520 results on '"Dong Jian"'
Search Results
2. Semantic-aware automatic extraction method for bottom sediment annotations in raster nautical charts
- Author
-
Ma, Mengkai, Dong, Jian, Tang, Lulu, and Wang, Zimeng
- Abstract
ABSTRACTThe automatic extraction of bottom sediment annotations in large-scale raster nautical charts has limitations, including an imprecise semantic information description and low efficiency. To overcome them, we propose a convolutional neural network (CNN)-based method for the automatic extraction of bottom sediment annotations in raster nautical charts, using image processing techniques to improve it. First, an adaptive chart partitioning model that considers element completeness is constructed. Second, a principle for the unique identification of elements based on spatial conflicts is designed. Finally, a model for accurately extracting semantic information for bottom sediment annotations is established. To evaluate the effectiveness of the proposed method, we implemented a model based on the PyTorch framework and used the PIL library to analyze the results. We also conducted comparative experiments on multiple CNN models to recommend the selection of such models in the proposed method by comparing their classification and recognition performance. The experimental results indicate that (1) the proposed model can achieve high-precision extraction of bottom sediment annotations in raster nautical charts. (2) Furthermore, the proposed model generally has high recognition accuracy and semantic completeness, with better recognition precision than traditional pattern recognition methods.
- Published
- 2024
- Full Text
- View/download PDF
3. Surface roughness and fracture cracks of Al2O3/TiO2composite coating by wet chemical mechanical grinding with structured abrasives pad
- Author
-
Yao, Weifeng, Chen, Zhan, Yang, Jianguo, Zhou, Fenfen, Zhang, Tianqi, Dong, Jian, and Zhang, Yuhui
- Abstract
In the fields of wind power, and other industries, the Al2O3/TiO2coating is prepared and ground on the bearing ring, in order to obtain the insulation resisting the electrical erosion for the motors at high voltage. A novel wet chemical mechanical grinding (WCMG) method is proposed to finish this hard-brittle composite material, utilizing the structured diamond abrasives pad and the NaOH solution. The softened workpiece's surface under the chemical reaction was demonstrated by means of Raman spectrum, indentation and scratching tests. The analytical model of surface roughness and fracture cracks is established based on the synthesis of geometry and kinematics, contact mechanics, material removal and indentation fracture mechanics. The surface roughness of coating was reduced from initial Sa3.293 μm down to final Sa0.049 μm in the WCMG process with grain size 3 μm and pH 12.01, mostly attributed to the ductile removal of chemically softened coating surface.
- Published
- 2024
- Full Text
- View/download PDF
4. Short-term oxidation behavior of powder metallurgy Al0.8Co0.5Cr1.5CuFeNi HEA in high-temperature solid and semi-solid intervals.
- Author
-
Huang, Minjie, Jiang, Jufu, Wang, Ying, Liu, Yingze, Zhang, Ying, and Dong, Jian
- Subjects
ALUMINUM oxide ,OXIDATION - Abstract
• Oxide scales are mainly composed of α-Al 2 O 3 and no obvious internal oxidation occurs in both solid and semi-solid intervals. • During solid oxidation, different scale formation kinetics occurs on various phases, which is caused by outward Al
3+ diffusion rate difference in various component systems. • Increased degree of chaos and number of vacancies in liquid phase contribute to the rise of oxygen diffusion rate and flux, causing the oxidation corrosion around liquid phase region. • Oxidation resistance in semi-solid state attributes to dense Al 2 O 3 scales formed by selective oxidation of Al. In this work, possible short-term thermal exposure oxidation in hot processing including semi-solid processing is focused. We aim to investigate the short-term oxidation behavior of a novel powder metallurgy Al 0.8 Co 0.5 Cr 1.5 CuFeNi high entropy alloy (HEA) in high-temperature solid (1000–1100 °C) and semi-solid (1125–1225 °C) intervals. From 1000 to 1225 °C, mass gain increases from 0.31 to 0.45 mg cm–2 after 60 min oxidation, presenting superior oxidation resistance in the semi-solid state compared with other semi-solid alloys. Equiaxed α-Al 2 O 3 grains are the predominant component of oxide scales and no obvious internal oxidation layer occurs in both solid and semi-solid intervals. Al 2 O 3 scale growth is predominantly determined by outward Al3+ diffusion. For solid oxidation, different scale formation kinetics occur on various phases and the BCC(B2) phase has faster scale formation kinetics. This is attributed to outward Al3+ diffusion rate differences in various component systems. During semi-solid oxidation, the increased degree of chaos and number of vacancies in the liquid phase provide a diffusion channel, leading to rapid Al 2 O 3 formation. Oxidation resistance in the semi-solid state is attributed to dense Al 2 O 3 scales formed through selective oxidation of Al. [Display omitted] [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
5. A multiple feature fusion-based intelligent optimization ensemble model for carbon price forecasting
- Author
-
Wang, Jujie, Dong, Jian, Zhang, Xin, and Li, Yaning
- Abstract
Accurately predicting carbon emissions trading price can assist governments in devising policies that strike a balance between economic development and environmental protection. In recent years, the decomposition integration framework has been widely applied for carbon price prediction. However, due to the inadequacy of feature extraction and lack of emphasis on interval forecasting, constructing a stable and efficient forecasting model for carbon price remains a challenging task. Thus, this study proposes an enhanced decomposition integration model for carbon price prediction that conducts multiple feature fusion based on the potential determinants and establishes a multivariate intelligent optimized ensemble model. Firstly, decomposition and entropy algorithms are employed to decompose and reconstruct the carbon price into several simple subsequences to strike the balance between computing speed and the complexity of the model. Subsequently, considering how external factors may affect the sequence, structured data, and unstructured data are both introduced to construct the multiple forecasting model. An intelligent optimization ensemble model is then developed for predicting the reconstructed components based on a deep learning model with an attention mechanism. Lastly, to quantify uncertainty, interval prediction is incorporated for research and analysis. Empirical analysis is conducted on three carbon finance pilot markets in China and the values of Mean Absolute Percentage Error (MAPE) are 2.047, 1.251, and 0.994 respectively. Furthermore, each module of the proposed model significantly contributes to the results and the developed model outperforms the baseline model across various error metrics.
- Published
- 2024
- Full Text
- View/download PDF
6. Creating cold resistant germplasm of potato using Solanum boliviense.
- Author
-
LIU Yuan-Yuan, DONG Jian-Ke, YING Jing-Wen, MEI Wen-Xiang, CHENG Gang, GUO Jing-Jing, JIAO Wen-Biao, and SONG Bo-Tao
- Abstract
Potato cultivars are not tolerant to low temperatures and frost, which directly affects the growth and development of plants and tubers, thus affecting potato yield. Wild potato species, such as S. boliviense, have abundant resources for cold frost resistance, which are important resources for improving cultivated potato varieties. Based on cold resistance identification of different S. boliviense strains, we screened and obtained the excellent strain BLV29-2 (S. boliviense) with comprehensive traits. It was then crossed and backcrossed with the diploid cultivar ED25, resulting in interspecific hybrids with stronger cold resistance. Inter-specific hybrid strains that had shown significant improvement in cold tolerance were treated with recycled colchicine. Cold tolerance and agronomic traits were assessed in some of the strains, and the results showed that all the doubled materials had significant increases in plant height, pollen grain diameter, and individual potato weight. Most of the materials showed there was no significant change in cold tolerance before and after doubling, but significantly improved compared to the cultivated species control. By crossing the treated strain T-FT073-4-7 with the superior tetraploid cultivar Huashu 13, we observed segregation of cold resistance in the offspring, with the 47% of the materials showing a preference towards the maternal parent T-FT073-4-7 and significantly higher cold resistance compared to the paternal cultivar. Through further field evaluations of agronomic traits, we identified selected breeding materials with the improved overall traits and the significantly enhanced cold resistance. This study successfully introduced the excellent cold resistance of the diploid wild species S. boliviense into the tetraploid cultivar, thus addressing the deficiency of the existing cultivar in terms of low-temperature sensitivity. These findings provide an important foundation for the selection and further improvement of cold-resistant genetic breeding materials. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. Influence of Fertilization Methods and Types on Wheat Rhizosphere Microbiome Community and Functions.
