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3. A multicentred phase III comparative study of two hormonal contraceptive preparations given once-a-month by intramuscular injection: I. Contraceptive efficacy and side effects

Author

Said, S., Sadek, W., Knoieif, A., Koetsawang, Suporn, Kiriwat, Orawan, Piboonmanee, Surat, Rivera, R., Alvarado, G., Juarez, M.A., Aguliar, S., Santiso, R., Contreras, C.F., Galichi, L.F., Guliora, M., Alzugaray, M.G., Hernandez, M.L., Gallardo, J.R., Affandi, B., Santoso, S.S.I., Jamil, R.S., Kazi, A., Kononova, E.S., Ailpov, V.I., Apeio, R., Hernardo, E.S., Benitez, I., Canto-de-Cetina, T., Cardenas, S., Polanco, L., Vera, L., Cravioto, M.-C., Hernandez, L., Fuziwara, J.L., Garza-Flores, J., Perez-Palacios, G., Oropeza, G., Mota, E., Zavaleta, E., Benagiano, G., Bastianelli, C., Diaz Infante-Ibarra, A., Castelo, C.J., Jimenez, R., Perez-Arocha, N., Lang-Prieto, J., Casas-Fernandez, J.A., Perez-Paz, H.M., Perez, M., Hernandez, A.R., Bustillo Tur, C., Kovacs, L., Koroszar, S., Bassol, S., Trujilio, A.M., Guzman-Serani, R., Israel, E., Hall, P.E., d’Arcangues, C., Busca, B., Macnin, D., Pinol, A., Schlagenhaft, F., and Hall, Peter E.

Abstract

Two once-a-month injectable contraceptive formulations, HRP112 (depot-medroxyprogesterone acetate, 25mg and estradiol cypionate, 5mg.) and HRP102 (norethisterone enantate, 50 mg and estradiol valerate, 5 mg,) were compared in two groups of women witn regard to effectiveness, reported complaints and reasons for discontinuation. A total of 2328 women were recruited into a seventeen-centre, randomized clinical trial. Follow-up was for a period of one year and resulted in a total of 10,969 women-months of experience of HRP112 and 10,608 women-months of experience with HRP102.

Published
1988
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