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143 results on '"Díaz Luis, P."'

3. Incidence of metabolic bone disease in neonates under 32 gestational weeks at the Hospital Universitario de Santander in Colombia.

Author

Ruiz, Erika, Ernesto Piamonte, Diego, Tatiana Gómez, Deisy, Alfonso Díaz, Luis, and Alfonso Pérez, Luis

Subjects
METABOLIC bone disorders, PREMATURE infants, NEWBORN infants, ALKALINE phosphatase, PARENTERAL feeding, MATERNAL age
Abstract

Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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4. Glass with a low-melting temperature belonging to the P2O5–CaO–Na2O system, applied as a coating on technical ceramics (alumina, zirconia) and traditional ceramics (porcelain stoneware)

Author

Díaz, Luis Antonio, Suárez, Marta, Bartolomé, Jose Florindo, Lopez-Esteban, Sonia, Cabal, Belén, Moreno, Arnaldo, Bordes, María del Carmen, Fernández, Adolfo, Pecharromán, Carlos, and Moya, José Serafin

Abstract

This article investigates the development and potential applications of low-melting point lead-free glasses. Their importance is due to strong market demands to comply with the strict international regulations against the use of lead. In this work, a preliminary study of the existing interactions of a low-melting-temperature glass belonging to the P2O5–CaO–Na2O system when it is deposited on different ceramic substrates, both traditional (porcelain stoneware) and technical (alumina and zirconia), has been carried out. The ionic diffusion through the studied interfaces, the phases present, the composition of the glassy phase and the surface morphology of the coating have been studied by Field Emission Scanning Electron Microscopy (FESEM), with coupled EDX microanalysis. The chemical resistance of the different glassy coatings obtained is also evaluated. The results showed that these new lead-free low-melting-temperature glassy coatings are chemically and mechanically compatible, and promising candidates for applications and markets in a broad range of fields.

Published
2024
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5. Behandlungsstrategien bei Patient:innen mit Alkoholkonsumstörung und eingeschränkter Leberfunktion

Author

Sommer, Lea, Weber, Sabine, Díaz, Luis Antonio, Trojer, Armin, Listabarth, Stephan, Groemer, Magdalena, Arab, Juan Pablo, and König, Daniel

Abstract

Neben psychosozialer und psychotherapeutischer Betreuung stehen in der Behandlung von Alkoholkonsumstörungen auch Psychopharmaka zur Verfügung. Trotz Zulassung und Evidenz über wirksame Unterstützung zur Aufrechterhaltung der Alkoholabstinenz wird diese Behandlungsoption oft erst verspätet, wenn sich bereits Folgeerkrankungen, insbesondere alkoholbedingte Lebererkrankungen (ALE) manifestiert haben, oder teilweise gar nicht angeboten. Die weitere Behandlung der Alkoholkonsumstörungen kann dadurch zusätzlich verkompliziert werden. Als mögliche Ursachen für den verspäteten Einsatz von Psychopharmaka in diesem Zusammenhang werden unter anderem ein mangelhafter Wissensstand und Stigmatisierung innerhalb des medizinischen Personals beschrieben. Die vorliegende Arbeit soll daher einen Überblick über wichtige Teilaspekte der multidisziplinären und integrativen Betreuung bei Alkoholkonsumstörung verschaffen.

Published
2024
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6. Ongoing declines for the world’s amphibians in the face of emerging threats

Author

Luedtke, Jennifer A., Chanson, Janice, Neam, Kelsey, Hobin, Louise, Maciel, Adriano O., Catenazzi, Alessandro, Borzée, Amaël, Hamidy, Amir, Aowphol, Anchalee, Jean, Anderson, Sosa-Bartuano, Ángel, Fong G., Ansel, de Silva, Anslem, Fouquet, Antoine, Angulo, Ariadne, Kidov, Artem A., Muñoz Saravia, Arturo, Diesmos, Arvin C., Tominaga, Atsushi, Shrestha, Biraj, Gratwicke, Brian, Tjaturadi, Burhan, Martínez Rivera, Carlos C., Vásquez Almazán, Carlos R., Señaris, Celsa, Chandramouli, S. R., Strüssmann, Christine, Cortez Fernández, Claudia Fabiola, Azat, Claudio, Hoskin, Conrad J., Hilton-Taylor, Craig, Whyte, Damion L., Gower, David J., Olson, Deanna H., Cisneros-Heredia, Diego F., Santana, Diego José, Nagombi, Elizah, Najafi-Majd, Elnaz, Quah, Evan S. H., Bolaños, Federico, Xie, Feng, Brusquetti, Francisco, Álvarez, Francisco S., Andreone, Franco, Glaw, Frank, Castañeda, Franklin Enrique, Kraus, Fred, Parra-Olea, Gabriela, Chaves, Gerardo, Medina-Rangel, Guido F., González-Durán, Gustavo, Ortega-Andrade, H. Mauricio, Machado, Iberê F., Das, Indraneil, Dias, Iuri Ribeiro, Urbina-Cardona, J. Nicolas, Crnobrnja-Isailović, Jelka, Yang, Jian-Huan, Jianping, Jiang, Wangyal, Jigme Tshelthrim, Rowley, Jodi J. L., Measey, John, Vasudevan, Karthikeyan, Chan, Kin Onn, Gururaja, Kotambylu Vasudeva, Ovaska, Kristiina, Warr, Lauren C., Canseco-Márquez, Luis, Toledo, Luís Felipe, Díaz, Luis M., Khan, M. Monirul H., Meegaskumbura, Madhava, Acevedo, Manuel E., Napoli, Marcelo Felgueiras, Ponce, Marcos A., Vaira, Marcos, Lampo, Margarita, Yánez-Muñoz, Mario H., Scherz, Mark D., Rödel, Mark-Oliver, Matsui, Masafumi, Fildor, Maxon, Kusrini, Mirza D., Ahmed, Mohammad Firoz, Rais, Muhammad, Kouamé, N’Goran G., García, Nieves, Gonwouo, Nono Legrand, Burrowes, Patricia A., Imbun, Paul Y., Wagner, Philipp, Kok, Philippe J. R., Joglar, Rafael L., Auguste, Renoir J., Brandão, Reuber Albuquerque, Ibáñez, Roberto, von May, Rudolf, Hedges, S. Blair, Biju, S. D., Ganesh, S. R., Wren, Sally, Das, Sandeep, Flechas, Sandra V., Ashpole, Sara L., Robleto-Hernández, Silvia J., Loader, Simon P., Incháustegui, Sixto J., Garg, Sonali, Phimmachak, Soumphthone, Richards, Stephen J., Slimani, Tahar, Osborne-Naikatini, Tamara, Abreu-Jardim, Tatianne P. F., Condez, Thais H., De Carvalho, Thiago R., Cutajar, Timothy P., Pierson, Todd W., Nguyen, Truong Q., Kaya, Uğur, Yuan, Zhiyong, Long, Barney, Langhammer, Penny, and Stuart, Simon N.

Abstract

Systematic assessments of species extinction risk at regular intervals are necessary for informing conservation action1,2. Ongoing developments in taxonomy, threatening processes and research further underscore the need for reassessment3,4. Here we report the findings of the second Global Amphibian Assessment, evaluating 8,011 species for the International Union for Conservation of Nature Red List of Threatened Species. We find that amphibians are the most threatened vertebrate class (40.7% of species are globally threatened). The updated Red List Index shows that the status of amphibians is deteriorating globally, particularly for salamanders and in the Neotropics. Disease and habitat loss drove 91% of status deteriorations between 1980 and 2004. Ongoing and projected climate change effects are now of increasing concern, driving 39% of status deteriorations since 2004, followed by habitat loss (37%). Although signs of species recoveries incentivize immediate conservation action, scaled-up investment is urgently needed to reverse the current trends.

Published
2023
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7. Gastrointestinal symptoms and complications in patients hospitalized due to COVID-19, an international multicentre prospective cohort study (TIVURON project)

Author

Cárdenas-Jaén, Karina, Sánchez-Luna, Sergio A., Vaillo-Rocamora, Alicia, Castro-Zocchi, Micaela Riat, Guberna-Blanco, Laura, Useros-Brañas, Daniel, Remes-Troche, José M., Ramos-De la Medina, Antonio, Priego-Parra, Bryan A., Velarde-Ruiz Velasco, José A., Martínez-Ayala, Pedro, Urzúa, Álvaro, Guiñez-Francois, Dannette, Pawlak, Katarzyna M., Kozłowska-Petriczko, Katarzyna, Gorroño-Zamalloa, Irati, Urteaga-Casares, Clara, Ortiz-Polo, Inmaculada, del Val Antoñana, Adolfo, Lozada-Hernández, Edgard E., Obregón-Moreno, Enrique, García-Rayado, Guillermo, Domper-Arnal, María José, Casas-Deza, Diego, Esteban-Cabello, Elena I., Díaz, Luis A., Riquelme, Arnoldo, Martínez-Lozano, Helena, Navarro-Romero, Francisco, Olivas, Ignasi, Iborra-Muñoz, Guillem, Calero-Amaro, Alicia, Caravaca-García, Ibán, Lacueva-Gómez, Francisco J., Pastor-Mateu, Rubén, Lapeña-Muñoz, Berta, Sastre-Lozano, Violeta, Pizarro-Vega, Nazaret M., Melcarne, Luigi, Pedrosa-Aragón, Marc, Mira, José J., MStat, Aurora Mula, Carrillo, Irene, and de-Madaria, Enrique

Abstract

Retrospective studies suggest that coronavirus disease (COVID-19) commonly involves gastrointestinal (GI) symptoms and complications. Our aim was to prospectively evaluate GI manifestations in patients hospitalized for COVID-19.

Published
2023
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8. Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life

Author

Santos-García, Diego, de Deus Fonticoba, Teresa, Cores Bartolomé, Carlos, Feal Painceiras, Maria J., Íñiguez-Alvarado, Maria Cristina, García Díaz, Iago, Jesús, Silvia, Buongiorno, Maria Teresa, Planellas, Lluís, Cosgaya, Marina, García Caldentey, Juan, Caballol, Nuria, Legarda, Ines, Hernández Vara, Jorge, Cabo, Iria, López Manzanares, Lydia, González Aramburu, Isabel, Ávila Rivera, Maria A., Gómez Mayordomo, Víctor, Nogueira, Víctor, Puente, Víctor, Dotor García-Soto, Julio, Borrué, Carmen, Solano Vila, Berta, Álvarez Sauco, María, Vela, Lydia, Escalante, Sonia, Cubo, Esther, Carrillo Padilla, Francisco, Martínez Castrillo, Juan C., Sánchez Alonso, Pilar, Alonso Losada, Maria G., López Ariztegui, Nuria, Gastón, Itziar, Kulisevsky, Jaime, Menéndez González, Manuel, Seijo, Manuel, Ruiz Martínez, Javier, Valero, Caridad, Kurtis, Mónica, González Ardura, Jessica, Alonso Redondo, Ruben, Ordás, Carlos, López Díaz, Luis M., McAfee, Darrian, Calopa, Matilde, Carrillo, Fátima, Escamilla Sevilla, Francisco, Freire-Alvarez, Eric, Gómez Esteban, Juan Carlos, García Ramos, Rocío, Luquín, María Rosario Isabel, Martínez-Torres, Irene, Sesar Ignacio, Ángel, Martinez-Martin, Pablo, and Mir, Pablo

Abstract

Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort fromJanuary 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL:1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Four hundred and thirty-nine PD patients (62.05±7.84 years old; 59% males) were included. MNCD stage was:stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advancedMNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p< 0.0001) and EUROHIS-QOL8 (p< 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD.