- Author
-
Cui, Chao, Li, Fang, Zeng, Quan, Li, Chenyang, Shen, Wei, Gao, Xiang, Li, Xiaoyan, Zhao, Wanchun, Dong, Jian, Li, Jiangang, and Yang, Mingming
- Published
- 2024
- Full Text
- View/download PDF
8. Post-processing denoising of low-dose CT images based on GAN network
- Author
-
Bilas Pachori, Ram, Chen, Lei, Zhang, Siyuan, Dong, Jian, and Li, Shuang
- Published
- 2024
- Full Text
- View/download PDF
9. Chart quality detection method based on depth range constraints in isobath zones
- Author
-
Sohrabi, Hormoz, Lohani, Tarun Kumar, Tang, Lulu, Zhang, Lihua, Dong, Jian, Wang, Dong, and Jia, Shuaidong
- Published
- 2024
- Full Text
- View/download PDF
10. On-Chip Topological Photonic Crystal Nanobeam Filters.
- Author
-
Liu, Mo-Dian, Chen, Hou-Hong, Wang, Ziyu, Zhang, Yong, Zhou, Xin, Tang, Guo-Jing, Ma, Fei, He, Xin-Tao, Chen, Xiao-Dong, and Dong, Jian-Wen
- Published
- 2024
- Full Text
- View/download PDF
11. Polydopamine Nanostructure-Enhanced Water Interaction with pH-Responsive Manganese Sulfide Nanoclusters for Tumor Magnetic Resonance Contrast Enhancement and Synergistic Ferroptosis–Photothermal Therapy.
- Author
-
Ma, Guiqi, Zhang, Xinyu, Zhao, Kunlong, Zhang, Shuxuan, Ren, Ke, Mu, Mengyao, Wang, Chenyu, Wang, Ximing, Liu, Hui, Dong, Jian, and Sun, Xiao
- Published
- 2024
- Full Text
- View/download PDF
12. Metalens-array-based integral-imaging near-eye display
- Author
-
Lee, Jiun-Haw, Wang, Qiong-Hua, Liu, Xia, Fan, Zhi-Bin, Cheng, Yun-Fan, Chen, Ze-Ming, Lu, Wen-Long, Li, Shi-Hao, Jiang, Shao-Ji, Qin, Zong, and Dong, Jian-Wen
- Published
- 2024
- Full Text
- View/download PDF
13. Effect of casting process and Zr, V addition on microstructure and mechanical properties of Al–12Si-4.5Cu–2Ni alloy
- Author
-
Dong, Jian, Jiang, Jufu, Wang, Ying, Huang, Minjie, Cui, Jingbo, Qin, Tianxiang, and Kong, Lingbo
- Abstract
The casting process, the type and content of microalloying elements have a significant effect on the microstructure and mechanical properties of Al–12Si-4.5Cu–2Ni alloy. The results showed that with the increase of Zr and V, the grain size and secondary dendrite arm spacing (SDAS) of the alloy decreased. However, excessive Zr and V led to abnormal growth of the intermetallic phase, resulting in the separation phenomenon of the matrix. Compared with gravity casting, squeeze casting not only inhibited the segregation of alloying elements but also refined the size of the intermetallic phase. The mechanical properties of the alloy showed a trend of increasing first and then decreasing. When the content of Zr and V was 0.2, the Al–12Si-4.5Cu–2Ni alloy obtained the best mechanical properties. The ultimate tensile strength, yield strength and elongation were 261.4 MPa, 150.2 MPa and 1.93 %, respectively. The (AlSi)3(ZrV), stacking faults and dislocations in the alloy significantly improved the mechanical properties. The disappearance of pores and the refinement of microstructure elevated the elongation of the alloy, while the dotted intermetallic phase accelerated the initiation of microcracks, leading to a decrease in elongation.
- Published
- 2024
- Full Text
- View/download PDF
14. Kinetic Hydrate Inhibition of Poly(N-isopropylacrylamide) and Poly(N-isopropylmethacrylamide): A Comprehensive Analysis of Amphiphilicity and Hydrogen Bonding Effect
- Author
-
Wang, Dong, Kelland, Malcolm A., Xu, Ying, Wang, Xin, Lu, Ping, and Dong, Jian
- Abstract
Rapid formation of natural gas clathrate hydrates has been a significant hazard in off-shore natural gas drilling and gas transport. During operation, polymer inhibitors can serve as low-dosage kinetic inhibitors to prevent the formation of gas hydrates. A comprehensive consideration of the multiple factors involved in the actions of kinetic hydrate inhibitors (KHIs) can elucidate the inhibiting behavior of polymers. Here, amphiphilic poly(N-isopropylmethacrylamide) (PNIPMAm) (or poly(N-isopropylacrylamide)) are found to achieve weak to strong inhibition by the variable superimposed effect of the polymer’s amide group and hydrophobic effect of the polymer’s alkyl groups on the aqueous phase. The interfacial and bulk water mobility and hydrogen bonding energy in the polymer solutions are compared by low-temperature nuclear magnetic resonance (NMR) relaxometry. The mobility of the water is found to be sensitive to the hydrophobic α-methyl side group in PNIPMAm and its molecular weight when a guest molecule tetrahydrofuran is present. The water hydrogen bonding energies measured from NMR are also associated with the nonfreezable bound water amount revealed by differential scanning calorimetry. The α-methyl side group leads to a significant reduction of the water mobility, an increase in the hydrogen bonding energies of the interfacial water, and a decrease of the hydrate growth rate constants by 2 to 3 orders of magnitude. The retarded reaction kinetics of heterogeneous hydrate growth can be related to the hydrophobic effect of the polymer’s α-methyl side group and bound water properties (mobility and amount) in the interface.
- Published
- 2024
- Full Text
- View/download PDF
15. Polydopamine Nanostructure-Enhanced Water Interaction with pH-Responsive Manganese Sulfide Nanoclusters for Tumor Magnetic Resonance Contrast Enhancement and Synergistic Ferroptosis–Photothermal Therapy
- Author
-
Ma, Guiqi, Zhang, Xinyu, Zhao, Kunlong, Zhang, Shuxuan, Ren, Ke, Mu, Mengyao, Wang, Chenyu, Wang, Ximing, Liu, Hui, Dong, Jian, and Sun, Xiao
- Abstract
Rational structure design benefits the development of efficient nanoplatforms for tumor theranostic application. In this work, a multifunctional polydopamine (PDA)-coated manganese sulfide (MnS) nanocluster was prepared. The polyhydroxy structure of PDA enhanced the water interaction with pH-responsive MnS nanoclusters via hydrogen bonds. At pH 5.5 conditions, the spin–lattice relaxation rate of MnS nanoclusters dramatically increased from 5.76 to 19.33 mM–1·s–1after the PDA coating, which can be beneficial for efficient tumor magnetic resonance imaging. In addition, PDA endowed MnS nanoclusters with excellent biocompatibility and good photothermal conversion efficiency, which can be used for efficient tumor photothermal therapy (PTT). Furthermore, MnS nanoclusters possess the ability to release H2S in the acidic tumor microenvironment, effectively inhibiting mitochondrial respiration and adenosine triphosphate production. As a result, the expression of heat shock protein was obviously reduced, which can reduce the resistance of tumor cells to photothermal stimulation and enhance the efficacy of PTT. The released Mn2+also displayed efficient peroxidase and glutathione oxidase-like activity, effectively inducing tumor cell ferroptosis and apoptosis at the same time. Therefore, this nanoplatform could be a potential nanotheranostic for magnetic resonance contrast enhancement and synergistic ferroptosis–PTT of tumors.
