95 results on '"Farmer, James P."'
Search Results
2. Free-Space Optical Communication Link With Liquid Crystal Beam-Steering
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Zhang, Guanxiong, Schreier, Andy, Wang, Xiuze, Matthews, William, Farmer, James, Faulkner, Grahame, Elston, Steve J., Morris, Stephen M., and O'Brien, Dominic
- Abstract
In this letter, we present a non-mechanical 2D beam-steering system suitable for optical wireless communication. Steering is achieved using polarization gratings combined with nematic liquid crystal cells operating as voltage-controlled polarization shifters. These steering elements are combined with a holographic diffuser matched to the discrete steering angles of the polarization grating, enabling continuous angular coverage. Beam-steering is also used at the receiver, allowing a large collection area receiver with a relatively narrow field of view to be used. The approach presented here could, in principle, be applied to a broad range of wavelengths (including visible light and near-infrared wavelengths). Furthermore, the technique does not inherently limit the transmission data rate. Besides, it improves the link margin and offers the potential for a bidirectional steered link using the same beam-steering elements. Details of the approach are set out in the letter, followed by experimental results from a 50 Mbit/s optical link operating over one meter. Future directions are then discussed.
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- 2023
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3. Substrate-Selective Adhesion of Metal Nanoparticles to Graphene Devices.
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Edwards, Patrick J., Stuart, Sean, Farmer, James T., Shi, Ran, Long, Run, Prezhdo, Oleg V., and Kresin, Vitaly V.
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- 2023
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4. Bond Activation by a Bimetallic GaI Complex: Avenue to Intermetallic Compounds.
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Helling, Christoph, Farmer, James C., Wölper, Christoph, Kretschmer, Robert, and Schulz, Stephan
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- 2023
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5. Complications and Revisions After Spine Surgery in Patients With Skeletal Dysplasia: Have We Improved?
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Shafi, Karim, Lovecchio, Francis, Sava, Maria, Steinhaus, Michael, Samuel, Andre, Carter, Erin, Lebl, Darren, Farmer, James, and Raggio, Cathleen
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Study Design: Retrospective case series.Objective: To report contemporary rates of complications and subsequent surgery after spinal surgery in patients with skeletal dysplasia.Methods: A case series of 25 consecutive patients who underwent spinal surgery between 2007 and 2017 were identified from a single institution’s skeletal dysplasia registry. Patient demographics, medical history, surgical indication, complications, and subsequent surgeries (revisions, extension to adjacent levels, or for pathology at a non-contiguous level) were collected. Charlson comorbidity indices were calculated as a composite measure of overall health.Results: Achondroplasia was the most common skeletal dysplasia (76%) followed by spondyloepiphyseal dysplasia (20%); 1 patient had diastrophic dysplasia (4%). Average patient age was 53.2 ± 14.7 years and most patients were in excellent cardiovascular health (88% Charlson Comorbidity Index 0-4). Mean follow up after the index procedure was 57.4 ± 39.2 months (range). Indications for surgery were mostly for neurologic symptoms. The most commonly performed surgery was a multilevel thoracolumbar decompression without fusion (57%). Complications included durotomy (36%), neurologic complication (12%), and infection requiring irrigation and debridement (8%). Nine patients (36%) underwent a subsequent surgery. Three patients (12%) underwent a procedure at a non-contiguous anatomic zone, 3 (12%) underwent a revision of the previous surgery, and another 3 (12%) required extension of their previous decompression or fusion.Conclusions: Surgical complication rates remain high after spine surgery in patients with skeletal dysplasia, likely attributable to inherent characteristics of the disease. Patients should be counseled on their risk for complication and subsequent surgery.
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- 2023
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6. Oculopharyngeal Muscular Dystrophy Ptosis, Mueller’s Muscle Involvement, and a Review of Management Over 34 Years
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Jordan, David R., Klapper, Stephen R., and Farmer, James
- Abstract
Oculopharyngeal muscular dystrophy is a hereditary myopathy with progressive dysphagia, proximal muscle weakness, and eyelid ptosis secondary to levator and often Mueller’s muscle involvement that may be challenging to correct depending on the severity of the patient’s disease.
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- 2022
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7. Socioeconomic threats are more salient to farmers than environmental threats.
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Waldman, Kurt B., Giroux, Stacey A., Farmer, James R., Heaberlin, Bradi M., Blekking, Jordan P., and Todd, Peter M.
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FARMERS' attitudes ,FARMERS ,DROUGHTS ,DAIRY farmers ,INTERNATIONAL trade disputes ,ECONOMIC shock - Abstract
It is a difficult time to be a farmer, particularly in the midwestern US, where a slow-moving farm crisis has been brewing. In recent years farmers have faced multiple socioeconomic threats such as a trade war with China, industry consolidation, and decreasing farmgate prices, as well as multiple environmental threats, including flooding and drought. We analyze farmers' assessments of these concurrent risks and their relationship to stress and farm exit, through a mail survey of 210 soy and dairy farmers in Indiana. On average, environmental threats are perceived as less of a threat to farmers than to immediate socioeconomic threats such as the trade war and, more importantly, long-run economic issues such as price decline and consolidation. We find evidence that farm exit is largely determined by farmer identity, perspectives on the trade war, and stress. The ongoing trade war with China is a key source of stress for soybean farmers and federal payments from the Market Facilitation Program are unlikely to stem farm exit. Addressing the farm exit problem and mitigating the current farm crisis necessitates greater attention to how policies, indirectly lead to farm exit through stress. • We analyze farmers' decisions to exit farming. • Farm exit is largely driven by perceived stress. • Environmental shocks pose less of a threat to farmers than economic shocks. • Market Facilitation Program payments are unlikely to stem farm exit. • The US-China trade is a key source of stress for farmers. [ABSTRACT FROM AUTHOR]
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- 2021
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8. The landowner role in beginning farmer/rancher land access: predictors of landowners' views of extrafamilial farm transfer to a BFR
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Valliant, Julia C.D., Dickinson, Stephanie, Zhang, Yijia, Golzarri-Arroyo, Lilian, and Farmer, James R.
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Purpose: Beginning farmers and ranchers (BFRs) are more likely to access land through an unrelated landowner than through family. Thus, farm and ranch owners who might transfer their land or businesses out of family are potential sources of land access for BFRs and are the most frequent participants in incentive programs to facilitate land transfer to BFRs. To assist in identifying landowners who might transfer out of family, the paper aims to explore similarities and differences between landowners according to their expectations for intra-familial versus extra-familial farm transfer. Design/methodology/approach: Pairwise and regression analysis of USA Midwestern and Plains landowners' responses to an online survey (n= 322). Findings: Landowners who might transfer out of family were likely to need the proceeds from a land sale to finance their retirement. Landowners' financial needs interacted with their widespread interest in transferring to a BFR such that 97% of owners who expected extra-familial transfer wanted to transfer to a BFR. There were also statistical patterns around the size of owners' landholdings in relation to their transfer plans. Research limitations/implications: This exploratory inquiry suggests patterns for future research to examine, especially around landowners' juxtaposition of their retirement income and their interest in transferring to a BFR and how to align these priorities and values. Originality/value: By exploring the characteristics of landowners who are the most likely to provide land access to BFRs, the authors begin to examine how to target these owners in program outreach. Patterns for further exploration point to landowners' financial needs in relation to their interest in helping a BFR to get started in agriculture.
