63 results on '"Chen, Xingxing"'
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2. Achieving High-Performance Polymer-Wrapper-Free Aligned Carbon Nanotube Field-Effect Transistors Through Degradable Polymer Wrapping and Efficient Removal Techniques
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Bai, Lan, Lin, Yanxia, Chen, Xingxing, Yin, Huimin, Jin, Chuanhong, Wang, Youzhen, Zhang, Zhiyong, Peng, Lian-Mao, Liang, Xuelei, and Cao, Yu
- Abstract
Semiconducting carbon nanotubes (s-CNTs) have emerged as a promising alternative to traditional silicon for ultrascaled field-effect transistors (FETs), owing to their exceptional properties. Aligned s-CNTs (A-CNTs) are particularly favored for practical applications due to their ability to provide higher driving current and lower contact resistance compared with individual s-CNTs or random networks. Achieving high-semiconducting-purity A-CNTs typically involves conjugated polymer wrapping for selective separation of s-CNTs, followed by self-assembly techniques. However, the presence of the polymer wrapper on A-CNTs can adversely impact electrical contact, gating efficiency, carrier transport, and device-to-device variations, necessitating its complete removal. While various methods have been explored for polymer removal, accurately characterizing the extent of removal remains a challenge. Traditional techniques such as absorption spectroscopy and X-ray photoelectron spectroscopy (XPS) may not accurately depict the remaining polymer content on A-CNTs due to their inherent detection limits. Consequently, the performance of FETs based on pure polymer-wrapper-free A-CNTs is unclear. In this study, we present an approach for preparing high-semiconducting-purity and polymer-wrapper-free A-CNTs using poly[(9,9-dioctylfluorenyl-2,7-dinitrilomethine)-(9,9-dioctylfluorenyl-2,7-dimethine)] (PFO-N-PFO), a degradable polymer, in conjunction with a modified dimension-limited self-alignment process (m-DLSA). Comprehensive transmission electron microscopy (TEM) characterizations, complemented by absorption and XPS characterizations, provide robust evidence of the successful near-complete removal of the polymer wrapper via a cleaning procedure involving acidic degradation, hot solvent rinsing, and vacuum annealing. Furthermore, top-gated FETs based on these high-semiconducting-purity and polymer-wrapper-free A-CNTs exhibit good performance metrics, including an on-current (Ion) of 2.2 mA/μm, peak transconductance (gm) of 1.1 mS/μm, low contact resistance (Rc) of 191 Ω·μm, and negligible hysteresis, representing a significant advancement in the CNT-based FET technology.
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- 2024
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3. Decentralized Energy Management of Renewable Hydrogen Production Systems Without Communication Networks
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Song, Qingchao, Chen, Xingxing, Liu, Junwei, Chen, Jiawei, and Loo, Ka-Hong
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With the increasing penetration of renewable generation, producing renewable hydrogen by water electrolysis has become a promising development. For hydrogen production systems integrated with renewable energy sources (RESs), alkaline electrolyzers (AELs), and energy storage devices, its energy management system (EMS) not only controls the RESs’ operating points to capture more renewable energy but also regulates the AELs and energy storage devices’ operating power to achieve dc bus voltage regulation, dynamic power sharing, power regulation of AELs, state-of-charge regulation of energy storage devices, etc. In this article, a decentralized EMS is proposed to achieve the above objectives. The proposed EMS can indirectly improve the system's efficiency and service life by ensuring that the AEL's operating power is always above the minimum recommended operating power and it only absorbs the low-frequency part of renewable power fluctuations. Besides, the proposed EMS can reduce system costs and enhance system reliability by eliminating communication networks. Furthermore, the operational principle of the proposed EMS and the system design and analysis are elaborated. The proposed EMS's effectiveness is verified by hardware-in-the-loop real-time simulations.
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- 2024
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4. Brain Radiotherapy With Pyrotinib and Capecitabine in Patients With ERBB2-Positive Advanced Breast Cancer and Brain Metastases: A Nonrandomized Phase 2 Trial
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Yang, Zhaozhi, Meng, Jin, Mei, Xin, Mo, Miao, Xiao, Qin, Han, Xu, Zhang, Li, Shi, Wei, Chen, Xingxing, Ma, Jinli, Palmer, Joshua, Shao, Zhimin, Zhang, Zhen, Yu, Xiaoli, and Guo, Xiaomao
- Abstract
IMPORTANCE: The potential benefit of combining intracranial effective systemic therapy with radiotherapy for patients with breast cancer with brain metastases remains unclear. OBJECTIVE: To assess the activity and safety of combining radiotherapy with pyrotinib and capecitabine in patients with ERBB2-positive breast cancer and brain metastases. DESIGN, SETTING, AND PARTICIPANTS: This was a single-arm, single-center, phase 2 nonrandomized clinical trial with a safety run-in phase. Between January 2020 and August 2022, patients with ERBB2-positive breast cancer and brain metastases were enrolled. The data cutoff date was February 1, 2023. INTERVENTIONS: Patients received either fractionated stereotactic radiotherapy or whole-brain radiotherapy. Treatment with pyrotinib (400 mg, once daily) and capecitabine (1000 mg/m2, twice daily, on days 1-14 of each 21-day cycle) was initiated from the first day of radiotherapy to the seventh day after the completion of radiotherapy and continued until disease progression or unacceptable toxic effects. MAIN OUTCOMES AND MEASURES: The primary end point was 1-year central nervous system (CNS) progression-free survival (PFS) rate. Secondary end points included CNS objective response rate (ORR), PFS, overall survival (OS), safety, and changes in neurocognitive function. RESULTS: A total of 40 female patients (median age, 50.5 years [IQR, 46-59 years]) were enrolled and received treatment, including 3 patients in safety run-in phase. With a median follow-up of 17.3 months (IQR, 10.3-26.9), the 1-year CNS PFS rate was 74.9% (95% CI, 61.9%-90.7%), and the median CNS PFS was 18.0 months (95% CI, 15.5 to not reached). The 1-year PFS rate was 66.9% (95% CI, 53.1%-84.2%), and the median PFS was 17.6 months (95% CI, 12.8-34.1). The CNS objective response rate was 85% (34 of 40). Median overall survival was not reached. The most common grade 3 or 4 treatment-related adverse event was diarrhea (7.5%). Asymptomatic radiation necrosis was identified in 4 of 67 lesions (6.0%) treated with fractionated stereotactic radiotherapy. Most patients maintained neurocognitive function, as evaluated by the Mini-Mental State Examination at different points. CONCLUSIONS AND RELEVANCE: The results of this trial suggest that radiotherapy combined with pyrotinib and capecitabine is associated with long intracranial survival benefit in patients with ERBB2-positive advanced breast cancer and brain metastases with an acceptable safety profile. This combination deserves further validation. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04582968
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- 2024
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5. Population mobility and employee social responsibility: evidence from hukou reform in China
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Li, Lidan, Song, Xianzhong, Yang, Yupeng, and Chen, Xingxing
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ABSTRACTPopulation mobility may have a profound impact on the labor market, affecting firms’ employment decisions. We consider hukou reform in China as a quasi-natural experiment in identifying the effects of population mobility on employee-related corporate social responsibility (employee social responsibility, or ESR). The empirical results show that hukou reform prompts firms to invest more in ESR activities, particularly in ESR activities with weak externalities and in regions with a smaller labor market size. Cross-sectional tests suggest that the effects of hukou reform on firms’ ESR investment are stronger for more financially constrained firms and those in high-tech industries, and in more competitive regions. The findings have important practical implications for employment strategies that firms should adopt when the labor market becomes more competitive.