- Published
- 2024
- Full Text
- View/download PDF
16. Quantifying robustness against sharp bending in an integrated topological interface of valley photonic crystals
- Author
-
Guo, Chao-Heng, Tang, Guo-Jing, Li, Meng-Yu, Chen, Wen-Jie, He, Xin-Tao, and Dong, Jian-Wen
- Abstract
Sharp-bending waveguide is a key element for ultra-compact and densely integrated photonic devices, which is promising to enlarge the capability of modern information processing in a single chip. Topological photonics manifest the nature of robust propagation against sharp bending and such robustness has been experimentally demonstrated in topological integrated interfaces. It is important to quantify the bending loss of topological interface but has remained exclusive. In this work, we report on the characterization of sharp-bending robustness in the integrated topological interface of valley photonic crystals (VPCs) by experimentally quantifying the ultralow bending loss. The VPCs are designed on a standard silicon-on-insulator platform with the inversion-symmetry broken in honeycomb lattice, and four types of topological interfaces can be constructed by two topologically-distinct VPCs. As one of the representative cases, zigzag-AA interface is applied to demonstrate the robust propagation along sharp bending. In experiment, we fabricate a series of VPC interfaces with different turn number and the same transmission distance, which perform the ultralow bending loss less than 0.02 dB per 120-deg turning. Furthermore, we experimentally characterize the propagation loss in the integrated interfaces. Our approach not only shows the ability of VPC topological interfaces to suppress backscattering stemming from sharp bending, but also paves the way for topological nanophotonic dense integration.
- Published
- 2024
- Full Text
- View/download PDF
17. Channelwise and Spatially Guided Multimodal Feature Fusion Network for 3-D Object Detection in Autonomous Vehicles
- Author
-
Uzair, Muhammad, Dong, Jian, Shi, Ronghua, Mushtaq, Husnain, and Ullah, Irshad
- Abstract
Accurate 3-D object detection is vital in autonomous driving. Traditional LiDAR models struggle with sparse point clouds. We propose a novel approach integrating LiDAR and camera data to maximize sensor strengths while overcoming individual limitations for enhanced 3-D object detection. Our research introduces the channelwise and spatially guided multimodal feature fusion network (CSMNET) for 3-D object detection. First, our method enhances LiDAR data by projecting it onto a 2-D plane, enabling the extraction of class-specific features from a probability map. Second, we design class-based farthest point sampling (C-FPS), which boosts the selection of foreground points by utilizing point weights based on geometric or probability features while ensuring diversity among the selected points. Third, we developed a parallel attention (PAT)-based multimodal fusion mechanism achieving higher resolution compared to raw LiDAR points. This fusion mechanism integrates two attention mechanisms: channel attention for LiDAR data and spatial attention for camera data. These mechanisms enhance the utilization of semantic features in a region of interest (ROI) to obtain more representative point features, leading to a more effective fusion of information from both LiDAR and camera sources. Specifically, CSMNET achieves an average precision (AP) in bird’s eye view (BEV) detection of 90.16% (easy), 85.18% (moderate), and 80.51% (hard), with a mean AP (mAP) of 85.12%. In 3-D detection, CSMNET attains 82.05% (easy), 72.64% (moderate), and 67.10% (hard) with an mAP of 73.75%. For 2-D detection, the scores are 95.47% (easy), 93.25% (moderate), and 86.68% (hard), yielding an mAP of 91.72% for the KITTI dataset.
- Published
- 2024
- Full Text
- View/download PDF
18. Structure-Preserving Nonstaggered Central Difference Schemes at Wet-Dry Fronts for the Shallow Water Equations
- Author
-
Dong, Jian and Qian, Xu
- Abstract
We aim to propose a Riemann-problem-solver-free nonstaggered central difference scheme (NCDS), which is well-balanced and positivity-preserving for two-dimensional shallow water flows over nonflat bottom topography with wet-dry fronts. The well-balanced property of the NCDS for the two-dimensional shallow water equations at wet-dry fronts is still unclear. The NCDS is “generously multidimensional” and consists of three steps: a forward step, a corrector step, and a backward step. Each step needs to guarantee the water depth to be nonnegative and retain the lake at rest. The key ingredient of the NCDS is the backward step. It is very nontrivial and technical to obtain both the well-balanced and positivity-preserving properties when the computational domain contains wet-dry fronts for the NCDS. The traditional NCDS fails to retain the lake at rest when the computational domain contains wet-dry fronts. We introduce a novel backward step, which is well-balanced and positivity-preserving, to recover numerical solutions on nonstaggered cells. Finally, we show several numerical results of two-dimensional shallow water equations with wet-dry fronts to verify these properties.
- Published
- 2024
- Full Text
- View/download PDF
19. Detection of redox potential evolution during the initial stage of an acute wound based on a redox-sensitive SERS-active optical fiberElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d4ay00095a
- Author
-
Zhang, Shuyu, Ji, Lingling, Xu, Kun, Xiong, Xiulei, Ai, Bingwei, Qian, Weiping, and Dong, Jian
- Abstract
To detect redox potential evolution during the initial stage of an acute wound, a redox-sensitive SERS-active optical fiber was fabricated by integrating redox-sensitive SERS probes in a hole of an optical fiber. The redox-sensitive SERS-active optical fibers carried redox-sensitive SERS probes into the inside of a wound to sense its redox potential. The laser was transmitted to the redox-sensitive SERS probes in the body by optical fibers, and the SERS signals of the redox-sensitive SERS probes were transferred out of the body by optical fibers to indicate the redox potentials in the wound. The redox-sensitive SERS probes dynamically sensed the redox potential in vivo, and their SERS signals were collected constantly to indicate the redox potentials. The assessments in vivoand in vitroproved the responsiveness of redox-sensitive SERS-active optical fibers. The redox potential evolution during the initial stage of an acute wound with the treatments of different concentrations of glucose was detected to verify the feasibility of redox-sensitive SERS-active optical fibers to dynamically detect redox potentials in vivo. The redox-sensitive SERS-active optical fiber would be a versatile tool to explore the roles of redox potentials in living organisms.
- Published
- 2024
- Full Text
- View/download PDF
20. Radar Signal Sorting With Multiple Self-Attention Coupling Mechanism Based Transformer Network
- Author
-
Zhou, Zixiang, Fu, Xiongjun, Dong, Jian, and Gao, Meijing
- Abstract
In modern electromagnetic countermeasure environments, traditional radar signal sorting (RSS) methods face challenges from incompletely intercepted parameter-dense pulses of multi-function radars (MFRs). To cope with this situation, this letter proposes a sequence-to-sequence RSS method based on a multiple self-attention coupling mechanism Transformer network. The method utilizes positional encoding to obtain stable temporal information. A multiple self-attention coupling mechanism is then designed to calculate the attention matrix, thereby extracting sequence relationships for the non-ideal pulse stream. Finally, a decoder network is employed to extract high-dimensional features and translate the corresponding labels for each pulse. Simulation experiments demonstrate that compared with some existing methods, the proposed method can achieve better average sorting accuracy with little computational cost under the conditions of overlapping parameters, limited label, missing pulses, and various modulation types of intercepted MFR signals.
