824 results on '"Dagher, A."'
Search Results
2. Robotic Versus Laparoscopic Liver Resection in Various Settings
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Sijberden, Jasper P., Hoogteijling, Tijs J., Aghayan, Davit, Ratti, Francesca, Tan, Ek-Khoon, Morrison-Jones, Victoria, Lanari, Jacopo, Haentjens, Louis, Wei, Kongyuan, Tzedakis, Stylianos, Martinie, John, Osei Bordom, Daniel, Zimmitti, Giuseppe, Crespo, Kaitlyn, Magistri, Paolo, Russolillo, Nadia, Conci, Simone, Görgec, Burak, Benedetti Cacciaguerra, Andrea, D’Souza, Daniel, Zozaya, Gabriel, Caula, Cèlia, Geller, David, Robles Campos, Ricardo, Croner, Roland, Rehman, Shafiq, Jovine, Elio, Efanov, Mikhail, Alseidi, Adnan, Memeo, Riccardo, Dagher, Ibrahim, Giuliante, Felice, Sparrelid, Ernesto, Ahmad, Jawad, Gallagher, Tom, Schmelzle, Moritz, Swijnenburg, Rutger-Jan, Fretland, Åsmund Avdem, Cipriani, Federica, Koh, Ye-Xin, White, Steven, Lopez Ben, Santi, Rotellar, Fernando, Serrano, Pablo E., Vivarelli, Marco, Ruzzenente, Andrea, Ferrero, Alessandro, Di Benedetto, Fabrizio, Besselink, Marc G., Sucandy, Iswanto, Sutcliffe, Robert P., Vrochides, Dionisios, Fuks, David, Liu, Rong, D’Hondt, Mathieu, Cillo, Umberto, Primrose, John N., Goh, Brian K.P., Aldrighetti, Luca A., Edwin, Bjørn, and Abu Hilal, Mohammad
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- 2024
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3. Economic policy uncertainty: Global energy security with diversification.
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Dagar, Vishal, Dagher, Leila, Rao, Amar, Doytch, Nadia, and Kagzi, Muneza
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ECONOMIC uncertainty ,ENERGY security ,ECONOMIC policy ,CLEAN energy ,QUANTILE regression ,CARBON paper - Abstract
Global energy security is a growing worldwide concern in the presence of high economic policy uncertainty (EPU) that can be addressed by advancing sustainable energy diversification (ED) practices. Energy security can be estimated by combining ED and EPU indices; hence, this study uses a dataset covering three continents and 26 countries from 1995 to 2023 to measure energy security employing this approach. The study employs quantile regression and panel data analysis, finding a positive relationship between EPU and ED. The results reveal that when EPU increases, the spectrum of energy sources declines, negatively impacting energy security. Other factors of globalization, Gross Domestic Product, gross capital formation, and the labor force also have an impact on the spectrum of energy sources. To obtain a sustainable level of ED, policymakers should increase investment in gross capital formation because economic growth and openness via pro-global policies have less impact on ED. This study also demonstrates that labor capital shifts have a significant effect on ED. The quantitative results reveal the importance of clear and precise economic policies for increasing investment in carbon-free energy security. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2024
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4. Incidence of ocular surface squamous neoplasia in pterygium specimens.
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Yang, Yelin, Bachour, Kenan, Tong, Maya, Khair, Diana, Gaffar, Judy, Robert, Marie-Claude, Thompson, Paul, Racine, Louis, Segal, Laura, and Harissi-Dagher, Mona
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Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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5. Latest development on Sub-10μm technologies at LYNRED
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Fulop, Gabor F., MacDougal, Michael H., Ting, David Z., Kimata, Masafumi, Rubaldo, Laurent, Morisset, Nicolas, Brunner, Alexandre, Grezes, Cécile, Péré-Laperne, Nicolas, Dagher, Gulnar, Blay, Alexandra, Kerlain, Alexandre, Lobre, Clement, Gravrand, Olivier, Jenouvrier, Pierre, and Billon-Lanfrey, David
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- 2024
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6. The Incidence of Postoperative Complications Following Lumbar and Bone Marrow Punctures in Pediatric Anesthesia: Insights From APRICOT
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Dagher, Krystelle, Benvenuti, Claudia, Virag, Kathy, and Habre, Walid
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- 2024
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7. Validation of the Ankle Ligament Reconstruction-Return to Sports after Injury (ALR-RSI) Score as a Tool to Assess Psychological Readiness to Return to Sport in an Active Population After Ankle Fracture Surgery: A Cross-sectional Study.
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Saliba, Ibrahim, Cannell, Stuart, Valentin, Eugenie, Dagher, Tanios, Bauer, Thomas, Anract, Philippe, Feruglio, Sylvain, Vialle, Raphael, Moussellard, Hugues Pascal, and Hardy, Alexandre
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Ankle injuries account for 15% to 25% of all sports injuries resulting in significant pain and loss of function. The purpose of this cross-sectional study was to validate a scale to help surgeons quantify the psychological readiness to Return To Sport (RTS) in patients undergoing ankle fracture surgery. ALR-RSI was used to assess the psychological readiness for RTS in athletic patients who underwent ankle fracture fixation between January 2020 and January 2021. Participants filled out ALR-RSI and 2 Patient-Related Outcome Measurement (PROM) tools: Olerud-Molander Ankle Score (OMAS) and Self-Reported Foot and Ankle Score (SEFAS). A total of 93 patients were included. There was a strong correlation between ALR-RSI and both OMAS and SEFAS, with Pearson coefficients of r = 0.58 and 0.53, respectively. ALR-RSI was significantly higher in the RTS group than in those who no longer practiced their main preinjury sport. Moreover, the discriminant validity of ALR-RSI (AUC = 0.81) was better than that of the SEFAS and OMAS (AUC = 0.64 and 0.65, respectively, p =.001). The intra-class correlation coefficient ρ of 0.94 showed excellent reproducibility. At an optimal cutoff value of 76.7, ALR-RSI had a sensitivity of 81% and a specificity of 75% with a Youden index of 0.56. In conclusion, ALR-RSI was a valid and reproducible tool to evaluate the psychological readiness for RTS in an active population after an ankle fracture. This score could help surgeons identify athletes who may have unfavorable postoperative outcomes and provide support on the ability to RTS. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Adapting semi-analytical treatments to the time-fractional derivative Gardner and Cahn-Hilliard equations.
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Hassan, A., Arafa, A.A.M., Rida, S.Z., Dagher, M.A., and El Sherbiny, H.M.
