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The inquiry into the impact of diverse transitions between cross-reality environments on user experience remains a compelling research endeavor. Existing work often offers fragmented perspectives on various techniques or confines itself to a singular segment of the reality-virtuality spectrum, be it virtual reality or augmented reality. This study embarks on bridging this knowledge gap by systematically assessing the effects of six prevalent transitions while users remain immersed in tasks spanning both virtual and physical domains. In particular, we investigate the effect of different transitions while the user is continuously engaged in a demanding task instead of purely focusing on a given transition. As a preliminary step, we evaluate these six transitions within the realm of pure virtual reality to establish a baseline. Our findings reveal a clear preference among participants for brief and efficient transitions in a task-driven experience, instead of transitions that prioritize interactivity and continuity. Subsequently, we extend our investigation into a cross-reality context, encompassing transitions between virtual and physical environments. Once again, our results underscore the prevailing preference for concise and effective transitions. Furthermore, our research offers intriguing insights about the potential mitigation of visual incoherence between virtual and augmented reality environments by utilizing different transitions.

Les patients les plus démunis ont tendance à moins adhérer à leurs traitements, à continuer à s’exposer à des facteurs de risque et finalement à avoir un moins bon pronostic. Il est donc nécessaire d’identifier précocement ces populations afin de leur fournir des soins adaptés et renforcés. L’objectif principal de cette étude est de construire et valider, en utilisant une méthodologie psychométrique, un outil de dépistage systématique de la fragilité sociale permettant d’identifier les patients les plus à risque, facile à utiliser par tous les professionnels de santé, afin de leur fournir des soins spécifiques et adaptés tout au long de leur parcours de soins.

Colloidal semiconductor nanocrystals have long been considered a promising source of time-correlated and entangled photons via the cascaded emission of multiexcitonic states. The spectroscopy of such cascaded emission, however, is hindered by efficient nonradiative Auger-Meitner decay, rendering multiexcitonic states nonemissive. Here we present room-temperature heralded spectroscopy of three-photon cascades from triexcitons in giant CsPbBr3nanocrystals. We show that this system exhibits second- and third-order correlation function values, g(2)(0) and g(3)(0,0), close to unity, identifying very weak binding of both biexcitons and triexcitons. Combining fluorescence lifetime analysis, photon statistics, and spectroscopy, we can readily identify emission from higher multiexcitonic states. We use this to verify emission from a single emitter despite high emission quantum yields of multiply excited states and comparable emission lifetimes of singly and multiply excited states. Finally, we present potential pathways toward control of the photon number statistics of multiexcitonic emission cascades.

Peripheral arterial ultrasound is an important technique to evaluate vascular disease. Protocols include grayscale, color Doppler and spectral Doppler. Arterial duplex is used to evaluate patients with claudication to characterize atherosclerotic disease. Stenoses have characteristic findings which can help profile lesions accurately. Other nonatherosclerotic obstructive processes are also evaluable by duplex Doppler. Traumatic injuries can also be studied in the stable patient. Attention to protocols helps ensure optimal results.

After clinical evaluation, especially clinical prediction rules, appropriately ordered venous duplex has become the standard test for evaluating and excluding deep vein thrombosis (DVT). Ultrasound is useful for lower- and upper-extremity veins. Protocols include grayscale, color Doppler, and spectral Doppler. Recommended lower-extremity protocols include central leg and calf veins. Duplex Doppler is widely used to evaluate patients with chronic venous disease, especially with suspected venous reflux. Mapping to identify adequate veins before surgery is another widely used indication for venous ultrasound. Ultrasound for thrombosis can be characterized as normal, acute DVT, superficial thrombosis, or chronic postthrombotic changes in most patients.

ABSTRACT:I study how increases in labor standards and enforcement affect workers and their families. Using a policy in Argentina that targeted domestic workers and their employers, I find a 31 percent increase in formality rates of domestic workers and an increase in monthly earnings of almost 4 percent, despite a reduction in hours of work. I also study whether the reform produced changes among other members of domestic workers' families. I find a substantial reduction in labor supply among children of domestic workers (especially women).

