11 results on '"Cammarata, Francesco P."'
Search Results
2. Surgical site infections caused by multi-drug resistant organisms: a case–control study in general surgery
- Author
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Foschi, Diego, Yakushkina, Al’ona, Cammarata, Francesco, Lamperti, Giulia, Colombo, Francesco, Rimoldi, Sara, Antinori, Spinello, and Sampietro, Gianluca M.
- Abstract
Multi-drug resistant organisms (MDR-Os) are emerging as a significant cause of surgical site infections (SSI), but clinical outcomes and risk factors associated to MDR-Os-SSI have been poorly investigated in general surgery. Aims were to investigate risk factors, clinical outcomes and costs of care of multi-drug resistant organisms (MDR-Os-SSI) in general surgery. From January 2018 to December 2019, all the consecutive, unselected patients affected by MDR-O SSI were prospectively evaluated. In the same period, patients with non-MDR-O SSI and without SSI, matched for clinical and surgical data were used as control groups. Risk factors for infection, clinical outcome, and costs of care were compared by univariate and multivariate analysis. Among 3494 patients operated on during the study period, 47 presented an MDR-O SSI. Two control groups of 47 patients with non-MDR-O SSI and without SSI were identified. MDR-Os SSI were caused by poly-microbial etiology, meanly related to Gram negative Enterobacteriales. MDR-Os-SSI were related to major postoperative complications. At univariate analysis, iterative surgery, open abdomen, intensive care, hospital stay, and use of aggressive and expensive therapies were associated to MDR-Os-SSI. At multivariate analysis, only iterative surgery and the need of total parenteral and immune-nutrition were significantly associated to MDR-Os-SSI. The extra-cost of MDR-Os-SSI treatment was 150% in comparison to uncomplicated patients. MDR-Os SSI seems to be associated with major postoperative complications and reoperative surgery, they are demanding in terms of clinical workload and costs of care, they are rare but increasing, and difficult to prevent with current strategies.
- Published
- 2022
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3. Transcriptional modulations induced by proton irradiation in mice skin in function of adsorbed dose and distance
- Author
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Licursi, Valerio, Wang, Wei, Di Nisio, Elena, Cammarata, Francesco P., Acquaviva, Rosaria, Russo, Giorgio, Manti, Lorenzo, Cestelli Guidi, Mariangela, Fratini, Emiliano, Kamel, Gihan, Amendola, Roberto, Pisciotta, Pietro, and Negri, Rodolfo
- Abstract
Hadron therapy by proton beams represents an advanced anti-cancer strategy due to its highly localized dose deposition allowing a greater sparing of normal tissue and/or organs at risk compared to photon/electron radiotherapy. However, it is not clear to what extent non-targeted effects such as transcriptional modulations produced along the beamline may diffuse and impact the surrounding tissue. In this work, we analyze the transcriptome of proton-irradiated mouse skin and choose two biomarker genes to trace their modulation at different distances from the beam’s target and at different doses and times from irradiation to understand to what extent and how far it may propagate, using RNA-Seq and quantitative RT-PCR. In parallel, assessment of lipids alteration is performed by FTIR spectroscopy as a measure of tissue damage. Despite the observed high individual variability of expression, we can show evidence of transcriptional modulation of two biomarker genes at considerable distance from the beam’s target where a simulation system predicts a significantly lower adsorbed dose. The results are compatible with a model involving diffusion of transcripts or regulatory molecules from high dose irradiated cells to distant tissue’s portions adsorbing a much lower fraction of radiation.
- Published
- 2021
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4. Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
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Knight, Stephen R, Shaw, Catherine A, Pius, Riinu, Drake, Thomas M, Norman, Lisa, Ademuyiwa, Adesoji O, Adisa, Adewale O, Aguilera, Maria Lorena, Al-Saqqa, Sara W, Al-Slaibi, Ibrahim, Bhangu, Aneel, Biccard, Bruce M, Brocklehurst, Peter, Costas-Chavarri, Ainhoa, Chu, Kathryn, Dare, Anna, Elhadi, Muhammed, Fairfield, Cameron J, Fitzgerald, J Edward, Ghosh, Dhruv, Glasbey, James, van Berge Henegouwen, Mark I., Ingabire, J.C. Allen, Kingham, T Peter, Lapitan, Marie Carmela, Lawani, Ismaïl, Lieske, Bettina, Lilford, Richard, Martin, Janet, Mclean, Kenneth A, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pinkney, Thomas, Qureshi, Ahmad Uzair, Ramos-De la Medina, Antonio, Riad, Aya, Salem, Hosni Khairy, Simões, Joana, Spence, Richard, Smart, Neil, Tabiri, Stephen, Thomas, Hannah, Weiser, Thomas G, West, Malcolm, Whitaker, John, Harrison, Ewen M, Gjata, Arben, Modolo, Maria Marta, King, Sebastian, Chan, Erick, Nahar, Sayeda Nazmun, Waterman, Ade, Vervoort, Dominique, Lawani, Ismaïl, Bedada, Alemayehu Ginbo, De Azevedo, Bernardo, Figueiredo, Ana Gabriela, Sokolov, Manol, Barendegere, Venerand, Ekwen, Gerald, Agarwal, Arnav, Dare, Anna, Liu, Qinyang, Camilo Correa, Juan, Malemo, Kalisya Luc, Bake, Jacques, Mihanovic, Jakov, Kuncarová, Kamila, Orhalmi, Julius, Salem, Hosni, Teras, Jyri, Kechagias, Aristotelis, Arnaud, Alexis P, Lindert, Judith, Tabiri, Stephen, Kalles, Vasileios, Aguilera-Arevalo, Maria-Lorena, Recinos, Gustavo, Baranyai, Zsolt, Kumar, Basant, Neelamraju Lakshmi, Harish, Zachariah, Sanoop Koshy, Alexander, Philip, Kumar Venkatappa, Sunil, Pramesh, C, Amandito, Radhian, Fleming, Christina, Ansaloni, Luca, Pata, Francesco, Pellino, Gianluca, Altibi, Ahmed M., Nour, Ibrahim, Hamdun, Intisar, Elhadi, Muhammed, Ghellai, Ali M., Venskutonis, Donatas, Poskus, Tomas, Zilinskas, Justas, Whitaker, John, Malemia, Precious, Tew, Yong Yong, Borg, Elaine, Ellul, Sarah, Ramos-De la Medina, Antonio, Wafqui, fatima Zahraa, Borowski, David W, van Dalen, Anne Sophie, Wells, Cameron, Adamou, Harissou, Ademuyiwa, Adesoji, Adisa, Adewale, Søreide, Kjetil, Qureshi, Ahmad Uzair, Al-Slaibi, Ibrahim, Al Saqqa, Sara, Alser, Osaid, Tahboub, Haya, Segovia Lohse, Helmut Alfredo, Shu Yip, Sebastian, Lapitan, Marie Carmela, Major, Piotr, Simões, Joana, Sampaio Soares, António, Bratu, Matei Razvan, Litvin, Andrey, Vardanyan, Armen, Allen Ingabire, JC, Costas-Chavarri, Ainhoa, Gudal, Ahmad, Albati, Naif, Juloski, Jovan, Lieske, Bettina, Rems, Miran, Rayne, Sarah, Van Straten, Stephanie, Moodley, Yoshan, Chu, Kathryn, Moore, Rachel, Ortega Vázquez, Irene, Ruiz-Tovar, Jaime, Senanayake, Kithsiri Janakantha, Thalgaspitiya, Sujeewa Priyantha Bandara, Omer, Omer