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POWER series ,LEAST squares ,EQUATIONS - Abstract
This paper used the flexible and efficient least squares residual power series method (LSRPSM) to solve the time-fractional derivative Cahn-Hilliard and Gardener equations. The LSRPSM combines the residual power series method (RPSM) and the least squares method. These calculations were found based on Caputo's sense and the fractional Wronskian concept. Approximate solutions are found more accurately, faster, and with fewer expansion terms than the classical (RPS) method. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Human iPSC-Based Model of COPD to Investigate Disease Mechanisms, Predict SARS-COV-2 Outcome, and Test Preventive Immunotherapy
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Dagher, Rania, Moldobaeva, Aigul, Gubbins, Elise, Clark, Sydney, Madel Alfajaro, Mia, Wilen, Craig B, Hawkins, Finn, Qu, Xiaotao, Chien Chiang, Chia, Li, Yang, Clarke, Lori, Ikeda, Yasuhiro, Brown, Charles, Kolbeck, Roland, Ma, Qin, Rojas, Mauricio, Koff, Jonathan L, and Ghaedi, Mahboobe
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Chronic inflammation and dysregulated repair mechanisms after epithelial damage have been implicated in chronic obstructive pulmonary disease (COPD). However, the lack of ex vivo-models that accurately reflect multicellular lung tissue hinders our understanding of epithelial-mesenchymal interactions in COPD. Through a combination of transcriptomic and proteomic approaches applied to a sophisticated in vitro iPSC-alveolosphere with fibroblasts model, epithelial-mesenchymal crosstalk was explored in COPD and following SARS-CoV-2 infection. These experiments profiled dynamic changes at single-cell level of the SARS-CoV-2-infected alveolar niche that unveiled the complexity of aberrant inflammatory responses, mitochondrial dysfunction, and cell death in COPD, which provides deeper insights into the accentuated tissue damage/inflammation/remodeling observed in patients with SARS-CoV-2 infection. Importantly, this 3D system allowed for the evaluation of ACE2-neutralizing antibodies and confirmed the potency of this therapy to prevent SARS-CoV-2 infection in the alveolar niche. Thus, iPSC-alveolosphere cultured with fibroblasts provides a promising model to investigate disease-specific mechanisms and to develop novel therapeutics.Graphical Abstract
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- 2024
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10. International Society of Urological Pathology Consensus Conference on Current Issues in Bladder Cancer. Working Group 4
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Warrick, Joshua I., Al-Ahmadie, Hikmat, Berman, David M., Black, Peter C., Flaig, Thomas W., Höglund, Mattias, Bubendorf, Lukas, van der Kwast, Theodorus H., Cheng, Liang, Adeniran, Adebowale, Al-Ahimadie, Hikmat, Algaba, Fernando, Allory, Yves, Bhattarai, Selina, Black, Peter, Berman, David, Bertz, Simone, Bubendorf, Lukas, Carlsen, Birgitte, Carvalho, Rita, Cheng, Liang, Chijioke, Obinna, Cho, Yong Mee, Comperat, Eva, di Cunha, Isabela, Dagher, Julien, de Cunha, Isabella, Delahunt, Brett, Downes, Michelle, Flaig, Thomas, Fleischmann, Achim, Florescu, Cosmin, Fontugne, Jacqueline, Genitsch, Vera, Gløersen, Guro Horni, von Gunten, Michael, Grobholz, Rainer, HanselArndt Hartmann, Donna, Hernandez, Loren Herrera, Hogland, Mattias, Huang, Jiaoti, Jensen, Brad, Iczkowski, Kenneth, Jimenez, Rafael, Jovanovic, Bojana, Kamat, Ashish, Koellermann, Jens, Levin, Trevor, Liedberg, Fredrik, Lopez-Beltran, Antonio, Loya, Anand C, Lyngra, Marianne, McHale, Teresa, Mokeddem, Khadidja, Netto, George, Nourieh, Maya, O’Rourke, Declan, Ostahi, Irina-Alexandra, Paner, Gladell, Picken, Maria M, Pineda, Flavia Guzman, Raspollini, Camelia Radulescu Maria, Reis, Henning, Ruoyu, Shi, Samaratunga, Hemamali, Semba, Remi, Shah, Nigam, Shen, Steven, Smith, Steven, Smith, Tovia, Srigley, John, Suzigan, Sueli, Swarbrick, Nicole, Szalay, Ildiko, Talleraas, Inger, Tille, Jean-Christophe, Toma, Marieta, Trias, Isabel, Tsuzuki, Toyonori, van der Kwast, Theodorus, van Rhijn, Bas, Varma, Murali, Verbeke, Sofie, Verma, Sangeeta, Vlajnic, Tatjana, Vlatkovic, Ljiljana, Warren, Anne, Warrick, Joshua, Williamson, Sean, Wobker, Sara, Woods, Clifton, Yang, Chen, and Yoon, Ghilsuk
- Abstract
Molecular subtyping has been a major focus of bladder cancer research over the past decade. Despite many promising associations with clinical outcomes and treatment response, its clinical impact has yet to be defined. As part of the 2022 International Society of Urological Pathology Conference on Bladder Cancer, we reviewed the current state of the science for bladder cancer molecular subtyping. Our review included several different subtyping systems. We derived the following 7 principles, which summarize progress and challenges of molecular subtyping: (1) bladder cancer has 3 major molecular subtypes: luminal, basal-squamous, and neuroendocrine; (2) signatures of the tumor microenvironment differ greatly among bladder cancers, particularly among luminal tumors; (3) luminal bladder cancers are biologically diverse, and much of this diversity results from differences in features unrelated to the tumor microenvironment, such as FGFR3 signaling and RB1 inactivation; (4) molecular subtype of bladder cancer associates with tumor stage and histomorphology; (5) many subtyping systems include idiosyncrasies, such as subtypes recognized by no other system; (6) there are broad fuzzy borders between molecular subtypes, and cases that fall on these fuzzy borders are often classified differently by different subtyping systems; and (7) when there are histomorphologically distinct regions within a single tumor, the molecular subtypes of these regions are often discordant. We reviewed several use cases for molecular subtyping, highlighting their promise as clinical biomarkers. Finally, we conclude that data are currently insufficient to support the routine use of molecular subtyping to guide bladder cancer management, an opinion shared with the majority of conference attendees. We also conclude that molecular subtype should not be considered an “intrinsic” property of a tumor but should instead be considered the result of a specific laboratory test, performed using a specific testing platform and classification algorithm, validated for a specific clinical application.
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- 2024
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11. International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2
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Paner, Gladell P., Kamat, Ashish, Netto, George J., Samaratunga, Hemamali, Varma, Murali, Bubendorf, Lukas, van der Kwast, Theodorus H., Cheng, Liang, Adeniran, Adebowale, Al-Ahimadie, Hikmat, Algaba, Fernando, Bhattarai, Yves Allory Selina, Black, Peter, Berman, David, Bertz, Simone, Bubendorf, Lukas, Carlsen, Birgitte, Carvalho, Rita, Cheng, Liang, Chijioke, Obinna, Cho, Yong Mee, Comperat, Eva, di Cunha, Isabela, Dagher, Julien, de Cunha, Isabella, Delahunt, Brett, Downes, Michelle, Flaig, Thomas, Fleischmann, Achim, Florescu, Cosmin, Fontugne, Jacqueline, Genitsch, Vera, Gløersen, Guro Horni, von Gunten, Michael, Grobholz, Rainer, Hansel, Donna, Hartmann, Arndt, Hernandez, Loren Herrera, Hogland, Mattias, Huang, Jiaoti, Jensen, Brad, Iczkowski, Kenneth, Jimenez, Rafael, Jovanovic, Bojana, Kamat, Ashish, Koellermann, Jens, Levin, Trevor, Liedberg, Fredrik, Lopez-Beltran, Antonio, Loya, Anand C, Lyngra, Marianne, McHale, Teresa, Mokeddem, Khadidja, Netto, George, Nourieh, Maya, O’Rourke, Declan, Ostahi, Irina-Alexandra, Paner, Gladell, Picken, Maria M, Pineda, Flavia Guzman, Raspollini, Camelia Radulescu Maria, Reis, Henning, Ruoyu, Shi, Samaratunga, Hemamali, Semba, Remi, Shah, Nigam, Shen, Steven, Smith, Steven, Smith, Tovia, Srigley, John, Suzigan, Sueli, Swarbrick, Nicole, Szalay, Ildiko, Talleraas, Inger, Tille, Jean-Christophe, Toma, Marieta, Trias, Isabel, Tsuzuki, Toyonori, van der Kwast, Theodorus, van Rhijn, Bas, Varma, Murali, Verbeke, Sofie, Verma, Sangeeta, Vlajnic, Tatjana, Vlatkovic, Ljiljana, Warren, Anne, Warrick, Joshua, Williamson, Sean, Wobker, Sara, Woods, Clifton, Yang, Chen, and Yoon, Ghilsuk
- Abstract
The 2022 International Society of Urological Pathology (ISUP) Consensus Conference on Urinary Bladder Cancer Working Group 2 was tasked to provide evidence-based proposals on the applications of grading in noninvasive urothelial carcinoma with mixed grades, invasive urothelial carcinoma including subtypes (variants) and divergent differentiations, and in pure non-urothelial carcinomas. Studies suggested that predominantly low-grade noninvasive papillary urothelial carcinoma with focal high-grade component has intermediate outcome between low- and high-grade tumors. However, no consensus was reached on how to define a focal high-grade component. By 2004 WHO grading, the vast majority of lamina propria-invasive (T1) urothelial carcinomas are high-grade, and the rare invasive low-grade tumors show only limited superficial invasion. While by 1973 WHO grading, the vast majority of T1 urothelial carcinomas are G2 and G3 and show significant differences in outcome based on tumor grade. No consensus was reached if T1 tumors should be graded either by the 2004 WHO system or by the 1973 WHO system. Because of the concern for underdiagnosis and underreporting with potential undertreatment, participants unanimously recommended that the presence of urothelial carcinoma subtypes and divergent differentiations should be reported. There was consensus that the extent of these subtypes and divergent differentiations should also be documented in biopsy, transurethral resection, and cystectomy specimens. Any distinct subtype and divergent differentiation should be diagnosed without a threshold cutoff, and each type should be enumerated in tumors with combined morphologies. The participants agreed that all subtypes and divergent differentiations should be considered high-grade according to the 2004 WHO grading system. However, participants strongly acknowledged that subtypes and divergent differentiations should not be considered as a homogenous group in terms of behavior. Thus, future studies should focus on individual subtypes and divergent differentiations rather than lumping these different entities into a single clinicopathological group. Likewise, clinical recommendations should pay attention to the potential heterogeneity of subtypes and divergent differentiations in terms of behavior and response to therapy. There was consensus that invasive pure squamous cell carcinoma and pure adenocarcinoma of the bladder should be graded according to the degree of differentiation. In conclusion, this summary of the International Society of Urological Pathology Working Group 2 proceedings addresses some of the issues on grading beyond its traditional application, including for papillary urothelial carcinomas with mixed grades and with invasive components. Reporting of subtypes and divergent differentiation is also addressed in detail, acknowledging their role in risk stratification. This report could serve as a guide for best practices and may advise future research and proposals on the prognostication of these tumors.
