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Traditional Chinese medicine plays a significant role in the treatment of the pandemic of coronavirus disease 2019 (COVID-19). Tanreqing Capsule (TRQC) was used in the treatment of COVID-19 patients in the Shanghai Public Health Clinical Center. This study aimed to investigate the clinical efficacy of TRQC in the treatment of COVID-19.

A series of guidelines concerning hypertension emphasize the importance of follow-up in patients’ management. The aim of this study was to assess the impact of routine follow-up on blood pressure (BP) control. A total of 1511 patients with hypertension aged ≥ 35 years were selected randomly from 17 communities in two cities and four townships located in Shandong and Jiangsu provinces in China. About half of the patients visited the community clinic four or more times yearly; follow-up was conducted by telephone for 43.3%. Forty-four point two percent of patients who did not visit a community clinic received telephonic follow-up; a higher percentage of telephonic follow-up was found in patients who visited community clinics frequently. Positive changes in BP level and BP control were associated with the number of clinical visits, while no significant correlations were found with telephonic follow-up. After adjustment for covariates, a higher number of clinic visits was associated with better BP control, with odds ratios of 1.628 (95% confidence interval (CI): 1.141–2.322), 1.472 (95% CI: 1.008–2.271), and 1.790 (95% CI: 1.154–2.778) for 4–6, 7–12, and >12 visits/year, respectively. Taking an antihypertensive drug showed a strong, positive association with the number of clinic visits (OR 1.747, 95% CI: 1.484–2.056). These data suggest that health care systems may achieve greater success by increasing the frequency of clinical visits and that the positive changes may be related to improvement in medication adherence. Routine follow-up by telephone was not significantly associated with BP level and BP control.

Pt/HfOx/Pt resistive switching devices with symmetric electrodes were fabricated. Bipolar resistive switching (RS) behaviors and unipolar behaviors were then observed under a positive/negative bias applied to the top electrode (TE). A comparison and analysis of bipolar/unipolar RS behaviors under different voltage polarities was then performed.The results demonstrated that bipolar RS was achieved via a drift of anion (O2-) under the electric field resulting in the rupture and recovery of filaments at the interface. When the filaments dissolved and formed at the interface near BE, the performance of the bipolar RS devices was better. However, for unipolar RS devices, when filaments dissolved and formed at the interface near TE, the performance was even better. These results indicated that a drift of O2- caused by electric field and a diffusion of O2- induced by Joule heat were the main reasons for unipolar RS. The different characteristics of the bipolar and unipolar devices can be attributed to the existence of a different number of defects at the active interface of the devices. This was where the rupture and recovery of filaments occurred. The results also indicate that the active interface is more important than other interfaces for RRAM performance.

Mental cutting process, a widespread process in the machining, which can produce the maximum number of burrs. Burr detection and deburring are crucially important to safe reliability of parts. In order to avoid the effects of subjective factors effectively, and improve the production efficiency and production automation, we introduced the machine vision technique. According to the universal burrs produced in the cutting process, this paper principally studied the image segmentation, burrs feature extraction, the improvement of adaptability based on digital image processing. The authors conclude that the algorithm applied in this paper can detect the burrs information effectively, laid a solid foundation for automatic polishing, with the certain practical value.

Based on literature review and logic analysis, we sorts out golf equipment including golf apparel, golf clubs and golf balls in this paper. We also describe the detailed evolution process of the related golf equipments, which will give people a comprehensive understanding of golf development. Another objective of this paper is to popularize golf culture, and give a guideline for the development of the domestic golf equipment market.

This paper presents an algorithm to measure geometric parameters of optical fibers based on Halcon. The algorithm enhances the contrast of the fiber image and uses canny edge detection operator to extract the contours of fiber cross section. In order to remove noise in the contour, this paper studies new methods, include setting the contour length range, whether each contour is circular or not and whether the center of the circular contour and the center of the fiber core is consistent or not. These methods remove most of the noise. Finally, the effective contours are merged and then approximated by circle and ellipse. According to the mathematical model, all parameters required can be obtained. Experiment results show that the algorithm accuracy meet the needs.

Now the overall operation of the intelligent building doesnt work as well as we expect. In this paper, we focus on design, construction and management problems of our intelligent building and put forward the corresponding countermeasures based on the analysis of these problems in order to promote a healthy development of the intelligent building.

Region of interest (ROI) play important roles in image analysis and processing areas. In order to solve the problems of large scale storage and transmission of ID photos, this paper presents an approach to extract the ROI of ID photos. A standard facial training database is established by these extracted images. PCA algorithm extracts facial feature values of the extracted images and applied them to facial recognition. Facial recognition algorithm is efficient to manage these ID photos.