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- 2023
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6. An Efficient Code-Embedding-Based Vulnerability Detection Model for Ethereum Smart Contracts
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Xu, Zhigang, Chen, Xingxing, Dong, Xinhua, Han, Hongmu, Yan, Zhongzhen, Ye, Kangze, Li, Chaojun, Zheng, Zhiqiang, Wang, Haitao, and Zhang, Jiaxi
- Abstract
Efficient and convenient vulnerability detection for smart contracts is a key issue in the field of smart contracts. The earlier vulnerability detection for smart contracts mainly relies on static symbol analysis, which has high accuracy but low efficiency and is prone to path explosion. In this paper, the authors propose a static method for vulnerability detection based on deep learning. It first disassembles Ethereum smart contracts into opcode sequences and then converts the vulnerability detection problem into a natural language text classification problem. The word vector method is employed to map each opcode to a uniform vector space, and the opcode sequence matrix is trained by the TextCNN method to detect vulnerabilities. Furthermore, a code obfuscation method is given to enhance and balance the dataset, while three different opcode sequence generation methods are proposed to construct features. The experimental results verify that the average prediction accuracy of each smart contract exceeds 96%, and the average detection time is less than 0.1 s.
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- 2023
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7. Do greener funds perform better? An analysis of open-end equity funds in China
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Chen, Xingxing, Weber, Olaf, Song, Xianzhong, and Li, Lidan
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ABSTRACTThis study analyses how equity funds react to institutional pressure related to green finance. Based on the analysis of 378 open-end equity funds in China from 2010 to 2019, we examined the environmental performance of fund holdings to measure their level of green investment. In our analyses, we distinguished between funds with positive and negative screening strategies. Our results indicate that the funds’ green investments are gradually increasing. Furthermore, we found that green investment strategies help to increase the funds’ excess return. The positive connection to financial returns, however, is only valid for funds with negative screening strategies. Finally, we found that fund investors react negatively to funds using positive screening to identify green investments. The study contributes to theoretical and practical knowledge about factors influencing equity funds’ green and financial performance.
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- 2023
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8. Effective Absorption Mechanism of SO2 and NO2 in the Flue Gas by Ammonium-Bromide-Based Deep Eutectic Solvents.
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Zhou, Tengteng, Zhao, Yongqi, Xiao, Xinxin, Liu, Yixuan, Bai, Hongcun, Chen, Xingxing, Dou, Jinxiao, and Yu, Jianglong
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- 2022
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9. Modulation of Photogenerated Carrier Transport by Integration of Sb2O3 with Fe2O3 for Improved Photoelectrochemical Water Oxidation.
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Chen, Fukun, Pan, Haoran, Lu, Zhenjie, Huang, Xinning, Sun, Zhenyu, and Chen, Xingxing
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- 2022
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10. An MMC DC-Link Voltage Control Method Without Actual Voltage Measurement
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Song, Shuguang, Liu, Jinjun, and Chen, Xingxing
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DC-link voltage control is of great importance for modular multilevel converter (MMC)-based high-voltage direct-current (HVDC) systems. Existing methods need to measure the actual dc-link voltage, which are referred to as direct control methods in this article and require a reliable dc voltage measuring device. The measurement system is complicated. Also, once malfunction occurs, dc-link voltage control may fail. This article aims to develop a dc-link voltage control method without actual voltage measurement. The idea is based on the coupling effect between dc-link voltage and submodule (SM) capacitor voltage. Based on the analysis, an indirect dc-link voltage control method is proposed. In this method, the existing dc-link voltage control loop is first replaced by the total capacitor voltage regulation control loop. Then, a compensation signal is introduced to the switching functions to mitigate undesired voltage deviation. Two approaches are proposed to generate a proper compensation signal. The proposed method can be integrated into the existing MMC control system. Also, in measurement failure cases, it can come into service and continue maintaining MMC dc-link voltage, improving system reliability. Both simulation and experimental results confirm the validity and effectiveness of the proposed method.
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- 2022
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11. Solar interfacial evaporation for efficient treatment of sewage containing volatile organic compounds and toxic heavy metal ions: A sequential process of adsorption, coagulation, and evaporation.
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Chen, Xingxing, Liang, Xuechen, Zhou, Zhou, Song, Lulu, Wang, Yating, Tan, Enpei, Liu, Yujun, and Tan, Ying
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VOLATILE organic compounds ,METAL ions ,HEAVY metals ,POLYMER solutions ,COAGULATION - Abstract
Solar interfacial evaporation (SIE) is an eco-friendly and sustainable technology for addressing water pollution and freshwater scarcity. However, treating wastewater containing volatile organic compounds and heavy metal ions with a single SIE method is inefficient. The combination of adsorption, coagulation, and evaporation process provides an alternative solution for treating this type of wastewater. In this study, activated carbon powder (C) is introduced as an adsorbent and an integral part of photothermal conversion material, which is coagulated with polyvinyl alcohol (PVA) and polyethylene glycol (PEG) through a mold press process to fabricate PVA/C/PEG composite hydrogels. The volatile organic compounds and heavy metal ions in the wastewater are adsorbed by the activated carbon powder and the wastewater is then further purified into freshwater through SIE. This stepwise "adsorption first, then coagulation and evaporation" method can not only rapidly remove pollutants from the raw water, but also provides a much higher removal efficiency than the adsorption-evaporation synergetic process. This work demonstrates a successful attempt to utilize the SIE method for treating wastewater containing volatile organic compounds and heavy metal ions. [Display omitted] • The treatment process is focused on sewage containing VOCs and heavy metal ions. • A three-step treatment method of adsorption, coagulation, evaporation is designed. • Activated carbon has high adsorption efficiency for some VOCs and heavy metals. • Polymer solution composite method endows PVA/C/PEG with a high water supply rate. • PVA/C/PEG reaches 1.813 kg m−2 h−1 water evaporation rate under 1 sun for 7 hours. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Efficacy and safety of high-dose esomeprazole–amoxicillin dual therapy for Helicobacter pylorirescue treatment: a multicenter, prospective, randomized, controlled trial
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Bi, Hanxin, Chen, Xingxing, Chen, Yuxin, Zhao, Xin, Wang, Shasha, Wang, Jiehong, Lyu, Ting, Han, Shuang, Lin, Tao, Li, Mingquan, Yuan, Donghong, Liu, Junye, Shi, Yongquan, and Ji, Yuanyuan
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- 2022
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13. Symptoms Related to Brachial Plexus Neuropathy After Supraclavicular Irradiation and Boost in Breast Cancer.