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- 2024
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12. The self-focusing of hollow gaussian laser beam in magnetized plasma with transverse magnetic field by operating relativistic nonlinearity
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Hassan, Ameer Ali, Dagher, Abdul Kareem H., and Hassan, Munther B.
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This article presents a theoretical study of the self-focusing process of a hollow Gaussian laser beam (HGLB) inside a plasma medium placed in a magnetic field perpendicular to the direction of the hollow Gaussian laser beam propagation. The self-focusing was studied using relativistic nonlinearity. Particular mathematical equations were derived that describe the nonlinear behavior of hollow Gaussian laser beam when they propagate inside the plasma, and they were solved. This behavior was simulated using the MATLAB program. This study dealt with the effect of order and initial intensity of hollow Gaussian laser beam on the self-focusing process and the impact of the applied magnetic field and plasma density on the self-focusing process.
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- 2024
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13. Survey: Preferred practice patterns in the diagnosis of mucous membrane pemphigoid amongst cornea specialists
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Moussa, Sarah, Tong, Maya, Robert, Marie-Claude, Harissi-Dagher, Mona, Ahmad, Sajjad, and Jabbour, Samir
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Purpose To evaluate preferred diagnostic tools and treatment decision-making factors in cases suspicious of mucous membrane pemphigoid (MMP) amongst ophthalmologists and cornea specialists.Methods Web-based survey, consisting of 14 multiple choice questions, posted to the Cornea Society Listserv Keranet, the Canadian Ophthalmological Society Cornea Listserv, and the Bowman Club Listserv.Results One hundred and thirty-eight ophthalmologists participated in the survey. Eighty-six percent (86%) of respondents were cornea trained and practiced in either North America or Europe (83%). Most respondents (72%) routinely perform conjunctival biopsies for all suspicious cases of MMP. For those who do not, fear that biopsy will exacerbate inflammation was the most common reason to defer investigation (47%). Seventy-one percent (71%) performed biopsies from perilesional sites. Ninety-seven percent (97%) ask for direct (DIF) studies and 60% for histopathology in formalin. Most do not recommend biopsy at other non-ocular sites (75%), nor do they perform indirect immunofluorescence for serum autoantibodies (68%). Immune-modulatory therapy is started following positive biopsy results for most (66%), albeit most (62%) would not let a negative DIF influence the choice of starting treatment should there be clinical suspicion of MMP. Differences in practice patterns as they relate to level of experience and geographical location are contrasted to the most up-to-date available guidelines.Conclusion Responses to the survey suggest that there is heterogeneity in certain practice patterns for MMP. Biopsy remains an area of controversy in dictating treatment plans. Identified areas of need should be targeted in future research.
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- 2024
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14. PGE2inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function
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Morotti, Matteo, Grimm, Alizee J., Hope, Helen Carrasco, Arnaud, Marion, Desbuisson, Mathieu, Rayroux, Nicolas, Barras, David, Masid, Maria, Murgues, Baptiste, Chap, Bovannak S., Ongaro, Marco, Rota, Ioanna A., Ronet, Catherine, Minasyan, Aspram, Chiffelle, Johanna, Lacher, Sebastian B., Bobisse, Sara, Murgues, Clément, Ghisoni, Eleonora, Ouchen, Khaoula, Bou Mjahed, Ribal, Benedetti, Fabrizio, Abdellaoui, Naoill, Turrini, Riccardo, Gannon, Philippe O., Zaman, Khalil, Mathevet, Patrice, Lelievre, Loic, Crespo, Isaac, Conrad, Marcus, Verdeil, Gregory, Kandalaft, Lana E., Dagher, Julien, Corria-Osorio, Jesus, Doucey, Marie-Agnes, Ho, Ping-Chih, Harari, Alexandre, Vannini, Nicola, Böttcher, Jan P., Dangaj Laniti, Denarda, and Coukos, George
- Abstract
Expansion of antigen-experienced CD8+T cells is critical for the success of tumour-infiltrating lymphocyte (TIL)-adoptive cell therapy (ACT) in patients with cancer1. Interleukin-2 (IL-2) acts as a key regulator of CD8+cytotoxic T lymphocyte functions by promoting expansion and cytotoxic capability2,3. Therefore, it is essential to comprehend mechanistic barriers to IL-2 sensing in the tumour microenvironment to implement strategies to reinvigorate IL-2 responsiveness and T cell antitumour responses. Here we report that prostaglandin E2 (PGE2), a known negative regulator of immune response in the tumour microenvironment4,5, is present at high concentrations in tumour tissue from patients and leads to impaired IL-2 sensing in human CD8+TILs via the PGE2receptors EP2 and EP4. Mechanistically, PGE2inhibits IL-2 sensing in TILs by downregulating the IL-2Rγcchain, resulting in defective assembly of IL-2Rβ–IL2Rγcmembrane dimers. This results in impaired IL-2–mTOR adaptation and PGC1α transcriptional repression, causing oxidative stress and ferroptotic cell death in tumour-reactive TILs. Inhibition of PGE2signalling to EP2 and EP4 during TIL expansion for ACT resulted in increased IL-2 sensing, leading to enhanced proliferation of tumour-reactive TILs and enhanced tumour control once the cells were transferred in vivo. Our study reveals fundamental features that underlie impairment of human TILs mediated by PGE2in the tumour microenvironment. These findings have therapeutic implications for cancer immunotherapy and cell therapy, and enable the development of targeted strategies to enhance IL-2 sensing and amplify the IL-2 response in TILs, thereby promoting the expansion of effector T cells with enhanced therapeutic potential.
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- 2024
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15. A review on the use of extracellular vesicles for the delivery of drugs and biological therapeutics
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Amina, Sundus Jabeen, Azam, Tasmia, Dagher, Fatima, and Guo, Bin
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ABSTRACTIntroductionExosomes, a type of extracellular vesicles, are effective tools for delivering small-molecule drugs and biological therapeutics into cells and tissues. Surface modifications with targeting ligands ensure precise delivery to specific cells, minimizing accumulation in healthy organs and reducing the side effects. This is a rapidly growing area in drug delivery research and this review aims to comprehensively discuss the recent advances in the field.Area coveredRecent studies have presented compelling evidence supporting the application of exosomes as efficient delivery vehicles that escape endosome trapping, achieving effective in vivo delivery in animal models. This review provides a systemic discussion on the exosome-based delivery technology, with topics covering exosome purification, surface modification, and targeted delivery of various cargos ranging from siRNAs, miRNAs, and proteins, to small molecule drugs.Expert opinionExosome-based gene and drug delivery has low toxicity and low immunogenicity. Surface modifications of the exosomes can effectively avoid endosome trapping and increase delivery efficiency. This exciting technology can be applied to improve the treatments for a wide variety of diseases.
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- 2024
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16. Safety of same-day discharge after lead extraction procedures.
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Dagher, Lilas, Tfaily, Mohamad Ali, Vavuranakis, Michael, Bhatia, Neal Kumar, Westerman, Stacy B., Shah, Anand D., Lloyd, Michael S., Leal, Miguel, De Lurgio, David B., Merchant, Alam, Panagopoulos, Anastasios, Patel, Anshul M., Tompkins, Christine, Leon, Angel R., Merchant, Faisal M., and El-Chami, Mikhael F.
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Same-day discharge (SDD) after cardiovascular procedures is rapidly gaining ground. We sought to evaluate the safety of SDD after transvenous lead extraction (TLE). We performed a retrospective chart review of patients who underwent elective TLE between January 2020 and October 2021 at our institution. The primary outcome was SDD, and major procedural complications and readmissions within 30 days of the procedure were secondary outcomes. In this analysis of 111 patients who underwent elective TLE, 80 patients (72%) were discharged on the same day (SDD group) while 31 patients (28%) stayed overnight (overnight group). Lead malfunction was the most common indication for TLE in both groups. Patients in the overnight group were more likely to have a lead dwell time of ≤10 years than those in the SDD group (38.7% vs 20% of all leads in each group; P =.042), have laser sheaths used for extraction and a higher number of leads extracted. No major complications were reported in both groups. In a multivariate analysis, lower body mass index and the use of laser sheath during TLE were predictors of overnight stay. Patients who underwent a procedure using advanced extraction techniques were 3.5 times more likely to stay overnight (95% confidence interval 1.27–9.78; P =.016). In appropriately selected patients undergoing elective lead extraction, SDD is feasible and safe. Higher body mass index, fewer extracted leads, shorter lead dwell times (<10 years), and less frequent use of laser-powered extraction sheaths were associated with an increased likelihood of SDD. [ABSTRACT FROM AUTHOR]
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- 2023
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17. Using the ACT matrix to improve sleep: A practical guide for implementing the "what" and the "how" of sleep hygiene.