Published
2023
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9. (D)AICLE: un enfoque digital sobre el aprendizaje integrado de contenidos y lengua extranjera

Author

Díaz-Luis, Natacha R. and Francisco-Déniz, Sergio D.

Abstract

RESUMENLa realidad actual, caracterizada por el empleo de herramientas digitales para una gran cantidad de objetivos y la interconexión e intercomunicación como fruto de la globalización, dichos medios digitales han adquirido mayor protagonismo debido a la pandemia por COVID-19. En este contexto, la escuela busca constituirse como un modelo de imitación sociológica con el fin de preparar a los/as discentes a las circunstancias profesionales, políticas, económicas, sociales y culturales. Por estos motivos, esta investigación se ha diseñado desde una perspectiva competencial. Se ha seleccionado un programa educativo AICLE y se ha propuesto la enseñanza- aprendizaje de la digitalización y las áreas que las componen mediante un grupo perteneciente a 2° de Educación Secundaria en un centro de Santa Cruz de Tenerife, poniéndose en práctica una situación de aprendizaje en que acoge aspectos digitales en el enfoque AICLE en la materia de Geografía e Historia. De tal intervención didáctica, se han extraído resultados cualitativos y cuantitativos que han favorecido el posterior debate sobre el éxito de coordinar lengua extranjera y herramientas digitales como medios de enseñanza- aprendizaje con metodologías cooperativas y Aprendizaje Basado en Proyectos (ABP).

Published
2023
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10. Changes in Principal Caregiver Mood Affects the Mood of the Parkinson’s Disease Patient: The Vicious Cycle of Illness

Author

Santos-García, Diego, de Deus Fonticoba, Teresa, Cores Bartolomé, Carlos, Feal Painceiras, Maria J., Íñiguez-Alvarado, Maria Cristina, García Díaz, Iago, Jesús, Silvia, Buongiorno, Maria Teresa, Planellas, Lluís, Cosgaya, Marina, García Caldentey, Juan, Caballol, Nuria, Legarda, Ines, Hernández Vara, Jorge, Cabo, Iria, López Manzanares, Lydia, González Aramburu, Isabel, Ávila Rivera, Maria A., Gómez Mayordomo, Víctor, Nogueira, Víctor, Puente, Víctor, Dotor García-Soto, Julio, Borrué, Carmen, Solano Vila, Berta, Álvarez Sauco, María, Vela, Lydia, Escalante, Sonia, Cubo, Esther, Carrillo Padilla, Francisco, Martínez Castrillo, Juan C., Sánchez Alonso, Pilar, Alonso Losada, Maria G., López Ariztegui, Nuria, Gastón, Itziar, Kulisevsky, Jaime, Menéndez González, Manuel, Seijo, Manuel, Rúiz Martínez, Javier, Valero, Caridad, Kurtis, Mónica, González Ardura, Jessica, Alonso Redondo, Ruben, Ordás, Carlos, López Díaz, Luis M., McAfee, Darrian, Martinez-Martin, Pablo, and Mir, Pablo

Published
2023
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11. Activating de novomonoallelic variants causing inborn errors of immunity in two unrelated children born of HIV-seroconcordant couples

Author

Lugo Reyes, Saul O., Solórzano Suárez, Andrea, Scheffler Mendoza, Selma C., Xóchihua Díaz, Luis, González Serrano, M. Edith, López Herrera, Gabriela, Medina-Torres, Edgar Alejandro, Cruz Ugalde, Claudia I., Olguín-Calderón, Diana, Berrón Ruiz, Laura, Espinosa-Padilla, Sara E., Yamazaki-Nakashimada, Marco Antonio, and Murata, Chiharu

Published
2022
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13. Characterization of hereditary transthyretin cardiac amyloidosis in Spain.

Author

Álvarez Rubio, Jorge, Manovel Sánchez, Ana José, González-Costello, José, García-Pavía, Pablo, Limeres Freire, Javier, García-Pinilla, José Manuel, Zorio Grima, Esther, García-Álvarez, Ana, Valverde Gómez, María, Espinosa Castro, M. Ángeles, Barge-Caballero, Gonzalo, Gimeno Blanes, Juan Ramón, Bosch Rovira, María Teresa, Rincón Díaz, Luis Miguel, Aibar Arregui, Miguel Ángel, Gallego-Delgado, María, Jiménez-Jáimez, Juan, Martínez Moreno, Marina, Basurte, Mayte, and Arana Achaga, Xabier

Abstract

Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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14. Un juego de inversión con información completa e incompleta aplicado al mercado eléctrico.

Author

García Mazo, Claudia María, Ramírez Díaz, Luis Francisco, and Monsalve Lozano, Bernardo Antonio

Subjects
DECISION making in investments, ELECTRICITY markets, GAME theory, MARKET volatility, INFORMATION asymmetry, ELECTRIC power production
Abstract

Copyright of Contaduría y Administración is the property of Facultad de Contaduria y Administracion-Universidad Nacional Autonoma de Mexico and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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16. Photoprotection-related properties of a raw extract from Gordonia hongkongensisEUFUS-Z928: A culturable rare actinomycete associated with the Caribbean octocoral Eunicea fusca

Author

Sánchez-Suárez, Jeysson, Villamil, Luisa, Coy-Barrera, Ericsson, and Díaz, Luis

Abstract

UV filters in current sunscreen formulations can have negative effects on human health, such as endocrine disruption and allergic reactions, as well as on the environment, including bioaccumulation and coral health toxicity. As a result, there is a need to find alternative compounds that serve as safer and more ecofriendly active ingredients. This study successfully isolated actinomycetes from the octocoral Eunicea fuscaand assessed their potential as producers of photoprotective compounds. The use of bio-based chemical agents, particularly natural products, has been a highly effective strategy for discovering bioactive compounds, especially in marine invertebrates and their associated microbiota. Eighteen bacterial isolates were obtained and subsequently employed to prepare raw methanolic extracts from seven-day submerged cultures in Zobell marine broth. The resulting extracts were screened for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging capacity and characterized by total phenolic and flavonoid content measurements. After screening, the Gordonia hongkongensisEUFUS-Z928-derived raw extract exhibited the best antioxidant profile, i.e. DPPH and ABTS radical scavenging of 4.93 and 6.00 µmol Trolox per gram of extract, respectively, and selected for further photoprotection-related analysis. Thus, this extract demonstrated a UV-absorbing capacity of 46.33% of the in vitrosun protection factor calculated for 30 µg/mL oxybenzone but did not exhibit any cytotoxicity on human dermal fibroblasts (HDFa cell line) at concentrations up to 500 µg/mL. The liquid chromatography-mass spectrometry chemical characterization of this extract showed compounds with structural features associated with free radical scavenging and UV absorption (i.e. photoprotection-related activities). These findings highlighted the potential of the microbiota associated with E. fuscaand confirmed the feasibility of exploiting its metabolites for photoprotection-related purposes.

Published
2024
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17. Controlling Doxorubicin Release from a Peptide Hydrogel through Fine-Tuning of Drug–Peptide Fiber Interactions

Author

Elsawy, Mohamed A., Wychowaniec, Jacek K., Castillo Díaz, Luis A., Smith, Andrew M., Miller, Aline F., and Saiani, Alberto

Abstract

Hydrogels are versatile materials that have emerged in the last few decades as promising candidates for a range of applications in the biomedical field, from tissue engineering and regenerative medicine to controlled drug delivery. In the drug delivery field, in particular, they have been the subject of significant interest for the spatially and temporally controlled delivery of anticancer drugs and therapeutics. Self-assembling peptide-based hydrogels, in particular, have recently come to the fore as potential candidate vehicles for the delivery of a range of drugs. In order to explore how drug–peptide interactions influence doxorubicin (Dox) release, five β-sheet-forming self-assembling peptides with different physicochemical properties were used for the purpose of this study, namely: FEFKFEFK (F8), FKFEFKFK (FK), FEFEFKFE (FE), FEFKFEFKK (F8K), and KFEFKFEFKK (KF8K) (F: phenylalanine; E: glutamic acid; K: lysine). First, Dox-loaded hydrogels were characterized to ensure that the incorporation of the drug did not significantly affect the hydrogel properties. Subsequently, Dox diffusion out of the hydrogels was investigated using UV absorbance. The amount of drug retained in F8/FE composite hydrogels was found to be directly proportional to the amount of charge carried by the peptide fibers. When cation−π interactions were used, the position and number of end-lysine were found to play a key role in the retention of Dox. In this case, the amount of Dox retained in F8/KF8K composite hydrogels was linked to the amount of end-lysine introduced, and an end-lysine/Dox interaction stoichiometry of 3/1 was obtained. For pure FE and KF8K hydrogels, the maximum amount of Dox retained was also found to be related to the overall concentration of the hydrogels and, therefore, to the overall fiber surface area available for interaction with the drug. For 14 mM hydrogel, ∼170–200 μM Dox could be retained after 24 h. This set of peptides also showed a broad range of susceptibilities to enzymatic degradation opening the prospect of being able to control also the rate of degradation of these hydrogels. Finally, the Dox released from the hydrogel was shown to be active and affect 3T3 mouse fibroblasts viability in vitro. Our study clearly shows the potential of this peptide design as a platform for the formulation of injectable or sprayable hydrogels for controlled drug delivery.