This paper analyses the actual applications demand of the real-time PCB production quality management information system for the electronic product manufacturing enterprises, has established functional model for the real-time PCB production and quality management information system, and has used of mathematical statistics and mathematical logic principles, methods to analyzed of PCB production quality information, which was collected in real-time, finally, has established a Quality Information System PCB, this system achieves the various production processes and product quality tracking and retroactively for PCB.

Cyanobacteria blooms are constantly observed in the coastal waters and pose an enormous threat to public health, economy and ecological environment. The characteristics of blue algal bloom images and feature extraction procedures are analyzed in this paper. The pixel value of Cyanobacteria blooms color images has a significant difference from normal coastal waters images, particularly those of Hue and Saturation. A new method is proposed for Cyanobacteria blooms detection using dynamic K-means algorithm. Experimental results demonstrate the excellent practicability of the proposed detection method. Based on the pixel statistics, it can achieve a highly successful probability of detecting bloom images. Therefore, the proposed detection method can be expected to classify and detect Cyanobacteria blooms in monitoring and forecasting systems.

SIFT feature matching algorithm is hot in the field of the currently feature matching research, its matching with the strong ability can deal with the translation, rotation, affine transformation occurring between images , and it also have a stable image feature matching ability to the images filmed at any angle. SIFT algorithm is adopted in this paper, matching feature point through the scale space , calculating the histogram of detecting feature point neighborhood of gradient direction characteristic vector and generation to SIFT eigenvector and the key points similarity measure. From different setting threshold, scale scaling, rotating, noise on the experiment, the experiment result proves this algorithm in the above aspects has good robustness, suitable for mass characteristic database of rapid, accurate matching.

Objective To determine whether the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is linked to the risk of ischaemic stroke and circulating homocysteine (Hcy) levels in a Chinese population.Methods This case–control study recruited angiogram-diagnosed patients with ischaemic stroke and healthy control subjects. The plasma Hcy concentrations were measured and the MTHFRC677T gene polymorphism was genotyped. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the severity of the ischaemic stroke.Results This study recruited 198 patients with ischaemic stroke and 168 controls. The TT genotype conferred a higher risk for ischaemic stroke than the CC genotype (odds ratio of 3.563; 95% confidence interval [CI] 1.412, 4.350). The T allele was the predisposing allele for ischaemic stroke. Hcy had an area under the receiver operating characteristic (ROC) curve of 0.624 (95% CI 0.530, 0.758). The ROC for Hcy demonstrated its usefulness in predicting ischaemic stroke. Hcy levels were not associated with ischaemic stroke severity as measured by the NIHSS.Conclusion The MTHFRC677T gene polymorphism affects circulating Hcy levels. The MTHFRC677T gene polymorphism and hyperhomocysteinaemia may play important roles in predicting the risk of ischaemic stroke.

A solid acid material of high loading of sulfated zirconia on mesoporous silica SBA-15 has been successfully synthesized by a direct-synthesis under strong acidic condition. The materials were characterized by powder X-ray diffraction, N2adsorption−desorption, UV−visible diffuse reflectance spectroscopy, transmission electron microscopy (TEM), ICP-mass, and NH3temperature-programmed-desorption (TPD). The zirconia content and well-ordered mesostructure of SiO2−SZ are controllable by tuning the molar ratios of sulfate to zirconia and silica to zirconia. UV−visible spectra and TEM observations confirm the incorporation of zirconium (IV) onto the mesoporoes framework. Acidity is enhanced in comparison with unsupported sulfated zirconia. Much improved catalytic performance under mild temperature condition in the esterification of lauric acid and palmitic acid with the direct-synthesis SiO2−SZ catalyst was observed as compared to un-supported SZ. The good catalytic performance of the sulfated silica-zirconia materials is attributed to a higher dispersion of zirconia to give higher acid site density and also to better tolerance of water. The solid acid catalytic materials have many advantages over liquid acids in its environmentally friendliness and easy separation.

The article studies the construction and implementation of the mode of four threes of college physical education curriculums in China. It suggests that physical education should include three parts of class teaching, after-class sports participation, and campus sports culture. The article shows that the modes discussed can improve the quality of college physical education.