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Jin, Kairui, Luo, Jurui, Wang, Xuanyi, Yang, Zhaozhi, Zhang, Li, Mei, Xin, Ma, Jinli, Chen, Xingxing, Zhang, Xiaomeng, Zhou, Zhirui, Wang, Xiaofang, Shao, Zhimin, Zhang, Zhen, Guo, Xiaomao, and Yu, Xiaoli
- Abstract
To evaluate the incidence of symptoms related to brachial plexus neuropathy (BPN) and the dose distribution to the brachial plexus (BP) in patients with breast cancertreated with supraclavicular (SCV) irradiation and boost. In this study, 117 patients with initial ipsilateral supraclavicular lymph node (SLN) metastasis and 39 with recurrent SLN metastasis between 2008 and 2018 in our cancer center were retrospectively analyzed. All patients were treated with 50 Gy of SCV irradiation in 25 fractions and a boost (median dose, 10 Gy; range, 10-16 Gy) to involved nodes in the SCV area. Symptoms related to BPN (including ipsilateral arm numbness, pain, and weakness) were recorded and graded according to the Common Terminology Criteria for Adverse Events, version 5.0. The BP was delineated on simulation computed tomography, and the dose distributions to the BP were evaluated. Meanwhile, 297 patients treated with SCV irradiation without boost during the same period were identified as a control group to compare the incidences of BPN-related symptoms and dosimetric data with patients who received an SCV boost. The 5-year overall survival rate was 80.3% for patients with initial SLN metastasis and 51.0% for patients with recurrent SLN metastasis. For patients who received an SCV boost, incidence rates of ipsilateral arm numbness, pain, and weakness were 23.9%, 18.3%, and 34.3%, respectively. Four patients (5.6%) developed grade 2 numbness and 3 (4.3%) developed grade 2 arm weakness. In the control group, incidence rates of arm numbness, pain, and weakness were 31.6%, 21.9%, and 36.0%, respectively. The incidence of BPN-related symptoms was not significantly different between the 2 groups. Symptoms of grade 3 were not observed in either cohort. The mean doses to the BP in patients who received boost and who did not were 56.8 and 46.8 Gy, respectively (P <.001). The maximum doses to the BP in patients who received boost and who did not were 64.5 and 53.5 Gy, respectively (P <.001). The BP volumes receiving at least 50 Gy, 60 Gy, 61 Gy, and 62 Gy were also significantly higher in the boosted group compared with the control group (P <.001). This study found that an SCV boost of 10 Gy did not increase the incidence of BPN-related symptoms and that the toxicity to the BP was acceptable. Comprehensive treatment including SCV irradiation and boost led to satisfactory survival outcomes in patients with breast cancer who had SLN metastasis. [ABSTRACT FROM AUTHOR]
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- 2022
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14. Redox-Active Polymers Designed for the Circular Economy of Energy Storage Devices.
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Tan, Siew Ting Melissa, Quill, Tyler J., Moser, Maximilian, LeCroy, Garrett, Chen, Xingxing, Wu, Yilei, Takacs, Christopher J., Salleo, Alberto, and Giovannitti, Alexander
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- 2021
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15. Prevalence of suicidal ideation among stroke survivors: A systematic review and meta-analysis.
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Chen, Xingxing, Zhang, Hua, Xiao, Gui, and Lv, Chuanzhu
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ONLINE information services ,META-analysis ,MEDICAL databases ,INFORMATION storage & retrieval systems ,SYSTEMATIC reviews ,SUICIDAL ideation ,STROKE patients ,DISEASE prevalence ,DESCRIPTIVE statistics ,RESEARCH funding ,MEDLINE ,DATA analysis software - Abstract
Background: The prevalence of suicidal ideation (SI) among stroke survivors has been the subject of several studies, but systematic review data regarding the prevalence of SI among stroke patients are still scarce. Objectives: To estimate the pooled prevalence of SI among stroke survivors. Methods: A comprehensive search strategy was established across the following electronic databases; Web of Science, PubMed, the Cochrane Library, Chinese Wanfang database and Chinese National Knowledge Infrastructure (CNKI). The 95% confidence interval (CI) given in each identified study was used to assess the outcomes. Cochran's Q test and I
2 statistic were used to evaluate heterogeneity. The quality of the final evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. We calculated the pooled prevalence of SI among stroke survivors before subgroup analysis and meta-regression was used to find the partial source of heterogeneity. Results: Twenty-one studies with a total of 17,189 participants were included in this study and the pooled prevalence of SI among stroke survivors was 12.25% (95%CI: 9.91–15.07%). Substantial heterogeneity was detected in the estimation of prevalence. The evidence was graded as very low for the overall outcome and the single item subgroup, while it was graded as low for the stable scale subgroup. Conclusions: This meta-analysis suggests a high prevalence of SI among stroke survivors. Routine screening of SI after stroke is needed to plan interventions aimed at reducing suicide risk. [ABSTRACT FROM AUTHOR]- Published
- 2021
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16. An anonymous authentication and secure data transmission scheme for the Internet of Things based on blockchain
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Chen, Xingxing, Cheng, Qingfeng, Yang, Weidong, and Luo, Xiangyang
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With the widespread use of network infrastructures such as 5G and low-power wide-area networks, a large number of the Internet of Things (IoT) device nodes are connected to the network, generating massive amounts of data. Therefore, it is a great challenge to achieve anonymous authentication of IoT nodes and secure data transmission. At present, blockchain technology is widely used in authentication and s data storage due to its decentralization and immutability. Recently, Fan et al. proposed a secure and efficient blockchain-based IoT authentication and data sharing scheme. We studied it as one of the state-of-the-art protocols and found that this scheme does not consider the resistance to ephemeral secret compromise attacks and the anonymity of IoT nodes. To overcome these security flaws, this paper proposes an enhanced authentication and data transmission scheme, which is verified by formal security proofs and informal security analysis. Furthermore, Scyther is applied to prove the security of the proposed scheme. Moreover, it is demonstrated that the proposed scheme achieves better performance in terms of communication and computational cost compared to other related schemes.
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- 2024
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17. Solar interfacial evaporation for efficient treatment of sewage containing volatile organic compounds and toxic heavy metal ions: A sequential process of adsorption, coagulation, and evaporation
- Author
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Chen, Xingxing, Liang, Xuechen, Zhou, Zhou, Song, Lulu, Wang, Yating, Tan, Enpei, Liu, Yujun, and Tan, Ying
- Abstract
Solar interfacial evaporation (SIE) is an eco-friendly and sustainable technology for addressing water pollution and freshwater scarcity. However, treating wastewater containing volatile organic compounds and heavy metal ions with a single SIE method is inefficient. The combination of adsorption, coagulation, and evaporation process provides an alternative solution for treating this type of wastewater. In this study, activated carbon powder (C) is introduced as an adsorbent and an integral part of photothermal conversion material, which is coagulated with polyvinyl alcohol (PVA) and polyethylene glycol (PEG) through a mold press process to fabricate PVA/C/PEG composite hydrogels. The volatile organic compounds and heavy metal ions in the wastewater are adsorbed by the activated carbon powder and the wastewater is then further purified into freshwater through SIE. This stepwise “adsorption first, then coagulation and evaporation” method can not only rapidly remove pollutants from the raw water, but also provides a much higher removal efficiency than the adsorption-evaporation synergetic process. This work demonstrates a successful attempt to utilize the SIE method for treating wastewater containing volatile organic compounds and heavy metal ions.
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- 2024
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18. Synthetic Nuances to Maximize n-Type Organic Electrochemical Transistor and Thermoelectric Performance in Fused Lactam Polymers
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Marks, Adam, Chen, Xingxing, Wu, Ruiheng, Rashid, Reem B., Jin, Wenlong, Paulsen, Bryan D., Moser, Maximilian, Ji, Xudong, Griggs, Sophie, Meli, Dilara, Wu, Xiaocui, Bristow, Helen, Strzalka, Joseph, Gasparini, Nicola, Costantini, Giovanni, Fabiano, Simone, Rivnay, Jonathan, and McCulloch, Iain
- Abstract
A series of fully fused n-type mixed conduction lactam polymers p(g7NCnN), systematically increasing the alkyl side chain content, are synthesized via an inexpensive, nontoxic, precious-metal-free aldol polycondensation. Employing these polymers as channel materials in organic electrochemical transistors (OECTs) affords state-of-the-art n-type performance with p(g7NC10N)recording an OECT electron mobility of 1.20 × 10–2cm2V–1s–1and a μC* figure of merit of 1.83 F cm–1V–1s–1. In parallel to high OECT performance, upon solution doping with (4-(1,3-dimethyl-2,3-dihydro-1H-benzoimidazol-2-yl)phenyl)dimethylamine (N-DMBI), the highest thermoelectric performance is observed for p(g7NC4N), with a maximum electrical conductivity of 7.67 S cm–1and a power factor of 10.4 μW m–1K–2. These results are among the highest reported for n-type polymers. Importantly, while this series of fused polylactam organic mixed ionic–electronic conductors (OMIECs) highlights that synthetic molecular design strategies to bolster OECT performance can be translated to also achieve high organic thermoelectric (OTE) performance, a nuanced synthetic approach must be used to optimize performance. Herein, we outline the performance metrics and provide new insights into the molecular design guidelines for the next generation of high-performance n-type materials for mixed conduction applications, presenting for the first time the results of a single polymer series within both OECT and OTE applications.