Wind erosion and variable weather challenge crop production in the northern Great Plains. Management that increases residue cover might mitigate wind erosion during the cash crop growing season. We evaluated horizontal sediment flux (modified Wilson and Cooke samplers) and cash crop yield across a single rotation of corn (Zea maysL.)–soybean (Glycine max(L.) Merr.)–spring wheat (Triticum aestivumL.) in paired fields with contrasting management. One field included cover crops and retained spring wheat straw (aspirational), while the other excluded both conservation practices over the 3‐year rotation (business‐as‐usual). Horizontal sediment flux rapidly decreased with days after cash crop planting (increasing crop canopy), regardless of management treatment. In 2 years (2020 corn and 2022 spring wheat), there was greater horizontal sediment flux, lower cash crop grain yield, and lower cash crop aboveground biomass in the aspirational versus business‐as‐usual field. In 2021 soybean, there was lower horizontal sediment flux, greater cash crop yield, and greater cash crop aboveground biomass in the aspirational versus business‐as‐usual field. Higher yield and lower horizontal sediment flux responses corresponded with the management treatment that produced the higher cash crop aboveground biomass. Additionally, our short‐term study indicated that in drought years, cover crops worsened the adverse effects of abnormally low precipitation on yield and biomass of 2020 corn but not 2021 soybean. Sediment mass flux and grain yield were measured in response to cover cropping and wheat straw management.Horizontal sediment flux rapidly decreased with canopy development, regardless of management treatment.During drought, cover crops decreased yield and biomass of corn but not soybean.Conservation practices treatment had lower horizontal sediment flux in 2021 soybean, but not in 2020 or 2022.

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Curative hepatitis C virus (HCV) therapy has increased transplantation from HCV-infected nucleic acid test-positive donors to HCV-uninfected recipients (D+/R-). We evaluated outcomes of early and late HCV treatment among D+/R- nonliver organ transplants. Patients received HCV regimens per local standard (n = 10 sites). Outcomes were compared between early and late treatments. Early treatment regimens (ETR) (n = 56) were initiated pretransplantation to day 7 posttransplant. Late treatment regimens (LTRs) (n = 102) began median 31 (range, 8-114) days posttransplant. There were 79 kidney, 50 lung, 23 heart, and 6 mixed transplants, similar between groups. HCV RNA was quantifiable in 98% of LTR versus 44.6% of ETR recipients (P< .001). Mean (range) days on treatment were 28 (7-93) ETR and 81 (51-111) LTR (P< .0001). There were no virological failures with ETR, but relapse (n = 3) and nonresponse (n = 2) in LTR (P= .16), including fibrosing cholestatic hepatitis postrelapse (n = 1). Sustained virological response was 100% (95% confidence interval, 93.4-100.0) in ETR (n = 54) and 94.9% (95% confidence interval, 88.5-98.3) in LTR (n = 98). Acute rejection occurred in 11 (19.6%) ETR and 25 (24.5%) LTR. In total, 11 HCV-unrelated deaths occurred: 8 ETR and 3 LTR. Organ transplantation from HCV-infected nucleic acid test-positive donors to HCV-uninfected recipients was safe. ETR led to fewer virological failures with shorter treatment duration, supporting recommendations to initiate treatment promptly posttransplant.

The brightness of an emitter is ultimately described by Fermi’s golden rule, with a radiative rate proportional to its oscillator strength times the local density of photonic states. As the oscillator strength is an intrinsic material property, the quest for ever brighter emission has relied on the local density of photonic states engineering, using dielectric or plasmonic resonators1,2. By contrast, a much less explored avenue is to boost the oscillator strength, and hence the emission rate, using a collective behaviour termed superradiance. Recently, it was proposed3that the latter can be realized using the giant oscillator-strength transitions of a weakly confined exciton in a quantum well when its coherent motion extends over many unit cells. Here we demonstrate single-photon superradiance in perovskite quantum dots with a sub-100 picosecond radiative decay time, almost as short as the reported exciton coherence time4. The characteristic dependence of radiative rates on the size, composition and temperature of the quantum dot suggests the formation of giant transition dipoles, as confirmed by effective-mass calculations. The results aid in the development of ultrabright, coherent quantum light sources and attest that quantum effects, for example, single-photon emission, persist in nanoparticles ten times larger than the exciton Bohr radius.

