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8 results on '"Calle, Andrés"'

1. Association of muscle disorders in late postmenopausal women according to the type of experienced menopause

Author

Vallejo, María S., Blümel, Juan E., Chedraui, Peter, Tserotas, Konstantinos, Salinas, Carlos, Rodrigues, Marcio A., Rodríguez, Doris A., Rey, Claudia, Ojeda, Eliana, Ñañez, Mónica, Monterrosa-Castro, Álvaro, Gómez-Tabares, Gustavo, Espinoza, María T., Escalante, Carlos, Elizalde, Alejandra, Dextre, Maribel, Calle, Andrés, and Aedo, Sócrates

Abstract

Women experiencing surgical premature menopause have a higher likelihood of developing muscle disorders. This underscores the potential significance of hormonal levels in influencing musculoskeletal health during postmenopause.

Published
2024
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2. Post-COVID-19 syndrome in a sample of climacteric women living in Latin America

Author

Blümel, Juan Enrique, Vallejo, María Soledad, Bencosme, Ascanio, Calle, Andrés, Dextre, Maribel, Díaz, Karen, López, Marcela, Miranda, Carlos, Ñañez, Mónica, Ojeda, Eliana, Rey, Claudia, Rodrigues, Marcio Alexandre Hipólito, Salinas, Carlos, Tserotas, Konstantinos, Aedo, Sócrates, and Pérez-López, Faustino R.

Abstract

A series of physical and psychological symptoms that impair mental health and quality of life can affect a significant percentage of middle-aged and postmenopausal women who have had COVID-19. Current evidence supports implementing interventions to increase resilience along with appropriate clinical management of sleep-related and climacteric complaints.

Published
2023
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3. CRISPR/Cas9-modified hematopoietic stem cells—present and future perspectives for stem cell transplantation

Author

Daniel-Moreno, Alberto, Lamsfus-Calle, Andrés, Raju, Janani, Antony, Justin S., Handgretinger, Rupert, and Mezger, Markus

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is a standard therapeutic intervention for hematological malignancies and several monogenic diseases. However, this approach has limitations related to lack of a suitable donor, graft-versus-host disease and infectious complications due to immune suppression. On the contrary, autologous HSCT diminishes the negative effects of allogeneic HSCT. Despite the good efficacy, earlier gene therapy trials with autologous HSCs and viral vectors have raised serious safety concerns. However, the CRISPR/Cas9-edited autologous HSCs have been proposed to be an alternative option with a high safety profile. In this review, we summarized the possibility of CRISPR/Cas9-mediated autologous HSCT as a potential treatment option for various diseases supported by preclinical gene-editing studies. Furthermore, we discussed future clinical perspectives and possible clinical grade improvements of CRISPR/cas9-mediated autologous HSCT.

Published
2019
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4. Generation of a heterozygous and a homozygous CSF1R knockout line from iPSC using CRISPR/Cas9.

Author

Schmitz, Anne S., Korneck, Milena, Raju, Janani, Lamsfus-Calle, Andrés, Daniel-Moreno, Alberto, Antony, Justin S., Mezger, Markus, Schöls, Ludger, Hauser, Stefan, and Hayer, Stefanie N.

Abstract

Mutations in Colony-stimulating factor 1 receptor (CSF1R) lead to CSF1R-related leukoencephalopathy, also known as Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rapidly progressing neurodegenerative disease with severe cognitive and motor impairment. In this study, a homozygous and a heterozygous CSF1R knockout induced pluripotent stem cell (iPSC) line were generated by CRISPR/Cas9-based gene editing. These in vitro models will provide a helpful tool for investigating the still largely unknown pathophysiology of CSF1R-related leukoencephalopathy. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Association between anxiety and severe quality-of-life impairment in postmenopausal women: analysis of a multicenter Latin American cross-sectional study