Objective To determine the associations between matrix metalloproteinase-2 (MMP-2, encoded by the MMP2gene) 1306C/T and 735C/T polymorphisms and first and recurrent ischemic stroke in a Chinese population.Methods Patients with first and recurrent ischemic stroke were included. Serum MMP-2 was measured, and MMP21306C/T and 735C/T polymorphisms were detected. The associations between MMP21306C/T and 735C/T polymorphisms and first and recurrent ischemic stroke were analyzed.Results Serum MMP-2 in patients with first and recurrent ischemic stroke was significantly higher compared with controls, and patients with recurrent ischemic stroke had higher MMP-2 than those with first ischemic stroke. The frequency of the CC genotype and C allele of MMP2735C/T was highest in patients with recurrent ischemic stroke, followed by patients with first ischemic stroke, and controls. Conversely, the genotype and allele of MMP21306C/T did not significantly differ between groups. The CC genotype of MMP2735C/T was independently associated with first and recurrent ischemic stroke (odds ratios = 1.45 and 1.64, respectively), as was the C allele of MMP2735C/T (odds ratios = 1.68 and 1.77, respectively).Conclusions The CC genotype and C allele of MMP2735C/T were associated with first and recurrent ischemic stroke in a Chinese population.

CD1 molecules are MHC-unlinked class Ib molecules consisting of classical (human CD1a–c) and non-classical subsets (human CD1d and murine CD1). The characterization of non-classical subsets of CD1 is limited due to the lack of reagents. In this study, we have generated two new anti-mouse CD1 monoclonal antibodies, 3H3 and 5C6, by immunization of hamsters with purified CD1 protein. These antibodies recognize CD1-transfected cells and have no reactivity to cells isolated from CD1−⧹− mice. Both antibodies precipitate the 52 kDa heavy chain and 12 kDa β2m from thymocytes and splenocytes by radio-immunoprecipitation. Deglycosylation of CD1 reduces molecular mass of the heavy chain by 7.5 kDa, which can be detected by 3H3 but not 5C6. 3H3 and 5C6 detect surface CD1 expression on cells from the thymus, spleen, lymph node and bone marrow, but not on intestinal epithelial cells. Developmentally, CD1 is expressed on thymocytes prior to TCR rearrangement and remains constant throughout thymic development. CD1 is expressed early in the fetal liver (day 14) and remains expressed in hepatocytes postnatally. These data support evidence of a role for CD1 in the selection and⧹or expansion of NK1+T cells of both thymic origin and extrathymic origin. Unlike classical class I molecules, murine CD1 levels are not affected by IFN-γ, but like human CD1b can be up-regulated by IL-4 and GM-CSF although only moderately. Similar to human CD1b, murine CD1 is found by immunofluorescence microscopy on the cell surface, and in various intracellular vesicles, including early and late endosomes. Localization in endocytic compartments indicates that murine CD1 may be capable of binding endocytosed antigens.

Heparin-binding epidermal growth factor (HB-EGF) gene transcription is rapidly activated in NIH 3T3 cells transformed by oncogenic Ras and Raf and mediates the autocrine activation of the c-Jun N-terminal kinases (JNKs) observed in these cells. A 1.7-kb fragment of the promoter of the murine HB-EGF gene linked to a luciferase reporter was strongly induced following activation of ΔRaf-1:ER, a conditionally active form of oncogenic human Raf-1. Promoter activation by ΔRaf-1:ER required a composite AP-1/Ets transcription factor binding site located between bp −974 and −988 upstream of the translation initiation site. In vivo genomic footprinting indicated that the basal level of occupancy of this composite AP-1/Ets element increased following ΔRaf-1:ER activation. Cotransfection of Ets-2 and p44 mitogen-activated protein (MAP) kinase expression vectors strongly potentiated HB-EGF promoter activation in response to ΔRaf-1:ER. Potentiated activation required both p44 MAP kinase catalytic activity and threonine 72 in the Pointed domain of Ets-2. Biochemical assays demonstrated the ability of the p42 and p44 MAP kinases to phosphorylate Ets-2 on threonine 72. Importantly, in intact cells, the kinetics of phosphorylation of Ets-2 on this residue closely mirror the activation of the p42 and p44 MAP kinases and the observed onset of HB-EGF gene transcription following ΔRaf-1:ER activation. These data firmly establish Ets-2 as a direct target of the Raf-MEK-MAP kinase signaling pathway and strongly implicate Ets-2 in the regulation of HB-EGF gene expression.

Objective To investigate the efficacy of low-dose sufentanil for preventing shivering and visceral traction pain during cesarean section under spinal anesthesia.Methods This was a prospective, randomized, controlled study. A total of 112 full-term parturients who underwent elective caesarean delivery were randomly divided into two groups. Group R received 0.75% isobaric ropivacaine intrathecally and group RS received 0.75% isobaric ropivacaine plus 5 µg sufentanil intrathecally.Results There were no significant differences in the maximum sensory block time, motor block time, duration of the surgery, and heart rate, mean arterial pressure, and blood oxygen saturation before and 1, 5, and 10 minutes after spinal anesthesia, and at the end of the surgery between the two groups. Shivering was significantly more common in group R (n = 30) than in group RS (n = 8). The incidence of visceral traction pain in group R (46.43%) was significantly higher than that in group RS (14.29%). There was no significant difference in the newborns’ Apgar scores between the groups.Conclusion Adding low-dose sufentanil to ropivacaine can significantly reduce the incidence of shivering and visceral traction pain after spinal anesthesia.

