120 results on '"Bogani, Giorgio"'
Search Results
2. Mirvetuximab soravtansine-gynx: first antibody/antigen-drug conjugate (ADC) in advanced or recurrent ovarian cancer.
- Author
-
Bogani, Giorgio, Coleman, Robert L., Vergote, Ignace, van Gorp, Toon, Ray-Coquard, Isabelle, Oaknin, Ana, Matulonis, Ursula, O'Malley, David, Raspagliesi, Francesco, Scambia, Giovanni, and Monk, Bradley J.
- Published
- 2024
- Full Text
- View/download PDF
3. Clinicopathological characteristics of multiple-classifier endometrial cancers: a cohort study and systematic review.
- Author
-
De Vitis, Luigi Antonio, Schivardi, Gabriella, Caruso, Giuseppe, Fumagalli, Caterina, Vacirca, Davide, Achilarre, Maria Teresa, Aloisi, Alessia, Garbi, Annalisa, Zanagnolo, Vanna, Aletti, Giovanni, Guerini-Rocco, Elena, Mariani, Andrea, Maggioni, Angelo, Barberis, Massimo, Bogani, Giorgio, Colombo, Nicoletta, Multinu, Francesco, and Betella, Ilaria
- Published
- 2024
- Full Text
- View/download PDF
4. HPV-related lesions after hysterectomy for high-grade cervical intraepithelial neoplasia and early-stage cervical cancer: A focus on the potential role of vaccination
- Author
-
Bogani, Giorgio, Sopracordevole, Francesco, Ciavattini, Andrea, Ghelardi, Alessandro, Vizza, Enrico, Vercellini, Paolo, Casarin, Jvan, Pinelli, Ciro, Ghezzi, Fabio, De Vincenzo, Rosa, Di Donato, Violante, Golia D’augè, Tullio, Giannini, Andrea, Sorbi, Flavia, Petrillo, Marco, Capobianco, Giampiero, Vizzielli, Giuseppe, Restaino, Stefano, Cianci, Stefano, Scambia, Giovanni, and Raspagliesi, Francesco
- Abstract
Objective: To date, no data supports the execution of vaccination after hysterectomy for high-grade cervical intraepithelial neoplasia (CIN2+) and early-stage cervical cancer. We aim to evaluate the potential effect of vaccination after hysterectomy for high-grade cervical intraepithelial neoplasia and early-stage cervical cancer.Methods: This is a multi-center retrospective study evaluating data of women who develop lower genital tract dysplasia (including anal, vulvar and vaginal intra-epithelial neoplasia) after having hysterectomy for CIN2+ and FIGO stage IA1- IB1 cervical cancer.Results: Overall, charts for 77 patients who developed lower genital tract dysplasia were collected. The study population included 62 (80.5%) and 15 (19.5%) patients with CIN2+ and early-stage cervical cancer, respectively. The median (range) time between hysterectomy and diagnosis of develop lower genital tract dysplasia was 38 (range, 14-62) months. HPV types covered by the nonavalent HPV vaccination would potentially cover 94.8% of the development of lower genital tract dysplasia. Restricting the analysis to the 18 patients with available HPV data at the time of hysterectomy, the beneficial effect of nonvalent vaccination was 89%. However, considering that patients with persistent HPV types (with the same HPV types at the time of hysterectomy and who developed lower genital tract dysplasia) would not benefit from vaccination, we estimated the potential protective effect of vaccination to be 67% (12 out of 18 patients; four patients had a persistent infection for the same HPV type(s)).Conclusions: Our retrospective analysis supported the adoption of HPV vaccination in patients having treatment for HPV-related disease. Even in the absence of the uterine cervix, HPV vaccination would protect against develop lower genital tract dysplasia. Further prospective studies have to confirm our preliminary research.
- Published
- 2024
- Full Text
- View/download PDF
5. Robotic vs. laparoscopic approach in obese patients with endometrial cancer: which is the best? A mini-review
- Author
-
Golia D’Augè, Tullio, Cuccu, Ilaria, De Angelis, Emanuele, Buzzaccarini, Giovanni, D’Oria, Ottavia, Besharat, Aris Raad, Caserta, Donatella, Muzii, Ludovico, Bogani, Giorgio, Di Donato, Violante, and Giannini, Andrea
- Abstract
This literature review aims to analyze available data on minimally invasive surgery (MIS) for the surgical treatment of endometrial cancer (EC) in obese patients and compare the surgical outcomes of patients with EC, treated with robotic and laparoscopic hysterectomy. An extensive literature search was conducted about studies on obese EC women who underwent robotic or laparoscopic hysterectomy. MIS reduces the impact of common adverse effects in obese patients. The robotic approach can ensure many advantages: reduction in blood loss, operative time, and hospital stay; indeed, robotic surgery seems to add other benefits when lymphadenectomy is required. Robotic surgery is more expensive compared to other approaches but considering global cost, this is less expensive than abdominal hysterectomy and its cost decreases with increasing procedural volume. Intra, peri and post-operative outcomes of obese patients with endometrial carcinoma treated with mininvasive surgery have been analyzed, highlighting the advantages and disadvantages of this approach. However, the gold standard between classical laparoscopy and robotic laparoscopy has not been defined. Robotic surgery shows better surgical outcomes, but its potential is limited due to its costs and long operating times. However, oncologic outcomes remain the most important aspects and are still to be defined.
- Published
- 2024
- Full Text
- View/download PDF
6. Pharmacotherapy for the treatment of recurrent cervical cancer: an update of the literature
- Author
-
D’Oria, Ottavia, Bogani, Giorgio, Cuccu, Ilaria, D’Auge, Tullio Golia, Di Donato, Violante, Caserta, Donatella, and Giannini, Andrea
- Abstract
ABSTRACTIntroductionCervical cancer is the fourth most common cause of cancer-related death worldwide. High-risk locally advanced or recurrent/metastatic cervical cancers have a poor prognosis with routine treatments. The objective of this study is to analyze the data available in the literature on therapies and molecules currently in use to improve the prognosis of recurrent cervical cancer.Areas coveredAn extensive literature search was conducted by authors to identify relevant trials on various databases. Articles in English published until September 2023 that investigate different pharmacotherapy strategies for the treatment of recurrent cervical cancer, were included. Results of various pharmacological regimens including different combinations of chemotherapy, immune checkpoint inhibitors, DNA damage repair inhibitors and antibody-drug conjugates were analyzed.Expert opinionIn recent years, there have been significant improvements in the outcomes of recurrent/metastatic cervical cancer. However, these improvements do not address the unmet need in terms of oncological outcomes. The introduction of immunotherapy and targeted therapies showed advantages in cervical cancer patients. New therapies and combination strategies must be implemented. Centralization of care and enrollment in clinical trials are of paramount importance. Primary and secondary prevention remains the fundamental goal to reduce the burden of cervical cancer.
- Published
- 2024
- Full Text
- View/download PDF
7. Gestational choriocarcinoma.
- Author
-
Bogani, Giorgio, Ray-Coquard, Isabelle, Mutch, David, Vergote, Ignace, Ramirez, Pedro T., Prat, Jaime, Concin, Nicole, Yan Li Ngoi, Natalie, Coleman, Robert L., Takayuki Enomoto, Kazuhiro Takehara, Denys, Hannelore, Lorusso, Domenica, Masashi Takano, Satoru Sagae, Wimberger, Pauline, Segev, Yakir, Se Ik Kim, Jae-Weon Kim, and Herrera, Fernanda
- Published
- 2023
- Full Text
- View/download PDF
8. Pelvic Neuro-Visualization: An Anatomical Illustration of the Autonomic Pelvic Nervous Network in Gynecologic Surgery.
- Author
-
Ditto, Antonino, Ferla, Stefano, Martinelli, Fabio, Bogani, Giorgio, Leone Roberti Maggiore, Umberto, and Raspagliesi, Francesco
- Abstract
During radical pelvic surgeries fibers of the autonomic pelvic nervous network can be accidentally damaged leading to significant visceral sequelae, which dramatically affect women's quality of life because of urinary, anorectal, and sexual postoperative dysfunctions.
1 , 2 Direct visualization is one way to preserve hypogastric nerves (HNs), pelvic splanchnic nerves (PSNs), and the bladder branches from the inferior hypogastric plexus (IHP). However, the literature lacks critical photos and/or illustrations that are necessary to understand the precise anatomy needed to preserve the pelvic autonomic fibers. Narrated laparoscopic video footage for identifying, dissecting, and preserving the autonomic nerve bundles during pelvic surgery. Tertiary level hospital—"IRCCS Istituto Nazionale dei Tumori", Milano, Italy. Visceral pelvic innervation is established by the superior hypogastric plexus(SHP) located anteriorly to the aortic bifurcation and the median sacral vessels and carries mostly sympathetic fibers. SHP divides in front of the sacrum into the right and left HN. At the level of the paracervix, the HNs join the parasympathetic PSNs coming out from sacral root S2, S3, S4 to form the IHP.2–5 Here, we performed laparoscopic surgery, before "Laparoscopic Approach to Cervical Cancer" trial (LACC) era, identifying key anatomic landmarks useful to highlight the path of the most commonly encountered autonomic pelvic nerves in gynecologic radical surgery: during the narration we describe and illustrate the procedure to identify all autonomic pelvic nerves, the sympathetic fibers, the PSNs, and the bladder branch emerging from the IHP in order to preserve their anatomic and functional integrity. This technique is anatomically and surgically indicated for adequate removal of the parametrical issues and vagina while preserving the total pelvic nervous system. Nerve-sparing surgery reduces bowel-, bladder- and sexual- dysfunction without decreasing surgical efficacy.1 , 2 To accomplish safe and effective surgery, comprehension of the 3 dimensional structure of the vascular and nerve anatomy in the pelvis is essential. This video provides a great resource to educate surgeons, especially the youngest ones, about the retroperitoneal nervous networking: we identified the autonomic nerve pathway from adjacent tissues along the pathway consisting of cardinal, sacro-uterine, rectouterine/vaginal, and vesico-uterine ligaments. [Display omitted] [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
9. Human papillomavirus (HPV) vaccination: a call for action in Italy.
- Author
-
Bogani, Giorgio, Ghelardi, Alessandro, Sopracordevole, Francesco, Annoni, Marco, Ciavattini, Andrea, Giannella, Luca, De Vincenzo, Rosa, Cattani, Paolo, Barbero, Maggiorino, Vercellini, Paolo, Raspagliesi, Francesco, Bonanni, Paolo, and Scambia, Giovanni
- Published
- 2023
- Full Text
- View/download PDF
10. Magnetic resonance imaging-radiomics in endometrial cancer: a systematic review and meta-analysis.
- Author
-
Di Donato, Violante, Kontopantelis, Evangelos, Cuccu, Ilaria, Sgamba, Ludovica, D'Augè, Tullio Golia, Pernazza, Angelina, Rocca, Carlo Della, Manganaro, Lucia, Catalano, Carlo, Perniola, Giorgia, Palaia, Innocenza, Tomao, Federica, Giannin, Andrea, Muzii, Ludovico, and Bogani, Giorgio
- Published
- 2023
- Full Text
- View/download PDF
11. Surgical Outcomes and Complications of Laparoscopic Hysterectomy for Endometriosis: A Multicentric Cohort Study.
- Author
-
Casarin, Jvan, Ghezzi, Fabio, Mueller, Michael, Ceccaroni, Marcello, Papadia, Andrea, Ferreira, Helder, Uccella, Stefano, Malzoni, Mario, Mabrouk, Mohamed, Seracchioli, Renato, Bordi, Giulia, Gisone, Baldo Emanuele, Vaineau, Cloé, Bogani, Giorgio, Roviglione, Giovanni, Arena, Alessandro, Ambrosoli, Andrea Luigi, Graf, Carla, Bruni, Francesco, and Bras, Rafael
- Abstract
To investigate the postoperative morbidity of laparoscopic hysterectomy (LH) for endometriosis/adenomyosis in terms of operative outcomes and complications. Retrospective multicentric cohort study. Eight European minimally invasive referral centers. Data from 995 patients with pathologically confirmed endometriosis and/or adenomyosis who underwent LH without concomitant urological and/or gastroenterological procedures from January 2010 to December 2020. Total LH. Demographic patients' characteristics, surgical outcomes, and intraoperative and postoperative complications were evaluated. We considered major postoperative surgical-related complications, any grade 2 or more events (Clavien-Dindo score) that occurred within 30 days from surgery. Univariate analysis and multivariable models fit with logistic regression were used to estimate the adjusted odds ratio (OR) and corresponding 95% confidence interval (CI) for major complications. Median age at surgery was 44 years (28–54), and about half of them (505, 50.7%) were on medical treatment (estro-progestins, progestin, or Gonadotropin hormone-releasing hormone-analogues) at the time of surgery. In association with LH, posterior adhesiolysis was performed in 387 (38.9%) cases and deep nodule resection in 302 (30.0%). Intraoperative complications occurred in 3% of the patients, and major postoperative complications were registered in 93 (9.3%). The multivariable analysis showed an inverse correlation between the occurrence of Clavien-Dindo >2 complications and age (OR 0.94, 95% CI 0.90–0.99), while previous surgery for endometriosis (OR 1.62, 95% CI 1.01–2.60) and intraoperative complications (OR 6.49, 95% CI 2.65–16.87) were found as predictors of major events. Medical treatment at the time of surgery has emerged as a protective factor (OR 0.50, 95% CI 0.31–0.81). LH for endometriosis/adenomyosis is associated with non-negligible morbidity. Knowing the factors associated with higher risks of complications might be used for risk stratification and could help clinicians during preoperative counseling. The administration of estro-progestin or progesterone preoperatively might reduce the risks of postoperative complications following surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
12. Relapse Patterns in Early-Stage Endometrial Cancer Based on Molecular Classification
- Author
-
Bogani, Giorgio and Raspagliesi, Francesco
- Published
- 2024
- Full Text
- View/download PDF
13. Endometrial carcinosarcoma.
- Author
-
Bogani, Giorgio, Ray-Coquard, Isabelle, Concin, Nicole, Yan Li Ngoi, Natalie, Morice, Philippe, Caruso, Giuseppe, Enomoto, Takayuki, Takehara, Kazuhiro, Denys, Hannelore, Lorusso, Domenica, Coleman, Robert, Vaughan, Michelle M., Masashi Takano, Provencher, Diane Michele, Sagae, Satoru, Wimberger, Pauline, Póka, Robert, Segev, Yakir, Se Ik Kim, and Jae-Weon Kim
- Published
- 2023
- Full Text
- View/download PDF
14. Sentinel node mapping, sentinel node mapping plus back-up lymphadenectomy, and lymphadenectomy in Early-sTage cERvical caNcer scheduled for fertilItY-sparing approach: The ETERNITY project.
- Author
-
Bogani, Giorgio, Scambia, Giovanni, Fagotti, Anna, Fanfani, Francesco, Ciavattini, Andrea, Sopracordevole, Francesco, Malzoni, Mario, Casarin, Jvan, Ghezzi, Fabio, Vizza, Enrico, Cosentino, Francesco, Berretta, Roberto, Cuccu, Ilaria, Ferrari, Filippo Alberto, Chiappa, Valentina, Vizzielli, Giuseppe, and Raspagliesi, Francesco
- Subjects
SENTINEL lymph nodes ,CERVICAL cancer ,LOG-rank test ,OVERALL survival ,CONIZATION ,MICROMETASTASIS - Abstract
To investigate the safety of sentinel node mapping for patients with early-stage cervical cancer undergoing cervical conization plus nodal evaluation. The ETERNITY project is a retrospective, multi-institutional study collecting data of patients with early-stage cervical cancer undergoing fertility-sparing treatment. Here, we compared outcomes related to three methods of nodal assessment: sentinel node mapping (SNM), SNM plus backup lymphadenectomy (SNM + LND); pelvic lymphadenectomy (LND). Charts of 123 patients (with stage IA1-IB1 cervical cancer) were evaluated. Median patients' age was 34 (range, 22–44) years. SNM, SNM + LND, and LND were performed in 32 (26 %), 31 (25.2 %), and 60 (48.8 %) patients, respectively. Overall, eight (6.5 %) patients were diagnosed with positive nodes. Two (3.3 %), three (9.7 %), and three (9.4 %) patients were detected in patients who had LND, SNM + LND, and SNM respectively. Considering the 63 patients undergoing SNM (31 SNM + LND and 32 SNM alone), macrometastases, micrometastases, and isolated tumor cells were detected in four (3.2 %), three (2.4 %), and one (0.8 %) patients, respectively. All patients with positive nodes discontinued the fertility sparing treatment. Other two patients (one (1.7 %) in the LND group and one (3.1 %) in the SNM group) required hysterectomy even after negative nodal evaluation. After a median follow-up of 53.6 (range, 1.3, 158.0) months, nine (7.3 %) and two (1.6 %) patients developed cervical and pelvic nodes recurrences, respectively. Disease-free (p = 0.332, log-rank test) and overall survival (p = 0.769, log-rank test) were similar among groups. In this retrospective experience, SNM upholds long-term oncologic effectiveness of LND, reducing morbidity. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
15. BYL719 (alpelisib) for the treatment of PIK3CA-mutated, recurrent/advanced cervical cancer
- Author
-
Bogani, Giorgio, Chiappa, Valentina, Bini, Marta, Ronzulli, Dominique, Indini, Alice, Conca, Elena, and Raspagliesi, Francesco
- Abstract
Purpose: Advanced/recurrent cervical cancer has limited therapeutic options, with a median progression-free survival after the failure of systemic treatments ranging between 3.5 and 4.5 months. Here, we reported our preliminary experience in the use of BYL719 (alpelisib) in advanced/recurrent cervical cancer after failure of at least 2 lines of treatment. The Istituto Nazionale dei Tumori di Milano approved this investigation.Methods: From April 2020 to September 2020, 17 consecutive patients with recurrent cervical cancer had Next Generation Sequencing (NGS). Of these, six patients harboring the PIK3CA mutation were included in the study. All patients had been treated with at least 2 previous lines of systemic treatment: 3 patients received >2 prior lines of treatment in the recurrent or metastatic setting; 60% had received prior bevacizumab in combination with chemotherapy. All patients started alpelisib at the daily dosage of 300 mg.Results: Investigator-assessed confirmed objective response rate (ORR) was 33%. The disease control rate (DCR) was 100%. According to RECIST 1.1, two patients had a partial response (PR), and four patients had stable disease (SD). No complete response was observed. The mean duration of response (DOR) was 11.5 (SD 3.75) months; five patients had PR lasting for >9 months. One patient stopped the treatment at 0.82 months due to the onset of a grade 2 adverse event (AE) (skin rash). Grade 3 treatment-related AEs included: lymphoedema (n = 1, 17%) and rash (n = 1, 17%). No treatment-related grade 4-5 AEs occurred.Conclusions: Our preliminary data highlighted a high level of efficacy in this setting of patients. Further trials are needed to assess the safety and effectiveness of alpelisib in PIK3CA-mutated recurrent/advanced cervical cancer.
- Published
- 2023
- Full Text
- View/download PDF
16. Advances in small molecule maintenance therapies for high-grade serous ovarian cancer
- Author
-
Fischetti, Margherita, Di Donato, Violante, Palaia, Innocenza, Perniola, Giorgia, Tomao, Federica, Perrone, Chiara, Giancotti, Antonella, Di Mascio, Daniele, Monti, Marco, Muzii, Ludovico, Benedetti Panici, Pierluigi, and Bogani, Giorgio
- Abstract
ABSTRACTIntroductionOvarian cancer is one of the most lethal gynecological tumors with a lack of effective treatment modalities especially in advanced/recurrent disease. Nevertheless, recently, new small molecules have emerged as an effective approach for the management of ovarian cancer patients, especially in the maintenance setting.Areas coveredThis review summarizes the role of small molecules used in the management of high-grade serous ovarian cancer. The authors performed a critical review of current evidence and ongoing studies. Of note, tyrosine kinase inhibitors (TKIs) and poly(ADP-ribose) polymerase (PARP) inhibitors are the most intriguing medications in this setting.Expert opinionProtein-targeted therapies against tumor tissues have progressed significantly in the last years due to an enhanced knowledge of the biological and molecular processes of carcinogenesis. Treatment with small molecules allows the targeting of specific proteins involved in cancer biology. TKIs seem promising but further data are necessary to assess the pros and cons of adopting this treatment modality. PARP inhibitors represent the new standard of care for ovarian cancer patients harboring either a BRCA mutation or with homologous recombination deficiency (HRD). Interestingly, the accumulation of data has highlighted that PARP inhibitors provide benefits even in patients with HR proficient tumors.
- Published
- 2023
- Full Text
- View/download PDF
17. An update on current pharmacotherapy for vulvar cancer
- Author
-
Bogani, Giorgio, Palaia, Innocenza, Perniola, Giorgia, Tomao, Federica, Giancotti, Antonella, Di Mascio, Daniele, Capalbo, Giuseppe, Muzii, Ludovico, Benedetti Panici, Pierluigi, and Di Donato, Violante
- Abstract
ABSTRACTIntroductionLimited data on the role of pharmacotherapy for patients with locally advanced, recurrent, or metastatic vulvar cancer are available.Areas coveredThis article aims to provide an overview of the current treatment options for patients with vulvar cancer. PubMed (MEDLINE), Embase, CENTRAL, Scopus, and Web of Science databases, as well as ClinicalTrials.gov were searched to review the current evidence as well as future perspectives on the role of pharmacotherapy in patients with vulvar carcinoma.Expert opinionThere has been no consensus on the pharmacotherapy for patients with locally advanced, recurrent, or metastatic vulvar cancer. Concurrent platinum-based chemoradiation is the most widely used treatment modality for primary treatment or for neoadjuvant settings. Chemotherapy in metastatic disease is considered a palliative treatment. Anti-EGFR tyrosine kinase inhibitors seem to show promising anti-tumor activity in patients harboring EGFR alteration. Similarly, growing evidence supports the adoption of immune checkpoint inhibitors in both neoadjuvant and metastatic settings. Molecular and genomic profiling is advocated to identify target mutations. The PI3K/AKT/mTORand HER/ErbBpathways might represent two intriguing treatment options. Treatments directed against HPV are discussed as well. Further evidence is warranted to identify the best treatment modalities for patients with locally advanced, recurrent, and metastatic disease.
- Published
- 2023
- Full Text
- View/download PDF
18. Chemo-surgical approach in vulvar leiomyosarcoma: A case report
- Author
-
Capalbo, Giuseppe, Logoteta, Alessandra, Gallo, Roberta, Cuccu, Ilaria, Gentile, Gabriella, Arienzo, Francesca, Musella, Angela, Pernazza, Angelina, Perniola, Giorgia, Di Donato, Violante, Manganaro, Lucia, Bogani, Giorgio, and Palaia, Innocenza
- Abstract
Introduction: Primary sarcoma of the vulva is an extremely rare entity, representing only 1%–3% of all vulvar malignant neoplasms. Among sarcomas, leiomyosarcoma (LMS) is the most prevalent histologic variant. Due to the rarity of LMS, guidelines are lacking and phase III trials have not been carried out, so clinical management is based on local clinical practice and physician experience.Case presentation: Here, we described a case of primary LMS of the vulva and its successful management, with the adoption of neoadjuvant chemotherapy and surgery. We report a case of a 74-year-old woman with 12.5 cm vulvar LMS. The patient received three cycles of neoadjuvant chemotherapy with a partial response. Radical vulvectomy with vulvar reconstruction with V-F flap was carried out. Surgical margins were negative. Three additional cycles of adjuvant chemotherapy were delivered.Results: One year after treatment, the patient was disease-free.Conclusion: There are no approved therapeutic protocols for this rare neoplasia. Surgery is the mainstay of treatment. However, it is not always feasible, so neoadjuvant chemotherapy was delivered for downstaging the vulvar lesion. We suppose that neoadjuvant chemotherapy has optimized the possibilities of radical surgery. Despite the anectodical nature of this case presentation, neoadjuvant chemotherapy seems a valid therapeutic option for managing patients with bulky vulvar sarcoma. Further large collaborative studies are warranted to identify the best therapeutic option for these patients.