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- 2022
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9. Farm Type and High Tunnel Management: Connections between Farm Characteristics and High Tunnel Outcomes in Indiana.
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Bruce, Analena B., Maynard, Elizabeth T., Valliant, Julia C. D., and Farmer, James R.
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TUNNELS ,COMMUNITY-supported agriculture ,FARMERS' markets ,ALTERNATIVE agriculture ,SUBWAYS ,CROP quality - Abstract
High tunnels are a low-cost technology that can strengthen local and regional food systems and have been shown to help farmers extend the growing season and increase the yield and shelf life, and improve the quality of their crops. This study addresses a need for a better understanding of farmers' experience with integrating high tunnels into their operations, to understand the human dimensions of high tunnel management. We present an analysis of survey and interview data to examine how farm characteristics affect the outcomes of growing specialty crops in high tunnels. Our findings show that farmers managing different types of farms have taken distinct approaches to integrating and managing high tunnels on their farms, with important implications for farm-level outcomes. We identify three types of farms commonly adopting high tunnels in Indiana: 1) alternative food and agriculture enterprises (AFAEs) are consumer-oriented, smallscale farms that sell their products directly to their customers in relationship-based market networks such as farmers' markets and community-supported agriculture; 2) mixed enterprise farmers have larger operations and sell into both conventional commodity markets and direct markets; and 3) side enterprise farmers operate small-scale enterprises and their primary household income comes from off-farm employment or another business. Farm type is associated with divergent levels of time and labor investment, resulting in higher capacity use of high tunnels and greater financial return for AFAE farmers who make high tunnels central to their business, compared with mixed and side enterprise farmers who invest less time and labor into their high tunnels. We explain how farm characteristics and approaches to adopting the infrastructure shape farmers' success and high-capacity use of high tunnels. [ABSTRACT FROM AUTHOR]
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- 2021
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10. Impact of the Novel Z‑Acceptor Ligand Bis{(ortho-diphenylphosphino)phenyl}zinc (ZnPhos) on the Formation and Reactivity of Low-Coordinate Ru(0) Centers.
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Miloserdov, Fedor M., Isaac, Connie J., Beck, Madeleine L., Burnage, Arron L., Farmer, James C. B., Macgregor, Stuart A., Mahon, Mary F., and Whittlesey, Michael K.
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- 2020
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11. Impact of the Novel Z-Acceptor Ligand Bis{(ortho-diphenylphosphino)phenyl}zinc (ZnPhos) on the Formation and Reactivity of Low-Coordinate Ru(0) Centers
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Miloserdov, Fedor M., Isaac, Connie J., Beck, Madeleine L., Burnage, Arron L., Farmer, James C. B., Macgregor, Stuart A., Mahon, Mary F., and Whittlesey, Michael K.
- Abstract
The preparation and reactivity with H2of two Ru complexes of the novel ZnPhos ligand (ZnPhos = Zn(o-C6H4PPh2)2) are described. Ru(ZnPhos)(CO)3(2) and Ru(ZnPhos)(IMe4)2(4; IMe4= 1,3,4,5-tetramethylimidazol-2-ylidene) are formed directly from the reaction of Ru(PPh3)(C6H4PPh2)2(ZnMe)2(1) or Ru(PPh3)3HCl/LiCH2TMS/ZnMe2with CO and IMe4, respectively. Structural and electronic structure analyses characterize both 2and 4as Ru(0) species in which Ru donates to the Z-type Zn center of the ZnPhos ligand; in 2, Ru adopts an octahedral coordination, while 4displays square-pyramidal coordination with Zn in the axial position. Under photolytic conditions, 2loses CO to give Ru(ZnPhos)(CO)2that then adds H2over the Ru–Zn bond to form Ru(ZnPhos)(CO)2(μ-H)2(3). In contrast, 4reacts directly with H2to set up an equilibrium with Ru(ZnPhos)(IMe4)2H2(5), the product of oxidative addition at the Ru center. DFT calculations rationalize these different outcomes in terms of the energies of the square-pyramidal Ru(ZnPhos)L2intermediates in which Zn sits in a basal site: for L = CO, this is readily accessed and allows H2to add across the Ru–Zn bond, but for L = IMe4, this species is kinetically inaccessible and reaction can only occur at the Ru center. This difference is related to the strong π-acceptor ability of CO compared to IMe4. Steric effects associated with the larger IMe4ligands are not significant. Species 4can be considered as a Ru(0)L4species that is stabilized by the Ru→Zn interaction. As such, it is a rare example of a stable Ru(0)L4species devoid of strong π-acceptor ligands.
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- 2020
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12. Wide Variability in Patient-Reported Outcomes Measures After Fusion for Lumbar Spinal Stenosis: A Systematic Review
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Winebrake, James P., Lovecchio, Francis, Steinhaus, Michael, Farmer, James, and Sama, Andrew
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Study Design: Systematic review.Objectives: The purpose of this study is to review outcomes reporting methodology in studies evaluating fusion for lumbar spinal stenosis.Methods: A systematic review of PubMed and Embase databases was conducted from January 2007 to June 2017 for English language studies with minimum of 2 years postoperative follow-up reporting outcomes after fusion for lumbar spinal stenosis. Two reviewers assessed each study; those meeting inclusion criteria were examined for pertinent data. Outcome measures were categorized into relevant domains: pain/symptomatology, function/disability, and surgical satisfaction. Return to work reporting was also recorded.Results: Of 123 studies meeting inclusion criteria, 76% included posterior-only fusion, 32% included posterior/transforaminal interbody fusion, and 5% included anterior/lateral interbody fusion (non-mutually exclusive). There was significant variation in patient-reported outcomes (PROs) used—studies reported 31 unique PROs assessing at least one domain: 22 evaluating pain, 23 evaluating function, and 3 evaluating surgical satisfaction. Most commonly utilized PROs were the Oswestry Disability Index (73% of studies), Visual Analog Scale (55%), and 36-Item Short Form Survey (32%). The remaining 28 measures were used in 14% of studies or fewer. PROs specific to symptoms of lumbar spinal stenosis, such as the Zurich Claudication Questionnaire, were only used rarely (7/123 studies). Only 14% of studies reported on time to return to work.Conclusions: The literature surrounding fusion in the setting of lumbar stenosis is characterized by substantial variability in outcomes reporting. Very few studies utilized measures specific to lumbar spinal stenosis. Efforts to standardize outcomes reporting would facilitate comparisons of surgical interventions.
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- 2020
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13. A curious case of arteritis: infectious, inflammatory, or both.