Published
2022
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18. The establishment of public health policies and the burden of non-alcoholic fatty liver disease in the Americas

Author

Díaz, Luis Antonio, Fuentes-López, Eduardo, Ayares, Gustavo, Idalsoaga, Francisco, Arnold, Jorge, Márquez-Lomas, Andrea, Ramírez, Carolina A, Medel, María Paz, Viñuela, Francisca, Lacalle, Lucas, Roblero, Juan Pablo, Ferreccio, Catterina, Lazo, Mariana, Brahmania, Mayur, Singal, Ashwani K, Dirchwolf, Melisa, Méndez-Sánchez, Nahum, Chavez-Tapia, Norberto, Guerra, Patricia, Restrepo, Juan Carlos, Oliveira, Claudia P, Lombardo, Julissa, Sánchez, Abel, Elizondo, Martín, Tagle, Martín, Padilla, Martín, Sánchez, Marco, Carrera, Enrique, Girala, Marcos, Chery, Omega, Castellanos-Fernández, Marlen, Barrera, Francisco, Lazarus, Jeffrey V, Kamath, Patrick S, Bataller, Ramon, Arrese, Marco, and Arab, Juan Pablo

Abstract

Non-alcoholic fatty liver disease (NAFLD) affects 20–25% of the general population and is associated with morbidity, increased mortality, and elevated health-care costs. Most NAFLD risk factors are modifiable and, therefore, potentially amenable to being reduced by public health policies. To date, there is no information about NAFLD-related public health policies in the Americas. In this study, we analysed data from 17 American countries and found that none have established national public health policies to decrease NAFLD-related burden. There is notable heterogeneity in the existence of public health policies to prevent NAFLD-related conditions. The most common public health policies were related to diabetes (15 [88%] countries), hypertension (14 [82%] countries), cardiovascular diseases (14 [82%] countries), obesity (nine [53%] countries), and dyslipidaemia (six [35%] of countries). Only seven (41%) countries had a registry of the burden of NAFLD, and efforts to raise awareness in the Americas were scarce. The implementation of public health policies are urgently needed in the Americas to decrease the burden of NAFLD.

Published
2022
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19. Parkinson’s Disease Motor Subtypes Change with the Progression of the Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up

Author

Santos García, Diego, Canfield, Hector, de Deus Fonticoba, Teresa, Cores Bartolomé, Carlos, Naya Ríos, Lucía, García Roca, Lucía, Martínez Miró, Cristina, Jesús, Silvia, Aguilar, Miquel, Pastor, Pau, Cosgaya, Marina, García Caldentey, Juan, Caballol, Nuria, Legarda, Inés, Hernández Vara, Jorge, Cabo, Iria, López Manzanares, Lydia, González Aramburu, Isabel, Ávila Rivera, María A., Gómez Mayordomo, Víctor, Nogueira, Víctor, Puente, Víctor, Dotor, Julio, Borrué, Carmen, Solano Vila, Berta, Álvarez Sauco, María, Vela, Lydia, Escalante, Sonia, Cubo, Esther, Carrillo Padilla, Francisco, Martínez Castrillo, Juan C., Sánchez Alonso, Pilar, Alonso Losada, Maria G., López Ariztegui, Nuria, Gastón, Itziar, Kulisevsky, Jaime, Blázquez Estrada, Marta, Seijo, Manuel, Rúiz Martínez, Javier, Valero, Caridad, Kurtis, Mónica, de Fábregues, Oriol, González Ardura, Jessica, Alonso Redondo, Ruben, Ordás, Carlos, López Díaz, Luis M., McAfee, Darrian, Martinez-Martin, Pablo, and Mir, Pablo

Abstract

Motor phenotype (MP) can be associated with a different prognosis in Parkinson’s disease (PD), but it is not fixed and can change over time. Our aim was to analyze how the MP changed over time and to identify factors associated with the changes in PD patients from a multicenter Spanish PD cohort. PD patients who were recruited from January-2016 to November-2017 (baseline visit; V0) and evaluated again at a 2-year±30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this study.MP was calculated at both visits based on Jankovic classification in TD (tremor dominant), IND (indeterminate), or PIGD (postural instability and gait difficulty). Sociodemographic and clinical data were collected, including serum biomarkers. Five hundred eleven patients (62.57±8.59 years old; 59.2%males) were included in the study. At V0, MP was: 47.4%(242/511) TD; 36.6%(187/511) PIGD; 16%(82/511) IND. Up to 38%(194/511) of the patients changed their phenotype from V0 to V2, being the most frequent from TD to IND (8.4%) and from TD to PIGD (6.7%). A worse cognitive status (OR = 0.966) and less autonomy for activities of daily living (OR  =  0.937) at V0 and a greater increase in the globalNMS burden (OR  =  1.011) from V0 to V2 were associated with changing from TD to another phenotype after 2-year follow-up. The MP in PD can change over time. With disease progression, the percentage of cases with non-tremoric MP increases. PD patients who changed from TD to postural instability and gait difficulty increased NMS burden significantly.

Published
2022
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20. The Mortality Index for Alcohol-Associated Hepatitis: A Novel Prognostic Score

Author

Kezer, Camille A., Buryska, Seth M., Ahn, Joseph C., Harmsen, William S., Dunn, Winston, Singal, Ashwani K., Arab, Juan P., Díaz, Luis A., Arnold, Jorge, Kamath, Patrick S., Shah, Vijay H., and Simonetto, Douglas A.

Abstract

To develop a new scoring system that more accurately predicts 30-day mortality in patients with alcohol-associated hepatitis (AH).

Published
2022
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21. Morphological evaluations in buffaloes (Bubalus bubalis) in Venezuela.

Author

Pacheco-Díaz, Luis Alfredo, Aranguren-Méndez, José Atilio, Román-Bravo, Rafael, Rivero-Hernández, Sharon, and Tovar-Briceño, Luis Edgardo

Subjects
WATER buffalo, ANIMAL morphology
Abstract

Copyright of Revista Cientifica de la Facultade de Veterinaria is the property of Universidad del Zulia, Facultad de Ciencias Veterinarias and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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22. Buffalo genetic improvement program in Venezuela.

Author

Aranguren-Méndez, José A., Román-Bravo, Rafael M., Briceño-Rojas, Ricardo A., Briceño-Rojas, Mauricio G., and Pacheco-Díaz, Luis A.

Subjects
WATER buffalo, LIVESTOCK genetics
Abstract

Copyright of Revista Cientifica de la Facultade de Veterinaria is the property of Universidad del Zulia, Facultad de Ciencias Veterinarias and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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23. Realising potentials for arts-based sustainability science

Author

Heras, María, Galafassi, Diego, Oteros-Rozas, Elisa, Ravera, Federica, Berraquero-Díaz, Luis, and Ruiz-Mallén, Isabel

Abstract

In recent years, a profusion of methods, practices, and experiences has emerged in the interface between arts and sustainability science. Drawing from two strong currents within sustainability science, namely, the emphasis on transdisciplinary approaches and the need to move towards societal transformations, such hybrid approaches seemingly contribute with unique methods to sustainability research. Despite repeated claims from sustainability scientists about art’s role in sustainability transformations, joint analyses with artists and practitioners are still rare. We conveyed a collaborative and exploratory workshop with scientists, artists, and practitioners from the fields of education, public engagement, and activism to identify the potentials for arts-based sustainability research. Participants were invited to facilitate and trial various artistic practices from disciplines of performative, literary, narrative, audio-visual and plastic arts. In this paper, we present five key areas identified in the workshop, where arts-based methods can significantly contribute to sustainability research: embracing more-than-cognitive aspects of knowledge, improving communication, grappling with power dynamics, shifting relationships to nature, and facilitating futures visioning. Workshop participants also identified challenges related to power dynamics, tensions across paradigms, and implementation conditions, providing insights into how to leverage arts’ potential to respond to global environmental challenges while boosting societal transformations. We then discuss research questions identified that address challenges and limitations for arts-based research in sustainability. Overall, these results suggest there are yet untapped resources and experiences within the field of arts-based sustainability science. (Audio-visual abstract available on S1)

Published
2021
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24. Risk predictors in a Spanish cohort with cardiac laminopathies. The REDLAMINA registry.

Author

Barriales-Villa, Roberto, Ochoa, Juan P., Larrañaga-Moreira, José M., Salazar-Mendiguchía, Joel, Díez-López, Carles, Restrepo-Córdoba, María Alejandra, Álvarez-Rubio, Jorge, Robles-Mezcua, Ainhoa, Olmo-Conesa, María C., Nicolás-Rocamora, Elisa, Sanz, Jorge, Villacorta, Eduardo, Gallego-Delgado, María, Yotti, Raquel, Espinosa, María Ángeles, Manovel, Ana, Rincón-Díaz, Luis M., Jiménez-Jaimez, Juan, Bermúdez-Jiménez, Francisco J., and Basurte-Elorz, M. Teresa

Abstract

Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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25. Acute Liver Injury Among Pediatric Liver Transplantation Recipients With Coronavirus Disease 2019

Author

Sin, Priscila, Díaz, Luis Antonio, Martínez, Mercedes, Vizcaya, Cecilia, D'Agostino, Daniel, and Gana, Juan Cristóbal

Abstract

Coronavirus disease 2019 (COVID-19) is an ongoing pandemic. The occurrence of acute liver injury (ALI) has been reported in liver transplant (LT) recipients; however, the findings on children remain controversial. This is the first extensive, worldwide report on the impact of COVID-19 on pediatric LT recipients. Our online survey reported 110 pediatric LT recipients with severe acute respiratory syndrome coronavirus 2 infection. Of these, 37 were symptomatic and 20 out of them (54%) had complicated COVID-19, which included ALI and acute liver graft rejection. No mortality was reported. Pediatric LT recipients who had undergone transplantation less than 6 months before contracting COVID-19 had a greater number of hospital admissions and a higher ALI frequency (P= 0.013 and P= 0.033, respectively) than those who had undergone transplantation more than 6 months prior. Our study found that COVID-19 cases among pediatric LT recipients demonstrated a high complication rate. We propose that these patients must be followed up strictly.

Published
2021
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27. Optimized carotenoid production and antioxidant capacity of Gordonia hongkongensis

Author

Rhenals-Montoya, Paula, Villamil, Luisa, Sánchez-Suárez, Jeysson, Díaz, Luis, and Coy-Barrera, Ericsson

Abstract

The current emphasis within the cosmetic market on sustainable ingredients has heightened the exploration of new sources for natural, active components. Actinomycetota, recognized for producing pigments with bioactive potential, offer promising functional cosmetic ingredients. This study aimed to optimize pigment and antioxidant metabolite production from the Gordonia hongkongensisstrain EUFUS-Z928 by implementing the Plackett-Burman experimental design and response surface methodology. Extracts derived from this strain exhibited no cytotoxic activity against human primary dermal fibroblast (HDFa, ATCC® PCS-201-012™, Primary Dermal Fibroblast; Normal, Human, Adult). Eight variables, including inoculum concentration, carbon and nitrogen source concentration, NaCl concentration, pH, incubation time, temperature, and stirring speed, were analyzed using the Plackett-Burman experimental design. Subsequently, factors significantly influencing pigment and antioxidant metabolite production, such as temperature, inoculum concentration, and agitation speed, were further optimized using response surface methodology and Box-Behnken design. The results demonstrated a substantial increase in absorbance (from 0.091 to 0.32), DPPH radical scavenging capacity (from 27.60% to 84.61%), and ABTS radical scavenging capacity (from 17.39% to 79.77%) compared to responses obtained in the isolation medium. The validation of the mathematical model accuracy exceeded 90% for all cases. Furthermore, liquid chromatography coupled with mass spectrometry (LC-MS) facilitated the identification of compounds potentially responsible for enhanced pigment production and antioxidant capacity in extracts derived from G. hongkongensis. Specifically, six carotenoids, red-orange pigments with inherent antioxidant capacity, were identified as the main enhanced compounds. This comprehensive approach effectively optimized the culture conditions and medium of a G. hongkongensisstrain, resulting in enhanced carotenoid production and antioxidant capacity. Beyond identifying bioactive compounds and their potential cosmetic applications, this study offers insights into the broader industrial applicability of these extracts. It underscores the potential of G. hongkongensisand hints at the future utilization of other untapped sources of rare actinomycetes within the industry.