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- 2022
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19. Measurement and modeling of magnetic declination error associated with horizontal drift
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Wang, Yulin, Chen, Siting, Qian, Junli, Chen, Xingxing, Wang, Minggui, Ge, Jian, Zhou, Chao, and Zhang, Jiantao
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- 2022
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20. PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis
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Yang, Weili, Guo, Xiangyu, Tu, Zhuchi, Chen, Xiusheng, Han, Rui, Liu, Yanting, Yan, Sen, Wang, Qi, Wang, Zhifu, Zhao, Xianxian, Zhang, Yunpeng, Xiong, Xin, Yang, Huiming, Yin, Peng, Wan, Huida, Chen, Xingxing, Guo, Jifeng, Yan, Xiao-Xin, Liao, Lujian, Li, Shihua, and Li, Xiao-Jiang
- Abstract
In vitrostudies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson’s disease (PD). However, difficulty in detecting endogenous PINK1 protein in rodent brains and cell lines has prevented the rigorous investigation of the in vivorole of PINK1. Here we report that PINK1 kinase form is selectively expressed in the human and monkey brains. CRISPR/Cas9-mediated deficiency of PINK1 causes similar neurodegeneration in the brains of fetal and adult monkeys as well as cultured monkey neurons without affecting mitochondrial protein expression and morphology. Importantly, PINK1mutations in the primate brain and human cells reduce protein phosphorylation that is important for neuronal function and survival. Our findings suggest that PINK1 kinase activity rather than its mitochondrial function is essential for the neuronal survival in the primate brains and that its kinase dysfunction could be involved in the pathogenesis of PD.
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- 2022
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21. On-Chip Multicolor Photoacoustic Imaging Flow Cytometry.
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Jin, Tian, Zhang, Chen, Liu, Fei, Chen, Xingxing, Liang, Guangru, Ren, Fei, Liang, Suzi, Song, Chaolong, Shi, Jianbing, Qiu, Weibao, Jiang, Xingyu, Li, Kai, and Xi, Lei
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- 2021
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22. Reversible Electrochemical Charging of n-Type Conjugated Polymer Electrodes in Aqueous Electrolytes
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Szumska, Anna A., Maria, Iuliana P., Flagg, Lucas Q., Savva, Achilleas, Surgailis, Jokubas, Paulsen, Bryan D., Moia, Davide, Chen, Xingxing, Griggs, Sophie, Mefford, J. Tyler, Rashid, Reem B., Marks, Adam, Inal, Sahika, Ginger, David S., Giovannitti, Alexander, and Nelson, Jenny
- Abstract
Conjugated polymers achieve redox activity in electrochemical devices by combining redox-active, electronically conducting backbones with ion-transporting side chains that can be tuned for different electrolytes. In aqueous electrolytes, redox activity can be accomplished by attaching hydrophilic side chains to the polymer backbone, which enables ionic transport and allows volumetric charging of polymer electrodes. While this approach has been beneficial for achieving fast electrochemical charging in aqueous solutions, little is known about the relationship between water uptake by the polymers during electrochemical charging and the stability and redox potentials of the electrodes, particularly for electron-transporting conjugated polymers. We find that excessive water uptake during the electrochemical charging of polymer electrodes harms the reversibility of electrochemical processes and results in irreversible swelling of the polymer. We show that small changes of the side chain composition can significantly increase the reversibility of the redox behavior of the materials in aqueous electrolytes, improving the capacity of the polymer by more than one order of magnitude. Finally, we show that tuning the local environment of the redox-active polymer by attaching hydrophilic side chains can help to reach high fractions of the theoretical capacity for single-phase electrodes in aqueous electrolytes. Our work shows the importance of chemical design strategies for achieving high electrochemical stability for conjugated polymers in aqueous electrolytes.
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- 2021
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23. Introduction of a Stable Radical in Polymer Capacitor Enables High Energy Storage and Pulse Discharge Efficiency.
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Ma, Li, Zhang, Qiang, Cui, Chenhui, Zhong, Qianyun, Chen, Xingxing, Li, Zhen, Mariappan, Arumugam, Cheng, Yilong, Zhang, Zhicheng, and Zhang, Yanfeng
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- 2020
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24. Polythiourethane Covalent Adaptable Networks for Strong and Reworkable Adhesives and Fully Recyclable Carbon Fiber-Reinforced Composites.
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Cui, Chenhui, Chen, Xingxing, Ma, Li, Zhong, Qianyun, Li, Zhen, Mariappan, Arumugam, Zhang, Qiang, Cheng, Yilong, He, Gang, Chen, Xiaoming, Dong, Zhen, An, Le, and Zhang, Yanfeng
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- 2020
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25. Colonization and Development of the Fecal Microflora of South China Tiger Cubs (Panthera tigris amoyensis) by Sequencing of the 16S rRNA Gene
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Sun, Yanfa, Yao, Jie, Zhang, Min, Chen, Tengteng, Xu, Weihua, Fu, Wenyuan, Wu, Qiong, Li, Yan, Chen, Xingxing, Zhu, Yuting, Zhang, Xuemei, Liu, Lingyu, Chen, Donghong, Wang, Zhenyuan, You, Zhangjing, Zhang, Xuebing, Liu, Yi, Lin, Kaixiong, and Lin, Weiming
- Abstract
Postnatal colonization and development of the gut microbiota is linked to health and growth. A comprehensive understanding of the postnatal compositional changes and development of the microbial community is helpful to understand the gut health and improve the survival rate of South China tiger cubs (Panthera tigris amoyensis). Fecal samples from three tiger cubs were collected on the day of birth in 2018 (June 17–21 [G0], July 18 [G1], July 31 [G2], and August 7 [G3]). The 16S rRNA genes of the fecal microflora were sequenced. Results showed that 38 phyla, 58 classes, 134 orders, 272 families, and 636 genera of bacteria from 3,059 operational taxonomic units were identified from 12 fecal samples. The diversity and abundance of species of group G0 were significantly higher (p< 0.05 or 0.01) than those of groups G2 and G3. The predominant phylum was Proteobacteria in groups G0 and G1 (38.85% and 48%, respectively) and Firmicutes in groups G2 and G3 (71.42% and 75.29%, respectively). At the phylum level, the abundance of Deinococcus-Thermus was significantly decreased in groups G1, G2, and G3 as compared to group G0 (p< 0.05), while that of Firmicutes was significantly increased in groups G2 and G3 (p< 0.05). At the genus level, the abundance of Faecalibacterium, Ralstonia, and unidentified Rickettsialeswas significantly decreased in groups G1, G2, and G3 as compared with group G0 (p< 0.05), while that of Pseudomonaswas significantly decreased in groups G2 and G3 (p< 0.05). The composition and structure of fecal microbiota of South China tiger cubs changed after birth.