- Published
- 2022
- Full Text
- View/download PDF
19. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
- Author
-
Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Davidson, Giana H, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Ford, Samuel, Garmanova, Tatiana, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gruendl, Magdalena, Halkias, Constantine, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jenkinson, Michael D, Jonker, Pascal, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Modolo, Maria Marta, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn van der, Qureshi, Ahmad, Radenkovic, Dejan, Ramos-De La Medina, Antonio, Revell, Elliot J, Roberts, Keith, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Townend, Philip, Tsoulfas, Georgios, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, EuroSurg, NA, European Society of Coloproctology (ESCP), NA, Global Initiative for Children's Surgery, NA, GlobalSurg, NA, GlobalPaedSurg, NA, ItSURG, NA, PTSurg, NA, SpainSurg, NA, Italian Society of Colorectal Surgery, NA, Association of Surgeons in Training, NA, Irish Surgical Research Collaborative (ISRC), NA, Transatlantic Australasian Retroperitoneal Sarcoma Working, NA, Italian Society of Surgical Oncology, NA, Booth, Lesley, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Bahrami-Hessari, Mike, Riaz, Asad, Shah, Jaffer, Safi, Mohammed, Thereska, Dariel, Dajti, Irida, Cheddadi, Riadh, Tidjane, Anisse, Quinteros, Carlos A, khelfaoui, Ahmed, Salem, Khalifa M, Riffi, Omar, Kacimi, Salah Eddine O, Loudjedi, Salim, Damerdji, Tidjani, Pantoja Pachajoa, Diana A, Palacios Huatuco, René M, Alvarez, Fernando A, Doniquian, Alejandro M, Abeldaño Zuñiga, Roberto A, Schlottmann, Francisco, Cobos, Carlos M, Gigena, Cecilia, Forneris, Agustin Albani, Duro, Agustin, García-Mansilla, Agustín M, Busnelli, Virginia Cano, Poggi, Catalina, Mercado, Pedro L, González, Marcos, Castro Lalin, Agustina F, Mayer, Horacio F, Brandariz, Rodrigo, Slullitel, Pablo A, Boudou, Rocio, Lobos, Pablo A, Uffelmann, María C, Petersen, Maria L, Luzzi, Emilia, Padilla Lichtenberger, Fernando L, Crespi Amor, María S, Zarratea, Celeste S, Esteves, Tomas A, Gemelli, Nicolas A, Tirapegui, Sebastián, Liyo, Juan, Scherñuk, Jordán, Boccalatte, Luis A, Balmaceda, Ruben D, D'Addino, Jose L, Caubet, María M, Calderón Arancibia, José A, Chwat, Carina, Morris, Brian, Avellaneda, Nicolas, Pedraza Salazar, Ivana I, Eskinazi, Diego G, Vargas, Lara, Muriel, María E, Lucchini, Sergio M, Gosselink, Martijn P, Davis, Amelia L, Barker, John C, Qin, Kirby R, Proud, David M, Cox, Daniel RA, Goh, Su Kah, Liu, David S, Wu, Damien M, Merrett, Neil D, Badiani, Sarit S, Sengupta, Shomik, Jain, Anshini, Steen, Christopher J, Wong, Enoch, Ip, Christopher CK, Leaning, Matthew G, McCartney, Conor B, Gananadha, Sivakumar, Yeap, Evie FW, Stevens, Sean G, Vu, Anh N, Martin, Sarah A, Stanley, Guy H M, Watson, David I, Townend, Philip J, Young, Thomas K, Cox, Georgia T, Dawson, Amanda C, Laura, Sharon E, Lun, Elizabeth W Y, Liang, Ina X, O'Neill, Christine J, Lott, Natalie J, Chuan, Alwin, Saravanan, SK, Gundara, Justin, Ong, Bee Shan, Nataraja, Ramesh M, Pacilli, Maurizio, Foley, Daniel M, Ooi, Geraldine J, Traeger, Luke, MacDermid, Ewan, Daruwalla, Jurstine, Hodgson, Russell, Heriot, Alexander G, Mulligan, Christopher S, Blefari, Nicholas D A, Purcell, Shaun S, Frankel, Adam J, Guerra, Glen R, Tefay, Joan S, Liang, Rhea W Y, Kroon, Hidde M, Farfus, Anthony W, Warren, Leigh R, Roy, Jennifer M, Whitfield, Robert J, Moller, Cea-Cea B, Davis, Sean S, Sammour, Tarik, Lam, Yick Ho, Kour, Kevin, Gan, Siang Wei, Coventry, Brendon J, Dawson, Joseph A, Batstone, Martin D, King, Sebastian K, Scott, Nathan J, Foo, Jonathan W, Shepherd, Talia, Page, Richard S, Choong, Peter F, Badgery, Henry E, Chong, Lynn, Taylor, Lillian, Hii, Michael W, Wright, Gavin M, Kong, Joseph CH, Watson, Matthew M, Bock, Jacob, Lidder, Surjit S, Elias, Patrick, Kanavathy, Sathisvaran, Koh, Cherry E, Chennakesavan, Srinivas Kondalsamy, Panuganti, Vishwakar, Latif, Haider, Yeung, Justin MC, Besson, Alex J, Tse, Eunice Q Y, Pitcher, Meron E, Taylor, Danielle L, Nahm, Christopher B, Lim, Alicia, Tree, Kevin, Aigner, Felix, Dawoud, Christopher, Foessleitner, Philipp, Zimmermann, Matthias, Wiedemann, Dominik, Findl, Oliver, Messner, Franka, Bauer, Marlies, Nägele, Felix, Kronberger, Irmgard E, Öfner, Dietmar, Härter, Bettina, Bicz, Nina Ru B, Zwittag, Paul M, Poier, Nikolaus, Navarro, Francisco Ruiz, Zebuhr, Yorck A, Köglberger, Paul, Wiesinger, Clemens G, Mathew, Erwin, Trivik-Barrientos, Felipe, Königsrainer, Ingmar, Djedovic, Gabriel, Cohnert, Tina U, Lumenta, David B, Singer, Georg, Leithner, Andreas, Kamolz, Lars-Peter, Andrianakis, Alexandros, Puchwein, Paul, Mikalauskas, Saulius, Kirchweger, Patrick, Függer, Reinhold, Mittermair, Christof, Russe, Elisabeth, Paal, Peter, Grünbart, Martin, de Cillia, Michael, Weiss, Helmut G, Steiner, Florian, Binder, Alf Dorian, Samadov, Elgun, Ibrahimli, Arturan, Muslumov, Gurbankhan, Bayramov, Nuru Y, Saunders, Jada M, Almoosa, Noora, Haj-Ibrahim, Huzifa, Maresch, Martin, Ezzdean, Weaam K, Juma, Isam M, Hasan, Layla H, Haider, Fayza HA, Alfaqawi, Ghassan Salman, Alam, Mohammed S, Islam, Shahnoor, Basher, AKM K, Mitul, Ashrarur Rahman, Islam, Nazmul, Oosterkamp, Antje E, Ahmed, Tanveer, Hannan, M Jafrul, Padmore, Greg M, Doyle, Alex F, LaCorbiniere, Karisha L, Boyce, Rico D R, Ragoobar, Paul T, Walkes, Keisha M Y, Haynes, Amelia A, Corbin, Sasha M, Litvina, Yauheniya A, Makhmudov, Anvar, Strypstein, Sébastien, Dhondt, Bert, Rasschaert, Ricky, Farid, Yasser, Wahib, El Mahdi, Pigeolet, Manon, Belle, Koen Van, De Wachter, Stefan, Komen, Niels, Vandeputte, Mathieu PJ, van Ramshorst, Gabrielle H, Jansen, Yanina JL, Stijns, Jasper, Eynde, Jef Van den, Olowo, Benedicte I, Feraudy, Israel C, Dragisic, Vedran, Martinovic, Vlatka, Barišić, Tatjana, Penava, Nikolina, Hudic, Igor, Delibegovic, Samir, Bogdanović, Gordana, Grgić, Gordana, Cerovac, Anis, Cerovac, Elmedina, Bedada, Alemayehu G, Baiocchi, Glauco, Wainstein, Alberto, Moisés, Elaine Christine D, Zani, Ana Carolina Tagliatti, de Campos Prado, Caio Antonio, Panis, Carolina, Rech, Daniel, Soares da Silva, Ruan Gabriel, Joviliano, Edwaldo E, Rezende, Ricardo F, Reis, Igor G N, Pires, Robinson E S, Christiano, Adriana Borgonovi, Consani, Heitor F X, Pugliesi, Felipe G, Takeda, Flavio R, Mariani, Alessandro W, Valadares, Ricardo J B, Andreollo, Nelson A, Lopes, Luiz Roberto, Tonello, Cristiano, Alonso, Nivaldo, dos Santos, Carlos Ferreira, Lima, Leonardo S, Salgado, Wilson, Pereira, Thiago H S, Gatti, Arthur Paredes, Oliva, Ramon N L, Nardi, Caroline N, Sousa, Alvaro F L, Ribeiro, Ivonizete P, Carvalho, Herica E F, Oliveira, Layze B, Schneider, Guilherme, Casteleins, William Augusto, Silva, Larissa M, Gomes, Carlos Augusto, da Cunha Viana Júnior, Alonço, Cruz, Ricardo P, Gomes, Gustavo MA, Buarque, Igor L, Barros, Aldo V, Marangon, Gustavo B, Flumignan, Ronald LG, Nakano, Luís CU, Pascoal, Patrícia IF, Santos, Brena C, Kuramoto, Danielle AB, Correia, Rebeca M, Amaral, Fabio CF, Flumignan, Carolina DQ, Dussán-Sarria, Jairo A, Simões, Romeo L, Casteleins, William Augusto, Amorim, Robson L, Silva, Jeancarllo S, Lyra Junior, Humberto F, Julio, Nathalia S, Gerber, Marlus T, dos Santos, José Mauro, de Oliveira, Joao Carlos C, Palamim, Camila VC, Marson, Fernando AL, Gomes, Iolanda M, Oliveira, Priscila R, Lima, Ana Lucia L M, Carvalho, Vladimir C, Silva, Jorge S, NA, Ulysses Ribeiro, Laporte, Gustavo Andreazza, Gonçalves, Mateus Capuzzo, Botacin, Lais S, Avelino, Melissa AG, Brito, Luiz Gustavo O, Hristova, Evguenia T, Stoyanov, Vladislav Valentinov, Sakakushev, Boris E, Dardanov, Dragomir D, Sokolov, Manol B, Mehta, Ananya, Gyokova, Elitsa H, Abdullahi, Mohamed, Karamanliev, Martin P, Dimitrov, Dobromir D, Slavchev, Mihail T, Atanasov, Boyko Ch, Yotsov, Tsanko I, Hadzhiev, Dimitar Bozhidarov, Stock, Simon E, Nwegbu, Chukwuemeka Gerald, Tanyi, Tanyi John, Brown, James A, Arneja, Jugpal S, Lee, Susan M, Kancherla, Ramya, Kidane, Biniam, Champagne, Pierre-Olivier, Ma, Xiya, Munro, Allana, McKeen, Dolores M, Martin, Janet, Glinka, Juan, Vasarhelyi, Edward M, Subramani, Yamini, Alfaro, Hilda, Shah, Ushma J, Gonzalez, Nelson J, MacNeil, S Danielle, Nagappa, Mahesh, Malthaner, Richard A, Brackstone, Muriel, Alkhamesi, Nawar A, Qiabi, Mehdi, Arango-Ferreira, Camila, Prempeh, Agya B A, Dumitra, Sinziana, Spence, Richard T, Bedard, Eric LR, Lee, Susan M, Luc, Jessica GY, Johnston, Brian R, Attabib, Najmedden, Persad, Amit RL, Das, Sunit, Khoshbin, Amir, Ladha, Karim S, Sankar, Ashwin, Teja, Bijan, Daza, Julian F, Chan, Veronica F, Baertschiger, Reto M, Zani, Augusto, Nessim, Carolyn, McIsaac, Daniel I, Singh, Mandeep, Behzadi, Abdollah, Dell, Angela J, Al Riyami, Salim M, Dajani, Khaled Z, Bigam, David, Manikala, Vinod K, Street, John T, Mayson, Kelly V, Wallis, Christopher J D, Mimica, Ximena, Modolo, Maria Marta, Villanueva, Julio, Altamirano, Roberto, Waissbluth, Sofia, Marín, Diego I, Olivos, Maricarmen, Fonseca, Bruno Catoia, Hodali, Andrés J, Ramos, Andrea I, Valenzuela, Marco A, Torres, Janina J, Song, Yi, Yang, Wah, Safi, Mohammed, Aldanakh, Abdullah, Alradhi, Mohammed, Lyu, Yidong, Chen, Yan, Fletcher, Angélica V, Camargo, Daniela, Casanova, Rafael Figueroa, Medina, Camilo Andres Caicedo, Bolivar, Dinimo, Garcia, Tatiana Carolina Beltran, Pedraza, Nestor F, Garcia-Lopez, Andrea, Patino-Jaramillo, Nasly G, Giron, Fernando A, Rivera, Carlos J- Perez, Nieto-Calvache, Albaro José, Ariza, Fredy, Orozco-Chamorro, Claudia Milena, Nanez, Maria A, Garces, Diana S, Figueroa, Luis M, Badiel, Marisol, Martinez, Delio F, Coll-Tello, Brenda, Camelo, Hector F, Montoya Casella, Antonio J, Ordoñez, Sebastian, Velez Sanchez, Paola A, Salcedo, Juan C, Villegas, Lina M, Holguín, Jorge A, Cardozo, Jesús Hernán Tovar, Perdomo, Jorman Harvey Tejada, Perdomo, Valentina Gutiérrez, Rivera-Rincon, Natalia A, Gomez, Paula Torres, Delgado-Nieto, Elena Leonor, Isaza-Restrepo, Andres, Vargas, Felipe, Vargas, Ana M, Castro, Arnulfo Andrade, Navarro, Jorge A, Vargas, Saul E, Calvache, Jose A, Mendoza-Arango, Maria C, Bernal, Jorge Luis Vélez, Gonzalez, Felipe O, šantak, Goran, Kirac, Iva, Kršul, Dorian, Versic, Ana Bosak, Augustin, Goran, Kulis, Tomislav, Kastelan, Zeljko, Hadzibegovic, Ana Danic, Grsic, Kresimir, Hudolin, Tvrtko, Tarle, Marko, Mamic, Matija, Lorencin, Mia, Luksic, Ivica, Habek, Dubravko, Konjevoda, Suzana, Mihanovic, Jakov, Antoniou, Stavros A, Almezghwi, Heyam A, Gouvas, Nikolaos, Martinek, Lubomir, Novysedlak, Rene, Žatecký, Jan, Christensen, Peter, Meyhoff, Christian S, Ellebæk, Mark Bremholm, Batista, Sylvia Jeanne, Rodriguez, Julia, Mejia De la Cruz, Dolores, Jimenez, Mirna Giselle Santiago, Dominguez, Carla M, Negrete, José R, Campuzano, Pedro N, Mogrovejo, Daniel L, Armas, Maria J, Arboleda-Bustan, Jenny E, Lincango-Naranjo, Eddy P, El-Kassas, Mohamed, Awad, Ahmed K, Alazab, Emad, Abdulmaseh, Kyrillos G, Diab, Sherein, El Wahab, Mostafa HAbd, Darwesh, Amr, Mostafa, Badr E, Abdelgalil, Mahmoud Shaban, Elbadawy, Merihan A, Reda, Ali M, Asla, Amir Fathi, Fayed, Notaila M, Ahmed, Mohamed S, Elsadek, Menan Ahmed, Gad, Dalia Elsayed, El Saadany, Aya Gameel, Elsadek, Aalaa Mohamed, Asla, Amir Fathi, Sayed, Ahmed E, Naeem, Ahmed, Al-Mallah, Abdullah, Abdelsamed, Ahmed A, Ewedah, Moataz, Soliman, Mohamed O, Tanas, Yousef, Hamouda, Mohammed, Mahfouz, Marina H, Abdo, Manal E, Dean, Yomna E, Lka, Karim, Abodeeb, Aya O, Ashoush, Fouad M F B, Elsherbiny, Roqaia R, Gadelkarim, Mohamed, Osman, Nermin A, MIbrahim, Maya, Youssef, Nehal G, Ibrahim, Mohamed Hamdy, Soliman, Antonios, Gadelkareem, Rabea A, Abbas, Ahmed M, Mohamed Hussein, Aliae AR, Abdelsattar, Khaled, Maher, Ahmed, Elabd, Mohamed M, Abdelazim, Hassan, Ibraheem, Maher H, Noureldin, Yasser A, Elfiky, Mahmoud, Ebrahim, Mohamed A, Abdelrahman, Ahmed Saber Mohamed, Marei, Mahmoud Marei, Elkhalawy, Aya M, Azzam, Ahmed Y, Azab, Mohammed A, Elmasry, Ahmed H, Awad, Ahmed K, Elgazar, Amr, Shalaby, Mahmoud Mohamed Mohamed, Mahmoud, Mohammad S, Qassem, Mohamed G, Kinani, Hussein, Wahba, Abdelrahman M, Elbadawy, Merihan A, Ezzat, Rana Hisham, Ahmed, Mai H, Elshawy, Mohamed Elemam, Faragalla, Hazem Metwally, Mahmoud, Khalid D, Nafea, Ahmed M, Abdel-Maboud, Mohamed, Abozied, Hesham, Moharam, Modather, Shehata, Ashraf H, ElKafrawy, Samir A, Tayiawi, Mosaab M, Elghadban, Hosam M, Emara, Moataz M, Shehta, Ahmed, Saqr, Amira M, Abdelelsalm, Wafaa M, Elshennawy, Eslam M, Radwan, Samar T, Awad, Selmy S, Emile, Sameh H, Aldosoky, Wesam A, Elfeki, Hossam, Gendi, Sara N, Abdelsalam, Hala Adel, Hammad, Mohammed, Shalaby, Mostafa, Sakr, Ahmad Hammad, Abdelmaksoud, Mohamed A, Alawady, Mohammed, Omran, Abdelrahman Azzam, Allam, Abdallah R, Ismail, Zainab, Gaballah, Khaled M, AlGady, Mahmoud Fathy Mahmoud, Raslan, Ahmed M, Gharbia, Khaled, Nuser, Abdelazez A, Sayed, Ahmed Kamal, Al-Mallah, Abdullah, Elshahawy, Mahmoud A, Ghaly, Galal, Sherif, Ahmed Elshawadfy, Makram, Abdelrahman M, Makram, Omar M, Ahmed, Ola, Helmy, AbdelRahman M A, Abdelwahab, Khaled M, Abdelkhalek, Mohamed, Metwally, Islam H, Shetiwy, Mosab Saad, Zuhdy, Mohammad, Ramadan, Salma I, Abdelghany, Mohamed, Omar, Mohammed A, Soliman, Ziad A, Ali, Hossam T, Elnoamany, Salma, Ghozy, Sherief, Abbas, Alzhraa S, Shehata, Mostafa A, Mahmoud, Sahar A, Elsaman, Mohammed A, Fayad, Elsayed A, Radwan, Asmaa, El-Sakka, Ahmed I, Sallam, Asser, Elbahnasawy, Mohamed G, Esmail, Eslam S, Hawila, Ahmed Maher, Hamada, Mohamed K, Motawea, Sara H, Morsy, Mohamed S, El-Sheemy, Hatem Refaat, Ebada, Mahmoud Ahmed, Khedr, Ali H, Gad, Ahmed, Elmandouh, Omar, Elmandouh, Reem, Alkanj, Souad, Youssef, Mohammad G, Awad, Kamal, Mohammed, Maged, Elsayad, Ahmed H, Rätsep, Tõnu, Wolle, Melatework A, Negussie, Abraham G, Adimass, Misganaw A, Misganaw, Bereket Tsegaye, Bezabih, Yoseph S, Assefa, Biniam Zemedu, Shumye, Getachew W, Mengesha, Mengistu G, Gechera, Dagnachew Y, Mohammed, Adnan A, Mulugeta, Gersam A, Metaferia, Yonas Y, Kifetew, Ashebir B, Degefa, Eyueal A, Deressa, Yadani M, Gonfa, Kebebe Bekele, Bedane, Zewdie G, Ayalew, Alem M, Ayele, Henok Teshome, Abebe, Engida, Worku, Bereket Atnafu, Sisay, Million M, Kassa, Dawit Worku, Awedew, Atalel F, Bayable, Abera C, Tiruneh, Abraham Genetu, Hailu, Samuel, Numaro, Yilkal T, Ademe, Yonas, Baleh, Abat S, Megerssa, Thomas B, Kejela, Segni, Derilo, Habtamu T, Akililu, Yemisirach B, Lebbe, Iris, Sarjanoja, Elise K, Kauppila, Joonas H, Sinikumpu, Juha-Jaakko, Giordano, Salvatore, Kantor, Elie, Soussan, Romy, Tommaso, Cipolat Mis, Nappi, Francesco, Morichau-Beauchant, Tristan, Nahum, Julien, Maillet, Jean-Michel, Godement, Mathieu, Jouffret, Lionel, Migliorelli, Federico, De Simone, Belinda, Brunaud, Laurent, Fuchs-Buder, Thomas, Testelin, Sylvie, Bin, Kim, Boucher, Sophie, Schmitt, Françoise, Lakkis, Zaher, Harper, Luke, Slim, K, Piessen, Guilaume, Eveno, Clarisse, Ballouhey, Quentin, Taibi, Abdelkader, Crenn, Vincent, Duchalais, Emilie, Arnaud, Alexis P, Azzis, Olivier, Tuech, Jean-Jacques, Vaysse, Charlotte, Weyl, Ariane, Vergriete, Kelig, Charbonneau, Helene, Ezanno, Anne-Cecile, Malgras, Brice, Basso, Celeste Del, Duquesne, Igor, Bernabei, Federico, Rothschild, Pierre-Raphaël, Abbo, Olivier, Manceau, Gilles, Chamouni, Alexandre, Crétolle, Célia, Arnalsteen, Laurent, Mikhael, Elie, Police, Andrea, Montero-Macias, Rosa, Villefranque, Vincent, Maisonneuve, Emeline, Langlais, Tristan, Seeliger, Barbara, Pessaux, Patrick, Gonzalez, Cristians A, D'Urso, Antonio, Angeles, Martina A, Seguin-Givelet, Agathe, Des Deserts, Marc Danguy, Gaujoux, Sebastien, de Ponthaud, Charles, Chartier-Kastler, Emmanuel J, Ali, Liza, Peycelon, Matthieu, Mege, Diane, Demetrashvili, Zaza, Stoleriu, Mircea G, Keppler, Lena, Saier, Tim, Konrads, Christian, Tapking, Christian, Kamphues, Carsten, Bulian, Dirk R, Schmedding, Andrea, Doerner, Johannes, Gut, Anna E, Rolinger, Jens, Kirschniak, Andreas, Schröder, Lars, Reim, Daniel, Safi, Seyer, Fichter, Andreas M, Wagner, Arthur, Meyer, Bernhard, Gempt, Jens, Sablotzki, Armin R, Herzberg, Jonas, Altenburg, Manuel, Yenilmez, Ferhat, Meins, Jan, Aghwan, Louai A, Börner, Nikolaus, Keppler, Alexander M, Albertsmeier, Markus, Seyfried, Steffen, Rassweiler-Seyfried, Marie-Claire, Kriegmair, Maximilian, Kowalewski, Karl-Friedrich, Gousias, Konstantinos, Strotmann, Johanna J, Höhn, Philipp, Horn, Julian, Knipschild, Julia M, Siemen, Leonie, Luu, Andreas Minh, Horch, Raymund E, McLean, Aaron Lawson, Lindert, Judith Anne Teresa, Ziemann, Sebastian, Modabber, Ali, Winnand, Philipp, Hölzle, Frank, Sommer, Björn, Wolf, Sebastian, Shiban, Ehab, Recker, Florian, Güresir, Erdem, Randau, Thomas M, Güresir, Agi, Velten, Markus, Vilz, Tim O, Wittmann, Maria, Willis, Maria A, Glowka, Tim R, Bork, Ulrich, Hecker, Matthias, Hecker, Andreas, Reichert, Martin, Miller, Clemens, Nemeth, Marcus, Ronellenfitsch, Ulrich, Kleeff, Jorg, Lorenz, Kerstin, Kisser, Ulrich, Schneider, Rick, Seiwerth, Ingmar, Osterhoff, Georg, Linz, Valerie C, Mallmann, Michael R, Rokohl, Alexander C, Heindl, Ludwig M, Wawer Matos, Philomena A, Cursiefen, Claus, Mallmann, Christoph A, Domroese, Christian M, Königsrainer, Alfred, Yurttas, Can, Thiel, Karolin, Vahl, Julius M, Wiegering, Armin, Lock, Johan F, Heuer, Annika, Reiter, Alonja, Stangenberg, Martin, Böttcher, Arne, Kaemmerer, Daniel, Mensah, Kofi T, Gyamfi, Frank E, Opandoh, Isabella N M, Ofori, Emmanauel O, Baidoo, Ebikela I, Baidoo, Richard O, Azize, Diallo A, Appiah-Thompson, Peter, Agbeno, Evans K, Ken-Amoah, Sebastian, Rahman, Ganiyu A, Kpangkpari, Richard, Aniakwo, Luke A, Nortey, Michael, Agyapong, Meshach M, Boakye, Benedict, Mensah, Philip, Agyen-Mensah, Kwasi, Amoako-Boateng, Mabel P, Mensah, Samuel, Debrah, Sam, Yakubu, Mustapha, Adam-Zakariah, Leslie Issa, Davor, Anthony, Arthur, Joshua, Dzogbefia, Mawutor, Konney, Anna, Konney, Thomas O, Amoah, Michael, Barnor, Isaac, Issahalq, Mohammed Duah, Hoyte- Williams, Paa Ekow, Awortwi, Wilfred Sam, Hammond, Bernard, Awoonor-Williams, Ronald, Naabo, Nuhu N H, Appiah-Kubi, Adu, Adanu, Kekeli Kodjo, Clegg-Lamptey, Joe Nat A, Adae, Jefferson Owusu, Adjeso, Theophilus T K, Yahaya, Mundashiru, Ansah-Agyei, David A, Charadan, Ana Maria Simono, Labrada, Magdiel