The success of colloidal semiconductor nanocrystals (NCs) in science and optoelectronics is inextricable from their surfaces. The functionalization of lead halide perovskite NCs1–5poses a formidable challenge because of their structural lability, unlike the well-established covalent ligand capping of conventional semiconductor NCs6,7. We posited that the vast and facile molecular engineering of phospholipids as zwitterionic surfactants can deliver highly customized surface chemistries for metal halide NCs. Molecular dynamics simulations implied that ligand–NC surface affinity is primarily governed by the structure of the zwitterionic head group, particularly by the geometric fitness of the anionic and cationic moieties into the surface lattice sites, as corroborated by the nuclear magnetic resonance and Fourier-transform infrared spectroscopy data. Lattice-matched primary-ammonium phospholipids enhance the structural and colloidal integrity of hybrid organic–inorganic lead halide perovskites (FAPbBr3and MAPbBr3(FA, formamidinium; MA, methylammonium)) and lead-free metal halide NCs. The molecular structure of the organic ligand tail governs the long-term colloidal stability and compatibility with solvents of diverse polarity, from hydrocarbons to acetone and alcohols. These NCs exhibit photoluminescence quantum yield of more than 96% in solution and solids and minimal photoluminescence intermittency at the single particle level with an average ON fraction as high as 94%, as well as bright and high-purity (about 95%) single-photon emission.

Der öffentlich-rechtliche Rundfunk (ÖRR) steht zu Recht in der Kritik. Mit dem technologischen Fortschritt und einem vielfältigen Medienangebot aus öffentlich-rechtlichen und privaten Sendern, dem Internet, diversen Streaming-Diensten und sozialen Medien haben die Rezipienten ihr Nutzungsverhalten stark verändert. Zudem schwindet die normative Rechtfertigung und gesellschaftliche Akzeptanz des ÖRR, der für kostenintensive Ausgaben sowie eine zu unausgewogene und zuweilen verzerrte Berichterstattung kritisiert wird. Auf Basis einer Analyse des 3. und 4. Medienänderungsstaatsvertrags entwickelt der Kronberger Kreis acht konkrete Reformschritte zur Stärkung der Governance des ÖRR. Eine Umsetzung dieser Reformempfehlungen würde dazu beitragen, einen möglichst hohen gesellschaftlichen Mehrwert durch den ÖRR und das zur Verfügung stehende Beitragsaufkommen zu generieren. Dadurch ließen sich nicht nur die Kosten des ÖRR senken, sondern auch seine Akzeptanz in der Bevölkerung stärken – und damit die Integrationsfunktion, die der ÖRR erfüllen soll.