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Leckey, Jennifer M., Dagher, Alexandra, and Lee-Baggley, Dayna L.
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Insufficient sleep duration and quality among adults is a growing public health concern. While cognitive behavioural therapy for insomnia is effective in treating clinical levels of sleep difficulty, intervention for subclinical sleep difficulty has been lacking. The "What" and the "How" of Sleep Hygiene is an Acceptance and Commitment Therapy-based (ACT) psychoeducation group focused on improving sleep hygiene and supporting long term behaviour change. The group involved 8 sessions, each focused on a different aspect of sleep hygiene throughout the day (e.g., morning routine). Three behaviour change principles and the well-established ACT tool, the Matrix, were central to the intervention designed to help implement sleep hygiene. The session summaries are intended to provide clinicians with a practical guide for implementation. • Acceptance and commitment therapy can be used to address sleep hygiene. • The ACT Matrix can be used as a behaviour change tool. • A practical guide to implementing the "what" and the "how" of sleep hygiene. [ABSTRACT FROM AUTHOR]
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- 2023
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18. May Measurement Month 2021: an analysis of blood pressure screening results from Venezuela
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Hernández-Hernández, Rafael, Guzmán-Franulic, Mónica L, Rawik-Dagher, Yuly, Beaney, Thomas, Poulter, Neil R, Duin-Balza, Amanda, Armas-Hernández, María J, Silva, Egle, Morr, Igor, Octavio-Seijas, José Andrés, Toopchiani, Sima, and Armas-Padilla, María C
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Cardiovascular diseases continue to be the main cause of death in Venezuela, and hypertension is the principal risk factor. The May Measurement Month (MMM) campaign is a global initiative aimed to raising awareness of hypertension, which has been conducted in Venezuela since 2017. May Measurement Month 2021 included 46 732 participants with a mean age of 56.4 years (SD 14.4), 57.9% of whom were female. The percentage with hypertension was 60.3% (57.9% of females and 63.7% of males), 82.3% (84.8% of females and 79.2% of males) were aware, and 80.2% were taking antihypertensive medication. Of those on antihypertensive medication, 44.2% (41.2% of females and 48.2% of males) were not controlled [blood pressure (BP) ≥ 140/≥90 mmHg], with 61.3% receiving one drug, 30.0% two drugs, and 8.7% three or more drugs. 87.5% of those on treatment reported taking it regularly. Conditions associated with higher BP levels include fewer years of education, having a previous diagnosis of hypertension, and women who were hypertensive during a previous pregnancy. Physical activity and pregnancy were conditions associated with lower BP levels. A previous positive COVID-19 test was reported in 11.1%, and one or more COVID-19 vaccinations reported in 22.7% of participants. Of those on antihypertensive medication, 78.8% reported their treatment was not affected by COVID-19. Results are consistent with previous MMM campaigns and indicate that the screening campaign is feasible and useful to identify hypertension even in exceptional conditions such as the COVID-19 pandemic.
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- 2024
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19. Forks in the road for CAR T and CAR NK cell cancer therapies
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Dagher, Oula K. and Posey, Avery D.
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The advent of chimeric antigen receptor (CAR) T cell therapy has resulted in unprecedented long-term clearance of relapse/refractory hematological malignancies in both pediatric and adult patients. However, severe toxicities, such as cytokine release syndrome and neurotoxicity, associated with CAR T cells affect therapeutic utility; and treatment efficacies for solid tumors are still not impressive. As a result, engineering strategies that modify other immune cell types, especially natural killer (NK) cells have arisen. Owing to both CAR-dependent and CAR-independent (innate immune-mediated) antitumor killing capacity, major histocompatibility complex-independent cytotoxicity, reduced risk of alloreactivity and lack of major CAR T cell toxicities, CAR NK cells constitute one of the promising next-generation CAR immune cells that are also amenable as ‘off-the-shelf’ therapeutics. In this Review, we compare CAR T and CAR NK cell therapies, with particular focus on immunological synapses, engineering strategies and challenges.
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- 2023
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20. Résultats à long terme de la kératoprothèse de Boston de type I au Canada
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Aoun, T. and Harissi-Dagher, M.
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Évaluer les résultats visuels à long terme de la chirurgie de kératoprothèse de Boston (KPro) de type I et identifier les facteurs de risque d’une perte de vision.
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- 2023
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21. Angiopoietin-Like Proteins: Cardiovascular Biology and Therapeutic Targeting for the Prevention of Cardiovascular Diseases
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Thorin, Eric, Labbé, Pauline, Lambert, Mélanie, Mury, Pauline, Dagher, Olina, Miquel, Géraldine, and Thorin-Trescases, Nathalie
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Despite the best pharmacologic tools available, cardiovascular diseases (CVDs) remain a major cause of morbidity and mortality in developed countries. After 2 decades of research, new therapeutic targets, such as angiopoietin-like proteins (ANGPTLs), are emerging. ANGPTLs belong to a family of 8 members, from ANGPTL1 to ANGPTL8; they have structural homology with angiopoietins and are secreted in the circulation. ANGPTLs display a multitude of physiological and pathologic functions; they contribute to inflammation, angiogenesis, cell death, senescence, hematopoiesis, and play a role in repair, maintenance, and tissue homeostasis. ANGPTLs—particularly the triad ANGPTL3, 4, and 8—have an established role in lipid metabolism through the regulation of triacylglycerol trafficking according to the nutritional status. Some ANGPTLs also contribute to glucose metabolism. Therefore, dysregulation in ANGPTL expression associated with abnormal circulating levels are linked to a plethora of CVD and metabolic disorders including atherosclerosis, heart diseases, diabetes, but also obesity and cancers. Because ANGPTLs bind to different receptors according to the cell type, antagonists are therapeutically inadequate. Recently, direct inhibitors of ANGPTLs, mainly ANGPTL3, have been developed, and specific monoclonal antibodies and antisense oligonucleotides are currently being tested in clinical trials. The aim of the current review is to provide an up-to-date preclinical and clinical overview on the function of the 8 members of the ANGPTL family in the cardiovascular system, their contribution to CVD, and the therapeutic potential of manipulating some of them.
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- 2023
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22. Injury prevention strategies at the 2019 FIFA Women's World Cup display a multifactorial approach and highlight subjective wellness measurements
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Saltzman, Eliana B., Levin, Jay M., Dagher, Anna-Maria B., Messer, Michael, Kimball, Ryan, Lohnes, John, Mandelbaum, Bert R., Williams, Riley J., Amendola, Annuziato, Chiampas, George, and Lau, Brian C.
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To report the injury prevention programs utilised by top-level female footballers competing internationally.
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- 2023
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23. Recording Binding Information Directly into DNA-Encoded Libraries Using Terminal Deoxynucleotidyl Transferase.
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Schneider, Lukas A., Sauter, Basilius, Dagher, Koder, and Gillingham, Dennis
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- 2023
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24. Endoscopy-assisted total pars plana vitrectomy during Boston keratoprosthesis type 1 implantation.
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Geoffrion, Dominique, Mullie, Guillaume A., Arej, Nicolas, Rhéaume, Marc-André, and Harissi-Dagher, Mona
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- 2023
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25. Laparoscopic Roux-en-Y fistulojejunostomy as a salvage procedure in patients with chronic gastric leak after sleeve gastrectomy.
