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2. The 2024 American Association for Thoracic Surgery expert consensus document: Current standards in donor lung procurement and preservation.

Author

Kukreja, Jasleen, Campo-Canaveral de la Cruz, Jose Luis, Van Raemdonck, Dirk, Cantu, Edward, Date, Hiroshi, D'Ovidio, Frank, Hartwig, Matthew, Klapper, Jacob A., Kelly, Rosemary F., Lindstedt, Sandra, Rosso, Lorenzo, Schaheen, Lara, Smith, Michael, Whitson, Bryan, Saddoughi, Sahar A., and Cypel, Marcelo

Abstract

Donor lung procurement and preservation is critical for lung transplantation success. Unfortunately, the large variability in techniques impacts organ utilization rates and transplantation outcomes. Compounding this variation, recent developments in cold static preservation and new technological advances with machine perfusion have increased the complexity of the procedure. The objective of the American Association for Thoracic Surgery (AATS) Clinical Practice Standards Committee (CPSC) expert panel was to make evidence-based recommendations for best practices in donor lung procurement and preservation based on review of the existing literature. The AATS CPSC assembled an expert panel of 16 lung transplantation surgeons from 14 centers who developed a consensus document of recommendations. The panel was divided into 7 subgroups covering (1) intraoperative donor assessment, (2) surgical techniques, (3) ex situ static lung preservation methods, (4) hypothermic preservation, (5) normothermic ex vivo lung perfusion (EVLP), (6) donation after circulatory death (DCD) and normothermic regional perfusion, and (7) donor management centers, organ assessment centers, and third-party procurement teams. Following a focused literature review, each subgroup formulated recommendation statements for each subtopic, which were reviewed and further refined using a Delphi process until a 75% consensus was achieved on each final statement by the voting group. The expert panel achieved consensus on 34 recommendations for current best practices in donor lung procurement and preservation both in brain-dead as well as DCD donation. The use of new methods of cold preservation, the role of EVLP, and DCD with and without concomitant heart donation are described in detail. Consistent and best practices in donor lung procurement and preservation are critical to improve both lung transplantation numbers as well as recipient outcomes. The recommendations described here provide guidance for professionals involved in the care of patients with end-stage lung disease considered for transplantation. [ABSTRACT FROM AUTHOR]

Published
2025
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3. Responsabilidad social empresarial, imagen y reputación de la empresa petrolera venezolana.

Author

Briceño Peña, Antonio Nicolás, Flores Gutiérrez, José Ovidio, and Flores Márquez, Sandra Lizbeth

Abstract

Copyright of Contaduría y Administración is the property of Facultad de Contaduria y Administracion-Universidad Nacional Autonoma de Mexico and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2025
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4. Resilience of Fano Resonances in Gold–Silver Nanostructures under Laser-Induced Morphological Transformations

Author

Cuenca, J. Marco, Triviño-Sánchez, Sergio, Barcina, José Osío, Peña-Rodríguez, Ovidio, Guerrero-Martínez, Andrés, González-Rubio, Guillermo, and Pal, Umapada

Abstract

In this study, we explore how the distribution of silver influences the optical and structural properties of pentatwinned gold nanorods, focusing on their transformation under ultrafast laser irradiation. Ag–Au–Ag heterostructures were synthesized, exhibiting a longitudinal plasmon resonance at 800 nm. These structures were irradiated with ultrashort laser pulses, resulting in Ag diffusion from the tips to the sides of the nanorods at low laser fluences. The diffusion process led to the formation of core–shell Au@Ag structures, reducing aspect ratio variability and narrowing the localized surface plasmon resonance (LSPR) band. At higher fluences, the nanorods underwent reshaping into spherical AuAg alloy nanocrystals, causing the disappearance of the longitudinal LSPR and the emergence of a new plasmon band at shorter wavelengths. A Fano resonance (FR), originating from the interference between the localized transverse plasmon mode and the continuum of Au interband transitions, persisted at low fluences but vanished as the structures alloyed. Simulation results confirmed that the FR is sensitive to core–shell configurations and is useful as a marker for detecting structural changes. The findings highlight the potential of laser irradiation for tailoring plasmonic nanomaterials for sensing and photonics.

Published
2025
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6. Gradiente valvular mitral elevado después de la reparación borde a borde: un riesgo desapercibido. Revisión narrativa.

Author

García-Villarreal, Ovidio A.

Abstract

Copyright of Gaceta Médica de México is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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7. Quilomicronemia familiar: nuevas perspectivas

Author

Blanco Echevarría, Agustín, Ariza Corbo, María José, Muñiz-Grijalvo, Ovidio, and Díaz-Díaz, José Luis

Abstract

La quilomicronemia familiar (QF) es un trastorno muy infrecuente, infradiagnosticado y que puede provocar dolor abdominal y pancreatitis recurrente desde la infancia —potencialmente amenazan la vida—, y complicaciones crónicas como diabetes mellitus e insuficiencia pancreática exocrina. La QF afecta a la calidad de vida y salud mental de quienes la padecen, aspectos que hay que tener en cuenta en su tratamiento, basado en una dieta estricta baja en grasas, de difícil adherencia y persistencia. Las personas con QF carecen de capacidad lipolítica para hidrolizar los triglicéridos (TG) y tienen una respuesta mínima o nula a los tratamientos hipolipemiantes convencionales. Los antagonistas de la apoCIII, específicamente volanesorsen, olezarsen y ARO-APOC3, son los fármacos más prometedores para reducir las concentraciones de TG en los pacientes con QF. Las terapias anti-ANGPTL3 parecen ser menos efectivas. Son necesarios más ensayos clínicos y nuevos tratamientos farmacológicos, para mejorar la calidad de vida y el pronóstico de las personas con QF.

Published
2024
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8. Quilomicronemia multifactorial: claves para la detección de las formas severas

Author

Muñiz-Grijalvo, Ovidio, Blanco Echevarría, Agustín, Ariza Corbo, María José, and Díaz-Díaz, José Luis

Abstract

La quilomicronemia multifactorial asociada a múltiples comorbilidades, fármacos y hábitos de vida es con diferencia mucho más frecuente que la quilomicronemia familiar, enfermedad autosómica recesiva que puede considerarse como «enfermedad rara». Al igual que el resto de hipertrigliceridemias, las quilomicronemias podrían clasificarse en primarias o monogénicas y secundarias, en las que, sobre una base de predisposición poligénica, hay una exposición concomitante a múltiples factores desencadenantes. En esta breve revisión repasamos sus causas y manejo, así como las claves para su diagnóstico diferencial.

Published
2024
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9. Bases genéticas de las hipertrigliceridemias

Author

Ariza Corbo, María José, Muñiz-Grijalvo, Ovidio, Blanco Echevarría, Agustín, and Díaz-Díaz, J.L.

Abstract

El desarrollo de las técnicas de secuenciación masiva y las guías para la valoración de la patogenicidad de las variantes está permitiendo la identificación de nuevos casos con quilomicronemia familiar (QF), mayoritariamente en el gen LPL, con menor frecuencia en GPIHBP1y APOA5,y aún con menor número de casos en LMF1y APOC2. De los estudios consultados puede deducirse que, en los casos con síndrome de quilomicronemia multifactorial (SQM), tanto las variantes de pérdida de función como las variantes comunes en los genes canónicos para QF contribuyen a la manifestación de esta otra forma de quilomicronemia. Otras variantes comunes y raras en otros genes del metabolismo de triglicéridos se han identificado en los pacientes con SQM, si bien, no se conocen su impacto real en el desarrollo de la hipertrigliceridemia grave. Puede haber hasta 60 genes implicados en el metabolismo de los triglicéridos, por lo que queda aún un largo camino por recorrer para saber si otros genes no tratados en este monográfico (p. ej., MLXIPL, PLTP, TRIB1, PPARalfa o USF1) son determinantes genéticos de las hipertrigliceridemias graves que son necesarios tener en cuenta.

Published
2024
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10. Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study

