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1. Recombinant Human Deoxyribonuclease in Infants With Respiratory Syncytial Virus Bronchiolitis

Author

Boogaard, Ruben, Hulsmann, Anthon R., van Veen, Leoniek, Vaessen-Verberne, Anja A.P.H., Yap, Yen Ni, Sprij, Arwen J., Brinkhorst, Govert, Sibbles, Barbara, Hendriks, Tom, Feith, Sander W.W., Lincke, Carsten R., Brandsma, Annelies E., Brand, Paul L.P., Hop, Wim C.J., de Hoog, Matthijs, and Merkus, Peter J.F.M.

Abstract

Background:Treatment of hospitalized infants with respiratory syncytial virus (RSV) bronchiolitis is mainly supportive. Bronchodilators and systemic steroids are often used but do not reduce the length of hospital stay. Because hypoxia and airways obstruction develop secondary to viscous mucus in infants with RSV bronchiolitis, and because free DNA is present in RSV mucus, we tested the efficacy of the mucolytic drug recombinant human deoxyribonuclease (rhDNase).

Published
2007
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