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1. Autoimmune manifestations in aged mice arise from early-life immune dysregulation

Author

Mahmoud, Tamer I., Wang, Jingya, Karnell, Jodi L., Wang, Qiming, Wang, Shu, Naiman, Brian, Gross, Phillip, Brohawn, Philip Z., Morehouse, Chris, Aoyama, Jordan, Wasserfall, Clive, Carter, Laura, Atkinson, Mark A., Serreze, David V., Braley-Mullen, Helen, Mustelin, Tomas, Kolbeck, Roland, Herbst, Ronald, and Ettinger, Rachel

Abstract

Autoimmune manifestations are driven by peripheral immune dysregulation in early life and are prevented by prophylactic targeting of the CD40/CD40L pathway.

Published
2016
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