Rodriguez, Issaka, Adamu, Yabasin, Iddrisu B, Antwi, David A, Manan, Lukman, Bukari, Mohammed I S, Buunaaim, Alexis D B, Alatiiga, John Abanga, Sheriff, Mohammed, Kumi, Emmanuel O, Bonsaana, Gilbert B, Micha, Georgia, Kiriakopoulos, Nikolaos, Stroumpoulis, Konstantinos, Kalopita, Konstantina, Grypiotis, Ioannis, Psarianos, Kyriakos A, Aslanidis, Theodoros, Korkolis, Dimitris P, Fradelos, Evangelos, Arvanitaki, Alexandra, Prodromidou, Anastasia, Thomakos, Nikolaos, Theofanakis, Charalampos, Angelou, Kyveli, Haidopoulos, Dimitrios, Diakosavvas, Michail, Chardalias, Leonidas, Papaconstantinou, Ioannis, Antonakis, Pantelis T, Politis, Dimitrios, Dellaportas, Dionysios, Kontopoulou, Christina I, Memos, Nikolaos A, Gklavas, Antonios, Bramis, Konstantinos, Pappas, Panagiotis, Petropoulou, Thalia, Ioannidis, Argyrios, Ntourakis, Dimitrios, Papageorgiou, Dimitrios, Manatakis, Dimitrios K, Barkolias, Christos G, Balalis, Dimitrios, Tasis, Nikolaos P, Sidiropoulos, Theodoros A, Michalopoulos, Nikolaos V, Papadoliopoulou, Maria, Parasyris, Stavros, Danias, Nikolaos, Vassiliu, Panteleimon, Petropoulou, Zoe, Margaris, Ioannis, Kefalidid, Eirini, Papaconstantinou, Dimitrios, Paraskevas, Kosmas I, Nikova, Alexandrina S, Kalamatianos, Theodosis, Stamatis, Konstantinos, Sotiropoulou, Maria, Stylianidis, George, Kouraklis, Gregory P, Paspala, Anna, Nastos, Constantinos, Sfoungaris, Dimitrios, Valioulis, Ioannis A, Raptis, Dimitrios, Tsakiridis, Nikolaos, Tsakiridis, Konstantinos Alexandros, Arvanitakis, Konstantinos, Kalfountzos, Christos, Koukoulis, Georgios D, Bouliaris, Konstantinos, Lachanas, Vasileios A, Doudakmanis, Christos A, Chouliaras, Christos, Papadopoulos, Aristeidis, Ntalouka, Maria P, Magouliotis, Dimitrios, Fergadi, Maria, Samara, Athina A, Christodoulidis, Grigorios, Bareka, Metaxia, Athanasiou, Thanos, Arnaoutoglou, Eleni M, Hajiioannou, Jiannis, Perivoliotis, Konstantinos, Baloyiannis, Ioannis, Angelis, Fragkiskos A, Stamoulis, Konstantinos G, Symeonidis, Dimitrios, Korais, Christos, Gkrinia, Eleni, Ntziovara, Anna-Maria, Mulita, Francesk, Bouchagier, Konstantinos, Verras, Georgios I, Argentou, Maria I, Vailas, Michail, Germanos, Stylianos, Tavlas, Panagiotis, Tatsis, Dimitris, Astreidis, Ioannis T, Louizakis, Alexandros, Antoniou, Asterios, Paraskevopoulos, Konstantinos, Chrysovitsiotis, Georgios, Frountzas, Maximos, Toutouzas, Konstantinos G, Chrysovergis, Aristeidis, Potamianos, Spyridon, Kyrodimos, Efthymios, Papanikolaou, Vasileios, Theodoropoulos, George, Triantafyllou, Tania, Larentzakis, Andreas, Kimpizi, Athina-Despoina, Tsakiridis, Ioannis, Kapetanios, Georgios, Dagklis, Themistoklis, Petousis, Stamatios, Margioula-Siarkou, Chrysoula, Baili, Efstratia, Tampaki, Ekaterini C, Lostoridis, Eftychios, Avramidis, Emmanouil C, Efstathiou, Andreas P, Babis, George C, Roditis, Konstantinos, Tsiantoula, Paraskevi V, Machairas, Nikolaos, Schizas, Dimitrios, Kykalos, Stylianos, Dorovinis, Panagiotis I, Stamopoulos, Paraskevas, Charalabopoulos, Alexandros K, Liakakos, Theodore, Koziakas, Elias, Karavokyros, Ioannis, Skotsimara, Antonia, Syllaios, Athanasios, Tsourouflis, Gerasimos S, Tomara, Nefeli K, Dimas, Angelos, Apostolou, Konstantinos G, Tsouknidas, Ioannis, Samara, Evangelia, Papakonstantinou, Nikolaos A, Falara, Areti, Papavasiliou, Kyriakos, Siasios, Ioannis D, Kaselas, Christos, Anthoulakis, Christos, Tigkiropoulos, Konstantinos, Spartalis, Eleftherios, Mourmouris, Panagiotis, Tsekouras, Konstantinos, Tzelves, Lazaros, Dedemadi, Georgia, Gaitanakis, Stylianos, Marinis, Athanasios, Stamatiou, Konstantinos, Vlotinou, Pinelopi D, Xenaki, Sofia, Lasithiotakis, Konstantinos, Nikolouzakis, Taxiarchis Konstantinos, Karakosta, Agathi, Tzimas, Petros, Charatsaris, Panagiotis, Recinos, Gustavo, Vega, Marlon D, Aguilera, Maria L, Rivera, Pablo J, Sosa, Dianne A, Salazar, Tania A, Ybarra, Natalia I, Morataya, Ever E, Brolo, Estuardo J, Lowey, Andrea M, Paiz, Jose R, Wong, George KC, Ling, Samuel KK, Ng, Calvin SH, Lau, Rainbow WH, Futaba, Kaori, Toth, Dezso, Zaránd, Attila, Piros, Laszlo, Santoshi, John A, Nagar, Manoj, Shrivastava, Adesh, Ahmad, Zainab, Behera, Prateek, Gautam, Megha, Bagaria, Dinesh, Kabra, Apoorva P, Mittal, Samarth, Ranjan, Piyush, Sharma, Shilpa, Trikha, Vivek, Bagaria, Dinesh Kumar, Alam, Junaid, Goel, Prabudh, Dube, Surya Kumar, Choudhary, Narendra, Menon, Ramesh P, Seenivasagam, Rajkumar Kottayasamy, Agrawal, Abhishek, Majumdar, Kinjal S, Sharma, Pranati, Gupta, Amit, Arora, Rajnish K, Arora, Poonam, Basu, Somprakas, Huda, Farhanul, David, Lena E, Goswami, Aakansha G, Piplani, Rajat, Sultania, Mahesh, Tripathy, Sujit K, Mishra, Tushar S, Muduly, Dillip Kumar, Jena, Saubhagya Kumar, Mishra, Abhijeet, Mitra, Jayanta K, Singh, Sweta, Sahu, Ranjit Kumar, Mohanty, Chitta R, Jena, Saubhagya K, Panda, Ritesh, Boyina, Kiran Kumar, Dasukil, Saubhik, Gahlot, Nitesh, Khatri, Naren P, Kaur, Amanjot, Vishnoi, Jeewan R, Sharma, Naveen, Chugh, Ankita, singh, Mahendra, Chakraborty, Sourabh S, Rajanbabu, Anupama, Hunain, Reem, Raut, Monish S, Pandey, Diwakar, Srivastava, Raghubir, Saksena, Ajesh Raj, Garod, Mebanshanbor, Budihal, Bhargavi R, Kashyap, Shankarsai, Agarwal, Pavani B, Chhatrapati, Swati, Deshpande, Charulata, Baliarsing, Lipika Amresh, balakrishnan, Kalpana, Tanweer, Ahmed Sayeed, Haque, Parvez David, Chitresh, Sathiafrey D A, Daniel, Swati, Dutta, Rohini, Dutt, Uma Kant, Garg, Karan, Garg, Mukul, George, Christina, Ghosh, Dhruva, Gupta, Pariza, Jain, Ritu, Kalyanapu, Jeffrey A, Kaur, Savleen, Khurana, Ankita, Khurana, Sarita, Kumar, Jatin, Liddle, Dootika, Mahajan, Amit Vipan, Pawar, Pranay, Pradeep, Konda Samuel Paul, Ranadive, Reuben R, Rajkumar, Arti, Sam, Vivin Daniel, Sam, Jerrin Regi, Samuel, Habie Thomas, Samuel, Sangeetha, Sahi, Prateek, Sood, Aditya, Srivastava, Nitish, Thomas, Alen J, Thomas, Naveen J, Varkey, Jacob K, Vazhakalayil, Vigy Georgekutty, William, Rahul, Mittal, Rohin, Devarakonda, Sreekar, Riju, Jeyashanth, Thomas, Vinotha, Sivakumar, Moonish V, Sridhar, Rajeevan Philip, Jebakumar, Gilbert S, Paul, Negine, Kota, Albert A, Kumari, Pushplata, Surendran, Suraj, Suraj, Raji, Victor, Naveen Sundaram, Kathir Joyson, D R, Konduru, Vidya, Malhotra, Kashish, Rammohan, Ashwin, Rela, Mohamed, Jain, Vaibhav, Jakhetiya, Ashish, Patel, Vidhi K, Pendyala, Karuna Sree, Aggarwal, Manisha, Gupta, Shyam K, Kumar, Ashwani, Bindra, Manpreet Singh, Yadev, I, Chisthi, Meer M, Soumya, S, Anand, Sachit, Rani, Jyotsna, Sharma, Kanika, Ghosh, Indranil, Sundaraju, Shalini, Penumadu, Prasanth, Govindarajan, Krishna Kumar, Manikandan, Ramanitharan, Kavalakat, Alfie J, Phadnis, Ashish, Jadhao, Piyush, Subbarayan, Shankar, Hunain, Reem, Rodrigues, Gabriel, Ibrahim, Sufyan, Hameed, Zeeshan BM, Zachariah, Sanoop K, Madabhavi, Irappa V, Bansal, Varun V, Rajan, Shiv, Ozair, Ahmad, Chaurasia, Akhilanand, Ramakant, Pooja, Verma, Manju L, Shukla, Ayushi, Agarwal, Anjoo, Bajaj, Ankur, Jaiswal, Somil, Mishra, Brijesh, Thyavihally, Yuvaraja, Waigankar, Santosh S, Waigankar, Santosh Subhash, Hegde, Siddhi, Alexander, Philip V, Sharma, Rahul Deo, Sodhai, Vivek M, Kishore, Kunal, Vishweshwara, Ramya M, Bains, Lovenish, Kumar, Sanjeev, Malik, Akshat, Shaikh, Zahiya Hareem, Kumari, Priyanka, Thomas, Jerin J, Yadav, Sanjay Kumar, Dhurwe, Ritika, Nath, Upamanyu, Chopra, Hitesh, Kumar, Vishal, Kaman, Lileswar, Karthigeyan, Madhivanan, Tripathi, Manjul, Mohindra, Sandeep, Salunke, Pravin, Singh, Kavindra, Rangasamy, Karthick, Gopinathan, Nirmal Raj, Siroliya, Anshul, Bangal, Vidyadhar B, Gupta, Ashish, Kannaiyan, Lavanya, Kulkarni, Aditya A, Panda, Bijnya B, Mittal, Abhishek, Ghodke, Rahul J, Kale, Sachin Y, Dhar, Sanjay, Agarwal, Gaurav, Mishra, Anjali, Upadhyaya, Vijai Datta, Kumar, Basant, Jeyaraman, Madhan, Mehraj, Asif, Parray, Fazlul Q, Amin, Shivang Gaurang, Mankad, Saptak P, Thakore, Karan V, Singh, Riya, Garg, Pankaj Kumar, Majmudar, Hardil P, Sharma, Tanishq S, Chowdappa, Raghunandan Gorantlu, Maniar, Sahiba S, Thakar, Sumit, Jain, Kavitha, Patel, Tapan, Gupta, Rahul A, Aggarwal, Gaurav, Gupta, Sujoy, Agrawal, Sanjit Kumar, Sharma, Abhishek, Jain, Prateek, Ghosh, Anik, Pipara, Amrit, Pramesh, C S, Patkar, Shraddha, Patil, Vijaya Prakash, Divatia, Jigeeshu V, Puri, Ajay, Kumar, Akshay, Bhardwaj, Rohit, Mittal, Abhishek, Venkatappa, Sunil Kumar, Manangi, Mallikarjuna, Prabhu, Prashanth J, Anwar, Sumadi L, Sari, Djayanti, Tantri, Aida R, Chandra, Susilo, Manggala, Sidharta K, Auerkari, Aino N, Zahra, Raihanita, Soenarto, Ratna F, Ramlan, Andi A W, Billy, Matthew, Harzif, Achmad K, Surya, Ilham Utama, Lestari, Mayang I, Damara, Fachreza A, Aryananda, Rozi A, Aji, Yunus Kuntawi, Hadipranata, Thirza, Lie, Warren, Kembuan, Gabriele J, Cindryani, Marilaeta, Senapathi, Tjokorda Gde Agung, Ryalino, Christopher, Hosseini, Elahe, Hosseini, Alireza, Medhati, Pourya, Erfanian, Reza, Firouzifar, Mohammadreza, Anari, Mahtab Rabbani, Irani, Shirin, Rahim, Fakher, Kandevani, Naser Yousefzadeh, Kabiri, Fatemeh Sheikholeslami, Motahaver, Nima Najafian, Hosseinpoor, Masoomeh, Rajati, Mohsen, Assadi, Reza, Haqgou, Mohadeseh, Javadi, Seyed Amir, Karimian, Faramarz, Asadi, Mehdi, Alizadeh, Narges, Heidari, Mohammad, Hejazi, Seyed Fakhreddin, Alizadeh, Narges, Bazyari, Vahid, Ahmadi, Sayedali, Yusefi, Hossein, Attar, Mojtaba KA, Zanjani, Leila Oryadi, Nabian, Mohammad Hossein, Yahyazadeh, Seyed Reza, Manesh, Hassan Fatemi, Sotudeh, Mohadese, Akhavizadegan, Hamed, Shafiei, Seyyed Hossein, Aldawoody, Hogir I, Almusawi, Ahmed A, Al-Isawi, Ali, Al-Hajjaj, Ahmed Basim Abed, Zwain, Yasir A, Alwash, Mohammed J, Hadi, Najah R, Maala, Rasool, Adil, Aeshah Anwar, Hashim, Hashim Talib, Al-Salihi, Naseem W, Al-hasani, Fahad Majid Yaseen, Rashed, Pakhshan A, Muhamed, Pakhshan A, Hilmi, Ahmed A, Akhtyare, Mohammed Musa A, Hashim, Hashim T, Hussein, Rand A, Aljohmani, Lylas, Crotty, Fiona E, Elliott, Jessie A, Javadpour, Mohsen, Davis, Niall F, Ryan, James PC, Aremu, Muyiwa, O'Brien, Stephen J, Wong, Benjamin Ngie Xiong, Hsiao, Michelle Min, Andrews, Emmet, Pretorius, Jacques, Azeem, Imran, Ikele, Hilary, McCarthy, Claire M, Salameh, Fadi-Tamas, O'Connor, Donal B, O'Connor, Clare, Sheahan, Patrick, Barry, Conor P, Kavanagh, Fergal G, Callanan, Deirdre, James, Danielle L, Clancy, Cillian, Croghan, Stefanie M, Aherne, Thomas M, Kiernan, Aoife, Owens, Patrick W, Creavin, Ben, Mekki, Hassan, Walsh, Stewart R, Carroll, Paul A, Oh, Ke En, Lowery, Aoife J, Bala, Miklosh, Shussman, Noam, Demma, Jonathan Abraham, Marom, Gad, Fishman, Yuri, Zmora, Osnat, Kalmovich, Limor Muallem, Horesh, Nir, Anteby, Roi, Papa, Mario V, Argenio, Giulio, Sozzi, Giulio, Amatucci, Chiara, Segalini, Edoardo, Pesenti, Giovanni, Giani, Alessandro, Mazzola, Michele, Lombardi, Pietro Maria, Saibene, Alberto M, Mariani, Nicoló M, Zanin, Luca, Andreuccetti, Jacopo, Ferrari, Federico, Baiocchi, Gian Luca, Frontali, Alice, Granieri, Stefano, Cotsoglou, Christian, Scarpa, Marco, Colasanti, Roberto, Schiavone, Donatella, Castaldi, Antonio, Antropoli, Carmine, Colò, Gabriele, Fiume, Irene, Poillucci, Gaetano, Fortuna, Laura, Locatello, Luca G, Gallo, Oreste, Maggiore, Giandomenico, Bottari, Andrea, Bruno, Chiara, Barbato, Giuseppe, Di Bella, Annamaria, Taddei, Antonio, De Pastena, Matteo, Campagnaro, Tommaso, Malleo, Giuseppe, Paiella, Salvatore, Balduzzi, Alberto, Capozzi, Vito Andrea, Carretta, Alessandro, Bertolini, Giacomo, Dalmonte, Giorgio, Giuffrida, Mario, Andriola, Valeria, Martines, Gennaro, Picciariello, Arcangelo, Pattacini, Gianmaria Casoni, Di Bartolomeo, Mattia, Anesi, Alexandre, Nikaj, Herald, Gentilli, Sergio, Reitano, Elisa, Fiacchini, Giacomo, Di Franco, Gregorio, Morelli, Luca, Andreani, Lorenzo, Tartaglia, Dario, Balestri, Riccardo, Coccolini, Federico, Chiarugi, Massimo, Puccini, Marco, Fusario, Daniele, Samorani, Osvaldo Carpineto, Marano, Luigi, Carbone, Ludovico, Roviello, Franco, Restaino, Valeria, Pesce, Anna Lisa, Resca, Luca, Piccioni, Stefania Angela, Veroux, Massimiliano, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Cianci, Antonio, Morini, Andrea, Zizzo, Maurizio, Mastrofilippo, Valentina, Mandato, Vincenzo Dario, Aguzzoli, Lorenzo, Sarnari, Jlenia, Nita, Gabriela E, Fabbri, Nicolò, Rubbini, Michele, Tutino, Roberta, Podda, Mauro, Canu, Gian Luigi, Peiretti, Enrico, Trungu, Sokol, D'Oria, Mario, Lauretta, Andrea, Marro, Matteo, Guerrera, Francesco, Santarelli, Mauro, Salizzoni, Stefano, Iocca, Oreste, Di Maio, Pasquale, Perra, Teresa, Porcu, Alberto, Scanu, Antonio M, Pirozzolo, Giovanni, Toia, Francesca, Dinoto, Ettore, Cammarata, Emanuele, Franza, Mara, Rosatti, Fernando, Cipolla, Calogero, Di Grazia, Natalia, Milia, Walter R, Pecoraro, Felice, Virgilio, Edoardo, Barberis, Andrea, Bàmbina, Fabrizio, Lavalle, Laura, Sinibaldi, Giovanni, Licari, Leo, Tropeano, Francesca P, Luglio, Gaetano, Pagano, Gianluca, Tropeano, Francesca Paola, Peltrini, Roberto, Nuzzo, Maria Michela Di, Bracale, Umberto, Indini, Alice, Bissacco, Daniele, Domanin, Maurizio, Torretta, Sara, Bogani, Giorgio, Martinelli, Fabio, Sala, Laura, Cortinovis, Umberto, Zingarello, Valeria, Bertolina, Francesca, Hilal, Moh'd Abu, Fransvea, Pietro, Marra, Angelo A, Rosa, Fausto, Litta, Francesco, Ratto, Carlo, Parello, Angelo, Tedesco, Silvia, Ferracci, Federica, Pitoni, Sara, D'Archi, Sabatino, Franceschini, Gianluca, Scardina, Lorenzo, Gravante, Gianpiero, Conti, Luigi, Baldini, Edoardo, Maniscalco, Pietro, Ciatti, Corrado, Spriano, Giuseppe, Mercante, Giuseppe, Gaino, Francesca, Milana, Flavio, Spinelli, Antonino, Ferreli, Fabio, De Virgilio, Armando, Di Bari, Matteo, Aquilino, Fabrizio, Marino, Fabio, Pellini, Raul, Campo, Flaminia, Moretto, Silvia, Mazzola, Francesco, Petruzzi, Gerardo, Mastroianni, Riccardo, Simone, Giuseppe, Rottoli, Matteo, Russo, Iris S, Raimondo, Diego, Fernandez, Ignacio J, Raffone, Antonio, Bertoglio, Pietro, Ravaioli, Matteo, Germinario, Giuliana, Bernante, Paolo, Casadio, Paolo, Seracchioli, Renato, Droghetti, Matteo, Schiavina, Riccardo, Ricotta, Francesco, Tarsitano, Achille, Arena, Alessandro, Della Gatta, Anna Nunzia, Violante, Tommaso, Pellegrini, Alice, Bolognesi, Federico, Solli, Piergiorgio, Ricciardi, Sara, Cipolli, Alessandro, Maletta, Manuela, La Porta, Marilina, Lauretta, Maria Paola, Melotti, Rita M, Daddi, Niccolò, Parri, Sergio Nicola Forti, Garelli, Elena, Perrone, Anna M, Lombardi, Raffaele, Pinto, Valentina, Pignatti, Marco, Tonini, Valeria, Copelli, Chiara, Giordano, Antonio Nicola, Palai, Vincenzo, Aspide, Raffaele, La Corte, Emanuele, Lucchini, Stefano, Castagnini, Francesco, Pardo, Francesco, Di Liddo, Michele, Caternicchia, Filippo, Donati, Danilo, Cavalieri, Bruno, Frisoni, Tommaso, Rotini, Marco, Scabini, Stefano, Vagge, Aldo, Desideri, Lorenzo Ferro, Barra, Fabio, Sparavigna, Marco, Fregatti, Piero, Luzzi, Andrea-Pierre, Costantini, Sergio, Ferrero, Simone, Gustavino, Claudio, Paratore, Marco, Perrone, Umberto, Centurioni, Maria Grazia, Alessandri, Franco, Ferraiolo, Antonella, Rosato, Francesco Paolo, Ball, Lorenzo, Ascari, Francesca, Barugola, Giuliano, Lovece, Andrea, Milito, Pamela, Siboni, Stefano, Bonavina, Luigi, Aiolfi, Alberto, Bona, Davide, Micheletto, Giancarlo, Bertolaccini, Luca, Sedda, Giulia, Spaggiari, Lorenzo, Tagliabue, Marta, De Berardinis, Rita, Pietrobon, Giacomo, Chu, Francesco, reAnsarin, Mohssen, Garbi, Annalisa, Patrone, Renato, Belli, Andrea, Cianci, Pasquale, Raimondo, Ivano, Ferrero, Annamaria, Pacilio, Carlo Alberto, Bocchino, Antonio, Solaini, Leonardo, D'Acapito, Fabrizio, Di Stefano, Barbara, Corso, Ruggero M, Pata, Francesco, Vitale, Mariarosaria, Rotunno, Giuseppe, Lenzi, Riccardo, Migliorino, Ernesto, Grossi, Ugo, Novello, Simone, Romano, Maurizio, Rossi, Serena, Zanus, Giacomo, Epifani, Angelo G, Broglia, Alessandro, Santoliquido, Matteo, Clementi, Marco, Marafante, Chiara, Carrano, Francesco Maria, Patrone, Renato, Fleres, Francesco, Clarizia, Guglielmo, Coretti, Guido, Ferrario, Luca, Guerci, Claudio, Maffioli, Anna, D'Andrea, Marcello, Zanini, Nicola, Bertelli, Riccardo, Vallicelli, Carlo, Catena, Fausto, Prucher, Gian Marco, Conti, Alfredo, Moretto, Gianluigi, Inama, Marco, Grivon, Manuela, Sambucci, Daniele, Pirola, Giacomo M, Gubbiotti, Marilena, Sagnotta, Andrea, Ornaghi, Sara, Fruscio, Robert, Tamini, Nicolò, Ceresoli, Marco, Gianotti, Luca, Masciello, Fabrizio, Nelli, Tommaso, Canonico, Giuseppe, Anastasi, Alessandro, Malerba, Michele, Abate, Emmanuele, Lizzi, Vincenzo, Sarni, Antonio L, Tartaglia, Nicola, Montagna, Marco, D'Ugo, Stefano, Depalma, Norma, Spampinato, Marcello, Pizzini, Paolo, Magnone, Stefano, Migliore, Marcello, Volpicelli, Alessio, Gioco, Rossella, Russo, Giorgio Ivan, Bozzani, Antonio, Cobianchi, Lorenzo, Calabretto, Francesca, Pinotti, Enrico, Barone, Mirko, Campanelli, Michela, Bagaglini, Giulia, Siragusa, Leandro, Orecchia, Luca, Franceschilli, Marzia, Angelico, Roberta, Sensi, Bruno, Manzia, Tommaso M, Petagna, Lorenzo, Bacchiocchi, Giulia, Sica, Giuseppe S, Lapolla, Pierfrancesco, Picchetto, Andrea, Bruzzaniti, Placido, Marruzzo, Giovanni, Sterpetti, Antonio V, Mingoli, Andrea, Sapienza, Paolo, Scafa, Anthony Kevin, Zancana, Giuseppa, Brachini, Gioia, Ribuffo, Diego, Cirillo, Bruno, Meneghini, Simona, Cicerchia, Pierfranco M, Zambon, Martina, D'Andrea, Vito, D'Amico, Alessia, Familiari, Pietro, Cassoni, Andrea, Pucci, Resi, De Felice, Francesca, Pascarella, Giuseppe, Strumia, Alessandro, Coppola, Alessandro, Zampogna, Biagio, Papalia, Rocco, Capolupo, Gabriella T, Caricato, Marco, Nenna, Antonio, Dominici, Carmelo, Caffo, Maria, Badessi, Giorgio, Mazzeo, Carmelo, Caruso, Gerardo, Bellio, Gabriele, Guaitoli, Eleonora, Rimonda, Roberto, Fusini, Federico, Giacometti, Marco, Baldi, Caterina, Ferrara, Francesco, Chessa, Antonella, Accarino, Giulio, Monteleone, Michela, Riva, Carlo, Balconi, Arianna, Markovic, Marko, Barone, Gisella, Locatelli, Andrea, Olmetti, Simone, Costanzi, Andrea, Uccelli, Matteo, Galleano, Raffaele, Balla, Andrea, De Carlo, Antonio, Ceretti, Andrea Pisani, Bertoglio, Luca, Grandi, Alessandro, Apruzzi, Luca, Melloni, Andrea, Spartalis, Michael, Spina, Alfio, De Nardi, Paola, Bonavina, Giulia, Candiani, Massimo, Piloni, Martina, Nocera, Gianluca, Gagliardi, Filippo, Turi, Stefano, De Nunzio, Cosimo, Petrucciani, Niccolo, Fiorelli, Silvia, Laracca, Giovanni