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Rullo, Jacob, Mehraban Far, Parsa, Farmer, James F., Clements-Baker, Marie, and ten Hove, Martin
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- 2019
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14. Immunohistochemical analysis of benign and malignant melanocytic lesions of the conjunctiva using double-staining.
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Soon, Alexander K., Brownstein, Seymour, Tang, Tina, Saleh, Solin, Jiang, Kailun, Levac, Joelle, Blanco, Paula, and Farmer, James
- Abstract
Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
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15. Periadventitial tissue examination in temporal artery biopsies for suspected giant cell arteritis: a case series and literature review.
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McDonald, Heather M., Farmer, James P., and Blanco, Paula L.
- Abstract
Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2019
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16. Papillomas in Goltz syndrome: case report, anaesthetic considerations, and review of the literature.
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Ruzicki, Jessica, Nair, Gopakumar Sudhakaran, Wang, Ami, Farmer, James, and Strube, Yi Ning J.
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- 2019
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17. Fostering farm transfers from farm owners to unrelated, new farmers: A qualitative assessment of farm link services.
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Valliant, Julia C.D., Ruhf, Kathryn Z., Gibson, Kevin D., Brooks, J.R., and Farmer, James R.
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FARM ownership ,FARMERS ,AGRICULTURAL taxes ,AGRICULTURAL economics ,SOCIAL media - Abstract
• Leaders of active and closed farm link services provide a critique of farm linking. • Monitoring medium-term outcomes is necessary for program success. Metrics provided. • However other services may be better strategies for programs with smaller budgets. • Larger institutions should create positions to assist with non-family farm transfers. • More states should replicate beginning farmer tax credit programs. The transition of farms and ranches to the next generation has generated considerable attention and concern. Over the past 30 years, public and private institutions across the U.S. have introduced policies and programs to help farms without identified family successors achieve successful transfers by connecting them with new farmers through "farm link" services. However, the effectiveness of these services is unclear and assessment is needed. This primarily qualitative study used interviews with program leaders and their responses to a questionnaire to assess the 30 active and closed farm link programs of the 12 states of the U.S. Midwest and Central Plains, resulting in a collection of best practice recommendations. Broadly, these programs target differing audiences and offer various services not limited to the function of linking farm/ranch owners with potential non-family successors. Most programs are located in NGO's (63%), with the others hosted by state departments of agriculture and land grant university extension systems. Program leaders agree that linking is needed to augment seekers' and owners' personal networks. They recommend that farm link services focus on medium-term outcomes, and provide a list of metrics. Program leaders also recommend other, complementary services to support and advance non-family transitions to new farmers, primarily: (1) state-level beginning farmer tax credits; (2) educating farm owners' advisors, such as lenders and tax preparers, about their clients' opportunities to transfer to an incoming farmer; (3) case management to facilitate transfers between unrelated parties; and (4) providing discussion spaces online and on social media to build farmer/rancher networks and relations between farm seekers and farm owners. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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18. Histiocytic sarcoma of the eyelid.
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Liu, Daisy Jiayi, Rullo, Jacob, Kratky, Vladimir, and Farmer, James
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Histiocytic Sarcoma is a rare malignant hematopoietic neoplasm that can present in extranodal sites including lymph nodes, skin, gastrointestinal tract, and the central nervous system. Only 10% of cases manifest as skin lesions and very few are reported in the head and neck. The authors report a case of histiocytic sarcoma of the eyelid in a 72-year-old male that was clinically diagnosed as a chalazion. Initial excision was not sent for routine histopathological assessment and the patient was subsequently lost to follow up. Recurrence occurred at the eyelid site and additional lesions were found on the forearms, abdomen, and right knee. Histopathological assessment of one of these other sites confirmed the diagnosis of histiocytic sarcoma. To our knowledge, this is the first reported case of disseminated histiocytic sarcoma that originally presented in the ocular adnexa (eyelid). And, as the initial lesion was not sent to Pathology and therefore potentially missed, this case highlights the importance of submitting tissue, including chalazia, for pathologic evaluation. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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19. Reply Re: “Oculopharyngeal Muscular Dystrophy Ptosis, Mueller’s Muscle Involvement, and a Review of Management Over 34 Years”
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Jordan, David R., Klapper, Stephen R., and Farmer, James
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- 2023
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20. Expanding the Contribution of Community Gardens to City Sustainability through Family Education Programs.
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Stavrianakis, Konstantinos and Farmer, James
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COMMUNITY gardens ,URBAN gardens ,EDUCATION conferences ,BEHAVIOR ,SUSTAINABILITY - Abstract
Limited outdoor residential spaces and the cost of high-quality, sustainably grown vegetables have led families to engage in community gardening. The educational and recreational opportunities provided by community gardening make the settings an appealing location for families to learn and share leisure time together. We used a mixed-methods approach to investigate the impacts that gardening education workshops in community gardens can have on family members and their environmental behaviors. We used a case study approach to analyze the data from observations, drawings and interviews in which participants reported a variety of positive impacts from the gardening workshops including socializing, health benefits and acquired knowledge. However, there was limited evidence of pro-environmental behavior change beyond gardening. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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21. Neurological and mental health outcomes among conventional and organic farmers in Indiana, USA.
- Author
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Khan, Khalid M, Baidya, Retushi, Aryal, Ashamsa, Farmer, James R, and Valliant, Julia
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Introduction. Every farming method, whether conventional or organic, has been associated with some sort of risky behaviors leading to health issues among farmers. Substantial evidence is not available in the literature to determine whether the magnitudes of health outcomes vary between conventional and organic farmers. The study investigated whether selfreported neurological and mental health symptoms differ between conventional and organic farmers living in Indiana, USA. Materials and method. A self-reported questionnaire survey collected information from 200 conventional and 157 organic farmers of Indiana on demographic characteristics, depression and neurological symptoms. Statistical analyses were conducted to observe the differences in self-reported symptoms by groups of farmers. Results. It was observed that the conventional farmers had significantly higher age-adjusted mean neurological symptom score (p<0.01) than the organic farmers. Regression models revealed positive and significant associations of conventional farming with total (β =1.34; p=0.02), sensory (β =0.83; p=0.001) and behavioural (β =0.09; p=0.03) symptoms after accounting for age, income, education and years in farming. Positive but non-significant associations were also observed in conventional farmers with cognitive and motor symptoms, and with all subscales of depression symptoms in the adjusted models. Conclusion. The findings obtained suggest the importance of a larger study to further explain the difference in mental and neurological health effects in these two categories of farmers. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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22. Characterization of serological markers of healed/healing arteritis and giant cell arteritis.
- Author
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Kansal, Vinay, Han, Sangsu, Farmer, James, and Albreiki, Danah
- Abstract
Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
23. Histopathological Study on the Proposed Pathogenesis of Intratarsal Keratinous Cysts
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Tang, Tina, Brownstein, Seymour, Chen, Henry, Jordan, David R., Iacob, Codrin E., Blanco, Paula, and Farmer, James
- Abstract
Utilizing histochemical and immunohistochemical examinations, this study demonstrates that intratarsal keratinous cysts are most likely derived from the meibomian ducts and can best be characterized with 3 immunohistochemical stains, cytokeratin 17, carcinoembryonic antigen, and epithelial membrane antigen.