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- 2021
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26. On-Chip Multicolor Photoacoustic Imaging Flow Cytometry
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Jin, Tian, Zhang, Chen, Liu, Fei, Chen, Xingxing, Liang, Guangru, Ren, Fei, Liang, Suzi, Song, Chaolong, Shi, Jianbing, Qiu, Weibao, Jiang, Xingyu, Li, Kai, and Xi, Lei
- Abstract
On-chip imaging flow cytometry has been widely used in cancer biology, immunology, microbiology, and drug discovery. Pure optical imaging combined with flow cytometry to derive chemical, structural, and morphological features of cells provides systematic insights into biological processes. However, due to the high concentration and strong optical attenuation of red blood cells, preprocessing is necessary for optical flow cytometry while dealing with whole blood. In this study, we develop an on-chip photoacoustic imaging flow cytometry (PAIFC), which combines multicolor high-speed photoacoustic microscopy and microfluidics for cell imaging. The device employs a micro-optical scanner to achieve a miniaturized outer size of 30 × 17 × 24 mm3and ultrafast cross-sectional imaging at a frame rate of 1758 Hz and provides lateral and axial resolutions of 2.2 and 33 μm, respectively. Using a multicolor strategy, PAIFC is able to differentiate cells labeled by external contrast agents, detect melanoma cells with an endogenous contrast in whole blood, and image melanoma cells in blood samples from tumor-bearing mice. The results suggest that PAIFC has sufficient sensitivity and specificity for future cell-on-chip applications.
- Published
- 2021
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27. Earth-abundant coal-derived carbon nanotube/carbon composites as efficient bifunctional oxygen electrocatalysts for rechargeable zinc-air batteries
- Author
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Lu, Zhenjie, Yao, Songdong, Dong, Yanzeng, Wu, Dongling, Pan, Haoran, Huang, Xinning, Wang, Tao, Sun, Zhenyu, and Chen, Xingxing
- Abstract
Traditional energy resource i.e. natural coal is used to develop high-performance bifunctional oxygen electrodes in renewable energy conversion systems.
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- 2021
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28. An approach to effectively improve the interfacial bonding of nano-perfused composites by in situgrowth of CNTs
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Chen, Xingxing, Li, Ying, Wang, Ying, Song, Dingquan, Zhou, Zuowan, and Hui, David
- Abstract
Nano molding technology (NMT) has shown great potential in the preparation of metal/resin composites, which can integrate resin and metal into a lightweight, high-strength metal matrix composite. However, due to the poor interfacial bonding strength between metal and polymer, the application of the metal/polymer composites is limited. In this paper, we proposed a novel method to improve the bonding strength between Fe–Co–Ni alloy and epoxy resin by Nano Perfusion Technology (NPT), featuring in situgrowth of carbon nanotubes (CNTs) in the pores on anodized Fe–Co–Ni alloy porous surface, followed by a perfusion of epoxy resin throughout the pores that had been in situgrown CNTs. Due to the “anchor effect” of CNTs, the bonding strength between the epoxy and the alloy matrix is improved. The results showed that the interfacial bonding between the in situCNTs-modified alloy and the resin was significantly improved compared to the metal-resin composites surface treated with T-treatment in traditional method of NMT. The maximum interfacial bonding force of the alloy-CNTs/epoxy composite reached up to 691.80 N, which was 460, 315, and 267% higher than those by mechanical treatment, without CNTs and T-treatment, respectively. This work provides a new approach to protect metals or alloys from environmental corrosion, impact damage, and so on.
- Published
- 2021
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29. Hard carbon-based electrode boosts the performance of a solid-state symmetric supercapacitor
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Chu, Hongyu, Lu, Zhenjie, Man, Mengyao, Song, Shuaichao, Zhang, Hailing, Cheng, Junxia, Zhao, Xuefei, Duan, Jingui, Chen, Xingxing, and Zhu, Yaming
- Abstract
Hard carbon materials have gained extensive utilization in energy storage systems because of their stable chemical properties, unique lamellar arrangement, and significant interlayer spacing. In this study, we present a novel porous carbon electrode based on hard carbon to enhance the performance of a solid-state symmetric supercapacitor. This electrode was fabricated through an efficient and straightforward synthetic approach using natural asphalt as the precursor. The resulting carbon electrode exhibits remarkable features including a large surface area (2334.48 m2 g−1), a well-distributed pore size (mesopore ratio of 16.04 %), an appropriate oxygen content (18.11 %), and a lamellar structure. As a result, the as-prepared carbon electrode demonstrates a high specific capacitance of 325.82 F g−1at 0.5 A g−1, along with excellent rate capability, with coulombic efficiency ranging from 99.89 % at 0.5 A g−1to 98.92 % at 10 A g−1. Moreover, the assembled symmetrical all-solid-state supercapacitor utilizing this electrode achieves an energy density of 18.91 Wh Kg−1, an equivalent series resistance of 0.820 Ω, a relaxation time of 9.0 s, and self-discharge performance lasting up to 72 h. Notably, owing to its large layer spacing (0.391 nm), the electric double layer capacitor contributes as much as 94 %, indicating favorable electrical double layer characteristics. Our work not only showcases a high-performance electrode material but also contributes to the expanded application of hard carbon.
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- 2024
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30. Three–Four Photon Transition Mn(II) Complex Monitoring Lysosome-Related ATP in Real Time viaFluorescence Lifetime Imaging
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Li, Yaqin, Zhang, Qiong, Wang, Qiqi, Wang, Xuan, Wang, Junjun, Zhu, Xiaojiao, Chen, Xingxing, Wang, Sen, Sun, Xianshun, and Zhou, Hongping
- Abstract
Currently, in situmonitoring of the adenosine triphosphate (ATP) level in lysosomes is critical to understand their involvement in various biological processes, but it remains difficult due to the interferences of limited targeting and low resolution of fluorescent probes. Herein, we report a classic Mn(II) probe (FX2-MnCl2) with near-infrared (NIR) nonlinear (NLO) properties, accompanied by three–four photon transition and fivefold fluorescence enhancement in the presence of ATP. FX2-MnCl2combines with ATP through dual recognition sites of diethoxy and manganese ions to reflect slightly fluorescence lifetime change. Through the synergy of multiphoton fluorescence imaging (MP-FI) and multiphoton fluorescence lifetime imaging microscopy (MP-FLIM), it is further demonstrated that FX2-MnCl2displays lysosome-specific targeting behavior, which can monitor lysosome-related ATP migration under NIR laser light. This work provides a novel multiphoton transformation fluorescence complex, which might be a potential candidate as a simple and straightforward biomarker of lysosome ATP in vitrofor clinical diagnosis.
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- 2024
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31. Interactions of Catalytic Enzymes with n-Type Polymers for High-Performance Metabolite Sensors
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Ohayon, David, Renn, Dominik, Wustoni, Shofarul, Guo, Keying, Druet, Victor, Hama, Adel, Chen, Xingxing, Maria, Iuliana Petruta, Singh, Saumya, Griggs, Sophie, Schroeder, Bob C., Rueping, Magnus, McCulloch, Iain, and Inal, Sahika
- Abstract
The tight regulation of the glucose concentration in the body is crucial for balanced physiological function. We developed an electrochemical transistor comprising an n-type conjugated polymer film in contact with a catalytic enzyme for sensitive and selective glucose detection in bodily fluids. Despite the promise of these sensors, the property of the polymer that led to such high performance has remained unknown, with charge transport being the only characteristic under focus. Here, we studied the impact of the polymer chemical structure on film surface properties and enzyme adsorption behavior using a combination of physiochemical characterization methods and correlated our findings with the resulting sensor performance. We developed five n-type polymers bearing the same backbone with side chains differing in polarity and charge. We found that the nature of the side chains modulated the film surface properties, dictating the extent of interactions between the enzyme and the polymer film. Quartz crystal microbalance with dissipation monitoring studies showed that hydrophobic surfaces retained more enzymes in a densely packed arrangement, while hydrophilic surfaces captured fewer enzymes in a flattened conformation. X-ray photoelectron spectroscopy analysis of the surfaces revealed strong interactions of the enzyme with the glycolated side chains of the polymers, which improved for linear side chains compared to those for branched ones. We probed the alterations in the enzyme structure upon adsorption using circular dichroism, which suggested protein denaturation on hydrophobic surfaces. Our study concludes that a negatively charged, smooth, and hydrophilic film surface provides the best environment for enzyme adsorption with desired mass and conformation, maximizing the sensor performance. This knowledge will guide synthetic work aiming to establish close interactions between proteins and electronic materials, which is crucial for developing high-performance enzymatic metabolite biosensors and biocatalytic charge-conversion devices.