Published
2024
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30. Global multi-stakeholder endorsement of the MAFLD definition

Author

Méndez-Sánchez, Nahum, Bugianesi, Elisabetta, Gish, Robert G, Lammert, Frank, Tilg, Herbert, Nguyen, Mindie H, Sarin, Shiv K, Fabrellas, Núria, Zelber-Sagi, Shira, Fan, Jian-Gao, Shiha, Gamal, Targher, Giovanni, Zheng, Ming-Hua, Chan, Wah-Kheong, Vinker, Shlomo, Kawaguchi, Takumi, Castera, Laurent, Yilmaz, Yusuf, Korenjak, Marko, Spearman, C Wendy, Ungan, Mehmet, Palmer, Melissa, El-Shabrawi, Mortada, Gruss, Hans-Juergen, Dufour, Jean-François, Dhawan, Anil, Wedemeyer, Heiner, George, Jacob, Valenti, Luca, Fouad, Yasser, Romero‐Gomez, Manuel, Eslam, Mohammed, Abate, Maria Lorena, Abbas, Bahaa, Abbassy, Ahmed Amr, Abd El Ghany, Waleed, Abd Elkhalek, Amira, Abd ElMajeed, Emad, Abdalgaber, Mohammad, AbdAllah, Mohamed, Abdallah, Marwa, Abdallah, Nourhan, Abdelaleem, Shereen, Abdelghani, Yasser, Abdelghany, Wael, Abdelhalim, Safaa Mohamed, Abdelhamid, Wafaa, Abdelhamid, Nehal, Abdelkader, Nadia A., Abdelkreem, Elsayed, Abdelmohsen, Aly Mohamed, Abdelrahman, Awny Ali, Abd-elsalam, Sherief M, Abdeltawab, Doaa, Abduh, Abdulbaset, Abdulhakam, Nada, Abdulla, Maheeba, Abedpoor, Navid, Abenavoli, Ludovico, Åberg, Fredrik, Ablack, Omala, Abo elftouh, Mostafa, Abo-Amer, Yousry Esam-Eldin, Aboubkr, Ashraf, Aboud, Alaa, Abouelnaga, Amr M., Aboufarrag, Galal A., Aboutaleb, Ashraf, Abundis, Leticia, Adalı, Gupse, Adames, Enrique, Adams, Leon, Adda, Danjuma, Adel, Noor, Adel, Nada, Adel Sayed, Muhammad, Afaa, Taiba Jibril, Afredj, Nawal, Aghayeva, Gulnara, Aghemo, Alessio, Aguilar-Salinas, Carlos A., Ahlenstiel, Golo, Ahmady, Walid, Ahmed, Wafaa, Ahmed, Amira, Ahmed, Samah Nasser, Ahmed, Heba Mostafa, Ahmed, Rasha, Aigner, Elmar, Akarsu, Mesut, Akroush, Maisam, Akyuz, Umit, Al Mahtab, Mamun, Al Qadiri, Tahani, Al Rawahi, Yusriya, AL rubaee, Razzaq, Al Saffar, Muna, Alam, Shahinul, Al-Ani, Zaid, Albillos, Agustín, Alboraie, Mohamed, Al-Busafi, Said, Al-Emam, Mohamed, Alharthi, Jawaher, Ali, Kareem, Ali, Basma Abdelmoez, Ali, Mohammad, Ali, Raja Affendi Raja, Alisi, Anna, AL-Khafaji, Ali Raad, Alkhatry, Maryam, Aller, Rocio, Almansoury, Yahya, Al-Naamani, Khalid, Alnakeeb, Alaa, Alonso, Anna, Alqahtani, Saleh A., Alrabadi, Leina, Alswat, Khalid, Altaher, Mahir, Altamimi, Turki, Altamirano, Jose, Alvares-da-Silva, Mario R., Aly, Elsragy Adel M., Alzahaby, Amgad, Alzamzamy, Ahmed, Amano, Keisuke, Amer, Maysa A., Amin, Mona A., Amin, Sayed A., Amir, Ashraf A., Ampuero, Javier, Anas, Noha, Andreone, Pietro, Andriamandimby, Soa Fy, Anees, Mahmoud, Angela, Peltec, Antonios, Manal, Arafat, Wael, Araya, Jose Moreno, Armendariz-Borunda, Juan, Armstrong, Matthew J., Ashktorab, Hassan, Aspichueta, Patricia, Assal, Fathia, Atef, Mira, Attia, Dina, Atwa, Hoda, Awad, Reham, Awad, Mohyeldeen Abd Elaziz, Awny, Sally, Awolowo, Obafemi, Awuku, Yaw Asante, Ayada, Ibrahim, Aye, Than Than, Ayman, Sherif, Ayman, Hedy, Ayoub, Hesham, Azmy, Hosny M., Babaran, Romiro P., Badreldin, Omneya, Badry, Ahmed, Bahçecioğlu, İbrahim Halil, Bahour, Amira, Bai, Jiajia, Balaban, Yasemin, Balasubramanyam, Muthuswamy, Bamakhrama, Khaled, Banales, Jesus M, Bangaru, Babu, Bao, Jianfeng, Barahona, Jorge Suazo, Barakat, Salma, Barbalho, Sandra Maria, Barbra, Bikwa, Barranco, Beatriz, Barrera, Francisco, Baumann, Ulrich, Bazeed, Shamardan, Bech, Eva, Benayad, Aourarh, Benesic, Andreas, Bernstein, David, Bessone, Fernando, Birney, Susie, Bisseye, Cyrille, Blake, Martin, Bobat, Bilal, Bonfrate, Leonilde, Bordin, Dmitry S, Bosques-Padilla, Francisco, Boursier, Jerome, Boushab, Boushab Mohamed, Bowen, David, Bravo, Patricia Medina, Brennan, Paul N, Bright, Bisi, Broekaert, Ilse, Buque, Xabier, Burgos-Santamaría, Diego, Burman, Julio, Busetto, Luca, Byrne, Chris D., Cabral-Prodigalidad, Patricia Anne I., Cabrera-Alvarez, Guillermo, Cai, Wei, Cainelli, Francesca, Caliskan, Ali Riza, Canbay, Ali, Cano-Contreras, Ana, Cao, Hai-Xia, Cao, Zhujun, Carrion, Andres, Carubbi, Francesca, Casanovas, Teresa, Castellanos Fernández, Marlen Ivón, Chai, Jin, Chan, Siew Pheng, Charatcharoenwitthaya, Phunchai, Chavez-Tapia, Norberto, Chayama, Kazuaki, Chen, Jinjun, Chen, Lin, Chen, Zhong-Wei, Chen, Huiting, Chen, Sui-Dan, Chen, Qiang, Chen, Yaxi, Chen, Gang, Chen, En-Quang, Chen, Fei, Chen, Fei, Chen, Pei-Jer, Cheng, Robert, Cheng, Wendy, Chieh, Jack Tan Wei, Chokr, Imad, Cholongitas, Evangelos, Choudhury, Ashok, Chowdhury, Abhijit, Chukwudike, Evaristus Sunday, Ciardullo, Stefano, Clayton, Michelle, Clement, Karine, Cloa, Marie Michelle, Coccia, Cecilia, Collazos, Cristina, Colombo, Massimo, Cosar, Arif Mansur, Cotrim, Helma Pinchemel, Couillerot, Joris, Coulibaly, Alioune, Crespo, Gonzalo, Crespo, Javier, Cruells, Maria, Cua, Ian Homer Y., Dabbous, Hesham K., Dalekos, George N, D'Alia, Patricia, Dan, Li, Dao, Viet Hang, Darwish, Mostafa, Datz, Christian, Davalos-Moscol, Milagros B, Dawoud, Heba, de Careaga, Blanca Olaechea, de Knegt, Robert, de Ledinghen, Victor, de Silva, Janaka, Debzi, Nabil, Decraecker, Marie, Del Pozo, Elvira, Delgado, Teresa C, Delgado-Blanco, Manuel, Dembiński, Łukasz, Depina, Adilson, Derbala, Moutaz, Desalegn, Hailemichael, Desbois-Mouthon, Christèle, Desoky, Mahmoud, Dev, Anouk, Di Ciaula, Agostino, Diago, Moisés, Diallo, Ibrahima, Díaz, Luis Antonio, Dirchwolf, Melisa, Dongiovanni, Paola, Dorofeyev, Andrriy, Dou, Xiaoguang, Douglas, Mark W., Doulberis, Michael, Dovia, Cecil K., Doyle, Adam, Dragojević, Ivana, Drenth, Joost PH, Duan, Xuefei, Dulskas, Audrius, Dumitrascu, Dan L, Duncan, Oliver, Dusabejambo, Vincent, Dwawhi, Rev. Shem N.A., Eiketsu, Sho, El Amrousy, Doaa, El Deeb, Ahmed, El Deriny, Ghada, El Din, Hesham Salah, El Kamshishy, Salwa, El Kassas, Mohamed, El Raziky, Maissa, Elagamy, Osama A, Elakel, Wafaa, Elalfy, Dina, Elaraby, Hanaa, ElAwady, Heba, Elbadawy, Reda, Eldash, Hanaa Hassan, Eldefrawy, Manal S., Elecharri, Carol Lezama, Elfaramawy, Amel, Elfatih, Mohammed, Elfiky, Mahmoud, Elgamsy, Mohamed, Elgendy, Mohamed, El-Guindi, Mohamed A., Elhussieny, Nagi, Eliwa, Ahmed Maher, Elkabbany, Zeineb, El-Khayat, Hesham, El-Koofy, Nehal M., Elmetwalli, Alaa, Elrabat, Amr, El-Raey, Fathiya, Elrashdy, Fatma, Elsahhar, Medhat, Elsaid, Esraa M., Elsayed, Shimaa, Elsayed, Hany, Elsayed, Aly, Elsayed, Amr M., Elsayed, Hamdy, El-Serafy, Magdy, Elsharkawy, Ahmed M., Elsheemy, Reem Yehia, Elshemy, Eman Elsayed, Elsherbini, Sara, Eltoukhy, Naglaa, Elwakil, Reda, Emad, Ola, Emad, Shaimaa, Embabi, Mohamed, Ergenç, Ilkay, Ermolova, Tatiana, Esmat, Gamal, Esmat, Doaa M., Estupiñan, Enrique Carrera, Ettair, Said, Eugen, Tcaciuc, Ezz-Eldin, Mohammed, Falcón, Lidia Patricia Valdivieso, Fan, Yu-Chen, Fandari, Samah, Farag, Mahmoud, Farahat, Taghreed Mohamed, Fares, Eman M., Fares, Michael, Fassio, Eduardo, Fathy, Hayam, Fathy, Dina, Fathy, Wael, Fayed, Soheir, Feng, Dan, Feng, Gong, Fernández-Bermejo, Miguel, Ferreira, Cristina Targa, Ferrer, Javier Díaz, Forbes, Alastair, Fouad, Rabab, Fouad, Hanan M., Frisch, Tove, Fujii, Hideki, Fukunaga, Shuhei, Fukunishi, Shinya, Fulya, Hacer, Furuhashi, Masato, Gaber, Yasmine, Galang, Augusto Jose G., Gallardo, Jacqueline Cordova, Galloso, Rocío, Gamal, Mahmoud, Gamal, Reham, Gamal, Hadeel, Gan, Jian, Ganbold, Anar, Gao, Xin, Garas, George, Garba, Tony, García-Cortes, Miren, García-Monzón, Carmelo, García-Samaniego, Javier, Gastaldelli, Amalia, Gatica, Manuel, Gatley, Elizabeth, Gegeshidze, Tamar, Geng, Bin, Ghazinyan, Hasmik, Ghoneem, Salma, Giacomelli, Luca, Giannelli, Gianluigi, Giannini, Edoardo G., Giefer, Matthew, Ginès, Pere, Girala, Marcos, Giraudi, Pablo J, Goh, George Boon-Bee, Gomaa, Ahmed Ali, Gong, Benbingdi, Gonzales, Dina Hilda C., Gonzalez, Humberto C., Gonzalez-Huezo, Maria Saraí, Graupera, Isabel, Grgurevic, Ivica, Grønbæk, Henning, Gu, Xuelian, Guan, Lin, Gueye, Ibrahima, Guingané, Alice Nanelin, Gul, Ozen Oz, Gul, Cuma Bulent, Guo, Qing, Gupta, Pramendra Prasad, Gurakar, Ahmet, Gutierrez, Juan Carlos Restrepo, Habib, Ghada, Hafez, Azaa, Hagman, Emilia, Halawa, Eman, Hamdy, Osama, Hamed, Abd Elkhalek, Hamed, Dina H., Hamid, Saeed, Hamoudi, Waseem, Han, Yu, Haridy, James, Haridy, Hanan, Harris, David C H Harris, Hart, Michael, Hasan, Fuad, Hashim, Almoutaz, Hassan, Israa, Hassan, Ayman, Hassan, Essam Ali, Hassan, Adel Ahmed, Hassan, Magda Shehata, Hassanin, Fetouh, Hassnine, Alshymaa, Haukeland, John Willy, Hawal, Amr Ismael M., He, Jinfan, He, Qiong, He, Yong, He, Fang-Ping, Hegazy, Mona, Hegazy, Adham, Henegil, Osama, Hernández, Nelia, Hernández-Guerra, Manuel, Higuera-de-la-Tijera, Fatima, Hindy, Ibrahim, Hirota, Keisuke, Ho, Lee Chi, Hodge, Alexander, Hosny, Mohamed, Hou, Xin, Huang, Jiao-Feng, Huang, Yan, Huang, Zhifeng, Huang, Yuan, Huang, Ang, Huang, Yuan, Huang, Xiao-Ping, Hui-ping, Sheng, Hunyady, Bela, Hussein, Mennatallah A., Hussein, Osama, Hussien, Shahinaz Mahmoud, Ibáñez-Samaniego, Luis, Ibdah, Jamal, Ibrahim, Luqman, Ibrahim, Miada, Ibrahim, Ibrahim, Icaza-Chávez, Maria E., Idelbi, Sahar, Idilman, Ramazan Idilman, Ikeda, Mayumi, Indolfi, Giuseppe, Invernizzi, Federica, Irshad, Iram, Isa, Hasan Mohamed Ali, Iskandar, Natacha Jreige, Ismaiel, Abdulrahman, Ismail, Mariam, Ismail, Zulkifli, Ismail, Faisal, Iwamoto, Hideki, Jack, Kathryn, Jacob, Rachael, Jafarov, Fuad, Jafri, Wasim, Jahshan, Helen, Jalal, Prasun