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Despite the frequent co-administration of antidepressants and benzodiazepines, the association between such concomitant use during pregnancy and the risk of congenital malformations remains inadequately explored. This study aims to examine the association between concomitant use of antidepressants and benzodiazepines during the first trimester and organ-specific congenital malformations.

Benzodiazepines and Z-hypnotics are commonly prescribed for anxiety and insomnia during pregnancy, but the evidence regarding potential adverse neonatal outcomes is insufficient because of poor control for confounding factors in previous studies. We therefore aimed to evaluate the association between the use of benzodiazepines or Z-hypnotics during early pregnancy and adverse neonatal outcomes (stillbirth, preterm birth, and small for gestational age).

In‐cell ambient color sensors are best suited for phones with full‐screen LCDs. However, it faces its technical challenges, how to accurately estimate illuminance and color temperature based on non‐colorimetric RGBW signals. To this end, an optimized angular response optical design is proposed, and the color accuracy is improved by light source identification and weighted polynomial regression.

We present mosaic 46,XY,der(15)t(6;15)(q25.1;p12)/46,XY at amniocentesis in a pregnancy associated with a favorable fetal outcome and postnatal decrease of the aneuploid cell line with the unbalanced translocation.

We present perinatal molecular cytogenetic analysis of low-level mosaicism for trisomy 21 in a pregnancy with maternal uniparental disomy (UPD) of chromosome 21 in the fetus.

We present detection of a familial 1q21.1 microdeletion and concomitant CHD1Lmutation in a fetus with oligohydramnios and bilateral renal dysplasia on prenatal ultrasound.

Identify risk factors for development of preeclampsia refractory to aspirin prophylaxis in women at high-risk of preeclampsia.

We present prenatal diagnosis of mosaic trisomy 21 at amniocentesis associated with unbalanced Robertsonian translocation in the fetus and a favorable fetal outcome.

We present perinatal imaging findings of a fetus with Pfeiffer syndrome and a heterozygous c.1019A>G, p.Tyr340Cys (Y340C) mutation in FGFR2presenting a cloverleaf skull, craniosynostosis and short limbs on prenatal ultrasound mimicking thanatophoric dysplasia type II (TD2).

We present prenatal diagnosis of low-level mosaicism for tetrasomy 18p at amniocentesis in a pregnancy with a favorable outcome.

We present mosaic trisomy 16 at amniocentesis in a pregnancy associated with positive non-invasive prenatal testing (NIPT) for trisomy 16, placental trisomy 16, intrauterine growth restriction (IUGR), intrauterine fetal death (IUFD), cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes and uncultured amniocytes, and prenatal progressive decrease of the aneuploid cell line.

We present molecular cytogenetic characterization of del(X) (p22.33)mat and de novodup(4) (q34.3q35.2) in a male fetus with multiple anomalies of facial dysmorphism, ventriculomegaly, congenital heart defects, short long bones and clinodactyly.

We present low-level mosaic trisomy 17 at amniocentesis in a pregnancy associated with a favorable fetal outcome and cytogenetic discrepancy between cultured and uncultured amniocytes.

The aim of this research was to present prenatal diagnosis of Langer-Giedion syndrome (LGS/TRPS type II) and Cornelia de Lange syndrome-4 (CDLS4).

In developing a daylighting system, the overall system efficiency is crucial. In the daylighting system, whether the light propagates parallel strongly affects the efficiency. In this paper, we simulate a multicurvature lens to collimate rays propagated from different angles. We describe a method based on a freeform microlens array, which increases transmission efficiency. Results show that with the freeform microlens array collimator, the light propagates provide at least 50.26% parallel and the efficiency increases by 24.76%, enhancing the core values of the daylighting system in building illumination.

The daylighting system is designed to guide sunlight into buildings for illumination. It has the best illumination performance when sunlight vertically impinges on the collector of the daylighting system, while it has low performance when sunlight impinges obliquely. To overcome the problem, this paper investigates the design of a heliostat that reflects sunlight vertically onto a daylighting system. This study proposes a 3×3 mirror matrix heliostat, which is different from the traditional heliostat with one single mirror. With the heliostat, the system efficiency increases as high as 3.32 times.

We present a case of VACTERL association with hydrocephalus (VACTERL-H) in a fetus conceived by in vitrofertilization (IVF) and embryo transfer (ET) and review the literature.

To present prenatal diagnosis of mosaic trisomy 2.

To present a prenatal diagnosis of familial tuberous sclerosis complex (TSC).

This study is aimed at prenatal diagnosis of a distal 3p deletion associated with fetoplacental chromosomal discrepancy and confined placental mosaicism, and providing evidence for the limitation of array comparative genomic hybridization (aCGH) on placental tissues for molecular cytogenetic characterization of prenatally detected aneuploidy.

To present prenatal diagnosis and molecular cytogenetic characterization of trisomy 18 in a monozygotic twin pregnancy, with one structurally abnormal living fetus and one intrauterine fetal demise.

To demonstrate perinatal imaging findings and to investigate the mutation in the NEK1gene in a fetus with type III short rib-polydactyly syndrome (SRPS) (Verma-Naumoff).