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Lainas, Panagiotis, Triantafyllou, Evangelia, Ben Amor, Virginie, Savvala, Natalia, Gugenheim, Jean, Dagher, Ibrahim, and Amor, Imed Ben
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The most common postoperative complication of laparoscopic sleeve gastrectomy (LSG) is staple-line leak. Even if its rate following LSG has been recently reduced, management of chronic leaks remains challenging. To present a series of patients treated with laparoscopic Roux-en-Y fistulojejunostomy (LRYFJ) for chronic gastric leak (>12 wk) post-LSG. University hospitals; specialized bariatric surgery units. Data were prospectively gathered and retrospectively analyzed. Parameters of interest were patient characteristics, perioperative data, and postoperative outcomes. Hemodynamically unstable patients and/or presentations of signs of severe sepsis were excluded. Surgical technique was standardized. Fourteen patients underwent LRYFJ for chronic gastric leak (12 women, 2 men). The mean age was 49.2 years and the mean weight was 88.7 kg with a mean body mass index of 31.1 kg/m
2 . All procedures were successfully performed by laparoscopy except 1 (7.1%) converted to open surgery. The mean operative time was 198 minutes, with a mean estimated blood loss of 135.7 mL and 2 patients necessitating transfusion (14.2%). Mortality was null. Five postoperative complications were noted (35.7%): 2 leaks of the fistulojejunostomy treated by antibiotherapy and endoscopic drainage; 1 perianastomotic hematoma treated by relaparoscopy and antibiotherapy; and 1 pleural effusion and 1 hematemesis both medically treated. The mean length of hospital stay was 14 days. The mean follow-up was 40 months, with all patients being in good health at last contact. LRYFJ seems to be a good salvage option in selected patients for the treatment of chronic gastric leaks after LSG. However, it is a challenging procedure and should be performed in experienced bariatric centers by expert bariatric surgeons. • Management of chronic gastric staple-line leaks (> 12 weeks) after LSG remains challenging. • Fourteen patients with chronic gastric leak post-LSG were treated with salvage laparoscopic Roux-en-Y fistulojejunostomy (LRYFJ). • LRYFJ seems to be a good surgical option for the treatment of chronic gastric leaks after LSG. • It is a challenging procedure and should be performed in experienced bariatric centers by expert bariatric surgeons. • Careful patient selection is essential since this approach should only be considered in patients with adequate nutritional status and after failure of a well conducted endoscopic management. [ABSTRACT FROM AUTHOR]- Published
- 2023
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26. An International Expert Delphi Consensus on Defining Textbook Outcome in Liver Surgery (TOLS).
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Görgec, Burak, Benedetti Cacciaguerra, Andrea, Pawlik, Timothy M., Aldrighetti, Luca A., Alseidi, Adnan A., Cillo, Umberto, Kokudo, Norihiro, Geller, David A., Wakabayashi, Go, Asbun, Horacio J., Besselink, Marc G., Cherqui, Daniel, Cheung, Tan To, Clavien, Pierre-Alain, Conrad, Claudius, D'Hondt, Mathieu, Dagher, Ibrahim, Dervenis, Christos, Devar, John, and Dixon, Elijah
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Objective: To reach global expert consensus on the definition of TOLS in minimally invasive and open liver resection among renowned international expert liver surgeons using a modified Delphi method. Background: Textbook outcome is a novel composite measure combining the most desirable postoperative outcomes into one single measure and representing the ideal postoperative course. Despite a recently developed international definition of Textbook Outcome in Liver Surgery (TOLS), a standardized and expert consensus-based definition is lacking. Methods: This international, consensus-based, qualitative study used a Delphi process to achieve consensus on the definition of TOLS. The survey comprised 6 surgical domains with a total of 26 questions on individual surgical outcome variables. The process included 4 rounds of online questionnaires. Consensus was achieved when a threshold of at least 80% agreement was reached. The results from the Delphi rounds were used to establish an international definition of TOLS. Results: In total, 44 expert liver surgeons from 22 countries and all 3 major international hepato-pancreato-biliary associations completed round 1. Forty-two (96%), 41 (98%), and 41 (98%) of the experts participated in round 2, 3, and 4, respectively. The TOLS definition derived from the consensus process included the absence of intraoperative grade ≥2 incidents, postoperative bile leakage grade B/C, postoperative liver failure grade B/C, 90-day major postoperative complications, 90-day readmission due to surgery-related major complications, 90-day/in-hospital mortality, and the presence of R0 resection margin. Conclusions: This is the first study providing an international expert consensus-based definition of TOLS for minimally invasive and open liver resections by the use of a formal Delphi consensus approach. TOLS may be useful in assessing patient-level hospital performance and carrying out international comparisons between centers with different clinical practices to further improve patient outcomes. [ABSTRACT FROM AUTHOR]
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- 2023
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27. Success of the Canadian Ophthalmological Society's first virtual meeting amid COVID-19 pandemic.
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Khair, Diana, Chaudhary, Varun, and Harissi-Dagher, Mona
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Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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28. Motor Memory Consolidation Deficits in Parkinson’s Disease: A Systematic Review with Meta-Analysis
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Cristini, Jacopo, Parwanta, Zohra, De las Heras, Bernat, Medina-Rincon, Almudena, Paquette, Caroline, Doyon, Julien, Dagher, Alain, Steib, Simon, and Roig, Marc
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The ability to encode and consolidate motor memories is essential for persons with Parkinson’s disease (PD), who usually experience a progressive loss of motor function. Deficits in memory encoding, usually expressed as poorer rates of skill improvement during motor practice, have been reported in these patients. Whether motor memory consolidation (i.e., motor skill retention) is also impaired is unknown. To determine whether motor memory consolidation is impaired in PD compared to neurologically intact individuals. We conducted a pre-registered systematic review (PROSPERO: CRD42020222433) following PRISMA guidelines that included 46 studies. Meta-analyses revealed that persons with PD have deficits in retaining motor skills (SMD = –0.17; 95% CI = –0.32, –0.02; p = 0.0225). However, these deficits are task-specific, affecting sensory motor (SMD = –0.31; 95% CI –0.47, –0.15; p = 0.0002) and visuomotor adaptation (SMD = –1.55; 95% CI = –2.32, –0.79; p = 0.0001) tasks, but not sequential fine motor (SMD = 0.17; 95% CI = –0.05, 0.39; p = 0.1292) and gross motor tasks (SMD = 0.04; 95% CI = –0.25, 0.33; p = 0.7771). Importantly, deficits became non-significant when augmented feedback during practice was provided, and additional motor practice sessions reduced deficits in sensory motor tasks. Meta-regression analyses confirmed that deficits were independent of performance during encoding, as well as disease duration and severity. Our results align with the neurodegenerative models of PD progression and motor learning frameworks and emphasize the importance of developing targeted interventions to enhance motor memory consolidation in PD.
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- 2023
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29. Closed-form solutions to investigate the nonlinear response of foundations supporting operating machines under blast loads
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Abd-Elhamed, Ayman, Alkhatib, Soliman, and Dagher, Mohamed A
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Machine foundations are subjected to significant dynamic impacts. These impacts could spread to the surrounding regions, affecting workers, sensitive equipment in the same institution, or nearby areas. This study analyzes the response of machine-supporting foundations to harmonic and explosive loads under operational conditions and provides closed-form solutions for predicting responses in terms of displacement, velocity, and acceleration time-histories to two common types of blast loads: a more accurate typical profile and simplified triangular profile. The soil-machine foundation system is regarded as a single-degree-of-freedom (SDOF) system that exhibits elastic–perfectly flexible resistance behavior. For the analysis of the SDOF system, two cases are considered: one assumes that the supporting soil keeps elastic during the explosion, and the peak displacement is less than the elastic one, while the other assumes that the blast occurs in an elastic state, and the peak displacement occurs in a plastic state. By using the closed-form analytical solutions, a detailed parametric analysis is carried out to evaluate the impacts of significant soil-foundation system characteristics such as mass, stiffness, and damping ratio on the response-time history of machine foundations. The findings are compared to those reported in the literature, and relevant conclusions are derived. Obtained results demonstrated that, despite its simplicity and usage of only positive phase to simulate blast loads, the simplified model’s response behavior differs significantly from the typical one. Furthermore, the derived solutions are utilized to design the foundations supporting vibrating machines for both harmonic and blast loads in a variety of conceivable scenarios depending on the blast magnitude.
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- 2023
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30. An atlas of healthy and injured cell states and niches in the human kidney
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Lake, Blue B., Menon, Rajasree, Winfree, Seth, Hu, Qiwen, Melo Ferreira, Ricardo, Kalhor, Kian, Barwinska, Daria, Otto, Edgar A., Ferkowicz, Michael, Diep, Dinh, Plongthongkum, Nongluk, Knoten, Amanda, Urata, Sarah, Mariani, Laura H., Naik, Abhijit S., Eddy, Sean, Zhang, Bo, Wu, Yan, Salamon, Diane, Williams, James C., Wang, Xin, Balderrama, Karol S., Hoover, Paul J., Murray, Evan, Marshall, Jamie L., Noel, Teia, Vijayan, Anitha, Hartman, Austin, Chen, Fei, Waikar, Sushrut S., Rosas, Sylvia E., Wilson, Francis P., Palevsky, Paul M., Kiryluk, Krzysztof, Sedor, John R., Toto, Robert D., Parikh, Chirag R., Kim, Eric H., Satija, Rahul, Greka, Anna, Macosko, Evan Z., Kharchenko, Peter V., Gaut, Joseph P., Hodgin, Jeffrey B., Eadon, Michael T., Dagher, Pierre C., El-Achkar, Tarek M., Zhang, Kun, Kretzler, Matthias, and Jain, Sanjay
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Understanding kidney disease relies on defining the complexity of cell types and states, their associated molecular profiles and interactions within tissue neighbourhoods1. Here we applied multiple single-cell and single-nucleus assays (>400,000 nuclei or cells) and spatial imaging technologies to a broad spectrum of healthy reference kidneys (45 donors) and diseased kidneys (48 patients). This has provided a high-resolution cellular atlas of 51 main cell types, which include rare and previously undescribed cell populations. The multi-omic approach provides detailed transcriptomic profiles, regulatory factors and spatial localizations spanning the entire kidney. We also define 28 cellular states across nephron segments and interstitium that were altered in kidney injury, encompassing cycling, adaptive (successful or maladaptive repair), transitioning and degenerative states. Molecular signatures permitted the localization of these states within injury neighbourhoods using spatial transcriptomics, while large-scale 3D imaging analysis (around 1.2 million neighbourhoods) provided corresponding linkages to active immune responses. These analyses defined biological pathways that are relevant to injury time-course and niches, including signatures underlying epithelial repair that predicted maladaptive states associated with a decline in kidney function. This integrated multimodal spatial cell atlas of healthy and diseased human kidneys represents a comprehensive benchmark of cellular states, neighbourhoods, outcome-associated signatures and publicly available interactive visualizations.