Abdelbagi, Homeida, Anmar, Cengiz, Yucel, Clerc, Daniel, Alshaar, Muhammad, Bouaziz, Hanen, Altinel, Yuksel, Doe, Matthew, Freigofer, Maryna, Teasdale, Ella, Kabariti, Rakan, Clements, Joshua Michael, Knight, Stephen Richard, Ashfaq, Ahsan, Azodo, Ijeoma, Wagner, Gabriela, Trostchansky, Ivan, Maimbo, Mayaba, Linyama, David, Nina, Helidon, Zeko, Amanda, Fermani, Claudio Gabriel, Modolo, Maria Marta, Villalobos, Santiago, Carballo, Federico, Farina, Pablo, Guckenheimer, Sebastian, Dickfos, Marilla, Ajmera, Ankit, Chong, Chester, Gourlay, Ralph, Hussaini, Sikandar, Lee, Yi Jia, Majid, Adeeb, Martin, Peter, Miles, Rebecca, Morris, Owen James, Phua, Jamie, Ridley, William, Saluja, Tarunpreet, Tan, Ryan Renxin, Teh, Jen, Wells, Anna, Arora, Bharti, Dollie, Qaasim, Ho, Debbie, Ma, Yanru, Perera, Omattage Mahasha, Truong, Anthony, Dawson, Amanda Caroline, Lim, Bryan, Pahalawatta, Upuli, Phan, Jacqueline, Woon-Shoo-Tong, Xiao-Ming Sarah, Yeoh, Andrea, Charman, Lillian, Drane, Andrew, Laura, Sharon, Lo, Charmaine Chu Wen, Mozes, Amy, Poon, Rita, Tan, Hao Han, Wall, Ellen, Chopra, Prakshi, De Giovanni, Jasmine, Dhital, Bal, Draganic, Brian, Duller, Alexander, Gani, Jonathan, Goh, Yao Kuan, Jeong, Jun Young, McManus, Brendan, Nagappan, Prakash, Pockney, Peter, Rugendyke, Anya, Sarrami, Mahsa, Smith, Stephen, Wills, Vanessa, Wong, Hsu Ven, Ye, Geoffrey, Zhang, Geoffrey, Brooker, Ethan, Feng, Daniel, Lau, Bonnie, Ngai, Carlin, Birks, Sarah, Gyorki, David, Otero de Pablos, Jaime, Abbosh, Ali, Gillespie, Chris, Mahmoud, Ahmed, Kwan, Bianca, Lawson, Joshua, Warwick, Andrea, Bingham, Janne, Cockbain, Andrew J, Dudi-Venkata, Nagendra Naidu, Ellaby-Hall, Jordan, Finlay, Ben, Humphries, Emily, Pisaniello, Jade, Pisaniello, Monique, Salih, Salma, Sammour, Tarik, Abd Wahab, Haidar Hadri, De Silva, April, Hayward, Nicola, Iyer, Kartik, Maddern, Guy, Prevost, Gian Andrea, Annapureddy, Naga, Settipalli, Krishna Pranathi, Yeo, Jeremy, Hempenstall, Lucy, Pham, Lily, Purcell, Shaun, Talavera, Cherry, Vaska, Ashish I, Chaggar, Gurpreet, Chrapko, Phillip, Cocco, Annelise, Coulter-Nile, Sarah Michelle Crystal Jade, Ctercteko, Grahame, French, James, Gong, Houchen, Gosselink, Martijn, Jegathees, Thuvarahan, Jin, Ivan, Kalachov, Michelle, Kiefhaber, Kathryn, Lee, Katherine, Luong, Jason, Phan, Steven, Pleass, Henry, Veale, Kelly, Zeng, Zhi, Au, Angela, DeBiasio, Ashe, Deng, Idy, Myooran, Jananee, Nair, Amrita, Stewart, Peter, Stift, Anton, Unger, Lukas Walter, Wimmer, Kerstin, Ahmed, Nabila, Hasan, Syed, Rahman, Saber, O'Shea, Margaret, Padmore, Greg, Peters, Adrian, Perduca, Pietro, Pulcina, Guenda, Tinton, Nicolas, Buxant, Frederic, Dabin, Elsa, Garofalo, Giulia, Dossou, Francis, Lawani, Ismaïl, Gnangnon, Freddy Houehanou Rodrigue, Imorou Souaibou, Yacoubou, Bedada, Alemayehu Ginbo, Motlaleselelo, Pako, Tlhomelang, Omphile, Lima Buarque, Igor, Mendonça Ataíde Gomes, Gustavo, Vieira Barros, Aldo, Batashki, Ilia, Damianov, Nikolai, Stoyanov, Vladislav, Dardanov, Dragomir, Maslyankov, Svilen, Petkov, Plamen, Sokolov, Manol, Todorov, George, Zhivkov, Evgeni, Akisheva, Aygulya, Castilla Moreno, Miguel Angel, Genov, Geno, Ilieva, Ivelina, Ivanov, Tsvetomir, Karamanliev, Martin, Khan, Azhar, Mitkov, Emil, Yotsov, Tsanko, Atanasov, Boyko, Belev, Nikolay, Slavchev, Mihail, Nsengiyumva, Carlos, Jones, Elgan, Stock, Simon, Ekwen, Gerald, Kyota, Steve, Brown, James, Mabanza K., Tresor, Nigo Samuel, Lemery, Otuneme, Chidi, Prosper, Ngwang, Umenze, Franklin, Boutros, Marylise, Caminsky, Natasha, Dumitra, Sinziana, Garfinkle, Richard, Morency, Dominique, Salama, Ebram, Banks, Alexander, Ferri, Lorenzo, He, Haitian, Katz, Amit, Liberman, Alexander Sender, Meterissian, Sarkis, Pang, Allison, Parvez, Elena, Agarwal, Arnav, Dare, Anna, Hameed, Usmaan, Osman, Fahima, Sequeira, Sangita, Coburn, Natalie, Dare, Anna, Jaffer, Alisha, Karanicolas, Paul, Mosseler, Matthew, Musselman, Reilly, Liu, Xinyuan, Yip, Ching Wan, Garces-Otero, Juan Sebastian, Guzman, Carolina, Sierra, Sebastian, Uribe Valencia, Andres, Cabrera Rivera, Paulo Andrés, Camelo, Saul, Gonzalez, Andrea, González-Orozco, Alejandro, Mosquera Paz, Manuel Santiago, Perez Rivera, Carlos J-, Gonzalez, Felipe, Isaza-Restrepo, Andres, Nino- Torres, Laura, Arias Madrid, Natalia, Mendoza Arango, Maria Clara, Sierra, Sebastian, Bake, Jacques, Tsandiraki, Justin, Jemendžic, Damir, Kocman, Branislav, Šuman, Oliver, Canic, Renata, Jurišic, Darko, Karakas, Ivana, Krizanovic Rupcic, Ana, Pitlovic, Vlatka, Samardžic, Josip, Kopljar, Mario, Bacic, Ivan, Domini, Edgar, Karlo, Robert, Mihanovic, Jakov, Miljanic, Danijela, Simic, Andrea, Ahmed, Mariam, Al Nassrallah, Majdi, Altaf, Rabiya, Amjad, Talal, Eltoum, Ruba, Haidar, Heba, Hassan, Alhassan, Khalil, Omar, Qasem, Marwan, Ramesh, Rommel, Sajith, Gautham, Wisal, Maham, Žatecký, Jan, Bujda, Michele, Jirankova, Katerina, Paclik, Ales, Abdallah, Aya, Abdulgawad Almogy, Mariam, Ayman El-sawy, Esraa, ElFayoumy, Ahmed Moustafa, Elghareeb, Nourhan, Esmat, Nourhan Ahmed, Fadel, Ahmed, Habater, Abdullah, Hamdy, Heba, Hefni, Amr, Kamal, Marwa, Mohamed Abobakr, Norhan, Sayed, Ahmed, Shaker, Nancy, Taha, Ehab, Tharwat, Hoda, Zakaria, Omar, Abdelmotaleb, Ibrahem, Al-Dhufri, Ali, Al-Himyari, Hamza S., El sheikh, Enas, Eldmaty, Asmaa, Elkhalawy, Aya, M.Elkhashen, Ahmed, Magdy, Kithara, Mostafa, Safa, Sadia, Habib Doutoum, Saleh, Mohamed mahmoud, Samir, Dina, Yahia Mohamed Ali, Mohamed, A. Nassar, Mahmoud, Abdelhady, Samar, Abdelrazek, Aly, Abdelsalam, Israa, El-Sawy, Aya, Essam, Eman, Gadelkarim, Mohamed, Ghaly, Khaled, Hassabalnaby, Mohamed, Masarani, Rana, Mohamed Shaaban, Nourhan, Sabry, Ahmed, Salem, Menatalla, Soliman, Nourhan Akram, Zahran, Diaaaldin, Abou El.soud, Moustafa Ramadan, Badr, Esraa Tarek, Borham, Hala, Elmeslemany, Nehal, Elsayed, Mohammad, Elsherif, Fawzia, Eslam, Sara, Gaber, Gehad, Ibrahim, Sondos, Kamh, Yara, Mahmoud, Abdelrahman, Mohamed, Shimaa gamal, Morshedy, Eman, Omar, Cinderella, Salem Soliman, Fatima, Abdelkawy, Shaza, Abdelmohsen, Naglaa, Abdelshakour, Mahmoud, Dahy, Ahmed, Gamal, Norhan, Gamal, Mohammed, Hasan, Ahmad, Hetta, Helal, Mousa, Nehad, Omar, Mohamed, Rabie, Somia, Saad, Mahmoud, Saleh, Bakeer, Sayed Mohamed, Marwa, Shawqi, Muhammad, Abdelhady Mousa, Heba, Alnoury, Mostafa, Elbealawy, Mohamed, Elshafey, Ahmed, Essam Ibrahim El Desouki Muhammad Ahmed, Muhammad, Ghonaim, Mennatullah, Hgag, Fawzy, Ibrahim, Mohamed, Morsy, Mahmoud, Reda Loaloa, Mohamed, Refaat, Ahmed, Samir, Hadeer, Shahien, Fatma, Sobhy, Mohamed, Sroor, Fathy, Abdellatif, Esraa, Adel, Marina, Afifi, Amr Abdelghani, Afifi, Eman, Antaky, Marco, Dawoud, Amr, El Zoghby, Naira, El-remaily, Amira, Elzanfaly, Ali Abdelazez, Gadallah, Ahmed, Gamal, Fatma Alzahraa, Hashem, Omar, Medhat Youssef, Shrouk, Muhammad