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65 results on '"Cosulich, A"'

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1. ASCERTAIN: An open-label, randomized, phase 1, window-of-opportunity study to investigate the biological effects of AZD5305 and darolutamide alone or in combination in men with prostate cancer eligible for radical prostatectomy.

2. Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration.

4. Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methyl-pyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.

5. Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

6. Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C

7. Discovery of (R)-8-(1-(3,5-Difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): A Potent andSelective Inhibitor of PI3Kβ and PI3Kδ for the Treatmentof PTEN-Deficient Cancers.

8. Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12Cwith Demonstrable CNS Penetration

9. Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

10. Diverse Heterocyclic Scaffolds as Allosteric Inhibitors of AKT.

11. Differential Branch Pulmonary Artery Regurgitant Fraction Is a Function of Differential Pulmonary Arterial Anatomy and Pulmonary Vascular Resistance.

12. Pre-Fontan cardiac magnetic resonance predicts post-Fontan length of stay and avoids ionizing radiation.

13. Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C

16. Azurin immobilisation on thiol covered Au(111)

17. A dominant negative form of IKK2 prevents suppression of apoptosis by the peroxisome proliferator nafenopin

18. A dominant negative form of IKK2 prevents suppression of apoptosis by the peroxisome proliferator nafenopin.

19. Performance evaluation of hyperbranched aramids as potential supports for protein immobilization

20. Biochemical and immunochemical characterization of hop-hornbeam (Ostrya Carpinifolia Scop.) pollen

21. Role of MAP kinase signalling pathways in the mode of action of peroxisome proliferators

22. Role of MAP kinase signalling pathways in the mode of action of peroxisome proliferators.

23. Apoptosis or plasma cell differentiation of CD38-positive B-chronic lymphocytic leukemia cells induced by cross-linking of surface IgM or IgD

24. Late apoptotic effects of taxanes on K562 erythroleukemia cells: Apoptosis is delayed upstream of caspase-3 activation

25. Apoptosis or plasma cell differentiation of CD38-positive B-chronic lymphocytic leukemia cells induced by cross-linking of surface IgM or IgD

26. Hyperbranched aramids by direct polyamidation of two reactant systems: Synthesis and properties

27. Suppression of apoptosis and induction of DNA synthesis in vitro by the phthalate plasticizers monoethylhexylphthalate (MEHP) and diisononylphthalate (DINP): a comparison of rat and human hepatocytes in vitro

28. Bcl-2 regulates amplification of caspase activation by cytochrome c

29. Systemic administration of autologous, alloactivated helper-enriched lymphocytes to patients with metastatic melanoma of the lung

30. Regulation of apoptosis by BH3 domains in a cell-free system

31. CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis

32. Isolation and Identification of Piperacillin Amide as an Impurity in Piperacillin

33. Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts.

34. Autoimmune thyroid disease: purification and phenotypic analysis of intrathyroid T cells

35. Effects of fluorinated inositols on the proliferation of Swiss 3T3 fibroblasts

37. Functional characterization of an antigen involved in an early step of T-cell activation.

38. A monoclonal anti-DC1 antibody selectivity inhibits the generation of effector T cells mediating specific cytolytic activity.

39. Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts

44. Genome-Wide Estrogen Receptor Activity in Breast Cancer

45. Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors

47. Capillary Gas Chromatographic–Mass Spectrometric Analysis of 15-Deoxy-16-hydroxy-16-vinylprostaglandin E2

49. The Structure and Synthesis of the Liver L. caseiFactor

50. Combination of dual mTORC1/2 inhibition and immune-checkpoint blockade potentiates anti-tumour immunity

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