Author

Elshorbagy, Amany, Lyons, Alexander R.M., Vallejo-Vaz, Antonio J., Stevens, Christophe A.T., Dharmayat, Kanika I., Brandts, Julia, Catapano, Alberico L., Freiberger, Tomas, Hovingh, G. Kees, Mata, Pedro, Raal, Frederick J., Santos, Raul D., Soran, Handrean, Watts, Gerald F., Abifadel, Marianne, Aguilar-Salinas, Carlos A., Alhabib, Khalid F., Alkhnifsawi, Mutaz, Almahmeed, Wael, Alonso, Rodrigo, Al-Rasadi, Khalid, Al-Sarraf, Ahmad, Ashavaid, Tester F., Banach, Maciej, Binder, Christoph J., Bourbon, Mafalda, Brunham, Liam R., Chlebus, Krzysztof, Corral, Pablo, Cruz, Diogo, Davletov, Kairat, Descamps, Olivier S., Ezhov, Marat, Gaita, Dan, Groselj, Urh, Harada-Shiba, Mariko, Holven, Kirsten B., Kayikcioglu, Meral, Khovidhunkit, Weerapan, Lalic, Katarina, Latkovskis, Gustavs, Laufs, Ulrich, Liberopoulos, Evangelos, Lima-Martinez, Marcos M., Lin, Jie, Maher, Vincent, Marais, A. David, März, Winfried, Mirrakhimov, Erkin, Miserez, André R., Mitchenko, Olena, Nawawi, Hapizah, Nordestgaard, Børge G., Panayiotou, Andrie G., Paragh, György, Petrulioniene, Zaneta, Pojskic, Belma, Postadzhiyan, Arman, Reda, Ashraf, Reiner, Željko, Reyes, Ximena, Sadiq, Fouzia, Sadoh, Wilson E., Schunkert, Heribert, Shek, Aleksandr B., Stroes, Erik, Su, Ta-Chen, Subramaniam, Tavintharan, Susekov, Andrey V., Tilney, Myra, Tomlinson, Brian, Truong, Thanh-Huong, Tselepis, Alexandros D., Tybjærg-Hansen, Anne, Vázquez, Alejandra C., Viigimaa, Margus, Vohnout, Branislav, Wang, Luya, Yamashita, Shizuya, Arca, Marcello, Averna, Maurizio, Schreier, Laura, Pang, Jing, Ebenbichler, Christoph, Dieplinger, Hans, Innerhofer, Reinhold, Winhofer-Stöckl, Yvonne, Greber-Platzer, Susanne, Krychtiuk, Konstantin, Speidl, Walter, Toplak, Hermann, Widhalm, Kurt, Stulnig, Thomas, Huber, Kurt, Höllerl, Florian, Rega-Kaun, Gersina, Kleemann, Lucas, Mäser, Martin, Scholl-Bürgi, Sabine, Säly, Christoph, Mayer, Florian J., Sperone, Alexandra, Tanghe, Chloé, Gérard, Anne-Catherine, Pojskic, Lamija, Sisic, Ibrahim, Durak Nalbantic, Azra, Ejubovic, Malik, Jannes, Cinthia E., Pereira, Alexandre C., Krieger, Jose E., Petrov, Ivo, Goudev, Assen, Nikolov, Fedya, Tisheva, Snejana, Yotov, Yoto, Tzvetkov, Ivajlo, Baass, Alexis, Bergeron, Jean, Bernard, Sophie, Brisson, Diane, Brunham, Liam R., Cermakova, Lubomira, Couture, Patrick, Francis, Gordon A., Gaudet, Daniel, Hegele, Robert A., Khoury, Etienne, Mancini, G.B. John, McCrindle, Brian W., Paquette, Martine, Ruel, Isabelle, Iatan, Iulia, Cuevas, Ada, Wang, Xumin, Meng, Kang, Song, Xiantao, Yong, Qiang, Jiang, Tao, Liu, Ziyou, Duan, Yanyu, Hong, Jing, Ye, Pucong, Chen, Yan, Qi, Jianguang, Liu, Zesen, Li, Yuntao, Zhang, Chaoyi, Peng, Jie, Yang, Ya, Yu, Wei, Wang, Qian, Yuan, Hui, Cheng, Shitong, Jiang, Long, Chong, Mei, Jiao, Jian, Wu, Yue, Wen, Wenhui, Xu, Liyuan, Zhang, Ruiying, Qu, Yichen, He, Jianxun, Fan, Xuesong, Wang, Zhenjia, Chow, Elaine, Pećin, Ivan, Perica, Dražen, Symeonides, Phivos, Vrablik, Michal, Ceska, Richard, Soska, Vladimir, Tichy, Lukas, Adamkova, Vera, Franekova, Jana, Cifkova, Renata, Kraml, Pavel, Vonaskova, Katerina, Cepova, Jana, Dusejovska, Magdalena, Pavlickova, Lenka, Blaha, Vladimir, Rosolova, Hana, Nussbaumerova, Barbora, Cibulka, Roman, Vaverkova, Helena, Cibickova, Lubica, Krejsova, Zdenka, Rehouskova, Katerina, Malina, Pavel, Budikova, Milena, Palanova, Vaclava, Solcova, Lucie, Lubasova, Alena, Podzimkova, Helena, Bujdak, Juraj, Vesely, Jiri, Jordanova, Marta, Salek, Tomas, Urbanek, Robin, Zemek, Stanislav, Lacko, Jan, Halamkova, Hana, Machacova, Sona, Mala, Sarka, Cubova, Eva, Valoskova, Katerina, Burda, Lukas, Benn, Marianne, Bendary, Ahmed, Daoud, Ihab, Emil, Sameh, Elbahry, Atef, Rafla, Samir, Sanad, Osama, Kazamel, Ghada, Ashraf, Dr Mohamed, Sobhy, Mohamed, El-Hadidy, Amro, Shafy, Mohamed Abdoul, Kamal, Saif, Bendary, Mohamed, Talviste, Grete, Christmann, Jutta, Dressel, Alexander, Fath, Felix, Ferraro, Chiara, Frenzke, Lydia, Gopon, Alica, Klein, Isabel, Pienkowska, Dominika, Sietmann, Tobias, Sonntag, Antonia, Adjan, Omar, Bahrmann, Philipp, Baessler, Andrea, Barkowski, Rasmus, Beckerdjian, Raffi, Berr, Christina, Birkenfeld, Andreas, Böll, Gereon, Carstensen, Avisha, Demuth, Ilya, Finkernagel, Holger, Gouni-Berthold, Ioanna, Hahmann, Harry, Hamerle, Michael, Halder, Julian, Heide, Maria, Julius, Ulrich, Kassner, Ursula, Katzmann, Julius L, Kirschbaum, Anja, Klose, Gerald, Könemann, Stephanie, König, Christel, König, Wolfgang, Krämer, Bernhard, Kuprat, Gerrit, Koschker, Ann-Cathrin, Krämer, Bernhard, Kilic, Özlem, Laufs, Ulrich, Lindenmeier, Gerd, Van de Loo, Iris, Lorenz, Babette, Lorenz, Elke, Löhr, Birgit, McChord, Johanna, Maslarska, Mariya, Methe, Heiko, Merkel, Martin, Moussaoui, Zineb, Müller-Kozarez, Irina, Olivier, Christoph B, Ong, Peter, Otte, Britta, Parhofer, Klaus, Partsch, Carl-Joachim, Paulus, Michael, Pehlivanli, Sinan, Pflederer, Tobias, Pusl, Thomas, Richter, Veronika, Rosner, Stefanie, Sanin, Veronika, Schäfer, Sebastian, Schäfer, Christoph, Schatz, Ulrike, Schirmer, Stephan, Schmidt, Christine, Seeger, Wolfgang, Sisovic, Snezna, Spens, Antje, Jablonski, Ksenija Stach, Stadelmann, Alexander, Steinhagen-Thiessen, Elisabeth, Stürzebecher, Paulina, Tafelmeier, Maria, Tillack, Dörthe, Tselmin, Sergey, Tünnemann-Tarr, Adrienn, Vogt, Anja, Beckerath, Jens von, Wilke, Andreas, Wolf, Ulrich, Zemmrich, Claudia, Rizos, Christos V., Skoumas, Ioannis, Tziomalos, Konstantinos, Rallidis, Loukianos, Kotsis, Vasileios, Doumas, Michalis, Athyros, Vasileios, Skalidis, Emmanouil, Kolovou, Genovefa, Kolovou, Vana, Garoufi, Anastasia, Bilianou, Eleni, Koutagiar, Iosif, Kiouri, Estela, Antza, Christina, Zacharis, Evangelos, Attilakos, Achilleas, Sfikas, George, Koumaras, Charalambos, Anagnostis, Panagiotis, Anastasiou, Georgia, Liamis, George, Koutsogianni, Amalia-Despoina, Petkou, Ermioni, Milionis, Haralambos, Koulouri, Anastasia, Prodromiadou, Elisavet, Karányi, Zsolt, Harangi, Mariann, Bajnok, László, Audikovszky, Mária, Márk, László, Benczúr, Béla, Reiber, István, Nagy, Gergely, Nagy, András, Reddy, Lakshmi Lavanya, Shah, Swarup A. V, Ponde, Chandrashekhar K., Dalal, Jamshed J., Sawhney, Jitendra P.S., Verma, Ishwar C., Altaey, Mays, Al-Jumaily, Khalid, Rasul, Dilshad, Abdalsahib, Ali Fawzi, Jabbar, Amer Abdl, Al-ageedi, Mohanad, Abdalsahib, Ali Fawzi, Al-ageedi, Mohanad, Dhamin, Mohammed, AlFil, Sarmad, Khadhim, Foad, Miahy, Sabah, Agar, Ruth, Catapano, Alberico Luigi, Arca, Marcello, Averna, Maurizio, Calandra, Sebastiano, Tarugi, Patrizia, Casula, Manuela, Galimberti, Federica, Olmastroni, Elena, Sarzani, Riccardo, Ferri, Claudio, Repetti, Elena, Piro, Salvatore, Suppressa, Patrizia, Meregalli, Giancarla, Borghi, Claudio, Muntoni, Sandro, Calabrò, Paolo, Cipollone, Francesco, Purrello, Francesco, Pujia, Arturo, Passaro, Angelina, Marcucci, Rossella, Pecchioli, Valerio, Pisciotta, Livia, Mandraffino, Giuseppe, Pellegatta, Fabio, Mombelli, Giuliana, Branchi, Adriana, Fiorenza, Anna Maria, Pederiva, Cristina, Werba, Josè Pablo, Parati, Gianfranco, Carubbi, Francesca, Iughetti, Lorenzo, Fortunato, Giuliana, Iannuzzi, Arcangelo, Iannuzzo, Gabriella, Cefalù, Angelo Baldassare, Biasucci, Giacomo, Zambon, Sabina, Pirro, Matteo, Sbrana, Francesco, Trenti, Chiara, D'Erasmo, Laura, Federici, Massimo, Ben, Maria Del, Bartuli, Andrea, Giaccari, Andrea, Pipolo, Antonio, Citroni, Nadia, Guardamagna, Ornella, Lia, Salvatore, Benso, Andrea, Biolo, Gianni, Maroni, Lorenzo, Lupi, Alessandro, Bonanni, Luca, Rinaldi, Elisabetta, Zenti, Maria Grazia, Matsuki, Kota, Hori, Mika, Ogura, Masatsune, Masuda, Daisaku, Kobayashi, Takuya, Nagahama, Kumiko, Al-Jarallah, Mohammed, Radovic, Mirjana, Lunegova, Olga, Bektasheva, Erkayim, Abilova, Saamay, Erglis, Andrejs, Gilis, Dainus, Nesterovics, Georgijs, Saripo, Vita, Meiere, Ruta, Skudrina, Gunda, Terauda, Elizabete, Jambart, Selim, Ayoub, Carine, Ghaleb, Youmna, Aliosaitiene, Urte, Kutkiene, Sandra, Abdul Kadir, Siti Hamimah Sheikh, Kasim, Noor Alicezah Mohd, Nor, Noor Shafina Mohd, Abdul Hamid, Hasidah, Abdul Razak, Suraya, Al-Khateeb, Alyaa, Abd Muid, Suhaila, Abdul Rahman, Thuhairah, Kasim, Sazzli Shahlan, Radzi, Ahmad Bakhtiar Md, Ibrahim, Khairul Shafiq, Rosli, Marshima Mohd, Razali, Rafezah, Chua, Yung An, Razman, Aimi Zafira, Nazli, Sukma Azureen, Aziz, Nazirul, Rosman, Azhari, Abdul Murad, NorAzian, Jalaludin, Mohd Amin, Abdul Latif, Ahmad Zubaidi, Azzopardi, C., Mehta, Roopa, Martagon, Alexandro J., Ramirez, Gabriela A. Galan, Villa, Neftali E Antonio, Vazquez, Arsenio Vargas, Elias-Lopez, Daniel, Retana, Gustavo Gonzalez, Rodriguez, Betsabel, Macías, Jose J. Ceballos, Zazueta, Alejandro Romero, Alvarado, Rocio Martinez, Portano, Julieta D. Morales, Lopez, Humberto Alvares, Sauque-Reyna, Leobardo, Herrera, Laura G. Gomez, Mendia, Luis E. Simental, Aguilar, Humberto Garcia, Cooremans, Elizabeth Ramirez, Aparicio, Berenice Peña, Zubieta, Victoria Mendoza, Gonzalez, Perla A. Carrillo, Ferreira-Hermosillo, Aldo, Portilla, Nacu Caracas, Dominguez, Guadalupe Jimenez, Garcia, Alinna Y. Ruiz, Cazares, Hector E. Arriaga, Gonzalez, Jesus R., Valencia, Carla V. Mendez, Padilla, Francisco G., Prado, Ramon Madriz, Ibarra, Manuel O. De los Rios, Villicaña, Ruy D. Arjona, Rivera, Karina J. Acevedo, Carrera, Ricardo Allende, Alvarez, Jose A., Martinez, Jose C. Amezcua, Bustillo, Manuel de los Reyes Barrera, Vargas, Gonzalo Carazo, Chacon, Roberto Contreras, Andrade, Mario H. Figueroa, Ortega, Ashanty Flores, Alcala, Hector Garcia, de Leon, Laura E. Garcia, Guzman, Berenice Garcia, Garcia, Jose J. Garduño, Cuellar, Juan C. Garnica, Cruz, Jose R. Gomez, Garcia, Anell Hernandez, Almada, Jesus R. Holguin, Herrera, Ursulo Juarez, Sobrevilla, Fabiola Lugo, Rodriguez, Eduardo Marquez, Sibaja, Cristina Martinez, Rodriguez, Alma B. Medrano, Oyervides, Jose C. Morales, Vazquez, Daniel I. Perez, Rodriguez, Eduardo A. Reyes, Osorio, Ma. Ludivina Robles, Saucedo, Juan Rosas, Tamayo, Margarita Torres, Talavera, Luis A. Valdez, Arroyo, Luis E. Vera, Carrillo, Eloy A. Zepeda, Stroes, Erik S, Defesche, J, Zuurbier, L, Reeskamp, L, Ibrahim, S, Roeters van Lennep, Jeanine, Wiegman, Albert, Isara, Alphonsus, Obaseki, Darlington E., Al-Waili, Khalid, Al-Zadjali, Fahad, Al-Zakwani, Ibrahim, Al-Kindi, Mohammed, Al-Mukhaini, Suad, Al-Barwani, Hamida, Rana, Asim, Shah, Lahore Saeed Ullah, Al-Nouri, Fahad, Starostecka, Ewa, Konopka, Agnieszka, Bielecka-Dabrowa, Agata, Lewek, Joanna, Sosnowska, Bozena, Gąsior, Mariusz, Dyrbuś, Krzysztof, Jóźwiak, Jacek, Pajkowski, Marcin, Romanowska-Kocejko, Marzena, Żarczyńska-Buchowiecka, Marta, Chmara, Magdalena, Wasąg, Bartosz, Stróżyk, Aneta, Michalska-Grzonkowska, Aleksandra, Medeiros, Ana Margarida, Alves, Ana Catarina, Silva, Francisco, Lobarinhas, Goreti, Palma, Isabel, de Moura, Jose Pereira, Rico, Miguel Toscano, Rato, Quitéria, Pais, Patrícia, Correia, Susana, Moldovan, Oana, Virtuoso, Maria João, Araujo, Francisco, Salgado, Jose Miguel, Colaço, Ines, Dumitrescu, Andreea, Lengher, Calin, Mosteoru, Svetlana, Meshkov, Alexey, Ershova, Alexandra, Rozhkova, Tatiana, Korneva, Victoria, Yu, Kuznetsova T., Zafiraki, Vitaliy, Voevoda, Mikhail, Gurevich, Victor, Duplyakov, Dmitry, Ragino, Yulia, Chubykina, Uliana, Shaposhnik, Igor, Alkaf, Fahmi, Khudari, Alia, Rwaili, Nawal, Al-Allaf, Faisal, Alghamdi, Mohammad, Batais, Mohammed A, Almigbal, Turky H, Kinsara, Abdulhalim, AlQudaimi, Ashraf Hammouda Ahmed, Awan, Zuhier, Elamin, Omer A, Altaradi, Hani, Popovic, Ljiljana, Singh, Sandra, Rasulic, Iva, Petakov, Ana, Lalic, Nebojsa M., Lam, Carolyn, Le, Tan Ju, Siang, Eric Lim Tien, Dissanayake, Sanjaya, I-Shing, Justin Tang, Shyong, Tai E, Jin, Terrance Chua Siang, Ting, Sharon Pek Li, Ming, Jeremy Hoe Kian, Drum, Chester Lee, Nastar, Fathima Ashna, Jia, Loh Wann, Ya, Natalie Koh Si, Jie, Marvin Chua Wei, Dalan, Rinkoo, Wei, Yong Quek, sian, Tiong Yee, Keong, Yeo Khung, Rong, Siau Kai, Jin, Darren Seah Ee, Ming, Ian Koh Jan, Chang, Tan Hong, Peng, Fabian Yap Kok, Vasanwala, Rashida Farhad, Raslova, Katarina, Balinth, Karin, Buganova, Ingrid, Fabryova, Lubomira, Kadurova, Michaela, Klabnik, Alexander, Kozárová, Miriam, Sirotiakova, Jana, Battelino, Tadej, Cevc, Matija, Debeljak, Marusa, Torkar, Ana Drole, Fras, Zlatko, Jug, Borut, Cugalj, Barbara Kern, Kovac, Jernej, Mlinaric, Matej, Sikonja, Jaka, Pilcher, Gillian Joan, Blom, D J, Wolmarans, K H, Brice, B C, Muñiz-Grijalvo, Ovidio, Díaz-Díaz, Jose Luis, de Isla, Leopoldo Pérez, Fuentes, Francisco, Badimon, Lina, Martin, François, Miserez, Eleonore B., Shipton, Janine L., Ganokroj, Poranee, Chattranukulchai, Pairoj, Jiamjarasrungsi, Wiroj, Thongtang, Nuntakorn, Krittayaphong, Rungroj, Vathesatogkit, Prin, Sriphrapradang, Chutintorn, Phimphilai, Mattabhorn, Leelawattana, Rattana, Anthanont, Pimjai, Suraamornkul, Swangjit, Deerochanawong, Chaicharn, Senthong, Vichai, Torpongpun, Artit, Suteerayongprasert, Panuwat, Pengpong, Nawarat, Sathavarodom, Nattapol, Sunanta, Usanee, Porntharukchareon, Thachanun, Kiatpanabhikul, Phatharaporn, Kaewkrasaesin, Chatchon, Kongkit, Jaruwan, Umphonsathien, Mongkontida, Akbulut, Mehmet, Alici, Gökhan, Bayram, Fahri, Can, Levent Hürkan, Celik, Ahmet, Ceyhan, Ceyhun, Coskun, Fatma Yilmaz, Demir, Mesut, Demircan, Sabri, Dogan, Volkan, Durakoglugil, Emre, Dural, İbrahim Etem, Gedikli, Omer, Hacioglu, Aysa, Ildizli, Muge, Kilic, Salih, Kirilmaz, Bahadir, Kutlu, Merih, Oguz, Aytekin, Ozdogan, Oner, Onrat, Ersel, Ozer, Savas, Sabuncu, Tevfik, Sahin, Tayfun, Sivri, Fatih, Sonmez, Alper, Temizhan, Ahmet, Topcu, Selim, Tokgozoglu, Lale, Tuncez, Abdullah, Vural, Mirac, Yenercag, Mustafa, Yesilbursa, Dilek, Yigit, Zerrin, Yildirim, Aytul Belgi, Yildirir, Aylin, Yilmaz, Mehmet Birhan, Atallah, Bassam, Traina, Mahmoud, Sabbour, Hani, Abdul Hay, Dana, Luqman, Neama, Elfatih, Abubaker, Abdulrasheed, Arshad, Manla, Yosef, Kwok, See, DellOca, Nicolas, Alieva, Rano B., Fozilov, Khurshid G., Hoshimov, Shavkat U., Nizamov, Ulugbek I., Kan, Liliya E., Kim, Andrey R., Abdullaeva, Guzal J., Abdullaev, Alisher A., Do, Doan Loi, Nguyen, Mai Ngoc Thi, Kim, Ngoc Thanh, Le, Thanh Tung, Le, Hong An, and Ray, Kausik K.