G, Menna, Cecilia, Lisi, Giorgio, Brolese, Alberto, Ciarleglio, Francesco A, Sasia, Diego, Giraudo, Giorgio, Testa, Valentina, Giuffrida, Maria Carmela, Chiarpenello, Roberto, Dalmasso, Ettore, Cianflocca, Desiree, Calini, Giacomo, Cillara, Nicola, Armatura, Giulia, Turati, Luca, Pellino, Gianluca, Menna, Maria Paola, Iovino, Claudio, Rossi, Settimio, Simonelli, Francesca, Baccellieri, Domenico, Candiani, Massimo, Gozzini, Lorenzo, Elmore, Ugo, Rosati, Riccardo, Gallo, Gaetano, Giannaccare, Giuseppe, Cristofaro, Maria G, Barca, Ida, Carnevali, Adriano, Consorti, Giuseppe, Laganà, Antonio Simone, Pontini, Alex, Salvador, Renato, Di Marzo, Francesco, Turri, Giulia, Saito, Junichi, Kochiyama, Tsukasa, Satoi, Sohei, Hashimoto, Daisuke, Yoshimatsu, Kazuhiko, Namikawa, Tsutomu, Kuriyama, Akira, Sunami, Eiji, Takeda, aChikashi, Shiota, Masaki, Toyama, Satoshi, Ishitobi, Makoto, Kawasaki, Yosuke, Kawaguchi, Masahiko, Ida, Mitsuru, Iwasaki, Masae, Mase, Hiroshi, Fujimoto, Yuki, Chaki, Tomohiro, Tachibana, Shunsuke, Kazuma, Satoshi, Kuroda, Naoto, Matsuki, Yuka, Kamizato, Kota, Omari, Rand Y, Salim, Mohammad Ahmad Jamil Es, Alwarawrah, Zaid, AAbdulrahmanlarood, Salameh A, Alnaser, Adnan R, Alhusseini, Radi Tofaha, Qasem, Abdulrahman G, Eid, Ahmad M, Theab, Mohammad A, Ghayada, Ibrahim, Guboug, Ali, Alqedrh, Mohannad Fayiz, Al-banna, Mohammed E, Abuleil, Amro, Asassfeh, Yaqin Mahmoud, ali, Zaid Mohammed Al-sheikh, Eid, Ahmad Ayman, AbuSalah, Reem G, Hijazeen, Raid George, Awadi, Sajeda, Mansour, Omar S, Khamees, Almu'atasim, Alrayes, Bourhan, Hassan, Mohammad, Qandeel, Mahmoud W M, Ibrahim, Zainab O, Salah, Mohammad Maher Salah, Alnatour, Hazem Zuhair, Saleh, Ma'moun Helmi Suleiman, Suradi, Haya H, Abu Serhan, Hashem A, Abu Za'nouneh, Faris Jamal, Alheji, Hazim R, Al-Shami, Khayry, Mousa, Ala'a Al-deen T, Bsisu, Isam K, Bsisu, Rasha, Abuzenah, Mohammad I A, Kalaji, Zeina H, Jabaiti, Samir, Omeish, Haya A, Almuhtaseb, Aseel Y, Abuleil, Amro M, Theab, Reem A, Sheyyab, Anagheem A, Hamouri, Shadi, Ababneh, Hazim S, Amarin, Zouhair, Bahhour, Mohammad Yasin, Abu-Mehsen, Marah K, Al-howthi, Mohammed Abdullah, Wafi, Omar S S, Sawadi, Taher Rashed Mohammed, Albustami, Iyad S, Masadeh, Maen O, Al Khassawneh, Ahmad, Amarin, Justin Z, Irshaidat, Sara S, Abou Chaar, Mohamad K, Zaghlol, Louay Y, Mansour, Razan, Shahait, Mohammed, Qandeel, Haitham, Abd Almonem, B, Hawasly, Lubna, Alsabbagh, Ghalia, Al-Dabaa, Tawfik Mohammed, Amer, Qaed Mashhour Bani, Abu-Ismail, Luai, Shaout, Dua'a M, Abu-shadouf, Tariq H, Bolatbekova, Raikhan, Issayev, Nadir, Kulimbet, Mukhtar B, Kiyabayev, Almaz M, Ospanova, Dinara, Zhumatayev, Dauren, Baimakhanov, Abylai, Fakhradiyev, Ildar, Tanabayeva, Shynar, Saliev, Timur, Kaidarova, Dilyara, Cheserem, Beverly, Hamdun, Intisar H S, Munubi, Aziz Z, Siboe, Mark M W, Wachera, Samuel Wanjara, Parker, Robert K, Mwachiro, Michael M, Mwangi, Victor Pendaeli, Jafar, Yaqoub M, Al-Shaiji, Tariq F, PÄolkins, Andrejs, Apse, Ingus A, Sheth, Hemant D, Pāvulāns, Jānis, Karout, Samar, Farfour, Imadeddine Ahmad, Safar, Ali O, Lichaa, Anthony, Ismail, Salim H, Kassab, Mohamad B, Abou-Abbass, Hussein, Awad, Rabih F, El Assaad, Hadi, Serhan, Fatima Ghazi, Karout, Lina, Chowdhary, Anisa, Itani, Rania, Abu Hamrah, Ali A A, Bellah, Almoataz, Algatanesh, Nassib S, Duwebi, Mousab A, Alkouba, Esraa T, Algehani, Hala M, Alsharif, Monther, Al-maadany, Faraj S, Elkhafeefi, Fatimah S, Buimsaedah, Ahmad M, Ghazal, Sarah M, Amnaina, Mohamed G, Yagoub, Ghozlan Y, yahia, Hana Ramadan bin, Bareig, Elham Hussin, BenHamida, Bahaeddin, Alkimeeshi, Nayrouz, Marwan, Malak, Muhammed, Nawal Aldokali, Benamer, Eman M, Othman, Rema H, Momen, Ahmed A, Ayad, Kusay A, Aldokali, Nawal, Mohammed, Alsnosy Abdullah Khalefa, Sanousi, Enas F, Aboubakr, Saed J, Aboubakr, Islam F, Alttaira, Amal, Benatiga, Sara A, Alteerah, Ilham A, Aldressi, Wafa, Elhwety, Marwa O, Kalifa, Mohamed Fathi, Glessa, Maram A, Abubaker, Taha, Shembesh, Hassan A, Alansari, Arowa, Alkaseek, Akram M, Abusannuga, Malek Mohamed, Alawami, Mohammed A, Elhajdawe, Fras Ammar, Benamwor, Aihab Salem, Aween, Husayn M, Kriem, Eslam, Al Islam Benjouira, Rayet, Shagour, Sana Moussa, Ali, Hajar Alamin, Awrayit, Ahmed I, Matoug, Salmin Ibrahim, Abdesalam, Rema Ibrahim, Ouakouak, Ikhlas M, Aldarraji, Ali H, Elmahdi, Ameerah Faraj, Mohamed, Zinelabedin, Khan, Samera M, Gerwash, Ahmed A, Aboubeirah, Mohammed Khayri, Drera, Nosaiba Jalal, Sinan, Marwa A, Abujrad, Ekram Abdulhamid, Biala, Marwa, Gidiem, Doaa A, Aljamal, Sarah A, Hamuda, Esmail M, Manhus, Hussamuddin Abusaa, Binnawara, Muhannud Hassan, Elhadi, Muhammed, Msherghi, Ahmed A, Ajala, Mohamed, Shetty, Nadia D, Kanna, Sanad S, Said, Mohamed H, Elghazal, Mohamed M, Alwarfalli, Moaz Mustafa, Alharari, Mohamed A, Etayeb, Eslam, Abozid, Anwaar M, Rdadi, Kariman, Alferis, Tariq, Ellojli, Ibrahim A, Abuhallalah, Muad F, Jahan, Alhadi M, Alhadi, Abdulmueti, dra, Mohammed Abdunaser, Abdalhamed, Nadia M, Saleh, Ismail A, Albakosh, Bashir Abobaker, Hasan, Najat Ben, Bin Wali, Salema S, Hasan, Hayat Ben, Yahya, Hana B, Ambrazevicius, Marijus, Samalavicius, Narimantas E, Venskutonis, Donatas, Dauksa, Albertas, Dambrauskas, Zilvinas, Gudaityte, Rita, Dulskas, Audrius, Januška, Gediminas, Strupas, Kestutis, Poskus, Tomas, Gulla, Aiste, Caruana, Rebecca, Patel, Parth K, Ong, Ernest CW, Ahmed, Sarfraz, Yusoff, Ahmad Ramzi, Abdullah, Bahiyah, Miswan, Mohd Fairudz Mohd, Wong, Sui-Weng, Jailani, Ruhi Fadzlyana, Hakim, Nor A, Tai, Hizami Amin, Yee, Lee Fei, Yahaya, Ahmad S, Fathi, Nik Q, Voon, Kelvin, Hung, Wei Pin, Noor, Ruzaimie, Salleh, Syahrul Anuar, Ismail, Muhamad Izwan, Huei, Tan Jih, Ramely, Rosnelifaizur bin, Zakaria, Andee Dzulkarnaen, Mohamad, Ikhwan Sani, Hashim, Mohd Nizam Md, MahboobAli, Mohamed Shafi, Ab Rahman, Norhafiza, Othman, Ahmad Faidzal, Sarif, Mat Salleh, Chai, Feng Yih, Liang, Lim See, Rahim, Razrim, Subramaniam, Sentilnathan, Mah, Jin-Jiun, Hayati, Firdaus, Ibrahim, Aini Fahriza, Kuan, Yew Chor, Mahendran, Hans A, Nazimi, Abd Jabar, Imran, Farrah Hani, Ramli, Roszalina, Din, Norshamsiah M, Fai, Tang Seng, Nabil, Syed, Bastion, Mae-Lynn C, Chik, Ian, Nah, Shireen A, Krishnasamy, Sivakumar, Roslani, April C, Koh, Peng Soon, Teoh, Li Ying, See, Mee-Hoong, Wong, WeiJin, Liew, Yew Toong, Fadzli, Ahmad N, Baig, Atif Amin, Chircop, Francesca, Chircop, Kurt Lee, Psaila, Josephine, Reyes, Guillermo Yanowsky-, Orozco-Perez, Jaime, Santana-Ortiz, Rafael, Peña-Balboa, Laura G, Trujillo-Ponce, Sergio A, Miranda, Raúl A, Lara, Luis A, Beristain-Hernandez, Jose-Luis, Cisneros, Juan Roberto Torres, López, Sonia, Arceo-Olaiz, Ricardo, Anaya, Ernesto, Ochoa C, Francisco J, Gutierreaz-Sougarret, Bernardo J, Soulé-Martínez, Christian E, Lupián-Angulo, Arianne I, Sanchez-Valdivieso, Enrique A, Noguez-Castillo, Mónica, Mellado, Dorihela Herappe, Núñez González, Roberto A, Ortega Jiménez, José A, Pérez-Navarro, José V, González-Ojeda, Alejandro, Barbosa-Camacho, Francisco J, Flores-Becerril, Paola, Esparza-Estrada, Isaac, Guzman-Barba, Jose A, Reyes-Elizalde, Emilio A, Bernal-Hernandez, Aldo, Ibarrola-Peña, Juan C, Moran-Galaviz, Ruben E, Pacheco-Vallejo, Luis R, Guzmán-Ramírez, Bertha G, Castillo-Cardiel, Guadalupe, RRamirez-González, Luis, Govea-Camacho, Luis H, Ramos-De La Medina, Antonio, Trejo-Avila, Mario, Sosa Duran, Erik E, Pinto Angulo, Victor M, Visag-Castillo, Victor, Soto-Carvajal, Angélica A, Izaguirre, Aldo F, Martinez-Mier, Gustavo, Miguelena, Luis Hernández, Hernandez, Edgard Efren Lozada, García, Francisco Cesar Becerra, Melchor-Ruan, Javier, Salgado-Nesme, Noel, Garay-Lechuga, Daniel, Vergara-Fernandez, Omar, Ambriz-González, Gabriela, Peón, Alberto N, Durán-Méndez, Alejandro, Ortega, Eduardo N, Pérez, Daniela, Salgado-Garza, Gustavo, Rodriguez, H Alejandro, Rojnoveanu, Gheorghe A, Vozian, Marin G, Gurghis, Radu I, Caraja, Petru, Erdene, Sarnai, Sandag, Erdene, Orsoo, Soyombo, Orgoi, Sergelen, Kinany, Asmae, Bakali, Youness, Aziz, Slaoui, Bijou, Walid, Guechati, Hasnae, Boualila, Lina, Othmane, Bouanani, Sefrioui, Taha I, El Azzouzi, Rajaa B, Oudrhiri, Mohammed Yassaad, Bechri, Hajar, Elkoundi, Abdelghafour, Souadka, Amine, Benkabbou, Amine, Majbar, Mohammed Anass, ElBahaoui, Nezha, Mohsine, Raouf, El Mohafide, Ghita, El Ahmadi, Brahim, Ghannam, Abdelilah, Belkhadir, Zakaria Houssain, Khatri, Anadi, Tripathi, Prashant, Bhusal, Subarna, Munakomi, Sunil, Bloemers, Frank W, Bakx, Roel, van Berge Henegouwen, Mark I, Gisbertz, Suzanne S, Goudsmit, Ben FJ, Leclercq, Wouter KG, Spaans, Louisa N, Harlaar, Niels J, Kruijff, Schelto, Sansoni, Gabriela A, Harlianto, Netanja I, Konsten, Joop L, den Boer, Frank C, Dekker, Nicole AM, Schweitzer, Donald, Chu, Michael JJ, Allen, Natalie, Wang, Jim Hsu-Shun, Lyons, Oliver, Carey, Fiona J, Wright, Deborah M, Lightfoot, Nicholas J, Oliver, Tiffany C, Wen, Daniel D, Singh, Vidit, Kieser, David C, Wilson, Nichola C, Varghese, Chris, Fagan, Paul V B, McGuinness, Matthew James, Harmston, Christopher, Gómez, Néstor Javier Pavón, Adamou, Harissou, Kirfi, Abdullahi M, Abdull, Dr Mohammed M, Adamu, Auwal, Liman, Haruna U, Umar, Bello Shahir, Adeyeye, Ademola, Ifoto, Oghenekaro S, Akinmade, Akinola, Musa, Keffi Mubarak, Oyelowo, Nasir, Tolani, Musliu Adetola, Sholadoye, Tunde Talib, Yakubu, Alfa, Ajagha, Okeoghene M, Fidelis, Lovely, Ogunsua, Oluseyi O, Daniyan, Muhammad, Ahmad, Jameel I, Garzali, Ibrahim U, Kurawa, Musbahu S, Mohammad, Mohammad A, Hassan, Sadiq, Muhammad, Saminu, Abdullah, Lawal B, Takai, Idris U, Aliyu, Mohammed S, Habib, Saudat G, Ahmad, Misbahu H, Aji, Sani A, Ajiya, Abdulrazak, Adumah, Collins C, Salami, Omotayo F, Mohammed-Durosinlorun, Amina, Kache, Stephen Akau, Taingson, Matthew C, Adze, Joel Amwe, Abiola, Olajide O, Olaogun, Julius G, Akinruli, Oluwatosin A, Abolanle, Philip O, Eze, Emmanuel I, Sale, Danjuma, Alayande, Barnabas T, Ekwunife, Christopher N, Okereke, Chukwuma E, Ekpemiro, Chinwendum U, Afolabi, Akinwale Ibrahim, Olubayo, Oluniyi O, Ige, Oluwasuyi E, Adebayo, Olaolu O, Adebanjo, Ademola T, Nwahiri, Ngozi, Okunlola, Abiodun Idowu, Babalola, Olakunle F, Ojo, Owolabi D, Dele, Ojo D, Adebara, Idowu, Orewole, Tesleem O, Abiola, Paul O, Henry, Abiyere O, Chukwu, Ifeanyichukwu M, Idowu, Olufemi E, Njokanma, Iloba G, Ayodele, Olabamidele A, Williams, Omolara M, Faboya, Omolara M, Olajide, Thomas Olagboyega, Salawu, Ahmed A, Ugwu, Aloy Okechukwu, Seyi-Olajide, Justina O, Ladipo-Ajayi, Oluwaseun A, Belie, Orimisan, Rabiu, Taopheeq B, Olaomi, Oluwole Olayemi, Okoye, Onyedika G, Arojuraye, Soliudeen A, Jones, Gbenga E, Ekwunife, Okechukwu H, Egwuonwu, Ochonma A, Emegoakor, Chiemelu D, Modekwe, Victor I, Ojo, Olugbenga O, Balogun, Simon A, Ajekwu, Temitope O, Omon, Henry E, Anele, Christopher O, Adesunkanmi, Abdulhafiz O, Ijarotimi, Omotade A, Komolafe, Edward O, Ajekwu, Samuel C, Adisa, Adewale O, Wuraola, Funmilola O, Olugbami, Adebayo M, Aderounmu, Adewale A, Allen, Olubukola O, Adeleke, Akeem A, Lawal, Adedayo O, Nana, Fayowole O, Fadare, Oluwatoyin O, Maigana, Mohammed, Ubom, Akaninyene E, Mohammed, Tajudeen O, Adeleye, Amos O, Baiyewu, Lateef A, Balogun, James A, Omigbodun, Akinyinka O, Aladelusi, Timothy O, Ugwu, Ebere O, Ogundoyin, Oluwole A, Michael, Afieharo I, Ogunrewo, Tolulope O, Ojediran, Oluwabukade T, Egbuchulem, Ifeanyichukwu K, Okoh, Nelson U, Ogundoyin, Olakayode O, Odeyemi, Olubunmi E, Eyitayo, James O, Olawoye, Olayinka A, Lawal, Taiwo A, Akinmoju, Olumide D, Abdus-Salam, Rukiyat A, Ezeme, Constantine, Williams, Shekinah Y, Oladiran, Ajibola B, Oladejo, Samuel T, Obadan, Izegaegbe O, Nwachukwu, Goodluck A, Ademola, Samuel A, Ulasi, Ikechukwu B, Ikwu, Chiedozie K A, Lawal, Folake B, Okere, Oghenekevwe E, Afolabi, Adefemi O, Abayomi, Olukayode O, Gbolahan, Olalere O, Fakoya, Adegbolahan J, Adeyemo, Adebolajo A, Ayodeji, Ogunkeyede S, Abdullahi, Habiba I, Sani, Samuel A, Garba, Stephen E, Sulaiman, Bilal, Olori, Samson, Akaba, Godwin O, Egbor, Esezobor P, Odai, Emeka D, Ezeanochie, Michael C, Irowa, Omorodion O, Agbonrofo, Peter I, Okhakhu, Amina L, Onyeagwara, Ngozi C, Nwashilli, Nnamdi J, Ezenwa, Ekene V, Echieh, Chidiebere Peter, Raji, Hadijat O, Bello, Jibril O, Nasir, Abdulrasheed A, Abdur-Rahman, Lukman O, Popoola, Ademola A, Kumolalo, Felix O, Ezomike, Uchechukwu O, Onyemaechi, Ndubuisi O, Akanni, Bolaji A, Enemuo, Vincent Chidi, Nwafor, Ikechukwu A, Nnadozie, Ugochukwu U, Ugwu, Aloy Okechukwu, Ogu, Rosemary N, Ikimalo, John I, Okonta, Kelechi E, Buowari, Dabota Y, Augestad, Knut Magne, Banipal, Gurpreet Singh, Massoud, John, Al Ismaili, Amur, Al Balushi, Zainab Nasser, Alward, Mustafa M, Al Sabti, Hilal A, Al-Mujaini, Abdullah S, Ghosh, Dhruva Nath, Ali, Farman, Dawud, Bashar A, AlSibai, Sareyah, Martins, Russell S, Vohra, Lubna M, Muhammad, Shoaib, Sarfraz, Azza, Siddiqui, M Tayyab H, Pervaiz, Arsalan, Abidi, Sakina S, Thada, Pawan K, Aleem, Sidra, Choudhry, Saud J, Yaqoob, Eesha, Kerawala, Asad A, Chaudhary, Muhammad H, Chaudhary, Muhmmad A, Ali, Mujahid Z, Mazhar, Imran, Khalid, Omer B, Kausar, Nabila, Khokhar, Muhammad I, Nawaz, Allah, Malik, Muhammad U, Butt, Adam U A, Rehman, Abdur, Ghufran, Muhammad A, Rai, Lajpat, Qureshi, Sajida, Saeed, Summaya, Maqsood, Aafia, Samo, Khursheed A, Sarfraz, Zouina, Jamil, Manahil, Javed, Saad, Khan, Tayyab M, Khan, Muhammad S, Khalid, Areeb, Khan, Shahzad A, Javed, Ayesha, Khan, Muhammad M, Zaki, Faiqa, Malik, Sajid, Manzoor, Shahneela, Anwer, Mariyah, Mabood, Waleed, Aaghar, Mohammad S, Mehmood, Qasim, Waqar, Hassan, Janjua, Azwa, Manzoor, Sobia, Khan, Ehsan A, Murtaza, Sajeela, Anjum, Muhammad A, Farooq, Muhammad S, Munir, Muhammad K, Akhtar, Muhammad S, Bukhari, Syed I, Rehman, Shams U, Shah, Faaiz A, Malik, Awais A, Syed, Shamail A, Saqib, Imad-ud-din, Mushtaq, Hassan, Mahesar, Kashif Z, Tariq, Muhammad, Ali, Aun, Sayyed, Raza, Ahmad, Asrar, Maria, Noor U H, Iqbal, Ayesha, Rehman, Abdul, Qureshi, Ahmad U, Butt, Usman I, Islam, Adeel, Danish, Rana, Waqas, Ammar, Javed, Munaza A, Zahra, Dur-e, Ali, Saqib, Majid, Haroon J, Irshad, Ahsan, Naseer, Muhammad A, Nasir, Irfan I, Bangash, Ali H, Altaf, Humera N, Bukhari, Syed M A, Ali, Jehangir F, Asif, Muhammad, Niazi, Samiullah K, Tahir, Warda, Aziz, Muhammad U, Talat, Nabila, Khaliq, Tanwir, Irshad, Abeer, Ahsan, Muhammad F, Waqar, Shahzad H, Mustafa, Fatima, Banat, Mohamad A, Albaradiyyah, Baha G, Shahin, Farah Bilal, Abu-Arish, Hamdoon, Misk, Rami A, Titi, Rawand, Abuzaina, Khalil N, Awad, Bashar Y, Awad, Mohammad Y, Aljunaidi, Roa'a M, Hasani, Asala Khalil, Pujee, Bushra K, Jibreel, Malak Y, Abusabha, Orwa M, Abusabha, Saja E, Eid, Haneen I, Wishah, Abdalqader A K, AbuJlambo, Abdallah Ibrahim, Darweesh, Mahran Daowd, Shehada, Ameer kh, Altallaa, Mohammed I, Hilles, Momin M Y, Alwali, Abdallah M, Elejla, Sewar A, Aljuba, Ayat A, Manasra, Mahmood R, Awad, Hadeel I, Karkour, Sajeda y, Shawabka, Amal M, AbuIrayyeh, Bara M, Mousa, Omar A, Amro, Sarah, Aburayyan, Fatima I, Alzughayyar, Tareq Z, Zalloum, Jihad S, Abu-Arish, Hamdoon J, Hussien-Al-Ali, Fida K, Asafrah, Tamer S, Jabari, Sami D, Heih, Omar Q, Muhtaseb, Rahaf Haitham, Jibreel, Malak Y, Hasani, Asala K, Alsarahna, Omar Khaled, Alwali, Abdelrahman M, Albelbeisi, Ahmed Hassan, Abu Jayyab, Mustafa A, Salloum, Omar H, Yangüez, Adalberto, Beron, Reinaldo Isaacs, Hurtado, Mariela G, Gomez, Hugo A, Corrales, Fanny, Matsumura, Kiichiro, Arévalo, Alejandro, Martínez, María José, Pedrozo, Brayan D, Sánchez, Rosa I, Añazco, Dulce, Chavez, Cristian, Sisa, Cesar G, Segovia-Lohse, Herald R, Segovia-Lohse, Helmut A, Santacruz, Eduardo R, Leiva, Alejandro G, Cano, Cesar A, Lozano, Christian M, Borda-Luque, Giuliano, Torres-Gomez, Lucero, Arones, Ricardo, Cubas, W Samir, Shiraishi-Zapata, Carlos J, Mendiola, Gian C, Sánchez, Joel J, Berrospi, Francisco E, Falcon, Glenda M, Moreno, Amabelle A, Nacion, Aeris Jane D, Roxas, Alberto B, Turingan, Hazel Z, Lapitan, Marie Carmela M, Lukban, Claudine Rosario B, Sacdalan, Marie Dione P, Salud, Jose Antonio M, Reyes, Jeryl Anne S R, Castro, Marinelle M, Rivera, Ron Daniel, Choudry, Maymona J, Salvador, Noruel Gerard A, Szyluk, Karol, Bobiński, Marcin, Rasoul-Pelińska, Karolina, Major, Piotr, Rymarowicz, Justyna, Miotla, Pawel, Futyma, Konrad, Walędziak, Maciej, Reis, Sofia G, Oliveira, João T, Santos, Marisa D, Rocha-Neves, João, Pereira-Neves, António, Gomes, Fabio, Nogueiro, Jorge P M, Rodrigues, Sara Castanheira, Santos, Pedro C, de Araújo Pereira, André, Barbosa-Breda, Joao, Monteiro, Diogo D, Duarte-Gamas, Luís, Nóbrega, Leandro, Dias, Lara R, Ramos, Carlota, Branquinho, Rita G, Cunha, Miguel F, Silva, Nelson J, Deus, Ana Claudia M, Serralheiro, Pedro Azevedo, Soares, Ana P, Henriques, Susana A, Botelho, Pedro, Cismasiu, Brigitta, Barreira, Ana L, Romero, Miguel Ángel Fernández, Santos-Costa, Paulo, Costeira, Cristina, Carvas, João M, Omran, Fayez Mohamed Bin, Latif, Ejaz A, Toffaha, Ali T, Sameer, Mohammad, Qabbani, Amjad S, Elmelliti, Hussam E, El Baba, Hamzah, Khalifa, Mohamed T, Badran, Saif, Ghali, Mohamed Said, Konjanoska, Maja, Kavain, Snezhana B, Kuzmanovska, Biljana, Lleshi, Albert, Kokareva, Anita, Kiprijanovska, Biljana T, Trajkovska, Vanja, Nicevska, Marta T, Gavrilovska-Brzanov, Aleksandra, Burmuzoska, Marjana, Davitkovska, Tatjana, Jakimovski, Aleksandra, Kostovski, Filip, Eftimova, Biljana, Trpeski, Simon, Korunoska-Merdjanoski, Biljana R, Shuntov, Blagoj T, Filipce, Venko, Rendevski, Vladimir, Fileva, Anita, Risteski, Toni, Pejkova, Sofija, Georgieva, Gordana, Srbov, Blagoja, Nikolovska, Bisera, Sotir, Stavridis A, Kasapinova, Katerina, Florian, Ioan Alexandru, Drasovean, Radu, Muresan, Mihai-Stefan MA, Grama, Florin, Chitul, Andrei, Bezede, Cosmin, Ciofic, Emilica, Cristian, Daniel, Toma, Elena Adelina, Calu, Valentin, Miron, Adrian, Enciu, Octavian, Negoi, Ionut, Diaconescu, Ionut Bogdan, Stoica, Bogdan, Stefan, Mihai G, Valeanu, Liana, Radulescu, Raluca Bievel, Bacalbasa, Nicolae Gh, Motas, Natalia, Iliescu, Madalina C, Manolache, Veronica, Davidescu, Mihnea, Serban, Andreea-Madalina, Ionescu, Sebastian N, Bonci, Eduard-Alexandru, Pasca, Andrei, Coman, Roxana A, Vlad, Ioan-Catalin, Lunca, Sorinel, Musina, Ana-Maria, Velenciuc, Natalia, Dimofte, Gabriel, Ginghina, Octav, Mirica, Radu, Iosifescu, Razvan, Vacarasu, Andrei B, Mardare, Mara, Spanu, Andrada, Makkai-Popa, Silviu-Tiberiu, Porumb, Vlad