Author

Núñez-Pizarro, Jorge L., González-Luna, Alejandro, Mezones-Holguín, Edward, Blümel, Juan E., Barón, Germán, Bencosme, Ascanio, Benítez, Zully, Bravo, Luz M., Calle, Andrés, Flores, Daniel, Espinoza, María T., Gómez, Gustavo, Hernández-Bueno, José A., Martino, Mabel, Lima, Selva, Monterrosa, Alvaro, Mostajo, Desiree, Ojeda, Eliana, Onatra, William, Sánchez, Hugo, Tserotas, Konstantinos, Vallejo, María S., Witis, Silvina, Zúñiga, María C., and Chedraui, Peter

Published
2017
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6. Sedentary lifestyle in middle-aged women is associated with severe menopausal symptoms and obesity

Author

Blümel, Juan E., Fica, Juan, Chedraui, Peter, Mezones-Holguín, Edward, Zuñiga, María C., Witis, Silvina, Vallejo, María S., Tserotas, Konstantinos, Sánchez, Hugo, Onatra, William, Ojeda, Eliana, Mostajo, Desireé, Monterrosa, Alvaro, Lima, Selva, Martino, Mabel, Hernández-Bueno, José A., Gómez, Gustavo, Espinoza, María T., Flores, Daniel, Calle, Andrés, Bravo, Luz M., Benítez, Zully, Bencosme, Ascanio, Barón, Germán, and Aedo, Sócrates

Published
2016
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7. Age at menopause in Latin America

Author

Blümel, Juan E., Chedraui, Peter, Calle, Andrés, Bocanera, Roberto, Depiano, Eduardo, Figueroa-Casas, Pedro, Gonzalez, Carlos, Martino, Mabel, Royer, Monique, Zuñiga, Cristina, Dulon, Alfredo, Espinoza, María T., Futchner, Carlos, Mostajo, Desireé, Soto, Edwin, Marco, Aurélio A., Aravena, Hernán, Busquets, Maritza, Campodonico, Italo, Germain, Alfredo, Alba, Alcira, Baron, Germán, Gomez, Gustavo, Monterrosa, Alvaro, Onatra, Williams, Broutin, Gerardo, Manzano, Blanca, Gabriela, Ayala, Hidalgo, Luis, Leon, Patricia, Orbea, Marcos, Sanchez, Hugo, Vallejo, Soledad, Vallecillo, Gaspar, Hernandez-Bueno, Jose A., Motta, Eduardo, Andrade, Rafael, Tserotas, Konstantinos, Gonzalez, Carlos M., Benitez, Zully, Calle, Elena, Danckers, Luis, Del Castillo, Angélica, Izaguirre, Humberto, Ojeda, Eliana, Rojas, Juan, Bencosme, Ascanio, and Lima, Selva

Abstract

To assess the age at menopause (AM) in Latin America urban areas.

Published
2006
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8. Hematopoietic stem cell gene therapy: The optimal use of lentivirus and gene editing approaches.

Author

Lamsfus-Calle, Andrés, Daniel-Moreno, Alberto, Ureña-Bailén, Guillermo, Raju, Janani, Antony, Justin S., Handgretinger, Rupert, and Mezger, Markus

Abstract

Due to pioneering in vitro investigations on gene modification , gene engineering platforms have incredibly improved to a safer and more powerful tool for the treatment of multiple blood and immune disorders. Likewise, several clinical trials have been initiated combining autologous hematopoietic stem cell transplantation (auto-HSCT) with gene therapy (GT) tools. As several GT modalities such as lentivirus and gene editing tools have a long developmental path ahead to diminish its negative side effects, it is hard to decide which modality is optimal for treating a specific disease. Gene transfer by lentiviruses is the platform of choice for loss-of-mutation diseases, whereas gene correction/addition or gene disruption by gene editing tools, mainly CRISPR/Cas9, is likely to be more efficient in diseases where tight regulation is needed. Therefore, in this review, we compiled pertinent information about lentiviral gene transfer and CRISPR/Cas9 gene editing, their evolution to a safer platform for HSCT, and their applications on other types of gene disorders based on the etiology of the disease and cell fitness. [ABSTRACT FROM AUTHOR]

Published
2020
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