Abstract

Statins are the cornerstone treatment for patients with heterozygous familial hypercholesterolaemia but research suggests it could increase the risk of type 2 diabetes in the general population. A low prevalence of type 2 diabetes was reported in some familial hypercholesterolaemia cohorts, raising the question of whether these patients are protected against type 2 diabetes. Obesity is a well known risk factor for the development of type 2 diabetes. We aimed to investigate the associations of known key determinants of type 2 diabetes with its prevalence in people with heterozygous familial hypercholesterolaemia.

Published
2024
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11. High-Temperature Superconducting Magnetic Levitation With the Halbach Array and V-Shaped Combined Permanent Magnet Guideway

Author

Gao, Lingfeng, Deng, Zigang, Hu, Xianhong, Zhou, Xucheng, Zhang, Weihua, and D'Ovidio, Gino

Abstract

The permanent magnet guideways (PMGs), serving as the sole magnetic field source for the high-temperature superconducting (HTS) pinning maglev system, exert a profound influence on the levitation performance of HTS bulks through its magnetic field distribution. To improve the levitation performance of HTS maglev systems, experiments to measure levitation and guidance forces were conducted using the 165-m test line PMG completed by Southwest Jiaotong University in 2021. Additionally, finite-element simulation models were developed. Subsequently, utilizing this simulation model as a foundation, a V-shaped Halbach array PMG was designed by combining a Halbach array with a “V” structure. Subsequently, the V-shaped PMG underwent simulation optimization with the goal of maximizing the levitation force. The optimized V-shaped PMG, when compared with the test line PMG with the same cross-sectional area, exhibits significant improvements. Under the zero-field cooling (FC) condition with a 15 mm lateral displacement, the levitation force experienced a 39.1% increase at the working height, while the guidance force showed a substantial 274.9% improvement. Similarly, under the FC condition with a 15-mm lateral displacement, there was a 43.6% increase in levitation force and a 186.1% increase in guidance force. These data unequivocally demonstrate the considerable application potential of the V-shaped PMG when compared with the test line PMG.

