1. Association of subungual melanoma and subungual squamous cell carcinoma: A case series.
- Author
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Boespflug, Amélie, Debarbieux, Sébastien, Depaepe, Lauriane, Chouvet, Brigitte, Maucort-Boulch, Delphine, Dalle, Stéphane, Balme, Brigitte, and Thomas, Luc
- Abstract
Background: Subungual squamous cell carcinoma (SSCC) and subungual melanoma (SUM) are rare tumors. Several case reports of association of SSCC with SUM (SSCC-SUM) have been published.Objective: We sought to document the clinical, dermoscopic, and histologic features in a case series of SSCC-SUMs and describe their relative frequency compared with those of SSCC and SUM.Methods: All patients who underwent surgical exploration of the nail apparatus with a dermatopathologic examination from 2012 to 2015 were reviewed retrospectively to identify all cases of SSCC, SUM, and SSCC-SUM. For patients with SSCC-SUM, clinical characteristics were obtained from electronic medical records. All histologic specimens were reviewed by 3 dermatopathologists.Results: The medical records of 456 patients were reviewed. SSCC was diagnosed in 78 (17%), SUM was diagnosed in 63 (14%), and SSCC-SUM was diagnosed in 9. Patients with SSCC-SUM accounted for 11% of those with a diagnosis of SSCC (9 of 78) and 14% of those with a diagnosis of SUM (9 of 63).Limitations: This was a single-institution retrospective study.Conclusion: The association of SSCC and SUM is relatively frequent in patients with SUM and warrants further consideration to understand the underlying mechanisms involved. [ABSTRACT FROM AUTHOR]- Published
- 2018
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