V, Mogoanta, Stelian S, Zarnescu, Narcis O, Costea, Radu V, Zarnescu, Eugenia C, Kaldarov, Ayrat, Kaleda, Vasily I, Kremenchugskaya, Tatiana A, Efetov, Sergey K, Balaban, Vladimir V, Litvin, Andrey, Burlov, Nikita N, Khrykov, Gleb, Butyrskii, Aleksandr G, Dzhumabaev, Khasan E, Pravosudov, Igor V, Ermolaev, Pavel A, Bedzhanyan, Arkady L, Frolova, Yulia V, Kudryavcev, Yurii, Kim, Konstantin, Mikhaylova, Tatyana, Ten, Vyacheslav, Yanishev, Alexey, Novikova, Anastasia, Pavlov, Rostislav, Kim, Gleb, Shmatov, Dmitry, Stolyarov, Maxim, Drozdov, Evgeniy S, Chavkin, Petr Mikhailovich, Gachabayov, Mahir, Niyongombwa, Irénée, Bennett, Stephen P, Mpirimbanyi, Christophe, Katabogama, Jean Bosco, Dieudonne, Hirwa Aime, Costas-Chavarri, Ainhoa, Byiringiro, Fidele, Muneza, Eugene, Liliane, Nzabamwita, Olivier, Kubwimana, Muneza, Severien, Lai, Lee-Min, Ali, Alshahrani Mushabab, Baradwan, Saeed, Alam, Mohammad K, Alzerwi, Nasser A N, Hussain, Arif, Bakhsh, Umar Rahim, Alkhayal, Abdullah, Alnasser, Mohammed H, Rajendram, Rajkumar, Syed, Yadullah, Dagestani, Hattan F, Eissa, Abdullah T, Al Suwailem, Munira A, Farsi, Ali H, Farsi, Deema, Malibary, Nadim, Altaf, Abdulmalik, Basendowah, Mohammed, Baeesa, Saleh S, Akeel, Nouf Y, Trabulsi, Nora Hatem, Bahakim, Abdullah M, Bajunaid, Khalid, Bangash, Mohammed H, Alharthi, Mohammed, Aljiffry, Murad, Sabbagh, Abdulrahman J, Bustangi, Nasir M, Altuwayjiri, Basmah S, Alhaddad, Amani m, Ghunaim, Mohammed A, Samkari, Ali A, Elzain, Mohammed A, AlAmeer, Ahmed Y, Bawa, Dauda, Ghunaim, Hadeel A, Ghunaim, Abdulrhman A, Mousa, Hind Waleen M, Almulhim, Abdulrhman Saleh, Alshammari, Abdulaziz M, Abuzaid, Mohammed, Al Absi, Emad J, Al Duhileb, Mohammed Abdulrazzaq, Duhileb, Al, Almana, Nora E, Alzahir, Ali A, Aldulaijan, Fozan Abdulqader, Madkhali, Tariq, Alshammari, Turki F, Almatar, Bikheet Moh, Ghazwani, Salman Mufareh, Hamid, Amal A, Ghedan, Soliman F, Alhefdhi, Amal, Alomar, Osama, Al-Badawi, Ismail, Salem, Hani, Abu-Zaid, Ahmed, Nazer, Ahmed, Alnemare, Ahmad K, Rayzah, Musaed F, Alzahrani, Ahmed M, Alqahtani, Saad M, Hasson Alnajjar, Anas A, Alyami, Mohammad, Elawad, Amar Faisal, Alqannas, Mashhour H, Cortes-Guiral, Delia, Alalawi, Yousef S, Alayed, Ahmad S, Alishi, Youssef A, Chowdhury, Sharfuddin, Almannie, Raed, Nouh, Thamer, AlAli, Mohammed N, Almalki, Ahmad M, Ahmed, Kaleem, Kattan, Abdullah E, Ayoub, Abdu Hasan, Al-Kharashi, Eyad I, Aljaber, Fahad Khalid, Alghamdi, Abdullah H, Al Hasan, Ibrahim, Badahdah, Fatima Ahmed, Al Faifi, Jubran J, Albarrak, Abdullah A, Niasse, Abdou, Ndong, Abdourahmane, Slijepcevic, Nikola, Paunovic, Ivan, Zivaljevic, Vladan, Kmezic, Stefan, Sekulic, Aleksandar M, Jelenkovic, Jelenko R, Dimitrijevic, Ivan B, Barisic, Goran I, Miladinov, Marko M, Grubac, Zeljko Z, Tadic, Boris S, Grubor, Nikola, Pavlovic, Ivana, Reljic, Milorad, Mitrovic, Milica D, Micic, Dusan, Loncar, Zlatibor, Gregoric, Pavle, Karanikolic, Aleksandar, Perovic, Milan D, Jelovac, Drago, Ilic, Rosanda V, Miljković, Aleksandar D, Bogdanovic, Ivan, Jotic, Ana D, Davidovic, Lazar, Bumbasirevic, Uros, Prijović, Nebojša J, Santric, Veljko, Stankovic, Branko M, Stevanovic, Dejan D, Lazic, Aleksandar V, Mitrovic, Nebojsa D, Zivkovic, Dragana D, Markovic, Ivan Z, Buta, Marko N, Goran, Merima R, Radovanovic, Dragana R, Radovanovic, Zoran, Zahorjanski, Sanja, Protic, Aleksandar Djermanovic Mladjan, Kresoja-Ignjatović, Milana, Djurić, Mladen, Lazovic, Mikan R, Ducic, Sinisa V, Kovacevic, Bojan M, Bojicic, Jovana M, Juloski, Jovan T, Krdzic, Igor, Milutinovic, Vladan Z, Mok, Chi Wei, Dimatatac, Doris Mae, Tan, Ker-Kan, Lieske, Bettina, Lin, Shuxun, Oh, Han Boon, Ngaserin, Sabrina, Koh, Frederick H, Leong, Faith Qi Hui, Kabir, Tousif, Leow, Jeffrey J, Tan, Ming Ngan Aloysius, Ang, Wei-Wen, Shelat, Vishal G, MorochoviÄ, Radoslav, šimko, Kristián, Czako, Ladislav, Gális, Branislav, Vavro, Michal, Dvoranová, Bronislava, Soviš, Marek, Vidová, Ivana, Rems, Miran, Kosir, Jurij A, Tomazic, Ales, Grosek, Jan, Bozic, Tajda Kosir, Hersi, Ismail M, Ali, Abdifatah D, Aidid, Abdisamad A, Farah, Abas A, sh Ahmed, Asma M, Lack, Vered, Fourtounas, Maria, Kloppers, Christo, Almgla, Naser, Panieri, Eugenio, Malherbe, Francois, Hardcastle, Timothy C, Swart, Reinier, Noel, Colin B, Malan, Asha Franciska, Nel, Corné PG, Lugo, Carolina, Lagares, Alfonso, Ojeda-Thies, Cristina, García-Señoráns, Marta Paniagua, Vigorita, Vincenzo, Fernández, Laura Rodríguez, Cano-Valderrama, Oscar, Salido, Andrea Jiménez, Gonzalez, Luis Angel Suarez, Suarez, Sara Busto, Hevia, Mateo, de Arriba Alonso, Mario, Villar, Teresa Renedo, González, Isabel Valentín-Gamazo, Trebol, Jacobo, Mayo-Yáñez, Miguel, López, Cristina Barrena, Mozo, Ana Sánchez, Arencibia, Octavio, Garcia-Cano, Daniel Gonzalez, Viana, Leticia Gómez, Paniagua, Ladislao Cayetano, Martinez-Perez, Carolina, Abellán, Antonio Melero, Romero, Carolina S, Catalá, Juan C, Núñez-García, Bernardo, Gaibar, Antonio Gimenez, García, Natalia Álvarez, Muñoz Vives, Josep M, Calero-Lillo, Aránzazu, Villacampa, José M, Domínguez-Prieto, Víctor, Carneros, Virginia Jiménez, Alonso-Lamberti, Laura, Manuel-Vazquez, Alba, Rubio, Ainhoa Valle, Domenech, Julio, Miranda, Ignacio, Chrzanowska, Hanna Perez, Marquez, Lucila, Baduell, Albert, Balaguer-Castro, Mariano, Carrasco, Pilar Camacho, Vallejo, Marina Cámara, Bitterling, Borja Campuzano, Carreras-Castañer, Anna, Claret, Guillem, Cuesta-González, Francisco J, Di Somma, Alberto, Nora, Joaquim Enseñat, Fabregas, Neus, Fuertes, Ada Ferrer, Ferrés, Abel, Ginesta, Cesar, Gonzalez Sanchez, Jose J, Gracia, Isabel, Hoyos Castro, Jhon A, Jornet-Gibert, Montsant, Morales, Xavier, Mosteiro-Cadaval, Alejandra, Pedrosa, Leire, Carrizo, José Poblete, Renau-Cerrillo, Marina, Reyes Figueroa, Luis A, Ramos, Pedro Roldan, Arboix, Jordi Rumià, Sabater-Martos, Marta, Sieira-Gil, Ramon, Topczewski, Thomaz E, Torales, Jorge, Torné, Ramon, Torner, Pere, Turrado-Rodriguez, Victor, Valero, Ricard, Vives-Barquiel, Marian, Campanales, Marta Suñer, Aguilar, Raúl Jiménez, Bravo, Adriana, Giles, Sergio, Barreda, Daniel Martín, Ferrer, Marc, López, Lorena Gómez, Peraza Godoy, Maria F, Muncunill, Roger Pujol, Medina, David Gutierrez, Postnikov, Yury, Petralanda, Alfonso Alías, Monfort-Mira, Montserrat, Carreras-Castañer, Xavier, Ramirez, Luis J, Torroella-Vallejo, Alba, de Lacy, Borja, Pigrau, Clara Chimeno, Diez, Eloy García, Pagès, Carles Martí, Sobrino, Rocío Gallego, Vargas, Caribay, Segura Nebot, Érica A, Narvaez, Jesús D, Ares, Oscar, Zumbado, Alonso, Madariaga, Salvador E, Llompart Coll, Maria M, Iñiguez, Leticia Torres, González, Carolina, Gómez, Justo, Dominguez, Paula, Montoya, Carolina, Balart, Mariona, Pino, Miguel del, Lillo, Oscar García, Ostilla, Ricardo, Palomino-Chulla, Saúl, López-Baamonde, Manuel, Burgos-Blasco, Barbara, Dziakova, Jana, de Alarcon, Jaime Rodriguez, Vidal-Villegas, Beatriz, Cristóbal, Ignacio, Martinez-de-la-Casa, Jose M, Badenes, Rafael, Moro-Valdezate, David, Andrés-Asenjo, Beatriz De, Bustamante-Munguira, Juan, Aguado, Héctor J, Ruiz-Lopez, Nuria, Pereda-Manso, Adela, Carrascal, Yolanda, González, María Bragado, Álvarez, Elvira Mateos, Cuadrado, Juan Berrocal, Valladares, Sergio Chávez, Méndez, Bárbara Segura, Simon-Perez, Clarisa, Garcia-Virto, Virginia, Alvarez-Ramos, Begoña A, Cervera, M Carmen, Plata, María, Zabalza, Ana, Labrador Hernández, Gregorio de J, Trujillo-Díaz, Jeancarlos, Arribas, Dolores, Vitiello, Giulia, Sánchez-Cabús, Santiago, Llaquet-Bayo, Heura, Martin-Villares, Cristina, Minaya-Bravo, Ana, Medina, Manuel, Gonzalez, Enrique, Sánchez-Gollarte, Ana, Perez, Armando Galvan, Marín, Miguel Ruiz, Bobadilla Romero, Emny R, Prats, Milagros Carrasco, Giménez-Francés, Clara, Gonzalez, Rebeca, Arroyo-Domingo, Marta M, Marínez-Alonso, Jesús A, Maquilón, Alejandra Jara, Guillamon-Vivancos, Laura, Camarena, Ana Isabel Avellaneda, Capitan, Alfonso, Rodriguez, Enrique Viviente, Marco-Garrido, Alfonso, Golet, Marta Roldón, Estaire-Gómez, Mercedes, Calvo, Francisco Javier Redondo, Sánchez-Guillén, Luis, Soler-Silva, Álvaro, Mateo-Sierra, Olga, Quintana-Villamandos, Begoña, Tousidonis, Manuel, Marin, Florencio M, Garcia, Pablo Rodriguez, Freiria Eiras, Miguel A, Vallve-Bernal, Marc, Bleda, Silvia, De Haro, Joaquin, Troncoso, Paula, Martín del Olmo, Juan C, Gómez-López, Juan R, Domínguez, Melody García, Morales-Puebla, Jose M, López-García, Isabel, Escartin, Jorge, El-Abur, Issa Talal, Aguilera, David García, Martin-Sole, Oriol, Pérez-Bertólez, Sonia, de Haro Jorge, Irene, Corres, Oscar Izquierdo, Mora-Guzmán, Ismael, Oliver Guillen, Jose R, de-Fernandez, Alina Lopez, San-Jose, Beatriz Fernandez-Velilla, Bergkvist, David Julià, Ruiz-Villa, Laura, Marín, Eduardo González, Melero, Alba Vázquez, Varela, Lorena, Calvo, Mikel Prieto, Ateca, Ibabe Villalabeitia, Perfecto, Arkaitz, Carnicero, Patricia Alonso, Aranda, Elena, Martin-Playa, Patricia, Elizalde, Leire Aparicio, Galvañ, Yaiza, Plata-Bello, Julio, Fernández-Fernández, June, Rahy-Martín, Aida C, Rosas-Bermúdez, Clara, Pelloni, Maria, Di Martino, Marcello, Pendolero, Jorge Prada, Pérez, David Díaz, Losada, Manuel, García-Conde, María, Diéguez, Beatriz, Hernandez-Garcia, Miguel, Vidal, Francisco Ripoll, Zabaleta, Jon, Barrueco, Alvaro Sánchez, Beltran-Miranda, Pablo, Morales-Puebla, Jose M, Guevara-Martínez, Jenny, Arteaga Asensio, Pablo C, Saudí, Sef, Jariod-Ferrer, Ursula M, Duque-Mallén, Maria V, Dobon, Miguel A, Gracia-Roche, Carlos, Mendoza-Moreno, Fernando, Palacios, Nelson Morales, Diez-Alonso, Manuel, Matías-García, Belen, Diego, Lucía, Blázquez-Martin, Alma, Burgos-Blasco, Patricia, Ramos, Diego, Berna-Rico, Emilio, Ley, Luis, Sánchez-Fernández, Fátima, Río-Arroyo, Laura Del, Barberá, Rafael, Sánchez, Alberto Cabañero, Barranquero, Alberto G, Montes-Jovellar, Lourdes, Tejero-Pintor, Francisco J, Estévez, Javier Mata, Colás-Ruiz, Enrique, Gomez-Perez, Beatriz, Moya-Angeler, Joaquin, Delegido, Ana, Vázquez, Pedro José Gil, Alconchel, Felipe, León-Muñoz, Vicente J, López, Tatiana Nicolás, Pintor-Tortolero, Jose, Tallon-Aguilar, Luis, Dios-Barbeito, Sandra, Capitán, Luis C, Gomez-Rosado, Juan-Carlos, Capitán-Morales, Luis C, Landaluce-Olavarria, Aitor, Ripollés-Melchor, Javier, Abad-Motos, Ane, Sáez-Ruiz, Elena, Ruiz-de-la-Hermosa, Alicia, Perez-Ferrer, Antonio, Moriche-Carretero, Manuel, Revilla-Amores, Remedios, de Colsa, Daniel Serralta, Alcaide, Benito, Martín-Láez, Rubén, Cano-Trigueros, Emiliano, Soria-Aledo, Víctor, Aguado, Nuria, Segura-Sampedro, Juan J, González-Suárez, Susana, Espinosa-Bravo, Martin, Nuñez, Jorge H, Vilallonga, Ramon, Gil-Moreno, Antonio, Gil-Sala, Daniel, Espin-Basany, Eloy, Blanco-Colino, Ruth, Lopez, Manuel, Micó, Jacob Motos, Basnayake, Oshan, Jayarajah, Umesh, Wijekoon, Naveen S, Jayawardane, Indu A, Subasinghe, Duminda, Seneviratne, Sanjeewa A, Wickramasinghe, Dakshitha P, Chandrasinghe, Pramodh, PBThalgaspitiya, Sujeewa, Jayathilake, Anuradha B, Wijenayake, Wasantha, Omer, Israa A, Mustafa, Eman Elsadig, Abdallah, AlQasim Mohammed Ahmed, Ali, Ali A, El Hunjul, Ghalib N, Mukhtar, Deema Mohamedfagir Osman, Hussein, Mustafa Mohamed Ali, Shogar, Abdoalsalam, Abdallah, Muneeb E, Shaar, Abdalkader, shaar, Mohamed Nafea, kora, Mohamad khaled, Muhmmed, Khadija Ala, Sarih, Monira Mohammed, Omer, Mohammed E A, Idris, Moyasar A, Osman, Osama S, Alawad, Elharith MA, Ebad, Mustafa Abdalla Bakhit, Ibrahim, Ahmed M, Abass, Khider Altayeb Bakheet, Nour, Alshareef Bakri Yousif Mohamed, Hamid, Hytham K S, Ahmed, Khabab Abbasher Hussien Mohamed, Ibrahim, Mohja Elsheikh Obeid, Yassin, Abubaker M, Abdelrahman, Salma Esam Mohamed Elhassan, Alnaser, Adnan Ayman, Taha, Tarig M, Adam, Mohammed E A E, AAhmed, Abdelkareem, Ebad, Mustafa Abdalla bakhit, Saadelnour, Mohammed Ahmed Idrees, Adlan, Ali Mohamed Ahmed, Ismail, Azzain, Alkhalifa, Elmustafa, Abdalaal, Ibrahim Ali Mohamed, Fadalla, Tarig, Ibrahim, Mohamed Yahia, Hamdoun Aziz, Elaf A, Mohammed, Muhsin Mohammed E A, Mohamed, Tasneem A, Alhag, Ali Alsaeed Ali, Mohamed, Rayan Ibrahim Hamid, Hamza, Salih Boushra, Ali, Mohamed Abdelazim Mohamed, Ahmed, Nidal Youseef A A, Alhag, Albrra Alhag Mohamed, Saleh, Mahmoud, Alkhalifa, Elmustafa, Jawad, Monir, Thorell, Anders, Segelman, Josefin, Hultgren, Rebecka, Elbe, Peter, Chew, Michelle S, Mohseni, Shahin, Buchwald, Pamela, Älgå, Andreas, Sandblom, Gabriel, Nordberg, Martin, Sund, Malin, Rutegård, Martin, Nikberg, Maziar, Mongelli, Francesco, Di Giuseppe, Matteo, Papadia, Andrea, Gasparri, Maria Luisa, Antonilli, Morena, Popeskou, Sotirios-Georgios, Colucci, Nicola, Gialamas, Eleftherios, Dwidar, Oliver, Sauvain, Marc-Olivier, Maurus, Christine F, Kocher, Gregor J, Widmer, Lukas W, Mueller, Simon A, Giger, Roland, Hool, Sara-Lynn, Adamina, Michel, Peros, Georgios, Misirlic, Merima, Bächler, T, Schöni, Daniel, Taha, Anas, Gass, Jörn-Markus, Giesen, Thomas, Gero, Daniel, Däster, Silvio, Soysal, Savas D, Taha-Mehlitz, Stephanie, Tampakis, Athanasios, Hess, Gabriel F, Nocera, Fabio, Kollmar, Otto, Bolli, Martin, Mohammad, Mazen A, Bakdash, Anas M, Aljasem, Ramez KH, Rahhal, Amer A, Shareeda, Mohamad A, Nyno, Anas O, kahawati, Mahran Adnan, Yassien, Bassiel Alchiekh, Alsaid, Bayan, Bnayan, Reham M, Kouz, Basel S, Takahji, Mohammad Eyad, Hasan, Zein Fouad, Abduljalil, Aalaa, MAlhalabi, Nawras, Al Jammal, Mohamad Basher A, Alia, Diana N, Homsi, Muhannad, Masri, Joseph, Masri, Ruqaya J, Toutounji, Tayf, Al Aliwy, Marwan, Kabbani, Nasrullah, Kadoura, Lama, Sultan, Dana, Kassem, Luma Haj, Al-Naeb, Houmam Mohamad, Al-Hajjaj, Maher M, Alkhaleel, Wael, Swed, Sarya, Naal, Mohammad Yusuf, Tfankji, Salim, Almohammed, Mohammad Husein Rajab, Nabhan, Mohammad Hassan, Al-Mouakeh, Ahmad, Najjar, Mahfoud M, Alhashash, Ahmad, Ghazal, Ahmad, Alchallah, Mhd Obai, Alolabi, Homam, ElHomsi, Muhammad Omar, Rayes, Omar, Ezzdean, Weaam K, Naem, Antoine, Al-Houssami, Salma MHD Mazen, Gawrieh, Bardisan S, Hamdan, Alaa, Hassan, Naya Talal, Hammed, Ali M, Elias, Elias George, Ahmad, Aline Ali, Knifaty, Mohammed Amr, Moussa, Ahmed M, Yabasin, Iddrisu Baba, Roan, Jun-Neng, Shih, Chao-Jung, Chen, Po Chuan, Lohsiriwat, Varut, Phupong, Vorapong, Techapongsatorn, Suphakarn, Lalchan, Avery M, Charles, Shane, Rim, Bouchahda, Bouhani, Malek, Ghalleb, Montassar, Chamakhi, Amine, Sebai, Amine, dahman, Nesrine Ben hadj, Ammar, Houssem, Said, Mohamed Amine, Kechiche, Nahla, Aghayeva, Afag, Dülgeroğlu, Onur, Ozben, Volkan, Aytac, Erman, Atasoy, Deniz, Arikan, Akif Enes, Kara, Halil, Dogan, Nasuh U, Bostanci, Asli, Turhan, Murat, Ozkan, Ozlenen, Dumlu, Ersin G, Menekşe, Ebru, Oter, Volkan, Piskin, Erol, Hasirci, Ismail, Colakoglu, Muhammet Kadri, Bostanci, Erdal Birol, Ozgun, Yigit Mehmet, Girgin, Behic, Erel, Serap, Demirel, Sibel, Yanik, Özge, Gecim, Ibrahim Ethem, Koc, Mehmet Ali, Akyol, Cihangir, Güner, Volkan, Konca, Can, Batioğlu, Figen, Hakseven, Musluh, Toptas, Tayfun, Aydin, Yener, Ulas, Ali B, Ince, Ilker, Altinel, Yuksel, Demirgan, Serdar, Meric, Serhat, Sevdi, Mehmet Salih, Ercetin, Candas, Ferahman, Sina, Aydin, Husnu, Dural, Ahmet Cem, Sahbaz, Nuri A, Yalkin, Omer, Sen, Murat, Isik, Ozgen, Yilmazlar, Ahmet Tuncay, Bisgin, Tayfun, Yigit, Banu, Isik, Arda, Leventoglu, Sezai, bayhan, Hüseyin, Buldanli, Mehmet Z, Gultekin, Murat, Cennet, Omer, Unal, Ertekin U, Çakici, Mehmet Çağlar, Iplikci, Ayberk, Yildirim, Asif, Ozgur, Ilker, Sen, Comert, Dincer, Muserref B, Erginöz, Ergin, Sanli, Ahmet Necati, Turna, Akif, Askar, Ahmet, Uludağ, Server Sezgin, Guldogan, Cem E, Ozmen, Mehmet M, Bozkurt, Mehmet A, özcan, Adem, Kara, Yasin, Kocataş, Ali, Guner, Ali, Sari, Ramazan, Memisoglu, Ecem, Saracoglu, Kemal T, Tosun, Yasin, Çetin, Kenan, Kalafat, Erkan, Taskiran, Cagatay, Vatansever, Dogan, Giray, Burak, Tatar, Ozan C, Köksal, Hande, Özkent, Mehmet Serkan, Ulutaş, Mehmet E, Hamarat, Mustafa B, Coskun, Bora, Abbasov, Aykhan, Altinsoy, Ezgi, Uprak, Tevfik Kivilcim, Saracoglu, Ayten, Ugurlu, M Umit, Kose, Emin, Ozgen, Utku, Sungurtekin, Ugur, Gonullu, Emre, Bayhan, Zulfu, Akin, Emrah, Mantoglu, Baris, Colak, Elif, Kucuk, Gultekin Ozan, Yuksel, Cemil, Aydin, Ferit, Dogan, Lutfi, Culcu, Serdar, Tufan, Aydin Eray, Citgez, Bulent, Akpinar, Göksever, Köksoy, Ülkü C, Ulgur, Hanife Seyda, Kalin, Murat, Ozkan, Omer Faruk, Yildirak, Muhammed Kadir, Atici, Semra Demirli, Salimoğlu, Semra, Abud, Burcin, Calik, Bulent, Kamer, Erdinc, Kebabci, Eyup, Uylas, Ufuk, Teker, Kenan, Cakmak, Guldeniz Karadeniz, Gultekin, Fatma Ayca, Xaviour, Okedi Francis, Isaac, Otolia, Gaston, Turinawe, Asiimwe, Daniel, Vahwere, Bienfait Mumbere, Sikakulya, Franck Katembo, Lule, Herman, Lugobe, Henry Mark, Lekuya, Hervé Monka, Namugenyi, Christine, Kiweewa, Ronald, Bosco, Muhangi, Yovenko, Ihor, Kopetskyi, Viacheslav, Maksymenko, Bogdan, Alshryda, Sattar, Khan, Sabina A, Padvi, Amit Vasantrao, Serour, Mohamed A, Beigh, Shamim Ahmad, Elsayed, Hisham M, Mohamed, Awadelkarim O, Basappanavar, Vikram Somashekhar, Al-Wandi, Amna S, Khalil, Kareem S, Younis, Muhammad Umar, Al Saadi, Hayder S Abdulhadi, Heidan, Ginan K, Trehan, Ravi K, Davies, Justin, Ashcroft, James, Stewart, Grant D, Georgiades, Fanourios, Durrani, Amer J, Price, Stephen J, Wong, Kai Yuen, Agrawal, Amit, Seah, Matthew KT, Saad, Marwa M E, Segaren, Nicholas, Ghobrial, Marios, Balakrishnan, Anita, Forouhi, Parto, Khan, Wasim S, Wheeler, James, Schache, Andrew G, Katsikostas, Dimitrios P, Angelou, Dimitrios, Fell, Adam J, Madani, Rana, Dindyal, Shiva, Seraj, Shaikh S, Sharavanan, Premalatha, Iqbal, Muhammad R, Wong, Nicholas J, Lo, William B, Soon, Wai C, Hammouche, Dalia, Lee, Jonathan DE, Pachl, Max J, Alexander, Dinesh, Ahmad, Shoaib, Morley, Hannah L, Selwyn, David, Wareing, Jonathan, Oktseloglou, Vlasios, Bobak, Peter, Rampersad, Lisa S, Mohamed, Mazin, Kaur, Mandeep, Athanasiou, Antonios, Martin, Benjamin P, Jichi, Tarik S, Batchelor, Tim JP, Rozwadowski, Sophie, Maniarasu, Sarveen, Seyed-Safi, Parisah K, Kutuzov, Vladislav, Shah, Hemina B, Noton, Toby M, Dela Cruz, Nina Jyne Minette, Trehan, Neev, Tokidis, Evripidis, Byrne, Matthew H V, Winter, Stuart C, Pinto-Lopes, Rui, Pavithran, Aswathy, Khalifa, Ahmad O, Eardley, Nicola J, Ashour, Rami, Steinke, Jacqueline D, Esmail, Husayn D, Bence, Matthew N, Walters, Samuel T, Akinyemi, Tosin O, Lakpriya, Sathya, Moawad, Nader N, Panahi, Pedram, Lau, Joshua, McAleer, Stephen, Laoye, Adeyinka, Hussain, Abdulzahra