Published
2024
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12. Fractional boundary value problems and elastic sticky brownian motions

Author

D’Ovidio, Mirko

Abstract

We extend the results obtained in [14] by introducing a new class of boundary value problems involving non-local dynamic boundary conditions. We focus on the problem to find a solution to a local problem on a domain Ωwith non-local dynamic conditions on the boundary ∂Ω. Due to the pioneering nature of the present research, we propose here the apparently simple case of Ω=(0,∞)with boundary {0}of zero Lebesgue measure. Our results turn out to be instructive for the general case of boundary with positive (finite) Borel measures. Moreover, in our view, we bring new light to dynamic boundary value problems and the probabilistic description of the associated models.

Published
2024
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13. Reirradiation of gliomas with hypofractionated stereotactic radiotherapy: efficacy and tolerance analysis at a single center.

Author

González, Mercedes López, Ciervide, Raquel, Requejo, Ovidio Hernando, Luis, Ángel Montero, Rodriguez, Beatriz Álvarez, Saugar, Emilio Sánchez, Iracheta, Leyre Alonso, Xin Chen, Garcia-Aranda, Mariola, Zucca, Daniel, Valero, Jeannette, Alonso, Rosa, Fernández-Letón, Pedro, and Rubio, Carmen

Abstract

Background: Recurrent high-grade gliomas present a therapeutic challenge. Repeat surgery, re-irradiation, and systemic therapy have been explored, with re-irradiation requiring precise tumor relapse delineation and advanced dosimetric techniques. This study aims to evaluate the effectiveness and tolerability of re-irradiation using Hypofractionated Stereotactic Radiation (HFSRT) schedules. Materials and methods: In a retrospective analysis from 2011 to 2021, 52 adult patients with recurrent high-grade gliomas were examined, including 42.3% with glioblastoma, 32.5% with grade 3 gliomas, and 25% with grade 2 gliomas as initial diagnosis. All received prior radiotherapy at doses ranging from 54-60 Gy, with a median time to tumor relapse of 19.8 months. Salvage surgery was performed in 42.3% of cases, with a median interval of 22.45 months between radiation courses. Re-irradiation doses were 30 Gy in 5 fractions for 54% and 40 Gy in 10 fractions for 46%. Concurrent systemic treatments included temozolomide (30.8%), nevacizumab (27%), or none (35%). Results: In-field and out-field tumor progression occurred in 65.4% and 25% of patients, with median times to local and distant progression of 5.17 and 4.57 months. Median overall survival (OS) from re-irradiation was 12 months. Univariate analysis showed a trend favoring 30 Gy in 5 fractions for disease progression-free survival (DPFS). Treatment was generally well-tolerated, with only 5.7% experiencing acute Grade-3 toxicity, and symptomatic radionecrosis occurred in 2 patients. Conclusion: Re-irradiation using HFSRT for recurrent high-grade gliomas is viable and well-tolerated, demonstrating survival rates comparable to existing literature. These findings underscore the potential of HFSRT in managing recurrent high-grade gliomas. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Safety and efficacy of a class II medical device based on highly purified and standardized plant extracts in the management of post-menopausal patients with vulvar and vaginal atrophy: a single-center prospective observational study.

Author

GALLI, Valerio, GOLIA D'AUGÈ, Tullio, DI PIERRO, Francesco, CAZZANIGA, Massimiliano, GUASTI, Luigina, ZERBINATI, Nicola, BERTUCCIOLI, Alexander, KHAN, Amjad, D'OVIDIO, Giulia, IACULLI, Francesco, TIBALDI, Valentina, SANTANGELO, Giusi, FISCHETTI, Margherita, CASORELLI, Assunta F., DI DONATO, Violante, GIANNINI, Andrea, MUSELLA, Angela, GIANCOTTI, Antonella, and MONTI, Marco

Subjects
MEDICAL personnel, SENTINEL lymph node biopsy, BODY mass index, CARBON dioxide lasers, HORMONE therapy, PREMATURE menopause, VULVAR cancer
Published
2024
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15. Emerging materials and technologies for advancing bioresorbable surgical meshes.

Author

Shiroud Heidari, Behzad, Dodda, Jagan Mohan, El-Khordagui, Labiba K., Focarete, Maria Letizia, Maroti, Peter, Toth, Luca, Pacilio, Serafina, El-Habashy, Salma E., Boateng, Joshua, Catanzano, Ovidio, Sahai, Nitin, Mou, Lingjun, and Zheng, Minghao

Subjects
GUIDED bone regeneration, SURGICAL complications, BONE regeneration, BIOPOLYMERS, PELVIC floor, SURGICAL meshes
Abstract

Surgical meshes play a significant role in the treatment of various medical conditions, such as hernias, pelvic floor issues, guided bone regeneration, and wound healing. To date, commercial surgical meshes are typically made of non-absorbable synthetic polymers, notably polypropylene and polytetrafluoroethylene, which are associated with postoperative complications, such as infections. Biological meshes, based on native tissues, have been employed to overcome such complications, though mechanical strength has been a main disadvantage. The right balance in mechanical and biological performances has been achieved by the advent of bioresorbable meshes. Despite improvements, recurrence of clinical complications associated with surgical meshes raises significant concerns regarding the technical adequacy of current materials and designs, pointing to a crucial need for further development. To this end, current research focuses on the design of meshes capable of biomimicking native tissue and facilitating the healing process without post-operative complications. Researchers are actively investigating advanced bioresorbable materials, both synthetic polymers and natural biopolymers, while also exploring the performance of therapeutic agents, surface modification methods and advanced manufacturing technologies such as 4D printing. This review seeks to evaluate emerging biomaterials and technologies for enhancing the performance and clinical applicability of the next-generation surgical meshes. In the ever-transforming landscape of regenerative medicine, the embracing of engineered bioabsorbable surgical meshes stands as a key milestone in addressing persistent challenges and complications associated with existing treatments. The urgency to move beyond conventional non-absorbable meshes, fraught with post-surgery complications, emphasises the necessity of using advanced biomaterials for engineered tissue regeneration. This review critically examines the growing field of absorbable surgical meshes, considering their potential to transform clinical practice. By strategically combining mechanical strength with bioresorbable characteristics, these innovative meshes hold the promise of mitigating complications and improving patient outcomes across diverse medical applications. As we navigate the complexities of modern medicine, this exploration of engineered absorbable meshes emerges as a promising approach, offering an overall perspective on biomaterials, technologies, and strategies adopted to redefine the future of surgical meshes. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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16. La enfermedad de mano, pie y boca en niños: una revisión sistemática.

Author

Herrera Ortiz, José Uberli, Oblitas Gonzáles, Aníbal, and Carranza, Wilder Ovidio Carranza

Abstract

Copyright of Revista Horizonte Médico is the property of Universidad de San Martin de Porres and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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17. Long-term sex differences in atherosclerotic cardiovascular disease in individuals with heterozygous familial hypercholesterolaemia in Spain: a study using data from SAFEHEART, a nationwide, multicentre, prospective cohort study

Author

de Isla, Leopoldo Pérez, Vallejo-Vaz, Antonio J, Watts, Gerald F, Muñiz-Grijalvo, Ovidio, Alonso, Rodrigo, Diaz-Diaz, Jose L, Arroyo-Olivares, Raquel, Aguado, Rocio, Argueso, Rosa, Mauri, Marta, Romero, Manuel J, Álvarez-Baños, Pilar, Mañas, Dolores, Cepeda, José María, Gonzalez-Bustos, Pablo, Casañas, Marta, Michan, Alfredo, Muñoz-Torrero, Juan F Sánchez, Faedo, Ceferino, Barba, Miguel A, Dieguez, Marta, de Andrés, Raimundo, Hernandez, Antonio M, Gonzalez-Estrada, Aurora, Padró, Teresa, Fuentes, Francisco, Badimon, Lina, and Mata, Pedro

Abstract

Sex differences in atherosclerotic cardiovascular disease (ASCVD) in familial hypercholesterolaemia have been reported but are not fully established. We aimed to assess sex differences in the risk of ASCVD and life-time burden of ASCVD in patients with heterozygous familial hypercholesterolaemia.

Published
2024
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19. Current landscape of gastrointestinal radiation oncology in Spain: a multicenter real-life survey and comparison with key clinical guidelines.

Author

Hernando-Requejo, Ovidio, Torres Olombrada, Maria Victoria, Bravo, Irene Alda, Moreno, Leire Arbea, López-Campos, Fernando, López Gonzalez, Mercedes, Martín, Margarita Martín, Morillo Macías, Virginia, and De la Pinta, Carolina

Abstract

Background: The GI Tumors Workgroup, a division of the Spanish Society of Radiation Therapy, conducted a survey in December 2020 to assess the adherence of radiation oncologists in Spain to international guidelines for gastrointestinal tumors. Materials and methods: Using Google Forms, we designed a survey covering treatments for esophageal, gastric, pancreatic, and rectal cancers. Results: In esophageal cancer treatment, neoadjuvant chemoradiation was the standard in 76.7% of institutions. Radiation doses range from 41.1 to 50.4 Gy in conventional fractionation. Planning positron emission tomography-computed tomography (PET-CT) was performed in 83.3% of centers, and intensity-modulated radiation therapy/volumetric-arc radiation therapy (IMRT/VMAT) was the preferred technique in 86.7% of institutions. For gastric cancer, 71.4% followed perioperative chemotherapy guidelines. In the case of adjuvant radiotherapy, the majority prescribed 45-50.4 Gy, and 82.1% used IMRT/VMAT for treatment. For pancreas cancer, neoadjuvant chemotherapy followed by surgery in borderline resectable tumors and induction chemotherapy followed by radical radiotherapy for non-resectable tumors were the most frequent approaches. IMRT/VMAT was the primary technique. Locally advanced rectal cancer treatment is mainly based on neoadjuvant radiotherapy in all institutions. The preferred radiation doses typically range from 45 to 50 Gy in conventional fractionation. IMRT/VMAT was standard in most Institutions. Conclusions: Spain's radiotherapy practices among respondents generally align with international guidelines for GI tumors highlighting Spain's commitment to evidence-based medical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Prácticas parentales asociadas a la crianza reflexiva.

Author

Herrera Rivera, Ovidio, Bedoya Cardona, Ledy Maryory, and Gómez Zuluaga, Diana Marcela

Subjects
CONSCIOUSNESS raising, METROPOLITAN areas, WELL-being, MOTHERS, FATHERS
Abstract

Copyright of Revista Virtual Universidad Católica del Norte is the property of Revista Virtual Universidad Catolica del Norte and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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21. PIETRO PASTORELLI E LA STORIA DELLA POLITICA ESTERA ITALIANA.