ABSTRACTBackgroundCardiovascular diseases (CVDs) are the leading causes of death in China. Little is known about the CVD burden and risk factors in Henan Province, China.ObjectiveTo analyze the CVD burden and main risk factors between 1990 and 2017 in the Henan Province in China.MethodsThe methodological framework and analytical strategies adopted in the Global Burden of Disease Study 2017 were used.Results(1) Age-standardized mortality rate attributed to CVDs increased from 355.0 per 100,000 persons in 1990 to 364.1 per 100,000 persons in 2017 in Henan. (2) Age-standardized disability adjusted life years (DALYs) rate fell by 3.9% from 1990 to 2017. However, the number of DALYs attributed to CVDs increased by 75.9% from 4.2 million person-years in 1990 to 7.3 million person-years in 2017. (3) The age-standardized years lived with disability (YLDs) rate increased by 27.5% from 1990 to 2017. However, years of life lost (YLLs) rate decreased by 6.7% from 1990 to 2017. The contribution of YLLs to the DALYs decreased from 91.4% in 1990 to 89.2% in 2017. (4) Stroke (52.3%) and ischemic heart diseases (38.8%) accounted for 91.1% of total CVDs DALYs among adults in 2017. (5) Dietary factors such as high intake of sodium, alcohol use and low intake of fruits, high systolic blood pressure, and tobacco use were the top risk factors for CVDs, and the estimated population attributable fraction in 2017 was 69.4%, 56.7% and 25.2%, respectively.ConclusionsThe absolute burden of CVDs in Henan is still high, although age-standardized DALYs declined between 1990 and 2017. The prevention and control of stroke and ischemic heart diseases should focus on a few modifiable risk factors which mainly contributed to the burden of CVDs, such as dietary factors, high systolic blood pressure, and tobacco use.

To observe the early interventions of traditional Chinese Medicine (TCM) on the conversion time of nucleic acid in patients with coronavirus disease 2019 (COVID-19), and find possible underlying mechanisms of action.

With the rapid development of the intelligent building in China, Intelligent building energy consumption has become a social and economic development in a strategic issue that can not be ignored in our society. In this paper, we proposed the energy saving measures in central air conditioning and ventilation system and lighting system of large-scale intelligent building building automation (BA) system from four aspects.

We hypothesized that exclusively breast-fed, white full-term infants do not require vitamin D supplements. We studied in a randomized, double blind fashion, 20 term, white infants fed exclusively human milk for 6 mos. 10 received 400 IU/day D2(VitD) and 10 received placebo (NoVitD). Serum concentrations of 25-OHVitD2, 25-OHVitD2. and 1, 25(OH)2VitD as well as bone mineral content (BMC) or the radius were measured at birth, 6 wks, 12 wks, and 26 wks of age. Sunshine exposure (minimal erythemic dosas [MED] of ultraviolet B light [UVB]) was monitored with polysulphone dosimeters. 250HD2(±SD) was higher (p<.01) in VitD vs. NoVitD (32.9±8.9 vs 2.3±1 7 ng/ml at 12 wks and 24.7±11.2 vs 2.3±1.5 at 26 wks). However, 25-OHD3(synthesized in skin by UVB) was lower (p<.05) in VitD vs NoVitD (8.75±8.8 vs 19.9±11.2 ng/ml at 12 wks and 13.7±12.1 vs 25.7±10.5 at 26 wks), though mean weekly sunshine exposure did not differ in the groups (0.3±0.4 vs 0.2±0.3 MED's/wk). 1,25(OH)2VitD was similar in the groups at 12 wks (42.4±10.4 vs 41.5±12.3 pg/ml) and 26 wks (38.7±8.2 vs 37.2±8.7). BMC did not differ in the groups at 12 wks (VitD=80±12 mg/cm, NoVitD = 87±15 mg/cm) or 26 wks (Vit D=89±17 mg/cm, NoVitD=101±18 mg/cm). We conclude that white term, breast fed infants in Wisconsin do not need supplemental VitD as assessed by serum l,25(OH2Vit D and BMC, despite low sunshine exposure. This maybe due to NoVitD having higher serum 25OHD and thus a higher rate of synthesis and/or utilization of VitD3from the skin compared to VitD infants.