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- 2024
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32. H‑Bonding Supramolecular Hydrogels with Promising Mechanical Strength and Shape Memory Properties for Postoperative Antiadhesion Application.
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Yang, Yuxuan, Zhao, Xiaodan, Yu, Jing, Chen, Xiaojing, Chen, Xingxing, Cui, Chenhui, Zhang, Junjie, Zhang, Qiang, Zhang, Yanfeng, Wang, Shuang, and Cheng, Yilong
- Published
- 2020
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33. Extremely Tough, Puncture-Resistant, Transparent, and Photoluminescent Polyurethane Elastomers for Crack Self-Diagnose and Healing Tracking.
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Chen, Xingxing, Zhong, Qianyun, Cui, Chenhui, Ma, Li, Liu, Shuang, Zhang, Qiang, Wu, Youshen, An, Le, Cheng, Yilong, Ye, Shibo, Chen, Xiaoming, Dong, Zhen, Chen, Quan, and Zhang, Yanfeng
- Published
- 2020
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34. Improved impedance matching by multi-componential metal-hybridized rGO toward high performance of microwave absorption
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Xie, Jinlong, Jiang, Hunan, Li, Jinyang, Huang, Fei, Zaman, Ahsan, Chen, Xingxing, Gao, Dan, Guo, Yifan, Hui, David, and Zhou, Zuowan
- Abstract
Microwave-absorbing materials with good microwave absorption performance are of great interest for military applications and human health, which is threatened by electromagnetic radiation pollution. Herein, the design and synthesis of multi-componential metal-hybridized graphene composites via freeze drying and pyrolysis of ferrocene hydrazone complex precursor are reported. Various magnetic nanoparticles are loaded on reduced graphene oxide (rGO) via controlling their pyrolysis temperature. The complex electromagnetic parameters of these hybrids are therefore regulated by the hybrid components. Among them, rGO hybridized by the sea-island-like Fe2O3/Fe3O4/FeNi3multi-componential metals shows a good balance of dielectric and magnetic constants. Thus, the improved impedance matching with free space brings about a superior electromagnetic wave absorption performance, especially on the effective absorption bandwidth. The minimum reflection loss (RL) of the hybrids is as low as −40.3 dB at 11 GHz with the RL bandwidth of −10 dB being 4.55 GHz (from 9.25 to 13.8 GHz).
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- 2021
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35. Introduction of a Stable Radical in Polymer Capacitor Enables High Energy Storage and Pulse Discharge Efficiency
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Ma, Li, Zhang, Qiang, Cui, Chenhui, Zhong, Qianyun, Chen, Xingxing, Li, Zhen, Mariappan, Arumugam, Cheng, Yilong, Zhang, Zhicheng, and Zhang, Yanfeng
- Abstract
Flexible dielectrics with high energy density (Ue) and low energy loss (Ul) under elevated electric fields are especially attractive for the next-generation energy storage devices, e.g., high-pulse film capacitors. However, raising Ueby introducing high dielectric constant materials generally increases Ul, which is detrimental to the devices. To overcome this trade-off, a new strategy consisting of elevating electron polarization through the incorporation of 4-hydroxy-2,2,6,6-tetramethylpiperidin-N-oxy (TEMPO) units and capturing electrons with stable organic radicals is proposed. A series of flexible poly (dicyclopentadiene norbornene-ended 4-hydroxy-2, 2, 6, 6-tetramethylpiperidin-N-oxy) (PNB-DxTy) copolymers with excellent dielectric and physical properties, thermal stability, and processability, were prepared and their energy storage properties investigated. Specifically, dicyclopentadiene (DCPD) groups were designed to construct a cross-linked network, while the TEMPO groups offered a stable radical to capture electrons under the action of an electric field, which favored the enhancement of the dielectric constant, Young’s modulus, and breakdown strength of the polymers. Compared with commercially available state-of-the-art polymer dielectrics, e.g., biaxially oriented polypropylene (BOPP), PNB-Dx-Tydemonstrated an exceeding dielectric performance and low-cost potential. Importantly, a discharge energy density of 10.6 J/cm3with a high efficiency of 92% at 500 MV/m was achieved. The effective strategy revealed that the isolated stable radical in the low-polarity polymer matrix suppressed the energy loss and created a new paradigm for high-energy and low-loss flexible capacitors.
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- 2020
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36. Polythiourethane Covalent Adaptable Networks for Strong and Reworkable Adhesives and Fully Recyclable Carbon Fiber-Reinforced Composites
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Cui, Chenhui, Chen, Xingxing, Ma, Li, Zhong, Qianyun, Li, Zhen, Mariappan, Arumugam, Zhang, Qiang, Cheng, Yilong, He, Gang, Chen, Xiaoming, Dong, Zhen, An, Le, and Zhang, Yanfeng
- Abstract
The development of adhesives with superior optical and mechanical performance, solvent resistance, and reworkability is gaining increasing attention in recent years. However, traditional materials do not possess reprocessability and healing characteristics for sustainable development. Here, a superior dynamic polythiourethane (PTU) adhesive with high reprocessability was developed by introducing covalent adaptable networks (CANs). Specifically, dynamic thiocarbamate bonds (TCB) were used to prepare PTU CANs, which showed dramatically enhanced malleability and recyclability. The Young’s modulus of the material was 2.0 GPa and the tensile strength was 62.7 MPa. The reprocessing temperature of CANs was reduced to 80 °C while more than 90% of their mechanical properties were retained, even after being reprocessed several times. Moreover, the highly transparent and water-resistant PTU CANs featured an excellent bonding property and reworkability for various materials including glass, with a lap shear strength of 2.9 MPa, metal (5.1 MPa), and wood (6.3 MPa), compared with commercially available adhesives. Additionally, carbon fiber-reinforced composites constructed with PTU CANs were capable of being fully recycled and reused. Importantly, laminated glass with a toughened PTU–PU elastomer interface exhibited an outstanding impact fatigue-resistance behavior, sustaining thousands of impacts. These features demonstrate that PTU CANs show great potential as sustainable materials.
- Published
- 2020
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37. H-Bonding Supramolecular Hydrogels with Promising Mechanical Strength and Shape Memory Properties for Postoperative Antiadhesion Application
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Yang, Yuxuan, Zhao, Xiaodan, Yu, Jing, Chen, Xiaojing, Chen, Xingxing, Cui, Chenhui, Zhang, Junjie, Zhang, Qiang, Zhang, Yanfeng, Wang, Shuang, and Cheng, Yilong
- Abstract
Development of a physical barrier with mechanical properties similar to human smooth muscle and an on-demand degradation profile is crucial for the clinical prevention of postoperative adhesion. Herein, a series of supramolecular hydrogels (PMI hydrogels) composed of poly(ethylene glycol) (PEG), methylenediphenyl 4, 4-diisocyanate (MDI), and imidazolidinyl urea (IU, hydrogen bonding reinforced factor) with biodegradability and high toughness are reported to serve as physical barriers for abdominal adhesion prevention. The tensile fracture strength and strain of the PMI hydrogels could be adjusted in the ranges of 0.6–2.3 MPa and 100–440%, respectively, and their Young’s moduli (0.2–1.6 MPa) are close to that of human soft tissues like smooth muscle and skin tissue as well as they have outstanding shape memory properties. The PMI hydrogels show good cell and tissue biocompatibility, and the in vivo retention time is in accord with the needs for the postoperative antiadhesion physical barriers. Through an abdominal defect model on mice, this study shows that the PMI hydrogel can completely prevent tissue adhesion compared to the commercialized Seprafilm with high safety. Owing to the promising mechanical properties and good biocompatibility, the PMI hydrogels may be extended for various biomedical applications and the development of advanced flexible electronic devices.