Attyah, Aliaa, Munir, Malak, Shazly, Omar, Taha, Esraa, Wilson, Karim, Adel, Sawsan, Ali, Asmaa, Eid, Esraa, Elhelow, Esraa, Elmahdy, Marwa, Elshatby, Bassant, Hossam el-din Zakaria, Amany, Hossny, Ahmad, Ibrahim, Eman, M.Yonis, Ahmed, Metwalli, Maram, Yousry, Basant, Zid, Esraa, A Yacoub, Mina, Abdelhakim, Ahmed, Abouelsoad, Nervana, Alkhatib, Mo'min, Ashraf, Ahmed, Ashraf, Alaa, Elazab, Yasmin, Elfanty, Mahmoud, Elkabir, Osama, Elsayed, Mai, Elshimy, Ahmed, Elsobky, Hager, Eskander, John, Gad, Ahmed, Hamsho, Ward, Khaled Abdelwahed, Noura, Magdy, Menna, Moharam, Dalia, Osama, Abeer, Ramadan, Shereen, Roum, Radwa, Sayed, Taqwa, Shehada, Tarneem, Zidan, Ahmed Mohy, Abbas, Khalid, Ali, Amr, Attia, Mohamed, Balata, Mohamed, El Nakeeb, Ayman, Elewaily, Mohamed Ibrahim Elsayed, Elfallal, Ahmed, Elfeki, Hossam, Elkhadragy, Ahmed, Emile, Sameh, Ezzat, Helmy, Hosni, Hasnaa, Mansour, Islam, Omar, Waleed, Othman, Gehad, Sadek, Kareem, Shalaby, Mostafa, Shehab-Eldeen, Noura, Anas khalifa, Rawda, Badr, Helmy, Eldeep, Mostafa, Eldeep, Ahmed, Eldoseuky mohammed, Amany, Khallaf, Salwa, Magdy Hegazy, Eman, Mahmoud, Rokia, Mikhail, Pola, Morsi, Mahmoud, Mowafy, Sara, Raafat, Dina, Safy, Amina, Sera, Marwa, Sera, Ahmed shible, AbdAllah, Mostafa Salim Mohamed, Abdelkader, Muhammad, Abdou, Abdulrahman Osama, Ahmed, Ahmedgaber, Gaafar, Shireen, Ibrahim negm, Fatma, Lapic, Mina, Maher, Ahmed, Mahmoud, Hagar, Mostafa, Ahmed, Samir, Mohamed, Samy, Fatma, Semeda, Nourhan, Shalaby, Hind I., El-taweel, Alaa, Galal Elnagar, Ahmed, Hemidan, Ahmed Gamal, Hussein, Mohamed, Kandil, Ahmed. A., Moawad, Mf, Nasser Hamamah, Ayat Allah, Soliman, Mostafa, Abdelkhalek, Mohamed, Abdelmaksoud Tawakel, Noura, Abdelwahed, Ahmed Mohamed, Abdou, Alrawy, Atallah, Khalid, Elsherbeny, Mohammed Yasser, Emara, Eman, Hamdy, Mohamed, Hamdy, Omar, Haron, Amira, Ismail, Salma, Metwally, Islam Hany, Mohamed Hamed Elgaml, Nihal, Nassar, Ahmed, Refky, Basel, Sadek, Mirna, Saleh, Mahmoud, Yunes, Asmaa, Zakaria, Mai, Zuhdy, Mohammed, Fayed, Notila, Mohammed, Mohammed Mustafa Hassan, Kütner, Sander, Melnik, Priit, Seire, Indrek, Teras, Jyri, Ümarik, Toomas, Ainoa, Eppu, Eerola, Verner, Koppatz, Hanna, Koskenvuo, Laura, Sallinen, Ville, Takala, Sini, Katunin, Jevgeni, Kechagias, Aristotelis, Turunen, Arto, Christou, Niki, Mathonnet, Muriel, Lavoue, Vincent, Nyangoh Timoh, Krystel, Soulabaille, Lucie, Lesourd, Romain, Merdrignac, Aude, Sulpice, Laurent, André, Benoît, Chantalat, Elodie, Vaysse, Charlotte, Dousset, Bertrand, Gaujoux, Sebastien, Martin, Gregory, Clonda, Octavian, Juodis, Domantas, Kienle, Klaus, Mravik, Andras, Palmer, Samuel, Szabadhegyi, Gabor, Agbeko, Anita Eseenam, Gyabaah, Solomon, Gyamfi, Frank Enoch, Naabo, Nuhu, Owusu senior, Atta, Yorke, Joseph, Owusu, Frank, Abantanga, Francis, Anyomih, Theophilus Teddy Kojo, Muntaka, Abdul-Jalilu Mohammed, Owusu Abem, Emmanuel, Sheriff, Mohammed, Tabiri, Stephen, Wondoh, Paul M., Balalis, Dimitrios, Korkolis, Dimitrios, Gkiokas, Georgios, Pantiora, Eirini, Theodosopoulos, Theodosios, Ioannidis, Argyrios, Konstantinidis, Konstantinos, Konstantinidou, Sofia, Machairas, Nikolaos, Paspala, Anna, Prodromidou, Anastasia, Chouliaras, Christos, Papadopoulos, Konstantinos, Baloyiannis, Ioannis, Mamaloudis, Ioannis, Tzovaras, George, Akrida, Ioanna, Argentou, Maria-Ioanna, Germanos, Stylianos, Iliopoulos, Evangelos, Maroulis, Ioannis, Skroubis, George, Theofanis, George, Chatzakis, Christos, Ioannidis, Orestis, Loutzidou, Lydia, Kalles, Vasileios, Karathanasis, Panagiotis, Michalopoulos, Nikolaos, Theodoropoulos, Charalampos, Theodorou, Dimitrios, Triantafyllou, Tania, Garoufalia, Zoe, Hasemaki, Natasha, Kontos, Michalis, Kouraklis, Gregory, Kykalos, Stylianos, Liakakos, Theodore, Mpaili, Eustratia, Papalampros, Alexandros, Schizas, Dimitrios, Syllaios, Athanasios, Tampaki, Ekaterini Christina, Tsimpoukelis, Antonios, Antonopoulou, Maria Ioanna, Deskou, Eirini, Manatakis, Dimitrios K., Papageorgiou, Dimitrios, Zoulamoglou, Menelaos, Anthoulakis, Christos, Margaritis, Michalis, Nikoloudis, Nikolaos, Campo, Veronica, Ceballos, André, Flores, Mario-Andrés, Giron, Waleska, Ko, Donghyun, Martinez, Gabriel, Recinos, Gustavo, Rivera Lara, Verónica, Rueda, Nataly, Sanchez, Andres, Tejeda Garrido, Jorge Carlos Guillermo, Aguilera-Arevalo, Maria-Lorena, Alvarez Rivera, Alvaro Eduardo, Bamaca Ixcajoc, Elvis Benjamin, Barreda Zelaya, Lilian Elizabeth, Chacòn-Herrera, Patricia, Corea Ruiz, Ligia Margarita, Echeverria-Davila, Guillermo, Garcia, Mario, García, Danilo, Gutiérrez Mayen, Edgar Fernando, José, Noriega, Mazariegos, Nery, Méndez, Diego, Paniagua Espinoza, Michael, Baranyai, Zsolt, Bardos, David, Benke, Marton, Illes, Kristof, Kokas, Balint András, Szabó, Réka, Appukuttan, Akhila, Asok, Anjitha, D.K., Vijaykumar, Malik, Kapil, Ravishankaran, Praveen, Tapkire, Ritesh, Moorthy, Guru, Abraham, Joyner, Muthuvel, Ramesh, Alapatt, John, Kattepur, Abhay, Pareekutty, Nizamudheen, Garod, Mebanshanbor, Harris, Caleb, Wanniang, Cliff, Gupta, Ashish, Nehra, Deepak, Parshad, Sanjeev, Acharya, Rajgopal, Badwe, Rajendra, Bhandare, Manish, Jain, Urvashi, Kirti, Karishma, Nair, Nita, Shrikhande, Shailesh, Thakkar, Purvi, Anandan, Premkumar, C S, Archana, Holenarasipur Narasannaiah, Arun, Jagarlamudi, Tejaswi, Kumar Venkatappa, Sunil, M R, Rashmi, Manangi, Mallikarjuna, Raghavendra, Abhishek, Rao, K. Seshagiri, S, Vinay, Sajjan, Vinay, Shenoy, Aneesh, Shivashankar Chikkanayakanahalli, Santhosh, Tharanath, Kavya, V, Sushmita, Adidharma, Peter, Agarwal, Raksheeth, Amandito, Radhian, Anggita Gultom, Phebe, Arifin, Ghafur Rasyid, Billy, Matthew, Elfizri, Zatira, Fahira, Alessa, Felicia, Devi, Gunardi, Triana Hardianti, Johanna, Nadya, Nugrahadi, Nadia Rahmadiani, Panigoro, Sonar Soni, Rahmayanti, Siti, Sihotang, Retta Catherina, Brata, Santi Yuanita, Winoto, Hadi, Barati, Nastaran, Karami, Manoochehr, Khorshidi, Hamidreza, Naderifar, Homa, Abdulla, Mazin A., Coleman, Maggie, Doherty, Ronan J, Hannon, Rob, Murphy, Brenda, Stakelum, Aine, Winter, Des, Aljohmani, Lylas, Farnan, Richard, Seldon, Yeshey, Tan, Tanna, Varghese, Shriya, Alherz, Mohammad, Ather, Muaaz, Bajilan, Mohammad, Graziadei, Vivien, Pilkington, Isobel, Quidwai, Omar, Ridgway, Paul, Shiwani, Haaris, Tahir, Abd al-Rahman, Blunnie, Eimear, Burke, Daniel, Kennedy, Niall, Macdonagh, Kate, O'Neill, Maeve, Rooney, Siobhan, Falco, Giuseppe, Ferrari, Guglielmo, Mele, Simone, Nita, Gabriela Elisa, Ugoletti, Lara, Zizzo, Maurizio, Confalonieri, Gianmaria, Pesenti, Giovanni, Tagliabue, Fulvio, Baronio, Gianluca, Ongaro, Deborah, Pata, Giacomo, Compagnoni, Bruno, Salvadori, Renato, Taglietti, Lucio, D'Alessandro, Nicola, Di Lascio, Pierpaolo, Pascale, Giovanni, Bortolasi, Luca, Campagnaro, Tommaso, Carlini, Massimo, Lisi, Giorgio, Lombardi, Davide, Pedrazzani, Corrado, Spoletini, Domenico, Turri, Giulia, Violi, Paola, Altomare, Donato