Author

D'OVIDIO, FRANCESCO LEFEBVRE

Abstract

Copyright of Nuova Rivista Storica is the property of Societa Editrice Dante Alighieri s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

24. EVALUACIÓN DE HUELLA DE CARBONO EN EL TRATAMIENTO DE AGUAS RESIDUALES URBANAS EN LAS ISLAS CANARIAS.

Author

Lorenzo-Quijada, Raúl-Althay, Pérez-Báez, Sebastián-Ovidio, Martín, Alejandro-Ramos, de-Rio-Gamero, Beatriz, Vaswani-Reboso, Jenifer, and Hernández-Zerpa, Harue

Subjects
SEWAGE disposal plants, ECOLOGICAL impact, WATER pollution, SEWAGE, POLLUTION
Abstract

Copyright of DYNA: Energía y Sostenibilidad is the property of Publicaciones Dyna SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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25. Coronary Plaque Characteristics Associated With Major Adverse Cardiovascular Events in Atherosclerotic Patients and Lesions: A Systematic Review and Meta-Analysis.

Author

Gallone, Guglielmo, Bellettini, Matteo, Gatti, Marco, Tore, Davide, Bruno, Francesco, Scudeler, Luca, Cusenza, Vincenzo, Lanfranchi, Antonio, Angelini, Andrea, de Filippo, Ovidio, Iannaccone, Mario, Baldetti, Luca, Audisio, Katia, Demetres, Michelle, Risi, Gaetano, Rizzello, Giulia, Porto, Italo, Fonio, Paolo, Prati, Francesco, and Williams, Michelle C.

Abstract

The clinical value of high-risk coronary plaque characteristics (CPCs) to inform intensified medical therapy or revascularization of non–flow-limiting lesions remains uncertain. The authors performed a systematic review and meta-analysis to study the prognostic impact of CPCs on patient-level and lesion-level major cardiovascular adverse events (MACE). Thirty studies (21 retrospective, 9 prospective) with 30,369 patients evaluating the association of CPCs with MACE were included. CPCs included high plaque burden, low minimal lumen area, thin cap fibroatheroma, high lipid core burden index, low-attenuation plaque, spotty calcification, napkin ring sign, and positive remodeling. CPCs were evaluated with the use of intracoronary modalities in 9 studies (optical coherence tomography in 4 studies, intravascular ultrasound imaging in 3 studies, and near-infrared spectroscopy intravascular ultrasound imaging in 2 studies) and by means of coronary computed tomographic angiography in 21 studies. CPCs significantly predicted patient-level and lesion-level MACE in both unadjusted and adjusted analyses. For most CPCs, accuracy for MACE was modest to good at the patient level and moderate to good at the lesion level. Plaques with more than 1 CPC had the highest accuracy for lesion-level MACE (AUC: 0.87). Because the prevalence of CPCs among plaques was low, estimated positive predictive values for lesion-level MACE were modest. Results were mostly consistent across imaging modalities and clinical presentations, and in studies with prevailing hard outcomes. Characterization of CPCs identifies high-risk atherosclerotic plaques that place lesions and patients at risk for future MACE, albeit with modest sensitivity and positive predictive value (Coronary Plaque Characteristics Associated With Major Adverse Cardiovascular Events Among Atherosclerotic Patients and Lesions; CRD42021251810) [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2023
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28. Sustainable eating in the "new normal" Italy: ecological food habitus between biospheric values and de-globalizing gastronationalism.

Author

Onorati, Maria Giovanna and d'Ovidio, Francesco Domenico

Subjects
VALUES (Ethics), COVID-19 pandemic, FOOD habits, NUTRITION surveys, FOOD preferences, INGESTION, PREPAREDNESS
Abstract

This article presents the results of a survey on sustainable food consumption in Italy during COVID-19 times. The study examines the changes triggered by the pandemic, both in sustainable food practises and in consumers' value-based priorities. The goal is to identify the structuring of an ecological dietary habitus and even a culinary ethos as attention is paid to the reflexive, axiological dimensions of emerging eating habits. The complexity of the phenomenon has suggested a multi-paradigmatic research approach that accounts for the role of human agency in restructuring eating practises in transitional times. The results highlight an emerging nonlinear axiology in which biospheric universalism ambiguously coexists with the lionizing of locavorism and the glorification of food origins, and the direct provision of local food gains prominence despite the increasing mediatization of food choices. A deglobalizing eating style is emerging, where ecological instantiations seem to indulge culinary nationalism and conservative communitarianism. One of the challenges of the "new normal" will be to endow these dispositions with the axiological coherence of an appropriate ecological culinary ethos, as well as to create the conditions for younger generations to prioritize forward-looking ecological values over conservative gastronationalism to promote the sustainable regeneration of food systems. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Preparation of human primary macrophages to study the polarization from monocyte-derived macrophages to pro- or anti-inflammatory macrophages at biomaterial interface in vitro.

Author

Parisi, Ludovica, Bianchi, Massimiliano Giovanni, Ghezzi, Benedetta, Maurizi, Eleonora, Macaluso, Guido Maria, Bussolati, Ovidio, and Lumetti, Simone

Subjects
MACROPHAGES, DENTAL materials, BIOLOGICAL assay, TISSUE culture, MATERIALS testing
Abstract

Testing of dental materials when in contact with innate immune cells has been so far hindered by the lack of proper in vitro models. Human primary monocyte-derived macrophages (MDMs) would be an excellent option to this aim. However, the inability to detach them from the tissue culture plates contrast the possibility to culture them on biomaterials. The goal of the present work is to present and validate an innovative protocol to obtain MDMs from peripheral blood monocytes, and to reseed them in contact with biomaterials without altering their viability and phenotype. We differentiated MDMs on ultra-low attachment tissue culture plastics and recovered them with specific detachment solution in order to be reseeded on a secondary substrate. Therefore, using biological assays (RT-PCR, Western blot, and immunofluorescence) we compared their phenotype to MDMs differentiated on standard culture plates. Transferred MDMs keep their differentiated M0 resting state, as well as the ability to be polarized into M1 (pro-inflammatory) or M2 (anti-inflammatory) macrophages. These data provide the dental material research community the unprecedented possibility to investigate the immunomodulatory properties of biomaterials for dental application. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Formation of hollow silver nanoparticles under irradiation with ultrashort laser pulses

Author

Sánchez-Pérez, Francisco, Borrell-Grueiro, Olivia, Casasnovas-Melián, Alfredo, Ramos-Ramos, Diego J., Guerrero-Martínez, Andrés, Bañares, Luis, Prada, Alejandro, Valencia, Felipe J., Kohanoff, Jorge, Crespillo, Miguel L., Olivares, José, Rivera, Antonio, and Peña-Rodríguez, Ovidio

Abstract

We have studied the formation of cavities in spherical silver nanoparticles embedded in silica, irradiated with fs laser pulses that produce an intense electronic excitation. Experimentally determined aspect ratio, i.e. the ratio between the cavity and nanoparticle size, for hollow structures formed under different irradiation conditions shows a very good agreement with values obtained by means of atomistic simulations. According to the predictions of the atomistic model, one can produce at will hollow silver nanoparticles with cavities of tailored dimensions, having an accurate control. Hence, laser irradiation can be used to control and design the optical response by tuning the localized surface plasmon resonances of the hollow nanoparticles.

Published
2024
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31. Revisiting the Role of Seed Size for the Synthesis of Highly Uniform Sub-10 nm Length Gold Nanorods

Author

González-Rubio, Guillermo, Llombart, Pablo, Zhou, Jian, Geiss, Henry, Peña-Rodríguez, Ovidio, Gai, Huiyu, Ni, Bing, Rosenberg, Rose, and Cölfen, Helmut

Abstract

Despite the advances achieved in the past decade in the seed-mediated synthesis of colloidal single-crystal gold nanorods (Au NRs), the seed size role in the Au NR formation is not fully understood. Moreover, although the anisotropic growth of single-crystal seeds typically occurs at sizes between 4 and 6 nm, synthesizing high-quality Au NRs with sub-10 nm lengths remains challenging. We investigated herein the effect of seed dimensions on the silver-assisted seed-mediated growth of single-crystal Au NRs with lengths below 10 nm in the presence of hexadecyltrimethylammonium bromide (CTAB). A strong relationship was found between the seed dimensions and the yield of Au NR formation, where 3.1 nm seeds displayed an optimal anisotropic grow behavior. This effect could be related to the different abilities of CTAB micelles to passivate gold seeds with distinct dimensions, as suggested by molecular dynamic experiments. Compared with the 1–2 nm seeds traditionally used in the Au NR synthesis, the enhanced ability of 3.1 nm seeds to evolve anisotropically facilitates the growth of high-quality Au NRs with sub-10 nm lengths in an unprecedented manner. An optimal concentration of silver was also critical for the efficient evolution of 3.1 nm seeds into sub-10 nm Au NRs. Moreover, the synthesized small Au NRs were used as anisotropic seeds to fabricate sub-10 nm diameter Au NRs with tunable aspect ratios and core–shell electrocatalysts. The insight gained on the role of seed size enabled us to develop an advanced reproducible and scalable route for the synthesis of Au NRs with sub-10 nm lengths.

Published
2024
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32. Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Author