- Published
- 2024
- Full Text
- View/download PDF
21. HRPnet: High-Dimensional Feature Mapping for Radar Space Target Recognition
- Author
-
Dong, Jian, She, Qingqing, and Hou, Feifei
- Abstract
Deep learning has made significant progress in the field of radar space target recognition. However, deep neural networks require significant amounts of data to train network parameters, posing challenges in achieving noncooperative target recognition. Therefore, it is of practical significance to research a fast and accurate target recognition method with limited radar data. In this article, we propose a novel radar space target recognition network based on high-dimensional feature maps, called HRPnet, which fully utilizes high-resolution range profile (HRRP), radar cross section (RCS), and polarization (POL) data obtained from the radar. First, a sparse autoencoder (SAE) is employed to conduct deep feature extraction on the three types of data. Second, the Gramian angular field (GAF) transformation is employed to obtain 2-D representation of HRRP, RCS, and POL data, respectively. These 2-D maps are then integrated to construct high-dimensional feature maps. Third, a feature map convolutional neural network (FMCNN) is designed for high-dimensional feature map classification and target recognition. Experimental results indicate that the proposed HRPnet outperforms existing methods in terms of recognition accuracy and noise resistance, particularly in the case of a limited sample size.
- Published
- 2024
- Full Text
- View/download PDF
22. On a class of weak R-duals and the duality relations
- Author
-
Li, Yun-Zhang and Dong, Jian
- Abstract
The concept of R-duals of a sequence was first introduced with the motivation to obtain a general version of duality principle in Gabor analysis. Since then, various R-duals (types II, III, IV) and some relaxations of the R-dual setup have been introduced and studied by some mathematicians. All these “R-duals” provide a powerful tool in the analysis of duality relations in general frame theory. It is of independent interest in mathematics and far beyond the duality principle in Gabor analysis. Observe that the underlying sequences of a R-dual are a pair of orthonormal bases. In this paper we introduce the concept of weak R-duals based on a pair of Parseval frames. It is a new relaxation of the R-dual setup. We obtain a characterization of frames based on their weak R-duals, and prove that the weak R-dual of a frame (Riesz basis) is a frame sequence (frame). We also characterize (unitarily) equivalent frames in terms of weak R-duals. Finally, we present an explicit expression of the canonical duals of weak R-duals.
- Published
- 2024
- Full Text
- View/download PDF
23. XJB-5-131 protects chondrocytes from ferroptosis to alleviate osteoarthritis progression via restoring Pebp1 expression
- Author
-
Sun, Wei, Lv, Zhongyang, Li, Weitong, Lu, Jun, Xie, Ya, Wang, Peng, Jiang, Ruiyang, Dong, Jian, Guo, Hu, Liu, Zizheng, Fei, Yuxiang, Tan, Guihua, Wang, Maochun, Ren, Kewei, Xu, Jun, Sun, Huiqing, Jiang, Xuefeng, and Shi, Dongquan
- Abstract
Osteoarthritis (OA) is the most common age-related musculoskeletal disease. However, there is still a lack of therapy that can modify OA progression due to the complex pathogenic mechanisms. The aim of the study was to explore the role and mechanism of XJB-5-131 inhibiting chondrocytes ferroptosis to alleviate OA progression.
- Published
- 2024
- Full Text
- View/download PDF
24. CdSe/TiO2NTs Heterojunction-Based Nonenzymatic Photoelectrochemical Sensor for Glucose Detection.
- Author
-
Li, Yue-Liu, Tian, Jing, Shi, Dong-Jie, Dong, Jian-Xun, Yue, Zhao, Li, Geng, Huang, Wei-Ping, Zhang, Shou-Min, and Zhu, Bao-Lin
- Published
- 2023
- Full Text
- View/download PDF
25. ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.
- Author
-
An, Xueying, Wu, Wenshu, Yang, Lin, Dong, Jian, Liu, Bin, Guo, Junxia, Chen, Jianmei, Guo, Baosheng, Cao, Wangsen, and Jiang, Qing
- Abstract
Aberrant N6-methyladenosine (m6A) modification of mRNAs contributes significantly to the epigenetic tumorigenesis, however, its precise role and the key targets in osteosarcoma (OS) are not defined. Here we reported that selective METTL3 (methyltransferase like 3) elevation and the consequential increase of m6A modification causally affect OS progression. The fast-growing OS cells displayed preferential upregulation of METTL3 and increased m6A modification. Conversely, m6A inhibition by 3-deazaadenosine, siRNA-mediated METTL3 knockdown or a METTL3-selective inhibitor STM2457 effectively inhibits OS cell growth and induced OS cell apoptosis. Further investigation revealed that an oncogenic protein ZBTB7C was likely a critical m6A target that mediated the oncogenic effects. ZBTB7C mRNA contains a typical m6A motif of high confidence and its mRNA and protein were enriched with increased m6A modification in OS samples/cells. In an OS xenograft model, STM2457 or siRNA-mediated METTL3 knockdown effectively lowed ZBTB7C abundance. More importantly, the anti-OS effects of STM2457 were significantly reduced when ZBTB7C was overexpressed by lentivirus. Together, our results demonstrate that the METTL3 aberration and the resultant ZBTB7C m6A modification form an important epigenetic regulatory loop that promotes OS progression, and targeting the METTL3/ZBTB7C axis may provide novel insights into the potential strategies for OS therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
26. Is it safe for the spinal metastasis patients with preoperative deep vein thrombosis to use low-molecular-weight heparin before surgery? A prospective study.
- Author
-
Jiang, Yun-qi, Wang, Ling-yan, Hu, Shun-qi, Li, Xi-lei, Zhou, Jian, Qi, Qing, and Dong, Jian
- Abstract
• Administration of LMWH before surgery did not increase the risk of perioperative bleeding. • The study revealed a prevalence of preoperative DVT of 8.0% in patients with spinal metastasis. • Preoperative D-dimer may not be a perfect predictor of preoperative DVT for patients with spinal metastasis. S pine surgeons should weigh the risks of anticoagulants against their benefits in preventing deep venous thrombosis (DVT), as they may increase the risk of bleeding. Spinal metastasis patients undergoing decompression with fixation are at a high risk for DVT, which may occur preoperatively. Therefore, anticoagulants should be administered preoperatively. This study aimed to evaluate the safety of the administration of anticoagulants in treating spinal metastasis patients with preoperative DVT. Therefore, we prospectively investigated the prevalence of DVT in these patients. Patients who were diagnosed with preoperative DVT were included in an anticoagulant group. Subcutaneous low-molecular-weight heparin (LMWH) was administered. Patients without DVT were included in a non-anticoagulant group. Data on patient information, clinical parameters, blood test results, and bleeding complications were also collected. Moreover, the safety of anticoagulants was analyzed. The prevalence of preoperative DVT was 8.0%. None of the patients developed pulmonary thromboembolism. Furthermore, no significant differences in blood loss, drainage volume, hemoglobin levels, number of transfusions, or preoperative trans -catheter arterial embolization were observed between the two groups. None of the patients developed major bleeding. However, two patients experienced wound hematoma and one experienced incisional bleeding in the non-anticoagulant group. Therefore, LMWH is safe for spinal metastasis patients. Future randomized controlled trials should be conducted to evaluate the validity of perioperative prophylactic anticoagulation therapy in these patients. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
27. Optimization Design of High-Dimensional Parameters MIMO Antenna in Semantic-Based Mobile Applications
- Author
-
Li, Qianqian and Dong, Jian
- Abstract
To ensure the quality of semantic communication, an optimization scheme for multiple-input and multiple-output (MIMO) antenna design using in semantic-based mobile is proposed and verified. The scheme is based on a modified algorithm MOEA/D-BH, which integrates the black-hole (BH) algorithm into multi-objective EA based on decomposition (MOEA/D). By introducing controllable absorption distance and neighborhood learning mechanism, MOEA/D-BH can deal with high-dimension parameters well in a multi-objective optimization problem. Thus, in a limited design space, a satisfied antenna can be optimized by proposed scheme efficiently. This can be a feasible candidate scheme for MIMO antenna design. A single-band and dual-band MIMO antenna, which are applied for semantic-based mobile system, are optimized by proposed scheme sharing the same model. Both the data of simulation and measurement show good electrical and MIMO performances in the working frequency band. Thus not only the performance of the semantic communication definitely improved, but also it provides useful exploration for the development of intelligent semantic mobile systems.