Francesco, Aquilino, Fabrizio, Musa, Nicola, Papagni, Vincenzo, Picciariello, Arcangelo, Vincenti, Leonardo, Andreotti, Dario, Occhionorelli, Savino, Tondo, Matteo, Basso, Stefano Maria Massimiliano., Cirelli, Riccardo, Maino, Marco Enrico Mario, Piozzi, Guglielmo Niccolò, Picone, Emanuele, Scaramuzzo, Rosa, Sinibaldi, Giovanni, Amendola, Alfonso, Anastasio, Lorenzo, Bucci, Luigi, Caruso, Emanuele, Castaldi, Antonio, Di Maso, Sara, Dinuzzi, Vincenza Paola, Esposito, Giovanni, Gaudiello, Maria, Giglio, Mariano Cesare, Greco, Paola Antonella, Luglio, Gaetano, Manfreda, Andrea, Marra, Ester, Mastella, Federica, Pagano, Gianluca, Peltrini, Roberto, Pepe, Vincenzo, Sacco, Michele, Sollazzo, Viviana, Spiezio, Giovanni, Cianchetti, Ettore, Menduni, Nunzia, Carvello, Michele Maria, Di Candido, Francesca, Spinelli, Antonino, Corsi, Fabio, Sorrentino, Luca, Marino, Fabio, Asti, Emanuele Luigi Giuseppe, Bonavina, Luigi, Rausa, Emanuele, Asta, Martina, Belli, Andrea, Bianco, Francesco, Cervone, Carmela, Delrio, Paolo, Falato, Armando, Fares Bucci, Andrea, Guarino, Rita, Pace, Ugo, Rega, Daniela, De Luca, Emilia, Gallo, Gaetano, Sammarco, Giuseppe, Sena, Giuseppe, Vescio, Giuseppina, Santandrea, Letizia, Ugolini, Giampaolo, Zattoni, Davide, Chetta, Nicola, Logrieco, Gaetano, Vanella, Serafino, Garulli, Gianluca, Zanini, Nicola, Bondurri, Andrea, Cammarata, Francesco, Colombo, Francesco, Foschi, Diego, Lamperti, Giulia Maria Beatrice, Maffioli, Anna, Sampietro, Gianluca Matteo, Yakushkina, Al'ona, Zaffaroni, Gloria, Ansaloni, Luca, Cicuttin, Enrico, Sibilla, Maria Grazia, Impellizzeri, Harmony, Inama, Marco, Moretto, Gianluigi, Mochet, Sylvie, Ponte, Elisa, Usai, Antonella, Mancini, Stefano, Sagnotta, Andrea, Solinas, Luigi, Bolzonaro, Elisa, Tamini, Nicolò, Curletti, Gianluca, Galleano, Raffaele, Malerba, Michele, Campanella, Sofia, Cocorullo, Gianfranco, Colli, Francesco, De Marco, Paolino, Falco, Nicolò, Fontana, Tommaso, Kamdem Mambou, Leonel jospin, La Brocca, Antonella, Licari, Leo, Randisi, Brenda, Rizzo, Giovanna, Rotolo, Giulia, Salamone, Giuseppe, Tutino, Roberta, Venturelli, Paolina, Malabarba, Stefano, Sgrò, Alessandro, Vella, Ivan, Cirillo, Bruno, Crocetti, Daniele, De Toma, Giorgio, Lapolla, Pierfrancesco, Mingoli, Andrea, Sapienza, Paolo, Belvedere, Angela, Bianchini, Stefania, Binetti, Margherita, Birindelli, Arianna, Tonini, Valeria, Podda, Mauro, Pulighe, Fabio, De Rosa, Michele, Bono, Lorenzo, Borghi, Felice, Geretto, Paolo, Giuffrida, Maria Carmela, Lauro, Corrado, Marano, Alessandra, Pellegrino, Luca, Salusso, Paola, Sasia, Diego, Campanelli, Michela, Realis Luc, Alberto, Trompetto, Mario, Cardia, Roberto, Cillara, Nicola, Giordano, Antonio Nicola, Costanzo, Antonio, Giovilli, Mario Alessandro, Turati, Luca, Canonico, Silvestro, Pellino, Gianluca, Sciaudone, Guido, Selvaggi, Francesco, Selvaggi, Lucio, Albsoul, Nader, AlBsoul, Ahmad, Alkhatib, Ala'a Aldeen, Alsallaq, Osama, Amarin, Justin Z., Ayoub, Rami, Bsisu, Isam, El Muhtaseb, M S, Jabaiti, Mohammad, Melhem, Jamal, Nour, Ibrahim, Qwaider, Yasmeen Z., Salameh, Mohammad Hasan, Suleihat, Ahmad, Suradi, Haya H., Alammarin, Mohammad, Aljaafreh, Almoutuz, Bani hani, Mohammad, Bani hani, Zeina, Bani Hani, Farah, Fahmawee, Toqa, Hamouri, Shadi, Katanani, Cyrine, Tawalbeh, Ra'fat, Tawalbeh, Tamara, Zawahrah, Hassan, Abou Chaar, Mohamad K., Abusalem, Lana, Al-Masri, Mahmoud, Al-Najjar, Hani, Barghuthi, Lutfi, Ahmed, Zahra, Maulana, Adnan, Ngotho, Omar, Kamau, Charbel, Stanley Mwenda, Aruyaru, Bosire, Fridah, Mwachiro, Elizabeth, Parker, Robert, Simel, Ian, Sylvester, Kimutai, Althini, Abdulmunem Ahmed Mustafa, Elbarouni, Sofian, Elbeshina, Aya Elseed, Gwea, Ahmed, Malek, Ans, Masoud Farag, Wedad Albashir, Abdalei, Abdulwahab, Abdel Malik, Abu Baker, Abo-khammash, Areej, Abuhlaiga, Ma'aly, Adnan, Nour, Albaggar, Marwa, Alfitory, Asma, Aljanfi, Asma, Almuzghi, Fakhruddin, Altumei, Zohoor, Alzabti, Fatima, Ashoushan, Hana, Assalhi, Mohamed, Azzubia, Joma, Bnhameida, Sondos, Delhen, Malik, Elshafei, Houssein, Elteir, Hana, Esbaga, Fatima, Gobbi, Abdel Aziz, Hamouda, Fatma, Hilan, Hamdan, Ismail, Rania, Jebran, Fieruz, Kasbour, Muataz, Maderi, Galia, Mohammad, Saja, Mohammed, Burooj, Murtadi, Habib, Mustafa, Hamassat, Rajab, Mohamed, Trenba, Sarah, Wafaa, Mariam, Al Sagheir, Eman, Almigheerbi, Alabas, Alzahaf, Ahmed, Bahroun, Sumayyah Ghayth, Ben Dallah, Najah, Elshaibani, Mahmoud, Eswaye, Haitem, Karar, Maha, Omar, Samah, Younes, Eman, Younes, Maha, Zreeg, Dafer, Abujamra, Saleh, Ashour, Firas, Elgammudi, Mala, Omar F. Aljadidi, Wesal, Saddouh, Enas, Sharif, Randa, Alabuzidi, Aya, Alwerfally, AbdulMawlay, Aribi, Sarra, Bibas, Fatma, Elfaituri, Taha, Elhajjaji, Yasmine, Khaled, Ala, Khalil, Wegdan, Layas, Tesneem, Soula, Enas, Tarek, Ahmed, Abu hallalah, Muad fathi khalleefah, Abujamra, Saleh, Ahmed, Hazem Abdelkarem, Alsharef, Tagwa, Ben Saoud, Abdulsalam Ali, El Gharmoul, Tasnim, Elhadi, Ahmed, Elrais, Safa, Shebani, Abdulhalim, Zarti, Heba, Zeiton, Asaid, Ambrazevicius, Marijus, Kaselis, Nerijus, Stakyte, Migle, Aliosin, Oleg, Cizauskaite, Agne, Dailidenas, Sarunas, Eismontas, Vitalijus, Kybransiene, Migle, Nutautiene, Vitalija, Samalavicius, Narimantas, Simcikas, Dainius, Slepavicius, Algirdas, Tamosiunas, Albinas, Ubartas, Nerijus, Zeromskas, Paulius, Bradulskis, Saulius, Dainius, Edvinas, Juocas, Juozas, Kubiliute, Egle, Kutkevicius, Juozas, Opolskis, Aurimas, Parseliunas, Audrius, Subocius, Andrejus, Venskutonis, Donatas, Virbickaite, Egle, Zuikyte, Diana, Bogusevicius, Algirdas, Buzaite, Kristina, Cepuliene, Daiva, Cesleviciene, Ieva, Cesna, Vaidotas, Gribauskaite, Jolanta, Ignatavicius, Povilas, Jokubauskas, Mantas, Liugailaite, Monika, Margelis, Ernest, Mazelyte, Ruta, Pankratjevaite, Lina, Pažusis, Matas, Rackeviciute, Agne, Saladyte, Justina, Škimelyte, Monika, Šlenfuktas, Vygintas, Sudeikyte, Monika, Tamelis, Algimantas, Vanagas, Tomas, Žumbakys, Žygimantas, Atkociunas, Aivaras, Dulskas, Audrius, Kuliavas, Justas, Birutis, Justas, Paškevicius, Sigitas, Šatkauskas, Mindaugas, Danys, Donatas, Jakubauskas, Matas, Jakubauskiene, Lina, Kryzauskas, Marius, Lipnickas, Vytautas, Makunaite, Gabija, Rasoaherinomenjanahary, Fanjandrainy, Rasolofonarivo, Herizo, Samison, Luc Hervé, Banda, Bitiel, Malemia, Precious, Msosa, Vanessa, Ahmad Izzuddin, Ahmad Imran, Das, Andre, Gan, Ying Yee, Shong Sheng, Tan, Siaw, Jia yng, Ab Rahim, Mohd Fadliyazid, Abang Jamari, Dyg Zahratul Hamrak, Che Husin, Nurfariza, Kamarulzaman, Muhd Yusairi, Lim, Yi Ping, Mohamed Kamil, Nil Amri, Mohd Hassan, Mohd Razeen, Mohd Sahid, Saidah, Mustafa, Johari, Ng, Elaine Hui Been, Wan Khazim, Wan Khamizar, Chang Ern, Ng, Lingeshan, P.G., Sulaiman, Syariz Ezuan, Ang, Sue Ean, Bin Mohamad Sithik, Muhammad Navid, Cheong, Yih