Dharmayat, Kanika Inamdar, Vallejo-Vaz, Antonio J., Stevens, Christophe A.T., Brandts, Julia M., Lyons, Alexander R.M., Groselj, Urh, Abifadel, Marianne, Aguilar-Salinas, Carlos A., Alhabib, Khalid, Alkhnifsawi, Mutaz, Almahmeed, Wael, Alnouri, Fahad, Alonso, Rodrigo, Al-Rasadi, Khalid, Ashavaid, Tester F., Banach, Maciej, Béliard, Sophie, Binder, Christoph, Bourbon, Mafalda, Chlebus, Krzysztof, Corral, Pablo, Cruz, Diogo, Descamps, Olivier S., Drogari, Euridiki, Durst, Ronen, Ezhov, Marat V., Genest, Jacques, Harada-Shiba, Mariko, Holven, Kirsten B., Humphries, Steve E., Khovidhunkit, Weerapan, Lalic, Katarina, Laufs, Ulrich, Liberopoulos, Evangelos, Roeters van Lennep, Jeanine, Lima-Martinez, Marcos Miguel, Lin, Jie, Maher, Vincent, März, Winfried, Miserez, André R., Mitchenko, Olena, Nawawi, Hapizah, Panayiotou, Andrie G., Paragh, György, Postadzhiyan, Arman, Reda, Ashraf, Reiner, Željko, Reyes, Ximena, Sadiq, Fouzia, Sahebkar, Amirhossein, Schunkert, Heribert, Shek, Aleksandr B., Stroes, Eric, Su, Ta-Chen, Subramaniam, Tavintharan, Susekov, Andrey, Vázquez Cárdenas, Alejandra, Huong Truong, Thanh, Tselepis, Alexandros D., Vohnout, Branislav, Wang, Luya, Yamashita, Shizuya, Al-Sarraf, Ahmad, Al-Sayed, Nasreen, Davletov, Kairat, Dwiputra, Bambang, Gaita, Dan, Kayikcioglu, Meral, Latkovskis, Gustavs, Marais, A. David, Thushara Matthias, Anne, Mirrakhimov, Erkin, Nordestgaard, Børge G., Petrulioniene, Zaneta, Pojskic, Belma, Sadoh, Wilson, Tilney, Myra, Tomlinson, Brian, Tybjærg-Hansen, Anne, Viigimaa, Margus, Catapano, Alberico L., Freiberger, Tomas, Hovingh, G. Kees, Mata, Pedro, Soran, Handrean, Raal, Frederick, Watts, Gerald F., Schreier, Laura, Bañares, Virginia, Greber-Platzer, Susanne, Baumgartner-Kaut, Margot, de Gier, Charlotte, Dieplinger, Hans, Höllerl, Florian, Innerhofer, Reinhold, Karall, Daniela, Lischka, Julia, Ludvik, Bernhard, Mäser, Martin, Scholl-Bürgi, Sabine, Thajer, Alexandra, Toplak, Hermann, Demeure, Fabian, Mertens, Ann, Balligand, Jean-Luc, Stephenne, Xavier, Sokal, Etienne, Petrov, Ivo, Goudev, Assen, Nikolov, Fedya, Tisheva, Snejana, Yotov, Yoto, Tzvetkov, Ivajlo, Hegele, Robert A, Gaudet, Daniel, Brunham, Liam, Ruel, Isabelle, McCrindle, Brian, Cuevas, Ada, Perica, Dražen, Symeonides, Phivos, Trogkanis, Efstratios, Kostis, Andreas, Ioannou, Andreas, Mouzarou, Angeliki, Georgiou, Anthoula, Stylianou, Andreas, Miltiadous, George, Iacovides, Paris, Deltas, Constantinos, Vrablik, Michal, Urbanova, Zuzana, Jesina, Pavel, Tichy, Lukas, Hyanek, Josef, Dvorakova, Jana, Cepova, Jana, Sykora, Josef, Buresova, Kristyna, Pipek, Michal, Pistkova, Eva, Bartkova, Ivana, S, Astrid, Toukalkova, Lenka, Spenerova, Michaela, Maly, Jan, Benn, Marianne, Bendary, Ahmed, Elbahry, Atef, Ferrières, Jean, Ferrieres, Dorota, Peretti, Noel, Bruckert, Eric, Gallo, Antonio, Valero, René, Mourre, Florian, Aouchiche, Karine, Reynaud, Rachel, Tounian, Patrick, Lemale, Julie, Boccara, Franck, Moulin, Philippe, Charrières, Sybil, Di Filippo, Mathilde, Cariou, Bertrand, Paillard, François, Dourmap, Caroline, Pradignac, Alain, Verges, Bruno, Simoneau, Isabelle, Farnier, Michel, Cottin, Yves, Yelnik, Cecile, Hankard, Regis, Schiele, François, Durlach, Vincent, Sultan, Ariane, Carrié, Alain, Rabès, Jean-Pierre, Sanin, Veronika, Schmieder, Roland, Ates, Sara, Rizos, Christos V., Skoumas, Ioannis, Tziomalos, Konstantinos, Rallidis, Loukianos, Kotsis, Vasileios, Doumas, Michalis, Skalidis, Emmanouil, Kolovou, Genovefa, Kolovou, Vana, Garoufi, Anastasia, Koutagiar, Iosif, Polychronopoulos, Georgios, Kiouri, Estela, Antza, Christina, Zacharis, Evangelos, Attilakos, Achilleas, Sfikas, George, Koumaras, Charalambos, Anagnostis, Panagiotis, Anastasiou, Georgia, Liamis, George, Adamidis, Petros-Spyridon, Milionis, Haralambos, Lambadiari, Vaia, Stabouli, Stella, Filippatos, Theodosios, Mollaki, Vicky, Tsaroumi, Anastasia, Lamari, Frida, Proyias, Pavlos, Harangi, Mariann, Reddy, Lakshmi Lavanya, Shah, Swarup A. V, Ponde, Chandrashekhar K., Dalal, Jamshed J., Sawhney, Jitendra P.S., Verma, Ishwar C., Hosseini, Susan, Jamialahmadi, Tannaz, Alareedh, Mohammed, Shaghee, Foaad, Rhadi, Sabah Hasan, Abduljalal, Maryam, Alfil, Sarmad, Kareem, Huda, Cohen, Hofit, Leitersdorf, Eran, Schurr, Daniel, Shpitzen, Shoshi, Arca, Marcello, Averna, Maurizio, Bertolini, Stefano, Calandra, Sebastiano, Tarugi, Patrizia, Casula, Manuela, Galimberti, Federica, Gazzotti, Marta, Olmastroni, Elena, Sarzani, Riccardo, Ferri, Claudio, Repetti, Elena, Giorgino, Francesco, Suppressa, Patrizia, Bossi, Antonio Carlo, Borghi, Claudio, Muntoni, Sandro, Cipollone, Francesco, Scicali, Roberto, Pujia, Arturo, Passaro, Angelina, Berteotti, Martina, Pecchioli, Valerio, Pisciotta, Livia, Mandraffino, Giuseppe, Pellegatta, Fabio, Mombelli, Giuliana, Branchi, Adriana, Fiorenza, Anna Maria, Pederiva, Cristina, Werba, José Pablo, Parati, Gianfranco, Nascimbeni, Fabio, Iughetti, Lorenzo, Fortunato, Giuliana, Cavallaro, Raimondo, Iannuzzo, Gabriella, Calabrò, Paolo, Cefalù, Angelo Baldassare, Capra, Maria Elena, Zambon, Alberto, Pirro, Matteo, Sbrana, Francesco, Trenti, Chiara, Minicocci, Ilenia, Federici, Massimo, Del Ben, Maria, Buonuomo, Paola Sabrina, Moffa, Simona, Pipolo, Antonio, Citroni, Nadia, Guardamagna, Ornella, Lia, Salvatore, Benso, Andrea, Biolo, Gianni Biolo, Maroni, Lorenzo, Lupi, Alessandro, Bonanni, Luca, Rinaldi, Elisabetta, Zenti, Maria Grazia, Masuda, Daisaku, Mahfouz, Linda, Jambart, Selim, Ayoub, Carine, Ghaleb, Youmna, Kasim, Noor Alicezah Mohd, Nor, Noor Shafina Mohd, Al-Khateeb, Alyaa, Kadir, Siti Hamimah Sheikh Abdul, Chua, Yung-An, Razman, Aimi Zafira, Nazli, Sukma Azureen, Ranai, Norashikin Mohd, Latif, Ahmad Zubaidi Abd, Torres, María Teresa Magaña, Mehta, Roopa, Martagon, Alexandro J., Ramirez, Gabriela A. Galan, Antonio-Villa, Neftali Eduardo, Vargas-Vazquez, Arsenio, Elias-Lopez, Daniel, Retana, Gustavo Gonzalez, Encinas, Bethsabel Rodriguez, Macias, Jose J. Ceballos, Zazueta, Alejandro Romero, Alvarado, Rocio Martinez, Portano, Julieta D. Morales, Lopez, Humberto Alvares, Sauque-Reyna, Leobardo, Gomez Herrera, Laura G., Simental Mendia, Luis E., Aguilar, Humberto Garcia, Cooremans, Elizabeth Ramirez, Aparicio, na, Zubieta, Victoria Mendoza, Gonzalez, Perla A. Carrillo, Ferreira-Hermosillo, Aldo, Portilla, Nacu Caracas, Dominguez, Guadalupe Jimenez, Garcia, Alinna Y. Ruiz, Arriaga Cazares, Hector E., Gonzalez Gonzalez, Jesus R., Mendez Valencia, Carla V., Padilla Padilla, Francisco G., Prado, Ramon Madriz, De los Rios Ibarra, Manuel O., na, Acevedo Rivera, Karina J., Carrera, Ricardo Allende, Alvarez, Jose A., Amezcua Martinez, Jose C., Barrera Bustillo, Manuel de los Reyes, Vargas, Gonzalo Carazo, Chacon, Roberto Contreras, Figueroa Andrade, Mario H., Ortega, Ashanty Flores, Alcala, Hector Garcia, Garcia de Leon, Laura E., Guzman, Berenice Garcia, Garcia, no, Garnica Cuellar, Juan C., Gomez Cruz, Jose R., Garcia, Anell Hernandez, Holguin Almada, Jesus R., Herrera, Ursulo Juarez, Sobrevilla, Fabiola Lugo, Rodriguez, Eduardo Marquez, Sibaja, Cristina Martinez, Medrano Rodriguez, Alma B., Morales Oyervides, Jose C., Perez Vazquez, Daniel I., Reyes Rodriguez, Eduardo A., Osorio, Ma. Ludivina Robles, Saucedo, Juan Rosas, Tamayo, Margarita Torres, Valdez Talavera, Luis A., Vera Arroyo, Luis E., Zepeda Carrillo, Eloy A., Galema-Boers, Annette, Weigman, Albert, Bogsrud, Martin P., Malik, Munir, Shah, Saeedullah, Khan, Sabeen Abid, Rana, Muhammad Asim, Batool, Hijab, Starostecka, Ewa, Konopka, Agnieszka, Lewek, Joanna, Bielecka-Dąbrowa, Agata, Gach, Agnieszka, Jóźwiak, Jacek, Pajkowski, Marcin, Romanowska-Kocejko, Marzena, Żarczyńska-Buchowiecka, Marta, Hellmann, Marcin, Chmara, Magdalena, Wasąg, Bartosz, Parczewska, Aleksandra, Gilis-Malinowska, Natasza, Borowiec-Wolna, Justyna, Stróżyk, Aneta, Michalska-Grzonkowska, Aleksandra, Chlebus, Izabela, Kleinschmidt, Mariola, Wojtecka, Agnieszka, Zdrojewski, Tomasz, Myśliwiec, Małgorzata, Hennig, Matylda, Medeiros, Ana Margarida, Alves, Ana Catarina, Almeida, Ana Filipa, Lopes, Andreia, Guerra, António, Bilhoto, Carla, Simões, Fernando, Silva, Francisco, Lobarinhas, Goreti, Gama, Guida, Palma, Isabel, Salgado, José Miguel, Matos, Luísa Diogo, Moura, Márcio de, Virtuoso, Maria João, Tavares, Mónica, Ferreira, Patrícia, Pais, Patrícia, Garcia, Paula, Coelho, Raquel, Ribeiro, Raquel, Correia, Susana, Sadykova, Dinara, Slastnikova, Evgenia, Alammari, Dalal, Mawlawi, Horia Ahmed, Alsahari, Atif, Khudary, Alia Abdullah, Alrowaily, Nawal Lafi, Rajkovic, Natasa, Popovic, Ljiljana, Singh, Sandra, Rasulic, Iva, Petakov, Ana, Lalic, Nebojsa M., Peng, Fabian Kok, Vasanwala, Rashida Farhan, Venkatesh, Sreedharan Aravind, Raslova, Katarina, Fabryova, Lubomira, Nociar, Jan, Šaligova, Jana, Potočňáková, Ludmila, Kozárová, Miriam, Varga, Tibor, Kadurova, Michaela, Debreova, Marianna, Novodvorsky, Peter, Gonova, Katarina, Klabnik, Alexander, Buganova, Ingrid, Battelino, Tadej, Bizjan, Barbara Jenko, Debeljak, Marusa, Kovac, Jernej, Mlinaric, Matej, Molk, Neza, Sikonja, Jaka, Sustar, Ursa, Podkrajsek, Katarina Trebusak, Muñiz-Grijalvo, Ovidio, Díaz-Díaz, Jose Luis, de Andrés, Raimundo, Fuentes-Jiménez, Francisco, Blom, Dirk, Miserez, Eleonore B., Shipton, Janine L., Ganokroj, Poranee, Futema, Marta, Ramaswami, Uma, Alieva, Rano B., Fozilov, Khurshid G., Khoshimov, Shavkat U., Nizamov, Ulugbek I., Abdullaeva, Guzal J., Kan, Liliya E., Abdullaev, Alisher A., Zakirova, Daria V., Do, Doan-Loi, Nguyen, Mai-Ngoc-Thi, Kim, Ngoc-Thanh, Le, Thanh-Tung, Le, Hong-An, Santos, Raul, and Ray, Kausik K.

