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Real-life estimations of survival by stage in colorectal cancer are scanty. We estimated population-based net survival by pathological stage and location, and for rectal cancer by patterns of evolution according to clinical and pathological stage with regard to neoadjuvant therapy. Age-standardized net survival was estimated on 19,630 colorectal cancers diagnosed between 2009 and 2015. Five-year net survival was 64 % for colon and 62 % for rectal cancer. The highest absolute difference between colon and rectum was 12 % for stage II women aged 75 (91% vs. 79 %). Among patients with clinical stage III rectal cancer, 67 % no longer had pathological node involvement after neoadjuvant treatment. Survival was similar in clinical stage I, II or III and pathological stage III after neoadjuvant treatment and in pathological stage III without neoadjuvant treatment (between 67 % and 72 %). It ranged between 80 and 82 % in pathological stage II, without neoadjuvant treatment or with clinical stage I, II or III before neoadjuvant treatment. Survival ranged between 93 % and 95 % in pathological stage I, treated with surgery only or with clinical stage II or III before neoadjuvant treatment. Prognosis is associated with stage determined on surgical specimens rather than stage at the initial workup. [ABSTRACT FROM AUTHOR]

Malnutrition is associated with the prognosis of malignant disease. The geriatric nutritional risk index (GNRI), based on serum albumin (ALB) levels and the present and ideal body weight, is a simple screening tool with which to predict the risk of malnutrition and mortality in patients. We hypothesised that nutritional markers could predict the prognosis of patients with oral squamous cell carcinoma (OSCC). The primary predictor variable was the GNRI score and the primary outcome variable was overall survival (OS). Univariate and multivariate analyses were performed using a Cox proportional hazard model to identify independent prognostic factors. The sample comprised 155 patients, of whom 17 presented with a low GNRI score (≤98) and 138 with a high GNRI score (≥ 98). There was a significant difference in OS when patients were stratified according to GNRI scores, with OS rates of 29.2% and 76.4% for scores of 98 and under and scores of over 98, respectively (p < 0.001). Univariate analyses showed that OS was significantly associated with GNRI score, age, T classification, N classification, stage, body mass index (BMI), prognostic nutrition index, and ALB levels. Analysis identified three independent predictive factors for OS: age (hazard ratio (HR) 2.184; 95% confidence interval (CI) 1.119 to 4.261; p = 0.022), stage (HR 2.684; 95% CI 1.457 to 5.367; p = 0.011), and GNRI score (HR 4.559; 95% CI 2.172 to 9.570; p <0.001). The results suggest that the GNRI score (>98 vs ≤98) is a good prognostic marker in patients with OSCC, along with age and stage. [ABSTRACT FROM AUTHOR]

To observe the clinical efficacy of fire needle combined with filiform needle for different clinical stage frozen shoulders, and to choose the best treatment opportunity for clinical treatment of frozen shoulder. 120 patients with frozen shoulders who met the inclusion criteria were numbered according to the visiting order. They were randomized into control group (60 cases) and treatment group (60 cases) according to the random number table. Both groups were treated with filiform needles once every other day and 3 times a week, and a course of treatment included 6 times and 2 courses were taken. The treatment group was treated by applying a fire needling point bloodletting on the local tender points once a week. Jiānyú (肩髃 LI 15), Jiānliáo (肩髎 TE 14), Jiānzhēn (肩贞 SI 9), Tiáokŏu (条口 ST 38), and local tender points were taken according to different meridian pains. The clinical efficacy of the frozen shoulder patients in the two groups in different clinical stages was compared. The evaluation indicators were scores of pain, joint activity range and activities of daily living, as well as clinical efficacy of traditional Chinese medicine. After treatment, the total scores of hundred-mark five-grade in both groups were significantly higher than those before treatment, and the differences were statistically significant (Treatment group 82.02 ± 14.23 vs 43.37 ± 22.10, Control group 66.80 ± 18.98 vs 42.67 ± 23.03, both P < 0.01), and the total score of the treatment group was significantly higher than the control group (P < 0.01). The hundred-mark five-grade assessment scores after treatment in the treatment group during the frozen stage were significantly higher than the control group (77.2 ± 14.40 vs 68.43 ± 16.94, P < 0.01); as to the clinical efficacy, the total effective rate of the treatment group was higher than the control group, and the difference was statistically significant (91.67% vs 76.67%, P < 0.01); The total effective rate of the control group in the acute stage and functional recovery stage was compared with the frozen stage, and the difference was statistically significant (100% vs 60%, P < 0.01), and there was no significant difference between each phase of the treatment group (P > 0.05). Single filiform therapy and the therapy of filiform needle combined with fire needle were effective in treating frozen shoulder patients, and the effect of the filiform needle combined with fire needle was significantly better than single filiform needle. The effect of fire needle combined with filiform needle on the frozen shoulder in frozen stage was significantly better than single filiform needle. [ABSTRACT FROM AUTHOR]