K, Jancoriene, Ligita, Janicko, Martin, Jayasena, Hiruni, Jefferies, Meryem, Jha, Vivekanand, Ji, Fanpu, Ji, Yaqiu, Jia, Jidong, Jiang, Changtao, Jiang, Ni, Jiang, Zong-zhe, Jin, Xing, Jin, Yi, Jing, Xu, Jingyu, Qian, Jinjolava, Maia, Jong, FX Himawan Haryanto, Jucov, Alina, Julius, Ibecheole, Kaddah, Mona, Kamada, Yoshihiro, kamal, Abobakr, Kamal, Enas Mohamed, Kamel, Ashraf Sayed, Kao, Jia-Horng, Karin, Maja, Karlas, Thomas, Kashwaa, Mohammad, Katsidzira, Leolin, Kaya, Eda, Kayasseh, M.Azzam, Keenan, Bernadette, Keklikkiran, Caglayan, Keml, William, Khalaf, Deia K., Khalefa, Rofida, Khamis, Sherin, Khater, Doaa, khattab, Hamed, Khavkin, Anatoly, Khlynova, Olga, Khmis, Nabil, Kobyliak, Nazarii, Koffas, Apostolos, Koike, Kazuhiko, Kok, Kenneth Y.Y., Koller, Tomas, Komas, Narcisse Patrice, Korochanskaya, Nataliya V., Koulla, Yannoula, Koya, Shunji, Kraft, Colleen, Kraja, Bledar, Krawczyk, Marcin, Kuchay, Mohammad Shafi, Kulkarni, Anand V, Kumar, Ashish, Kumar, Manoj, Lakoh, Sulaiman, Lam, Philip, Lan, Ling, Lange, Naomi F., Lankarani, Kamran Bagheri, Lanthier, Nicolas, Lapshyna, Kateryna, Lashen, Sameh A., Laure, Konang Nguieguia Justine, Lazebnik, Leonid, Lebrec, Didier, Lee, Samuel S., Lee, Way Seah, Lee, Yeong Yeh, Leeming, Diana Julie, Leite, Nathalie Carvalho, Leon, Roberto, Lesmana, Cosmas Rinaldi Adithya, Li, Junfeng, Li, Qiong, Li, Jun, Li, Yang-Yang, Li, Yufang, Li, Lei, Li, Min, li, Yiling, Liang, Huiqing, Lijuan, Tang, Lim, Seng Gee, Lim, Lee-Ling, Lin, Shumei, Lin, Han-Chieh, Lin, Rita, Lithy, Rania, Liu, Yaru, Liu, Yuanyuan, Liu, Xin, Liu, Wen-Yue, Liu, Shourong, Liu, Ken, Liu, Tian, Lonardo, Amedeo, López, Mariana Bravo, López-Benages, Eva, Lopez-Jaramillo, Patricio, Lu, Huimin, Lu, Lun Gen, Lu, Yan, Lubel, John, Lui, Rashid, Lupasco, Iulianna, Luzina, Elena, Lv, Xiao-Hui, Lynch, Kate, Ma, Hong-Lei, Machado, Mariana Verdelho, Maduka, Nonso, Madzharova, Katerina, Magdaong, Russellini, Mahadeva, Sanjiv, Mahfouz, Amel, Mahmood, Nik Ritza Kosai Nik, Mahmoud, Eman, Mahrous, Mohamed, Maiwall, Rakhi, Majeed, Ammar, Majumdar, Avik, Mak, Loey, Maklouf, Madiha M, Malekzadeh, Reza, Mandato, Claudia, Mangia, Alessandra, Mann, Jake, Mansour, Hala Hussien, Mansouri, Abdellah, Mantovani, Alessandro, Mao, Jun qian, Maramag, Flor, Marchesini, Giulio, Marcus, Claude, Marinho, Rui António Rocha Tato, Martinez-Chantar, Maria L, Martins, Antonieta A. Soares, Marwan, Rana, Mason, Karen Frances, Masoud, Ghadeer, Massoud, Mohamed Naguib, Matamoros, Maria Amalia, Mateos, Rosa Martín, Mawed, Asmaa, Mbanya, Jean Claude, Mbendi, Charles, McColaugh, Lone, McLeod, Duncan, Medina, Juan Francisco Rivera, Megahed, Ahmed, Mehrez, Mai, Memon, Iqbal, Merat, Shahin, Mercado, Randy, Mesbah, Ahmed, Meskini, Taoufik, Metwally, Mayada, Metwaly, Rasha, Miao, Lei, Micah, Eileen, Miele, Luca, Milivojevic, Vladimir, Milovanovic, Tamara, Mina, Yvonne L., Mishkovik, Milan, Mishriki, Amal, Mitchell, Tim, Mohamed, Alshaimaa, Mohamed, Mona, Mohamed, Sofain, Mohammed, Shady, Mohammed, Ahmed, Mohan, Viswanathan, Mohie, Sara, Mokhtar, Aalaa, Moniem, Reham, Montilla, Mabel Segura, Morales, Jose Antonio Orozco, Morata, María María Sánchez, Moreno-Planas, Jose Maria, Morise, Silvia, Mosaad, Sherif, Moselhy, Mohamed, Mostafa, Alaa Mohamed, Mostafa, Ebraheem, Mouane, Nezha, Mousa, Nasser, Moustafa, Hamdy Mahfouz, Msherif, Abeer, Muller, Kate, Munoz, Christopher, Muñoz-Urribarri, Ana Beatriz, Murillo, Omar Alfaro, Mustapha, Feisul Idzwan, Muzurović, Emir, Nabil, Yehia, Nafady, Shaymaa, Nagamatsu, Ayu, Nakajima, Atsushi, Nakano, Dan, Nan, Yuemin, Nascimbeni, Fabio, Naseef, Mirella S., Nashat, Nagwa, Natalia, Taran, Negro, Francesco, Nersesov, Alexander V., Neuman, Manuela, Ng'wanasayi, Masolwa, Ni, Yan, Nicoll, Amanda, Niizeki, Takashi, Nikolova, Dafina, Ningning, Wang, Niriella, Madunil, Nogoibaeva, K.A, Nordien, Rozeena, O Sullivan, Catherine, O'Beirne, James, Obekpa, Solomon, Ocama, Ponsiano, Ochwoto, Missiani, Ogolodom, Michael Promise, Ojo, Olusegun, Okrostsvaridze, Nana, Oliveira, Claudia P., Omaña, Raul Contreras, Omar, Omneya M., Omar, Hanaa, Omar, Mabroka, Omran, Salma, Omran, Reham, Osman, Marian Muse, Owise, Nevin, Owusu-Ansah, Theobald, Padilla- Machaca, P. Martín, Palle, Sirish, Pan, Ziyan, Pan, Xiao-Yan, Pan, Qiuwei, Papaefthymiou, Apostolis, Paquissi, Feliciano Chanana, Par, Gabriella, Parkash, Arit, Payawal, Diana, Peltekian, Kevork M., Peng, Xuebin, Peng, Liang, Peng, Ying, Pengoria, Rahul, Perez, Martina, Pérez, José Luis, Pérez, Norma Marlene, Persico, Marcello, Pessoa, Mário Guimarães, Petta, Salvatore, Philip, Mathew, Plaz Torres, Maria Corina, Polavarapu, Naveen, Poniachik, Jaime, Portincasa, Piero, Pu, Chunwen, Pürnak, Tuğrul, Purwanto, Edhie, Qi, Xiaolong, Qi, Xingshun, Qian, Zibing, Qiang, Zhao, Qiao, Zengpei, Qiao, Liang, Queiroz, Alberto, Rabiee, Atoosa, Radwan, Manal, Rahetilahy, Alain Marcel, Ramadan, Yasmin, Ramadan, Dina, Ramli, Anis Safura, Ramm, Grant A., Ran, Ao, Rankovic, Ivan, RAO, Huiying, Raouf, Sara, Ray, Sayantan, Reau, Nancy, Refaat, Ahmed, Reiberger, Thomas, Remes-Troche, Jose M, Reyes, Eira Cerda, Richardson, Ben, Ridruejo, Ezequiel, Riestra Jimenez, Sergio, Rizk, Ibrahim, Roberts, Stuart, Roblero, Juan Pablo, Robles, Jorge Alberto Prado, Rockey, Don, Rodríguez, Manuel, Rodríguez Hernández, Heriberto, Román, Eva, Romeiro, Fernando Gomes, Romeo, Stefano, Rosales-Zabal, Jose Miguel, Roshdi, Georgina R., Rosso, Natalia, Ruf, Andres, Ruiz, Patricia Cordero, Runes, Nelia R., Ruzzenente, Andrea, Ryan, Marno, Saad, Ahmed, Sabbagh, Eman BE, Sabbah, Meriam, Saber, Shimaa, Sabrey, Reham, Sabry, Ramy, Saeed, Maysaa Abdallah, Said, Dina, Said, Ebada M, Sakr, Mohammad Amin, Salah, Yara, Salama, Rabab Maamoun, Salama, Asmaa, Saleh, Hussein, Saleh, Ahmed, Salem, Ahmed, Salem, Ahmed Thabet, Salifou, Alkassoum, Salih, Aso Faeq, Salman, Abdallah, Samouda, Hanen, Sanai, Faisal, Sánchez-Ávila, Juan Francisco, Sanker, Lakshumanan, Sano, Tomoya, Sanz, Miquel, Saparbu, Tobokalova, Sawhney, Rohit, Sayed, Fatma, Sayed, Sayed A., Sayed, Ashraf Othman, Sayed, Manar, Sebastiani, Giada, Secadas, Laura, Sediqi, Khawaja Qamaruddin, Seif, Sameh, Semida, Nady, Şenateş, Ebubekir, Serban, Elena Daniela, Serfaty, Lawrence, Seto, Wai-Kay, Sghaier, Ikram, Sha, Min, Shabaan, Hamada M., Shalaby, Lobna, Shaltout, Inass, Sharara, Ala I., Sharma, Vishal, Shawa, Isaac Thom, Shawkat, Ahmed, Shawky, Nehal, Shehata, Osama, Sheils, Sinead, Shewaye, Abate Bane, Shi, Guojun, Shi, Junping, Shimose, Shigeo, Shirono, Tomotake, Shou, Lan, Shrestha, Ananta, Shui, Guanghou, Sievert, William, Sigurdardottir, Solveig, Sira, Mostafa Mohamed, Siradj, Riyadh, Sison, Cecilia, Smyth, Linda, Soliman, Reham, Sollano, Jose D, Sombie, Roger, Sonderup, Mark, Sood, Siddharth, Soriano, German, Stedman, Catherine A M, Stefanyuk, Oksana, Štimac, Davor, Strasser, Simone, Strnad, Pavel, Stuart, Katherine, Su, Wen, Su, Minghua, Sumida, Yoshio, Sumie, Shuji, Sun, Dan-Qin, Sun, Jing, Suzuki, Hiroyuki, Svegliati-Baroni, Gianluca, Swar, Mohamed Osman, TAHARBOUCHT, S., Taher, Zenab, Takamura, Saori, Tan, Lin, Tan, Soek-Siam, Tanwandee, Tawesak, Tarek, Sara, Tatiana, Ghelimici, Tavaglione, Federica, Tecson, Gina Y., Tee, Hoi-Poh, Teschke, Rolf, Tharwat, Mostafa, Thong, Vo Duy, Thursz, Mark, Tine, Tulari, Tiribelli, Claudio, Tolmane, Ieva, Tong, Jing, Tongo, Marco, Torkie, Mamdouh, Torre, Aldo, Torres, Esther A, Trajkovska, Meri, Treeprasertsuk, Sombat, Tsutsumi, Tsubasa, Tu, Thomas, Tur, Josep A., Turan, Dilara, Turcan, Svetlana, Turkina, Svetlana, Tutar, Engin, Tzeuton, Christian, Ugiagbe, Rose, Uygun, Ahmet, Vacca, Michele, Vajro, Pietro, Van der Poorten, David, Van Kleef, Laurens A., Vashakidze, Eliza, Velazquez, Carlos Moctezuma, Velazquez, Mirtha Infante, Vento, Sandro, Verhoeven, Veronique, Vespasiani-Gentilucci, Umberto, Vethakkan, Shireene Ratna, Vilaseca, Josep, Vítek, Libor, Volkanovska, Ance, Wallace, Michael, Wan, Wang, Wang, Yan, Wang, Ying, Wang, Xiaolin, Wang, Xuemei, Wang, Chengyan, Wang, Chunjiong, Wang, Mingjie, Wangchuk, Pelden, Weltman, Martin, White, MaryFrances, Wiegand, Johannes, Wifi, Mohamed-Naguib, Wigg, Alan, Wilhelmi, Markus, William, Remon, Wittenburg, Henning, Wu, Shengjie, Wubeneh, Abdu Mohammed, Xia, Hongping, Xiao, Jian, Xiao, Xiao, Xiaofeng, Wang, Xiong, Wanyuan, Xu, Liang, Xu, Jie, Xu, Weiguo, Xu, Jing-Hang, Xu, Keshu, Xu, Yumin, Xu, Shi-Hao, Xu, Meng, Xu, Aimin, Xu, Chengfu, Yan, Hongmei, Yang, Jingyi, Yang, Rui-Xu, Yang, Yating, Yang, Qinhe, Yang, Naibin, Yao, Jia, Yara, Justine, Yaraş, Serkan, Yılmaz, Nimet, Younes, Ramy, younes, Huda, Young, Sona, Youssef, Farah, Yu, Yanyan, Yu, Ming-Lung, Yuan, Jing, Yue, Zhang, Yuen, Man-Fung, Yun, Wang, Yurukova, Nonka, Zakaria, Serag, Zaky, Samy, Zaldastanishvili, Maia, Zapata, Rodrigo, Zare, Nazanin, Zerem, Enver, Zeriban, Nema, Zeshuai, Xu, Zhang, Huijie, Zhang, Xuemei, Zhang, Yupei, Zhang, Wen-Hua, Zhang, Xuchen, Zhang, Yon-ping, Zhang, Yuexin, Zhang, Zhan-qing, Zhao, Jingmin, Zhao, Rong-Rong, Zhao, Hongwei, Zheng, Chao, Zheng, Yijie, Zheng, Ruidan, Zheng, Tian-Lei, Zheng, Kenneth, Zhou, Xi Qiao, Zhou, Yongjian, Zhou, Yu-Jie, Zhou, Hong, Zhou, Ling, Zhou, Yongning, Zhu, Long dong, Zhu, Yong Fen, Zhu, Yueyong, Zhu, Pei-Wu, Ziada, Ebtesam, Ziring, David, Ziyi, Li, Zou, Shanshan, Zou, Zhengsheng, Zou, Huaibin, and Zuart Ruiz, Roberto