- Published
- 2023
- Full Text
- View/download PDF
28. Phase transition and bond symmetrization associated with noble gas bond in XeO3
- Author
-
Zhang, Xu, Dong, Jian, Lu, Min, and Hou, Chun-Ju
- Published
- 2023
- Full Text
- View/download PDF
29. Anti-Jamming Algorithm of Polarization-Sensitive Array Based on Improved Constraint Matrix and Orthogonal Subspace Projection
- Author
-
Wang, Meng, Luo, Xiaoxuan, and Dong, Jian
- Abstract
The vulnerability of satellite navigation signals to suppressive interference is a major concern owing to the extremely low power. The polarization-sensitive array adds polarization diversity capability, providing outstanding anti-jamming properties. Null depth is a crucial indicator of interference mitigation capability. This article proposes a new weight vector calculation method for space-polarization-domain adaptive processing (SPAP) by focusing on interference null depth, which can improve the anti-interference performance of polarization-sensitive arrays. First, the realistic received signal model of the polarization-sensitive array is built. Second, the realistic radiation pattern of the crossed dipole antenna and the polarization characteristics of the signal are considered in the constraint matrix of the minimum variance distortionless response (MVDR) to obtain a new anti-jamming weight matrix. Finally, the orthogonal projection subspace method is introduced to effectively deepen the interference null, and its orthogonality with the interference subspace is improved by projecting the new anti-interference weight matrix into the noise subspace of the received signal, and the rationality and effectiveness of the method are verified by theoretical derivation. Through simulation experiments on a uniform linear array (ULA) and a uniform circular array (UCA), the results indicate that the proposed method can effectively increase the null depth in the space and polarization domains by 12–28 dB, which significantly improves the array’s anti-interference capability.
- Published
- 2023
- Full Text
- View/download PDF
30. An Ultrawideband Miniaturized Ultrathin Flexible Metamaterial Absorber Using Lightweight ITO Film
- Author
-
Dong, Jian, Ma, Yan, and Wang, Meng
- Abstract
This letter presents an ultrawideband miniaturized ultrathin flexible metamaterial absorber (MMA) based on frequency selective surface (FSS). The proposed MMA consists of an inner planar helix and four groups of outer convoluted lightweight indium tin oxide resistive film etched on a transparent substrate polyethylene terephthalate substrate. The MMA demonstrates stable absorption across the frequency range of 1.98 to 25.88 GHz, achieving a remarkable maximum fractional bandwidth of 171.6%. The unit cell size of the MMA is 0.06
×0.06${\lambda }_L$ ×0.035${\lambda }_L$ , where${\lambda }_L$ represents the wavelength corresponding to the lowest absorption frequency. The structure can cover both the L- and S-bands without increasing its size and achieve stable absorption under a curved surface. Therefore, it is suitable for low-frequency applications such as satellite navigation systems and satellite communications.${\lambda }_L$ - Published
- 2023
- Full Text
- View/download PDF
31. Chronic Remote Ischemic Conditioning on Mild Hypertension in the Absence of Antihypertensive Medication: A Multicenter, Randomized, Double-Blind, Proof-of-Concept Clinical Trial.
- Author
-
Guo, Wenting, Zhao, Wenbo, Li, Dong, Jia, Haiying, Ren, Changhong, Li, Sijie, Zhao, Jing, Yu, Bingxin, Dong, Jian, Guo, Rongfen, Zhu, Kun, Cao, Yu, Wang, Yan, Wang, Ying, Li, Zunshan, Wang, Zhen, Wang, Dan, Hou, Chengbei, Hausenloy, Derek J, and Chu, Xi
- Abstract
Background: Exploratory studies have shown that remote ischemic conditioning (RIC) has the potential to lower blood pressure (BP). We investigated whether chronic RIC reduces BP for hypertension. Methods: This is a multicenter, randomized, double-blind, parallel-controlled trial. Patients with an office BP of 130/80 to 160/100 mm Hg and a 24-hour average BP ≥125/75 mm Hg not on antihypertensive medications were recruited. After a 1-week compliance screening phase, they were randomly assigned in a 1:1 ratio to receive RIC or sham RIC twice daily for 4 weeks. The primary efficacy outcome was the change in 24-hour average systolic BP from baseline to 4 weeks. Safety events were assessed over the study period. Results: Ninety-five participants were randomly allocated to the RIC (n=49) and sham RIC (n=46) groups. In the intention-to-treat analysis, the reduction in 24-hour average systolic BP was greater in the RIC group than the sham RIC group (−4.6±9.5 versus −0.9±6.8 mm Hg; baseline-adjusted between-group mean difference: −3.6 mm Hg [95% CI, −6.9 to −0.3 mm Hg]; adjusted P =0.035). The per-protocol analysis showed that 24-hour average systolic BP reduced −5.9±8.6 mm Hg in the RIC group and −0.7±6.7 mm Hg in the sham RIC group (baseline-adjusted between-group mean difference: −5.2 mm Hg [95% CI, −8.5 to −1.9 mm Hg]; adjusted P =0.002). No major adverse events were reported in both groups. Conclusions: RIC is safe in patients with mild hypertension and may lower BP in the absence of antihypertensive medications. However, the effects of RIC on clinical outcomes in these patients require further investigation. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04915313. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
32. Multifunctional Janus Nanoplatform for Efficiently Synergistic Theranostics of Rheumatoid Arthritis.
- Author
-
Liu, Yuyi, Chen, Liang, Chen, Zhiyang, Liu, Minchao, Li, Xilei, Kou, Yufang, Hou, MengMeng, Wang, Huiren, Li, Xiaomin, Tian, Bo, and Dong, Jian
- Published
- 2023
- Full Text
- View/download PDF
33. Key Factors to Attract More U.S. Diagnostic Radiology Residents into the Field of Nuclear Medicine and Molecular Imaging: A National Survey.
- Author
-
Kako, Bashar, Dong, Jian W., An, Brian P., McLoud, Theresa C., Durfee, Sara M., Jacene, Heather A., Chow, David Z., Wang, Yingbing, Hyun, Hyewon, and Ng, Thomas S.C.