ObjectiveTo assess the humoral response to the BNT162b2 mRNA vaccine among patients with spondyloarthritis (SpA) receiving secukinumab (SEC) compared to those receiving tumor necrosis factor inhibitors (TNFi) and immunocompetent controls.MethodsConsecutive patients with psoriatic arthritis or axial SpA receiving SEC (n = 37) or TNFi (monotherapy, n = 109; + methotrexate [MTX], n = 16), immunocompetent controls (n = 122), and patients with rheumatoid arthritis (RA) receiving TNFi therapy (controls, n = 50) were vaccinated with 2 or 3 doses of the BNT162b2 vaccine. We evaluated humoral response, adverse events, and disease activity, and monitored for breakthrough coronavirus disease 2019 (COVID-19) postvaccination.ResultsThe 2-dose vaccine regimen induced a comparable seropositive response in all study groups. S1/S2 antibody titers (in binding antibody units/mL; mean [SD]) were higher in the SEC group vs the TNFi + MTX–SpA and TNFi-RA groups (192.5 [68.4] vs 104.6 [46.9], P< 0.001, and 143.1 [81.9], P= 0.004). After 6 months, 96.3%, 96.6%, and 80.9% of the SEC, immunocompetent, and TNFi monotherapy-SpA groups (P= 0.10), respectively; 66.7% of the TNFi + MTX–SpA group (P= 0.03); and 63% of the TNFi-RA group (P= 0.004) remained seropositive. S1/S2 antibody titer decline was steeper in the TNFi groups than the SEC group. After the third dose, 100% of the SpA and immunocompetent and 88.9% of the TNFi-RA (P= 0.25) groups were seropositive. Rate of breakthrough COVID-19 infection was higher in the TNFi groups than in the SEC group (36-37.5% vs 10.8%). No significant between-group differences were observed for postvaccination disease activity and adverse events.ConclusionSEC did not interfere with the immunogenic response to BNT162b2 vaccine in patients with SpA; however, TNFi therapy was associated with lower S1/S2-antibody titers, faster decline, and higher rate of breakthrough infections.

Introduction: Migraine and endometriosis are chronic disabling pain conditions. There is evidence for a shared genetic background. Migraine phenotype and course in patients with the comorbidity are insufficient investigated. Both conditions can be treated with progestins. Methods: For this observational study we included women with migraine and endometriosis, visiting our clinic from 2015 to 2021. We collected available information from charts and complemented these data by a structured phone interview to collect more specific information on migraine and the course of both diseases. Results: From 344 patients fulfilling the inclusion criteria, 94 suffered from both, endometriosis and migraine. Migraine with aura was reported by 41% of the patients and was associated with earlier onset of migraine (age &lt; 17 years (OR 6.54) and with a history of medication overuse headache (OR 9.9, CI 1.6–59.4). Present monthly migraine frequency (1.5 ± 2.6) was significantly lower than five years before the interview (2.9 ± 4.64). There was a correlation between medication overuse headache and use of analgesics more than 3 days/months for dysmenorrhoea (p&lt; 0.03). ASRM endometriosis score was not associated with migraine characteristics. Conclusions: We conclude that the comorbidity of endometriosis is highly linked to migraine with aura. Migraine onset in these patients was earlier. Further studies are needed to explore, if the observed decrease in migraine frequency can be attributed to recent endometriosis surgery and to understand if early diagnosis and treatment of both conditions may contribute to improve the course of both conditions.

Pulsed field ablation (PFA) has emerged as a novel energy source for the ablation of atrial fibrillation (AF) using ultrarapid electrical pulses to induce cell death via electroporation.

Der vorliegende Beitrag setzt sich zum Ziel, zum Ersten einen Überblick über diejenigen Themen der Hefte der Zeitschrift Informationen Deutsch als Fremdsprache(Info DaF) aus dem ersten Jahrzehnt des einundzwanzigsten Jahrhunderts zu geben, die für die Praxis und für die Forschung im DaF-Bereich als besonders relevant und interessant erachtet werden. Zweitens werden die Fremdsprachenlehrendenausbildung und ihre notwendige inhaltliche Neugestaltung als wichtige Schwerpunkte in den Beiträgen von Info DaFund in den Fachdiskussionen außerhalb von Info DaFin diesem Jahrzehnt ins Visier genommen.