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- 2019
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24. Farmers' Perspectives on Challenges and Opportunities Associated with Using High Tunnels for Specialty Crops.
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Bruce, Analena B., Maynard, Elizabeth T., and Farmer, James R.
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SPECIALTY crops ,TUNNELS ,CONSERVATION of natural resources ,CROP quality ,AGRICULTURAL diversification ,SOIL fertility - Abstract
High tunnels are an increasingly popular part of the infrastructure among small and diversified farms that market their products directly to consumers. In addition to extending the growing season, research has strongly indicated that high tunnels can increase yield, enhance shelf life, and improve the quality of crops grown. The objective of this study was to gain a better understanding, from the perspective of farmers, of the challenges and opportunities associated with adopting high tunnels for specialty crops in Indiana. We collected information through a case study that included questionnaires and in-depth interviews with 20 farmers. We found that the additional labor and time requirements of high tunnel production, the increased complexity of high tunnel production, soil fertility, and disease management, and limited winter markets posed the greatest challenges. The ability to differentiate their products based on higher quality and longer shelf life, the ability to obtain a premium price, the ability to have a source of income during the off-season, and the ability to produce complementary crops were the most important opportunities for using high tunnels. This research implied ways to expand opportunities and reduce barriers to maximizing the potential of high tunnels. Understanding the human dimensions of managing high tunnels is important for providing extension educators and Natural Resources Conservation Service field staff with better knowledge of the common difficulties and benefits of this technology so they are better able to advise farmers considering investing in a high tunnel. A focus on the human dimensions is also helpful for identifying research priorities to evaluate new approaches to decreasing problems and increasing benefits. Consequently, this study provided an in-depth understanding of farm-level challenges associated with high tunnel adoption to improve future research in diverse fields. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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25. Conserving nostalgia: exploring private land protection patterns
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Seaman, Alana, Farmer, James, Chancellor, H., and Sirima, Agnes
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The dramatic loss of open space in the USA over the last 50 years has led to increased conservation efforts by public, private, and non-profit entities. Amongst private landowners, conservation easements, or conditions written into a property’s title that permanently limit how it may be used, are a popular form of land protection. Private land protection is vital for both the conservation of America’s characteristic open spaces, and to ensure the future of many threatened and endangered plant and animal species. Yet little is known about the people who are placing conservation easements on their properties, the landscape features and land use practices currently being protected under conservation easements, or the ways in which these conservation patterns will continue into the future. Regardless, private land conservation efforts are shaping the American landscape; therefore, a thorough understanding of their characteristics is needed. Given that nostalgia, or an idealized and simplified notion of the past, underlies many of the motivations private landowners have for protecting their properties, this study suggests that there is a link between the type of nostalgia motivating private land protection and the types of land and land use practices being conserved. Further, the authors contend that this phenomenon is worthy of further investigation given its potential for environmental, social, and economic impact.
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- 2019
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26. A Multicenter Study Validates the WHO 2022 Classification for Conjunctival Melanocytic Intraepithelial Lesions With Clinical and Prognostic Relevance
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Mudhar, Hardeep Singh, Krishna, Yamini, Cross, Simon, Auw-Haedrich, Claudia, Barnhill, Raymond, Cherepanoff, Svetlana, Eagle, Ralph, Farmer, James, Folberg, Robert, Grossniklaus, Hans, Herwig-Carl, Martina C., Hyrcza, Martin, Lassalle, Sandra, Loeffler, Karin U., Moulin, Alexandre, Milman, Tatyana, Verdijk, Robert M., Heegaard, Steffen, and Coupland, Sarah E.
- Abstract
Several nomenclature and grading systems have been proposed for conjunctival melanocytic intraepithelial lesions (C-MIL). The fourth “WHO Classification of Eye Tumors” (WHO-EYE04) proposed a C-MIL classification, capturing the progression of noninvasive neoplastic melanocytes from low- to high-grade lesions, onto melanoma in situ (MIS), and then to invasive melanoma. This proposal was revised to the WHO-EYE05 C-MIL system, which simplified the high-grade C-MIL, whereby MIS was subsumed into high-grade C-MIL. Our aim was to validate the WHO-EYE05 C-MIL system using digitized images of C-MIL, stained with hematoxylin and eosin and immunohistochemistry. However, C-MIL cases were retrieved from 3 supraregional ocular pathology centers. Adequate conjunctival biopsies were stained with hematoxylin and eosin, Melan-A, SOX10, and PReferentially expressed Antigen in Melanoma. Digitized slides were uploaded on the SmartZoom platform and independently scored by 4 ocular pathologists to obtain a consensus score, before circulating to 14 expert eye pathologists for independent scoring. In total, 105 cases from 97 patients were evaluated. The initial consensus diagnoses using the WHO-EYE04 C-MIL system were as follows: 28 benign conjunctival melanoses, 13 low-grade C-MIL, 37 high-grade C-MIL, and 27 conjunctival MIS. Using this system resulted in 93% of the pathologists showing only fair-to-moderate agreement (kappa statistic) with the consensus score. The WHO-EYE05 C-MIL system (with high-grade C-MIL and MIS combined) improved consistency between pathologists, with the greatest level of agreement being seen with benign melanosis (74.5%) and high-grade C-MIL (85.4%). Lowest agreements remained between pathologists for low-grade C-MIL (38.7%). Regarding WHO-EYE05 C-MIL scoring and clinical outcomes, local recurrences of noninvasive lesions developed in 8% and 34% of the low- and high-grade cases. Invasive melanoma only occurred in 47% of the cases that were assessed as high-grade C-MIL. This extensive international collaborative study is the first to undertake a comprehensive review of the WHO-EYE05 C-MIL scoring system, which showed good interobserver agreement and reproducibility.
- Published
- 2024
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27. Cognitive biases in orbital mass lesions – Lessons learned.
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McDonald, Heather M., Farmer, James P., and Blanco, Paula L.
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Purpose A patient’s presentation and clinical diagnosis can at times be clouded by their past medical history. Clinicians’ anchoring bias towards initial information, such as a history of cancer, may lead them astray when creating a differential diagnosis for a patient who presents with new signs and symptoms of a mass lesion, assuming metastatic disease without seeking tissue confirmation. Methods The presentation, workup, diagnosis, and treatment of two patients who presented with orbital masses in the context of a primary prostate cancer are presented in this report. Results In both cases, prostate cancer metastasis to the orbit was top on the differential. Ultimately, histopathological examination of biopsies taken from the orbital masses revealed orbital lymphoma in both patients. Conclusion With mounting rates of patients who have survived a previous cancer, multiple primary cancers within one patient are becoming increasingly common. While prostate cancer metastasis to the orbit is a relatively rare event, orbital lymphoma is a more common diagnosis in orbital masses. Therefore, when patients present with orbital masses in the context of prostate cancer, the conclusion should not immediately be metastasis and a tissue diagnosis should be sought; especially given that the treatment of these entities is different. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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28. Family as a catalyst in farms' diversifying agricultural products: A mixed methods analysis of diversified and non-diversified farms in Indiana, Michigan and Ohio.
