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Bergamasco, JGA, Gomes da Silva, D, Bittencourt, DF, Martins de Oliveira, R, Júnior, JCB, Caruso, FC, Godoi, D, Borghi-Silva, A, and Libardi, CA. Low-load resistance training performed to muscle failure or near muscle failure does not promote additional gains on muscle strength, hypertrophy, and functional performance of older adults. J Strength Cond Res36(5): 1209–1215, 2022—The aim of the present study was to compare the effects of low-load resistance training (RT) protocols performed to failure (FAI), to voluntary interruption (VOL), and with a fixed low repetitions (FIX) on muscle strength, hypertrophy, and functional performance in older adults. Forty-one subjects (60–77 years) were randomized into one of the RT protocols (FAI, VOL, or FIX) and completed 12 weeks of RT at 40% of 1 repetition maximum (1RM), twice a week. The assessments included 1RM test, muscle cross-sectional area (CSA), rate of torque development (RTD), and functional performance (chair stand [CS], habitual gait speed [HGS], maximal gait speed [MGS], and timed up-and-go [TUG]). All protocols significantly increased 1RM values from Pre (FAI: 318.3 ± 116.3 kg; VOL: 342.9 ± 93.7 kg; FIX: 328.0 ± 107.2 kg) to Post (FAI: 393.0 ± 143.1 kg, 23.5%; VOL: 423.0 ± 114.5 kg, 23.3%; FIX: 397.8 ± 94.6 kg, 21.3%; p< 0.0001 for all groups). Regarding CS, all protocols showed significant improvements from Pre (FAI: 11.5 ± 2.4 seconds; VOL: 12.1 ± 2.5 seconds; FIX: 11.3 ± 1.1 seconds) to Post (FAI: 10.5 ± 1.1 seconds, −8.5%, p= 0.001; VOL: 10.3 ± 1.5 seconds, −15.1%, p= 0.001; FIX: 11.0 ± 1.1, −3.2%, p= 0.001). Habitual gait speed values increased significantly from Pre (FAI: 1.3 ± 0.2 m·s−1; VOL: 1.3 ± 0.1 m·s−1; FIX: 1.3 ± 0.1 m·s−1) to Post (FAI: 1.4 ± 0.2 m·s−1, 2.5%, p= 0.03; VOL: 1.4 ± 0.2 m·s−1, 5.2%, p= 0.036; FIX: 1.4 ± 0.1 m·s−1, 5.7%, p= 0.03). No significant differences between protocols were found (p> 0.05). In addition, there were no significant changes in CSA, RTD, MGS, and TUG for any protocols (p> 0.05). In conclusion, low-load RT performed without muscle failure promotes significant improvements in muscle strength and some parameters of functional performance in older adults.