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5 results on '"Bima, Paolo"'

1. External validation of the myocardial-ischaemic-injury-index machine learning algorithm for the early diagnosis of myocardial infarction: a multicentre cohort study

Author

Lopez-Ayala, Pedro, Boeddinghaus, Jasper, Nestelberger, Thomas, Koechlin, Luca, Zimmermann, Tobias, Bima, Paolo, Glaeser, Jonas, Spagnuolo, Carlos C, Champetier, Arnaud, Miro, Oscar, Martin-Sanchez, Francisco Javier, Keller, Dagmar I, Christ, Michael, Wildi, Karin, Breidthardt, Tobias, Strebel, Ivo, Mueller, Christian, Reichlin, Tobias, Kaeslin, Marina, Potlukova, Eliska, Kawecki, Damian, Geigy, Nicolas, Rentsch, Katharina, Shrestha, Samyut, Guzman-Tacla, Caroline A., Herraiz-Recuenco, Lourdes, Morawiec, Beata, Munzk, Piotr, Freese, Michael, Martinez-Nadal, Gemma, Fuenzalida, Carolina, Calderon, Sofia, Rodriguez Adrada, Esther, Ganovská, Eva, Parenica, Jiri, von Eckardstein, Arnold, Campodarve, Isabel, and Gea, Joachim

Abstract

The myocardial-ischaemic-injury-index (MI3) is a novel machine learning algorithm for the early diagnosis of type 1 non-ST-segment elevation myocardial infarction (NSTEMI). The performance of MI3, both when using early serial blood draws (eg, at 1 h or 2 h) and in direct comparison with guideline-recommended algorithms, remains unknown. Our aim was to externally validate MI3and compare its performance with that of the European Society of Cardiology (ESC) 0/1h-algorithm.

Published
2024
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2. Extending the no objective testing rules to patients triaged by the European Society of Cardiology 0/1-hour algorithms

Author

Ratmann, Paul David, Boeddinghaus, Jasper, Nestelberger, Thomas, Lopez-Ayala, Pedro, Huré, Gabrielle, Gehrke, Juliane, Koechlin, Luca, Wildi, Karin, Mueller, Philip, Bima, Paolo, Wussler, Desiree, Gisler, Nicolas, Miro, Oscar, Martín-Sánchez, F Javier, Christ, Michael, Gualandro, Danielle M, Twerenbold, Raphael, Gimenez, Maria Rubini, Keller, Dagmar I, Buser, Andreas, and Mueller, Christian

Abstract

Graphical Abstract

Published
2022
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3. Norepinephrine may improve survival of septic shock patients in a low-resource setting: a proof-of-concept study on feasibility and efficacy outside the Intensive Care Unit

Author

Bima, Paolo, Orlotti, Carmen, Smart, Okot Godfrey, Morello, Fulvio, Trunfio, Mattia, Brazzi, Luca, and Montrucchio, Giorgia

Abstract

ABSTRACTSeptic shock treatment in sub-Saharan African hospitals is challenging due to limited availability of ICUs, central venous catheters, vasopressors, and trained staff. We designed this proof-of-concept study to determine efficacy, safety, and feasibility of norepinephrine (NE) use in a non-intensive setting in a low-resource country, consisting in a peripheral infusion via a mechanical drop counter. Septic shock patients accessing a rural hospital in Uganda were included: the 2020 group (N = 12) was prospectively enrolled (Jan–Mar 2020) when NE was available; the 2019 group (N = 11) was retrospectively enrolled (Oct–Dec 2019). Enrollment was continuous to reduce selection bias. Basic clinical endpoints (noninvasive blood pressure, tissue perfusion, diuresis) defined shock control and the prognostic endpoint was survival at hospital discharge. Shock control at 6 and 12 hours was higher in the 2020 group (p = 0.012 for both). Survival at hospital discharge was 75% and 27.3%, respectively (p = 0.039). NE infusion was associated with a Hazard Ratio of 0.23 (p = 0.041) in a multivariate Cox model. No NE-induced adverse effects were detected. These preliminary results suggest that implementing NE infusion in a low-resource setting without ICU could be a safe and effective strategy in managing septic shock and that this approach could lead to a lower mortality rate.

Published
2022
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4. Lung Ultrasonography for the Diagnosis of SARS-CoV-2 Pneumonia in the Emergency Department

Author

Pivetta, Emanuele, Goffi, Alberto, Tizzani, Maria, Locatelli, Stefania M., Porrino, Giulio, Losano, Isabel, Leone, Dario, Calzolari, Gilberto, Vesan, Matteo, Steri, Fabio, Ardito, Arianna, Capuano, Marialessia, Gelardi, Maria, Silvestri, Giulia, Dutto, Stefania, Avolio, Maria, Cavallo, Rossana, Bartalucci, Alice, Paglieri, Cristina, Morello, Fulvio, Richiardi, Lorenzo, Maule, Milena M., Lupia, Enrico, Baldassa, Federico, Baron, Paolo, Bianchi, Giordano, V, Busso, Conterno, Andrea, Del Rizzo, Paola, Fascio Pecetto, Paolo, Giachino, Francesca, Iannaccone, Andrea, Ferrera, Patrizia, Riccardini, Franco, Sacchi, Claudia, Sozzi, Michela, Totaro, Silvia, Visconti, Pasqualina, Risi, Francesca, Basile, Francesca, Baricocchi, Denise, Beux, Alessia, Beux, Valentina, Bima, Paolo, Cara, Irene, Chichizola, Liliana, Dellavalle, Francesca, Grosso, Federico, Labarile, Giulia, Oddi, Matteo, Ottino, Marco, Pia, Ilaria, Scategni, Virginia, and Surra, Astrid

Abstract

Accurate diagnostic testing to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical. Although highly specific, SARS-CoV-2 reverse transcriptase–polymerase chain reaction (RT-PCR) has been shown in clinical practice to be affected by a noninsignificant proportion of false-negative results. This study seeks to explore whether the integration of lung ultrasonography with clinical evaluation is associated with increased sensitivity for the diagnosis of coronavirus disease 2019 pneumonia, and therefore may facilitate the identification of false-negative SARS-CoV-2 RT-PCR results.

Published
2021
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5. Diagnostic Accuracy of the Aortic Dissection Detection Risk Score Plus D-Dimer for Acute Aortic Syndromes

Author

Nazerian, Peiman, Mueller, Christian, Soeiro, Alexandre de Matos, Leidel, Bernd A., Salvadeo, Sibilla Anna Teresa, Giachino, Francesca, Vanni, Simone, Grimm, Karin, Oliveira, Múcio Tavares, Pivetta, Emanuele, Lupia, Enrico, Grifoni, Stefano, Morello, Fulvio, Capretti, Elisa, Castelli, Matteo, Gualtieri, Simona, Trausi, Federica, Battista, Stefania, Bima, Paolo, Carbone, Federica, Tizzani, Maria, Veglio, Maria G., Badertscher, Patrick, Boeddinghaus, Jasper, Nestelberger, Thomas, and Twerenbold, Raphael

Abstract

Supplemental Digital Content is available in the text.

Published
2018
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