- Abstract
To understand the current state of radiology residents' exposure to nuclear medicine and molecular imaging (NM/MI), determine key factors that may attract more trainees into the field, and identify differentiating aspects between those specializing in NM/MI and those who are not. An anonymous web-based survey was sent to contacts at all diagnostic radiology residency programs in the United States for dissemination to their residents, collecting information about trainees' NM/MI exposure during residency and factors that may attract them to NM/MI. A total of 198 trainees responded to the survey, 34 of whom plan on pursuing a career in NM/MI. Most trainees reported early exposure to NM/MI during residency; most (97.4%) reported ample exposure to general NM/MI and oncologic studies. Less than 3% of trainees reported adequate exposure to therapies, neurological applications, molecular imaging/research advances, and physics. Respondents reported a need for better quality education (38.9%) and exposure to mentors (28.8%) as ways to attract trainees to NM/MI. Routinely encountered clinical pathology was the most interesting for those specializing in NM/MI (29.4%), whereas lifestyle was the most attractive aspect of NM/MI for those not pursuing a career in the field (27.4%). NM/MI-associated research was the least attractive for those specializing in NM/MI (35.3%), while job market concerns was the least attractive aspect for those not specializing in NM/MI (37.2%). Trainees planning to specialize in NM/MI reported higher satisfaction with their orientation to NM/MI during their first clinical rotation compared to those who do not plan to specialize in the field (3.03/5.00 and 2.67/5.00, respectively, p = 0.04). This survey highlights several factors that training programs and national societies can target to improve interest in NM/MI among radiology residents. We found that optimized education initiatives, including improved orientation to the field, increased mentoring, and career opportunities are essential levers for recruiting radiology trainees into the NM/MI workforce. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
34. A dual‐balanced network for long‐tail distribution object detection
- Author
-
Gong, Huiyun, Li, Yeguang, and Dong, Jian
- Abstract
Object detection on datasets with imbalanced distributions (i.e. long‐tail distributions) dataset is a significantly challenging task. Some re‐balancing solutions, such as re‐weighting and re‐sampling have two main disadvantages. First, re‐balancing strategies only utilise a coarse‐grained global threshold to suppress some of the most influential categories, while overlooking locally influential categories. Second, very few studies have specifically designed algorithms for object detection tasks under long‐tail distribution. To address these two issues, a dual‐balanced network for fine‐grained re‐balancing object detection is proposed. Our re‐balancing strategies are both in proposal and classification logic, corresponding to two sub‐networks, the Balance Region Proposal Network (BRPN) and the Balance Classification Network (BCN). The BRPN sub‐network equalises the number of proposals in the background and foreground by reducing the sampling probability of simple backgrounds, and the BCN sub‐network equalises the logic between head and tail categories by globally suppressing negative gradients and locally fixing the over‐suppressed negative gradients. In addition, the authors advise a balance binary cross entropy loss to jointly re‐balance the entire network. This design can be generalised to different two‐stage object detection frameworks. The experimental mAP result of 26.40% on this LVIS‐v0.5 dataset outperforms most SOTA methods. In this paper, a dual‐balanced network is proposed for long‐tail distribution object detection. The proposal in RPN and the logic in classification networks are balanced, which reduces the AP difference between the head and tail categories and improves detection performance overall.
- Published
- 2023
- Full Text
- View/download PDF
35. 44‐3: Invited Paper:Metalens Array for Integral‐Imaging‐Based Near‐Eye Display
- Author
-
Fan, Zhi-Bin, Cheng, Yun-Fan, Liu, Xia, Lu, Wen-Long, Qin, Zong, and Dong, Jian-Wen
- Abstract
We propose a novel integral‐imaging (II) based near‐eye display (NED) combined with high‐pixel‐density display screen, voxel‐based rendering method and nano‐imprint metalens array. The effect of depth of field in AR and VR of such II‐based NED is shown, and the 3D parallax effect on the real mode is demonstrated. We successfully miniaturize the II‐based NED which shows a great potential using in AR and VR.
- Published
- 2023
- Full Text
- View/download PDF
36. Multifunctional Janus Nanoplatform for Efficiently Synergistic Theranostics of Rheumatoid Arthritis
- Author
-
Liu, Yuyi, Chen, Liang, Chen, Zhiyang, Liu, Minchao, Li, Xilei, Kou, Yufang, Hou, MengMeng, Wang, Huiren, Li, Xiaomin, Tian, Bo, and Dong, Jian
- Abstract
Progress has been made in the application of nanomedicine in rheumatoid arthritis (RA) treatment. However, the whole process of monitoring and treatment of RA remains a formidable challenge due to the complexity of the chronic autoimmune disease. In this study, we develop a Janus nanoplatform (denoted as Janus-CPS) composed of CeO2–Pt nanozyme subunit on one side and periodic mesoporous organosilica (PMO) subunit on another side for simultaneous early diagnosis and synergistic therapy of RA. The Janus nanostructure, which enables more active sites to be exposed, enhances the reactive oxygen species scavenging capability of CeO2–Pt nanozyme subunit as compared to their core–shell counterpart. Furthermore, micheliolide (MCL), an extracted compound from natural plants with anti-osteoclastogenesis effects, is loaded into the mesopores of PMO subunit to synergize with the anti-inflammation effect of nanozymes for efficient RA treatment, which has been demonstrated by in vitrocellular experiments and in vivocollagen-induced arthritis (CIA) model. In addition, by taking advantage of the second near-infrared window (NIR-II) fluorescent imaging, indocyanine green (ICG)-loaded Janus-CPS exhibits desirable effectiveness in detecting RA lesions at a very early stage. It is anticipated that such a Janus nanoplatform may offer an alternative strategy of functional integration for versatile theranostics.
- Published
- 2023
- Full Text
- View/download PDF
37. Preparation of double-modified MIL-53 and its catalytic de-nitration performance
- Author
-
Palanisamy, Thanikaivelan, Boon Han, Lim, Wang, Shu-Qin, Dong, Jian-Xin, and Li, Jin-Meng
- Published
- 2023
- Full Text
- View/download PDF
38. Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment
- Author
-
Hu, Zhi-Chao, Lu, Jia-Qi, Zhang, Tai-Wei, Liang, Hai-Feng, Yuan, Hao, Su, Di-Han, Ding, Wang, Lian, Rui-Xian, Ge, Yu-Xiang, Liang, Bing, Dong, Jian, Zhou, Xiao-Gang, and Jiang, Li-Bo
- Abstract
The electrical microenvironment plays an important role in bone repair. However, the underlying mechanism by which electrical stimulation (ES) promotes bone regeneration remains unclear, limiting the design of bone microenvironment–specific electroactive materials. Herein, by simple co-incubation in aqueous suspensions at physiological temperatures, biocompatible regenerated silk fibroin (RSF) is found to assemble into nanofibrils with a β-sheet structure on MXene nanosheets, which has been reported to inhibit the restacking and oxidation of MXene. An electroactive hydrogel based on RSF and bioencapsulated MXene is thus prepared to promote efficient bone regeneration. This MXene/RSF hydrogel also acts as a piezoresistive pressure transducer, which can potentially be utilized to monitor the electrophysiological microenvironment. RNA sequencing is performed to explore the underlying mechanisms, which can activate Ca2+/CALM signaling in favor of the direct osteogenesis process. ES is found to facilitate indirect osteogenesis by promoting the polarization of M2 macrophages, as well as stimulating the neogenesis and migration of endotheliocytes. Consistent improvements in bone regeneration and angiogenesis are observed with MXene/RSF hydrogels under ES in vivo. Collectively, the MXene/RSF hydrogel provides a distinctive and promising strategy for promoting direct osteogenesis, regulating immune microenvironment and neovascularization under ES, leading to re-establish electrical microenvironment for bone regeneration.