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- 2023
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31. Endoscopy management of sleeve gastrectomy stenosis: what we learned from 202 consecutive patients.
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D'Alessandro, Alessandra, Dumont, Jean-Loup, Dagher, Ibrahim, Zito, Francesco, Galasso, Giovanni, Tranchart, Hadrien, Cereatti, Fabrizio, Catheline, Jean-Marc, Pourcher, Guillaume, Rebibo, Lionel, Calabrese, Daniela, Msika, Simon, Rotkopf, Hugo, Tuszynski, Thierry, Pacini, Filippo, Arienzo, Roberto, D'Alessandro, Antonio, Torcivia, Adriana, Genser, Laurent, and Arapis, Konstantinos
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Gastric sleeve stenosis (GSS) is described in 1%–4% of patients. To evaluate the role of endoscopy in the management of stenosis after laparoscopic sleeve gastrectomy using a standardized approach according to the characteristic of stenosis. Retrospective, observational, single-center study on patients referred from several bariatric surgery departments to an endoscopic referral center. We enrolled 202 patients. All patients underwent endoscopy in a fluoroscopy setting, and a systematic classification of the type, site, and length of the GSS was performed. According to the characteristics of the stenosis, patients underwent pneumatic dilatation or placement of a self-expandable metal stent or a lumen-apposed metal stent. Failure of endoscopic treatment was considered an indication for redo surgery, whereas patients with partial or complete response were followed up for 2 years. In the event of a recurrence, a different endoscopic approach was used. We found inflammatory strictures in 4.5% of patients, pure narrowing in 11%, and functional stenosis in 84.5%. Stenosis was in the upper tract of the stomach in 53 patients, whereas medium and distal stenosis was detected in 138 and 11 patients, respectively, and short stenosis in 194 patients. A total of 126 patients underwent pneumatic dilatation, 8 self-expandable metal stent placement, 64 lumen-apposed metal stent positioning, and 36 combined therapy. The overall rate of endoscopy success was 69%. GSS should be considered to be a chronic disease, and the endoscopic approach seems to be the most successful treatment, with a prolonged positive outcome of 69%. Characteristics of the stenosis should guide the most suitable endoscopic approach. [ABSTRACT FROM AUTHOR]
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- 2023
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32. Global survey on the surgical management of patients affected by colorectal cancer with synchronous liver metastases: impact of surgical specialty and geographic region
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Sijberden, Jasper Paul, Spinelli, Antonino, Ferrero, Alessandro, Chand, Manish, Wexner, Steven, Besselink, Marc G., Dagher, Ibrahim, Zimmitti, Giuseppe, Görgec, Burak, de Lacy, Antonio, Roy, Mayank, Tanis, Pieter, Tonti, Carlo, and Abu Hilal, Mohammed
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Background: Consensus on the best surgical strategy for the management of synchronous colorectal liver metastases (sCRLM) has not been achieved. This study aimed to assess the attitudes of surgeons involved in the treatment of sCRLM. Methods: Surveys designed for colorectal, hepato-pancreato-biliary (HPB), and general surgeons were disseminated through representative societies. Subgroup analyses were performed to compare responses between specialties and continents. Results: Overall, 270 surgeons (57 colorectal, 100 HPB and 113 general surgeons) responded. Specialist surgeons more frequently utilized minimally invasive surgery (MIS) than general surgeons for colon (94.8% vs. 71.7%, p< 0.001), rectal (91.2% vs. 64.6%, p< 0.001), and liver resections (53% vs. 34.5%, p= 0.005). In patients with an asymptomatic primary, the liver-first two-stage approach was preferred in most respondents’ centres (59.3%), while the colorectal-first approach was preferred in Oceania (83.3%) and Asia (63.4%). A substantial proportion of the respondents (72.6%) had personal experience with minimally invasive simultaneous resections, and an expanding role for this procedure was foreseen (92.6%), while more evidence was desired (89.6%). Respondents were more reluctant to combine a hepatectomy with low anterior (76.3%) and abdominoperineal resections (73.3%), compared to right (94.4%) and left hemicolectomies (90.7%). Colorectal surgeons were less inclined to combine right or left hemicolectomies with a major hepatectomy than HPB and general surgeons (right: 22.8% vs. 50% and 44.2%, p= 0.008; left: 14% vs. 34% and 35.4%, p= 0.002, respectively). Conclusion: The clinical practices and viewpoints on the management of sCRLM differ between continents, and between and within surgical specialties. However, there appears to be consensus on a growing role for MIS and a need for evidence-based input. Graphical abstract:
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- 2023
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33. An International Expert Delphi Consensus on Defining Textbook Outcome in Liver Surgery (TOLS)
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Görgec, Burak, Benedetti Cacciaguerra, Andrea, Pawlik, Timothy M., Aldrighetti, Luca A., Alseidi, Adnan A., Cillo, Umberto, Kokudo, Norihiro, Geller, David A., Wakabayashi, Go, Asbun, Horacio J., Besselink, Marc G., Cherqui, Daniel, Cheung, Tan To, Clavien, Pierre-Alain, Conrad, Claudius, D’Hondt, Mathieu, Dagher, Ibrahim, Dervenis, Christos, Devar, John, Dixon, Elijah, Edwin, Bjørn, Efanov, Mikhail, Ettore, Giuseppe M., Ferrero, Alessandro, Fondevilla, Constantino, Fuks, David, Giuliante, Felice, Han, Ho-Seong, Honda, Goro, Imventarza, Oscar, Kooby, David A., Lodge, Peter, Lopez-Ben, Santiago, Machado, Marcel A., Marques, Hugo P., O’Rourke, Nick, Pekolj, Juan, Pinna, Antonio D., Portolani, Nazario, Primrose, John, Rotellar, Fernando, Ruzzenente, Andrea, Schadde, Erik, Siriwardena, Ajith K., Smadi, Sameer, Soubrane, Olivier, Tanabe, Kenneth K., Teh, Catherine S.C., Torzilli, Guido, Van Gulik, Thomas M., Vivarelli, Marco, Wigmore, Stephen J., and Abu Hilal, Mohammad
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- 2023
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34. PO-04-143 A PRAGMATIC SCORE FOR BASELINE ATRIAL FIBROSIS PREVALENCE IN PERSISTENT ATRIAL FIBRILLATION PATIENTS UNDERGOING ABLATION.
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Younes, Hadi, Bidaoui, Ghassan, Mekhael, Mario, Feng, Han, El Hajjar, Abdel Hadi, Chamoun, Nadia, Bsoul, Mayana, Lim, Chanho, Assaf, Ala, Ademi, Besim, Rao, Swati, Mahnkopf, Christian, Donnellan, Eoin, Dagher, Lilas, Pandey, Amitabh C., and Marrouche, Nassir F.
- Published
- 2024
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35. Unveiling ocular surface squamous neoplasia within a conjunctival epithelial inclusion cyst.
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Milad, Daniel, Khellaf, Abdelhakim, Odashiro, Alexandre, and Harissi-Dagher, Mona
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- 2024
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36. Canadians' attitudes toward corneal donation: informational-motivational videos increase willingness toward corneal donation.
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Salimi, Ali, Watt, Harrison, Elhawary, Hassan, Darvish-Zargar, Mahshad, and Harissi-Dagher, Mona
- Abstract
Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
- View/download PDF
37. Risk Factors for Alzheimer Disease Development After Traumatic Brain Injury: A Preliminary Study.
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de Guise, Elaine, Soucy, Beatrice, Joubert, Sven, Correa, José A., and Dagher, Jehane H.