Published
2022
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31. Predictores de riesgo en una cohorte española con cardiolaminopatías. Registro REDLAMINA

Author

Barriales-Villa, Roberto, Ochoa, Juan P., Larrañaga-Moreira, José M., Salazar-Mendiguchía, Joel, Díez-López, Carles, Restrepo-Córdoba, María Alejandra, Álvarez-Rubio, Jorge, Robles-Mezcua, Ainhoa, Olmo-Conesa, María C., Nicolás-Rocamora, Elisa, Sanz, Jorge, Villacorta, Eduardo, Gallego-Delgado, María, Yotti, Raquel, Espinosa, María Ángeles, Manovel, Ana, Rincón-Díaz, Luis M., Jiménez-Jaimez, Juan, Bermúdez-Jiménez, Francisco J., Basurte-Elorz, M. Teresa, Climent-Payá, Vicente, García-Álvarez, María I., Rodríguez-Palomares, José Fernando, Limeres-Freire, Javier, Pérez-Guerrero, Ainhoa, Cantero-Pérez, Eva M., Peña-Peña, María L., Palomino-Doza, Julián, Crespo-Leiro, María G., García-Pinilla, José M., Zorio, Esther, Ripoll-Vera, Tomás, García-Pavía, Pablo, Ortiz-Genga, Martín, and Monserrat, Lorenzo

Abstract

Según las guías de muerte súbita, se debe considerar un desfibrilador automático implantable (DAI) para los pacientes con miocardiopatía dilatada debida a variantes en el gen de la lamina (LMNA)con al menos 2 factores: varones, fracción de eyección del ventrículo izquierdo (FEVI) <45%, taquicardia ventricular no sostenida (TVNS) y variantes no missense. Nuestro objetivo es describir las características clínicas de una cohorte española de pacientes con cardiolaminopatías (registro REDLAMINA) y evaluar los criterios de riesgo vigentes.