- Published
- 2020
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38. Preparation and Characterization of Coal-Pitch-Based Needle Coke (Part III): The Effects of Quinoline Insoluble in Coal Tar Pitch
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Zhu, Yaming, Liu, Huimei, Xu, Yunliang, Hu, Chaoshuai, Zhao, Chunlei, Cheng, Junxia, Chen, Xingxing, and Zhao, Xuefei
- Abstract
High-temperature coal tar pitch is often used to produce high-quality needle coke. Its basic properties [such as favalue, β resin, and quinoline insoluble (QI) content] significantly affect the quality of the resulting needle coke. Refined pitch with faand β-resin values in the 0.95–0.98 and 13–16% ranges, respectively, is considered an excellent raw material for this purpose. The influence of QI content on the characteristics of coal-based needle coke is still not fully clarified in the literature. To analyze how QI content affects coal-based needle coke properties, this work used 10 different kinds of coal tar pitch (refined from the same source) with different QI contents for the needle coke production. We thoroughly analyzed optical microstructure and crystalline sizes, surface morphology and microstrength, true density, and coefficient of thermal expansion (CTE) of the resulting products. The high-temperature coal tar pitch with the QI content of <0.8% was a preferable raw material to obtain superior needle coke; it possessed higher density and microstrength, lower CTE, and graphitized more easily than cokes with other parameters.
- Published
- 2020
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39. Extremely Tough, Puncture-Resistant, Transparent, and Photoluminescent Polyurethane Elastomers for Crack Self-Diagnose and Healing Tracking
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Chen, Xingxing, Zhong, Qianyun, Cui, Chenhui, Ma, Li, Liu, Shuang, Zhang, Qiang, Wu, Youshen, An, Le, Cheng, Yilong, Ye, Shibo, Chen, Xiaoming, Dong, Zhen, Chen, Quan, and Zhang, Yanfeng
- Abstract
Ensuring material performance reliability and lifetime is crucial for practical operations. Small cracks on the material surface are often detrimental to its safe operation. This study describes the development of a hydrogen bond-rich puncture-resistant polyurethane elastomer with supertoughness. The as-prepared polyurethane transparent films feature high tensile break strength (57.4 MPa) and great toughness (228 MJ m–3). Additionally, a facile, low-cost, crack self-diagnostic approach through photoluminescence using a small luminous pen is reported. The materials efficiently achieved self-healing at 90 °C after the crack formation. The change of fluorescence intensity on the crack can be used to track the self-healing process. Therefore, this work provides a guideline for the material design of supertough, puncture-resistant, transparent, and healable elastomers and a crack self-diagnosis and healing approach.
- Published
- 2020
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40. Biofuel powered glucose detection in bodily fluids with an n-type conjugated polymer
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Ohayon, David, Nikiforidis, Georgios, Savva, Achilleas, Giugni, Andrea, Wustoni, Shofarul, Palanisamy, Tamilarasan, Chen, Xingxing, Maria, Iuliana Petruta, Di Fabrizio, Enzo, Costa, Pedro M. F. J., McCulloch, Iain, and Inal, Sahika
- Abstract
A promising class of materials for applications that rely on electron transfer for signal generation are the n-type semiconducting polymers. Here we demonstrate the integration of an n-type conjugated polymer with a redox enzyme for the autonomous detection of glucose and power generation from bodily fluids. The reversible, mediator-free, miniaturized glucose sensor is an enzyme-coupled organic electrochemical transistor with a detection range of six orders of magnitude. This n-type polymer is also used as an anode and paired with a polymeric cathode in an enzymatic fuel cell to convert the chemical energy of glucose and oxygen into electrical power. The all-polymer biofuel cell shows a performance that scales with the glucose content in the solution and a stability that exceeds 30 days. Moreover, at physiologically relevant glucose concentrations and from fluids such as human saliva, it generates enough power to operate an organic electrochemical transistor, thus contributes to the technological advancement of self-powered micrometre-scale sensors and actuators that run on metabolites produced in the body.
- Published
- 2020
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41. A MEMS-based opto-acoustic-fluidic system for cell imaging
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Wang, Hannan, Wang, Min, Jin, Tian, Liu, Fei, Chen, Xingxing, and Xi, Lei
- Published
- 2019
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42. Tunable and Processable Shape-Memory Materials Based on Solvent-Free, Catalyst-Free Polycondensation between Formaldehyde and Diamine at Room Temperature.
- Author
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Lei, Hengxin, Wang, Shengnan, Liaw, Der Jang, Cheng, Yilong, Yang, Xutong, Tan, Jidong, Chen, Xingxing, Gu, Junwei, and Zhang, Yanfeng
- Published
- 2019
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43. Photocatalytic one-step synthesis of Ag nanoparticles without reducing agent and their catalytic redox performance supported on carbon
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Shui, Lingling, Zhang, Guoxiu, Hu, Bin, Chen, Xingxing, Jin, Mingliang, Zhou, Guofu, Li, Nan, Muhler, Martin, and Peng, Baoxiang
- Abstract
Synthesis of silver nanoparticles (Ag NPs) with state-of-the-art chemical or photo-reduction methods generally takes several steps and requires both reducing agents and stabilizers to obtain NPs with narrow size distribution. Herein, we report a novel method to synthesize Ag NPs rapidly in one step, achieving typical particle sizes in the range from 5 to 15 nm. The synthesis steps only involve three chemicals without any reducing agent: AgNO3as precursor, polyvinylpyrrolidone (PVP) as stabilizer, and AgCl as photocatalyst. The Ag NPs were supported on carbon and showed excellent performance in thermal catalytic p-nitrophenol reduction and nitrobenzene hydrogenation, and as electrocatalyst for the oxygen reduction reaction.
- Published
- 2019
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44. Microwave-Assisted Synthesis of Co/CoOx Supported on Earth-Abundant Coal-Derived Carbon for Electrocatalysis of Oxygen Evolution
- Author
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Pan, Haoran, Wu, Dongling, Huang, Xinning, Xie, Kunpeng, He, Bingcai, Lu, Zhenjie, Liu, Penggao, Cheng, Junxia, Zhao, Xuefei, Masa, Justus, and Chen, Xingxing
- Abstract
The evident demand for hydrogen as the ultimate energy fuel for posterity calls for the development of low-cost, efficient and stable electrocatalysts for water splitting. Herein, we report the synthesis of Co/CoOx supported on coal-derived N-doped carbon via a simple microwave-assisted method and demonstrate its application as an efficient catalyst for the oxygen evolution reaction (OER). With the optimal amount of cobalt introduced into the N-doped coal-derived, the developed catalyst achieved overpotentials of 0.370 and 0.429 V during water oxidation at current densities of 1 mA cm[?]2 and 10 mA cm[?]2, respectively. There was no noticeable loss in the activity of the catalyst during continuous galvanostatic polarization at a current density of 10 mA cm[?]2 for a test period of 66 h. The synergistic interaction of the Co/CoOx moieties with the pyridinic and pyrollic nitrogen functional groups in the N-doped carbon, as well with the other heteroatoms species in the pristine coal favored enhancement of the OER electrocatalytic performance.