Jeng, Deva Tata, Mahadevan, Jia Xian, Law, Kadravello, Aravinthan, Koh, I-Ern, Ng, Li-Yen, Ng We Yong, Yuki Julius, Palayan, Kandasami, Sam, Chi Xuan, Siow Jin, Phuah, Tan Ern Hwei, Jeremy, Tang, Yita, Ter, Alvin Zubin, Wong, Michael Pak-Kai, Zakaria, Andee Dzulkarnaen, Zakaria, Zaidi, Henry, Fitjerald, Kalaiselvan, Thyivya, Abd Karim, Muhammad Fairuz Shah, Abdul Aziz, Mohamed Rezal, Abdul Aziz, Nora, Khong, Tak Loon, Lau, Peng Choong, Lim, Hiong Chin, Roslani, April Camilla, Seak, Jonathan Chen Ken, Wong, Sui-Weng, Wong, Lai Fen, Yeen Chin, Leow, Anyanwu, Mercy Chinemerem, Borg, Elaine, Busuttil, Zachary, Calleja, Thomas, Chircop, Kurt Lee, Cutajar, Ruth, Dimech, Andrew Michael, Ellul, Sarah, Galea, Joseph, Gascon Perai, Kiara, Gatt, Ruth, Kelman, Lisa, Micallef, Elizabeth, Nwolu, Favour, Sammut, Kim, Thompson, Joanna, Warwicker, Sean, Zammit, Matthew, Cordera, Fernando, Cruz González, Efraín, Sánchez-García, Jorge, Barbosa Camacho, Francisco José, Barrera López, Francisco Javier, Zuloaga Fernandez del Valle, Carlos Jose, Acosta, Eric, González Espinoza, Iván Romarico, Moreno, Perla, Cortes-Flores, Ana Olivia, Fuentes Orozco, Clotilde, Gonzalez Ojeda, Alejandro, Corro Díaz González, Samantha, Martinez, Laura, Ramos-De la Medina, Antonio, Mosqueda Amador, Bonifacio, Novoa, Armando, Olazo Espejo, Dennet Arturo, Jimenez, Alejandro, Lopez Rosales, Federico, Vanoye, Elva Gabriela, Garcia Gonzalez, Luis Alberto, Miranda-Ackerman, Roberto Carlos, Solano-Genesta, Manuel, Alvarez-Cano, Alethia, Romero-Garza, Hector Hugo, Medina-Franco, Heriberto, Mejía-Fernández, Lorelí, Salgado-Nesme, Noel, Vergara-Fernandez, Omar, Gutiérrez-Mota, Guadalupe Montserrat, Hernandez Vera, Francisco Xavier, Llantada Lopez, Anabella, Morgan Villela, Gilberto, Ramirez Padilla, Felipe de Jesus, Tapia Marin, Walezka, Martínez Maldonado, Mónica, Sánchez Suárez, Ramses, Troche, José Manuel, Benyaiche, Chaymae, Outani, Oumaima, Amine, Souadka, Benkabbou, Amine, Majbar, Anass Mohammed, Mohsine, Raouf, Rafik, Ali, Oung, Thida, Tin, Moe Moe, Borowski, David W, Plarre, Philipp, Borowski, David W, Plarre, Philipp, Alberga, Anna, Sluiter, Nina, Tuynman, Jurriaan, Blok, Robin, Cömert, Didem, Hompes, Roel, Kalff, Marianne, Stellingwerf, Merel Elisabeth, Tanis, Pieter, van Berge Henegouwen, Mark, van Praag, Elise Maria, Wisselink, Daan, Gerhards, Michael, Lopes Cardozo, Josephine, Westerduin, Emma, de Jonge, Joske, van Geloven, Aaw, van Schilt, Kaz, den Boer, Frank, Stoots, Simone, Vlek, Stijn, Adams, Jamie, Al-Busaidi, Ibrahim S., Budd, Gabrielle, Choi, Seung il, Chu, Michael Jen Jie, Ganugapati, Anurag, McKinstry, Lucy, Pascoe, Rebecca, Richards, Simon, Rosser, Kenrick, Stevenson, Annie, White, Rebecca, Farik, Shebani, Kwun, Jin, Murad, Ahmed, Cowan, Sarah, Hall, Timothy, Hayton, Michael, Malam Sani, Laminou, Oumarou Garba, Souleymane, Adamou, Harissou, Amadou Magagi, Ibrahim, Habou, Oumarou, Aliyu, Halima, Daniyan, Muhammad, Sholadoye, Tunde T., Abdullahi, Lawal, Anyanwu, Lofty-John, Mohammad Mohammad, Aminu, Muhammad, Abubakar Bala, Sheshe, Abdurrahman Abba, Suleiman, Ibrahim, Adesina, Alaba, Awolowo, Ajibola, Onuoha, Clement, Salami, Omotayo, Taiwo, Ogechukwu, Taiwo, Agboola, Kache, Stephen, Makama, Jerry Godfrey, Sale, Danjuma, Abiola, Olajide, Ajao, Akinlabi, Ajiboye, Anthony, Etonyeaku, Amarachukwu, Olaogun, Julius, Adebanjo, Ademola, Adesanya, Opeoluwa, Afolayan, Michael Olatunji, Balogun, Olanrewaju, Makanjuola, Ayomide, Nwokocha, Samuel, Ojewola, Rufus Wale, Olajide, Thomas Olagboyega, Aderounmu, Adewale, Adesunkanmi, Abdul-Rashid, Adisa, Adewale, Agbakwuru, Augustine, Akeem Aderogba, Adeleke, Alatise, Olusegun Isaac, Arowolo, Olukayode, Lawal, Oladejo, Mohammed, Tajudeen, Ndegbu, Chinedu, Olasehinde, Olalekan, Wuraola, Funmilola, Akinkuolie, Akinbolaji, Etonyeaku, Amarachukwu, Mosanya, Arinzechukwu, Ayandipo, Omobolaji, Elemile, Peter, Lawal, Taiwo Akeem, Ali SANI, Samuel, Garba, Stephen, Hauwa SANI, Rebecca, Olori, Samson, Onyebuashi, Henry, Umoke, Ifeanyi, Adenuga, Adedire, Adeyeye, Ademola, Habeeb, Olufemi, Lawal, Bashir, Nasir, Abdulrasheed, Aahlin, Eirik Kjus, Kjønås, Didrik, Myrseth, Elisabeth, Abbasy, Jibran, Alvi, Abdul, Saleem, Omair, Afzal, Asma, Nazir, Anam, Farooq, Muhammad, Liaqat, Ayesha, Naqi, Syed Asghar, Raza, Ali, Sarfraz, Muzna, Sarwar, Muhammad, Banglani, Muntaha, Munir, Ambreen, Sehrish, Rahmat, Ayub, Bushra, Sayyed, Raza, Altaf, Amna, Ayub, Saima, Qureshi, Ahmad Uzair, Saeed, Komal, Syed, Bilal, Akbar, Sana Amir, Anwer, Abdul Wahid, Khan, Ruqayya Naheed, Khan, Amina Iqbal, Khattak, Shahid, Mohtasham, Sameen, Parvaiz, Muhammad Asad, Syed, Aamir Ali, Ansari, Abdul Basit, Shahzad, Noman, Khaliq, Tanwir, Rashid, Isbah, Waqar, Shahzad Hussain, Abu Al-saleem, Hasan, Abu Alqumboz, Amjad, Alqadi, Mohammad, Amro, Adham, Assa, Rawan, Awesat, Eman, Ayyad, Rawan, Hammad, Mohammed, Haymony, Ayat, Hijazi, Bassel, Hmeidat, Bara, Lahaseh, Rowaa, Qawasmi, Aseel, Rajabi, Alaa, Shehada, Mohammed, Shkokani, Sundus, Yaghi, Yasmine, Yaghi, Nadine, AlZohour, Mohammad, Farid, Mohammad, Habes, Yousef Mahmoud, Juba, Wesam, Nubani, Yanal, Rabee, Abdelrahman, Sa'deh, Mohammad, Abed, Saeed, Al basos, Iyad, Alswerki, Mohammad, Ashour, Dina, Awad, Israa, Diab, Samar, El Jamassi, Alaa, El-Kahlout, Sahar, Elhout, Somaya, Hajjaj, Ahmed N K, Hasanain, Doaa, Nabil hajjaj, Baraa, Obaid, Mohammed, Saikaly, Eman, Salhi, Ahmed, Al-Tammam, Hiba, Almasri, Murad, Baniowda, Muath, Beshtawi, Doha, Horoub, Ali, Misk, Rami, Mohammad, Bayan, Qasrawi, Rami, Sholi, Tasnim, Abu-Nimeh, Samar, Abu-srour, Abrar, Abukhalaf, Sadi A., Adawi, Samer, Alsalameh, Barah, Ayesh, Kholoud, Elqadi, Muawiyah, Hammouri, Ahmad, Karim Mustafa, Fatima, Marzouqa, Natalie, Melhem, Shatha, Miqdad, Dima, Mohamad, Balqees, Rawhi, Mhammed, Abu Ahammala, Ayman B., Abu Ataya, Ahmed, Abu Jayyab, Israa, Al-Shwaikh, Samar, Alagha, Othman, Alasttal, Mohammed, Awadallah, Haneen, Elblbessy, Mahmood, Fares, Jehad, Jarbou, Akram, Mahfouz, Ibtisam, Albahnasawi, Moath A., Abo mahadi, Asmaa', Abuelhatal, Hasan, Abuelqomboz, Ayham, Almoqayyad, Abdelrahman, Alwali, Abdallah, Balaawi, Reem, Hamouda, Mahmoud, Humeid, Mohammed, Jedyan, Abdullah, Mahmoud Abu hamam, Tasneem, Matar, Ghadeer, Salem, ALi, Samra, Tahani, Shaheen, Nureddin, Shihada, Karam, A.Nemer, Ayoob, Abu Al Amrain, Mahmoud, Abu Alamrain, Abdulwhhab, Abu Jamie, Najlaa, Abu-Rous, Mohammed R., Alfarra, Nada, AlTaweel, Mohammed, Alwhaidi, Noor, Hamed, Ramadan, Saqqa, Bader, Shaheen, Ahmad, Aljaber, Dana, Aljaberi, Loay, Alwaheidi, Malak, Jawaada, Assef, Khaldi, Hani, Qahoush, Rami, Qari, Jalil, Saadeh, Rana, Salim, Ahlam, Yacoub, Aseel, Abbas, Abbas, Abu shua'ib, Rana, Abu Zainah, Baraa, AbuSirrees, Mahmoud, Babaa, Basheer, Barhoush, Ola, Belal