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Objective The GERODIAB follow-up survey is the first French multi-centre, prospective, observational study designed to analyze the influence of glycaemic control on morbidity-mortality over 5 years in type 2 diabetic patients aged 70 years and over. This report analyses the factors associated with cognitive decline at inclusion. Patients and methods A total of 987 patients with well-maintained autonomy were consecutively included in 56 French diabetic centres. Cognition was systematically explored using the Mini-Mental State Examination (MMSE). Cognitive disorders were defined by previously known dementia and/or MMSE scores ≤ 24/30. Results were analyzed using the Kruskal–Wallis or the chi 2 tests. Multivariate analysis was a stepwise logistic regression. Results Two hundred and eighty-four patients (28.8%) had a cognitive disorder; they were older (78.4 ± 5 vs. 76.5 ± 4.8 year; P < .001) and were more frequently women (60.2 vs. 48.8%; P < .001). They had a similar duration of diabetes (17.6 ± 11.1 vs. 17.9 ± 10.7 years; P = .651), but a higher HbA 1c level (7.8 ± 1.5 vs. 7.5 ± 1.2%; P = .002). They were treated with insulin more often (65.1% vs. 54.3%; P = .002) and less often with metformin (40.1% vs. 52.3%; P < .001). In multivariate analysis, cognitive disorders were associated with age, gender and HbA 1c , successively (concordance 64.1%, P < .001). Of the complications of diabetes, cognitive impairment was associated with peripheral neuropathy (37.3 vs. 24.5%; P < .001), cerebrovascular involvement (20.8 vs. 13.8%; P = .007) and heart failure (14.1 vs. 8.5%; P = .009). Conclusion Cognitive disorders were associated with HbA 1c level and some complications of diabetes, suggesting similar pathological mechanisms. Systematic screening for cognitive impairment could be beneficial in elderly type 2 diabetic patients. [ABSTRACT FROM AUTHOR]

Copyright of Diabetes & Metabolism is the property of Masson Editeur and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

We present the case of a patient who was recently convicted for exhibitionism whose clinical assessment suggested undiagnosed Huntington's disease. We summarise the clinical characteristics, the genetics involved and the diagnostic difficulties which can be encountered. Finally, we discuss the implications of this diagnosis in forensic medicine. [ABSTRACT FROM AUTHOR]

A diagnosis of Alzheimer's disease (AD) is associated with an increased risk of unprovoked seizures. In this observational study, we analyzed first seizures in a sample of elderly subjects with AD hospitalized in an acute geriatric care unit. Only 2.5% of the hospitalized AD patients were admitted for a first seizure. The seizures are not necessarily symptomatic of AD. Symptomatic cause must be ruled out in order to classify the syndrome before introducing antiepileptic drugs (AEDs). In practice, only recurrent unprovoked seizures or symptomatic location- related epilepsy with a high risk of recurrence should be treated with AEDs. [ABSTRACT FROM AUTHOR]

Copyright of Diabetes & Metabolism is the property of Masson Editeur and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Diabetes & Metabolism is the property of Masson Editeur and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Diabetes & Metabolism is the property of Masson Editeur and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)