- Published
- 2019
45. Novel Inorganic-Based N-Halamine Nanofibrous Membranes As Highly Effective Antibacterial Agent for Water Disinfection
- Author
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Liu, Cui, Shan, Haoru, Chen, Xingxing, Si, Yang, Yin, Xia, Yu, Jianyong, and Ding, Bin
- Abstract
Novel superhydrophilic inorganic-based N-halamine nanofibrous membranes with high active chlorine contents, outstanding rechargeability, favorable water swelling resistance, and superior mechanical performance were prepared through the combination of electrospinning and sol–gel processing, which could be applied to the dynamic disinfection of bacteria-contaminated water with high disinfection efficiency, large processing flux, and long-term durability. The successful preparation of such silica nanofiber membranous N-halamine antimicrobial with intriguing properties would provide the reference for developing novel antimicrobial nanofibers for multifunctional applications.
- Published
- 2018
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46. Weekly Versus Triweekly Cisplatin-Based Chemotherapy Concurrent With Radiotherapy in the Treatment of Cervical Cancer: A Meta-Analysis.
- Author
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Chen, Xingxing, Zou, Haizhou, Li, Huifang, Lin, Ruifang, Su, Meng, Zhang, Wenyi, Zhou, Yongqiang, Zhang, Ping, Hou, Meng, Deng, Xia, and Zou, Changlin
- Subjects
CISPLATIN ,CANCER chemotherapy ,RADIOTHERAPY ,CERVICAL cancer treatment ,CANCER relapse - Abstract
Background: The aim of this study was to evaluate toxicity, compliance, recurrence and the survival of weekly and triweekly cisplatin-based concomitant chemoradiation in treatment of cervical cancer. Materials and Methods: The databases were searched from 1995 until 2015 to identify eligible studies on weekly versus triweekly cisplatin chemoradiotherapy. The data were analyzed by RevMan 5.3 software. Results: A total of 5 randomized controlled trials were included in this review. Weekly cisplatin regimen significantly reduced the incidence of Hematologic toxicity. However, there was no significantly different between the 2 arms in compliance, recurrence and the survival rate (all P >0.05). Conclusions: Weekly cisplatin regimen had the similar therapeutic effect as the triweekly cisplatin regimen but with less hematologic toxicity. Therefore, we recommend the weekly cisplatin 30 to 40 mg/m
2 chemoradiotherapy as the strong candidate for the optimal cisplatin dose and dosing schedule in the treatment of locally advanced cervical cancer. [ABSTRACT FROM AUTHOR]- Published
- 2017
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47. Co-Mn Hybrid Oxides Supported on N-Doped Graphene as Efficient Electrocatalysts for Reversible Oxygen Electrodes
- Author
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Lu, Zhenjie, Chen, Xingxing, Liu, Penggao, Huang, Xinning, Wei, Jiong, Ren, Zhong, Yao, Songdong, Fang, Zhigang, Wang, Tao, and Masa, Justus
- Abstract
Despite metal-air batteries possessing very high theoretical energy densities, inefficient reversibility of the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER) at the oxygen electrode undermines their rechargeability, which has slowed their market entry. Herein, we demonstrate a simple procedure for synthesis of a hybrid of MnO and metallic Co supported on N-doped graphene that exhibits activity and stability as a bifunctional ORR/OER catalyst, with a round trip ORR/OER overvoltage of 0.85 V, which remained constant for at least 70 h when cycling alternately, between oxygen evolution at a current density of 10 mA cm[?]2 and oxygen reduction at [?]1 mA cm[?]2. Insights into the key properties of the catalyst that influence its performance are proposed based on structural characterization by TEM, SEM, Raman spectroscopy, XRD and XPS. Besides MnO and metallic Co as the predominant crystalline species in the Co-Mn hybrid oxide, XPS revealed Mn3O4 and CoO rich surfaces, ascribed to oxidation of MnO and metallic Co due to atmospheric exposure. The synergetic interaction between the Co-Mn hybrid oxides and N-doped graphene, as well as Co-Mn interaction, favor improved ORR, OER and bifunctional ORR/OER performance of the catalyst.
- Published
- 2018
48. Groundwater micro-dynamic extraction and its response to seismic activity based on EMD
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Falco, Charles M., Jiang, Xudong, Wang, Jie, Chen, Xingxing, Kang, Bo, and Li, Xianri
- Published
- 2017
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49. Stroke and Activity Limitation in Chinese Adults 65 Years or Older
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Ewing, Alexander C., Li, Yaxi, Chen, Xingxing, Gallis, John, Su, Kehan, Turner, Elizabeth L., and Yan, Lijing L.
- Abstract
Differences in activity limitations between stroke survivors and people with other chronic conditions and how their levels of activity limitation vary by sociodemographic characteristics have not been well quantified.
- Published
- 2023
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50. Viola yedoensis Makino formula alleviates DNCB-induced atopic dermatitis by activating JAK2/STAT3 signaling pathway and promoting M2 macrophages polarization.
- Author
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Zeng, Hairong, Zhao, Bei, Zhang, Die, Rui, Xin, Hou, Xudong, Chen, Xingxing, Zhang, Benrui, Yuan, Yi, Deng, Hongping, and Ge, Guangbo
- Abstract
Background: Atopic dermatitis (AD), a common inflammatory skin disorder, severely affects the life quality of patients and renders heavy financial burden on patient's family. The Chinese medicine Viola yedoensis Makino formula (VYAC) has been widely used for treating various skin disorders. Previous studies have reported that VYAC is effective in relieving DNCB-induced AD and inflammation. However, the anti-inflammatory mechanism of VYAC is still ill-defined and poorly understood. This study aims to investigate the therapeutic effects of VYAC on DNCB-induced AD and to elucidate the underlying anti-inflammatory mechanisms.Methodology: VYAC were extracted with 70% ethanol and lyophilized for use. AD mice were established by DNCB. The therapeutic effects of VYAC were evaluated by oral administration VYAC (150, 300 and 600 mg/kg) daily in vivo. The histopathological and immunohistochemistry were used to analyze skin lesion and macrophages infiltration, RT-qPCR and Elisa were used to analyze the inflammatory factors in skin tissues and serum. To explore the underlying mechanism of VYAC against AD in vitro. RAW264.7 cells and bone-marrow-derived macrophages (BMDMs) were employed for macrophage polarization analysis. Flow cytometer, immunofluorescence and western blot were used to analyze M2 macrophages markers. STAT3 siRNA were transfected into both cells to validate the effects of VYAC-induced macrophages M2 polarization via JAK2/STAT3 signaling pathway.Results: VYAC ameliorated skin lesion of DNCB-induced AD mice by decreased clinical scores and epidermal thickness, decreased the level of pro-inflammatory factors (IL-1β, TNF-α and IL-18) and enhanced IL-10 anti-inflammatory factor level, inhibited macrophages infiltration and promoted M2 macrophages polarization in vivo. VYAC significantly promoted M2 macrophages polarization in vitro. It is observed that VYAC not only inhibited the phosphorylation of JAK2 and STAT3 in RAW264.7 cells and BMDMs, but also accelerated the translocation to the nucleus. What's more, VYAC reduced the polarization of M2 macrophage by activating JAK2/STAT3 signaling pathway was observed in both cells.Conclusions: Our findings demonstrate that VYAC significantly ameliorates skin lesion of DNCB-induced AD mice and reduces the levels of inflammatory factors by activating JAK2/STAT3 signaling pathway and promoting M2 macrophages polarization. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
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