Abstract

Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies.

Published
2024
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33. Sticky Brownian motions on star graphs

Author

Bonaccorsi, Stefano and D’Ovidio, Mirko

Abstract

This paper is concerned with the construction of Brownian motions and related stochastic processes in a star graph, which is a non-Euclidean structure where some features of the classical modeling fail. We propose a probabilistic construction of the Sticky Brownian motion by slowing down the Brownian motion when in the vertex of the star graph. Later, we apply a random change of time to the previous construction, which leads to a trapping phenomenon in the vertex of the star graph, with characterization of the trap in terms of a singular measure Φ. The process associated to this time change is described here and, moreover, we show that it defines a probabilistic representation of the solution to a heat equation type problem on the star graph with non-local dynamic conditions in the vertex that can be written in terms of a Caputo-Džrbašjan fractional derivative defined by the singular measure Φ. Extensions to general graph structures can be given by applying to our results a localisation technique.

Published
2024
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34. De-escalation of dual antiplatelet therapy for patients with acute coronary syndrome after percutaneous coronary intervention: a systematic review and network meta-analysis

Author

De Filippo, Ovidio, Piroli, Francesco, Bruno, Francesco, Bocchino, Pier Paolo, Saglietto, Andrea, Franchin, Luca, Angelini, Filippo, Gallone, Guglielmo, Rizzello, Giulia, Ahmad, Mahmood, Gasparini, Mauro, Chatterjee, Saurav, De Ferrari, Gaetano Maria, and D'Ascenzo, Fabrizio

Abstract

ObjectivesTo compare dual antiplatelet therapy (DAPT) de-escalation with five alternative DAPT strategies in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).DesignWe conducted a systematic review and network meta-analysis (NMA). Parallel-arm randomised controlled trials (RCTs) comparing DAPT strategies were included and arms of interest were compared via NMA. Partial ranking of each identified arm and for each investigated endpoint was also performed.Setting and participantsAdult patients with ACS (≥18 years) undergoing PCI with indications for DAPT.Search methodsA comprehensive search covered several databases (PubMed, Embase, Cochrane Central, MEDLINE, Conference Proceeding Citation Index-Science) from inception to 15 October 2023. Medical subject headings and keywords related to ACS, PCI and DAPT interventions were used. Reference lists of included studies were screened. Clinical trials registers were searched for ongoing or unpublished trials.InterventionsSix strategies were assessed: T1 arm: acetylsalicylic acid (ASA) and prasugrel for 12 months; T2 arm: ASA and low-dose prasugrel for 12 months; T3 arm: ASA and ticagrelor for 12 months; T4 arm: DAPT de-escalation (ASA+P2Y12 inhibitor for 1–3 months, then single antiplatelet therapy with potent P2Y12 inhibitor or DAPT with clopidogrel); T5 arm: ASA and clopidogrel for 12 months; T6 arm: ASA and clopidogrel for 3–6 months.Main outcome measuresPrimary outcome: Cardiovascular mortality. Secondary outcomes: bleeding events (all, major, minor), stent thrombosis (ST), stroke, myocardial infarction (MI), all-cause mortality, major adverse cardiovascular events (MACE).Results23 RCTs (75 064 patients with ACS) were included. No differences in cardiovascular mortality, all-cause death, recurrent MI or MACE were found when the six strategies were compared, although with different levels of certainty of evidence. ASA and clopidogrel for 12 or 3–6 months may result in a large increase of ST risk versus ASA plus full-dose prasugrel (OR 2.00, 95% CI 1.14 to 3.12, and OR 3.42, 95% CI 1.33 to 7.26, respectively; low certainty evidence for both comparisons). DAPT de-escalation probably results in a reduced risk of all bleedings compared with ASA plus full-dose 12-month prasugrel (OR 0.49, 95% CI 0.26 to 0.81, moderate-certainty evidence) and ASA plus 12-month ticagrelor (OR 0.52, 95% CI 0.33 to 0.75), while it may not increase the risk of ST. ASA plus 12-month clopidogrel may reduce all bleedings versus ASA plus full-dose 12-month prasugrel (OR 0.66, 95% CI 0.42 to 0.94, low certainty) and ASA plus 12-month ticagrelor (OR 0.70, 95% CI 0.52 to 0.89).ConclusionsDAPT de-escalation and ASA-clopidogrel regimens may reduce bleeding events compared with 12 months ASA and potent P2Y12 inhibitors. 3–6 months or 12-month aspirin-clopidogrel may increase ST risk compared with 12-month aspirin plus potent P2Y12 inhibitors, while DAPT de-escalation probably does not.

Published
2024
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35. Emotional characterization of children through a learning environment using learning analytics and AR-Sandbox

Author

Rodríguez, Andrés Ovidio Restrepo, Riaño, Maddyzeth Ariza, García, Paulo Alonso Gaona, Marín, Carlos Enrique Montenegro, Crespo, Rubén González, and Wu, Xing

Abstract

Identifying emotions experienced by students in a learning environment contributes to measuring the impact when technologies such as augmented reality (AR) are implemented in the educational field. The most frequent methods for collecting emotional metrics are questionnaires, surveys, and observations, but each of these processes lacks objectivity and veracity. For this reason, this study proposes, develops and tests a learning analytics scheme, based on the density-based spatial clustering of applications with noise algorithm, as a clustering technique with time series analysis, using the brain- computer interface device, Emotiv EPOC, as a way to collect emotional metrics. The above, in order to perform emotional behavior characterization by using AR in a learning environment through AR-Sandbox. The proposed method shows a clear inclination in the tendency of each emotion in each cluster, allowing classification of children during their interaction with the immersive environment, as well as the ability to distinguish each group of students.

Published
2024
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36. Outcomes of Heller Myotomy for Esophageal Achalasia: Lessons From a 48-Year Prospective Experience With 4 Different Techniques.

Author

Tassi, Valentina, Lugaresi, Marialuisa, Pilotti, Vladimiro, Bassi, Francesco, Daddi, Niccolò, D'Ovidio, Frank, Leiva-Juarez, Miguel M., and Mattioli, Sandro

Abstract

Objective: To provide information on long-term outcomes of Heller myotomy for esophageal achalasia with or without an antireflux fundoplication. Background: Since the adoption of the Heller myotomy, surgeons have modified the original technique in order to balance the cure of dysphagia and the consequent cardial incontinence. Methods: Totally, 470 patients underwent primary Heller myotomy between 1955 and 2020. A long abdominal myotomy (AM) was performed in 83 patients, the Ellis limited transthoracic myotomy (TM) in 30, the laparotomic Heller-Dor (L-HD) in 202, the videolaparoscopic Heller-Dor (VL-HD) in 155. The HD was performed under intraoperative manometric assessment. Starting on 1973 these patients underwent a prospective follow-up program of timed lifelong clinical, radiological, endoscopic evaluations. Results: Median follow-up time was 23.06 years [interquantile range (IQR): 15.04–32.06] for AM, 29.22 years (IQR: 13.46–40.17) for TM, 14.85 years (IQR: 11.05–21.56) for L-HD and 7.51 years (IQR: 3.25–9.60) for VL-HD. In AM, relapse of dysphagia occurred in 25/71 (35.21%), in TM in 11/30 (36.66%), in LH-D in 10/201 (4.97%), in VL-HD in 3/155 (1.93%). Erosive-ulcerative esophagitis was diagnosed for AM in 28.16%, for TM in 30%, for L-HD in 8.45%, for VL-HD in 2.58%. Overall, the outcome was satisfactory in 52.11% for AM, 41.9% for TM, 89.05% for L-HD, 96.12% for VL-HD. Conclusions: The Dor fundoplication drastically reduces postmyotomy gastroesophageal reflux. The Heller-Dor operation is a competitive option for the cure of esophageal achalasia if this operation is performed according to the rules of surgical physiology learned by means of intraoperative manometry. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Unilateral segmental uterine horn hypoplasia with fallopian tube aplasia in a guinea pig (Caviaporcellus).