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Valliant, Julia C.D., Farmer, James R., Dickinson, Stephanie L., Bruce, Analena B., and Robinson, Jennifer Meta
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AGRICULTURAL diversification ,SIBLINGS ,FARM income ,AGRICULTURAL development ,AGRICULTURAL economics - Published
- 2017
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29. Silicone oil migration into periorbital space surrounding an extraocular muscle after sutureless 23-gauge vitrectomy in a child.
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Ruzicki, Jessica, Simpson, Sarah, Farmer, James, Kertes, Peter J., and Strube, Yi Ning J.
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EXOTROPIA ,RETINAL detachment ,VITRECTOMY ,SILICONES ,STRABISMUS surgery ,MUSCLES - Abstract
We report the case of an 11-year-old girl with a rare finding of silicone oil migration into the periorbital space surrounding an extraocular muscle, discovered during strabismus surgery for a sensory exotropia that had developed after retinal detachment repair by pars plana vitrectomy with intraocular silicone oil. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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30. Rebuilding local foods in Appalachia: Variables affecting distribution methods of West Virginia farms.
- Author
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Farmer, James Robert and Betz, Megan Elizabeth
- Subjects
LOCAL foods ,FARM produce ,PHYSICAL distribution of goods ,AGRICULTURE ,REGRESSION analysis - Abstract
Across the United States, farms are consolidating and fewer individuals earn their sole income from agriculture. At the same time, the number of very small farms—many of which engage in direct-to-consumer sales strategies—is on the rise. While much research has explored issues of size and scale for farms transitioning to organic certification, this study aims to elucidate the variables that predict whether farmers sell directly to consumers or through indirect methods such as food hubs, wholesalers, schools, and other institutions. Using a mailed survey to West Virginian farmers, this research attempted to better understand the similarities and differences between farms that produce specialty crops and animal products geared for local distribution via direct- and non-direct-to-consumer method of distribution. The goal of this research was to highlight variables that may affect the scaling of operations to include distribution methods beyond direct-to-consumer. To this end, a postal survey was sent to a list of West Virginia farmers focused on local distribution: specialty crop and animal producers were the focus of our list development. A total of 219 participants responded to the survey (29.2% response rate). After cleaning the dataset for the current analysis, 190 surveys were deemed useable. Regression analysis of survey data found that farmers selling through only direct-to-consumer strategies were more concerned about how their farming practices affected the environment, the production of high quality foods, and health risks associated with chemical usage; they were also more willing to try new methods than their non-direct counterparts. Additionally, higher levels of economic dependence on items such as costs of credit, loan availability, etc. was also a significant variable in predicting distribution type. Finally, our results indicate that farmers who are distributing food through non-direct means are demographically distinct from their local-only counterparts on a number of measures, including, most critically: educational attainment (−), acres farmed (+), and length of family ownership (+). Taken together, these variables point to access to land and capital as determinants of scale and marketing strategy. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
31. Student Outcomes of Eco-Restoration Service-Learning Experiences in Urban Woodlands
- Author
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Knackmuhs, Eric, Farmer, James, and Reynolds, Heather L.
- Abstract
Service learning with ecological restoration projects can positively affect participants’ attitudes, behaviors, and learning, but little is known about the longevity of these effects. Furthermore, urban green spaces are an understudied, yet increasingly important, context for eco-restoration service learning. This study examined the persistence of student outcomes of eco-restoration service-learning experiences in an urban woodland. Undergraduate courses from the Departments of Biology and Recreation, Park, and Tourism Studies at Indiana University partnered with the Bloomington Urban Woodlands Project (BUWP) to restore native woodland habitat and conduct public outreach. Phenomenological analysis of student interviews demonstrated that service-learning experiences improved learning outcomes and encouraged and reinforced pro-environmental attitudes up to 14 months later. Results also demonstrate the applicability of an environmental interpretation behavior change model to college-level instruction.
- Published
- 2017
- Full Text
- View/download PDF
32. Opportunities and barriers to certified organic grain production on rented farmland in the U.S. Midwest state of Indiana.
- Author
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Bruce, Analena B., Farmer, James R., Giroux, Stacey, Dickinson, Stephanie, Chen, Xiwei, Donnell, Michael O., and Benjamin, Tamara J.
- Subjects
LAND tenure ,ORGANIC certification ,SOCIAL norms ,ORGANIC farmers ,FARMERS' attitudes ,NATURE reserves - Abstract
Organic certification provides an opportunity for crop farmers to improve their viability and reduce the environmental impacts of commodity grain production, yet farmers have only transitioned to organic certification on less than five percent of US farmland. We focus on land tenure as a barrier to wider adoption of organic certification in the Midwest state of Indiana, where 50 % of farmland is rented. Addressing the lack of research on the relationship between tenant farmers and their non-operating landowners, we show how these relationships affect the adoption of conservation practices. Presenting findings from a survey and 30 in-depth interviews with conventional, transitioning, and organic farmers in Indiana, we show significant differences in land tenure arrangements for farmers certified and transitioning to organic compared to farmers only using conventional practices. We contextualize tenant-landlord relationship dynamics across the spectrum of practice adoption, illustrating how land tenure arrangements shape conservation management decision making. Our findings illustrate the barriers and opportunities to adoption of organic certification, given the variability in landowners' interest in organic certification. While conventional tenant farmers described long-term rental relationships characterized by a sense of trust, the high level of competition for access to rented farmland exerted pressure on them to conform to perceived norms about farming practices and avoid consideration of more risky and less socially acceptable or familiar conservation practices, for fear of losing their landlord's confidence and trust. • Land tenure constrains adoption of organic certification on rented land in Midwest. • Relationship between tenant farmers and non-operating landowners affects conservation. • Dynamics of land tenure shape conservation management decision making. • Competition for rented land constrains conservation adoption. • Norms about the appearance of crops constrains conservation adoption. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
33. A child with rapidly progressive necrotizing group a streptococcal Tenon's capsule infection one day after strabismus surgery.
- Author
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Yau, Gary L., Warder, Daniel, Farmer, James P., Urton, Todd, and Strube, Yi Ning J.
- Abstract
Periorbital infections after strabismus surgery are rare. We describe the first reported case of necrotizing group A streptococcal infection of the conjunctiva and Tenon's capsule complicating uneventful strabismus surgery in a 23-month-old boy, successfully managed with conservative intraoperative debridement and with targeted local and systemic antibiotics. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
34. Why agree to a conservation easement? Understanding the decision of conservation easement granting.
- Author
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Farmer, James R., Meretsky, Vicky, Knapp, Doug, Chancellor, Charles, and Fischer, Burney C.