Abdulsamad, Zafar, Muneeb, Elsheikh, Mohammed H, Shaerf, Daniel A, Soggiu, Fiammetta, Massoumi, Abaris, Sheth, Hemant D, Gareb, Fahed, Yao, Mark W, Qamar, Mubasher A, Fang, Clarissa E H, Greenhalgh, Michael S, Hunt, Alexander, Oladeji, Emmanuel O, Benjamin, Miles W, Beak, Philip, Rae, Fraser J, Aithie, Joanna M S, Clarke, Gareth W J, Veeramootoo, Darmarajah, Ashman, Alex J, Kahka, Ehab E, Rafe, Tanvir, PATEL, PANNA K, Albirnawi, Hatim, Katory, Mark, Fisher, Ann, Amonkar, Sunil J, Rao, Pawan Kumar Dhruva, Holroyd, David J, Caruana, Edward J, Gkikas, Andreas, Newton, Lydia S, Kirk, Alan J B, Khalid, Ayesha, Ferguson, David, Stanier, Paul B, Shah, Vinay, El-Boghdadly, Kariem, Schizas, Alexis M P, ilyas, Minahi, George, Mark L, Gawad, Mothana, Groom, William D, Al-Azzawi, Mohammed, Ahluwalia, Julian CJ, Punjabi, Prakash P, Cheung, Fang Yi, Wilson, Michael D, Mitrofan, Claudia Gabriela, Malam, Yogeshkumar, Townson, Adam, Loubani, Mahmoud, Yau, Jih Dar, Seebah, Kevin, Akowuah, Enoch F, Pushpoth, Sreekumari R, Viswanath, Yirupaiahgari KS, ElSanhoury, Kareem, Chew, Misha, Walker, Thomas E, Elhassan, Almutasim Billah Elbagir, Belcher, Elizabeth, Goricar, Matej, majd, Hooman Soleymani, Knight, Dominic, Ismail, Lamiese, McKinnon, Chris, Ganau, Mario, Prokopenko, Max, Doshi, Neel S, Gkorila, Aikaterina, Sheikh, Nomaan A, Helm, Jessica R, Low, Mei Ken, Ogunfusika, Oluseyi Harold, Bisheet, George, Alhammali, Tariq, Arnob, Ahmed Showki, Singh, Jatinder, Allde, Emma L, Sambhwani, Sharan H, Dube, Manas, Gemmill, Elizabeth H, John, Joby, Gerogiannis, Ioannis N, Abuelgasim, Mona A A, Crate, Georgina, Holme, Thomas J, Nguyen, Anh T V, Ho, Michael W, Wade, Ryckie G, Hussain, Azar, Andrzejowski, Paul, Omakobia, Eugene, Eltayeb, Momin, Galabov, Tsanko P, Lee, Chung Yan Vernon, Nazir, Anum, Siaw, Oliver L, Ashford, Robert U, Boddy, Alex P, Ashmore, Christopher D, Shah, Snehadhar M, Gowers, Benjamin T V, Thekkinkattil, Dinesh K, Worku, Dawit, Sambhwani, Sharan H, Harky, Amer, Talwar, Rishi, Sagoo, Harkiran K, Jambulingam, Periyathambi S, Smart, Christopher J, Doherty, Daniel T, Mastoridis, Sotiris, Kumar, Sidharth, Mahmoud, Rana, Solari, Francesca, Egan, Richard J, Barry, Jonathan D, Morrison, Jo, Davoudi, Kaveh, Hollyman, Marianne, Kelly, Andrew, Badenoch, Thomas F, pandanaboyana, sanjay, Critchley, Rebecca J, Sarodaya, Varun R, Sinnerton, Robert J H, Manickavasagam, Jaiganesh, Lindsay, Elizabeth F, Arora, Ankita, Hasan, Raashad, Liew, Ignatius, Ozua, Joshua, Kouritas, Vasileios, Collins, Rachael V, Lafford, George H, Moret, Charlie, Chean, Chung Shen, Horgan, Liam F, Aujayeb, Avinash, Siddique, Muhammad Harris, Navaratne, Lalin, Kotecha, Sanjeev, Bellato, Vittoria, Lewis, Sophia E, Ali, Muhammad Usman, Marson, Ben A, Craxford, Simon, Gajjar, Ketankumar, Theophilidou, Elena, Aboelmagd, Tariq, Khatkar, Harman, Ganau, Mario, Awadallah, Mahmoud A, Blanco, Jose A, Chituku, Tsitsi G, Dixon, Oliver GB, sarveswaran, Janahan, Jones, Imogen S, Hammouche, Salah, Vijay, Vardhini, Ooi, Rucira, Karmarkar, Rahi, Khaleeq, Tahir, Bhatia, Mohit, Al-Khazaali, Badr L, Daadipour, Audrina, Mattar, Ahmed, Singhal, Tarun, Mahmoud, Moustafa Ibrahim, Glasbey, James, Nankivell, Paul C, Kalkat, Maninder S, Nour, Shahd, Beggs, Andrew D, Yershov, Danylo Y, Chughtai, Shafiq Ahmad, Youssef, Hesham, Norrish, Alan R, Mohammed, Mohammed M, Gwozdz, Adam M, Charalambous, Michalis P, Knight, Stephen R, McCaul, James A, Bridgman, Elsie A, El Sheikh, Mustafa, Ogunbowale, Akinsola, Wright, Evan O, Ahmed, Usama, Younus, Hafsa, Tincknell, Laura G, Weixing-Ho, Ken, Demetriou, Charis, Hussei, Mohammed, Reilly, John-Joe, Hormis, Anil P, Moug, Susan J, Anazor, Fitzgerald C, Horwell, Edward A, Neal-Smith, Gregory, McNamara, John M, Baryeh, Kwaku W, Bhatti, Khalid M, McKay, Joseph E, Cannoletta, Maria G, Perkins, Clare J, Gopalswamy, Sivakumar, Sheldon, Anna F, John, Joseph B, Mantle, Mark, Toia, Bogdan, Phillips, Andrew J, Al-Khyatt, Waleed, Lund, Jonathan N, Ammar, Ahmed Y, Lederhuber, Hans, Yim, Guang H, Huntley, Daniel A, Daniels, Ian R, Valverde, Joao, Lumley, Edward David John, Walton, Thomas J, Raptis, Dimitri A, Dimitrokallis, Nikolaos, Nathan, Arjun, Motallebzadeh, Reza, Chowdhury, Shihab, Ahmed, Rezwan F A, Mirnezami, Reza, Szakmany, Tamas, Knight, Dominic J, Al-Azzani, Waheeb, Davies, Huw R, Ooi, Setthasorn Zhi Yang, Oo, Khaing K, Cullis, Paul S, Peng, Ed, Demetriades, Andreas K, Tambyraja, Andrew L, Poon, Michael TC, Drake, Thomas M, Brennan, Paul M, Oikonomou, Dimitrios, Newman, Samuel E, Le Blevec, Louise, Otify, Mohamed, Szatmary, Peter, Devkaran, Bhavesh, Sochorova, Dana, Sohrabi, Catrin, Sivaprakasam, Rajesh, Goh, Mingzheng Aaron, Atkinson, Kate V, Soares, Delvene, Prce, Daniela, Cann, Johnathon P, Grobbelaar, Amy C, Bradley, Rebecca, Strauss, Helen J, Taha, Ahmed, Minicozzi, Annamaria, Venn, Mary L, Thakur, Bhaskar, Hanoun, Abdullah, Goru, Poornanand, Baumber, Rachel M, Sobti, Anshul S, Cross, George WV, Havenhand, Tom, Antoniou, George A, Chauhan, Govind Singh, Vokshi, Ismail, Mahmud, Ayesha, Albanese, Erminia, Evans, Daisy, Madhuri, Thumuluru Kavitha, Horsnell, Jonathan D, Zalmay, Pardis, Mohamed, Mazin, Davies, Angharad J, Aljanadi, Firas, Jeganathan, Reubendra, Jones, Mark, Kakos, Christos, vidya, Raghavan, El-Ghobashy, Alaa, Habib, Ahmed M, Reid, Jeremy P, Rajgor, Harshadkumar Dhirajlal, Ahmed, Omar, Branagan, Graham, Mohamedahmed, Ali Yasen Y, Nour, Shahd, Al-Sabbagh, Ali, Chetty, Govind, Kelty, Clive J, EL-Wajeh, Yasin A M, Tomlinson, James E, Edwards, John G, Rominiyi, Ola, Sinha, Saurabh, Saad, Sanad, Sahu, Banchhita, Charalampakis, Vasileios, Enemosah, Ibrahim, Williams, Simon J, Yaqoob, Hassan N, Laurent, Edward P, Moreau, Joshua L, Frostick, Rhiannon, Parwaiz, Hammad, Aboelmagd, Karim, Pournaras, Dimitri J, Hristova, Kalina H, Iyengar, Karthikeyan P, Mohamed, Muyed, Artioukh, Dmitri Y, Anwar, Sibtain, Hussein, Mostafa K A, Omogbehin, Tomisin S, Herron, Jonathan B T, Labib, Amir, Patel, Preemal, Marsden, Samuel C, Mehdian, Roshana, Santhirakumaran, Gowthanan, Smelt, Jeremy, Agarwal, Ketan, Athanasiou, Antonios, Lancerotto, Luca, Sahnan, Kapil, Shalhoub, Joseph, Donnelly, Liam J, Erridge, Simon, Chidambaram, Swathikan, Luo, Xun, Bansal, Sujesh, Ryan, Neil AJ, Smith, Alexander C D, Flatman, Michael, Wafaie, Imad, Malik, Muhammad Isfandyar Khan, Thumbadoo, Ruben P, Hussain, Shoaib F, Henein, Christin, Hamad, Yousif T, Belgaumkar, Ajay P, Bosanquet, David C, Kolias, Angelos G, Choi, David, Marcus, Hani J, Horsfall, Hugo RM Layard, Khan, Danyal Z, Sahni, Arun, Millward, Christopher P, Render, Luke, Truss, Adam, Elmoslemany, Tarek, Parmar, Chetan, Hanger, Joseph, Sheen, Jonathon, Rait, Jaideep S, Foreman, Jennifer, Marzouqa, Natalie, Fontalis, Andreas, Voulalas, Grigorios, CHEONG, Ryan Chin Taw, Dindyal, Sanjay, Arumugam, Sathyaseelan, Ward, Thomas R W, Stephens, Alastair S, Douka, Eleftheria, Mahmud, Ayesha, Abou-Foul, Ahmad K, McKay, Siobhan C, Kitchen, Mark O, Rees-Stoner, Oliver DJ, Balasubramanya, Supriya, Akhtar, Muhammad Adeel, Warwick, Andrew J, Pawar, Shweta, Dubey, Vivek, Al-Yaseen, Mustafa W, Williams, Christopher YK, Laird, Alexander, Krishna, Kandaswamy, Anyaugo, Ngozi S, Wuraola, Obafemi K, Odejinmi, Funlayo, Craven, Joanna M, West, Charlotte L, Barter, Reece A, Navaratnam, Devaraj M, Malik, Shahbaz S, Mahendran, Vimaladhithan, Zilvetti, Miguel, Lovegrove, Richard E, Board, Tim N, Zeiton, Moez, Sarwar, Safdar A, Duff, Sarah E, Hsabo, Elmuiz A, Goru, Poornanand, Nugur, Ashwani Kumar, Morris, Richard M, Lala, Anil K, Kwan-Feinberg, Rita O, Ross, Samuel W, Dressler, Jeremy A, McClain, Craig D, Evans, Faye M, Wason, Shaun E L, Vogel, Keianna R, Wang, Joanna C, Sulciner, Megan L, Hirji, Sameer, Raoof, Mustafa, Wolff, Christopher J, kent, Ilan, Turan, Alparslan, Teixeira, Pedro G, Olson, Kristofor A, Patel, Neil D, Krishnamoorthy, Vijay, Moris, Dimitrios, Rice, Henry E, Gabr, Hesham, Satoskar, Savni R, Castater, Christine A, Jmaileh, Manal, Payne, Rachel E, Kwon, David S, Aarabi, Shahram, Escobar, Pedro F, Kronenfeld, Joshua P, Dalton, Michael K, Etchill, Eric W, Haut, Elliott R, Vervoort, Dominique, Dehal, Ahmed, McKenney, Mark, Elkbuli, Adel, Gosain, Ankush, Abdelsattar, Zaid M, Naunheim, Matthew R, Burks, Ciersten A, Zhou, Allen S, Heng, Marilyn, Abohashem, Shady, Lozano-Calderón, Santiago A, Reisenauer, Janani S, Mouawad, Nicolas J, Diehl, Thomas M, Eriksson, Evert A, Marwaha, Jayson S, Schroeppel, Thomas J, LaRocca, Christopher J, Chang, Grace H, Hassan, Romana, Nosanov, Lauren B, Rickard, Jennifer L, Avraham, Jacob B, Petrone, Patrizio, Sferra, Joseph J, Hadaya, Joseph, Mead, Brittany S, Hauptman, Jason S, Ahmad, Maleeha, Meola, Antonio, Chang, Steven D, Ko, Ara, Specht, Katherine E, Choudhry, Asad, Encalada, Ronald Zerna, Poggio, Juan L, Xing, Hang, Glass, Nina E, Hooker, Robert, Martins, Paulo N, Scott, Erin M, Bankhead, Brittany K, Giorgakis, Emmanouil, Nigh, Joe, Osborn, Tamara, Tay Lasso, Erika L, Beswick, Daniel M, Berndtson, Allison E, Kaups, Krista L, Chen, Lee-lynn, Farrell, Michael S, Boeck, Marissa A, Vaysburg, Dennis M, Kassam, Al-Faraaz, Turner, Kevin M, Dyas, Adam R, Coleman, Julia R, Folsom, Megan, Lam, Christopher M, Kumer, Sean C, Larson, Kelsey, Turner, Scott, Guidry, Christopher, Reddy, Madhuri, Berbel, German, Findley, Austin, Beahm, David, Bur, Andres, Marlor, Derek, Houndschell, Corey, Carver, Shea, Ulrich, Alissa, Bhutiani, Neal, DiChiacchio, Laura, Abdou, Hossam, Napolitano, Lena M, Ghebre, Rahel, Bass, Gary Alan, Kaplan, Lewis J, Martin, Niels D, Duffy, Caoimhe C, Abdelhamid, Sultan S, Daley, Brian J, Roland, Christina L, Dumas, Ryan P, Ban, Vin Shen, Rajesh, Aashish, Davies, Mark G, Purudappa, Prabhudev P, Walters, Camila B, Lin, Nicole, Ruzgar, Nensi M, Ullrich, Sarah J, Trostchansky, Ivan, Bonilla-Cal, Fernando, Castedo, Fabiola, Sobrero, Helena, Acuña, Gastón, Álvarez, Sofía M, Tarigo, Josefina, Carbajal, Ana C, Carbajal, Ana, Reyes, Antonio R, Al-Eryani, Fatima A, Alqousi, Nardeen N, Alattas, Zainab, Al-Saban, Rafat A, Al-Shehari, Mohammed M, ALHammadi, Nawal T, Shream, Sarah A, Al-Naggar, Hamza M, Al-Qalisi, Lina M, Nadeesh, Areej E, Al-Samawi, Hytham H, Bajjah, Hadeel M, AL-Ameri, Saba A, Albably, Jamal F, Ghannam, Rana A, Shamsan, Amatallah H, Meead, Abdullah A, Al- Zubaidi, Riham Q, Zulait, Mohammed A, Najeeb, Halah, Alsayadi, Musaed M, Al-Mashreqi, Seham K, Al-Jomai, Najla A, Alsayadi, Ramzi A, Al-Naggar, Moath M, Almarashi, Hassan A, Musaeed, Hasna M, Al-Raimi, Ibrahim M, Ghanem, Hossam N, Al-Zazay, Karim A, AL-Mahdi, Shehab A, Almontaser, Amatalaleem S, Savopoulos, Vanessa A S, Munthali, James, Kabongo, Kizito M C, Mushiwokufa, Willard, Ngulube, Allan, Ntoto, Crispin, Magama, Praise T, Dzinotyiwei, Daniel, Chivanga, Shelton K, Dube, Ngqabutho S, Sanchez, Ernesto C, Moyo, Assel T, Chengahomwe, Antony, Chinyowa, Simbarashe, Siamuchembu, Maphios, Bondera, Tafadzwa, and Mushawarima, Trust
- Abstract
The 2015 LancetCommission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system strengthening and address growing backlogs.
- Published
- 2022
- Full Text
- View/download PDF
20. Are biomarkers expression and clinical-pathological factors predictive markers of the efficacy of neoadjuvant chemotherapy for locally advanced cervical cancer?
- Author
-
Ditto, Antonino, Longo, Mariangela, Chiarello, Giulia, Mariani, Luigi, Paolini, Biagio, Leone Roberti Maggiore, Umberto, Martinelli, Fabio, Bogani, Giorgio, and Raspagliesi, Francesco
- Subjects
NEOADJUVANT chemotherapy ,CERVICAL cancer ,MACHINE learning ,LYMPHADENECTOMY ,BIOMARKERS ,STATISTICAL learning ,CLINICAL prediction rules - Abstract
To predict the overall pathologic response to neoadjuvant chemotherapy (NACT) of patients with locally advanced cervical cancer (LACC) creating a prediction model based on clinical-pathological factors and biomarkers (p53, Bcl1 and Bcl2) and to evaluate the prognostic outcomes of NACT. This is a retrospective study of 88 consecutive patients with LACC who underwent NACT followed by nerve sparing surgery with retroperitoneal lymphadenectomy at National Cancer Institute of Milan, between January 2000 and June 2013. Clinical pathologic data were retrieved from the institutional database. Biomarkers (p53, Bcl1 and Bcl2) were evaluated before and after NACT in the specimen. To investigate their role as predictors of response, we tried several statistical machine learning algorithms. Responders to NACT showed a 5-years survival between 100%(CR) and 85.7%(PR). Clinical factors were the most important predictor of response. Age, BMI and grade represented the most important predictors of response at random forest analysis. Tree-based boosting revealed that after adjusting for other prognostic factors, age, grade, BMI and tumor size were independent predictors of response to NACT, while p53 was moderately related to response to NACT. Area under the curve (crude estimate): 0.871. Whereas Bcl1 and Bcl2, were not predictors for response to NACT. The final logistic regression reported that grade was the only significant predictor of response to NACT. Combined model that included clinical pathologic variables plus p53 cannot predict response to NACT. Despite this, NACT remain a safe treatment in chemosensitive patients avoiding collateral sequelae related to chemo-radiotherapy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
21. Molecular markers and endometrial cancer.
- Author
-
D'Oria, Ottavia, Bogani, Giorgio, Vizza, Enrico, Chiantera, Vito, Muzii, Ludovico, Salerno, Maria Giovanna, Caserta, Donatella, Laganà, Antonio Simone, Tinelli, Andrea, Corrado, Giacomo, and Giannini, Andrea
- Published
- 2022
- Full Text
- View/download PDF
22. Uterine serous carcinoma: role of surgery, risk factors and oncologic outcomes. Experience of a tertiary center.
- Author
-
Ditto, Antonino, Leone Roberti Maggiore, Umberto, Lopez, Salvatore, Martinelli, Fabio, Bogani, Giorgio, Lo Vullo, Salvatore, Brusadelli, Claudia, Paolini, Biagio, Ducceschi, Monika, Mantiero, Mara, Chiappa, Valentina, Signorelli, Mauro, Evangelista, Mariateresa, Mariani, Luigi, and Raspagliesi, Francesco
- Subjects
PROPORTIONAL hazards models ,MINIMALLY invasive procedures ,HYPERTHERMIC intraperitoneal chemotherapy ,SURVIVAL rate - Abstract
To evaluate factors impacting survival outcomes in patients with uterine serous carcinoma (USC). Data of consecutive patients diagnosed with USC undergoing surgery between 2000 and 2020 at Fondazione IRCCS Istituto Nazionale Tumori of Milan (Italy) were reviewed. Progression-free (PFS) and overall survival (OS) outcomes were evaluated using Kaplan-Meier and Cox proportional hazard models. Records of 147 consecutive patients meeting the inclusion criteria were analyzed. Stage distribution was: 67 (45.6%) patients with early-stage with uterine confined disease and 80 (54.4%) with advanced stages disease. Minimally invasive surgery was performed in 43 patients (29.5%). The median follow-up period was 78.6 months (IQ range = 35.7–117.3 months). The overall recurrence rate was 41% (60 patients): 19/67 patients (28.4%) with early-stage disease and 41/80 patients (51.3%) with advanced stage. The 5-year PFS rate was 35.0% (95% confidence interval [CI]: 27.5–44.7%). In multivariate analysis, age, BMI, depth of myometrial invasion, cytology, and optimal cytoreduction with postoperative residual tumor absent significantly impacted on PFS. The 5-year OS rates were 46.5% (95% CI: 38.1–56.8). The result of multivariate analysis showed that there was significant difference in OS based only on optimal cytoreduction and accuracy of retroperitoneal surgery. In apparent early-stage USC, peritoneal and retroperitoneal staging allows to identify patients with disease harboring outside the uterus. Optimal cytoreduction is the most significant prognostic factor. Further collaborative studies are warranted in order to improve outcomes of USC patients. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
23. The Adoption of Radiomics and machine learning improves the diagnostic processes of women with Ovarian MAsses (the AROMA pilot study).
- Author
-
Chiappa, Valentina, Bogani, Giorgio, Interlenghi, Matteo, Salvatore, Christian, Bertolina, Francesca, Sarpietro, Giuseppe, Signorelli, Mauro, Castiglioni, Isabella, and Raspagliesi, Francesco
- Abstract
Purpose: To develop and evaluate the performance of a radiomic and machine learning model applied to ultrasound images in predicting the risk of malignancy of ovarian masses (OMs). Methods: Single-center retrospective evaluation of consecutive patients who underwent transvaginal ultrasound (US) with images storage and surgery for ovarian masses. Radiomics methodology was applied to US images according to the International Biomarker Standardization Initiative guidelines. OMs were divided into three homogeneous groups: solid, cystic and motley. TRACE4
© radiomic platform was used thus obtaining a full-automatic radiomic workflow. Three different classification systems were created and accuracy, sensitivity, specificity, AUC and standard deviation were defined for each group. Results: A total of 241 women were recruited. OMs were divided in the three groups: 95 (39.5%) solid, 66 (27.5%) cystic, 80 (33%) motley. For solid OMs, 269 radiomic features were used for the training-validation-testing of the model with accuracy 80%, sensitivity 78%, specificity 83%, AUC 87%. For cystic OMs, 278 radiomic features were used for the training-validation-testing of the model with accuracy 87%, sensitivity 75%, specificity 90%, AUC 88%. For mixed OMs, 306 radiomic features were used for the training-validation-testing of the model with accuracy 81%, sensitivity 81%, specificity 81%, AUC 89%. Conclusion: Radiomics is a promising tool in improving preoeprative work-up of women diagnosed with OMs. Even in the absence of the subjective impression of expert ultrasound examiner, radiomics allows to easily identify patients with ovarian cancer. Future validation studies on larger series are needed. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
24. Low pressure laparoscopic procedure in morbidly obese patients with endometrial carcinoma using a new subcutaneous abdominal wall-retraction device: a surgical challenge.