- Abstract
Traumatic brain injury (TBI) is increasingly recognized as a major risk factor for developing neurocognitive disorders, though this association remains controversial. Determination of risk factors for post-traumatic neurodegeneration in patients with TBI is critical given the high incidence of TBI. We hypothesized that cardiovascular and metabolic comorbidities, in addition to TBI severity, are associated with the risk of post-traumatic development of Alzheimer disease dementia (ADD). A case-controlled retrospective study was conducted using medical records and medical insurance data of 5642 patients with TBI admitted to a tertiary trauma center over a 12-year period, to assess risk factors of developing ADD after TBI. Logistic regression shows that presence of post-traumatic amnesia ( P= 0.03) and chronic vascular lesions ( P= 0.04) are significantly associated with development of ADD after TBI. This innovative preliminary study is the first to explore risk factors for post-traumatic ADD. Further association studies are essential to optimize care following TBI. [ABSTRACT FROM AUTHOR]
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- 2022
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38. A critical role of brain network architecture in a continuum model of autism spectrum disorders spanning from healthy individuals with genetic liability to individuals with ASD
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Khundrakpam, Budhachandra, Bhutani, Neha, Vainik, Uku, Gong, Jinnan, Al-Sharif, Noor, Dagher, Alain, White, Tonya, and Evans, Alan C.
- Abstract
Studies have shown cortical alterations in individuals with autism spectrum disorders (ASD) as well as in individuals with high polygenic risk for ASD. An important addition to the study of altered cortical anatomy is the investigation of the underlying brain network architecture that may reveal brain-wide mechanisms in ASD and in polygenic risk for ASD. Such an approach has been proven useful in other psychiatric disorders by revealing that brain network architecture shapes (to an extent) the disorder-related cortical alterations. This study uses data from a clinical dataset—560 male subjects (266 individuals with ASD and 294 healthy individuals, CTL, mean age at 17.2 years) from the Autism Brain Imaging Data Exchange database, and data of 391 healthy individuals (207 males, mean age at 12.1 years) from the Pediatric Imaging, Neurocognition and Genetics database. ASD-related cortical alterations (group difference, ASD-CTL, in cortical thickness) and cortical correlates of polygenic risk for ASD were assessed, and then statistically compared with structural connectome-based network measures (such as hubs) using spin permutation tests. Next, we investigated whether polygenic risk for ASD could be predicted by network architecture by building machine-learning based prediction models, and whether the top predictors of the model were identified as disease epicenters of ASD. We observed that ASD-related cortical alterations as well as cortical correlates of polygenic risk for ASD implicated cortical hubs more strongly than non-hub regions. We also observed that age progression of ASD-related cortical alterations and cortical correlates of polygenic risk for ASD implicated cortical hubs more strongly than non-hub regions. Further investigation revealed that structural connectomes predicted polygenic risk for ASD (r= 0.30, p< 0.0001), and two brain regions (the left inferior parietal and left suparmarginal) with top predictive connections were identified as disease epicenters of ASD. Our study highlights a critical role of network architecture in a continuum model of ASD spanning from healthy individuals with genetic risk to individuals with ASD. Our study also highlights the strength of investigating polygenic risk scores in addition to multi-modal neuroimaging measures to better understand the interplay between genetic risk and brain alterations associated with ASD.
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- 2023
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39. Translation Rescue by Targeting Ppp1r15a through Its Upstream Open Reading Frame in Sepsis-Induced Acute Kidney Injury in a Murine Model
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Kidwell, Ashley, Yadav, Shiv Pratap Singh, Maier, Bernhard, Zollman, Amy, Ni, Kevin, Halim, Arvin, Janosevic, Danielle, Myslinski, Jered, Syed, Farooq, Zeng, Lifan, Waffo, Alain Bopda, Banno, Kimihiko, Xuei, Xiaoling, Doud, Emma H., Dagher, Pierre C., and Hato, Takashi
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- 2023
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40. Boston type I keratoprosthesis versus penetrating keratoplasty following a single failed corneal graft
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El-Khoury, Jonathan, Khair, Diana, Daoud, Roy, Thompson, Paul, Racine, Louis, and Harissi-Dagher, Mona
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Background/objectives: To compare long-term outcomes of the Boston type 1 keratoprosthesis (KPro) with penetrating keratoplasty (PKP) in patients with a failed first PKP. Subjects/Methods: In this retrospective comparative case series, 48 eyes of 48 patients who underwent a second corneal replacement procedure after a first failed PKP at the Centre Hospitalier de l’Université de Montréal from 2008 to 2020 were included. Minimum follow-up duration was 5 years, and patients with keratoconus were excluded since such subjects are not candidates for KPro. Main outcome measures included best-corrected visual acuity (BCVA), postoperative complications, graft survival and subsequent interventions. Results: Mean follow-up was 6.4 years for PKP and 9.6 years for KPro (p< 0.001). Preoperative BCVA was better in PKP patients (means 1.67 vs 2.13, p= 0.041). Visual outcomes were similar between groups. KPro patients developed 0.263 complication per patient-year (ppy) compared to 0.245 ppy or PKP. The most common complications for PKP were corneal complications (0.088 ppy) and glaucoma worsening (0.041 ppy). In KPro, glaucoma worsening (0.046 ppy), vitreoretinal complications (0.042 ppy) and retroprosthetic membrane (0.042 ppy) were the most frequent. Graft failure (69.6 vs 20.0%, p< 0.001) and reoperation rates (56.5 vs 12.0%, p= 0.001) were significantly higher for PKP. Failure mainly resulted from decompensation or rejection in PKP, while all five failures in KPro were caused by melt and/or extrusion. Conclusions: Both interventions showed similar visual outcomes. Complication profiles were different, with more posterior segment complications in the KPro group, and more corneal complications in the PKP group, often necessitating regraft.
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- 2023
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41. SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice
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Willekens, Christophe, Laplane, Lucie, Dagher, Tracy, Benlabiod, Camelia, Papadopoulos, Nicolas, Lacout, Catherine, Rameau, Philippe, Catelain, Cyril, Alfaro, Alexia, Edmond, Valérie, Signolle, Nicolas, Marchand, Valentine, Droin, Nathalie, Hoogenboezem, Remco, Schneider, Rebekka K., Penson, Alex, Abdel-Wahab, Omar, Giraudier, Stephane, Pasquier, Florence, Marty, Caroline, Plo, Isabelle, Villeval, Jean-Luc, Constantinescu, Stefan N., Porteu, Françoise, Vainchenker, William, and Solary, Eric
- Abstract
Heterozygous mutation targeting proline 95 in Serine/Arginine-rich Splicing Factor 2 (SRSF2) is associated with V617F mutation in Janus Activated Kinase 2 (JAK2) in some myeloproliferative neoplasms (MPNs), most commonly primary myelofibrosis. To explore the interaction of Srsf2P95Hwith Jak2V617F, we generated Cre-inducible knock-in mice expressing these mutants under control of the stem cell leukemia (Scl)gene promoter. In transplantation experiments, Srsf2P95Hunexpectedly delayed myelofibrosis induced by Jak2V617Fand decreased TGFβ1 serum level. Srsf2P95Hreduced the competitiveness of transplanted Jak2V617Fhematopoietic stem cells while preventing their exhaustion. RNA sequencing of sorted megakaryocytes identified an increased number of splicing events when the two mutations were combined. Focusing on JAK/STAT pathway, Jak2exon 14 skipping was promoted by Srsf2P95H, an event detected in patients with JAK2V617Fand SRSF2P95co-mutation. The skipping event generates a truncated inactive JAK2 protein. Accordingly, Srsf2P95Hdelays myelofibrosis induced by the thrombopoietin receptor agonist Romiplostim in Jak2wild-type animals. These results unveil JAK2exon 14 skipping promotion as a strategy to reduce JAK/STAT signaling in pathological conditions.
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- 2023
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42. The prognostic value of biomarker levels and chest imaging in patients with COVID-19 presenting to the emergency department.
