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L’objectif de cette étude était d’évaluer en vie réelle l’impact de l’antécédent de tumeur de vessie n’infiltrant pas le muscle (TVNIM) sur l’efficacité de la chimiothérapie néoadjuvante (CNA) chez les patients traités par cystectomie totale (CT) pour une tumeur de vessie infiltrant le muscle (TVIM).

La sténose d’anastomose urétro-vésicale dans les suites d’une prostatectomie radicale est une complication rare. Elle toucherait moins de 5 % des patients. Les traitements endoscopiques font partie de la prise en charge de première ligne. Cependant, certains patients récidivent après urétrotomies, justifiant une prise en charge radicale. Notre objectif est de décrire cette intervention et de montrer sa faisabilité.

The influence of chlorpromazine (CPZ) on cerebral turnover of catecholamines has been well established (1-3). Evidence that a specific increase in tyrosine–dopamine transfer is caused by the drug has also been reported (4, 5). Recently a protein–chlorpromazine complex has been demonstrated and an effect of the CPZ-free radicals on ATPase has been shown (6, 7). Previous studies have indicated that CPZ inhibits brain mitochondrial oxidative phosphorylation, acting as an uncoupler (8) and inhibiting oxidation of tricarboxylic acid cycle substrate (9). The drug inhibits orotic acid incorporation into nucleic acids in Bacillus megaterium, but it does not affect incorporation of adenine or thymidine. The present study deals with the effect of CPZ on in vivoRNA synthesis in rat brain.Materials and Methods.Male, Charles River rats, weighing 200-300 g were used. Plastic cannulas (Yeda, Rehovot, Israel. Cat. No. 92-103) were implanted 2.5 mm lateral and 2.0 mm posterior to the bregma. The rats were paired at random into controls and experimental animals. Seven days after cannulation, 2 mg CPZ in 0.5 ml were injected ip twice a day during 10 days. Control rats were also injected ip with the same volume of saline. The rats were kept at 20-25° and fed ad libitum.After CPZ treatment the animals were superficially anesthetized with ether and 50 μCi of 3H-uridine (15 Ci/mmole, Israel Nuclear Research Center) in 5 μl saline were injected with an 11 mm needle into the lateral ventricle through the cannula with a microsy-ringe.Eighteen hours later the rats were decapitated. The brain was homogenized in TMKB buffer (Tris–HCl buffer 0.05 M(pH 7.8), 0.01 MMgAc; 0.5 MKCl Bentonite 2%). All manipulations were done at 4°. The amount of radioactive precursor in the brain was quantitated by counting 0.1 ml of each brain homogenate as described below.

La sténose d’anastomose urétro-vésicale dans les suites d’une prostatectomie totale est une complication rare. Elle toucherait entre 1 et 5 % des patients. Les traitements endoscopiques font partie de la prise en charge de première ligne. Cependant, certains patients récidivent après urétrotomies, justifiant une prise en charge radicale.

La majorité des tumeurs de la vessie diagnostiquées n’infiltrent pas le muscle dans la pratique. En cas de TVNIM à très haut risque une cystectomie est parfois proposée d’emblée ou notamment en cas d’échec du traitement d’induction par BCG-thérapie. Le but de notre étude était de rapporter les résultats carcinologiques en cas de TVNIM opérés d’une cystectomie radicale d’emblée ou immédiatement après BCG.

Experiments indicate that the adrenal gland is necessary for the enhancing effects on weight gain, efficiency of food utilization, maze learning ability and resistance to thiourea toxicity previously shown to result from handling, in the intact young albino rat.