- Published
- 2023
- Full Text
- View/download PDF
39. Highly Sensitive Dual-Band Terahertz Metamaterial Absorber for Biomedical Applications: Simulation and Experiment.
- Author
-
Abdulkarim, Yadgar I., Altintas, Olcay, Karim, Ayoub Sabir, Awl, Halgurd N., Muhammadsharif, Fahmi F., Alkurt, Fatih Özkan, Bakir, Mehmet, Appasani, Bhargav, Karaaslan, Muharrem, and Dong, Jian
- Published
- 2022
- Full Text
- View/download PDF
40. Automatic simplification and merging algorithm of isobaths based on surface simplification
- Author
-
Wang, Yang, Tang, Lulu, Zhang, Lihua, Dong, Jian, and Jia, Shuaidong
- Published
- 2023
- Full Text
- View/download PDF
41. Visible-mid infrared ultra-broadband and wide-angle metamaterial perfect absorber based on cermet films with nano-cone structure
- Author
-
Yang, Fan, Li, Rui-Hao, Tan, Shi-Long, Dong, Jian-Wen, and Jiang, Shao-Ji
- Abstract
Metamaterial absorbers over a broadband spectrum with high absorption, good angular tolerance, and easy configurations have essential importance for optical and optoelectronic devices. In this study, a hybrid metamaterial absorber comprising multilayered cermet thin films (multi-cermet) with tapered structure is designed and experimentally demonstrated. Combining optical interference of multi-cermet films and optical field localization of nano-cone structures, the average absorbance of both simulation and measurement are more than 98% in an ultrabroad bandwidth (300–3000 nm), and the proposed absorber shows a good angular tolerance as well. The composite process of two easy-operated and efficient methods, colloidal lithography, and magnetron sputtering, is employed for large-area fabrication. In addition, owing to flexible polyimide substrate, the proposed absorber also shows good bending and heating resistance, which reflects its potential in engineering application.
- Published
- 2023
- Full Text
- View/download PDF
42. Self-Supervised Learning With Learnable Sparse Contrastive Sampling for Hyperspectral Image Classification
- Author
-
Liang, Miaomiao, Dong, Jian, Yu, Lingjuan, Yu, Xiangchun, Meng, Zhe, and Jiao, Licheng
- Abstract
Contrastive learning (CL) with learnable examples performs outstandingly in data representation. However, when dealing with hard samples, instance-level alignment with excessive uniformity may descend into trivial clusters, especially when confronted with interclass similarity and intraclass diversity in hyperspectral images (HSIs). To solve this problem, we regard prototypical CL as tracing the potential probability density distribution. Then, a novel pretraining method, learnable sparse contrastive sampling (LSCoSa), is proposed for discriminative representation learning, containing sparse positive sampling and multiple positives learning. Specifically, on the basis of cooperative–adversarial CL, we first exert a Kullback–Leibler (KL) divergence regularizer on the average activation probability of the prototypes, suppressing fake density prototypes for sparse positive sampling. Furthermore, we propose multiple positives learning, in which the top-
$k$ https://github.com/sakurashine/LSCoSa .- Published
- 2023
- Full Text
- View/download PDF
43. A Novel Radar Signals Sorting Method via Residual Graph Convolutional Network
- Author
-
Lang, Ping, Fu, Xiongjun, Dong, Jian, Yang, Huizhang, and Yang, Jian
- Abstract
The dense, complex and variable electromagnetic environment poses a serious challenge to radar signal sorting (RSS) in modern electronic reconnaissance systems. In order to improve RSS performance, this letter proposes a semi-supervised learning framework-based RSS method via a residual graph convolutional network (ResGCN-RSS) to effectively improve the generalization ability of the signal sorting models in small data scenarios. Firstly, the graph structure construction of intercepted radar signals is performed via K-nearest neighbor algorithm. Then, the three-layer ResGCN is designed to adaptively improve the features learning. Finally, RSS can be effectively and efficiently implemented through an end-to-end ResGCN with small labeled graph data of interleaved radar signals. The simulation experimental results show that our proposed method can achieve better average accuracy with little computational cost increasing when the labeled data is very small, compared to some existing methods.
- Published
- 2023
- Full Text
- View/download PDF
44. Study on tungsten sintering temperature field based on electromagnetic simulation and computational fluid dynamics
- Author
-
Wang, Lu-Yan, Yu, Yue-Guang, Dong, Jian-Xin, Du, Kai-Ping, Liu, Shan-Yu, and Li, Cao-Bing
- Abstract
In order to study the influence of various sintering variables more intuitively and clearly, electromagnetic field analysis and computational fluid dynamics are used to analyze the influence of gas flow, heating power and other process parameters on the temperature range of medium-frequency sintering in this paper. The results indicate that the uniformity of temperature field is determined by the gas flow rate and heating power. When the heating power is 50 kW, the stable temperature drops about 10 K for every 1 m3·h−1increase of hydrogen flow. The peak value of the maximum temperature difference on the tungsten rods gradually increases with the increase of the hydrogen flow rate, and it appears slightly later. The temperature distribution of tungsten rods in furnace is similar with different hydrogen flow rate. At the same time, the closer to the furnace wall, the higher the temperature of the tungsten rod. The temperature difference between tungsten rods mainly occurred within 1 h after the beginning of heating. Increasing the heating power can improve the stable temperature, but has little effect on the heating time. Increasing heating power can increase the peak value of the maximum temperature difference on the tungsten rods, but has little effect on the occurrence time of the peak value of the maximum temperature difference on the tungsten rods. Increasing the heating power will increase the temperature difference of a single tungsten rod, but the temperature difference of a single tungsten rod never exceeds 65 K. This study can be used to guide the process optimization design. Combined with numerical simulation calculation, the sintering parameters with low energy consumption and high temperature uniformity can be quickly and effectively found, thus improving the microstructure and properties of sintered tungsten products.
- Published
- 2023
- Full Text
- View/download PDF
45. Self-assembled nanomaterials for ferroptosis-based cancer theranostics
- Author
-
Ma, Guiqi, Wang, Kaiqi, Pang, Xinlong, Xu, Shanbin, Gao, Yuan, Liang, Yubo, Yang, Jiaxin, Zhang, Xinyu, Sun, Xiao, and Dong, Jian
- Abstract
Most ferroptosis nanomedicines based on organic or inorganic carriers have difficulties in further clinical translation due to their serious side effects and complicated preparation. Self-assembled nanomedicines can reduce the biological toxicity caused by additional chemical modifications and excipients, offering better biocompatibility and safety. Ferroptosis therapy is an iron-associated programmed cell death dependent on lipid peroxidation with efficient tumor selectivity and biosafety. Therefore, the application of self-assembled nanomedicines with good biosafety in the ferroptosis treatment of tumors has attracted extensive attention. In this review, recent advances in the field of ferroptosis-based self-assembled nanomaterials for cancer therapy are presented, with emphasis on how these nanomaterial components interact and their distinct mechanisms for inducing ferroptosis in tumor cells, including iron metabolism, amino acid metabolism and CoQ/FSP1, as well as their respective advantages and challenges. This review would therefore help the spectrum of advanced and novice researchers interested in this area to quickly zoom in on the essential information and glean some thought-provoking ideas to advance this subfield in cancer nanomedicine.