Published
2021
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32. Falls Predict Acute Hospitalization in Parkinson’s Disease

Author

Santos García, Diego, de Deus Fonticoba, Teresa, Cores, Carlos, Castro, Ester Suárez, Hernández Vara, Jorge, Jesús, Silvia, Mir, Pablo, Cosgaya, Marina, Martí, Maria José, Pastor, Pau, Cabo, Iria, Seijo, Manuel, Legarda, Inés, Vives, Bárbara, Caballol, Nuria, Rúiz Martínez, Javier, Croitoru, Ioana, Cubo, Esther, Miranda, Javier, Alonso Losada, Maria Gema, Labandeira, Carmen, López Ariztegui, Nuria, Morales-Casado, Mabel, González Aramburu, Isabel, Infante, Jon, Escalante, Sonia, Bernardo, Noemí, Blázquez Estrada, Marta, Menéndez González, Manuel, Caldentey, Juan García, Borrué, Carmen, Vela, Lydia, Catalán, Maria José, Gómez Mayordomo, Víctor, Kurtis, Mónica, Prieto, Cristina, Ordás, Carlos, Nogueira, Víctor, López Manzanares, Lydia, Ávila Rivera, Maria Asunción, Puente, Victor, García Moreno, Jose Manuel, Solano Vila, Berta, Álvarez Sauco, María, Carrillo Padilla, Francisco, Carlos Martínez Castrillo, Juan, Sánchez Alonso, Pilar, Gastón, Itziar, Kulisevsky, Jaime, Valero, Caridad, de Fábregues, Oriol, González Ardura, Jessica, López Díaz, Luis Manuel, and Martinez-Martin, Pablo

Abstract

There is a need for identifying risk factors for hospitalization in Parkinson’s disease (PD) and also interventions to reduce acute hospital admission. To analyze the frequency, causes, and predictors of acute hospitalization (AH) in PD patients from a Spanish cohort. PD patients recruited from 35 centers of Spain from the COPPADIS-2015 (COhort of Patients with PArkinson’s DIsease in Spain, 2015) cohort from January 2016 to November 2017, were included in the study. In order to identify predictors of AH, Kaplan-Meier estimates of factors considered as potential predictors were obtained and Cox regression performed on time to hospital encounter 1-year after the baseline visit. Thirty-five out of 605 (5.8%) PD patients (62.5±8.9 years old; 59.8% males) presented an AH during the 1-year follow-up after the baseline visit. Traumatic falls represented the most frequent cause of admission, being 23.7% of all acute hospitalizations. To suffer from motor fluctuations (HR [hazard ratio] 2.461; 95% CI, 1.065–5.678; p= 0.035), a very severe non-motor symptoms burden (HR [hazard ratio] 2.828; 95% CI, 1.319–6.063; p = 0.008), falls (HR 3.966; 95% CI 1.757–8.470; p= 0.001), and dysphagia (HR 2.356; 95% CI 1.124–4.941; p= 0.023) was associated with AH after adjustment to age, gender, disease duration, levodopa equivalent daily dose, total number of non-antiparkinsonian drugs, and UPDRS-IIIOFF. Of the previous variables, only falls (HR 2.998; 95% CI 1.080–8.322; p= 0.035) was an independent predictor of AH. Falls is an independent predictor of AH in PD patients.

Published
2021
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33. Neurofobia: frecuencia y descripción de factores relacionados en una universidad Latinoamericana en 2019

Author

Díaz, Luis, Velásquez, Jean, and Pérez, Gabriel

Abstract

La neurofobia es el miedo a la práctica de la neurología clínica. Puede contribuir a que los estudiantes de pregrado obtengan peores calificaciones, empeora el manejo de pacientes neurológicos por médicos no especialistas, y contribuye a la disminución del número de neurólogos. Los datos sobre su frecuencia y factores relacionados con su aparición en alumnos latinoamericanos son limitados.

Published
2020
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35. Tumores ginecológicos en pacientes portadoras de mutación BRCA1 y BRCA2

Author

Oliver Pérez, Reyes, de Miguel Reyes, Montserrat, Robles Díaz, Luis, Vivares López, Almudena, Baeza Hernández, Gloria, Ferrández, Consuelo Sanz, Arroyo Vozmediano, M. Luisa, Gallego Álvarez, Marta, Blanco Guerrero, Marta, García Chapinal, Beatriz, Hernández Muñoz, Irene, and Aragón Sánchez, Sofía

Abstract

Analizar la incidencia de cáncer de mama y de ovario, y las características de dichos tumores en pacientes portadoras de mutaciones BRCA1-2.

Published
2020
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37. Relación entre el tipo de arco de sonrisa y el biotipo facial en jóvenes peruanos.

Author

Gamarra-Díaz, Luis Gustavo, Chonlón-Eilleen, Cachay, and Rojas-Padilla, Sandra

Abstract

Copyright of Revista Oral is the property of Benemerita Universidad Autonoma de Puebla and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019

38. O-20 EFFECTS OF ISOCALORIC AND NEGATIVE CALORIE BALANCE EXERCISE ON SERUM LEVELS OF INSULIN-LIKE GROWTH FACTOR TYPE 1 IN SUBJECTS WITH INITIAL AND ADVANCED FATTY LIVER

Author

Fuenzalida, María Jesús, Barrera, Francisco, Mies, Hermann, Correa, Valeria, Allendes, Francisca, Solis, Nancy, Oyarzún, Vanessa, Díaz, Luis Antonio, Arrese, Marco, Arab, Juan Pablo, Cabrera, Daniel, Contreras, Felipe, Riquelme, Santiago, Ferreccio, Catterina, Huidobro, Laura Andrea, De Los Ángeles Spencer, María, Garrido, Macarena, Loyola, Jennifer, Correa, Paola, Sobarzo, Felipe, Silva, Paula, Herrera, Cristian, and Godoy, Franco

Abstract

Insulin-like growth factor 1 (IGF-1) is a hepatokine that has a protective effect on fatty liver. Previous studies in healthy subjects suggest that isocaloric exercise (with neutral caloric balance) would increase serum levels of IGF-1. This study aimed to evaluate the effect of moderate isocaloric exercise (ICBE) and negative caloric balance exercise (NCBE) on serum levels of IGF-1 in subjects with initial and advanced (F3-4) MAFLD (Metabolic Associated Fatty Liver Disease).

Published
2024
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39. P-19 CHARACTERIZATION, PROGNOSTIC FACTORS, AND SURVIVAL IN MODERATE ALCOHOL-ASSOCIATED HEPATITIS: A MULTICENTER STUDY

Author

Idalsoaga, Francisco, Díaz, Luis Antonio, Corsi, Oscar, Ayares, Gustavo, Arnold, Jorge, Dunn, Winston, Li, Yanming, Singal, Ashwani, Simonetto, Doug, Ayala-Valverde, María, Ramirez, Carolina A., Morales-Arraez, Dalia, Zhang, Wei, Qian, Steve, Ahn, Joseph, Buryska, Seth, Mehta, Heer, Waleed, Muhammad, Stefanescu, Horia, Horhat, Adelina, Bumbu, Andreea, Attar, Bashar, Agrawal, Rohit, Cabezas, Joaquín, Cuyàs, Berta, Poca, Maria, Pastor, German Soriano, Sarin, Shiv K, Maiwall, Rakhi, Jalal, Prasun K, Tijera, María Fátima Higuera-De La, Kulkarni, Anand, Rao, Nagaraja, Salazar, Patricia Guerra, Skladaný, Lubomir, Bystrianska, Natália, Prado, Veronica, Clemente-Sanchez, Ana, Rincón, Diego, Haider, Tehseen, Chacko, Kristina R, Romero, Gustavo A, Pollarsky, Florencia D, Restrepo, Juan Carlos, Toro, Luis G, Yaquich, Pamela, Mendizabal, Manuel, Garrido, Maria Laura, Marciano, Sebastian, Dirchwolf, Melisa, Vargas, Victor, Jimenez, Cesar, García-Tsao, Guadalupe, Ortiz, Guillermo, Abraldes, Juan G, Kamath, Patrick, Shah, Vijay, Bataller, Ramon, and Arab, Juan Pablo

Abstract

Alcohol-associated hepatitis (AH) corresponds to a severe entity with high short-term mortality; however, few studies have been published in patients with moderate AH. This study aimed to characterize patients with moderate AH in a global study, identifying prognostic factors and survival at 30, 90, and 180 days.

Published
2024
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40. O-13 SUB-OPTIMAL GLOBAL PUBLIC HEALTH POLICIES AND STRATEGIES TO TACKLE HEPATOCELLULAR CARCINOMA

Author

Díaz, Luis Antonio, Fuentes, Eduardo, Norero, Blanca, Corsi, Oscar, Ayares, Gustavo, Idalsoaga, Francisco, Pizarro, Gonzalo, García, Sergio, Vázquez, Valeria, Lacalle, Lucas, Arnold, Jorge, Lazo, Mariana, Ferreccio, Catterina, Mendizabal, Manuel, Piñero, Federico, Marín, Juan Ignacio, Addissie, Benyam, Ijeoma, Ifeorah, Louvet, Alexandre, Piano, Salvatore, Pinto, Helena Cortez-, Wong, Vincent, Kulkarni, Anand V., Cotter, Thomas G., Brahmania, Mayur, Dunn, Winston, Kamath, Patrick S., Singal, Ashwani K., Debes, José, Reig, María, Loomba, Rohit, Bataller, Ramón, Lazarus, Jeffrey V., Arrese, Marco, and Arab, Juan Pablo

Abstract

Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide. We aimed to explore HCC-related population-wide public health policies (PHP) worldwide.

Published
2024
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41. P-10 THE EFFECTS OF CHILEAN RESPONSE TO COVID-19 ON ALCOHOL CONSUMERS: A NATURAL POLICY EXPERIMENT

Author

Fuenzalida, María Jesús, Corsi, Óscar, Cox, Valentina, Díaz, Luis Antonio, Arab, Juan Pablo, Margozzini, Paula, and Marín, José

Abstract

Alcohol consumption is a leading public health challenge in Chile. The country's response to COVID-19 was an exceptional simulation of the WHO´s SAFER initiative to reduce alcohol-related harm. We hypothesize that policies to control COVID-19 affected alcohol consumption in Chile. This study aimed to analyze the Chilean prevalence of alcohol consumption during the COVID-19 pandemic.