qadomi, Asef, Daraghmeh, Laith, Haji, Reema, Khatatbeh, Alaa, Khatib, Lana, Qarariah, Salsabeel, Quzmar, Yara, Safadi, Khalil, Salameh, Roqaya, Hassan, Mohammad, Herzallah, Shifaa, Massad, Loai, Nazzal, Ahmed, Nazzal, Ranin, Escobar, Dennis, Machain V, Gustavo Miguel, Rodriguez Gonzalez, Agustin, Chachaima Mar, Jorge Emerson, Chinchihualpa Paredes, Nathaly Olga, Cuba, Vicente, Lopez, Walter, Niquen Jimenez, Maria Milagros, Sanchez Bartra, Nestor Alberto, Sapallanay Ojeda, Olenka, Sequeiros, Diego, Toscano Pacheco, Andrea, Vergara, María, Abarca, Sol, Alcorta, Rodrigo, Borda-Luque, Giuliano, Eusebio Zegarra, Ivan Edward, Luján López, Claudia, Marrufo, Mirella, Mogrovejo, Cinthya, Nomura, Andrea, Rodríguez Angeles, Yamile, Vidal Meza, Maitza Rosario, Zavala, Gabriela, Castillo Arrascue, José Neiser, Hidrogo Cabrera, Jomara Caroline, Larrea vera, José Julio Mariano, Osorio, Miguel, Ylatoma Díaz, Edgar Alcides, Fontanilla, Mark Anthony, Fuentes, Joseph Roy, Salazar, Anna Leah, Dominguez, Genieve, Lopez, Marc Paul, Macalindong, Shiela, Onglao, Mark Augustine, Ramirez, Arjel, Sacdalan, Marie Dione, Tampo, Mayou Martin, Uy, Gemma Leonora, Mangahas, Jeremiah, Yabut, Kenneth, Cañete, Joannes Paul, Cansana, Bernalynn Eris, Castro, Ernes John, Lipana, Maria Kaiserin, Roxas, Manuel Francisco, Zara, Vlu Jean, Chrol, Maciej, Franczak, Paula, Orlowski, Michal, Budzynski, Piotr, Budzynski, Andrzej, Bury, Pawel, Czerwinska, Agata, Dworak, Jadwiga, Dziedzic, Jacek, Kisielewski, Michal, Kulawik, Jan, Lasek, Anna, Major, Piotr, Malczak, Piotr, Migaczewski, Marcin, Pedziwiatr, Michal, Pisarska, Magdalena, Radkowiak, Dorota, Rubinkiewicz, Mateusz, Rzepa, Anna, Skoczylas, Tomasz, Stanek, Maciej, Truszkiewicz, Katarzyna, Wierdak, Mateusz, Winiarski, Marek, Zarzycki, Piotr, Zub-Pokrowiecka, Anna, Kowalewski, Piotr, Roszkowski, Rafal, Waledziak, Maciej, Tomé, Miguel, Patrocinio, Sara, Guerreiro, Ines, Almeida, Filipe, de Sousa, Xavier, Monteiro, Nuno, Costa Santos, Maria Teresa, de Oliveira, Daniela, Lopes Serra, Marta, Morgado, Daniela, Neves, Christian, Oliveira, Ana Carolina, Pimentel, Alice, Silva, Sofia, Carvalho, Márcia, Carvalho, Lúcia, Magalhães, Joana, Matos, Leonor, Monteiro, Tânia, Ramos, Carlota, Santos, Vanessa, Barbosa, José, Costa-Maia, Jose, Devezas, Vítor, Fareleira, Ana, Fernandes, Cristina, Gonçalves, Diana, Mora, Henrique, Morais, Marina, Silva de Sousa, Fabiana, Catarino Santos, Sara, Logrado, Ana, Tojal, André, Amorim, Edgar, Cunha, Miguel F., Fazenda, Ana, Melo Neves, João Pedro, Sampaio da Nóvoa Gomes Miguel, Inês Isabel, Veiga, Diogo, Azevedo, José, Cardoso Louro, Hugo, Leite, Mariana, Azevedo, José, Bairos Menezes, Maria, Gama, Bárbara, Brito, Diana, Cruz Martins, Marta Cristina, Graça e Magalhães, André, Longras, Ana Catarina, Lourenço, Rita, Matos, Diana, Castro, Luis, Policarpo, Filipa, Romano, Joana, Leite, Mariana, Monteiro, Cristina, Pinto, Diogo, Duarte, Marina, Fortuna Martins, Sónia, Oliveira, Mariline, Galvão, Diogo, Martins, Lisandra, Silva, Anaisa, Taranu, Viorel, Vieira, Bárbara, Neves, Jessica, Oliveira, Simone, Ribeiro, Hugo, Cinza, Margarida, Felix, Rosa, Machado, Arnaldo, Oliveira, Joana, Patrício, Joana, Pedroso de Lima, Rita, Pereira, Mário, Rocha Melo, Miguel, Velez, Cristina, Abreu da Silva, Alberto, Claro, Mariana, Costa Santos, Daniel, Ferreira, Andreia, Capote, Hugo, Rosado, Daniela, Taré, Filipa, Nogueira, Oriana, Ângelo, Miguel, Baiao, José Miguel, Guimarães, Andreia, Marques, João, Nico Albano, Miguel, Silva, Marta, Valente da Costa, Ana, Vieira Caroço, Teresa, Almeida Braga, Sara, Capunge, Ines, Fragoso, Marta, Guimarães, João, Pinto, Bruno, Ribeiro, João, Angel, Miguel, Fialho, Guilherme, Guerrero, Monica, Campos Costa, Filipa, Cardoso, Diogo, Cardoso, Vasco, Alves, Magda, Estalagem, Inês, Louro, Tiago, Marques, Cláudia, Martelo, Rita, Morgado, Miguel, Canotilho, Rita, Correia, Ana Margarida, Martins, Pedro, Peyroteo, Mariana, Gomes, João, Monteiro, Rita, Romano, Manuela, Alves, Daniela Macedo, Peixoto, Rita, Quintela, Catarina, Jervis, Maria João, Melo, Débora, Pacheco, André, Paixão, Valter, Pedro, Vera, Pimenta, Joana, Pimenta de Castro, João, Rocha, Ana, Beuran, Mircea, Bratu, Matei Razvan, Ciubotaru, Cezar, Diaconescu, Bogdan, Hostiuc, Sorin, Negoi, Ionut, Stoica, Bogdan, NA, NA, Anokhin, Evgeny, Kuznetsov, Georgy, Oganezov, Giorgi, Paramzin, Fedor, Romanova, Ekaterina, Rutkovskii, Valeryan, Rutkovskii, Vasilii, Shushval, Mikhail, Zabiyaka, Mikhail, Dzhumabaev, Khasan, Ivanov, Valerii, Mamedli, Zaman, Achkasov, Sergey, Balkarov, Artem, Nabiev, Elnur, Nagudov, Marat, Rybakov, Evgeny, Saifutdinova, Karina, Sushkov, Oleg, Vardanyan, Armen, Costas-Chavarri, Ainhoa, Joseph, Lule, Ndayishimiye, Isaac, Allen Ingabire, JC, Faustin, Ntirenganya, Mutabazi, Alphonse Zeta, Mvukiyehe, Jean Paul, Nsengimana, Vizir J.P., Uwakunda, Carine, Abbas, Mohammad Monir, Akeel, Nouf, Aljiffry, Murad, Awaji, Kholoud, Farsi, Ali, Jamjoum, Ghader, Khoja, Ahmad, Maghrabi, Ashraf, Malibary, Nadim, Nassif, Mohammed, Saleem, Abdulaziz, Sultan, Abdullah, Tashkandi, Wail, Tashkandi, Hanaa, Trabulsi, Nora, Ba, Mouhamadou Bachir, Diallo, Adja Coumba, Ndong, Abdourahmane, Cuk, Vladica, Jankovic, Uroš, Juloski, Jovan, Koh, Sharon Zhiling, Koh, Frederick, Lee, Kuok Chung, Lee, Kai Yin, Lee, Sean, Leong, Wei Qi, Lieske, Bettina, Lui, Su Ann, Prakash, Prajwala, Grosek, Jan, Norcic, Gregor, Tomazic, Ales, Fitchat, Nicolas, Jaich, Robert, Wineberg, Devorah, Koto, Modise Zacharia, Baiocchi, Daniella, Clarke, Damian, Steenkamp, Christina Johanna, Van Straten, Stephanie, Bannister, Sharon, Boutall, Adam, Chinnery, Galya, Coccia, Anna, Dell, Angela, Karjiker, Parveen, Kloppers, Christo, Loxton, Nicholas, Mabogoane, Tumi, Malherbe, Francois, Panieri, Eugenio, Rayamajhi, Shreya, Spence, Richard, van Wyngaard, Tirsa, Warden, Claire, Madiba, T E, Moodley, Yoshan, Pillay, Nivashen, Brooks, Savannah, Kruger, Charlise, Van Der Merwe, Lisa Hannah, Gool, Ferhana, Kariem, Maahir, Bougard, Heather, Chu, Kathryn, Kariem, Nazmie, 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Nepogodiev, Dmitri, Pipe, Michelle, Bhatti, Muhammad Iqbal, Rabie, Mohamed, Boyle, Connor, Hamilton, David, Mihuna, Aishath, Ng, James Chean Khun, Nicholson, Gary, Oliwa, Agata, Pearson, Robert, Rose, Anna, Yong, Shun Qi, Boereboom, Catherine, Hanna, Michael, Walter, Catherine, Greensmith, Thomas Samuel, Mitchell, Rachel, Monaghan, Eimear, Crawford, James, Moug, Susan, Blackwell, James, Boyd-Carson, Hannah, Herrod, Philip, Al-Allaf, Omar, Beattie, Miriam, Bullock, Cameron, Burman, Shivang, Clark, Gemma, Flamey, Nicolas, Flannery, Oliver, Harding, Alexander, Kodiatt, Ben, Lawday, Samuel, Mahapatra, Shivani, Mukundu Nagesh, Navin, Ng, Michael, Rye, Dupinderjit, Yoong, Andrel, Clark, Laura, Deans, Chris, Edirisooriya, Monisha, Fairfield, Cameron J, Harrison, Ewen M, Carrington, Emma