- Published
- 2023
- Full Text
- View/download PDF
46. Fine mapping and cloning of a seed shattering gene SH8 in rice (Oryza sativa L.).
- Author
-
WANG Mu-Mu, HE Yan-Fan, ZHENG Yong-Sheng, WANG Hui, WANG Li-Yuan, WANG Dong-Jian, ZHANG Han, and LI Ru-Yu
- Abstract
Seed shattering is an important trait for seed dispersal and reproduction of offspring in wild rice. It is a vital guarantee for seed dispersal and offspring reproduction of wild rice, but easy grain dropping will cause yield loss in domesticated rice production. Although some genes related to seed shattering have been cloned in rice, these genes were not responsible for all phenotype variation of rice seed shattering. In this study, a recombinant inbred line (E6-5) was selected from a cross between an indica variety Pei-kuh and an Asian common wild rice W1944 and hybridized with Pei-kuh to construct the isolated population. E6-5 harbored W1944 introgression segment on chromosome 8, but it had not carried SH4 gene and exhibited a very easy seed shattering phenotype. By analyzing an F2 segregation population constructed using E6-5 and Pei-kuh, we narrowed down the SHATTERING8 (SH8, qSHT-8) in the 26.4 kb interval. There were four protein-coding genes in this region. The comparison of PEI-Kuh and E6-5 sequencing revealed that LOC_Os08g41950 contained three single nucleotide polymorphisms (SNPs) in coding region. Meanwhile, qRT-PCR revealed that LOC_Os08g41950 was expressed in the junction of flower and pedicel, where the abscission layer was formed and shed off. We considered LOC_Os08g41950 as the candidate gene for SH8. To verify whether LOC_Os08g41950 was responsible for rice seed shattering, we constructed an overexpression vector using LOC_Os08g41950 encoding sequence from E6-5 and transformed it into Pei-huh. Compared with Pei-kuh, the shattering ability of transgenic plants was significantly enhanced. In addition, consistent with the BTS testing results, transgenic plants had smoother fracture surface of pedicel compared with that of Pei-kuh in scanning electron microscopy photos. These results would facilitate the study of rice domestication and seed shattering regulation mechanism. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
47. SRY is a Key Mediator of Sexual Dimorphism in Hepatic Ischemia/Reperfusion Injury.
- Author
-
Dong, Jian, Ke, Meng-Yun, Wu, Xiao-Ning, Ding, Hong-Fan, Zhang, Li-Na, Ma, Feng, Liu, Xue-Min, Wang, Bo, Liu, Jian-Lin, Lu, Shao-Ying, Wu, Rongqian, Pawlik, Timothy M., Lyu, Yi, and Zhang, Xu-Feng
- Abstract
Objectives: To identify the role and mechanism of a male specific gene, SRY, in I/R-induced hepatic injury. Background: Males are more vulnerable to I/R injury than females. However, the mechanism of these sex-based differences remains poorly defined. Methods: Clinicopathologic data of patients who underwent hepatic resection were identified from an international multi-institutional database. Liver specific SRY TG mice were generated, and subjected to I/R insult with their littermate WT controls in vivo. In vitro experiments were performed by treating primary hepatocytes from TG and WT mice with hypoxia/reoxygen-ation stimulation. Results: Clinical data showed that postoperative aminotransferase level, incidence of overall morbidity and liver failure were markedly higher among 1267 male versus 508 female patients who underwent hepatic resection. SRY was dramatically upregulated during hepatic I/R injury. Overexpression of SRY in male TG mice and ectopic expression of SRY in female TG mice exacerbated liver I/R injury compared with WTs as manifested by increased inflammatory reaction, oxidative stress and cell death in vivo and in vitro. Mechanistically, SRY interacts with Glycogen synthase kinase-3β (GSK-3β) and β-catenin, and promotes phosphorylation and degradation of β-catenin, leading to suppression of the downstream FOXOs, and activation of NF-κBand TLR4 signaling. Furthermore, activation of β-catenin almost completely reversed the SRYoverexpression-mediated exacerbation of hepatic I/R damage. Conclusions: SRY is a novel hepatic I/R mediator that promotes hepatic inflammatory reaction, oxidative stress and cell necrosis via inhibiting Wnt/β-catenin signaling, which accounts for the sex-based disparity in hepatic I/R injuries. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
48. Integral imaging near-eye 3D display using a nanoimprint metalens array
- Author
-
Fan, Zhi-Bin, Cheng, Yun-Fan, Chen, Ze-Ming, Liu, Xia, Lu, Wen-Long, Li, Shi-Hao, Jiang, Shao-Ji, Qin, Zong, and Dong, Jian-Wen
- Abstract
Integral imaging (II) display, one of the most critical true-3D display technologies, has received increasing research recently. Significantly, an achromatic metalens array has realized a broadband metalens-array-based II (meta-II). However, the past micro-scale metalens arrays were incompatible with commercial micro-displays; furthermore, the elemental image array (EIA) rendering is always slow. The two hinders in device and algorithm prevent meta-II from being used for practical video-rate near-eye displays (NEDs). This research demonstrates a meta-II NED combining a commercial micro-display and a metalens array. The large-area nanoimprint technology fabricates the metalens array, and a novel real-time rendering algorithm is proposed to generate the EIA. The hardware and software efforts solve the bottlenecks of video-rate meta-II displays. We also build a see-through prototype based on our meta-II NED, demonstrating the feasibility of augmented reality. Our work explores the potential of video-rate meta-II displays, which we expect can be valuable for future virtual and augmented reality.
- Published
- 2024
- Full Text
- View/download PDF
49. Injectable Nanorobot-Hydrogel Superstructure for Hemostasis and Anticancer Therapy of Spinal Metastasis
- Author
-
Chen, Qing, Yan, Miao, Hu, Annan, Liang, Bing, Lu, Hongwei, Zhou, Lei, Ma, Yiqun, Jia, Chao, Su, Dihan, Kong, Biao, Hong, Wei, Jiang, Libo, and Dong, Jian
- Abstract
Site-selective superassembly was used to synthesize a nanorobot with bionic rod-shaped head/hollow tail structure, exhibiting strong photothermal effect, high drug loading capacity, precise and controlled drug release, and excellent motility.Injectable regenerated silk fibroin (RSF) nanofibril hydrogels were developed via simple sonication, offering significant production, structural, and performance advantages.Nanorobot/thrombin (Thr)/RSF nanofibril hydrogels reduced intraoperative bleeding of hepatocellular carcinoma (HCC) spinal metastasis, provided starvation embolization, and prevented post-surgery recurrence.Nanorobot/Thr/RSF nanofibril hydrogels inhibited blood supply to residual tumors and reduced neovascularization, inhibiting post-surgery HCC spinal metastasis recurrence.
- Published
- 2024
- Full Text
- View/download PDF
50. Effect of ambient temperature on the jet characteristics of a swirl oxygen lance with mixed injection of CO2+ O2
- Author
-
Feng, Chao, Dong, Kai, Zhu, Rong, Lin, Tao, Dong, Jian-feng, Xia, Tao, and Ren, Xin
- Abstract
O2mixed with CO2gas has been successfully applied in converter smelting; however, up to now, there have been few studies regarding the jet characteristics of the mixed injection of the swirl oxygen lance nozzle and the influence of different ambient temperature conditions on jet characteristics compared with common nozzles. In this study, Fluent software was used to simulate the jet characteristics of a four-hole common nozzle and a four-hole swirl nozzle under four different ambient temperature conditions to inject 95% O2+ 5% CO2and analyze the influence of different ambient temperatures on nozzle-jet characteristics. The results show that with an increase in the ambient temperature, the jet-axis velocity and nozzle centerline speed increase. Under the same distance condition, the distance between the maximum radial velocity point of the jet and the centerline of the nozzle becomes larger, with a velocity greater than that of the swirl nozzle. However, the influence of the ambient temperature on the offset of the jet centerline is small. With an increase in the ambient temperature and distance, the jet-axis temperature increases and the temperature of the nozzle centerline decreases. The research results can provide a theoretical reference for the optimal design of a CO2+ O2swirl oxygen lance nozzle.
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.