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Dagher, Gilbert Abou, Ghanem, Alain Abi, Haidar, Saadeddine, Kattouf, Nadim, Assaf, Mohamad, Khdhir, Mihran, Chahine, Reve, Rizk, Jennifer, Makki, Maha, Tamim, Hani, and Chebl, Ralph Bou
- Abstract
Introduction: We aimed to compare the prognostic value of a quantitative CT severity score with several laboratory parameters, particularly C-reactive protein, Procalcitonin, Neutrophil to lymphocyte ratio, D-dimer, ferritin, lactate dehydrogenase, lactate, troponin and B-type Natriuretic Peptide in predicting in-hospital mortality.Methods: This was a retrospective chart review study of COVID-19 patients who presented to the Emergency Department of a tertiary care center between February and December 2020. All patients ≥18 years old who tested positive for the COVID-19 real-time reverse transcriptase polymerase chain reaction and underwent CT imaging at presentation were included. The primary outcome was the prognostic ability of CT severity score versus biomarkers in predicting in-hospital mortality.Results: The AUCs were: D-dimer (AUC: 0.67 95% CI = 0.57-0.77), CT severity score (0.66, 95% CI = 0.55-0.77), LDH (0.66, 95% CI = 0.55-0.77), Pro-BNP (0.65, 95% CI = 0.55-0.76), NLR (0.64, 95% CI = 0.53-0.75) and troponin (0.64, 95% CI = 0.52-0.75). In the stepwise logistic regression, age (OR = 1.07 95% CI = 1.05-1.09), obesity (OR = 2.02 95% CI = 1.25-3.26), neutrophil/lymphocyte ratio (OR = 1.02 95% CI = 1.01-1.04), CRP (OR = 1.01 95% CI = 1.004-1.01), lactate dehydrogenase (OR = 1.003 95% CI = 1.001-1.004) and CT severity score (OR = 1.17 95% CI = 1.12-1.23) were significantly associated with in-hospital mortality.Conclusion: In summary, CT severity score outperformed several biomarkers as a prognostic tool for covid related mortality. In COVID-19 patients requiring lung imaging, such as patients requiring ICU admission, patients with abnormal vital signs and those requiring mechanical ventilation, the results suggest obtaining and calculating the CT severity score to use it as a prognostic tool. If a CT was not performed, the results suggest using LDH, CRP or NLR if already done as prognostic tools in COVID-19 as these biomarkers were also found to be prognostic in COVID-19 patients. [ABSTRACT FROM AUTHOR]- Published
- 2022
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43. Resection of Hibernoma of the Proximal Shin Followed by Foot Drop and Tendon Transfer: A Case Report.
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Dagher, Michel, Maalouf, Rami George, and Tawk, Charbel
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This is the description of the case of a 42-year-old male who presented with a growing, painless lump on his anterior leg. The diagnosis of a rare tumor called hibernoma was suspected after inspection of the radiologic findings. The unusual location of the tumor resulted in superficial peroneal nerve entrapment. The tumor was excised and the diagnosis of hibernoma was confirmed by histopathology. Surgery resulted in foot drop that was successfully treated with a tibialis posterior tendon transfer. Our case illustrates a rare tumor in an unusual location that can be challenging for clinicians to discern and to properly treat. [ABSTRACT FROM AUTHOR]
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- 2022
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44. Aligning terrestrial habitat typology of Lebanon with EUNIS habitat classification
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El Zein, Hicham, Stephan, Jean, Khater, Carla, Al-Zein, Mohammad S., and Dagher-Kharrat, Magda Bou
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The absence of nationally accepted typology to classify and describe habitats has been an obstacle to the development of coordinated research in this field and to the implementation of conservation actions; therefore, a classification of the natural and semi-natural terrestrial habitat types existing in Lebanon is presented and adapted to the hierarchical structure of the European Nature Information System (EUNIS) habitat classification. The harmonisation with an international classification system is essential to facilitate communication and research throughout the Mediterranean Basin. A total of 1597 sites surveyed throughout Lebanon between 2013 and 2020 were classified and described based on the analysis of the physiognomic parameters and specific composition of their vegetation. The analysis yielded 190 habitat types for Lebanon, including 12 coastal habitats (category N), 35 related to inland surface waters (C), 6 wetland habitats (Q), 20 grasslands (R), 54 scrublands and heaths habitats (S), 27 types of woodlands (T), 17 inland unvegetated habitats (U), and 19 vegetated man-made habitats (V). Sixty-one habitats characteristic of Lebanon, not previously included in the EUNIS classification, were described and proposed in this typology. Those habitats include shrublands (23), woodlands (18), coastal habitats (6), wetlands (1), grasslands (9), sparsely vegetated habitats (2) and man-made vegetation (2).
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- 2022
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45. Energy analysis studying the effect of solar shading on daylight factors and cooling hours in an extreme weather
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Dagher, Sawsan, Akhozheya, Boshra, and Slimani, Hamza
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Solar heat gains contribute widely to the overheating in buildings, specifically in extreme climates. Climates which require large amounts of cooling energy during summer as well as heating energy during winter need to be carefully designed. Reducing solar transmittance through windows and improving building details/types can help minimize surface heat transfer. The use of shading to minimize solar transmission and heat gains through glazed and opaque surfaces is a strong method to reduce solar gains and can be an appropriate method to also improve thermal comfort in such extreme weathers. In the following paper, a method was followed in order to ensure thermal comfort without compromising the daylight factors inside. IESVE was used for the energy and daylighting analysis. Initially, a selected case study of a school building in Minneapolis was analyzed. Afterwards, a study was conducted using climate consultant to select the appropriate shading systems to be adopted. Next, selected classrooms were analyzed for the average daylight factor and solar heat gains pre and post applying the shading systems. The cooling hours were compared after the strategies were applied, a reduction up to 4% of cooling hours was seen post applying the shading devices. The correct study and application of shading devices can help reduce energy needs in summer, without increasing the heating loads in winter.
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- 2022
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46. Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
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Hansen, Justine Y., Shafiei, Golia, Markello, Ross D., Smart, Kelly, Cox, Sylvia M. L., Nørgaard, Martin, Beliveau, Vincent, Wu, Yanjun, Gallezot, Jean-Dominique, Aumont, Étienne, Servaes, Stijn, Scala, Stephanie G., DuBois, Jonathan M., Wainstein, Gabriel, Bezgin, Gleb, Funck, Thomas, Schmitz, Taylor W., Spreng, R. Nathan, Galovic, Marian, Koepp, Matthias J., Duncan, John S., Coles, Jonathan P., Fryer, Tim D., Aigbirhio, Franklin I., McGinnity, Colm J., Hammers, Alexander, Soucy, Jean-Paul, Baillet, Sylvain, Guimond, Synthia, Hietala, Jarmo, Bedard, Marc-André, Leyton, Marco, Kobayashi, Eliane, Rosa-Neto, Pedro, Ganz, Melanie, Knudsen, Gitte M., Palomero-Gallagher, Nicola, Shine, James M., Carson, Richard E., Tuominen, Lauri, Dagher, Alain, and Misic, Bratislav
- Abstract
Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.
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- 2022
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47. A Cardiac Surgeon’s View of Myocardial Viability in the Era of Multimodality Imaging
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Dagher, Olina, Ahsan, Muhammad, and Ali, Imtiaz S.
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- 2022
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48. Commentary: Restrictive mitral annuloplasty: What is certain about uncertainty?
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Dagher, Olina, Ben Ali, Walid, and Perrault, Louis P.
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- 2024
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49. Computed tomography assessment of postoperative gastric vascular supply and staple-line leak development after sleeve gastrectomy.
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Tranchart, Hadrien, Llouquet, Florence, Derienne, Joseph, Gaillard, Martin, Rafek, George, Grassin, Antoine, Voican, Cosmin Sebastian, Donatelli, Gianfranco, Rocher, Laurence, and Dagher, Ibrahim
- Abstract
Residual arterial supply of the gastric tube after sleeve gastrectomy (SG) can be damaged by surgery, which can reduce gastric tube perfusion and could promote postoperative leakage. To compare the postoperative vascularization of the gastric tube using early computed tomography (CT) scanning after SG in patients with or without postoperative staple-line leak. University hospital. A retrospective analysis of a prospective database was performed in consecutive patients undergoing SG. Patients who presented with a staple-line leak were matched (1:3) with a control group of patients who underwent surgery without postoperative morbidity during the same period. Gastric tube vascularization was studied on a postoperative day 2 CT scan in both groups of patients. During the study period, 1826 patients underwent SG , including 42 patients (2.3%) who presented with a staple-line leak. Those 42 patients were successfully matched to 126 control patients. Global identification of residual gastric arterial supply in early postoperative CT scans was similar in patients with or without staple-line leak after SG. However, residual vascular supply of the gastroesophageal junction (i.e., terminal and anterior cardiotuberosity branches of the left gastric artery or left inferior phrenic artery) was more frequently interrupted by the staple line in the group of patients who developed a gastric leak. This study suggests a correlation between interruption of the main arteries supplying the gastroesophageal junction by the staple line on early postoperative CT scans and the development of gastric leak after SG. These results support the vascular theory as one of the causes of leak after SG. [ABSTRACT FROM AUTHOR]
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- 2022
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50. Comparison of outcomes in patients with and without soft contact lens wear following Boston keratoprosthesis type 1.
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Liu, Jiaru and Harissi-Dagher, Mona
- Abstract
Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
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