Victoria, Wong, Tsz Lun Ernest, Yusuf, Baasil, Chamberlain, Carla, Duke, Kathryn, Kmiotek, Elizabeth, Botes, Azel, Condie, Natalie, Schrire, Timothy, Shah, Reena, Thomas-Jones, Iolo, Yates, Charlotte, Anthony, Natasha, Matthews, Edward, Sahnan, Kapil, Tankel, James, Tucker, Sally, Winter Beatty, Jasmine, Ziprin, Paul, Duggan, William, Kantartzi, Anastasia, Sridhar, Shruthi, Khaw, Rachel Alys, Srivastava, Prakhar, Underwood, Charlotte, Alves do Canto Brum, Homero, Chopra, Sharat, Davis, Laura, Hughes, Rebecca, Tulley, Joshua, Alberts, Justin, Athisayaraj, Thomas, Olugbemi, Mojolaoluwa, Ahmad, Kasim, Chan, Claudia, Chapman, Gavin, Fleming, Hannah, Fox, Benjamin, Grewar, Julia, Hulse, Kate, Rutherford, Duncan, Sinead, Mackay, Smith, Scott, Speake, Doug, Vaughan-Shaw, Peter G, Christodoulides, Natasha, Kudhail, Simrit, Welch, Matthew, Husaini, Syed Muhibullah, Lambracos, Simon, Anyanwu, Chikamuche, Suresh, Rishi, Thomas, Jimmy Scott, Gleeson, Elizabeth, Platoff, Rebecca, Saif, Areeba, Enumah, Zachary, Etchill, Eric, Gabre-Kidan, Alodia, Bernstein, Mitchell, Carrano, Francesco Maria, Connors, Joseph, Lynn, Patricio, Melis, Marcovalerio, Newman, Elliot, Foster, Deshka S, Perrone, Kenneth, Titan, Ashley, Weiser, Thomas G, Ahmad, Sarwat, Bafford, Andrea Chao M.D., Dal Molin, Marco, Hanna, Nader, Zafar, Syed Nabeel, Hemmila, Mark, Napolitano, Lena, Wong, Jane J, Chandler, Julia, Wood, Lauren, Wren, Sherry, Ottesen, Taylor, You, Lucia, Yu, Kristin, Arciénega Yañez, María del pilar, Ferreira Fernandes, Martin, González, Daniel, Cubas, Santiago, González, María Catalina, Zubiaurre, Vanessa, Demolin, Rodrigo, Giroff, Nicolas, Sciuto, Pablo, Campos, Maite, Rodríguez Cantera, Gabriela, Wagner, Gabriela, Deepika, Garg, Maimbo, Mayaba, Simuchimba, Elliot, Bulaya, Anadi, Chibuye, Chali, Chirengendure, Bright, Kabale, Mary-Rose, Kabongo, Kizito, Linyama, David, Munthali, James, Mweso, Oliver, Pikiti, Francis, Otieno, James, Chan, Erick, Lai, Log Tung, Blackman, Brighid, Richards, Sophie, Subramaniam, Suren, Karim, Rafid, Kok, Nathan, Lee, Yanni Dion, Ali, Shabina, Sinha, Aanjaneya, Corrigan, Robert, Barnes, Nicole, Wong, Florence, Dennis, Grace, Jedamzik, Julia, Phillips, Emil, Piette, Wivine, Van hentenryck, Marie, Koco, Houenoukpo, Lawani, Souliath, Kassa, Mamo Woldu, Santos Bezerra, Tainá, Gribnev, Petar, Dimitrov, Dobromir, Krastev, Panche, Oum, Sovannarith, Bonghaseh, Divine Tim, Al Farsi, Maryam, Alsharqawi, Nourah, Agarwal, Arnav, Acevedo, Veronica, Castillo Barbosa, Andrea Carolina, Giron, Felipe, Leon Rodriguez, Jimmy Paul, Kucan, Darko, Rosko, Damir, Barsic, Neven, Župan, Domagoj, Hegazi, Amgad, Truncíková, Vendula, Fryba, Vladimir, Mohamed, Mostafa, Sultan, Ahmed, Nagi, Ahmed, Rashad Temerik, Abdallah, Elshawy, Mohamed Elemam, Mahmoud, Moustafa Ibrahim, Omar, Shrouk, Anwar, Mohamed, Rageh, Tarek, Elmokadem, Aya, Gaballa, Khaled, Teppo, Sandra, Turunen, Antti, Pengermä, Pasi, Ballouhey, Quentin, Bergeat, Damien, Weyl, Ariane, Hain, Elisabeth, Gyedu, Adam, Yenli, Edwin, Osei-Poku, Dorcas, Rompou, Vaia-Aliki, Zoikas, Athanasios, Gaitanidis, Apostolos, Koukis, Georgios, Perivoliotis, Konstantinos, Tavlas, Panagiotis, Galanos-Demiris, Konstantinos, Zografos, George, Karavokyros, Ioannis, Xanthopoulou, Georgia, Iordanidou, Eirini, Ayau, Fernanda, Garcia, Allan, Damján, Pekli, Wason, Deepender, B L, Ashika, Rangganata, Ervandy, Kamath, Prerna, O'Connor, Donal B, Pinto, Margherita, Perrone, Fabrizio, Tropeano, Francesca Paola, Troilo, Francesca, Bossi, Daniela, Scala, Dario, Pulitanò, Lucrezia, Carella, Marcella, Pietrabissa, Andrea, Gori, Alice, Giraudo, Giorgio, De Simone, Veronica, Russo, Alfio Alessandro, Braccio, Bartolomeo, Al-Taher, Raed, Athamneh, Sarah, Parker, Andrea, Sawiee, Adnan, Kattia, Amina, Salem, Malik, Tababa, Osama, Shaeeb, Zuhour, Syminas, Vilius, Jurgaitis, Jonas, Damuleviciene, Gyte, Svagzdys, Saulius, Poskus, Tomas, Razafimanjato, Narindra Njarasoa Mihaja, Chieng Loo, Ling, Tiong, Ing Ching, Wan Muhmad, Wan Farahiyah, Vijeyan, Harinthiran, Li Ying, Teoh, Grech, Gabriella, Arrangoiz, Rodrigo, Jimenez Ley, Vania Brickelia, Arizpe, Daniel, Jimenez Ley, Vania Brickelia, Lagunes Lara, Elizabeth, Castro López, Elizabeth Victoria, Eaazim, Jose, Gordinou de Gouberville, Marije, Bastiaenen, Vivian, Rottier, Simone, Nahab, Fouad, Ji, Maria Yeonhee, Seyoji, Mohammed, Nwachukwu, Callistus, Emeghara, Okechukwu, Muhammed, Sayyid Egbunu, Idowu, Ayodeji, Sowemimo, Olamiposi, Ogundoyin, Olakayode, Akande, Oluwatosin, Lott, Alexander, Nadeem, Maliha, Laghari, Ahsan Ali, Loya, Asif, Mushtaq, Hassan, Abdullah, Muhammad Tariq, Abuhilal, Baseel, Atawneh, Mohammad, Hamdan, Hamdan, Alhabil, Belal, Srour, Abedelrahman, Mousa, Ibrahim, Da Silva Medina, Luis, Sacdalan, Marie Dione, Lapitan, Marie Carmela, Sacdalan, Marie Dione, Sacdalan, Marie Dione, Bartosiak, Katarzyna, Ferreira, Pedro, Francisco, Vítor, Lemos, Ricardo, Frutuoso, Luísa, Fernandes, Sara, Fonseca, Telma, Pereira, Jorge, Rachadell, Juan, Torre, Ana, Madeira Martins, Filipe, Carvalho, Ana Cristina, Rodrigues Ferreira, Joana, Ribeiro da Silva, Bruno, Devesa, Helena, Vieira, Ana, Mónica, Inês, Amaro, Margarida, Sousa, Diogo, Reia, Marta, Louro, João, Martins, Ana, Dominguez, Joaquina, Santos, Inês, Freitas Oliveira, Nuno Miguel, Pereira, José Carlos, Silva-Vaz, Pedro, Freire, Ligia, Escrevente, Ricardo, Negoita, Valentina Madalina, Shakhmatov, Dmitry, Nezerwa, Yves, Radulovic, Radosav, Moore, Rachel, Obery, Gareth, Viljoen, Francois, Mendes, Tome, Suarez, Antonio, Moncada, Enrique, Fernandez-Hevia, Maria, Curtis Martínez, Carolina, Gil Garcia, Julia Maria, González Zunzarren, Mariana, Idris, Tarig, Eklöv, Karolina, Grahn, Oskar, Amin, Leila, Blomqvist, Malin, Ajani, Costanza, Kraus, Rebecca, Seeger, Nico, Willemin, Melissa, Rayya, Fadi, Ayash, Mohammad, Msouti, Raneem, Kannas, Israa, Abazid, Eias, Esper, Asil, Slim, Skander, Kavcar, Akil Serdar, Aytac, Erman, Dural, Ahmet Cem, Ilker, Ayse, Eray, Ismail Cem, Kurnaz, Eray, Altiner, Saygin, Tepe, Mustafa Deniz, Sahin, Can, Savli, Evrim, Innocent, Aryon, Babirye, Lilian, Diachenko, Andrii, Hordoskiy, Vladislav, Curry, Heather, Chau, Charlene Yat Che, Robertson, Harry, Mahmoud, Arin, Lennon, 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- Abstract
80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality.
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- 2021
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5. DNA damage assessment of human breast and lung carcinoma cells irradiated with protons and carbon ions
- Author
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Ristic-Fira, Aleksandra M., Keta, Otilija D., Petković, Vladana D., Cammarata, Francesco P., Petringa, Giada, Cirrone, Pablo G.A., Cuttone, Giacomo, Incerti, Sebastien, and Petrović, Ivan M.