This study was conducted to document the perinatal risk factors associated with early-onset neonatal Escherichia colisepsis and adverse neonatal outcomes.

To present prenatal diagnosis and molecular cytogenetic characterization of Wolf-Hirschhorn syndrome (WHS) associated with microduplications at 8p and 10p in a fetus with an apparently pure 4p deletion.

In recent trend, LED begins to replace traditional light sources since it has many advantages, such as long lifespan, low power consumption, environmentally mercury-free, broad color gamut, and so on. According to the zonal lumen density requirement of ENERGY STAR, we design a triangular-prism structure for LED light tube. The optical structure of the current LED light tubes consists of the array of LED and the semi-cylindrical diffuser in which the intensity distribution of LED is based on Lambertian and the characteristics of diffuser are BTDF: 63%, transmission: 27%, and absorption: 10%. We design the triangular-prism structure at the both sides of the semi-circular diffuser to control the wide-angle light and use the Taguchi method to optimize the parameters of the structure that will control the 10.41% of total flux to light the area between 90 degree and 135 degree and to avoid the total internal reflection. According to the optical simulation results, the 89.59% of total flux is within 90 degree and the 10.41% of total flux is between 90 degree and 135 degree that match with the Solid-State Lighting (SSL) Criteria V. 1.1 of ENERGY STAR.

Natural light is an inexhaustible and environmentally friendly energy. The solar energy exposed to the earth everyday is about three thousand times to the global energy consumption. Therefore, it would be a considerably large energy saving if we collect and guide the sunlight for lighting. Currently, there are two types of solar concentrators for collecting sunlight purpose, namely, active and static. The former is more efficient, but needs costly active sun-tracking system for supplement; the latter is cheaper, but is limited for certain time slots. In static systems, a hemispherical concentrator can gather the sunlight with longer time, but the collected flux is not stable and the energy density of optical fiber is lower than the illuminance of sunlight. We, in this paper, propose a hemispherical static concentrator that consists of double aspheric compensated lens array. The double layers of lenses are designed with large tolerance for continued collecting sunlight and the apertures of lenses are larger than optical fiber for increasing the energy density. According to the simulation results, we get uniform distribution of collected flux from 10 a.m. to 4 p.m. that is less than 10% change. Moreover, the energy density of optical fiber is about 50 Lm/cm2in summer when the illuminance of sunlight is about 120,000 Lux.

To present prenatal diagnosis of chromosome 1p32-p31 deletion syndrome with NFIAhaploinsufficiency, ventriculomegaly, corpus callosum hypogenesis, abnormal external genitalia, and intrauterine growth restriction and to review the literature.

To report five cases of major congenital malformations associated with common aneuploidies detected by rapid aneuploidy diagnosis.

In recent years, green energy has undergone a lot of development and has been the subject of many applications. Many research studies have focused on illumination with sunlight as a means of saving energy and creating healthy lighting. Natural light illumination systems have collecting, transmitting, and lighting elements. Today, most daylight collectors use dynamic concentrators; these include Sun tracking systems. However, this design is too expensive to be cost effective. To create a low-cost collector that can be easily installed on a large building, we have designed a static concentrator, which is prismatic and cascadable, to collect sunlight for indoor illumination. The transmission component uses a large number of optical fibers. Because optical fibers are expensive, this means that most of the cost for the system will be related to transmission. In this paper, we also use a prismatic structure to design an optical coupler for coupling n to 1. With the n-to-1 coupler, the number of optical fibers necessary can be greatly reduced. Although this new natural light illumination system can effectively guide collected sunlight and send it to the basement or to other indoor places for healthy lighting, previously there has been no way to manage the collected sunlight when lighting was not desired. To solve this problem, we have designed an optical switch and a beam splitter to control and separate the transmitted light. When replacing traditional sources, the lighting should have similar characteristics, such as intensity distribution and geometric parameters, to those of traditional artificial sources. We have designed, simulated, and optimized an illumination lightpipe with a dot pattern to redistribute the collected sunlight from the natural light illumination system such that it equals the qualities of a traditional lighting system. We also provide an active lighting module that provides lighting from the natural light illumination system or LED auxiliary sources, depending on circumstances. The system is controlled by a light detector. We used optical simulation tools to design and simulate the efficiency of the active module. Finally, we used the natural light illumination system to provide natural illumination for a traffic tunnel. This system will provide a great number of benefits for the people who use it.

To evaluate the demographics, clinical presentations, laboratory findings, and maternal and fetal outcomes in patients with acute fatty liver of pregnancy.

We present prenatal diagnosis of a 15q11.2-q14 deletion of paternal origin associated with increased nuchal translucency (NT), mosaicism for de novomultiple unbalanced translocations involving 15q11-q14, 5qter, 15qter, 17pter and 3qter, and Prader–Willi syndrome (PWS).

LED has many advantages that will replace traditional light sources. In this article, we design a convergence lens and use a LED light source with ± 30° half-power angle. The lens can convergence light source and make it become parallel light. The goal to achieve high directivity can be applied to wireless sensors. According to the simulation results, compared to the LED with dome lens that has ± 0.6° half-power angle, the LED use our design's lens has ± 0.34° half-power angle. In the same transmission distance, the LED with our design's lens has more than 200 times received energy.