- Author
-
Ditto, Antonino, Chiarello, Giulia, Maggiore, Umberto Leone Roberti, Martinelli, Fabio, Bogani, Giorgio, and Raspagliesi, Francesco
- Published
- 2023
- Full Text
- View/download PDF
25. Surveillance alone in stage I malignant ovarian germ cell tumors: a MITO (Multicenter Italian Trials in Ovarian cancer) prospective observational study.
- Author
-
Mangili, Giorgia, Giorda, Giorgio, Ferrandina, Gabriella, Cormio, Gennaro, Cassani, Chiara, Savarese, Antonella, Danese, Saverio, Carnelli, Marco, Vasta, Francesca Maria, Perrone, Anna Myriam, Scarfone, Giovanna, Pignata, Sandro, Legge, Francesco, Raspagliesi, Francesco, Taccagni, Gianluca, Candiani, Massimo, Bogani, Giorgio, Mascilini, Floriana, and Bergamini, Alice
- Published
- 2021
- Full Text
- View/download PDF
26. Transmission of SARS-CoV-2 in Surgical Smoke during Laparoscopy: A Prospective, Proof-of-concept Study.
- Author
-
Bogani, Giorgio, Ditto, Antonino, De Cecco, Loris, Lopez, Salvatore, Guerrisi, Rocco, Piccioni, Federico, Micali, Arianna, Daidone, Maria Grazia, and Raspagliesi, Francesco
- Abstract
Study Objective: There are growing concerns regarding the potential risk of coronavirus disease transmission during surgery and in particular during minimally invasive procedures owing to the aerosolization of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) particles. However, no study has demonstrated this hypothesis. Here, we aimed to investigate the presence of SARS-CoV-2 in surgical smoke.Design: A prospective pilot study.Setting: A tertiary cancer center in northern Italy.Patients: Overall, 17 patients underwent laparoscopic procedures for the management of suspected or documented gynecologic malignancies. The median age was 57 years (range 26-77). The surgical indications included endometrial cancer (n = 11), borderline ovarian tumor (n = 3), early-stage ovarian cancer (n = 1), stage IA cervical cancer after diagnostic conization (n = 1), and an ovarian cyst that turned out to be benign at final histologic examination (n = 1).Interventions: We evaluated all consecutive women scheduled to have laparoscopic procedures for suspected or documented gynecologic cancers. The patients underwent planned laparoscopic surgery. At the end of the laparoscopic procedures (after extubation), we performed reverse transcription-polymerase chain reaction (RT-PCR) tests for the detection of SARS-CoV-2 from both the endotracheal tube and the filter applied on the trocar valve.Measurements and Main Results: In 1 patient, both swab tests (endotracheal tube and trocar valve filter) showed amplification of the N gene on RT-PCR analysis. This case was considered to be a presumptive positive case. In another case, the RT-PCR analysis showed an amplification curve for the N gene only in the swab test performed on the filter. No ORF1ab amplification was detected.Conclusion: Our study suggested the proof of principle that SARS-CoV-2 might be transmitted through surgical smoke and aerosolized native fluid from the abdominal cavity. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
27. Enhanced recovery after surgery (ERAS) in gynecology oncology.
- Author
-
Bogani, Giorgio, Sarpietro, Giuseppe, Ferrandina, Gabriella, Gallotta, Valerio, DI Donato, Violante, Ditto, Antonino, Pinelli, Ciro, Casarin, Jvan, Ghezzi, Fabio, Scambia, Giovanni, and Raspagliesi, Francesco
- Subjects
LENGTH of stay in hospitals ,GYNECOLOGY ,SURGERY ,MEDICAL care costs ,EVIDENCE-based medicine - Abstract
The Enhanced Recovery After Surgery (ERAS) is a pathway designed to achieve early recovery for patients undergoing major surgery. The ERAS pathway included three important components preoperative, intraoperative, postoperative program. Pre-habilitation and re-habilitation are of paramount importance to improve patients' care. The ERAS is based on evidence-based medicine. Accumulating evidence highlighted that adopting ERAS resulted in lower complication rate, and shorter length of hospital stay in comparison to standard protocols of care. The adoption of the ERAS resulted in a significant improvement of patients' outcomes and a reduction of the overall cost of care. In the present review, we summarized current evidence on ERAS, focusing on the steps useful for its adoption into clinical practice. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
28. Pattern of recurrence in endometrial cancer. The murderer always returns to the scene of the crime.
- Author
-
Capozzi, Vito Andrea, Monfardini, Luciano, Maglietta, Giuseppe, Barresi, Giuseppe, De Finis, Alessandra, Rosati, Andrea, Vargiu, Virginia, Cosentino, Francesco, Sozzi, Giulio, Chiantera, Vito, Bogani, Giorgio, Carnelli, Marco, Scambia, Giovanni, Fanfani, Francesco, Ghi, Tullio, and Berretta, Roberto
- Subjects
CANCER relapse ,ENDOMETRIAL cancer ,CRIME scenes ,DISEASE relapse ,LYMPH nodes ,PERITONEUM diseases - Abstract
Endometrial cancer recurrence occurs in about 18 % of patients. This study aims to analyze the pattern recurrence of endometrial cancer and the relationship between the initial site of primary disease and the relapse site in patients undergoing surgical treatment. We retrospectively reviewed all surgically treated patients with endometrial cancer selecting those with recurrence. We defined primary site disease as uterus, lymph nodes, or peritoneum according to pathology analysis of the surgical specimen. The site of recurrence was defined as vaginal cuff, lymph nodes, peritoneum, and parenchymatous organs. Our primary endpoint was to correlate the site of initial disease with the site of recurrence. The study enrolled 1416 patients. The overall recurrence rate was 17,5 % with 248 relapses included in the study. An increase of 9.9, 5.7, and 5.7 times in the odds of relapse on the lymph node, peritoneum, and abdominal parenchymatous sites respectively was observed in case of nodal initial disease (p < 0.001). A not significant difference in odds was observed in terms of vaginal cuff relapse (OR 0.9) between lymph node ad uterine primary disease (p = 0.78). An increasing OR of 8.7 times for nodal recurrences, 46.6 times for peritoneum, and 23.3 times for parenchymatous abdominal recurrences were found in the case of primary peritoneal disease (p < 0.001). Endometrial cancer tends to recur at the initial site of the disease. Intraoperative inspection of the adjacent sites of primary disease and targeted instrumental examination of the initial sites of disease during follow-up are strongly recommended. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
29. Sentinel lymph node biopsy in endometrial cancer: When, how and in which patients.
- Author
-
Leone Roberti Maggiore, Umberto, Spanò Bascio, Ludovica, Alboni, Carlo, Chiarello, Giulia, Savelli, Luca, Bogani, Giorgio, Martinelli, Fabio, Chiappa, Valentina, Ditto, Antonino, and Raspagliesi, Francesco
- Subjects
SENTINEL lymph node biopsy ,ENDOMETRIAL cancer ,LYMPHADENECTOMY ,SENTINEL lymph nodes - Abstract
The role of nodal dissection in patients with endometrial cancer has been intensively studied in several studies. Historically, systematic pelvic and para-aortic lymphadenectomy represented the gold standard surgical treatment to assess potential nodal involvement and consequently define the appropriate stage of the tumor. Over the last years, sentinel node biopsy (SLNB) has been introduced as a more targeted alternative to lymph node dissection for lymph node staging and it has become popular among gynecologic oncologists. However, no level A evidence is still available, and several features of the SLNB technique have been matter of discussion among clinicians and a universally accepted methodology is still not currently available. This narrative review aims to summarize the body of knowledge on SLNB to offer the reader a complete picture about the evolution of this technique over the last decades. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
30. Minimally invasive surgery in cervical cancer.
- Author
-
BOGANI, Giorgio, DI DONATO, Violante, CHIAPPA, Valentina, LOPEZ, Salvatore, MONTI, Marco, MUZII, Ludovico, BENEDETTI PANICI, Pierluigi, DITTO, Antonino, and RASPAGLIESI, Francesco
- Subjects
MINIMALLY invasive procedures ,CERVICAL cancer ,LAPAROSCOPY ,HYSTERECTOMY ,ROBOTICS - Published
- 2021
- Full Text
- View/download PDF
31. Conization and lymph node evaluation as a fertility-sparing treatment for early stage cervical cancer.
- Author
-
Martinelli, Fabio, Ditto, Antonino, Filippi, Francesca, Vinti, Daniele, Bogani, Giorgio, Roberti Maggiore, Umberto Leone, Evangelista, Mariateresa, Signorelli, Mauro, Chiappa, Valentina, Lopez, Salvatore, Somigliana, Edgardo, and Raspagliesi, Francesco
- Abstract
Introduction To evaluate oncological and obstetrical outcomes of early stage cervical cancer patients who underwent conservative management to retain childbearing potential. Methods Data of women (aged <40 years) who underwent fertility sparing treatment for International Federation of Gynecology and Obstetrics (FIGO) stage IA1 with lymphovascular invasion (LVSI) and IB1 cervical cancer were prospectively collected. All patients underwent cervical conization/s and laparoscopic nodal evaluation (pelvic lymphadenectomy/sentinel node mapping). Oncological and obstetrical outcomes were assessed. Results Overall, 39 patients met inclusion criteria; 36 (92.3%) women were nulliparous. There were: 3 (7.7%) IA1-LVSI+; 11 (28.2%) IA2; and 25 (64.1%) IB1 cervical cancers, according to 2018 FIGO stage classification. Histological types were 22 (56.4%) squamous carcinoma and 17 (43.6%) adenocarcinoma. Pelvic lymphadenectomy was performed in 29 (74.4%) patients, while 10 (25.6%) patients had only sentinel node mapping. In 4 (10.3%) patients conservative treatment was discontinued due to nodal involvement and 2 (5.1%) patients requested definitive treatment (hysterectomy) after a negative lymph node evaluation. Among 33 (84.6%) patients who retained their childbearing potential, 17 (51.5%) had a second conization. 2 (6.1%) patients relapsed and underwent definitive treatment. After a median follow-up of 51 months (range 1-184) no deaths were reported. 22 (70.9%) patients attempted to conceive. There were 13 natural pregnancies among 12 (54.5%) women who got pregnant. Live birth rate was 76.9%: 9 (69.2%) term and 1 (7.7%) preterm (at 32 weeks) deliveries. 2 (15.4%) miscarriages (first and second trimester) and 1 (7.7%) termination of pregnancy for medical reasons were recorded. Conclusion Conization plus laparoscopic nodal evaluation may be a safe and feasible conservative option in the setting of fertility-sparing treatment for early-stage cervical cancer patients. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
32. Real-time Fluorescent ICG and 99m-Tc Nanocolloid Tracer Navigation in Bilateral Sentinel Lymph Node Mapping of Vulvar Cancer.
- Author
-
Ditto, Antonino, Ferla, Stefano, Martinelli, Fabio, Bogani, Giorgio, Maggiore, Umberto Leone Roberti, and Raspagliesi, Francesco
- Abstract
The effectiveness of sentinel lymph node (SLN) biopsy has been validated by 2 prospective trials, GROINS VI and GOG 173 [ 1 , 2 ]. According to the European Society of Gynaecological Oncology guideline in patients with unifocal tumors with a diameter of <4 cm, in the absence of suspected inguinal lymph nodes, SLN biopsy is recommended. The use of a radioactive tracer is mandatory [2]. Using indocyanine green (ICG) increases the detection of the vulvar sentinel node from 89.7% to 100% [3]. This video aimed to share our experience about the feasibility, safety, and usefulness of the surgical identification of SLN in vulvar cancer using real-time fluorescent ICG with 99m-technetium (Tc) nanocolloid. A stepwise demonstration of the technique with narrated video footage. Tertiary level hospital "IRCCS Istituto Nazionale dei Tumori," Milano, Italy. A 50-year-old woman was diagnosed as having vulvar cancer on biopsy of 1.5 cm size vulvar lesion under the clitoris area and referred to our operative unit. F-18 fluorodeoxyglucose positron emission tomography computed tomography showed no extravulvar disease. The patient was scheduled for radical vulvectomy and bilateral inguinal SLN biopsy. (Video still 1) In this video, the surgical procedure involved double location of SLN, first with the 99m-Tc detector followed by ICG identification. We used an ICG dilution of 2.5 mg/mL in sterile water and injected 4 mL around the tumor 5 to 10 minutes before visualization. First a handheld gamma probe used to identify the location of the SLNs with 99m-Tc. The fluorescence imaging was performed by the quest imaging system (FLUOPTICS, Middenmeer, The Netherlands) that combines autofluorescence and fluorescence perfusion imaging (Video Still 2). Second, we performed the SLN biopsy using a dark mode procedure to identify the IGC tracer (Video Still 3). The fluorescence imaging enables the detection of these markers through some millimeters of tissue, and ICG has the advantage that is visible through the skin [4]. This video shows a successful combined 99m-Tc and ICG fluorescence image-guided bilateral SLN biopsy in a vulvar cancer patient using a near-infrared optical imaging system (FLUOPTICS). ICG for SLN mapping seems to be safe in women with vulvar cancer with a satisfactory detection rate. This may help in retaining surgical radicality while minimizing operative complications. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
33. Preoperative Conization and Risk of Recurrence in Patients Undergoing Laparoscopic Radical Hysterectomy for Early Stage Cervical Cancer: A Multicenter Study.
- Author
-
Casarin, Jvan, Bogani, Giorgio, Papadia, Andrea, Ditto, Antonino, Pinelli, Ciro, Garzon, Simone, Donadello, Nicoletta, Laganà, Antonio Simone, Cromi, Antonella, Mueller, Michael, Raspagliesi, Francesco, and Ghezzi, Fabio
- Abstract
Study Objective: To investigate the factors associated with poorer oncologic outcomes in patients undergoing laparoscopic radical hysterectomy (LRH) for early stage cervical cancer.Design: Multicenter retrospective study.Setting: Three gynecologic oncology referral centers.Patients: Patients with International Federation of Gynecology and Obstetrics 2009 stage IA (positive lymphovascular space invasion)-IB1 cervical cancer between January 2006 and June 2018.Interventions: LRH (Piver type II-III hysterectomies). Lymph-node dissection was accomplished according to the tumor characteristics.Measurements and Main Results: Surgical and oncologic outcomes were analyzed. Overall, 186 patients met the inclusion criteria, 16 (8.6%) experienced a recurrence, and 9 (4.8%) died of the disease (median follow-up period 37.9 months). Surgery-related complications did not influence disease-free survival. All the recurrences (16/16; 100%) occurred in patients with stage IB1 disease (p = .02), and 15 (93.7%) in cases involving tumors ≥2 cm. No association between positive lymph node and recurrence was detected (p =.82). Patients who had a preoperative diagnosis through conization (93; 50%) had a significantly lower rate of recurrence than those who underwent cervical biopsy (93; 50%): 1/93 (1.1%) vs 15/93 (16.1%); p <.001). The subanalysis of patients with International Federation of Gynecology and Obstetrics stage IB1 cervical cancer showed that patients undergoing preoperative conization (vs cervical biopsy) were less likely to experience a recurrence (odds ratio 0.09; 95% confidence interval 0.01-0.55).Conclusion: We confirmed that LRH was associated with a recurrence rate similar to that reported in the Laparoscopic Approach to Cervical Cancer trial. Tumor size ≥2 cm represents the most important risk factor influencing disease-free survival. However, we found that preoperative conization plays a potentially protective role in patients with an IB1 tumor. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
34. The role of sentinel lymph node mapping in lower genital tract melanoma.
- Author
-
LOPEZ, Salvatore, GUERRISI, Rocco, BRUSADELLI, Claudia, BOGANI, Giorgio, DITTO, Antonino, and RASPAGLIESI, Francesco
- Subjects
GYNECOLOGY periodicals ,SENTINEL lymph nodes ,GENITAL cancer ,MELANOMA - Published
- 2020
- Full Text
- View/download PDF
35. Role of adjuvant therapy in stage IIIC2 endometrial cancer.
- Author
-
Bogani, Giorgio, Cappuccio, Serena, Casarin, Jvan, Narasimhulu, Deepa Maheswari M., Cilby, William A., Glaser, Gretchen E., Weaver, Amy L., McGree, Michaela E., Keeney, Gary L., Weroha, John, Petersen, Ivy A., and Mariani, Andrea
- Abstract
Objective The role of the different types of adjuvant treatments in endometrial cancer with para-aortic node metastases is unclear. The aim of this study was to report oncologic outcomes after adjuvant therapy in patients with stage IIIC2 endometrial cancer. Methods This retrospective single-institution study assessed patients with stage IIIC2 endometrial cancer who underwent primary surgery from January 1984 to December 2014. All patients had hysterectomy (±salpingooophorectomy) plus lymphadenectomy (para-aortic nodes, ±pelvic nodes). We included all patients with stage III endometrial cancer and documented para-aortic lymph node metastases (International Federation of Obstetrics and Gynecologists stage IIIC2). We excluded patients who did not provide consent, who had synchronous cancer, or who underwent neoadjuvant chemotherapy. Follow-up was restricted to the first 5 years post-operatively. Cox proportional hazards models, with age as the time scale, was used to evaluate associations of risk factors with disease-free survival and overall survival. Results Among 105 patients with documented adjuvant therapy, external beam radiotherapy was administered to 25 patients (24%), chemotherapy to 24 (23%), and a combination (chemotherapy and external beam radiotherapy) to 56 (53%) patients. Most patients receiving chemotherapy and external beam radiotherapy (80%) had chemotherapy first. The majority of relapses had a distant component (31/46, 67%) and only one patient had an isolated para-aortic recurrence. Non-endometrioid subtypes had poorer disease-free survival (HR 2.57; 95% CI 1.38 to 4.78) and poorer overall survival (HR 2.00; 95% CI 1.09 to 3.65) compared with endometrioid. Among patients with endometrioid histology (n=60), chemotherapy and external beam radiotherapy improved disease-free survival (HR 0.22; 95% CI 0.07 to 0.71) and overall survival (HR 0.28; 95% CI 0.09 to 0.89) compared with chemotherapy or external beam radiotherapy alone. Combination therapy did not improve prognosis for patients with non-endometrioid histology (n=45). Conclusions In our cohort of patients with stage IIIC2 endometrioid endometrial cancer, those receiving chemotherapy and external beam radiotherapy had improved survival compared with patients receiving chemotherapy or external beam radiotherapy alone. However, the prognosis of patients with non-endometrioid endometrial cancer remained poor, regardless of the adjuvant therapy administered. Distant recurrences were the most common sites of failure. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
36. Patterns of recurrence after laparoscopic versus open abdominal radical hysterectomy in patients with cervical cancer: a propensitymatched analysis.
- Author
-
Bogani, Giorgio, Ghezzi, Fabio, Chiva, Luis, Gisone, Baldo, Pinelli, Ciro, Dell'Acqua, Andrea, Casarin, Jvan, Ditto, Antonino, and Raspagliesi, Francesco
- Abstract
Objective Recent evidence has suggested that laparoscopic radical hysterectomy is associated with an increased risk of recurrence in comparison with open abdominal radical hysterectomy. The aim of our study was to identify patterns of recurrence after laparoscopic and open abdominal radical hysterectomy for cervical cancer. Methods This a retrospective multi-institutional study evaluating patients with recurrent cervical cancer after laparoscopic and open abdominal surgery performed between January 1990 and December 2018. Inclusion criteria were: age ≥18 years old, radical hysterectomy (type B or type C), no recurrent disease, and clinical follow-up >30 days. The primary endpoint was to evaluate patterns of first recurrence following laparoscopic and open abdominal radical hysterectomy. The secondary endpoint was to estimate the effect of the primary surgical approach (laparoscopy and open surgery) in post-recurrence survival outcomes (event-free survival and overall survival). In order to reduce possible confounding factors, we applied a propensity-matching algorithm. Survival outcomes were estimated using the Kaplan-Meier model. results A total of 1058 patients were included in the analysis (823 underwent open abdominal radical hysterectomy and 235 patients underwent laparoscopic radical hysterectomy). The study included 117 (14.2%) and 35 (14.9%) patients who developed recurrent cervical cancer after open or laparoscopic surgery, respectively. Applying a propensity matched comparison (1:2), we reduced the population to 105 patients (35 vs 70 patients with recurrence after laparoscopic and open radical hysterectomy). Median follow-up time was 39.1 (range 4-221) months and 32.3 (range 4-124) months for patients undergoing open and laparoscopic surgery, respectively. Patients undergoing laparoscopic radical hysterectomy had shorter progression-free survival than patients undergoing open abdominal surgery (HR 1.98, 95% CI 1.32 to 2.97; p=0.005). Patients undergoing laparoscopic radical hysterectomy were more likely to develop intrapelvic recurrences (74% vs 34%; p<0.001) and peritoneal carcinomatosis (17% vs 1%; p=0.005) than patients undergoing open surgery. Conclusions Patients undergoing laparoscopic radical hysterectomy are at higher risk of developing intrapelvic recurrences and peritoneal carcinomatosis. Further evidence is needed in order to corroborate our findings. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
37. Sentinel lymph node mapping in endometrial cancer: performance of hysteroscopic injection of tracers.
- Author
-
Martinelli, Fabio, Ditto, Antonino, Bogani, Giorgio, Maggiore, Umberto Leone Roberti, Signorelli, Mauro, Chiappa, Valentina, and Raspagliesi, Francesco
- Subjects
SENTINEL lymph node biopsy ,ENDOMETRIAL cancer ,INDOCYANINE green ,LAPAROSCOPIC surgery ,BODY mass index - Abstract
Objective To report on the performance of hysteroscopic injection of tracers (indocyanine green (ICG) and technetium-99m (Tc-99m)) for sentinel lymph node (SLN) mapping in endometrial cancer. Methods Single-center retrospective evaluation of consecutive patients who underwent SLN mapping following hysteroscopic peritumoral injection of tracer. Detection rate (overall/bilateral/aortic) diagnostic accuracy, and oncologic outcomes were evaluated. Results A total of 221 procedures met the inclusion criteria. Mean patient age was 60 (range 28-84) years and mean body mass index was 26.9 (range 15-47) kg/m2. In 164 cases (70.9%) mapping was performed laparoscopically. The overall detection rate of the technique was 94.1% (208/221 patients). Bilateral pelvic mapping was found in 62.5% of cases with at least one SLN detected and was more frequent using ICG than with Tc-99m (73.8% vs 53.3%; p<0.001). In 47.6% of cases SLNs mapped in both pelvic and aortic nodes, and in five cases (2.4%) only in the aortic area. In eight patients (3.8%) SLNs were found in aberrant (parametrial/presacral) areas. Mean number of detected SLNs was 3.7 (range 1-8). In 51.9% of cases at least one node other than SLNs was removed. Twenty-six patients (12.5%) had nodal involvement: 12 (46.2%) macrometastases, six (23.1%) micrometastases, and eight (30.7%) isolated tumor cells. In 12 cases (46.8%) the aortic area was involved. Overall, 6/221 (2.7%) patients had isolated para-aortic nodes. Three false-negative results were found, all in the Tc-99m group. All had isolated aortic metastases. Overall sensitivity was 88.5% (95% CI 71.7 to 100.0) and overall negative predictive value was 96.5% (95% CI 86.8 to 100.0). There were 10 (4.8%) recurrences: five abdominal/distant, four vaginal, and one nodal (in the aortic area following a unilateral mapping plus side-specific pelvic lymphadenectomy). Most recurrences (9/10 cases) were patients in whom a completion lymphadenectomy was performed. No deaths were reported after a mean follow-up of 47.7 months. Conclusions Hysteroscopic injection of tracers for SLN mapping in endometrial cancer is as accurate as cervical injection with a higher detection rate in the aortic area. ICG improves the bilateral detection rate. Adding lymphadenectomy to SLN mapping does not reduce the risk of relapse. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
38. Lynch syndrome-related non-endometrioid endometrial cancer: analysis of outcomes.
- Author
-
Bogani, Giorgio, Tibiletti, Maria Grazia, Ricci, Maria Teresa, Carnevali, Ileana, Liberale, Viola, Paolini, Biagio, Milione, Massimo, Vitellaro, Marco, Murgia, Ferdinando, Chiappa, Valentina, Ditto, Antonino, Ghezzi, Fabio, and Raspagliesi, Francesco
- Abstract
Objective Women with Lynch syndrome have a risk up to 40-60% of developing endometrial cancer, which is higher than their risk of developing colorectal or ovarian cancer. To date, no data on the outcomes of patients with Lynch syndrome diagnosed with non-endometrioid endometrial cancer are available. The goal of this study was to evaluate the outcome of patients with Lynch syndrome diagnosed with non-endometrioid endometrial cancer. Methods Data from consecutive patients diagnosed with Lynch syndrome and with a histological diagnosis of non-endometrioid endometrial cancer were retrospectively collected in two referral institutes in Italy. A case-control comparison (applying a propensity matching algorithm) was performed in order to compare patients with proven Lynch syndrome and controls. Inclusion criteria were: (a) histologically-proven endometrial cancer; (b) detection of a germline pathogenic variant in one of the MMR genes; (c) adequate follow-up. Only carriers of pathogenic or likely pathogenic variants (ie, class 5 and 4 according to the InSiGHT classification) were included in the study. Survival outcomes were assessed using KaplanMeier and Cox models. results Overall, 137 patients with Lynch syndrome were collected. Mean patient age was 49.2 (10.9) years. Genes involved in the Lynch syndrome included MLH1, MSH2, and MSH6 in 43%, 39%, and 18% of cases, respectively. The study population included 27 patients with non-endometrioid endometrial cancer, who were matched 1:2 with patients with sporadic cancers using a propensity matching algorithm. After a median follow-up of 134 months (range 1-295), 2 (7.4%) of the 27 patients developed recurrent disease (3 and 36 months) and subsequently died of disease (7 and 91 months). Patients diagnosed with Lynch syndrome experienced better disease-free survival (HR 7.86 (95% CI 1.79 to 34.5); p=0.006) and overall survival (HR 5.33 (95% CI 1.18 to 23.9); p=0.029) than controls. Conclusions Non-endometrioid endometrial cancer occurring in patients with Lynch syndrome might be associated with improved oncologic outcomes compared with controls. Genetic/molecular profiling should be investigated in order to better understand the mechanism underlying the prognosis. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
39. Burden of lymphatic disease predicts efficacy of adjuvant radiation and chemotherapy in FIGO 2018 stage IIICp cervical cancer.