OBJECTIVE: High mobility group protein N5 subtype (HMGN5) is overexpressed in bladder cancer tissue, while its specific mechanism in bladder cancer oncogenesis has not been fully elucidated. This study intends to investigate the impact of HMGN5 on clinical staging and prognosis of bladder cancer. PATIENTS AND METHODS: A total of 26 cases of patients with bladder transitional cell carcinoma (BTCC) received transurethral resection (TUR-BT) in our hospital between March 2015 and February 2016. Para-carcinoma tissue at 5 cm away from cancer tissue was selected as normal control. The expressions of HMGN5 mRNA and protein in different clinical stages were tested by Real-time PCR and Western blot. The relationship between HMGN5 expression and clinical stage along with prognosis was analyzed. RESULTS: HMGN5 mRNA was significantly elevated in BTCC tissue compared with that in para- carcinoma tissue (p < 0.05). HMGN5 mRNA level was gradually upregulated following BTCC upstage according to UICC-TNM stage and WHO stage. The level of HMGN5 protein showed similar changes with mRNA. Follow-up results demonstrated that patients with high HMGN5 level have more tendency of occurrence. CONCLUSIONS: HMGN5 protein level has an important influence on BTCC clinicopathological staging and prognosis. This investigation provides theoretical basis the future therapy of bladder cancer. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Breast cancer (BC) is one of the most common malignant tumors occurred in women. There is no sensitive and specific marker for early diagnosis, treatment and prognosis of breast cancer. It is suggested that miRNA may be a potential tumor marker for breast cancer. Mir-520g is considered to be associated with many tumors. This study aims to test the expression of mir-520g in peripheral blood of BC patients and healthy control. We also explored the relationship between mir-520g and several prognostic factors in breast cancer patients. PATIENTS AND METHODS: The peripheral blood of 86 cases with breast cancer (including 18 cases with stage 0, 24 cases of phase I, 20 cases of stage II, 24 cases of stage III) and 26 cases of healthy subjects were collected. The miR-520g level was measured by real-time quantitative PCR (RT qPCR) method. The correlation between plasma miR-520g level and the clinical stage, molecular subtype, receptors' expression and other factors related to the prognosis of the patients were examined. RESULTS: Plasma mir-520g expression levels were significantly higher in BC patients with lymph node metastatic and low differentiation degree grade (p = 0.033 and 0.016), and plasma miR-520g expression was significantly higher in breast cancer patients with mammary gland invasion (p < 0.01) and low expressed p53 (p = 0.0039). CONCLUSIONS: Highly expressed mir-520g is associated with lymph node metastasis and low differentiation of breast cancer, and also is associated with mammary gland invasion in breast cancer. This study suggests that mir-520g may be associated with some important prognostic factors in breast cancer patients, and may have a potential value for breast cancer marker. [ABSTRACT FROM AUTHOR]

Copyright of China Journal of Oral & Maxillofacial Surgery is the property of Shanghai Jiao Tong University, College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Colombiana de Obstetricia y Ginecologia is the property of Federacion Colombiana de Asociaciones de Obstetricia y Ginecologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract: Purpose: The transcription factor E2F3 plays an important role in controlling cell cycle progression and proliferation, and is overexpressed in various human cancers. The present study was undertaken to examine the expression of E2F3 and investigate its relevance in clinical and pathological features of pediatric Wilms’ tumors. Methods: Twenty-six Wilms’ tumor samples collected at the First Affiliated Hospital of Harbin Medical University underwent immunohistochemical staining for E2F3 protein expression by measuring the percentage of E2F3-positive cells and integrated optical density (IOD), and quantitative real-time polymerase chain reaction (qRT-PCR) for E2F3 mRNA expression. Results: The expression of E2F3 protein and mRNA was detectable in all the Wilms’ tumor samples with big variations (The average percentage of positive cells was 30.2%±23.5%, range 0.3%–75.6%; average IOD was 6.61×104 ±3.92×104, range 2.32×104–13.84×104; average relative mRNA unit was 0.54±0.38, range 0.03–1.31), but not in fetal kidney tissues. Wilms’ tumors with aggressive features, such as higher stage, unfavorable histology and higher risk level, expressed higher levels of E2F3 protein and mRNA. Conclusions: The preliminary data indicate that E2F3 is frequently expressed in pediatric Wilms’ tumors examined in the present study. E2F3 expression may be associated with Wilms’ tumors, particularly those that have more aggressive features. However, further studies are needed to validate these pilot observations and to clarify the functional and mechanistic significance of this association. [Copyright &y& Elsevier]