IMPORTANCE: Small waitlist candidates are significantly less likely than larger candidates to receive a liver transplant. OBJECTIVE: To investigate the magnitude of the size disparity and test potential policy solutions. DESIGN, SETTING, AND PARTICIPANTS: A decision analytical model was generated to match liver transplant donors to waitlist candidates based on predefined body surface area (BSA) ratio limits (donor BSA divided by recipient BSA). Participants included adult deceased liver transplant donors and waitlist candidates in the Organ Procurement and Transplantation Network database from June 18, 2013, to March 20, 2020. Data were analyzed from January 2021 to September 2021. EXPOSURES: Candidates were categorized into 6 groups according to BSA from smallest (group 1) to largest (group 6). Waitlist outcomes were examined. A match run was created for each donor under the current acuity circle liver allocation policy, and the proportion of candidates eligible for a liver based on BSA ratio was calculated. Novel allocation models were then tested. MAIN OUTCOMES AND MEASURES: Time on the waitlist, assigned Model for End-Stage Liver Disease (MELD) score, and proportion of patients undergoing a transplant were compared by BSA group. Modeling under the current allocation policies was used to determine baseline access to transplant by group. Simulation of novel allocation policies was performed to examine change in access. RESULTS: There were 41 341 donors (24 842 [60.1%] male and 16 499 [39.9%] female) and 84 201 waitlist candidates (53 724 [63.8%] male and 30 477 [36.2%] female) in the study. The median age of the donors was 42 years (IQR, 28-55) and waitlist candidates, 57 years (IQR, 50-63). Females were overrepresented in the 2 smallest BSA groups (7100 [84.0%] and 7922 [61.1%] in groups 1 and 2, respectively). For each increase in group number, waitlist time decreased (234 days [IQR, 48-700] for group 1 vs 179 days [IQR, 26-503] for group 6; P &lt; .001) and the proportion of the group undergoing transplant likewise improved (3890 [46%] in group 1 vs 4932 [57%] in group 6; P &lt; .001). The smallest 2 groups of candidates were disadvantaged under the current acuity circle allocation model, with 37% and 7.4% fewer livers allocated relative to their proportional representation on the waitlist. Allocation of the smallest 10% of donors (by BSA) to the smallest 15% of candidates overcame this disparity, as did performing split liver transplants. CONCLUSIONS AND RELEVANCE: In this study, liver waitlist candidates with the smallest BSAs had a disadvantage due to size. Prioritizing allocation of smaller liver donors to smaller candidates may help overcome this disparity.

The remarkable development and success of (international) commercial arbitration over the past sixty years have been accompanied by a surge of players and by an alteration in arbitrators’ ethos, translating into misbehaviours and inefficiency which have caused ethical concerns to move to the forefront of doctrinal debates. Based on the minimalistic approach of legislators, professional institutions and arbitration centres have attempted to address some of the issues raised by commercial arbitration users. The ensuing normative inflation has added up to the confusion, rather than assuaging users’ legitimate expectations for probity, competency and efficiency that seem no longer to be arbitration’s trademark. Restoring confidence in a dispute settlement mechanism, theoretically most suited to the needs of economic actors, requires the voluntary adoption and implementation of a coherent deontological corpus, in the interest of users, arbitrators and commercial arbitration itself.

Background:As First Nations Peoples are a priority focus of Canada’s commitment to eliminating hepatitis C virus (HCV) as a public health threat, understanding individuals’ progression from diagnosis to cure can guide prioritization of elimination efforts. We sought to characterize and identify gaps in the HCV care cascade for Status First Nations peoples in Ontario.Methods:In this retrospective cohort study, a partnership between the Ontario First Nations HIV/AIDS Education Circle and academic researchers, HCV testing records (1999–2018) for Status First Nations peoples in Ontario were linked to health administrative data. We defined the cascade of care as 6 stages, as follows: tested positive for HCV antibody, tested for HCV RNA, tested positive for HCV RNA, HCV genotyped, initiated treatment and achieved sustained viral response (SVR). We mapped the care cascade from 1999 to 2018, and estimated the number and proportion of people at each stage. We stratified analyses by sex, diagnosis date and location of residence. We used Cox regression to analyze the secondary outcomes, namely the associations between undergoing HCV RNA testing and initiating treatment, and demographic and clinical predictors.Results:By Dec. 31, 2018, 4962 people tested positive for HCV antibody. Of those testing positive, 4118 (83.0%) were tested for HCV RNA, with 2480 (60.2%) testing positive. Genotyping was completed in 2374 (95.7%) of those who tested positive for HCV RNA, with 1002 (42.2%) initiating treatment. Nearly 80% (n= 801, 79.9%) of treated people achieved SVR, with 34 (4.2%) experiencing reinfection or relapse. Undergoing testing for HCV RNA was more likely among people in older age categories (within 1 yr of antibody test; adjusted hazard ratio [HR] 1.30, 95% confidence interval [CI] 1.19–1.41, among people aged 41–60 yr; adjusted HR 1.47, 95% CI 1.18–1.81, among people aged > 60 yr), those living in rural areas (adjusted HR 1.20, 95% CI 1.10–1.30), those with an index date after Dec. 31, 2013 (era of treatment with direct-acting antiviral regimens) (adjusted HR 1.99, 95% CI 1.85–2.15) and those with a record of substance use or addictive disorders (> 1 yr after antibody test; adjusted HR 1.38, 95% CI 1.18–1.60). Treatment initiation was more likely among people in older age categories at index date (adjusted HR 1.32, 95% CI 1.15–1.50, among people aged 41–60 yr; adjusted HR 2.62, 95% CI 1.80–3.82, among people aged > 60 yr) and those with a later diagnosis year (adjusted HR 2.71, 95% CI 2.29–3.22).Interpretation:In comparison with HCV testing and diagnosis, a substantial gap in treatment initiation remains among Status First Nations populations in Ontario. Elimination efforts that prioritize linkage to care and integration with harm reduction and substance use services are needed to close gaps in HCV care among First Nations populations in Ontario.

