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8 results on '"Conley, Nicholas"'

1. Social Determinants of Health, Chronic Disease Management, and the Role of the Primary Care Provider—to Include Cardiovascular Disease, Cancer, Diabetes, Major Causes of Morbidity and Mortality as Affected by Social Determinants of Health

Author

Conley, Nicholas

Abstract

Despite advances in health science and medical technology, health outcomes continue to fall behind in certain communities. A recent study linking health outcomes to zip code may explain part of this disparity, social determinants of health. Although well known that patients in resource-poor environments have worse outcomes than patients with advantages, the exact reason for this disparity may not be so well known. This article aims to explore the physiologic basis for worsening disease states in patients with poor social determinants of health, as well as start a discussion surrounding possible screening and interventions that can be performed in a primary care office to promote patient health.

Published
2023
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2. A Pooled Case-only Analysis of Reproductive Risk Factors and Breast Cancer Subtype Among Black Women in the Southeastern United States.

Author

Sanderson, Maureen, Pal, Tuya, Beeghly-Fadiel, Alicia, Fadden, Mary Kay, Dujon, Steffie-Ann, Clinton, Chrystina, Jimenez, Cecilia, Davis, Jennifer, Fortune, Mieke, Thompson, Jasmine, Benson, Kiera, Conley, Nicholas, Reid, Sonya, Tezak, Ann, Xiao-Ou Shu, Wei Zheng, Blot, William J., and Lipworth, Loren

Abstract

Background: We investigated the association between reproductive risk factors and breast cancer subtype in Black women. On the basis of the previous literature, we hypothesized that the relative prevalence of specific breast cancer subtypes might differ according to reproductive factors. Methods: We conducted a pooled analysis of 2,188 (591 premenopausal, 1,597 postmenopausal) Black women with a primary diagnosis of breast cancer from four studies in the southeastern United States. Breast cancers were classified by clinical subtype. Case-only polytomous logistic regression models were used to estimate ORs and 95% confidence intervals (CI) for HER2+ and triple-negative breast cancer (TNBC) status in relation to estrogen receptor-positive (ER+)/HER2- status (referent) for reproductive risk factors. Results: Relative to women who had ER+/HER2- tumors, women who were age 19-24 years at first birth (OR, 1.78; 95% CI, 1.22-2.59) were more likely to have TNBC. Parous women were less likely to be diagnosed with HER2+ breast cancer and more likely to be diagnosed with TNBC relative to ER+/HER2- breast cancer. Postmenopausal parous women who breastfed were less likely to have TNBC [OR, 0.65 (95% CI, 0.43-0.99)]. Conclusions: This large pooled study of Black women with breast cancer revealed etiologic heterogeneity among breast cancer subtypes. Impact: Black parous women who do not breastfeed are more likely to be diagnosed with TNBC, which has a worse prognosis, than with ER+/HER2- breast cancer. [ABSTRACT FROM AUTHOR]

Published
2021
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3. A Selenium Analogue of Firefly D‐Luciferin with Red‐Shifted Bioluminescence Emission

Author

Conley, Nicholas R., Dragulescu‐Andrasi, Anca, Rao, Jianghong, and Moerner, W. E.

Abstract

A selenium analogueof amino‐D‐luciferin, aminoseleno‐D‐luciferin, is synthesized and shown to be a competent substrate for the firefly luciferase enzyme. It has a red‐shifted bioluminescence emission maximum at 600 nm (see scheme) and is suitable for bioluminescence imaging studies in living subjects.

Published
2012
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4. A Selenium Analogue of Firefly D‐Luciferin with Red‐Shifted Bioluminescence Emission

Author

Conley, Nicholas R., Dragulescu‐Andrasi, Anca, Rao, Jianghong, and Moerner, W. E.

Abstract

Ein Selenanalogonvon Amino‐D‐luciferin wurde synthetisiert und als vom Enzym Glühwürmchen‐Luciferase akzeptiertes Substrat identifiziert. Aminoseleno‐D‐luciferin hat ein rotverschobenes Emissionsmaximum der Biolumineszenz bei 600 nm (siehe Bild) und ist für Biolumineszenz‐Bildgebungsstudien in lebenden Organismen geeignet.

Published
2012
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5. Palladium‐Catalyzed Carbonylation of Diols to Cyclic Carbonates

Author

Pearson, David M., Conley, Nicholas R., and Waymouth, Robert M.

Abstract

The catalytic alkoxycarbonylation of 1,2‐diols by (neocuproine)palladium(II) acetate (neocuproine=2,9‐dimethyl‐1,10‐phenanthroline) or palladium(II) acetate/(−)‐sparteine using N‐chlorosuccinimide as the oxidant affords cyclic carbonates. The oxidative carbonylation of diols proceeds under mild conditions, requiring only 1 atm of carbon monoxide, and produces cyclic carbonates in moderate to good yields. Both 1,2‐ and 1,3‐diols can be carbonylated using (neocuproine)Pd(OAc)2and sodium dichloroisocyanuric acid, which serves as a competent oxidant and base for this system, to yield 5‐ and 6‐membered cyclic carbonates.

Published
2011
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6. Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma

Author

Purzner, Teresa, Purzner, James, Buckstaff, Taylor, Cozza, Giorgio, Gholamin, Sharareh, Rusert, Jessica M., Hartl, Tom A., Sanders, John, Conley, Nicholas, Ge, Xuecai, Langan, Marc, Ramaswamy, Vijay, Ellis, Lauren, Litzenburger, Ulrike, Bolin, Sara, Theruvath, Johanna, Nitta, Ryan, Qi, Lin, Li, Xiao-Nan, Li, Gordon, Taylor, Michael D., Wechsler-Reya, Robert J., Pinna, Lorenzo A., Cho, Yoon-Jae, Fuller, Margaret T., Elias, Joshua E., and Scott, Matthew P.

Abstract

Inhibitors of the kinase CK2 may halt the growth of an aggressive form of medulloblastoma.

Published
2018
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