Rationale and Objectives: Both preoperative computed tomography (CT) staging and postoperative surgical Masaoka clinical staging are of great clinical importance for diagnosing thymomas. Our study aimed to investigate the relationships between these two staging systems. Materials and Methods: This was a retrospective review of 129 patients who had undergone thymoma surgery. Helical CT and 16-slice CT were performed preoperatively. Surgical findings were evaluated according to the Masaoka clinical staging system. Results: A significant association was shown between Masaoka clinical staging and CT staging, especially of features including tumor size (P = .004), tumor shape (P < .001), tumor density (P < .001), capsule completeness (P < .001), and involvement of surrounding tissues (P < .001). Based on the CT findings, there were 35.09% of Masaoka stage I patients who had a tumor size <5 cm as compared to 14.81% of stage IV patients. Only 8.77% of Masaoka stage I patients had a tumor size ≥10 cm as compared to 40.74% of stage IV patients. In stages III and IV, most tumors were irregularly shaped with an uneven density and incomplete capsule. Invasive tumors were more frequently found in stages III (81.48%) and IV (88.89%) than in stages I (0%) and II (38.89%). The incidence of myasthenia gravis was comparable in different stages. Consistency between CT and Masaoka clinical stages was higher in stage I (37.98%) than other stages (approximately 10%). Conclusion: This study documented a close relationship between preoperative CT thymoma staging and postoperative Masaoka clinical staging. Thus, preoperative CT findings can be beneficial for determining the proper management and prognosis of thymoma patients. [ABSTRACT FROM AUTHOR]

The article presents a study which explores the prognosis-related factors in patients with invasive cervical adenocarcinoma. It states the univariate analysis which showed poor prognosis in non-exophytic tumor, advanced clinical stage and mucinous adenocarcinoma. It also adds that tumor shape was an independent prognostic related factor besides pre-confirmed clinical stage, myometrial invasion and lymph node metastasis.

Introduction. Prostate cancer (PCa) is one of the most common cancers diagnosed in men. Its presentation has evolved substantially since the introduction of prostatespecific antigen (PSA) measurement in blood. The incidence of organ confined PCa has increased. Locally advanced cases are currently found rarely. However, there is still little knowledge concerning prostate cancer stage at diagnosis in many countries all over the world, including Poland. It is known that every other man diagnosed with PCa dies from this disease here. Therefore, this multicenter study was conducted prospectively to address PCa clinical stage defined at diagnosis, in Poland. The aim of the present study is to evaluate prospectively the clinical stage of newly diagnosed prostate cancer in selected institutions in Poland. Material and methods. Data of men who were subjected to prostate biopsy from 1st July 2007 to 30th July 2008 in selected institutions in Poland were analyzed. Results. Prostate biopsy was performed in 747 men aged between 34 and 93 years (mean age - 67.4). PCa was found in 52.7% of cases. Clinically organ-confined prostate cancer (cT =2) was diagnosed in 83.5% of them. Conclusions. Clinically organ-confined prostate cancer was diagnosed in most of the patients. However the results of the study indicate the presence of high incidence of locally advanced PCa at diagnosis. [ABSTRACT FROM AUTHOR]

The article presents the study conducted regarding the possible effects of cytokine production on the spread hydatid disease in human. The scheme will examine the production of the T helper cells(Th1/Th2) of cytokines in the diseases to determine the impact of the helper cells ratio in the evolution of the pathology. Hydatidosis is considered as a serious parasitic disease associated with the infection on the metacestode of the tapeworms Echinococcus granulosus. The result shows that Th1 cytokines are lined to the protective immunity while Th2 cytokines are the cause of diseases susceptibility which associated to clinical complications, chronicle age and secondary locations.

Copyright of Collegium Antropologicum is the property of Croatian Anthropological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper aims to assess diet and lifestyle by designing a healthy behavior index (HBI) related to the educational level and time of breast cancer (BC) diagnosis. 241 female breast cancer survivors treated at Centro Estatal de Cancerología (State Cancer Center) in Mexico were assessed based on dietary pattern, physical activity, smoking, alcohol consumption, body size and shape, sleep disorders with increasing scores that represent less healthy characteristics. The odds ratios (OR) and quartiles of the healthy behavior index and the time of diagnosis were estimated. The regression model was used to assess the association between HBI and the BC covariates. The healthy behavior index for the two first quartiles was that of p < 0.001. The graphic behavior of correspondence with the covariates (age, schooling and moderate physical activity) showed a different three-dimensional effect on healthy behaviors. According to diagnosis time ≤ three years, the following covariates were significant: socioeconomic status, (OR: 4.34 CI 95% 1.2-9.5), sleep disturbances (p = 020) and protective intake of fruits and vegetables (p = 0.001). In the multivariate analysis, survivors with a high level of education are significantly more likely to show a healthy behavior (OR: 0.3 95% CI 0.12 - 0.8); as well as the early clinical stages (OR: 0.4 95% CI 0.2–0.9). In breast cancer survivors, both the high level of education and early clinical stages were important healthy behavior modifiers. Since diets are potentially modifiable, the findings may have further implications to promote a careful dietary pattern to prevent breast cancer. These variables should be assessed as a strategy in cancer survivor preventive programs. • The level of education played a key role when adopting a healthy behavior. • Sleep disorders were also more evident in the first years after the diagnosis. • Women with early clinical stages were the healthiest. • The survivors diagnosed before three years have an adequate quality of diet. [ABSTRACT FROM AUTHOR]