- Author
-
Bogani, Giorgio, Vinti, Daniele, Murgia, Ferdinando, Chiappa, Valentina, Roberti Maggiore, Umberto Leone, Martinelli, Fabio, Ditto, Antonino, and Raspagliesi, Francesco
- Abstract
Objective Nodal involvement is one of the most important prognostic factors in cervical cancer patients. We aimed to assess the prognostic role in relation to the burden of nodal disease in stage IIICp cervical cancer. Methods Data on all consecutive patients diagnosed with cervical cancer undergoing primary surgery (radical hysterectomy plus lymphadenectomy) or neoadjuvant chemotherapy followed by radical hysterectomy plus lymphadenectomy, between January 1980 and December 2017, were collected in a dedicated database. Exclusion criteria were: (1) consent withdrawal; (2) synchronous malignancies (within 5 years). Survival outcomes were assessed using Kaplan-Meier and Cox models. Results Overall, 177 (14.1%) of 1257 patients with cervical cancer were diagnosed with positive lymph nodes. After a median follow-up of 58 (range 4-175) months, 66 (37.3%) and 37 (20.9%) patients developed recurrent disease and died of disease, respectively. Via multivariate analysis, positive para-aortic nodes (HR 2.62, 95% C11.12 to 6.11; p=0.025) and the number of positive nodes (HR 1.06, 95% C11.02 to 1.11; p=0.002) correlated with worse disease-free survival. Furthermore, the number of positive nodes (HR 1.06, 95% C11.01 to 1.12; p=0.021) correlated with worse overall survival. Number of positive nodes (1, 2 or >3) strongly correlated with both disease-free survival (p<0.001, log-rank test) and overall survival (p=0.001, log-rank test). Focusing on patients receiving adjuvant radiation and chemotherapy, the number of positive lymph nodes was associated with response to treatment (p<0.001). Median disease-free survival was 100, 42, and 12 months for patients with one, two, or three or more positive lymph node(s), respectively (p<0.001, log-rank test). Conclusions In stage IIICp cervical cancer, adjuvant radiation and chemotherapy provides adequate overall survival in patients diagnosed with only one metastatic node, while survival outcomes are poor in patients with two or more metastatic nodes. This highlights the need for innovative treatments in patients with a high burden of lymphatic disease. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
40. Characteristics and outcomes of surgically staged multiple classifier endometrial cancer.
- Author
-
Bogani, Giorgio, Betella, Ilaria, Multinu, Francesco, Casarin, Jvan, GhezzI, Fabio, Sorbi, Flavia, VizziellI, Giuseppe, Petrillo, Marco, Cianci, Stefano, Berretta, Roberto, PaolinI, Biagio, FanfanI, Francesco, De Vitis, Luigi, Scambia, Giovanni, Mariani, Andrea, Colombo, Nicoletta, and Raspagliesi, Francesco
- Subjects
ENDOMETRIAL cancer ,CANCER patients ,LANDSCAPE changes ,RADIOISOTOPE brachytherapy - Abstract
The growing adoption of molecular and genomic characterization is changing the current landscape of treatment of endometrial cancer patients. Using the surrogate molecular classification, endometrial cancer patients can be classified in four subgroups: POLE mutated (POLE mut), MMRd/MSI-H, p53 abnormal (p53abn), and no specific mutational profile (NSMP). However, some patients can harbor two or more molecular features (defined as multiple classifier). Since the rarity of this occurrence, evidence regarding multiple classifiers is still limited. Here, we described characteristics and outcomes of multiple classifiers. This is a multi-institutional retrospective study. Data of consecutive patients having 2 or more molecular features were collected. Survival was assessed using the Kaplan-Meier and Cox proportional hazard methods. Charts of 72 multiple classifiers were reviewed. Median (range) follow-up was 9.8 (1.2, 37.5) months. Overall, 31 (43%) patients had POLE mut. Patients with POLE mut-MMRd/MSI-H, POLE mut-p53abn, and POLE mut-MMRd/MSI-H-p53abn were 6 (8.3%), 20 (27.8%), and 5 (6.9%), respectively. Among those 31 patients, no recurrence occurred within a median follow-up of 10.5 months (only seven (22.6%) patients had at least 2-year follow-up). The remaining 41 (56.9%) patients were diagnosed with tumors harboring both p53 and MMRd/MSI-H. Among them, four (9.8%) recurrences occurred at a median follow-up time of 8.9 months. Adjuvant therapy (other than vaginal brachytherapy) was administered in 5/31 (16%) and 25/41 (61%) patients with and without POLE mut, respectively (p < 0.001). Multiple classifiers endometrial cancer with POLE mut are characterized by good prognosis even in case of presence of MMRd/MSI-H and/or p53abn. Additional studies with long-term follow-up are needed. • Endometrial cancer patients with more than one molecular classifying feature are classified as "multiple classifiers". • "Multiple classifiers" are rare, accounting for about 5% of all apparent early-stage endometrial cancer. • POLE mutation seems to be associated with good outcomes, even in presence of concomitant p53 abnormality. • Nodal status is the main factor influencing survival in "multiple classifier" endometrial cancers. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
41. Selinexor in patients with advanced and recurrent endometrial cancer.
- Author
-
Bogani, Giorgio, Monk, Bradley J, Coleman, Robert L, Vergote, Ignace, Oakin, Ana, Ray-Coquard, Isabelle, Mariani, Andrea, Scambia, Giovanni, Raspagliesi, Francesco, and Bolognese, Bruno
- Subjects
ENDOMETRIAL cancer ,TUMOR suppressor proteins ,PEMETREXED ,IMMUNE checkpoint inhibitors ,CANCER patients ,NUCLEAR proteins - Abstract
Selinexor is an oral inhibitor of the nuclear export protein called Exportin 1 (XPO1) with demonstrated antitumor activity in hematological and solid tumors. Selinexor, blocking XPO1, induces nuclear localization of tumor suppressor proteins (including p53, p73, BRCA1, and pRB), leading to the selective induction of apoptosis, and inhibition of DNA damage repair proteins. XPO1 overexpression is common in endometrial cancers. Phase I and II trials reported the antitumor activity of selinexor in patients with endometrial carcinoma. The preliminary results of the phase III Selinexor in ENDOmetrial Cancer (SIENDO/ENGOT-EN5/GOG-3055) trial supported the use of selinexor as maintenance therapy in advanced endometrial cancer patients achieving at least partial response after a minimum of 12 weeks of first-line platinum-based chemotherapy. Selinexor maintenance resulted in a (nonsignificant) 30% reduction in the risk of disease progression or death. Looking at the endometrial cancer molecular subgroup characterized by TP53 wild type, the antitumor activity of selinexor seemed more pronounced, resulting in approximately a 60% reduction in the risk of disease progression or death. The SIENDO and the XPORT-EC trials will clarify the benefits and risks of adding selinexor as a first-line chemotherapy maintenance treatment in all-comer and TP53 wild-type endometrial cancers. Preclinical data highlights the potential for selinexor to be synthetically lethal with PARP inhibitors and may also plan a role in overcoming acquired resistance to those therapies. Therefore, new possible combinations with PARP inhibitors and should be evaluated. Furthermore, the combination of selinexor plus immune checkpoint inhibitors deserves further investigation in clinical trials. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
42. Presence of Glandular Cells at the Preoperative Cervical Cytology and Local Recurrence in Endometrial Cancer
- Author
-
Casarin, Jvan, Bogani, Giorgio, Serati, Maurizio, Pinelli, Ciro, Laganà, Antonio Simone, Garzon, Simone, Raspagliesi, Francesco, and Ghezzi, Fabio
- Abstract
We investigated the correlation between glandular cells (GC) detected at preoperative cervical-smear and the histologic findings and oncologic outcomes in patients undergoing surgery for endometrial cancer (EC). We retrospectively analyzed data of all consecutive EC patients who underwent surgery between January 1, 1990 and December 31, 2012 with preoperative cervical smear performed within 3 mo from the EC diagnosis. Basic descriptive, logistic regression and artificial neural network analyses were used. Five-year disease-free survival and overall survival were assessed using Kaplan-Meier and Cox hazard models. The study included 229 (89%) and 29 (11%) patients with normal cytology (control group) and GC (GC group), respectively. A higher proportion of elderly patients with nonendometrioid and FIGO grade 3 EC was observed in the GC group compared with the control group (P<0.05). No differences in 5-yr disease-free survival and overall survival were observed. However, patients in the GC group experienced a higher local recurrence rate (hazard ratio: 7.6; 95% confidence interval: 1.7–34.2; P=0.008). We observed that age, body mass index, cervical stromal invasion, vaginal brachytherapy, and GC influenced the risk for developing local recurrence. However, at the multivariable analysis, only cervical stromal invasion (odds ratio: 1.2; 95% confidence interval: 1.02–1.4; P=0.02) and GC (odds ratio: 1.07; 95% confidence interval: 1.01–1.14; P=0.03) correlated with the increased risk. In addition, the results of an artificial neural network analysis reported that the most critical predictor of local failure was cervical stromal invasion (importance: 0.352) followed by GC (importance: 0.194). These results suggest that cervical stromal invasion and presence of GC at the preoperative cervical smear might predict the occurrence of local recurrence in EC.
- Published
- 2020
- Full Text
- View/download PDF
43. Trends in prevalence in human papillomavirus types and their association with cervical dysplasia: an analysis on 15 138 women over 20 years
- Author
-
Bogani, Giorgio, Chiappa, Valentina, Pinelli, Ciro, Lopez, Salvatore, Signorelli, Mauro, Taverna, Francesca, Lombardo, Claudia, Ditto, Antonino, and Raspagliesi, Francesco
- Abstract
To investigate trends in prevalence of various human papillomavirus types in order to assess the unmet clinical needs for women affected by human papillomavirus-related disease. Data of consecutive 15 138 patients undergoing human papillomavirus DNA testing from 1998 to 2018 were retrospectively identified. Human papillomavirus types were classified at high-risk according to the classification of the International Agency for Research on Cancer. The International Agency for Research on Cancer included seven human papillomavirus types covered by nine-valent vaccine and five not yet covered by any available vaccines. Overall, 4159 (65.3%), 1500 (23.5%) and 714 (11.2%) women had human papillomavirus types covered by nine-valent vaccination, not covered by nine-valent vaccination and co-infections of human papillomavirus types of both groups. At least one high-risk human papillomavirus type(s) was detected in 1241 patients with genital dysplasia: 832 (67.1%), 291 (23.4%) and 118 (9.5%) women had human papillomavirus types covered by nine-valent vaccination, not covered by nine-valent vaccination and co-infections of human papillomavirus types of both groups. Over the twenty-year study period, the number of human papillomavirus types not covered by nine-valent vaccine increased dramatically (from 4 to 16%; P< 0.001, Pfor trend). Similarly, looking at patients with genital dysplasia, high-risk human papillomavirus types not covered by nine-valent vaccine increased from 3 to 13% (P< 0.001, Pfor trend). Our data highlight that human papillomavirus types covered by nine-valent vaccine represent are the main types associated with genital dysplasia. However, over the study period, we observed an increasing prevalence of confections and high-risk human papillomavirus types not covered by the nine-valent vaccine, thus suggesting the need of developing more complete vaccines against human papillomavirus.
- Published
- 2020
- Full Text
- View/download PDF
44. Impact of gene-specific germline pathogenic variants on presentation of endometrial cancer in Lynch syndrome.
- Author
-
Bogani, Giorgio, Maria, Teresa Ricci, Vitellaro, Marco, Ditto, Antonino, Chiappa, Valentina, and Raspagliesi, Francesco
- Subjects
HEREDITARY nonpolyposis colorectal cancer ,ENDOMETRIAL cancer ,CANCER patients ,ONCOLOGY ,CANCER diagnosis - Abstract
Objective: Lynch syndrome is a risk factor for developing endometrial carcinoma. Our aim was to evaluate the impact of gene-specific germline pathogenic variants on clinical features of patients affected by endometrial cancer. Methods: Patients with a diagnosis of endometrial cancer and with a germline pathogenic variant in mismatch repair genes were reviewed. Patients were classified on the basis of classes of risk according to the ESGO-ESGO-ESTRO (European Society of Medical Oncology/European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology) guidelines. One-way analysis of variance (ANOVA) and Kruskal-Wallis test were performed to compare three groups of continuous parametric and non-parametric variables, respectively. χ
2 test was used to analyze proportions. Results: Overall, 68 patients with endometrial cancer and Lynch syndrome were evaluated. Ten (14.7%) patients were excluded because of absence of information about the gene involved in Lynch syndrome, thus leaving 58 (85.3%) patients available for the final analysis. MLH1 , MSH2, and MSH6 pathogenic variants were observed in 19 (32.7%), 33 (56.9%), and six (10.3%) patients, respectively. Mean±SD age at endometrial cancer diagnosis was 51±6.4, 43.5±7.4, and 60.3±8.8 years (p=0.0002). Prevalence of non-endometrioid endometrial cancer was 15.7%, 24.2%, and 0% in the MLH1 , MSH2, and MSH6 groups, respectively (p=0.345). According to the ESMO-ESGO-ESTRO classification, low, intermediate, and high risk endometrial cancer accounted for 47.3%, 10.5%, and 42.1% of the MLH1 group, 57.6%, 3%, and 39.4% of the MSH2 group, and 50%, 50%m and 0% of the MSH6 group (p=0.009). Conclusions: Patients with MLH1 and MSH2 pathogenic variants are at a higher risk of early onset of endometrial cancer than patients with MSH6 pathogenic variants. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
45. Surgical Efforts Might Mitigate Difference in Response to Neoadjuvant Chemotherapy in Stage IIIC–IV Unresectable Ovarian Cancer: A Case-Control Multi-institutional Study.
- Author
-
Raspagliesi, Francesco, Bogani, Giorgio, Matteucci, Laura, Casarin, Jvan, Sabatucci, Ilaria, Tamberi, Stefano, Arcangeli, Valentina, Maltese, Giuseppa, Lepori, Stefano, Comerci, Giuseppe, Stefanetti, Marco, Ditto, Antonino, Martinelli, Fabio, Chiappa, Valentina, and Lorusso, Domenica
- Abstract
Objective: The aim of the study was to evaluate outcomes of patients with unresectable advanced ovarian cancer experiencing complete response (CR) to neoadjuvant chemotherapy. Methods: Data of consecutive patients undergoing neoadjuvant chemotherapy plus interval debulking surgery (IDS) were retrospectively reviewed in 4 Italian centers. Using a propensity-matching algorithm, we compared data of patients achieving CR with neoadjuvant chemotherapy (no macroscopic either microscopic residual disease (RD) at the time of IDS) with patients achieving partial response (PR). This latter group was stratified by the presence of RD (RD = 0 vs RD > 0). Results: Overall, 193 had IDS after neoadjuvant chemotherapy: 25 (13%), 81 (41.9%), and 74 (38.3%) patients had CR, PR with RD of 0, and PR with RD of more than 0, respectively. In addition, 13 (6.7%) patients had no macroscopic disease detected at DS but just microscopic disease at pathological examination. For the study purpose, 25 patients achieving CR were matched (1:2) with 50 patients having PR and RD of 0 and 50 patients having PR and RD of more than 0. As the result of propensity matching, baseline characteristics were similar between groups. Comparing survival outcomes of patients having CR and PR with RD of 0, we observed that type of response to chemotherapy did not influence disease-free (hazard ratio = 1.53 [95% confidence interval = 0.88–2.66], P = 0.127) and overall (hazard ratio = 1.74 [95% confidence interval = 0.76–4.01], P = 0.189) survivals. Patients achieving CR experienced significantly better disease-free survival (P = 0.004) and a trend toward better overall survival (P = 0.06) than patients achieving PR with RD of more than 0 at IDS. Conclusions: Complete cytoreduction might mitigate the difference in response to neoadjuvant chemotherapy. The presence of RD at IDS is associated with worse survival outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
46. The Role of Immunotherapy in Advanced and Recurrent MMR Deficient and Proficient Endometrial Carcinoma
- Author
-
Di Dio, Camilla, Bogani, Giorgio, Di Donato, Violante, Cuccu, Ilaria, Muzii, Ludovico, Musacchio, Lucia, Scambia, Giovanni, and Lorusso, Domenica
- Abstract
The incidence of endometrial cancer has increased approximately 40% in the last decade along with a 60% increase in the number of associated deaths. Although surgery along with possible adjuvant therapy provides good results in patients with early-stage disease, patients with advanced or recurrent disease have limited options and typically undergo chemotherapy with no standard second-line therapy. Immunotherapy with checkpoint inhibitors (ICIs) is a promising option in this setting.This review aims to improve knowledge on the role of ICIs in advanced/recurrent endometrial cancer in different contexts based on molecular and genomic profiling. The DNA mismatch repair (MMR) system is a highly conserved mechanism that acts to restore DNA integrity after mismatching mistakes during replication, recombination, or iatrogenic damage. Somatic or germline mutations or epigenetic silencing can all result in possible inactivation of MMR genes, resulting in an MMR-deficient (dMMR) genotype. Short tandem repeats, called microsatellites, are repetitive DNA sequences that facilitate slippage or replication errors that are generally repaired by MMR; however, in a dMMR context, these can result in repeat mutations called microsatellite instability (MSI). The presence of MSI characterizes a hypermutable state of cell, and MSI tumors have elevated expression of the checkpoint programmed death 1 ligand (PD-L1). Microsatellite instability/dMMR testing may have potential prognostic value as a predictor of response to immunotherapy.Endometrial cancer is the solid tumor characterized by the highest prevalence of MSI−/dMMR, which is present in 30% and 13% to 30% of primary and recurrent endometrial cancer, respectively. Recently, results from the KEYNOTE-158 trial reporting on the efficacy and safety of pembrolizumab (programmed death 1 [PD-1] ICI) in patients with MSI-H/dMMR endometrial cancer who progressed after a prior line of chemotherapy showed an objective response rate of 48%, median progression-free survival of 13.1 months, and a low rate of high-grade toxicity. Results from the GARNET study reporting on the use of dostarlimab (PD-1 ICI) in dMMR advanced endometrial tumors showed that 80% of patients experienced progression-free survival of 18 months and an objective response rate of 44.7%. Several trials have examined the use of ICIs for patients with advanced endometrial carcinoma in MMR-proficient tumors; however, they seem to show a lesser effect in this setting. Results are more promising in MMR-proficient patients when ICIs are combined with other agents such as tyrosine kinase inhibitors; however, the toxicity profile is significantly worse, and efficacy remains significantly higher in the dMMR group. The KEYNOTE-775 study, a phase III randomized controlled trial, found that in patients with advanced or recurrent endometrial cancer pembrolizumab plus lenvatinib (tyrosine kinase inhibitor) increased progression-free survival (6.6 vs 3.8 months) and overall survival (17.4 vs 12 months) compared with conventional chemotherapy; however, treatment discontinuation and dose reduction occurred in 33% and 70% of patients, respectively.This review describes and evaluates the use of new lines of treatment including immunotherapy agents for advanced and recurrent endometrial cancer. Many trials are still ongoing, with several testing ICIs alone or in combination with other agents to improve safety profiles and efficacy.
- Published
- 2023
- Full Text
- View/download PDF
47. Ovarian preservation in locally advanced cervical cancer undergoing neoadjuvant chemotherapy and radical surgery.
- Author
-
SIGNORELLI, Mauro, BOGANI, Giorgio, CHIAPPA, Valentina, DITTO, Antonino, SCAFFA, Cono, MARTINELLI, Fabio, LORUSSO, Domenica, and RASPAGLIESI, Francesco
- Published
- 2018
- Full Text
- View/download PDF
48. Factors Predictive of 90-Day Morbidity, Readmission, and Costs in Patients Undergoing Pelvic Exenteration.
- Author
-
Bogani, Giorgio, Signorelli, Mauro, Ditto, Antonino, Martinelli, Fabio, Casarin, Jvan, Mosca, Lavinia, Leone Roberti Maggiore, Umberto, Chiappa, Valentina, Lorusso, Domenica, and Raspagliesi, Francesco
- Abstract
Objective: Pelvic exenteration for recurrent gynecological malignancies is characterized by a high rate of severe complications. Factors predictive of morbidity, readmission, and cost were analyzed. Methods: Data of consecutive patients undergoing pelvic exenteration between January 2007 and December 2016 were prospectively evaluated. Results: Fifty-eight patients were included in the analysis. Anterior, posterior, and total exenterations were executed in 39 (67%), 9 (16%), and 10 (17%) patients, respectively. Ten (15.5%) severe complications occurred: 8 (20.5%), 0 (0%), and 1 (10%) after anterior, posterior, and total exenterations, respectively. Radiotherapy dosage, time between radiotherapy and surgery, and previous administration of chemotherapy did not influence 90-day complications and readmission. At multivariable analysis, albumin levels less than 3.5 g/dL (odds ratio, 16.2 [95% confidence interval, 2.85–92.8];
P = 0.002) and history of deep vein thrombosis (odds ratio, 9.6 [95% confidence interval, 0.93–98.2];P = 0.057) were associated with 90-day morbidity. Low albumin levels independently correlated with readmission (P = 0.011). The occurrence of 90-day postoperative complications and readmission increased costs of a median of +12,500 and +6000 euros, respectively (P < 0.05). Conclusions: Preoperative patient selection is a key point for the reduction of postoperative complications after pelvic exenteration. Further prospective studies are warranted to improve patient selection. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
49. Nerve-Sparing Approach Improves Outcomes of Patients Undergoing Minimally Invasive Radical Hysterectomy: A Systematic Review and Meta-Analysis.
- Author
-
Bogani, Giorgio, Rossetti, Diego Oreste, Ditto, Antonino, Signorelli, Mauro, Martinelli, Fabio, Mosca, Lavinia, Scaffa, Cono, Leone Roberti Maggiore, Umberto, Chiappa, Valentina, Sabatucci, Ilaria, Lorusso, Domenica, and Raspagliesi, Francesco
- Abstract
Few studies have investigated the efficacy and safety of the nerve-sparing approach via minimally invasive surgery for the treatment of cervical cancer. We aimed to review the current evidence comparing nerve-sparing minimally invasive radical hysterectomy (NS-MRH) with conventional minimally invasive radical hysterectomy (MRH). This systematic review was registered in the International Prospective Register of Systematic Reviews (CRD#57655). Overall, 675 patients were included: 350 (51.9%) and 325 (48.1%) patients undergoing MRH and NS-MRH, respectively. MRH was associated with a shorter operative time in comparison with NS-MRH (mean difference = 32.57 minutes; 95% CI, 22.87-42.48). The estimated blood loss (mean difference = 97.14 mL, 20.01-214.29) and transfusion rate (odds ratio [OR] = 0.67; 95% confidence interval [CI], 0.15-3.01) did not differ statistically between the 2 groups. The risk of developing intraoperative (OR = 0.43; 95% CI, 0.08-2.23) and severe postoperative (OR = 0.63; 95% CI, 0.17-2.39) complications was similar between NS-MRH and MRH. Patients undergoing NS-MRH experienced lower voiding (OR = 0.39; 95% CI, 0.19-0.81) dysfunction rates than patients undergoing MRH. Moreover, a trend toward lower sexual (OR = 0.25; 95% CI, 0.06-1.07) and rectal (OR = 0.12; 95% CI, 0.01-1.02) issues was observed for patients having NS-MRH compared with patients undergoing MRH. Survival outcomes are not influenced by the type of surgical approach (recurrence [OR = 1.27; 95% CI, 0.49-3.28] and death [OR = 1.01; 95% CI, 0.36-2.83]) rates. The pooled data suggested that NS-MRH is equivalent to MRH for the treatment of cervical cancer and may be superior in reducing pelvic floor dysfunction rates. However, because of the low level of evidence of the included studies, further randomized trials are warranted. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
50. Invasive Paget Disease of the Vulva.
- Author
-
Borghi, Chiara, Bogani, Giorgio, Ditto, Antonino, Martinelli, Fabio, Signorelli, Mauro, Chiappa, Valentina, Scaffa, Cono, Perotto, Stefania, Roberti Maggiore, Umberto Leone, Recalcati, Dario, Lorusso, Domenica, and Raspagliesi, Francesco
- Abstract
Objective: Extramammary Paget disease of the vulva (EPDV) is a rare occurrence with an indolent and relapsing course. Progression to invasion occurs in 4% to 19% of cases. The aim of this study is to report clinical-pathological features and outcomes of patients treated for invasive EPDV. Methods: Data of consecutive patients treated between 2000 and 2017 for invasive EPDV were reviewed. Results: Among 79 patients with EPDV, 10 (12.7%) presented a microinvasive or invasive form at first diagnosis or during follow-up. All of them underwent upfront radical surgery; 7 (70%) received subsequent radiotherapy, chemotherapy, or both. The mortality rate was 40%. The recurrence rate after treatment for invasive forms was 60%, with a mean time to first recurrence of 20 (range, 5-36) months. Conclusions: Our study confirms that invasive EPDV remains a rare gynecological neoplasm with a poor prognosis. Multicentre trials or well-organized prospective data collection could improve the knowledge about the management of invasive EPDV. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.