- Subjects
LAND use ,CONSERVATION easements ,LANDOWNERS ,LABOR incentives ,LAND trusts - Abstract
In the United States, the amount of land protected by conservation easements dramatically increased between 2000 and 2010. As this mechanism for private land conservation continues to draw the attention of scientists, professionals, and policy makers, more information is needed on the landowner motivations and the variables affecting the placement of conservation easements. We surveyed landowners in the Midwest who had placed conservation easements on their properties in order to explore how nine various motive-values and exogenous variables, such as land characteristics and demographics, affected the decision to place conservation easements. The results suggested that those receiving monetary benefits from their land indicated were less likely to adopt a conservation easement without the accompanying financial incentives and did not share the same level of environmental motives as those receiving predominantly non-monetary benefits. In addition, absentee landowners appear less affected by financial incentives than those with permanent residences on or adjacent to the protected properties. Overall, our findings demonstrate the variation in motive-values of those receiving monetary vs. non-monetary benefits from their land, as well as highlight the differences in absentee vs. permanent landowners. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
35. Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2
- Author
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Casella, Bianca Maria, Farmer, James P., Nesheva, Desislava N., Williams, Huw E. L., Charlton, Steven J., Holliday, Nicholas D., Laughton, Charles A., and Mistry, Shailesh N.
- Abstract
The inhibition of CXC chemokine receptor 2 (CXCR2), a key inflammatory mediator, is a potential strategy in the treatment of several pulmonary diseases and cancers. The complexity of endogenous chemokine interaction with the orthosteric binding site has led to the development of CXCR2 negative allosteric modulators (NAMs) targeting an intracellular pocket near the G protein binding site. Our understanding of NAM binding and mode of action has been limited by the availability of suitable tracer ligands for competition studies, allowing direct ligand binding measurements. Here, we report the rational design, synthesis, and pharmacological evaluation of a series of fluorescent NAMs, based on navarixin (2), which display high affinity and preferential binding for CXCR2 over CXCR1. We demonstrate their application in fluorescence imaging and NanoBRET binding assays, in whole cells or membranes, capable of kinetic and equilibrium analysis of NAM binding, providing a platform to screen for alternative chemophores targeting these receptors.
- Published
- 2023
- Full Text
- View/download PDF
36. Conjunctival malignant melanoma: A rare variant and review of important diagnostic and therapeutic considerations.
- Author
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Albreiki, Danah H., Gilberg, Steven M., and Farmer, James P.
- Abstract
Abstract: Malignant melanoma of the conjunctiva is a relatively infrequent neoplasm that can be associated with significant morbidity and cause diagnostic difficulty to both the ophthalmologist and pathologist. We herein describe the first reported case in North American and European databases of a rare variant-signet ring cell melanoma – arising in the background of primary acquired melanosis (PAM) and use this case as a review of important diagnostic and therapeutic considerations when faced with this condition. [Copyright &y& Elsevier]
- Published
- 2012
- Full Text
- View/download PDF
37. Space to Romp and Roam and How It May Promote Land Conservation.
- Author
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Farmer, James R., Chancellor, Charles, and Fischer, Burnell C.
- Abstract
This study examined the significant life experiences (SLE) of individuals who had placed conservation easements on private property. Specifically, this study explored how early life experiences may impact ones conservation ethic to effect decisions on land protection. The researchers utilized a sequential embedded mixed methods research design, relying on both qualitative and quantitative data in order to develop an understanding of the phenomenon. All participants for ihi~ study were individuals who had placed a conservation easement on her or his property in lndi~nia. The mixed method analysis indicates that individual and infom~al experiences in and about the outdoors had the greatest perceived impact and were significantly dift~rent than more formalized experiences among the study's participants. The discussion focuses on the impact of informal experiences in the outdoors and the impact on the sell-perceived development of conservation ethics as significant life experiences pertaining to conservation behavior and the placing of conservation easements. Implications of this exploratory study arc discussed as they pertain to practitioners and scholars alike. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
38. Motivations for Using Conservation Easements as a Land Protection Mechanism: a Mixed Methods Analysis.
- Author
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Farmer, James R., Chancellor, Charles, and Fischer, Burnell C.
- Abstract
This study examined landowners' motivations for placing conservation easements on personal property. A mixed method sequential embedded research framework was utilized to elucidate the motivations of greatest consequence for landowners adopting conservation easements throughout Indiana. Specifically, the researchers sampled owners of agricultural and forestland who have adopted conservation easements. The qualitative results indicate that the motivation to limit development stems from witnessing the development of land, environmental ethics and values, personal history associated with the place, and the need for farmland for the public good. The quantitative results suggest that environmental values were the primary motivation for conservation easement adoption, with uniqueness of place being ranked second. Discussions of the study's results are presented with implications for the land conservation and conservation behavior fields. Finally, future directions for research within the phenomena of conservation easement usage are suggested. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
39. Characterization of lymphoproliferative lesions of the conjunctiva: immunohistochemical and molecular genetic studies.
- Author
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Farmer, James P., Lamba, Manisha, Merkur, Andrew B., Lamba, Wiplove R., Hodge, William G., Jordan, David R., Sengar, Dharmendra P.S., and Burns, Bruce F.
- Subjects
LYMPHOPROLIFERATIVE disorders ,IMMUNOHISTOCHEMISTRY ,MOLECULAR genetics ,RETROSPECTIVE studies ,BIOPSY ,IMMUNOPHENOTYPING ,DIAGNOSTIC use of polymerase chain reaction - Abstract
Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2006
- Full Text
- View/download PDF
40. Initial biomechanical properties of staple-anchor Achilles tendon allograft and interference screw bone-patellar tendon-bone autograft fixation for anterior cruciate ligament reconstruction in a cadaveric model.
- Author
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Farmer, James M., Lee, Cassandra A., Curl, Walton W., Martin, David F., Kortesis, Bill, and Poehling, Gary G.
- Subjects
TRANSPLANTATION of organs, tissues, etc. ,JOINTS (Anatomy) ,MUSCULOSKELETAL system ,ARTHROSCOPY - Abstract
Purpose: Anterior cruciate ligament (ACL) reconstruction is a common procedure that has a fairly high success rate. Despite such success, controversy exists with regard to fixation and graft type. The purpose of this study was to quantify the maximum load to failure for staple-anchor freeze-dried Achilles tendon allograft fixation compared with interference screw bone-pattelar tendon-bone autograft fixation at the time of insertion for ACL reconstruction.Methods: Eleven pairs of cadaveric knees were prepared for ACL reconstruction by disarticulation before graft insertion. The tibia and femur were mounted separately onto an MTS machine and were loaded to failure in line with the tunnels. Femoral fixation for the allograft was provided by a staple anchor; tibial fixation was provided by a suture anchor. Titanium interference screws on the femoral and tibial sides provided autograft fixation. A paired t test was performed to compare mechanical testing results in the 2 groups.Results: Mean maximum load to failure for the allograft was 58.7 N (range, 32.3 to 92.6 N) and 119.6 N (range, 82 to 165.9 N) for the femur and the tibia, respectively, compared with 228.2 N (range, 74.2 to 352 N) and 232.9 N (range, 65.1 to 553.1 N) for the autografts. This difference was statistically significant (P < .001) for femoral fixation, but it was not statistically significant for tibial fixation (P = .186).Conclusions: Soft tissue Achilles tendon allograft with staple fixation is a significantly weaker fixation construct when compared with autograft bone-patellar tendon-bone with interference screw fixation.Clinical Relevance: This study shows significantly weaker fixation in the staple-alograft construct and yet this construct has had at least equivalent results over a 5-year time frame, indicating that rigid femoral fixation may not be a critical factor in long-term results. [ABSTRACT FROM AUTHOR]- Published