- Abstract
Differences in biological response of breast and lung cancer cells to 62 MeV/u therapeutic protons and carbon ions are investigated on MCF-7 and HTB177 cells. Hydroxyl radical scavenger, dimethyl sulfoxide (DMSO) is applied to reduce indirect effects of irradiation, while serum deprivation provided uniformity of cell population. Survival, immunocytochemical, and cell-cycle analysis, changes in protein expression involved in repair and apoptosis are followed. Radiobiological parameters, Bax/Bcl-2 ratio, and increased subG1 fraction show that carbon ions are more efficient in cellular killing than protons. No significant difference in the number of γH2AX foci are found between protons and carbon ions. According to SF2 values, MCF-7 cells are more radioresistant to both ion species compared to HTB177 cells. Cell-cycle analysis and expression of relevant protein markers further confirm somewhat higher radiosensitivity of HTB177 cells compared to MCF-7. DMSO leads to the rise of cell survival and decreases the number of γH2AX foci. Even though there are no significant changes in the number of γH2AX foci after used irradiation types, lesions induced by carbon ions are probably more complex than those produced by protons. DMSO minimizes indirect DNA damage to achieve experimental conditions needed for comparisons of obtained results with numerical simulations.
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- 2020
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6. Proton-irradiated breast cells: molecular points of view.
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Bravatà, Valentina, Cammarata, Francesco P, Minafra, Luigi, Pisciotta, Pietro, Scazzone, Concetta, Manti, Lorenzo, Savoca, Gaetano, Petringa, Giada, Cirrone, Giuseppe A P, Cuttone, Giacomo, Gilardi, Maria C, Forte, Giusi I, and Russo, Giorgio
- Abstract
Breast cancer (BC) is the most common cancer in women, highly heterogeneous at both the clinical and molecular level. Radiation therapy (RT) represents an efficient modality to treat localized tumor in BC care, although the choice of a unique treatment plan for all BC patients, including RT, may not be the best option. Technological advances in RT are evolving with the use of charged particle beams (i.e. protons) which, due to a more localized delivery of the radiation dose, reduce the dose administered to the heart compared with conventional RT. However, few data regarding proton-induced molecular changes are currently available. The aim of this study was to investigate and describe the production of immunological molecules and gene expression profiles induced by proton irradiation. We performed Luminex assay and cDNA microarray analyses to study the biological processes activated following irradiation with proton beams, both in the non-tumorigenic MCF10A cell line and in two tumorigenic BC cell lines, MCF7 and MDA-MB-231. The immunological signatures were dose dependent in MCF10A and MCF7 cell lines, whereas MDA-MB-231 cells show a strong pro-inflammatory profile regardless of the dose delivered. Clonogenic assay revealed different surviving fractions according to the breast cell lines analyzed. We found the involvement of genes related to cell response to proton irradiation and reported specific cell line- and dose-dependent gene signatures, able to drive cell fate after radiation exposure. Our data could represent a useful tool to better understand the molecular mechanisms elicited by proton irradiation and to predict treatment outcome.
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- 2019
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7. Delayed luminescence in a multiparameter approach to evaluation and reduction of radiobiological risks
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Amelink, Arjen, Vitkin, I. Alex, Grasso, Rosaria, Cammarata, Francesco Paolo, Minafra, Luigi, Marchese, Valentina, Russo, Giorgio, Manti, Lorenzo, Musumeci, Francesco, and Scordino, Agata
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- 2017
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8. Liver resection of hepatocellular carcinoma in HIV-HCV co-infected patients: a retrospective case series
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Cammarata, Francesco, Benuzzi, Laura, Crespi, Michele, Troci, Albert, Pennacchi, Luca, Schiavini, Monica, and Foschi, Diego
- Abstract
Introduction: Despite the effectiveness of new therapies and awareness campaigns, the number of seropositive patients is increasing every year. Recently, other causes of death, not directly related to HIV, have emerged, such as chronic liver disease. The risk of hepatocellular carcinoma (HCC) is seven times greater in HIV patients than in noninfected patients, and it is especially attributable to HCV infection. The aim of our study was to evaluate clinical outcomes of HCC in HIV-HCV co-infected patients after liver resection (LR). Materials and methods: The current study was conducted on a prospective database and reviewed retrospectively. All consecutive patients with HCC treated by LR from January 2013 to March 2019 at the Luigi Sacco University Hospital in Milan were enrolled. We included patients older than 18 years of age with HCV-related HCC, and in this set of patients, we identified two groups based on the presence of HIV infection. Results: We identified 16 patients with HCV infection and precisely five with HIV-HCV co-infection and eleven with HCV infection alone. All HIV patients were male against 72.7% in the non-HIV group (p= 0.509). All patients had optimal HIV virologic control and a normal CD4 T-cell count. The mean diagnosis-to-treatment interval was statistically different between the two groups (HIV versus non-HIV: 1.2 ± 0.55 months versus 2.39 ± 1.09 months, p= 0.039). Conclusions: With a multidisciplinary approach and intensive support, LR can be a safe and efficacious procedure in HIV-HCV patients. For these reasons, we should not exclude potential patients merely on the basis of their HIV seropositivity.
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- 2022
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9. Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation.
- Author
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Césaire, Mathieu, Ghosh, Utpal, Austry, Jean-Baptiste, Muller, Etienne, Cammarata, Francesco Paolo, Guillamin, Marilyne, Caruso, Massimo, Castéra, Laurent, Petringa, Giada, Cirrone, Giuseppe Antonio Pablo, and Chevalier, François
- Abstract
Chondrosarcoma is a malignant tumor that arises from cartilaginous tissue and is radioresistant and chemoresistant to conventional treatments. The preferred treatment consists of surgical resection, which might cause severe disabilities for the patient; in addition, this procedure might be impossible for inoperable locations, such as the skull base. Carbon ion irradiation (hadron therapy) has been proposed as an alternative treatment, primarily due to its greater biological effectiveness and improved ballistic properties compared with conventional radiotherapy with X-rays. The goal of this study was to characterize the genetic mutations of a grade III chondrosarcoma cell line (CH2879) and examine the cellular responses to conventional radiotherapy (X-rays) and hadron therapy (proton and carbon ions) in the presence of the PARP inhibitor Olaparib. To better understand PARP inhibition, we first analyzed the formation of poly-ADP ribose chains by western blot; we observed an increase in its signal after irradiation, which disappeared on addition of the PARP inhibitor. PARPi enhanced ratio of approximately 1.3, 1.8, and 1.5 following irradiation of cells with X-rays, protons, and C-ions, respectively, as detected by clonogenic assay. The decrease in cell survival was confirmed by proliferation assay. The radiosensitivity of CH2879 cells was associated with mutations in homologous recombination repair genes, such as RAD50, SMARCA2 and NBN. This study demonstrates the capacity of the PARP inhibitor Olaparib to radiosensitize mutated chondrosarcoma cells to conventional photon irradiation, proton and carbon ion irradiation. Image, graphical abstract [ABSTRACT FROM AUTHOR]
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- 2019
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10. Abstract ID: 35 Monte Carlo dosimetric study for preclinical small animal hadrontherapy using Geant4 toolkit.
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Pisciotta, Pietro, Russo, Giorgio, Pablo Cirrone, Giuseppe Antonio, Romano, Francesco, Cammarata, Francesco Paolo, Petringa, Giada, Forte, Giusi Irma, Lamia, Debora, Acquaviva, Rosaria, Gilardi, Maria Carla, and Cuttone, Giacomo
- Abstract
Preclinical studies represent an important step to study molecular mechanism induced inside cells in response to ionizing radiations. The scope was the study of the preliminary steps to perform particle treatment of cancer cells inoculated in small animals and to realize a preclinical hadrontherapy facility. At this scope, a well-defined dosimetric protocol was developed to perform the steps needed in order to perform a precise proton irradiation in small animals and achieve highly conformal dose. Homemade positioning system for small animals was developed at INFN-LNS(Italy) and an accurate Monte Carlo simulation was developed. The application, developed using Geant4.10.03 version, includes in the current version of the advanced example “Hadrontherapy” [1] the main functionalities of the “DICOM” extended example [2] . In this way, this application simulates the CATANA beam line geometry and includes the capability to implement DICOM-TC images as target. The application will be used to carry out dosimetric and LET studies [3] using the real target composition. This application was validated comparing its results with experimental measurements. A validation test, using solid water slabs phantom, and a treatment simulation, irradiating a PMMA phantom that simulate subcutaneous tumours, were executed at CATANA facility using in both cases EBT3-Gafchromic films as dose detector. The dosimetric results were compared with the simulation ones using Kolmogorov and gamma index test. Experimental data are in good agreement with the simulation ones. The phantom targets were included in the simulation environment using DICOM-TC images. Dosimetric measurements were useful to determine the efficiency of the developed Geant4 application and to demonstrate that it is a valid instrument to study the dose distribution in different types of phantoms with different kinds of geometry. This work has been carried-out in the perspective of realization of a preclinical hadrontherapy facility at INFN-LNS in order to implement interesting future in vivo studies using small animals. [ABSTRACT FROM AUTHOR]
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- 2017
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11. Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility
- Author
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Minafra, Luigi, Bravat?, Valentina, Saporito, Michele, Cammarata, Francesco, Forte, Giusi, Caldarella, Salvatore, D?Arienzo, Michele, Gilardi, Maria, Messa, Cristina, and Boniforti, Filippo
- Abstract
Osteoarthritis (OA) is considered to be a multifactorial and polygenic disease and diagnosis is mainly clinical and radiological. Correlation between radiographic data and clinical status has been reported. However, very few studies, especially in Caucasian people, describe the association between the Kellgren and Lawrence OA grading scale (KL) and genetic alterations to better understand OA etiopathogenesis and susceptibility. In order to update the knee OA grading, in this study we assessed the associations between KL grade, clinical features such as American Knee Society Score (AKSS), age, and polymorphisms in the principal osteoarthritis susceptibility (OS) genes in Sicilian individuals.
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- 2014
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