow-diverter stent for the treatment of complex intracranial aneurysms: A one-year follow-up multicenter study

Author

Foa Torres, G, Roca, F, Noguera, A, Godes, J, Petrocelli, S, Aznar, I, Ales, S, Muszynski, P, Maehara, R, Vicente, M, and Pumar, JM

Abstract

Background Flow-diverter stents have been successfully used in the treatment of complex aneurysms with limited therapeutic alternatives. We report our experience using the Silk flow diverter (SFD; Balt Extrusion, Montmorency, France) for the treatment of complex aneurysms in four Argentine centers.Methods We conducted a retrospective review of 246 consecutive patients who were treated with the SFD at four Argentine centers between January 2009 and January 2017. The patient and aneurysm characteristics, as well as the details of the procedure, were analyzed. The angiographic and clinical findings were recorded during and immediately after the procedure and at 12-month follow-up.Results Angiography follow-up at 12 months was possible in 235 patients (95.5%) with 282 aneurysms. A total of 265 aneurysms (93.9%) presented with complete occlusion of the aneurysmal sac (class 1) and 17 aneurysms (6.1%) presented with partial occlusion (class 2). The 12-month clinical follow-up showed 11 patients with major events (seven, scale 2; five, scale 3; and two, scale 4). The morbidity and mortality rates were 4.2% (11/289) and 2.1% (5/289), respectively.Conclusions The treatment of aneurysms with the SFD was associated with a low rate of complications and a high percentage of aneurysmal occlusion. These findings suggest that SFD is an effective and safe alternative in the endovascular treatment of complex aneurysms.

Published
2018
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46. The End of the Democratic Century.

Author

Mounk, Yascha and Foa, Roberto Stefan

Abstract

The article examines the decline of democracy worldwide and rising support for populist movements and anti-establishment sentiment. It looks at how changes in economic and military power around the world have contributed to these developments, citing forecasts that authoritarian countries such as China, Russia, and Saudi Arabia will surpass Western liberal democracies in terms of economic strength.

Published
2018

47. Efficacy and Safety of Obinutuzumab in Relapsed or Refractory Hairy Cell Leukemia (R/R HCL): An Italian Multicenter Phase-2 Academic Trial (HCL-PG04)

Author

Tiacci, Enrico, De Carolis, Luca, Capponi, Monia, Falcinelli, Flavio, Zaja, Francesco, Pulsoni, Alessandro, Simonetti, Edoardo, Montechiarello, Elisa, Romano, Alessandra, Olivieri, Jacopo, Mancini, Alessandro, D'Elia, Gianna Maria, Foa, Robin, Frezzato, Maurizio, and Falini, Brunangelo

Abstract

INTRODUCTION

Published
2023
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48. Real-Life Efficacy and Safety of Vemurafenib Plus Rituximab (V+R) in Relapsed or Refractory Hairy Cell Leukemia: A Multi-Center Retrospective Study (HCL-PG03R)

Author

Tiacci, Enrico, De Carolis, Luca, Capponi, Monia, Bernardelli, Andrea, Visentin, Andrea, D'Elia, Gianna Maria, Ferrero, Simone, Cimminiello, Michele, Romeo, Azzurra Anna, Pocali, Barbara, Falcinelli, Flavio, Sanna, Alessandro, Frustaci, Annamaria, Maschio, Nilla, Stelitano, Caterina, Olivieri, Jacopo, Visco, Carlo, Pulsoni, Alessandro, Foa, Robin, Trentin, Livio, and Falini, Brunangelo

Abstract

BACKGROUND

Published
2023
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49. CD49d Expression Is Included in a Revised 4-Factor Model Predicting Outcome in Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib: A Multi-Center Real-World Experience

Author

Bomben, Riccardo, Zucchetto, Antonella, Laureana, Roberta, Chiarenza, Annalisa, Olivieri, Jacopo, Tissino, Erika, Rossi, Francesca, Vit, Filippo, Bittolo, Tamara, Papotti, Robel, Pozzo, Federico, Gaglio, Annalisa, Degan, Massimo, Polesel, Jerry, Marasca, Roberto, Reda, Gianluigi, Visentin, Andrea, Moia, Riccardo, Innocenti, Idanna, Vitale, Candida, Murru, Roberta, Varettoni, Marzia, Tafuri, Agostino, Zaja, Francesco, Postorino, Massimiliano, Martino, Enrica Antonia, Condolucci, Adalgisa, Rossi, Davide, Cuneo, Antonio, Di Raimondo, Francesco, Sportoletti, Paolo, Del Giudice, Ilaria, Foa, Robin, Mauro, Francesca Romana, Coscia, Marta, Laurenti, Luca, Gaidano, Gianluca, Trentin, Livio, Del Principe, Maria Ilaria, Gentile, Massimo, and Gattei, Valter

Abstract

Introduction. Expression of the CD49d integrin chain has prognostic impact on ibrutinib (IB)-treated CLL patients (Tissino et al, J Exp Med, 2018; Tissino et al, Blood 2020). In addition, a 4-factor (4-f) score, based on TP53 aberration, β2-microglobulin (β2M), lactate dehydrogenase (LDH) and previous therapy lines was proposed to identify patients at a higher risk of treatment failure or death during IB therapy (Ahn et al, J Clin Oncol, 2020; Morabito et al, Am J Hematol, 2021). The clinical impact of TP53 disruption was recently refined by demonstrating that only the co-presence of TP53 deletion and mutations, and not the single aberrations, has prognostic value in the IB setting (Bomben et al, Leukemia 2022). The aim here is to integrate these observations in a comprehensive scoring for the management of IB-treated patients.

Published
2023
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50. A Propensity Score Weighting Analysis Emphasizes the Progress of the Gimema Approach in Adult Ph-Positive Acute Lymphoblastic Leukemia in the TKI Era

Author

Piciocchi, Alfonso, Chiaretti, Sabina, Cipriani, Marta, Messina, Monica, Elia, Loredana, Della Starza, Irene, Vitale, Antonella, Fazi, Paola, Vignetti, Marco, and Foa, Robin

Abstract

Introduction.In 2000, the GIMEMA cooperative study group launched the first frontline protocol with a tyrosine kinase inhibitor (TKI) alone plus steroids and without systemic chemotherapy for elderly (>60 years) Ph+ acute lymphoblastic leukemia (ALL) patients (LAL0201-B; Vignetti et al, Blood 2007). Thereafter, 4 academic clinical trials were conducted for adult patients (>18 years). In all studies, the induction was always based on a TKI alone plus steroids and CNS prophylaxis without systemic chemotherapy. In the GIMEMA LAL0904 trial, patients (18-60 years) received imatinib followed by chemotherapy in the post-induction phase (Chiaretti et al, Haematologica 2016). In the GIMEMA LAL1205 trial (no upper age limit), patients received dasatinib plus steroids, while the post-induction treatment was left to the investigator's choice (Foà et al, Blood 2011). In the GIMEMA LAL1509 total therapy protocol, patients (18-60 years) received dasatinib plus steroids followed by dasatinib alone in patients in complete molecular response (CMR) or chemotherapy and/or allogeneic transplant for those who did not reach a CMR (Chiaretti et al, Haematologica 2021). In the last LAL2116 trial, dasatinib plus glucocorticoids were administered in induction followed by at least two blinatumomab cycles as consolidation (Foà et al, N Engl J Med 2020). The rates of hematologic CR were comparable in the four trials, ranging from 96 to 100%.

Published
2023
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