- 2006
- Full Text
- View/download PDF
41. Orbital giant cell angiofibroma: immunohistochemistry and differential diagnosis.
- Author
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Farmer, James P., Lamba, Manisha, McDonald, Hector, and Commons, A. Susan
- Subjects
GIANT cell tumors ,DIFFERENTIAL diagnosis ,IMMUNOHISTOCHEMISTRY ,OCULAR radiography ,EYELID tumors ,HEMOSTASIS ,CD antigens ,DISEASES in women ,DIAGNOSIS - Abstract
Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2006
- Full Text
- View/download PDF
42. Lymphoproliferative lesions of the lacrimal gland: clinicopathological, immunohistochemical and molecular genetic analysis.
- Author
-
Farmer, James P., Lamba, Manisha, Lamba, Wiplove R., Jordan, David R., Gilberg, Steven, Sengar, Dharmendra P.S., Bence-Bruckler, Isabelle, and Burns, Bruce F.
- Subjects
LYMPHOPROLIFERATIVE disorders ,LACRIMAL apparatus ,PATHOLOGY ,IMMUNOHISTOCHEMISTRY ,MOLECULAR genetics ,LYMPHOCYTES ,HISTOPATHOLOGY ,LYMPHOMAS ,IMMUNOGLOBULIN genes - Abstract
Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2005
- Full Text
- View/download PDF
43. Agrileisure
- Author
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Farmer, James R., Chancellor, Charles, Robinson, Jennifer M., West, Stephanie, and Weddell, Melissa
- Abstract
AbstractParticipation in local food systems has recently emerged as an important and overlooked leisure behavior that is critical to community recreation agencies, sustainable development, and overall public health. This study collected motivational, participation, and demographic data from 712 individuals who shop at farmers' markets, subscribe to community supported agriculture (CSA) programs, or do not participate in either. The results indicate that environmental and nutritional motives were the top two factors affecting farmers' market and CSA participants' engagement, while also highlighting a significant association between the CSA and farmers' market participants and privilege variables. These findings suggest that even as farmers' markets and CSAs are promoted as a means to reduce food insecurity and promote agrileisure opportunities, barriers exist that exclude many from engagement.
- Published
- 2014
- Full Text
- View/download PDF
44. Usefulness of a Red Chromagen in the Diagnosis of Melanocytic Lesions of the Conjunctiva
- Author
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Jiang, Kailun, Brownstein, Seymour, Lam, Kay, Burns, Bruce, and Farmer, James
- Abstract
IMPORTANCE Immunohistochemical analyses may assist in the diagnosis of precancerous and cancerous conjunctival lesions. OBJECTIVE To use Vector Red (VR) to identify an immunologic marker that is sensitive for all melanocytes and another that is sensitive and specific for activated and/or atypical conjunctival melanocytic lesions (MLs). DESIGN, SETTING, AND PARTICIPANTS Eight specimens each of control lesions (normal conjunctiva and normal uvea as well as choroidal melanoma) and 8 from the diagnostic categories (conjunctival nevus, primary acquired melanosis with mild or no atypia, primary acquired melanosis with moderate to severe atypia, and conjunctival melanoma) that provided sufficient quantity and quality of tissue were available for processing. The specimens were obtained from the Ophthalmic Pathology Laboratory, The Ottawa Hospital, from 2005 to 2013. The specimens were immunolabeled with human melanoma black 45 (HMB45), melanoma antigen recognized by T cells 1 (Melan-A), S100, and Ki67 using VR and a double panmelanoma cocktail (dPANMEL) using 3,3′-diaminobenzidine (DAB) and VR. The HMB45-immunolabeled specimens were additionally developed with DAB, with and without overnight bleaching with hydrogen peroxide, 4%. Data were collected by 2 pathologists who were masked to sample grouping. MAIN OUTCOMES AND MEASURES Differentiation between benign and malignant MLs based on immunomarker profile. RESULTS Immunoreactivity was best visualized in specimens with VR. Melan-A labeled all melanocytes (100% sensitivity; panmelanocyte marker) without discriminating between benign and malignant lesions (0% specificity). Atypical melanocytes were most specifically labeled with HMB45 (96% specificity, 97% sensitivity; atypia marker). In primary acquired melanosis specimens, we found that the percentage of HMB45 (P < .001), S100 (P < .001), and Ki67 (P ≤ .02) positivity increased significantly with worsening atypia. CONCLUSIONS AND RELEVANCE We recommend VR, which rarely requires specimen bleaching, as the standard substrate for immunohistochemical analysis of conjunctival MLs. We found Melan-A and HMB45 to best characterize MLs. In conjunctival MLs, the use of VR with Melan-A and HMB45 provides substantial sensitivity for all melanocytes and for atypical melanocytes, respectively, and reduces specimen-processing time for laboratories performing immunohistochemistry on MLs.
- Published
- 2014
- Full Text
- View/download PDF
45. DEAN HESS AND THE BATTLE HYMN MUSTANGS.
- Author
-
FARMER, JAMES H.
- Abstract
The article presents the author's insights on Colonel Dean Hess and the film "Battle Hymn" Mustang. The author says that Hess offer insights into story that had become a 1956 best-selling autobiography and served as the technical advisor of the film. He adds that he received a call from National Aviation Hall of Fame executive director his interest in co-presenting a screening of "Battle Hymn" at the Reel Stuff festival of aviation films in Dayton, Ohio.
- Published
- 2013
46. Climate change impacts and urban green space adaptation efforts: Evidence from U.S. municipal parks and recreation departments.
- Author
-
Cheng, Yuan (Daniel), Farmer, James R., Dickinson, Stephanie L., Robeson, Scott M., Fischer, Burnell C., and Reynolds, Heather L.