BackgroundTo evaluate the association of age with long-term outcome after thrombectomy.MethodsIn a retrospective cohort study based on routine healthcare data from Germany between 2010 and 2018, we included 18 506 patients with acute ischaemic stroke treated with mechanical thrombectomy. Association between age and mortality, disability, and level of care at 1 year was assessed.ResultsThe median age was 76 years, 36.3% were aged ≥80 years and 55.8% were women. Patients aged ≥80 compared with those <80 years had a higher mortality (55.4% vs 28.5%; adjusted HR 1.13; 95% CI 1.05 to 1.31), more often had moderate/severe disability (35.5% vs 33.2%, adjusted HR 1.14; 95% CI 1.06 to 1.23) and less frequently had no/slight disability (17.4% vs 41.0%) at 1 year. Older age was associated with a higher likelihood of living in a nursing home (13.4% vs 9.2%, adjusted HR 1.09; 95% CI 0.97 to 1.22) and a lower likelihood of living at home (33.8% vs 62.8%) at 1 year. These associations were also robust when analysed in patients with no disability prior to stroke. Factors most strongly associated with worse 1-year outcomes in elderly patients were chronic limb-threatening ischaemia (67.9% vs 56.4%; HR 1.59, 95% CI 1.38 to 1.82), dementia at baseline (65.2% vs 47.3%; HR 1.29, 95% CI 1.17 to 1.44) and ventilation >48 hours (79.3% vs 52.2%; HR 2.91, 95% CI 2.66 to 3.18).ConclusionsIn this large ‘real-world’ cohort, outcomes after mechanical thrombectomy were strongly associated with age. Of patients aged ≥80 years more than half were dead and less than one-fifth were functionally independent at 1 year. Certain comorbidities and ventilation >48 hours were associated with even worse outcomes.

Purpose of Review: Teledermatology has emerged as a promising solution for remote dermatologic care, especially during COVID-19 pandemic. It improves access to care through information and communication technologies. This paper explores patient and clinician satisfaction in teledermatology. Recent Findings: Patient satisfaction encompasses various aspects, including future willingness, the quality of care, technical quality, and access to care. Clinician satisfaction is influenced by quality of care, implementation, technical aspects, clinician-patient rapport, and financial considerations. It is important to evaluate patient and clinician satisfaction in different teledermatology models, including store-and-forward, live interactive, and hybrid interactive approaches. Summary: By evaluating satisfaction within different teledermatology models and addressing the factors that impact satisfaction, teledermatology can ensure high-quality care and promote positive outcomes. With proper implementation and ongoing evaluation, teledermatology has the potential to become a widely accepted and valuable component of dermatologic care, offering enhanced access to specialized services.