Published
2024
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42. O-6 EXPLORING THE IMPACT OF INFECTIONS IN PATIENTS WITH ALCOHOL- ASSOCIATED HEPATITIS IN LATIN AMERICA

Author

Díaz, Luis Antonio, Idalsoaga, Francisco, Ayares, Gustavo, Arnold, Jorge, Maldonado, Katherine, Ayala, María, Perez, Diego, Gomez, Jaime, Escarate, Rodrigo, Fuentes, Eduardo, Roblero, Juan Pablo, Norero, Blanca, Lazarte, Raul, Velarde, José Antonio, Jacobo, Janett, Córdova, Jacqueline, Higuera-de-la-Tijera, Fátima, Varela, Jesús, Mejía, Scherezada, Silva, Rita, Melo, Cristina, Araujo, Roberta C., Pereira, Gustavo Henrique, Couto, Claudia, Bessone, Fernando, Tanno, Mario, Romero, Gustavo, Mendizabal, Manuel, Marciano, Sebastián, Gomez, Gonzalo, Dirchwolf, Melisa, Montes, Pedro, Guerra, Patricia, Ramos, Geraldine, Restrepo, Juan Carlos, Carrera, Enrique, Brahmania, Mayur, Singal, Ashwani, Bataller, Ramón, Shah, Vijay, Kamath, Patrick S., Arrese, Marco, and Arab, Juan Pablo

Abstract

Severe alcohol-associated hepatitis (AH) is frequently associated with higher infection risk. This study aimed to assess the impact of infections in patients with AH in a multinational cohort in Latin America.

Published
2024
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43. O- 23 STRATEGIES TO ELIMINATE HEPATITIS C VIRUS INFECTION IN THE AMERICAS

Author

Díaz, Luis Antonio, García, Sergio, Khan, Rayan, Ayares, Gustavo, Uribe, Javier, Idalsoaga, Francisco, Fuentealba, José Miguel, Fuentes, Eduardo, Maldonado, Katherine, Lazo, Mariana, Ferreccio, Catterina, Mendizabal, Manuel, Dirchwolf, Melisa, Guerra, Patricia, Oliveira, Claudia P., Guimarães, Mario, Reis, Mario, Sebastiani, Giada, Brahmania, Mayur, Ramji, Alnoor, Niazi, Mina, Ko, Hin Hin, Feld, Jordan, Restrepo, Juan Carlos, Ramírez, Wagner, Alfaro, Omar, Castellanos-Fernández, Marlen, Carrera, Enrique, Ayala, José Roberto Aguirre, Sánchez, Abel, Sánchez, Marco, Andara, María Teresa, Castro, Graciela, Chavez-Tapia, Norberto, Mendez-Sanchez, Nahum, Adames, Enrique, Lombardo, Julissa, Girala, Marcos, Morán, Elías, Padilla-Machaca, Martin, Díaz, Javier, Tagle, Martín, Mainardi, Victoria, Hernandez, Nelia, Martínez, Edmundo, Alvarado-Tapias, Edilmar, Leon, Roberto, Talal, Andrew, Thomas, Emmanuel, Springer, Sandra, Garcia-Saenz-de-Sicilia, Mauricio, Zhang, Wei, Bajaj, Jasmohan, Tapper, Elliot B., Izzy, Manhal J., Gish, Robert G., Attar, Bashar, Cotter, Thomas G., Lucey, Michael R., Kamath, Patrick S., Singal, Ashwani K., Bataller, Ramón, Mezzano, Gabriel, Soza, Alejandro, Lazarus, Jeffrey V., Arrese, Marco, and Arab, Juan Pablo

Abstract

Although the WHO strategy aims to eliminate the hepatitis C virus (HCV) as a public health threat by 2030, national strategies are variable worldwide. This study aimed to assess the establishment of different policies and strategies to eliminate HCV in the Americas.

Published
2024
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44. Resultados clínicos y radiológicos del vástago SL-Plus con un seguimiento mínimo de 10 años: un estudio retrospectivo

Author

Palacios-Díaz, Luis, Fernández-Fernández, Ricardo, Sánchez, Alberto Losa, and Cruz-Pardos, Ana

Abstract

Objetivo: El vástago cementado SL-Plus fue introducido en 1993 como una evolución del vástago Alloclassic con algunas modificaciones. El objetivo es describir los resultados clínicos y radiográficos del vástago SL-Plus en una serie de casos con un seguimiento mínimo de 10 años.

Published
2024
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45. Alcohol-related liver disease: A global perspective

Author

Narro, Graciela Elia Castro, Díaz, Luis Antonio, Ortega, Eric Kauffman, Garín, María Fernanda Bautista, Reyes, Eira Cerda, Delfin, Pindaro Sebastian Martinez, Arab, Juan Pablo, and Bataller, Ramón

Abstract

Alcohol-associated liver disease (ALD) represents one of the deadliest yet preventable consequences of excessive alcohol use. It represents 5.1 % of the global burden of disease, mainly involving the productive-age population (15-44 years) and leading to an increased mortality risk from traffic road injuries, suicide, violence, cardiovascular disease, neoplasms, and liver disease, among others, accounting for 5.3 % of global deaths. Daily alcohol consumption, binge drinking (BD), and heavy episodic drinking (HED) are the patterns associated with a higher risk of developing ALD. The escalating global burden of ALD, even exceeding what was predicted, is the result of a complex interaction between the lack of public policies that regulate alcohol consumption, low awareness of the scope of the disease, late referral to specialists, underuse of available medications, insufficient funds allocated to ALD research, and non-predictable events such as the COVID-19 pandemic, where increases of up to 477 % in online alcohol sales were registered in the United States. Early diagnosis, referral, and treatment are pivotal to achieving the therapeutic goal in patients with alcohol use disorder (AUD) and ALD, where complete alcohol abstinence and prevention of alcohol relapse are expected to enhance overall survival. This can be achieved through a combination of cognitive behavioral, motivational enhancement and pharmacological therapy. Furthermore, the appropriate use of available pharmacological therapy and implementation of public policies that comprehensively address this disease will make a real difference.

Published
2024
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46. The burden of liver disease in Latin America

Author

Díaz, Luis Antonio, Villota-Rivas, Marcela, Barrera, Francisco, Lazarus, Jeffrey V., and Arrese, Marco

Abstract

Liver disease poses a substantial burden in Latin America. This burden is primarily attributed to a high level of alcohol consumption and the increasing prevalence of risk factors associated with metabolic dysfunction-associated steatotic liver disease (MASLD), such as sedentary lifestyles, easy access to ultra-processed foods, obesity, and type 2 diabetes mellitus. These epidemiological trends are cause for concern, especially considering that there are significant challenges in addressing them, due to disparities in access to liver disease screening and care. In this article, we aim to provide an overview of the current situation regarding liver disease in Latin America. We also discuss recent multinational proposals designed to address the growing MASLD burden via its integration into existing non-communicable diseases policies, at both local and global levels. Additionally, we emphasize the urgent need to establish effective public health policies that target both MASLD risk factors and excessive alcohol consumption. Furthermore, we discuss the development of liver transplantation programs, areas for improvement in medical education and research capabilities, and how the fostering of extensive collaboration among all stakeholders is crucial for addressing liver disease in the region.

Published
2024
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49. Finite elements analysis of an underground collector installed by pipe-jacking method.

Author

Díaz-Díaz, Luis María, Omer, Joshua, and Arias, Daniel

Abstract

Using the commercial software RS2, a 2D finite-element program for soil and rock application, the ground response to pipe jacking in pipeline installation in Avilés (north coast of Spain) was analysed. The geology of the location comprises Quaternary deposits on both flanks of the Avilés estuary and includes different highly variable geotechnical behaviour. Both axisymmetric and plane strain analyses were carried out inRS2to simulate in 3D the ground response to pipe advancement. The results demonstrate that the vertical displacements at specific positions in the immediate vicinity of the pipeline were small. The maximum deformation at ground surface was shown to be less than 1.5 mm, which was still safe. However, the displacements were found to vary depending on the local properties of the materials drilled. Stress distributions were also computed. [ABSTRACT FROM PUBLISHER]

Published
2018
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50. Systemic Ozone Therapy by Rectal Insufflation for Immunoglobulin A Deficiency.

Author

Díaz-Luis, Jacqueline, Menéndez-Cepero, Silvia, Macías-Abraham, Consuelo, and Fariñas-Rodríguez, Lucía

Subjects
THERAPEUTIC use of antioxidants, OZONE therapy, RECTUM, ACADEMIC medical centers, BIOMARKERS, IMMUNOGLOBULINS, IMMUNOLOGIC diseases, OZONE, OXIDATIVE stress, CONTROL groups, INSUFFLATION, DATA analysis software, DESCRIPTIVE statistics, ANATOMY
Abstract

INTRODUCTION IgA deficiency is a primary immunodeficiency predominantly due to an antibody defect, for which there is no replacement therapy. Treatment consists of prevention and treatment of infections and other associated conditions. Given the immunomodulatory and regulatory properties of the redox balance of ozone therapy in infectious and inflammatory conditions, evaluation of its effect on IgA deficiency is of interest. OBJECTIVE Assess the benefits and possible adverse effects of ozone treatment in patients with IgA deficiency. METHODS A mono centric randomized controlled phase 2 clinical trial (RPCEC 00000236) was carried out, after approval by the Institutional Ethics Committee of the Roberto Rodríguez Fernández Provincial General Teaching Hospital in Morón, Ciego de Ávila Province, Cuba. Included were 40 patients aged 5–50 years, distributed in 2 groups of 20, after agreeing to participate and signing informed consent. The experimental group received 2 cycles of ozone by rectal insufflation for 20 days (5 times a week for 4 weeks each cycle) with a 3-month interval between cycles, for a total of 40 doses, with age-adjusted dose ranges. The control group was treated with leukocyte transfer factor (Hebertrans), 1 U per m2 of body surface area subcutaneously, once weekly for 12 weeks. Frequency of appearance and severity of clinical symptoms and signs of associated diseases, serum immunoglobulin concentrations and balance of pro-oxidant and antioxidant biomarkers were recorded at treatment initiation and one month after treatment completion. Therapeutic response was defined as complete, partial, stable disease or progressive disease. Descriptive statistics and significance were calculated to compare groups and assess effect size. RESULTS One month after treatment completion, 70% of patients in the experimental group experienced significant increases in IgG (p = 0.000) and IgM (p = 0.033). The experimental group also displayed decreased pro-oxidation biomarkers, glutathione modulation and increased antioxidant enzymes, with reduced oxidative stress; none of these occurred in the control group. Complete therapeutic response was achieved in 85% of patients in the experimental group and only 45% in the control group. Mild, transient adverse events were reported in both groups. CONCLUSIONS Ozone therapy by rectal insufflation is a suitable therapeutic option for treating IgA deficiency because it produces antioxidant and immunomodulatory effects and is feasible, safe and minimally invasive. [ABSTRACT FROM AUTHOR]

Published
2018
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