- Abstract
Municipal parks and recreation departments (PRDs) have a crucial responsibility for stewarding urban and peri-urban ecology given they manage the majority of urban green spaces. However, the extent of climate adaptation planning and management activities by such agencies at the national level is unknown. This study aimed to fill this gap by conducting a national survey of the directors of PRDs (n = 413) to understand the progress and drivers of climate change adaptation efforts for urban green spaces. Overall, we found that while measured impacts of climate change were positively correlated with PRDs' climate-change adaptation plans and actions, most PRDs perceived few impacts of climate change on urban green spaces. We also found that levels of adaptation varied across ecoregions, with direct experiences with climate change impacts being a primary contributor to action. These findings indicate that U.S. municipal PRDs are unprepared for the changing climate and are unlikely to initiate urban green space adaptation planning and action until substantial climate change impacts are experienced firsthand. • Municipal parks departments tend to adapt to immediate problems related to climate change. • Experiences with climate-change-related problems motivate municipal parks departments to take adaptation steps. • Perceived impacts of extreme drought tend to motivate more actions among municipal parks departments. • Sharing data and adaptation plans within similar eco-regions may stimulate quicker implementation of adaptation efforts. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
47. Discography-Induced Acute Lumbar Disc Herniation
- Author
-
Poynton, Ashley R, Hinman, Adrian, Lutz, Gregory, and Farmer, James C
- Abstract
The reported complication rate of provocative lumbar discography is low, ranging from 0-2.5%. We report five cases of acute lumbar disc herniation precipitated by discography, a previously unreported complication. The cases reported comprise of four men and one woman with ages ranging from 23-45 years. All developed an acute exacerbation of radicular leg pain following multilevel provocative lumbar discography. One patient developed an acute foot drop. Comparison of lumbar MRI scans before and after discography demonstrated either a new herniated disc fragment or an increase in size of a preexisting herniation in all cases. On review of each discogram study and pre-discogram MRI an annular tear or small disc herniation was noted in all cases. In each case the patients' symptoms failed to resolve necessitating surgical intervention in all cases. In conclusion, annular deficiency is an obvious predisposing factor to discogram related disc herniation. New onset or a persistent exacerbation of radicular symptoms following provocative discography merits further investigation.
- Published
- 2005
- Full Text
- View/download PDF
48. Pharmacokinetics and Safety of an Anti-Vascular Endothelial Growth Factor Aptamer (NX1838) Following Injection into the Vitreous Humor of Rhesus Monkeys
- Author
-
Drolet, Daniel, Nelson, Joyce, Tucker, Christopher, Zack, Philip, Nixon, Kerry, Bolin, Richard, Judkins, Mark, Farmer, James, Wolf, Julie, Gill, Stanley, and Bendele, Raymond
- Abstract
Purpose. The objective of this study was to determine the pharmacokinetics and safety for NX1838 following injection into the vitreous humor of rhesus monkeys. Methods. Plasma and vitreous humor pharmacokinetics were determined following a single bilateral 0.25, 0.50, 1.0, 1.5, or 2.0 mg/eye dose. In addition, the pharmacokinetics and toxicological properties of NX1838 were determined following six biweekly bilateral injections of 0.25 or 0.50 mg/eye or following four biweekly bilateral injections of 0.10 mg per eye followed by two biweekly bilateral injections of 1.0 mg per eye. Results. Plasma and vitreous humor NX1838 concentrations were linearly related to the dose administered. NX1838 was cleared intact from the vitreous humor into the plasma with a half-life of approximately 94 h, which was in agreement with the plasma terminal half-life. Vascular endothelial growth factor (VEGF)-binding assays demonstrated that the NX1838 remaining in the vitreous humor after 28 days was fully active. No toxicological effects or antibody responses were evident. Conclusions. The no observable effect level was greater than six biweekly bilateral 0.50 mg/eye doses or two biweekly bilateral 1.0 mg/eye doses. These pharmacokinetic and safety data support monthly 1 or 2 mg/eye dose regimens in human clinical trials.
- Published
- 2000
- Full Text
- View/download PDF
49. Bond Activation by a Bimetallic GaIComplex: Avenue to Intermetallic Compounds
- Author
-
Helling, Christoph, Farmer, James C., Wölper, Christoph, Kretschmer, Robert, and Schulz, Stephan
- Abstract
The synchronous participation of proximate metal centers in bimetallic complexes in a chemical transformation allows for the realization of otherwise unfeasible reaction pathways. Here, we investigated the potential of the bimetallic GaIcomplex CyL2Ga2(1, CyL2= 1,2-trans-C6H10[NC(Me)C(H)C(Me)N(Dip)]2, Dip = 2,6-i-Pr2C6H3) for the construction of intermetallic compounds by bond activation reactions of organometallic group 13 and 15 compounds. Compound 1reacts with GaMe3with insertion into two Ga–C bonds and formation of CyL2(GaMe)2GaMe (3), whereas the reaction with BiEt3only proceeds with activation of one Bi–C bond and formation of CyL2Ga(Et)Ga(BiEt2) (4). Reactions of 1with Sb2Et4and Bi2Ph4occurred with the insertion of both Ga centers into the E–E bonds and formation of CyL2(GaER2)2(ER2= SbEt26, BiPh27) with E–Ga–Ga–E motifs. Compounds 3–7were characterized by heteronuclear NMR (1H, 13C{1H} (except 4)) and infrared (IR) spectroscopy as well as elemental analysis, and their solid-state structures were determined by single-crystal X-ray diffraction (sc-XRD). The structural features of the complexes hint at differing reaction pathways involving the two proximate GaIcenters, which were additionally studied by quantum chemical calculations.
- Published
- 2022
- Full Text
- View/download PDF
50. Are climate risks encouraging cover crop adoption among farmers in the southern Wabash River Basin?
- Author
-
Yoder, Landon, Houser, Matthew, Bruce, Analena, Sullivan, Abigail, and Farmer, James
- Subjects
COVER crops ,WATERSHEDS ,FARMERS' attitudes ,CASH crops ,FARMERS ,CROPS - Abstract
• Climate-driven risks were an emerging but limited driver of cover crop adoption. • Farmers depicted adoption as creating tradeoffs rather than win-win outcomes. • Climate change may encourage or discourage adoption because of tradeoffs. • Outreach should prioritize involving farmers in shared problem-solving. • Policy changes should help farmers manage adoption tradeoffs to prevent abandonment. Cover crops represent a potential win-win opportunity to promote climate resilience by helping farmers adapt to climate risks while simultaneously mitigating multiple environmental impacts from agriculture. However, cover crop adoption rates are increasing slowly and cover less than 5% of U.S. croplands. In contrast, several Indiana counties in the southern Wabash River Basin have cover crops on more than 20 % of farmland. This qualitative study draws on 33 semi-structured interviews with farmers to understand whether climate risks are driving the above-average rates of adoption in this area. Our purposive sample of farmers was guided by whether they farmed flood-prone areas along the White and Wabash Rivers, thus making them especially sensitive to increasing flood risks from climate change. We found that while climate risks, particularly intensifying rainfall events, were a factor in some cases, most adoption was a longstanding effort to control wind-erosion on hilly areas with sandy soils. We also found that farmers experienced challenges with adoption following successful establishment of cover crops tied to climate-driven ecosystem responses. Greater spring precipitation delayed cash crop planting because of moisture retention and intensified pest pressures from increased habitat has caused replanting of cash crop seeds. Responses indicate that climate risks have mixed effects that may either discourage or encourage cover crop adoption depending on whether future outreach and policy interventions can help farmers overcome the adoption challenges they encounter. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
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