Author

Wernick, Morena B., D'Ovidio, Dario, Ruetten, Maja, and Howard, Judith

Subjects
GUINEA pigs, FALLOPIAN tubes, HUMAN abnormalities, WEIGHT gain, CARDIAC arrest, AUTOPSY
Abstract

A 2-year-3-month-old female guinea pig (Cavia porcellus) was referred for lethargy, weight gain and severe abdominal pain. Ultrasound examination revealed thickening and enlargement of the left uterine horn and an unremarkable right uterine horn. The animal died during ovariohysterectomy due to respiratory and cardiac arrest. Necropsy revealed unilateral segmental uterine horn hypoplasia and aplasia of the fallopian tube of the corresponding side. This is the first report of a congenital uterine malformation in the guinea pig and we describe the clinical and pathological presentation of segmental uterine horn hypoplasia and fallopian tube aplasia. Congenital uterine malformations are rare in guinea pigs but should be considered as differential diagnoses for the more common acquired uteropathies. [ABSTRACT FROM AUTHOR]

Published
2024
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39. From Multi- to Single-Hollow Trimetallic Nanocrystals by Ultrafast Heating

Author

Manzaneda-González, Vanesa, Jenkinson, Kellie, Peña-Rodríguez, Ovidio, Borrell-Grueiro, Olivia, Triviño-Sánchez, Sergio, Bañares, Luis, Junquera, Elena, Espinosa, Ana, González-Rubio, Guillermo, Bals, Sara, and Guerrero-Martínez, Andrés

Abstract

Metal nanocrystals (NCs) display unique physicochemical features that are highly dependent on nanoparticle dimensions, anisotropy, structure, and composition. The development of synthesis methodologies that allow us to tune such parameters finely emerges as crucial for the application of metal NCs in catalysis, optical materials, or biomedicine. Here, we describe a synthetic methodology to fabricate hollow multimetallic heterostructures using a combination of seed-mediated growth routes and femtosecond-pulsed laser irradiation. The envisaged methodology relies on the coreduction of Ag and Pd ions on gold nanorods (Au NRs) to form Au@PdAg core–shell nanostructures containing small cavities at the Au–PdAg interface. The excitation of Au@PdAg NRs with low fluence femtosecond pulses was employed to induce the coalescence and growth of large cavities, forming multihollow anisotropic Au@PdAg nanostructures. Moreover, single-hollow alloy AuPdAg could be achieved in high yield by increasing the irradiation energy. Advanced electron microscopy techniques, energy-dispersive X-ray spectroscopy (EDX) tomography, X-ray absorption near-edge structure (XANES) spectroscopy, and finite differences in the time domain (FDTD) simulations allowed us to characterize the morphology, structure, and elemental distribution of the irradiated NCs in detail. The ability of the reported synthesis route to fabricate multimetallic NCs with unprecedented hollow nanostructures offers attractive prospects for the fabrication of tailored high-entropy alloy nanoparticles.

Published
2023
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40. Physicochemical Characterization of a Biomimetic, Elastin-Inspired Polypeptide with Enhanced Thermoresponsive Properties and Improved Cell Adhesion

Author

Bandiera, Antonella, Colomina - Alfaro, Laura, Sist, Paola, Gomez d’Ayala, Giovanna, Zuppardi, Federica, Cerruti, Pierfrancesco, Catanzano, Ovidio, Passamonti, Sabina, and Urbani, Ranieri

Abstract

Genetic engineering allows fine-tuning and controlling protein properties, thus exploiting the new derivatives to obtain novel materials and systems with improved capacity to actively interact with biological systems. The elastin-like polypeptides are tunable recombinant biopolymers that have proven to be ideal candidates for realizing bioactive interfaces that can interact with biological systems. They are characterized by a thermoresponsive behavior that is strictly related to their peculiar amino acid sequence. We describe here the rational design of a new biopolymer inspired by elastin and the comparison of its physicochemical properties with those of another already characterized member of the same protein class. To assess the cytocompatibility, the behavior of cells of different origins toward these components was evaluated. Our study shows that the biomimetic strategy adopted to design new elastin-based recombinant polypeptides represents a versatile and valuable tool for the development of protein-based materials with improved properties and advanced functionality.

Published
2023
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42. Impact of Right Ventricular Pacing in Patients With TAVR Undergoing Permanent Pacemaker Implantation.

Author

Bruno, Francesco, Munoz Pousa, Isabel, Saia, Francesco, Vaira, Matteo Pio, Baldi, Enrico, Leone, Pier Pasquale, Cabanas-Grandio, Pilar, Corcione, Nicola, Spinoni, Enrico Guido, Annibali, Gianmarco, Russo, Caterina, Ziacchi, Matteo, Caruzzo, Carlo Alberto, Ferlini, Marco, Lanzillo, Giuseppe, De Filippo, Ovidio, Dusi, Veronica, Gallone, Guglielmo, Castagno, Davide, and Patti, Giuseppe

Abstract

Long-term right ventricular pacing (VP) has been related to negative left ventricular remodeling and heart failure (HF), but there is a lack of evidence regarding the prognostic impact on transcatheter aortic valve replacement (TAVR) patients. The aim of the PACE-TAVI registry is to evaluate the association of high percentage of VP with adverse outcomes in patients with pacemaker implantation after TAVR. PACE-TAVI is an international multicenter registry of all consecutive TAVR patients who underwent permanent pacemaker implantation for conduction disturbances in the first 30 days after the procedure. Patients were divided into 2 subgroups according to the percentage of VP (<40% vs ≥40%) at pacemaker interrogation. The primary endpoint was the composite of cardiovascular mortality or hospitalization for HF. A total of 377 patients were enrolled, 158 with VP <40% and 219 with VP ≥40%. After multivariable adjustment, VP ≥40% was associated with a higher incidence of the primary endpoint (HR: 2.76; 95% CI: 1.39-5.51; P = 0.004), first HF hospitalization (HR: 3.37; 95% CI: 1.50-7.54; P = 0.003), and cardiovascular death (HR: 3.77; 95% CI: 1.02-13.88; P = 0.04), while the incidence of all-cause death was not significantly different (HR: 2.17; 95% CI: 0.80-5.90; P = 0.13). Patients with VP ≥ 40% showed a higher New York Heart Association functional class both at 1 year (P = 0.009) and at last available follow-up (P = 0.04) and a nonsignificant reduction of left ventricular ejection fraction (P = 0.18) on 1-year echocardiography, while patients with VP <40% showed significant improvement (P = 0.009). In TAVR patients undergoing permanent pacemaker implantation, a high percentage of right VP at follow-up is associated with an increased risk for cardiovascular death and HF hospitalization. These findings suggest the opportunity to minimize right VP through dedicated algorithms in post-TAVR patients without complete atrioventricular block and to evaluate a more physiological VP modality in patients with persistent complete atrioventricular block. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2023
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43. Impact of Applied Voltage on Threshold Voltage Instability in Active Load Thin-Film a-IGZO Inverters

Author

Garcia, Rodolfo, Rodriguez-Lopez, Ovidio, Rocha-Flores, Pedro E., Mejia, Israel, Hernandez-Como, Norberto, Voit, Walter E., and Gutierrez-Heredia, Gerardo

Abstract

This work presents an analysis and modeling of the electrical stress effects caused by different voltages on a logic inverter device circuit based on thin-film transistor (TFT) technology. The study includes the characterization of single indium-gallium-zinc oxide (IGZO) TFTs and inverters with an active load configuration to investigate the behavior of their threshold voltage ( ${V}_{\text {TH}}{)}$ under various bias voltages. Additionally, an analytical model is used to quantify the impact of electrical stress on the trapping parameters of the dielectric–semiconductor interface. The model demonstrates that the charged trapped concentration increases exponentially with the applied voltage bias, resulting in a significant initial shift in ${V}_{\text {TH}}$ . Importantly, this analytical model allows the assessment of the electrical stress effect on TFT-based circuits. The findings can inform the determination of a maximum applied voltage bias based on the desired threshold voltage. Furthermore, the model facilitates the estimation of circuit reliability and lifetime by considering the polarization time under different applied voltage bias conditions.

Published
2023
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46. De invisibles a hipervisibilizados. Jóvenes de familias marginadas en una escuela urbana.

Author

Cárcamo-Hernández, Ovidio

Abstract

Copyright of Revista de Antropología Social is the property of Universidad Complutense de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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47. Contribución de las inversiones en recursos humanos según el tipo de eficiencia técnica de la banca múltiple peruana.

Author

Castillo Inche, Lucia Karin, Tejada Portilla, Lourdes Belén, and Flores Gutiérrez, José Ovidio

Subjects
BANKING industry, HUMAN resources departments, LONGITUDINAL method
Abstract

Copyright of Acta Universitaria is the property of Universidad de Guanajuato/Acta Universitaria and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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49. Nanoemulsions Embedded in Alginate Beads as Bioadhesive Nanocomposites for Intestinal Delivery of the Anti-Inflammatory Drug Tofacitinib

Author

Andretto, Valentina, Taurino, Giuseppe, Guerriero, Giulia, Guérin, Hanäé, Lainé, Emmanuelle, Bianchi, Massimiliano G., Agusti, Géraldine, Briançon, Stéphanie, Bussolati, Ovidio, Clayer-Montembault, Alexandra, and Lollo, Giovanna

Abstract

Oral administration of nanoparticles (NPs) is a promising strategy to overcome solubility and stability issues of many active compounds. However, this route faces major obstacles related to the hostile gastrointestinal (GI) environment, which impairs the efficacy of orally administered nanomedicines. Here, we propose nanocomposites as a promising approach to increase the retention time of NPs in the intestinal tract by using bio- and mucoadhesive matrixes able to protect the cargo until it reaches the targeted area. A microfluidic-based approach has been applied for the production of tailored nanoemulsions (NEs) of about 110 nm, used for the encapsulation of small hydrophobic drugs such as the anti-inflammatory JAK-inhibitor tofacitinib. These NEs proved to be efficiently internalized into a mucus-secreting human intestinal monolayer of Caco-2/HT29-MTX cells and to deliver tofacitinib to subepithelial human THP-1 macrophage-like cells, reducing their inflammatory response. NEs were then successfully encapsulated into alginate hydrogel microbeads of around 300 μm, which were characterized by rheological experiments and dried to create a long-term stable system for pharmaceutical applications. Finally, ex vivoexperiments on excised segments of rats′ intestine proved the bioadhesive ability of NEs embedded in alginate hydrogels compared to free NEs, showing the advantage that this hybrid system can offer for the treatment of intestinal pathologies.

Published
2023
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50. Alirocumab and Coronary Atherosclerosis in Asymptomatic Patients with Familial Hypercholesterolemia: The ARCHITECT Study

Author

Pérez de Isla, Leopoldo, Díaz-Díaz, Jose L., Romero, Manuel J., Muñiz-Grijalvo, Ovidio, Mediavilla, Juan D., Argüeso, Rosa, Sánchez Muñoz-Torrero, Juan F., Rubio, Patricia, Álvarez-Baños, Pilar, Ponte, Paola, Mañas, Dolores, Suárez Gutierrez, Lorena, Cepeda, José María, Casañas, Marta, Fuentes, Francisco, Guijarro, Carlos, Ángel Barba, Miguel, Saltijeral Cerezo, Adriana, Padró, Teresa, and Mata, Pedro

Published
2023
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